ellipticine and etoposide

ellipticine has been researched along with etoposide in 32 studies

Research

Studies (32)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.25)18.7374
1990's9 (28.13)18.2507
2000's8 (25.00)29.6817
2010's11 (34.38)24.3611
2020's2 (6.25)2.80

Authors

AuthorsStudies
Hwang, HJ; Kim, JS; Kim, YS; Lee, EJ; Lee, SK; Park, HJ; Ryu, CK; Suh, ME; Yi, YJ1
Choo, HY; Kim, JS; Lee, HJ; Lee, IK; Lee, SK; Park, HJ; Rhee, HK; Ryu, CK; Suh, ME1
Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J1
Estévez-Braun, A; Jiménez-Alonso, S; Machín, F; Orellana, HC; Pérez-Sacau, E; Ravelo, AG1
Austin, CP; Fidock, DA; Hayton, K; Huang, R; Inglese, J; Jiang, H; Johnson, RL; Su, XZ; Wellems, TE; Wichterman, J; Yuan, J1
Brimble, MA; Lorenzo-Castrillejo, I; Machín, F; Sperry, J1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Akkarawongsapat, R; Jariyawat, S; Kasisit, J; Kongkum, N; Napaswad, C; Piyachaturawat, P; Pohmakotr, M; Reutrakul, V; Suksen, K; Tuchinda, P1
Mandi, P; Nantasenamat, C; Pingaew, R; Prachayasittikul, S; Prachayasittikul, V; Ruchirawat, S1
Mandi, P; Nantasenamat, C; Pingaew, R; Prachayasittikul, S; Prachayasittikul, V; Ruchirawat, S; Saekee, A1
Cao, HT; Chau, MV; Cho, WJ; Jin, Y; Khadka, DB; Kwon, Y; Le, TN; Nguyen, HT; Shin, S; Tran, GH; Van, HT; Zhao, C1
Nantasenamat, C; Pingaew, R; Prachayasittikul, S; Prachayasittikul, V; Ruchirawat, S; Worachartcheewan, A1
Bist, G; Kadayat, TM; Kwon, Y; Lee, ES; Lee, HJ; Park, S; Shrestha, A; Thapa Magar, TB1
Liu, Y; Xu, Z; Zhao, SJ1
Hwang, SY; Jeon, KH; Kadayat, TM; Katila, P; Kim, D; Kunwar, S; Kwon, Y; Lee, ES; Park, S1
Guo, H; Sun, S; Wang, G1
Sumner, AT1
Hsu, MT; Wong, ML1
Shin, CG; Snapka, RM1
Evans, HH; Horng, MF; Mencl, J; Ricanati, M1
Charcosset, JY; Garbay-Jaureguiberry, C; Jacquemin-Sablon, A; Rigaudy, P; Roques, BP1
Filatov, MV; Varfolomeeva, EY1
Best-Belpomme, M; Nahon, E; Saucier, JM1
Frei, H; Würgler, FE1
Falaschi, A; Ochem, A; Phan, TN; Tuteja, N; Tuteja, R1
Cline, SD; Macdonald, TL; Osheroff, N1
Phan, TN; Tuteja, N1
Deslandes, E; Gauduchon, P; Godard, T; Poul, JM; Sichel, F1
Hait, WN; Nayak, MS; Yang, JM1
Pham, XH; Tran, NQ; Tuteja, N; Tuteja, R1
Maszewski, J; Polit, JT; Winnicki, K; Żabka, A1
Arlt, VM; Feser, K; Indra, R; Mrizova, I; Phillips, DH; Sozeri, O; Stiborova, M; Willis, AJ; Wohak, LE1

Reviews

2 review(s) available for ellipticine and etoposide

ArticleYear
1,2,3-Triazole-containing hybrids as potential anticancer agents: Current developments, action mechanisms and structure-activity relationships.
    European journal of medicinal chemistry, 2019, Dec-01, Volume: 183

    Topics: Antineoplastic Agents; Humans; Molecular Structure; Neoplasms; Structure-Activity Relationship; Triazoles

2019
Current status of carbazole hybrids as anticancer agents.
    European journal of medicinal chemistry, 2022, Feb-05, Volume: 229

    Topics: Antineoplastic Agents; Carbazoles; Cell Cycle Checkpoints; Cell Proliferation; Coumarins; Humans; Indoles; Pyrazoles; Pyrimidines; Structure-Activity Relationship

2022

Other Studies

30 other study(ies) available for ellipticine and etoposide

ArticleYear
6-Arylamino-7-chloro-quinazoline-5,8-diones as novel cytotoxic and DNA topoisomerase inhibitory agents.
    Bioorganic & medicinal chemistry letters, 2004, Jul-05, Volume: 14, Issue:13

    Topics: Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Inhibitory Concentration 50; Quinazolines; Structure-Activity Relationship; Topoisomerase Inhibitors

2004
Synthesis of 6-chloroisoquinoline-5,8-diones and pyrido[3,4-b]phenazine-5,12-diones and evaluation of their cytotoxicity and DNA topoisomerase II inhibitory activity.
    Bioorganic & medicinal chemistry, 2007, Jan-01, Volume: 15, Issue:1

    Topics: Caco-2 Cells; Cell Line, Tumor; Cell Proliferation; DNA; Drug Screening Assays, Antitumor; Drug Stability; Enzyme Inhibitors; Humans; Isoquinolines; Molecular Structure; Permeability; Phenazines; Stereoisomerism; Structure-Activity Relationship; Topoisomerase II Inhibitors

2007
Chemical genetics reveals a complex functional ground state of neural stem cells.
    Nature chemical biology, 2007, Volume: 3, Issue:5

    Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells

2007
Design and synthesis of a novel series of pyranonaphthoquinones as topoisomerase II catalytic inhibitors.
    Journal of medicinal chemistry, 2008, Nov-13, Volume: 51, Issue:21

    Topics: Aldehydes; Antigens, Neoplasm; Catalysis; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Superhelical; Drug Design; Enzyme Inhibitors; Humans; Models, Molecular; Molecular Structure; Naphthoquinones; Protein Binding; Pyrans; Structure-Activity Relationship; Topoisomerase II Inhibitors

2008
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum.
    Nature chemical biology, 2009, Volume: 5, Issue:10

    Topics: Animals; Antimalarials; ATP Binding Cassette Transporter, Subfamily B, Member 1; Chromosome Mapping; Crosses, Genetic; Dihydroergotamine; Drug Design; Drug Resistance; Humans; Inhibitory Concentration 50; Mutation; Plasmodium falciparum; Quantitative Trait Loci; Transfection

2009
Pyranonaphthoquinone derivatives of eleutherin, ventiloquinone L, thysanone and nanaomycin A possessing a diverse topoisomerase II inhibition and cytotoxicity spectrum.
    Bioorganic & medicinal chemistry, 2009, Oct-15, Volume: 17, Issue:20

    Topics: Antineoplastic Agents; Enzyme Inhibitors; Naphthoquinones; Saccharomyces cerevisiae; Topoisomerase II Inhibitors

2009
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Cytotoxic, antitopoisomerase IIα, and anti-HIV-1 activities of triterpenoids isolated from leaves and twigs of Gardenia carinata.
    Journal of natural products, 2013, Apr-26, Volume: 76, Issue:4

    Topics: Anti-HIV Agents; Antineoplastic Agents, Phytogenic; Drug Screening Assays, Antitumor; Gardenia; HIV-1; Microbial Sensitivity Tests; Molecular Structure; Plant Leaves; Plant Stems; Thailand; Topoisomerase II Inhibitors; Triterpenes

2013
Design, synthesis and molecular docking studies of novel N-benzenesulfonyl-1,2,3,4-tetrahydroisoquinoline-based triazoles with potential anticancer activity.
    European journal of medicinal chemistry, 2014, Jun-23, Volume: 81

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Isoquinolines; Molecular Docking Simulation; Molecular Structure; Structure-Activity Relationship; Triazoles; Vero Cells

2014
Synthesis, biological evaluation and molecular docking of novel chalcone-coumarin hybrids as anticancer and antimalarial agents.
    European journal of medicinal chemistry, 2014, Oct-06, Volume: 85

    Topics: Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Chalcone; Chemistry Techniques, Synthetic; Coumarins; Cysteine Endopeptidases; Humans; Molecular Docking Simulation; Plasmodium falciparum; Protein Conformation; Triazoles; Tubulin

2014
Substituted 2-arylquinazolinones: Design, synthesis, and evaluation of cytotoxicity and inhibition of topoisomerases.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; HeLa Cells; Humans; Molecular Structure; Quinazolinones; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2015
Novel 1,4-naphthoquinone-based sulfonamides: Synthesis, QSAR, anticancer and antimalarial studies.
    European journal of medicinal chemistry, 2015, Oct-20, Volume: 103

    Topics: Antimalarials; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Hep G2 Cells; Humans; Molecular Structure; Naphthoquinones; Parasitic Sensitivity Tests; Plasmodium falciparum; Quantitative Structure-Activity Relationship; Sulfonamides

2015
Rational design, synthesis, and evaluation of novel 2,4-Chloro- and Hydroxy-Substituted diphenyl Benzofuro[3,2-b]Pyridines: Non-intercalative catalytic topoisomerase I and II dual inhibitor.
    European journal of medicinal chemistry, 2017, Feb-15, Volume: 127

    Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Biocatalysis; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; DNA; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Drug Design; Humans; Pyridines; Structure-Activity Relationship; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

2017
Discovery of a 2,4-diphenyl-5,6-dihydrobenzo(h)quinolin-8-amine derivative as a novel DNA intercalating topoisomerase IIα poison.
    European journal of medicinal chemistry, 2021, Dec-15, Volume: 226

    Topics: Amines; Antineoplastic Agents; Cell Proliferation; DNA Topoisomerases, Type II; Dose-Response Relationship, Drug; Drug Discovery; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Structure-Activity Relationship; Topoisomerase II Inhibitors; Tumor Cells, Cultured

2021
Inhibitors of topoisomerases do not block the passage of human lymphocyte chromosomes through mitosis.
    Journal of cell science, 1992, Volume: 103 ( Pt 1)

    Topics: Amsacrine; Camptothecin; Chromosome Aberrations; Chromosomes, Human; Daunorubicin; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; Ellipticines; Ethidium; Etoposide; Humans; In Vitro Techniques; Lymphocytes; Mitosis; Mitoxantrone; Nalidixic Acid; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1992
Involvement of topoisomerases in replication, transcription, and packaging of the linear adenovirus genome.
    Journal of virology, 1990, Volume: 64, Issue:2

    Topics: Adenoviruses, Human; Alkaloids; Blotting, Southern; Camptothecin; Cell Nucleus; Deoxyribonucleoproteins; DNA Replication; DNA Topoisomerases, Type I; DNA Topoisomerases, Type II; DNA, Viral; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Ellipticines; Etoposide; HeLa Cells; Humans; Microscopy, Electron; Templates, Genetic; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Transcription, Genetic

1990
Patterns of strongly protein-associated simian virus 40 DNA replication intermediates resulting from exposures to specific topoisomerase poisons.
    Biochemistry, 1990, Dec-11, Volume: 29, Issue:49

    Topics: Animals; Camptothecin; Chlorocebus aethiops; Deoxyribonucleoproteins; DNA Replication; DNA, Viral; Ellipticines; Etoposide; Proflavine; Simian virus 40; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors

1990
Relationship between topoisomerase II and radiosensitivity in mouse L5178Y lymphoma strains.
    Mutation research, 1989, Volume: 217, Issue:1

    Topics: Amsacrine; Animals; Cells, Cultured; DNA Repair; DNA Topoisomerases, Type II; Ellipticines; Etoposide; Leukemia L5178; Leukemia, Experimental; Mice; Mutation; Radiation Tolerance; Species Specificity; Thymidine Kinase

1989
Attempts to target antitumor drugs toward opioid receptor-rich mouse tumor cells with enkephalin-ellipticinium conjugates.
    Cancer research, 1989, Apr-01, Volume: 49, Issue:7

    Topics: Alkaloids; Animals; DNA; DNA Topoisomerases, Type II; Drug Carriers; Ellipticines; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Etoposide; Fluorescence; Mice; Rats; Receptors, Opioid

1989
Active dissociation of Hoechst 33342 from DNA in living mammalian cells.
    Mutation research, 1995, Volume: 327, Issue:1-2

    Topics: Benzimidazoles; DNA; Ellipticines; Etoposide; Fluorescence; HeLa Cells; Humans; Novobiocin; Topoisomerase II Inhibitors

1995
Analysis of the DNA topoisomerase-II-mediated cleavage of the long terminal repeat of Drosophila 1731 retrotransposon.
    European journal of biochemistry, 1993, Nov-15, Volume: 218, Issue:1

    Topics: Amsacrine; Animals; Base Sequence; DNA; DNA Topoisomerases, Type II; DNA Transposable Elements; Drosophila; Ellipticines; Etoposide; Molecular Sequence Data; Repetitive Sequences, Nucleic Acid

1993
Induction of somatic mutation and recombination by four inhibitors of eukaryotic topoisomerases assayed in the wing spot test of Drosophila melanogaster.
    Mutagenesis, 1996, Volume: 11, Issue:4

    Topics: Animals; Camptothecin; Drosophila melanogaster; Ellipticines; Enzyme Inhibitors; Etoposide; Female; Male; Mutagenicity Tests; Mutation; Recombination, Genetic; Teniposide; Topoisomerase I Inhibitors

1996
Inhibition of DNA unwinding and ATPase activities of human DNA helicase II by chemotherapeutic agents.
    Biochemical and biophysical research communications, 1997, Jul-30, Volume: 236, Issue:3

    Topics: Adenosine Triphosphatases; Amsacrine; Antineoplastic Agents; Aphidicolin; Camptothecin; Dactinomycin; Daunorubicin; DNA; DNA Helicases; Ellipticines; Enzyme Inhibitors; Ethidium; Etoposide; Genistein; Humans; Isoflavones; Nogalamycin; Novobiocin; Topoisomerase I Inhibitors

1997
Azatoxin is a mechanistic hybrid of the topoisomerase II-targeted anticancer drugs etoposide and ellipticine.
    Biochemistry, 1997, Oct-21, Volume: 36, Issue:42

    Topics: Amino Acid Substitution; Animals; Antineoplastic Agents; Cattle; DNA; Drosophila; Drug Design; Ellipticines; Enzyme Inhibitors; Etoposide; Humans; Indoles; Intercalating Agents; Kinetics; Molecular Structure; Recombinant Proteins; Saccharomyces cerevisiae; Thymus Gland; Topoisomerase II Inhibitors

1997
Inhibition of pea chloroplast DNA helicase unwinding and ATPase activities by DNA-interacting ligands.
    Biochemical and biophysical research communications, 1998, Mar-27, Volume: 244, Issue:3

    Topics: Adenosine Triphosphatases; Adenosine Triphosphate; Amsacrine; Camptothecin; Chloroplasts; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Ethidium; Etoposide; Genistein; Hydrolysis; Intercalating Agents; Ligands; Nogalamycin; Novobiocin; Pisum sativum

1998
Detection of topoisomerase inhibitor-induced DNA strand breaks and apoptosis by the alkaline comet assay.
    Mutation research, 2002, Sep-26, Volume: 520, Issue:1-2

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Apoptosis; Camptothecin; Cell Survival; CHO Cells; Comet Assay; Cricetinae; DNA Damage; DNA Fragmentation; Ellipticines; Enzyme Inhibitors; Etoposide; Formazans; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Topotecan

2002
Effect of a single nucleotide polymorphism in the murine double minute 2 promoter (SNP309) on the sensitivity to topoisomerase II-targeting drugs.
    Cancer research, 2007, Jun-15, Volume: 67, Issue:12

    Topics: Amsacrine; Animals; Antineoplastic Agents; Cell Line, Tumor; DNA Topoisomerases, Type II; Drug Resistance, Neoplasm; Ellipticines; Etoposide; Humans; Immunoblotting; Mice; Microscopy, Confocal; Mitoxantrone; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Proto-Oncogene Proteins c-mdm2; Reverse Transcriptase Polymerase Chain Reaction

2007
Inhibition of unwinding and ATPase activities of pea MCM6 DNA helicase by actinomycin and nogalamycin.
    Plant signaling & behavior, 2011, Volume: 6, Issue:3

    Topics: Adenosine Triphosphatases; Camptothecin; Cisplatin; Dactinomycin; Daunorubicin; DNA Helicases; Ellipticines; Enzyme Inhibitors; Etoposide; Intercalating Agents; Mitoxantrone; Nogalamycin; Novobiocin; Pisum sativum; Plant Proteins

2011
The effects of anti-DNA topoisomerase II drugs, etoposide and ellipticine, are modified in root meristem cells of Allium cepa by MG132, an inhibitor of 26S proteasomes.
    Plant physiology and biochemistry : PPB, 2015, Volume: 96

    Topics: Allium; Cysteine Proteinase Inhibitors; Ellipticines; Etoposide; Histones; Leupeptins; Meristem; Phosphorylation; Plant Roots; Proteasome Endopeptidase Complex; Topoisomerase II Inhibitors

2015
The impact of chemotherapeutic drugs on the CYP1A1-catalysed metabolism of the environmental carcinogen benzo[a]pyrene: Effects in human colorectal HCT116 TP53(+/+), TP53(+/-) and TP53(-/-) cells.
    Toxicology, 2018, 04-01, Volume: 398-399

    Topics: Activation, Metabolic; Benzo(a)pyrene; Carcinogens; Cell Survival; Cisplatin; Colorectal Neoplasms; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP3A; DNA Adducts; DNA Damage; Ellipticines; Enzyme Induction; Etoposide; Genes, p53; HCT116 Cells; Humans; Tumor Suppressor Protein p53

2018