eliprodil has been researched along with piperidines in 70 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (5.71) | 18.7374 |
1990's | 54 (77.14) | 18.2507 |
2000's | 10 (14.29) | 29.6817 |
2010's | 1 (1.43) | 24.3611 |
2020's | 1 (1.43) | 2.80 |
Authors | Studies |
---|---|
Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA | 1 |
Harms, J; Woodward, JJ | 1 |
Coupez, M; Eich, F; Garreau, M; Giroux, C; L'Heritier, C; Morselli, PL | 1 |
Gessa, GL; Hmaidan, Y; Rossetti, ZL | 1 |
Nowicki, JP; Poignet, H; Scatton, B | 1 |
Duval, D; Gauffeny, C; Nowicki, JP; Roome, N; Scatton, B | 1 |
Heikkila, RE; Riordan, DE; Sonsalla, PK | 1 |
Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B | 1 |
Bremer, ME; Contreras, PC; Gray, NM | 1 |
Benavides, J; Gotti, B; MacKenzie, ET; Scatton, B | 1 |
Carter, C; Rivy, JP; Scatton, B | 1 |
Cler, J; Contreras, PC; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL | 1 |
Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B | 1 |
Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B | 1 |
Carter, C; Fage, D; Nankai, M | 1 |
Hashimoto, K; London, ED | 1 |
Diana, M; Gessa, G; Rossetti, ZL | 1 |
Brohier, S; Danjou, P; Hergueta, T; Molinier, P; Patat, A; Puech, A; Warot, D; Zieleniuk, I | 1 |
Benavides, J; Cudennec, A; Duverger, D; Nowicki, JP; Scatton, B | 1 |
Balster, RL; Nicholson, KL; Sanger, DJ | 1 |
Scatton, B | 1 |
Avenet, P; Biton, B; Carreau, A; Depoortere, H; Granger, P; Scatton, B | 1 |
Monnet, FP | 1 |
Benavides, J; Scatton, B; Serrano, A; Toulmond, S | 1 |
Layer, RT; Olds, T; Popik, P; Skolnick, P | 1 |
Garrigou-Gadenne, D; Morselli, PL; Thenot, JP | 1 |
Holzbach, R; Modell, S; Naber, D | 1 |
Avenet, P; Biton, B; Depoortere, H; Granger, P; Scatton, B | 1 |
Brooks, S; Kaur, S; Starr, BS; Starr, MS | 1 |
Hicks, C; O'Neill, MJ; Ward, M | 1 |
Haglid, KG; Moller, CJ; Sharp, FR; Wang, S; Yang, Q | 1 |
Bath, CP; Bleakman, D; Farrell, LN; Gilmore, J; Hicks, CA; O'Neill, MJ; Ward, MA | 1 |
Kotlinska, J; Liljequist, S | 2 |
Carter, C; Fage, D; Klarica, M; Nankai, M | 1 |
Ascalone, V; Malavasi, B; Ripamonti, M; Rouchouse, A | 1 |
Cordon, JJ; Coughenour, LL | 1 |
Avenet, P; Besnard, F; Depoortere, H; Graham, D; Léonardon, J; Scatton, B | 1 |
Avenet, P; Biton, B; Godet, D; Granger, P | 1 |
Pahk, AJ; Williams, K | 1 |
Leibrock, J; Prücher, H; Rautenberg, W | 1 |
Depoortere, H; Françon, D; Santamaria, R; Scatton, B | 1 |
Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M | 1 |
Benavides, J; Lekieffre, D; Nowicki, JP; Scatton, B | 1 |
Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX | 1 |
Kapin, MA; Opitz, T; Reyes, A; Reyes, M; Stanton, PK | 1 |
Wiley, JL | 1 |
Barnéoud, P; Hogg, S; Moser, PC; Perron, C; Sanger, DJ | 1 |
Décorps, M; Hommel, M; Ibarrola, D; Jaillard, A; Massarelli, R; Seegers, H | 1 |
Bespalov, A; Dravolina, O; Sukhotina, I | 1 |
Brotchie, JM; Hill, MP; Nash, JE | 1 |
Bolland, K; Sooriyarachchi, MR; Whitehead, J | 1 |
Demerens, C; Lubetzki, C; Stankoff, B; Zalc, B | 1 |
Ebert, U; Löscher, W; Wlaź, P | 1 |
DeSantis, L; Kapin, MA; Nawy, S; Pang, IH; Wexler, EM | 1 |
Chandler, ML; DeSantis, LM; Doshi, R; Kapin, MA; Scatton, B | 1 |
Balster, RL; Beardsley, PM; Bespalov, AY | 1 |
Sharif, NA; Xu, SX | 1 |
Balster, RL; Beardsley, PM; Bespalov, AY; Dravolina, OA; Zvartau, EE | 1 |
Bespalov, AY; Dravolina, OA; Zvartau, EE | 1 |
Höfner, G; Pabel, J; Wanner, KT | 1 |
Lanis, A; Schmidt, WJ | 1 |
Cebere, A; Cebers, G; Liljequist, S; Wägner, A | 1 |
Dominguez, HD; Garcia, GG; Riley, EP; Thomas, JD | 1 |
Biliczki, P; Dézsi, L; Horváth, C; Iost, N; Lengyel, C; Németh, M; Papp, JG; Tálosi, L; Varró, A; Virág, L | 1 |
Shuaib, A; Wang, CX | 1 |
Bolland, K; Sooriyarachchi, MR; Whitehead, A; Whitehead, J | 1 |
Missel, PJ; Stevens, LE | 1 |
Chen, Y; Hu, CP; Jian, X; Li, P; Liu, LY; Lu, JX; Pan, GP; Ping, S; Wan, GR; Wang, SX; Zhao, FR; Zhu, ML | 1 |
Bechthold, E; Daniliuc, C; Ritter, N; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B | 1 |
3 review(s) available for eliprodil and piperidines
Article | Year |
---|---|
Excitatory amino acid receptor antagonists: a novel treatment for ischemic cerebrovascular diseases.
Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Pipecolic Acids; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate | 1994 |
[Involvement of sigma receptors in schizophrenic syndromes. Pathophysiological approach].
Topics: Antipsychotic Agents; Carbazoles; Hippocampus; Humans; Piperidines; Psychotropic Drugs; Pyrimidines; Receptors, sigma; Remoxipride; Schizophrenia; Thalamus | 1993 |
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury.
Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamate; Glutamic Acid; Humans; Neuroprotective Agents; Phenylcarbamates; Piperidines; Propylene Glycols; Protein Conformation; Rats; Receptors, N-Methyl-D-Aspartate | 2005 |
3 trial(s) available for eliprodil and piperidines
Article | Year |
---|---|
Lack of amnestic, psychotomimetic or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist.
Topics: Adult; Affect; Arousal; Attention; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Mental Recall; Midazolam; Neuropsychological Tests; Piperidines; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate; Retention, Psychology | 1994 |
Efficacy and safety of an opiate sigma-receptor antagonist (SL 82.0715) in schizophrenic patients with negative symptoms: an open dose-range study.
Topics: Adult; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Receptors, sigma; Schizophrenia; Schizophrenic Psychology | 1996 |
Stereoselective determination of unchanged and glucuroconjugated eliprodil, a new anti-ischaemic drug, in human plasma and urine by precolumn derivatization and column-switching high-performance liquid chromatography with fluorescence detection.
Topics: Calibration; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Glucuronates; Glucuronidase; Humans; Indicators and Reagents; Piperidines; Quality Control; Reference Standards; Reproducibility of Results; Specimen Handling; Spectrometry, Fluorescence; Stereoisomerism | 1996 |
64 other study(ies) available for eliprodil and piperidines
Article | Year |
---|---|
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture.
Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter | 1992 |
The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation.
Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cocaine; Dopamine; Male; N-Methylaspartate; Norepinephrine; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate | 1992 |
Pilot studies on the effect of SL 82.0715 in psychotic syndromes.
Topics: Antipsychotic Agents; Humans; Piperidines; Psychotic Disorders; Receptors, Opioid; Receptors, sigma | 1992 |
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats.
Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Ethanol; Male; Morphine; Naloxone; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome | 1992 |
Lack of neuroprotective effect of some sigma ligands in a model of focal cerebral ischemia in the mouse.
Topics: Animals; Brain Ischemia; Cerebral Cortex; Dose-Response Relationship, Drug; Guanidines; Isoquinolines; Ligands; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma | 1992 |
SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons.
Topics: Animals; Biogenic Polyamines; Cerebral Cortex; Cytoplasm; Dizocilpine Maleate; In Vitro Techniques; Male; Microscopy, Electron; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vacuoles | 1992 |
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice.
Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase | 1991 |
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex.
Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord | 1990 |
Ifenprodil and SL 82.0715 potently inhibit binding of [3H](+)-3-PPP to sigma binding sites in rat brain.
Topics: Animals; Binding, Competitive; Brain; Dopamine Agents; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Tritium | 1990 |
The pharmacotherapy of focal cortical ischaemia in the mouse.
Topics: Animals; Calcium Channel Blockers; Cell Survival; Cyclandelate; Ischemic Attack, Transient; Male; Mice; Molecular Structure; N-Methylaspartate; Piperidines; Platelet Activating Factor; Receptors, GABA-A; Receptors, Opioid; Receptors, sigma; Vincamine | 1990 |
Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor.
Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Glutamates; Male; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine | 1989 |
Ifenprodil and SL 82.0715 antagonize N-methyl-D-aspartate (NMDA)-coupled glycine receptor responses in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Cyclic GMP; Glycine; Injections; Male; Mice; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Time Factors | 1989 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction | 1988 |
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties.
Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord | 1988 |
NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA-evoked striatal acetylcholine but not spermidine release.
Topics: Acetylcholine; Animals; Corpus Striatum; Desipramine; Dextromethorphan; Indoleacetic Acids; N-Methylaspartate; Phenols; Phenylacetates; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spider Venoms | 1995 |
Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of sigma receptors.
Topics: Animals; Binding, Competitive; Drug Interactions; In Vitro Techniques; Kinetics; Ligands; Male; Pentazocine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereoisomerism | 1995 |
Rewarding and aversive effects of ethanol: interplay of GABA, glutamate and dopamine.
Topics: Alcoholism; Animals; Aversive Therapy; Dizocilpine Maleate; Dopamine; Electrophysiology; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reward; Synaptic Transmission | 1993 |
Effect of eliprodil, an NMDA receptor antagonist acting at the polyamine modulatory site, on local cerebral glucose use in the rat in the rat brain.
Topics: Animals; Biogenic Polyamines; Brain; Glucose; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1994 |
Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats.
Topics: Animals; Appetitive Behavior; Brain; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Macaca mulatta; Male; Motivation; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration | 1994 |
The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons.
Topics: Animals; Calcium Channels; Cells, Cultured; Cerebral Cortex; Electrophysiology; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 1994 |
Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window.
Topics: Animals; Autoradiography; Benzodiazepines; Binding Sites; Brain; Brain Injuries; Dizocilpine Maleate; Drug Administration Schedule; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors | 1993 |
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715).
Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Polyamines; Brain Chemistry; Down-Regulation; Excitatory Amino Acid Antagonists; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Receptors, Glycine | 1995 |
Influence of the rate of intravenous administration of eliprodil (SL 82.0715), a new anti-ischaemic agent, on its distribution in rat plasma and tissues.
Topics: Animals; Brain; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Myocardium; Piperidines; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1995 |
Block of P-type Ca2+ channels by the NMDA receptor antagonist eliprodil in acutely dissociated rat Purkinje cells.
Topics: Animals; Binding Sites; Cadmium; Calcium Channel Blockers; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Fluspirilene; In Vitro Techniques; omega-Agatoxin IVA; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solutions; Spider Venoms | 1995 |
Motor actions of eliprodil in the normal and monoamine-depleted mouse: a role in the treatment of Parkinson's disease?
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Biogenic Monoamines; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Efferent Pathways; Excitatory Amino Acid Antagonists; Levodopa; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Neurons; Parkinson Disease; Phenethylamines; Piperidines; Receptors, Dopamine D1; Reserpine; Sympatholytics | 1996 |
Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia.
Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Gerbillinae; Indazoles; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Quinoxalines | 1996 |
Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-injured neurones.
Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Heat-Shock Proteins; Molecular Weight; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1996 |
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia.
Topics: Animals; Body Temperature; Brain Ischemia; Calcium Channels; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate | 1996 |
Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizures.
Topics: Acoustic Stimulation; Administration, Oral; Animals; Anticonvulsants; Central Nervous System Depressants; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Male; Motor Activity; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome | 1996 |
Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds.
Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dantrolene; Excitatory Amino Acid Antagonists; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin | 1996 |
Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes.
Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Female; Haloperidol; Illicit Drugs; Kinetics; Oocytes; Phencyclidine; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Trifluperidol; Xenopus | 1997 |
Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes.
Topics: Animals; Binding Sites; Electric Conductivity; Excitatory Amino Acid Antagonists; Female; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus | 1997 |
R- and L-type Ca2+ channels are insensitive to eliprodil in rat cultured cerebellar granule neurons.
Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Drug Interactions; Neurons; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Piperidines; Rats; Spider Venoms | 1997 |
Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes.
Topics: Animals; Excitatory Amino Acid Antagonists; Haloperidol; Hydrogen-Ion Concentration; Neuroprotective Agents; Nylidrin; Oocytes; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus laevis | 1997 |
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor.
Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 1997 |
The NMDA/glycine receptor antagonist, L-701,324, produces discriminative stimuli similar to those of ethanol.
Topics: Administration, Oral; Animals; Behavior, Animal; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Male; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1997 |
Neuroprotective effects of eliprodil in a rat hippocampal slice hypoxia model.
Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Neuroprotective Agents; Piperidines; Rats; Synapses | 1997 |
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells.
Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E | 1997 |
Neuroprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model.
Topics: Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; Disease Models, Animal; Fibrinolytic Agents; Hemostasis; Male; Neurologic Examination; Neuroprotective Agents; Partial Thromboplastin Time; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Plasminogen Activator | 1997 |
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid.
Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides | 1997 |
Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage.
Topics: Animals; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia; In Vitro Techniques; Ischemia; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley | 1998 |
Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition.
Topics: Acoustic Stimulation; Animals; Biguanides; Biogenic Polyamines; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Inhibition, Psychological; Male; Nitric Oxide Synthase; Nitroarginine; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle | 1998 |
Neuroprotective effect of eliprodil: attenuation of a conditioned freezing deficit induced by traumatic injury of the right parietal cortex in the rat.
Topics: Analysis of Variance; Animals; Brain Injuries; Cognition Disorders; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Fear; Male; Neuroprotective Agents; Parietal Lobe; Piperidines; Rats; Rats, Sprague-Dawley; Time and Motion Studies; Time Factors | 1998 |
The effect of eliprodil on the evolution of a focal cerebral ischaemia in vivo.
Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Magnetic Resonance Imaging; Male; Multivariate Analysis; Piperidines; Radiography; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 1998 |
Place conditioning of mice with the NMDA receptor antagonists, eliprodil and dizocilpine.
Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Housing, Animal; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Piperidines; Receptors, N-Methyl-D-Aspartate; Social Environment; Stress, Physiological | 1998 |
Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat.
Topics: Animals; Antiparkinson Agents; Binding, Competitive; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reserpine | 1999 |
Sample size review in a head injury trial with ordered categorical responses.
Topics: Craniocerebral Trauma; Glasgow Coma Scale; Humans; Models, Statistical; Piperidines; Prognosis; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Sample Size; Treatment Outcome | 1998 |
Eliprodil stimulates CNS myelination: new prospects for multiple sclerosis?
Topics: Animals; Axons; Central Nervous System; Coculture Techniques; Drug Evaluation, Preclinical; Forecasting; Mice; Multiple Sclerosis; Myelin Sheath; Neurons; Neuroprotective Agents; Oligodendroglia; Piperidines; Receptors, sigma; Stimulation, Chemical; Triiodothyronine | 1999 |
Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats.
Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kindling, Neurologic; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate | 1999 |
Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells.
Topics: Animals; Cell Death; Cells, Cultured; Drug Combinations; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells | 1999 |
Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia.
Topics: Animals; Choline O-Acetyltransferase; Electroretinography; Injections; Injections, Intraperitoneal; Ischemia; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Piperidines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body | 1999 |
N-Methyl-D-aspartate receptor antagonists and the development of tolerance to the discriminative stimulus effects of morphine in rats.
Topics: Animals; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate | 1999 |
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection?
Topics: Aged; Aged, 80 and over; Biguanides; Binding Sites; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina | 1999 |
Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats.
Topics: Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; Piperazines; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate | 2000 |
Decrement in operant performance produced by NMDA receptor antagonists in the rat: tolerance and cross-tolerance.
Topics: Animals; Conditioning, Operant; Depression, Chemical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Memantine; Piperidines; Psychomotor Performance; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Water | 2000 |
Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists.
Topics: Excitatory Amino Acid Antagonists; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism | 2000 |
NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent.
Topics: Animals; Conditioning, Classical; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Male; Phenols; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate | 2001 |
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity.
Topics: Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine | 2002 |
Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits.
Topics: Animals; Animals, Newborn; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Learning Disabilities; Male; Neuroprotective Agents; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley | 2004 |
Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk.
Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Barium Compounds; Chlorides; Dogs; Electrocardiography; Electrophysiology; Female; Heart; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neuroprotective Agents; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Rabbits | 2004 |
The sequential analysis of repeated binary responses: a score test for the case of three time points.
Topics: Clinical Trials as Topic; Craniocerebral Trauma; Data Interpretation, Statistical; Excitatory Amino Acid Antagonists; Glasgow Outcome Scale; Humans; Models, Biological; Models, Statistical; Piperidines | 2006 |
Adaptation of USP types II and IV controlled release assays for sparingly soluble compounds by direct eluent HPLC analysis.
Topics: Algorithms; Buffers; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Excitatory Amino Acid Antagonists; Piperidines; Polytetrafluoroethylene; Solubility | 2006 |
Vitamin B6 prevents isocarbophos-induced vascular dementia in rats through N-methyl-D-aspartate receptor signaling.
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebrovascular Circulation; Dementia, Vascular; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Hippocampus; Hypertension; Malathion; Male; Maze Learning; Memory; Piperidines; Posterior Cerebral Artery; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Ultrasonography, Doppler; Vitamin B 6; Vitamin B Complex | 2018 |
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil.
Topics: Ligands; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tropanes | 2022 |