Page last updated: 2024-08-24

eliprodil and piperidines

eliprodil has been researched along with piperidines in 70 studies

Research

Studies (70)

Timeframe	Studies, this research(%)	All Research%
pre-1990	4 (5.71)	18.7374
1990's	54 (77.14)	18.2507
2000's	10 (14.29)	29.6817
2010's	1 (1.43)	24.3611
2020's	1 (1.43)	2.80

Authors

Authors	Studies
Butler, TW; Chenard, BL; Prochniak, MA; Shalaby, IA	1
Harms, J; Woodward, JJ	1
Coupez, M; Eich, F; Garreau, M; Giroux, C; L'Heritier, C; Morselli, PL	1
Gessa, GL; Hmaidan, Y; Rossetti, ZL	1
Nowicki, JP; Poignet, H; Scatton, B	1
Duval, D; Gauffeny, C; Nowicki, JP; Roome, N; Scatton, B	1
Heikkila, RE; Riordan, DE; Sonsalla, PK	1
Carter, CJ; Lloyd, KG; Scatton, B; Zivkovic, B	1
Bremer, ME; Contreras, PC; Gray, NM	1
Benavides, J; Gotti, B; MacKenzie, ET; Scatton, B	1
Carter, C; Rivy, JP; Scatton, B	1
Cler, J; Contreras, PC; Emmett, MR; Iyengar, S; Mick, S; Rao, TS; Wood, PL	1
Bertin, J; Carter, C; Dupont, R; Duverger, D; Frost, J; Gaudilliere, B; Gotti, B; MacKenzie, ET; Rousseau, J; Scatton, B	1
Arbilla, S; Benavides, J; Carter, C; Legendre, P; Lloyd, KG; MacKenzie, ET; Noel, F; Thuret, F; Vincent, JD; Zivkovic, B	1
Carter, C; Fage, D; Nankai, M	1
Hashimoto, K; London, ED	1
Diana, M; Gessa, G; Rossetti, ZL	1
Brohier, S; Danjou, P; Hergueta, T; Molinier, P; Patat, A; Puech, A; Warot, D; Zieleniuk, I	1
Benavides, J; Cudennec, A; Duverger, D; Nowicki, JP; Scatton, B	1
Balster, RL; Nicholson, KL; Sanger, DJ	1
Scatton, B	1
Avenet, P; Biton, B; Carreau, A; Depoortere, H; Granger, P; Scatton, B	1
Monnet, FP	1
Benavides, J; Scatton, B; Serrano, A; Toulmond, S	1
Layer, RT; Olds, T; Popik, P; Skolnick, P	1
Garrigou-Gadenne, D; Morselli, PL; Thenot, JP	1
Holzbach, R; Modell, S; Naber, D	1
Avenet, P; Biton, B; Depoortere, H; Granger, P; Scatton, B	1
Brooks, S; Kaur, S; Starr, BS; Starr, MS	1
Hicks, C; O'Neill, MJ; Ward, M	1
Haglid, KG; Moller, CJ; Sharp, FR; Wang, S; Yang, Q	1
Bath, CP; Bleakman, D; Farrell, LN; Gilmore, J; Hicks, CA; O'Neill, MJ; Ward, MA	1
Kotlinska, J; Liljequist, S	2
Carter, C; Fage, D; Klarica, M; Nankai, M	1
Ascalone, V; Malavasi, B; Ripamonti, M; Rouchouse, A	1
Cordon, JJ; Coughenour, LL	1
Avenet, P; Besnard, F; Depoortere, H; Graham, D; Léonardon, J; Scatton, B	1
Avenet, P; Biton, B; Godet, D; Granger, P	1
Pahk, AJ; Williams, K	1
Leibrock, J; Prücher, H; Rautenberg, W	1
Depoortere, H; Françon, D; Santamaria, R; Scatton, B	1
Ciani, E; Contestabile, A; Dall'Olio, R; Gandolfi, O; Sparapani, M	1
Benavides, J; Lekieffre, D; Nowicki, JP; Scatton, B	1
Camarasa, J; Camins, A; Escubedo, E; Gabriel, C; Pallàs, M; Sureda, FX	1
Kapin, MA; Opitz, T; Reyes, A; Reyes, M; Stanton, PK	1
Wiley, JL	1
Barnéoud, P; Hogg, S; Moser, PC; Perron, C; Sanger, DJ	1
Décorps, M; Hommel, M; Ibarrola, D; Jaillard, A; Massarelli, R; Seegers, H	1
Bespalov, A; Dravolina, O; Sukhotina, I	1
Brotchie, JM; Hill, MP; Nash, JE	1
Bolland, K; Sooriyarachchi, MR; Whitehead, J	1
Demerens, C; Lubetzki, C; Stankoff, B; Zalc, B	1
Ebert, U; Löscher, W; Wlaź, P	1
DeSantis, L; Kapin, MA; Nawy, S; Pang, IH; Wexler, EM	1
Chandler, ML; DeSantis, LM; Doshi, R; Kapin, MA; Scatton, B	1
Balster, RL; Beardsley, PM; Bespalov, AY	1
Sharif, NA; Xu, SX	1
Balster, RL; Beardsley, PM; Bespalov, AY; Dravolina, OA; Zvartau, EE	1
Bespalov, AY; Dravolina, OA; Zvartau, EE	1
Höfner, G; Pabel, J; Wanner, KT	1
Lanis, A; Schmidt, WJ	1
Cebere, A; Cebers, G; Liljequist, S; Wägner, A	1
Dominguez, HD; Garcia, GG; Riley, EP; Thomas, JD	1
Biliczki, P; Dézsi, L; Horváth, C; Iost, N; Lengyel, C; Németh, M; Papp, JG; Tálosi, L; Varró, A; Virág, L	1
Shuaib, A; Wang, CX	1
Bolland, K; Sooriyarachchi, MR; Whitehead, A; Whitehead, J	1
Missel, PJ; Stevens, LE	1
Chen, Y; Hu, CP; Jian, X; Li, P; Liu, LY; Lu, JX; Pan, GP; Ping, S; Wan, GR; Wang, SX; Zhao, FR; Zhu, ML	1
Bechthold, E; Daniliuc, C; Ritter, N; Schepmann, D; Schreiber, JA; Seebohm, G; Wünsch, B	1

Reviews

3 review(s) available for eliprodil and piperidines

Article	Year
Excitatory amino acid receptor antagonists: a novel treatment for ischemic cerebrovascular diseases. Life sciences, 1994, Volume: 55, Issue:25-26 Topics: Animals; Brain Ischemia; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Humans; Pipecolic Acids; Piperidines; Receptors, AMPA; Receptors, Kainic Acid; Receptors, N-Methyl-D-Aspartate	1994
[Involvement of sigma receptors in schizophrenic syndromes. Pathophysiological approach]. Presse medicale (Paris, France : 1983), 1993, Feb-13, Volume: 22, Issue:5 Topics: Antipsychotic Agents; Carbazoles; Hippocampus; Humans; Piperidines; Psychotropic Drugs; Pyrimidines; Receptors, sigma; Remoxipride; Schizophrenia; Thalamus	1993
NMDA/NR2B selective antagonists in the treatment of ischemic brain injury. Current drug targets. CNS and neurological disorders, 2005, Volume: 4, Issue:2 Topics: Animals; Brain; Brain Ischemia; Conotoxins; Drug Design; Excitatory Amino Acid Antagonists; Felbamate; Glutamic Acid; Humans; Neuroprotective Agents; Phenylcarbamates; Piperidines; Propylene Glycols; Protein Conformation; Rats; Receptors, N-Methyl-D-Aspartate	2005

Trials

3 trial(s) available for eliprodil and piperidines

Article	Year
Lack of amnestic, psychotomimetic or impairing effect on psychomotor performance of eliprodil, a new NMDA antagonist. International clinical psychopharmacology, 1994, Volume: 9, Issue:3 Topics: Adult; Affect; Arousal; Attention; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Mental Recall; Midazolam; Neuropsychological Tests; Piperidines; Psychomotor Performance; Receptors, N-Methyl-D-Aspartate; Retention, Psychology	1994
Efficacy and safety of an opiate sigma-receptor antagonist (SL 82.0715) in schizophrenic patients with negative symptoms: an open dose-range study. Pharmacopsychiatry, 1996, Volume: 29, Issue:2 Topics: Adult; Excitatory Amino Acid Antagonists; Female; Humans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Receptors, sigma; Schizophrenia; Schizophrenic Psychology	1996
Stereoselective determination of unchanged and glucuroconjugated eliprodil, a new anti-ischaemic drug, in human plasma and urine by precolumn derivatization and column-switching high-performance liquid chromatography with fluorescence detection. Journal of chromatography. A, 1996, Apr-05, Volume: 729, Issue:1-2 Topics: Calibration; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Glucuronates; Glucuronidase; Humans; Indicators and Reagents; Piperidines; Quality Control; Reference Standards; Reproducibility of Results; Specimen Handling; Spectrometry, Fluorescence; Stereoisomerism	1996

Other Studies

64 other study(ies) available for eliprodil and piperidines

Article	Year
Neuroprotective effects of the N-methyl-D-aspartate receptor antagonists ifenprodil and SL-82,0715 on hippocampal cells in culture. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 260, Issue:2 Topics: Animals; Cells, Cultured; Culture Media; Dizocilpine Maleate; Drug Antagonism; Glutamates; Glutamic Acid; Hippocampus; L-Lactate Dehydrogenase; N-Methylaspartate; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter	1992
The putative polyamine antagonists ifenprodil and SL 82.0715 enhance dopamine efflux from rat striatal slices independent of NMDA receptor activation. European journal of pharmacology, 1992, Jan-21, Volume: 210, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Brain; Cocaine; Dopamine; Male; N-Methylaspartate; Norepinephrine; Piperidines; Polyamines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate	1992
Pilot studies on the effect of SL 82.0715 in psychotic syndromes. Clinical neuropharmacology, 1992, Volume: 15 Suppl 1 Pt A Topics: Antipsychotic Agents; Humans; Piperidines; Psychotic Disorders; Receptors, Opioid; Receptors, sigma	1992
Marked inhibition of mesolimbic dopamine release: a common feature of ethanol, morphine, cocaine and amphetamine abstinence in rats. European journal of pharmacology, 1992, Oct-20, Volume: 221, Issue:2-3 Topics: Amphetamine; Animals; Cocaine; Corpus Striatum; Dizocilpine Maleate; Dopamine; Ethanol; Male; Morphine; Naloxone; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Substance Withdrawal Syndrome	1992
Lack of neuroprotective effect of some sigma ligands in a model of focal cerebral ischemia in the mouse. Brain research, 1992, Nov-20, Volume: 596, Issue:1-2 Topics: Animals; Brain Ischemia; Cerebral Cortex; Dose-Response Relationship, Drug; Guanidines; Isoquinolines; Ligands; Male; Mice; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma	1992
SL 82.0715, an NMDA antagonist acting at the polyamine site, does not induce neurotoxic effects on rat cortical neurons. Neuroscience letters, 1992, Mar-30, Volume: 137, Issue:2 Topics: Animals; Biogenic Polyamines; Cerebral Cortex; Cytoplasm; Dizocilpine Maleate; In Vitro Techniques; Male; Microscopy, Electron; N-Methylaspartate; Neurons; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Vacuoles	1992
Competitive and noncompetitive antagonists at N-methyl-D-aspartate receptors protect against methamphetamine-induced dopaminergic damage in mice. The Journal of pharmacology and experimental therapeutics, 1991, Volume: 256, Issue:2 Topics: Amino Acids; Animals; Corpus Striatum; Dizocilpine Maleate; Male; Methamphetamine; Mice; N-Methylaspartate; Pipecolic Acids; Piperidines; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate; Tyrosine 3-Monooxygenase	1991
Ifenprodil and SL 82.0715 as cerebral antiischemic agents. III. Evidence for antagonistic effects at the polyamine modulatory site within the N-methyl-D-aspartate receptor complex. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 253, Issue:2 Topics: Adrenergic alpha-Antagonists; Animals; Aspartic Acid; Binding Sites; Binding, Competitive; Brain; Cells, Cultured; Drug Interactions; Female; Glycine; Male; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred Strains; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine; Spermine; Spinal Cord	1990
Ifenprodil and SL 82.0715 potently inhibit binding of [3H](+)-3-PPP to sigma binding sites in rat brain. Neuroscience letters, 1990, Aug-14, Volume: 116, Issue:1-2 Topics: Animals; Binding, Competitive; Brain; Dopamine Agents; Kinetics; Male; Piperidines; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, sigma; Tritium	1990
The pharmacotherapy of focal cortical ischaemia in the mouse. Brain research, 1990, Jul-09, Volume: 522, Issue:2 Topics: Animals; Calcium Channel Blockers; Cell Survival; Cyclandelate; Ischemic Attack, Transient; Male; Mice; Molecular Structure; N-Methylaspartate; Piperidines; Platelet Activating Factor; Receptors, GABA-A; Receptors, Opioid; Receptors, sigma; Vincamine	1990
Ifenprodil and SL 82.0715 are antagonists at the polyamine site of the N-methyl-D-aspartate (NMDA) receptor. European journal of pharmacology, 1989, May-30, Volume: 164, Issue:3 Topics: Adrenergic alpha-Antagonists; Animals; Brain Chemistry; Glutamates; Male; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spermidine	1989
Ifenprodil and SL 82.0715 antagonize N-methyl-D-aspartate (NMDA)-coupled glycine receptor responses in vivo. European journal of pharmacology, 1989, Sep-01, Volume: 168, Issue:1 Topics: Adrenergic alpha-Antagonists; Animals; Cerebellum; Cyclic GMP; Glycine; Injections; Male; Mice; Piperidines; Receptors, Amino Acid; Receptors, Cell Surface; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Serine; Time Factors	1989
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. I. Evidence for efficacy in models of focal cerebral ischemia. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Aspartic Acid; Brain Ischemia; Cats; Female; Male; Models, Cardiovascular; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Vasoconstriction	1988
Ifenprodil and SL 82.0715 as cerebral anti-ischemic agents. II. Evidence for N-methyl-D-aspartate receptor antagonist properties. The Journal of pharmacology and experimental therapeutics, 1988, Volume: 247, Issue:3 Topics: Animals; Aspartic Acid; Brain Ischemia; Cells, Cultured; Cerebellum; Corpus Striatum; Cyclic GMP; Dopamine; Harmaline; In Vitro Techniques; Mice; N-Methylaspartate; Phencyclidine; Piperazines; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Neurotransmitter; Spinal Cord	1988
NMDA receptor subtype selectivity: eliprodil, polyamine spider toxins, dextromethorphan, and desipramine selectively block NMDA-evoked striatal acetylcholine but not spermidine release. Journal of neurochemistry, 1995, Volume: 64, Issue:5 Topics: Acetylcholine; Animals; Corpus Striatum; Desipramine; Dextromethorphan; Indoleacetic Acids; N-Methylaspartate; Phenols; Phenylacetates; Piperidines; Polyamines; Rats; Receptors, N-Methyl-D-Aspartate; Spermidine; Spider Venoms	1995
Interactions of erythro-ifenprodil, threo-ifenprodil, erythro-iodoifenprodil, and eliprodil with subtypes of sigma receptors. European journal of pharmacology, 1995, Feb-06, Volume: 273, Issue:3 Topics: Animals; Binding, Competitive; Drug Interactions; In Vitro Techniques; Kinetics; Ligands; Male; Pentazocine; Piperidines; Rats; Rats, Inbred F344; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Stereoisomerism	1995
Rewarding and aversive effects of ethanol: interplay of GABA, glutamate and dopamine. Alcohol and alcoholism (Oxford, Oxfordshire). Supplement, 1993, Volume: 2 Topics: Alcoholism; Animals; Aversive Therapy; Dizocilpine Maleate; Dopamine; Electrophysiology; Ethanol; gamma-Aminobutyric Acid; Glutamic Acid; Limbic System; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reward; Synaptic Transmission	1993
Effect of eliprodil, an NMDA receptor antagonist acting at the polyamine modulatory site, on local cerebral glucose use in the rat in the rat brain. Brain research, 1994, Nov-21, Volume: 664, Issue:1-2 Topics: Animals; Biogenic Polyamines; Brain; Glucose; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1994
Evaluation of the reinforcing effects of eliprodil in rhesus monkeys and its discriminative stimulus effects in rats. Drug and alcohol dependence, 1994, Volume: 35, Issue:3 Topics: Animals; Appetitive Behavior; Brain; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Female; Injections, Intravenous; Macaca mulatta; Male; Motivation; N-Methylaspartate; Phencyclidine; Piperidines; Rats; Rats, Wistar; Reinforcement Schedule; Self Administration	1994
The NMDA receptor antagonist eliprodil (SL 82.0715) blocks voltage-operated Ca2+ channels in rat cultured cortical neurons. European journal of pharmacology, 1994, May-23, Volume: 257, Issue:3 Topics: Animals; Calcium Channels; Cells, Cultured; Cerebral Cortex; Electrophysiology; Neurons; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate	1994
Prevention by eliprodil (SL 82.0715) of traumatic brain damage in the rat. Existence of a large (18 h) therapeutic window. Brain research, 1993, Aug-20, Volume: 620, Issue:1 Topics: Animals; Autoradiography; Benzodiazepines; Binding Sites; Brain; Brain Injuries; Dizocilpine Maleate; Drug Administration Schedule; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Time Factors	1993
Antidepressant-like actions of the polyamine site NMDA antagonist, eliprodil (SL-82.0715). Pharmacology, biochemistry, and behavior, 1995, Volume: 52, Issue:3 Topics: Adrenergic beta-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Behavior, Animal; Biogenic Polyamines; Brain Chemistry; Down-Regulation; Excitatory Amino Acid Antagonists; Glycine; Imipramine; Kynurenic Acid; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines; Receptors, Glycine	1995
Influence of the rate of intravenous administration of eliprodil (SL 82.0715), a new anti-ischaemic agent, on its distribution in rat plasma and tissues. Journal of pharmacokinetics and biopharmaceutics, 1995, Volume: 23, Issue:2 Topics: Animals; Brain; Chromatography, High Pressure Liquid; Excitatory Amino Acid Antagonists; Infusions, Intravenous; Injections, Intravenous; Male; Models, Biological; Myocardium; Piperidines; Rats; Rats, Sprague-Dawley; Tissue Distribution	1995
Block of P-type Ca2+ channels by the NMDA receptor antagonist eliprodil in acutely dissociated rat Purkinje cells. European journal of pharmacology, 1995, Dec-27, Volume: 294, Issue:1 Topics: Animals; Binding Sites; Cadmium; Calcium Channel Blockers; Dopamine Antagonists; Electrophysiology; Excitatory Amino Acid Antagonists; Fluspirilene; In Vitro Techniques; omega-Agatoxin IVA; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Solutions; Spider Venoms	1995
Motor actions of eliprodil in the normal and monoamine-depleted mouse: a role in the treatment of Parkinson's disease? Journal of neural transmission (Vienna, Austria : 1996), 1996, Volume: 103, Issue:6 Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Animals; Behavior, Animal; Biogenic Monoamines; Disease Models, Animal; Dopamine Agents; Dopamine Agonists; Dose-Response Relationship, Drug; Efferent Pathways; Excitatory Amino Acid Antagonists; Levodopa; Locomotion; Male; Mice; Mice, Inbred Strains; Motor Neurons; Parkinson Disease; Phenethylamines; Piperidines; Receptors, Dopamine D1; Reserpine; Sympatholytics	1996
Neuroprotective effects of 7-nitroindazole in the gerbil model of global cerebral ischaemia. European journal of pharmacology, 1996, Aug-29, Volume: 310, Issue:2-3 Topics: Animals; Brain Ischemia; Disease Models, Animal; Dizocilpine Maleate; Enzyme Inhibitors; Gerbillinae; Indazoles; Male; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Piperidines; Quinoxalines	1996
Eliprodil prevents expression of the 70 kDa heat shock protein in MK801-injured neurones. Pharmacology & toxicology, 1996, Volume: 79, Issue:3 Topics: Animals; Cerebral Cortex; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Heat-Shock Proteins; Molecular Weight; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma	1996
The effects of ifenprodil and eliprodil on voltage-dependent Ca2+ channels and in gerbil global cerebral ischaemia. European journal of pharmacology, 1996, Mar-28, Volume: 299, Issue:1-3 Topics: Animals; Body Temperature; Brain Ischemia; Calcium Channels; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; Male; Patch-Clamp Techniques; Piperidines; Purkinje Cells; Rats; Receptors, N-Methyl-D-Aspartate	1996
Oral administration of glycine and polyamine receptor antagonists blocks ethanol withdrawal seizures. Psychopharmacology, 1996, Volume: 127, Issue:3 Topics: Acoustic Stimulation; Administration, Oral; Animals; Anticonvulsants; Central Nervous System Depressants; Dizocilpine Maleate; Ethanol; Excitatory Amino Acid Antagonists; Male; Motor Activity; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Seizures; Substance Withdrawal Syndrome	1996
Evidence for native NMDA receptor subtype pharmacology as revealed by differential effects on the NMDA-evoked release of striatal neuromodulators: eliprodil, ifenprodil and other native NMDA receptor subtype selective compounds. Neurochemistry international, 1996, Volume: 29, Issue:5 Topics: Animals; Calcium Channel Blockers; Corpus Striatum; Dantrolene; Excitatory Amino Acid Antagonists; In Vitro Techniques; N-Methylaspartate; Neurotransmitter Agents; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Sodium Channel Blockers; Tetrodotoxin	1996
Characterization of haloperidol and trifluperidol as subtype-selective N-methyl-D-aspartate (NMDA) receptor antagonists using [3H]TCP and [3H]ifenprodil binding in rat brain membranes. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:2 Topics: Animals; Binding, Competitive; Brain; Cell Membrane; Female; Haloperidol; Illicit Drugs; Kinetics; Oocytes; Phencyclidine; Piperidines; Radioligand Assay; Rats; Receptors, N-Methyl-D-Aspartate; Recombinant Proteins; Trifluperidol; Xenopus	1997
Antagonist properties of eliprodil and other NMDA receptor antagonists at rat NR1A/NR2A and NR1A/NR2B receptors expressed in Xenopus oocytes. Neuroscience letters, 1997, Feb-21, Volume: 223, Issue:2 Topics: Animals; Binding Sites; Electric Conductivity; Excitatory Amino Acid Antagonists; Female; Patch-Clamp Techniques; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Xenopus	1997
R- and L-type Ca2+ channels are insensitive to eliprodil in rat cultured cerebellar granule neurons. European journal of pharmacology, 1997, Apr-04, Volume: 323, Issue:2-3 Topics: Animals; Barium; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Cerebellum; Drug Interactions; Neurons; Nimodipine; omega-Agatoxin IVA; omega-Conotoxin GVIA; Patch-Clamp Techniques; Peptides; Piperidines; Rats; Spider Venoms	1997
Influence of extracellular pH on inhibition by ifenprodil at N-methyl-D-aspartate receptors in Xenopus oocytes. Neuroscience letters, 1997, Mar-28, Volume: 225, Issue:1 Topics: Animals; Excitatory Amino Acid Antagonists; Haloperidol; Hydrogen-Ion Concentration; Neuroprotective Agents; Nylidrin; Oocytes; Patch-Clamp Techniques; Piperidines; Receptors, N-Methyl-D-Aspartate; Xenopus laevis	1997
EMD 95885, a new eliprodil analogue with higher affinity for the N-methyl-D-aspartate (NMDA) receptor. Die Pharmazie, 1997, Volume: 52, Issue:6 Topics: 2-Amino-5-phosphonovalerate; Animals; Binding, Competitive; Dizocilpine Maleate; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; In Vitro Techniques; Kainic Acid; Kynurenic Acid; Male; Piperidines; Radioligand Assay; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	1997
The NMDA/glycine receptor antagonist, L-701,324, produces discriminative stimuli similar to those of ethanol. European journal of pharmacology, 1997, Jul-30, Volume: 332, Issue:1 Topics: Administration, Oral; Animals; Behavior, Animal; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Ethanol; Excitatory Amino Acid Antagonists; Male; Piperidines; Quinolones; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate	1997
Neuroprotective effects of eliprodil in a rat hippocampal slice hypoxia model. Annals of the New York Academy of Sciences, 1997, Oct-15, Volume: 825 Topics: Animals; Dizocilpine Maleate; Electric Stimulation; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia, Brain; In Vitro Techniques; Long-Term Potentiation; Neuronal Plasticity; Neuroprotective Agents; Piperidines; Rats; Synapses	1997
Neurotoxicity of polyamines and pharmacological neuroprotection in cultures of rat cerebellar granule cells. Experimental neurology, 1997, Volume: 148, Issue:1 Topics: 2-Amino-5-phosphonovalerate; Animals; Apoptosis; Aspartic Acid; Butylated Hydroxytoluene; Cells, Cultured; Cerebellar Cortex; Dizocilpine Maleate; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Female; Free Radical Scavengers; Glutamic Acid; L-Lactate Dehydrogenase; Male; Nerve Tissue Proteins; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Piperidines; Putrescine; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Spermidine; Spermine; Vitamin E	1997
Neuroprotection afforded by a combination of eliprodil and a thrombolytic agent, rt-PA, in a rat thromboembolic stroke model. Brain research, 1997, Nov-21, Volume: 776, Issue:1-2 Topics: Animals; Brain Ischemia; Cerebral Infarction; Cerebrovascular Disorders; Disease Models, Animal; Fibrinolytic Agents; Hemostasis; Male; Neurologic Examination; Neuroprotective Agents; Partial Thromboplastin Time; Piperidines; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Tissue Plasminogen Activator	1997
Modulation of neuronal mitochondrial membrane potential by the NMDA receptor: role of arachidonic acid. Brain research, 1997, Nov-28, Volume: 777, Issue:1-2 Topics: 2-Amino-5-phosphonovalerate; Anesthetics, Local; Animals; Arachidonic Acid; Biomarkers; Cells, Cultured; Cerebellum; Dibucaine; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Flow Cytometry; Fluorescent Dyes; Glycine; Intracellular Membranes; Kynurenic Acid; Membrane Potentials; Mitochondria; N-Methylaspartate; Piperidines; Quinacrine; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rhodamine 123; Rhodamines; Sulfonamides	1997
Eliprodil, a non-competitive, NR2B-selective NMDA antagonist, protects pyramidal neurons in hippocampal slices from hypoxic/ischemic damage. Brain research, 1998, Jan-26, Volume: 782, Issue:1-2 Topics: Animals; Excitatory Amino Acid Antagonists; Hippocampus; Hypoxia; In Vitro Techniques; Ischemia; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley	1998
Nitric oxide synthase inhibitors attenuate phencyclidine-induced disruption of prepulse inhibition. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 1998, Volume: 19, Issue:1 Topics: Acoustic Stimulation; Animals; Biguanides; Biogenic Polyamines; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Indazoles; Inhibition, Psychological; Male; Nitric Oxide Synthase; Nitroarginine; Phencyclidine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reflex, Startle	1998
Neuroprotective effect of eliprodil: attenuation of a conditioned freezing deficit induced by traumatic injury of the right parietal cortex in the rat. Journal of neurotrauma, 1998, Volume: 15, Issue:7 Topics: Analysis of Variance; Animals; Brain Injuries; Cognition Disorders; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Fear; Male; Neuroprotective Agents; Parietal Lobe; Piperidines; Rats; Rats, Sprague-Dawley; Time and Motion Studies; Time Factors	1998
The effect of eliprodil on the evolution of a focal cerebral ischaemia in vivo. European journal of pharmacology, 1998, Jul-03, Volume: 352, Issue:1 Topics: Animals; Brain Ischemia; Excitatory Amino Acid Antagonists; Magnetic Resonance Imaging; Male; Multivariate Analysis; Piperidines; Radiography; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate	1998
Place conditioning of mice with the NMDA receptor antagonists, eliprodil and dizocilpine. European journal of pharmacology, 1998, Dec-04, Volume: 362, Issue:2-3 Topics: Animals; Behavior, Animal; Conditioning, Psychological; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Housing, Animal; Injections, Intraperitoneal; Male; Mice; Mice, Inbred Strains; Piperidines; Receptors, N-Methyl-D-Aspartate; Social Environment; Stress, Physiological	1998
Antiparkinsonian actions of blockade of NR2B-containing NMDA receptors in the reserpine-treated rat. Experimental neurology, 1999, Volume: 155, Issue:1 Topics: Animals; Antiparkinson Agents; Binding, Competitive; Corpus Striatum; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Parkinson Disease, Secondary; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Reserpine	1999
Sample size review in a head injury trial with ordered categorical responses. Statistics in medicine, 1998, Dec-30, Volume: 17, Issue:24 Topics: Craniocerebral Trauma; Glasgow Coma Scale; Humans; Models, Statistical; Piperidines; Prognosis; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Sample Size; Treatment Outcome	1998
Eliprodil stimulates CNS myelination: new prospects for multiple sclerosis? Neurology, 1999, Jan-15, Volume: 52, Issue:2 Topics: Animals; Axons; Central Nervous System; Coculture Techniques; Drug Evaluation, Preclinical; Forecasting; Mice; Multiple Sclerosis; Myelin Sheath; Neurons; Neuroprotective Agents; Oligodendroglia; Piperidines; Receptors, sigma; Stimulation, Chemical; Triiodothyronine	1999
Anticonvulsant effects of eliprodil alone or combined with the glycineB receptor antagonist L-701,324 or the competitive NMDA antagonist CGP 40116 in the amygdala kindling model in rats. Neuropharmacology, 1999, Volume: 38, Issue:2 Topics: 2-Amino-5-phosphonovalerate; Amygdala; Animals; Anticonvulsants; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Kindling, Neurologic; Piperidines; Quinolones; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate	1999
Protection by eliprodil against excitotoxicity in cultured rat retinal ganglion cells. Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:6 Topics: Animals; Cell Death; Cells, Cultured; Drug Combinations; Electric Conductivity; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Glycine; Male; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Retinal Ganglion Cells	1999
Neuroprotective effects of eliprodil in retinal excitotoxicity and ischemia. Investigative ophthalmology & visual science, 1999, Volume: 40, Issue:6 Topics: Animals; Choline O-Acetyltransferase; Electroretinography; Injections; Injections, Intraperitoneal; Ischemia; N-Methylaspartate; Neuroprotective Agents; Neurotoxins; Piperidines; Rats; Rats, Long-Evans; Retina; Retinal Ganglion Cells; Retinal Vessels; Vitreous Body	1999
N-Methyl-D-aspartate receptor antagonists and the development of tolerance to the discriminative stimulus effects of morphine in rats. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 290, Issue:1 Topics: Animals; Discrimination Learning; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Morphine; Narcotics; Piperazines; Piperidines; Pyrrolidinones; Rats; Rats, Long-Evans; Receptors, N-Methyl-D-Aspartate	1999
Human retina contains polyamine sensitive [3H]-ifenprodil binding sites: implications for neuroprotection? The British journal of ophthalmology, 1999, Volume: 83, Issue:2 Topics: Aged; Aged, 80 and over; Biguanides; Binding Sites; Excitatory Amino Acid Antagonists; Humans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Polyamines; Receptors, N-Methyl-D-Aspartate; Retina	1999
Effects of NMDA receptor antagonists on cocaine-conditioned motor activity in rats. European journal of pharmacology, 2000, Mar-03, Volume: 390, Issue:3 Topics: Animals; Cocaine; Conditioning, Operant; Dizocilpine Maleate; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Male; Memantine; Motor Activity; Piperazines; Piperidines; Quinoxalines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate	2000
Decrement in operant performance produced by NMDA receptor antagonists in the rat: tolerance and cross-tolerance. Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:4 Topics: Animals; Conditioning, Operant; Depression, Chemical; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Tolerance; Excitatory Amino Acid Antagonists; Male; Memantine; Piperidines; Psychomotor Performance; Rats; Rats, Wistar; Receptors, Glycine; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Water	2000
Synthesis and resolution of racemic eliprodil and evaluation of the enantiomers of eliprodil as NMDA receptor antagonists. Bioorganic & medicinal chemistry letters, 2000, Jun-19, Volume: 10, Issue:12 Topics: Excitatory Amino Acid Antagonists; Piperidines; Receptors, N-Methyl-D-Aspartate; Stereoisomerism	2000
NMDA receptor antagonists do not block the development of sensitization of catalepsy, but make its expression state-dependent. Behavioural pharmacology, 2001, Volume: 12, Issue:2 Topics: Animals; Conditioning, Classical; Drug Interactions; Excitatory Amino Acid Antagonists; Haloperidol; Male; Phenols; Piperazines; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, N-Methyl-D-Aspartate	2001
Spermidine attenuates the inhibitory effect of ethanol on NMDA-induced neurotoxicity. Naunyn-Schmiedeberg's archives of pharmacology, 2002, Volume: 366, Issue:2 Topics: Analysis of Variance; Animals; Cell Survival; Cells, Cultured; Cerebellum; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; N-Methylaspartate; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spermidine	2002
Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits. Psychopharmacology, 2004, Volume: 175, Issue:2 Topics: Animals; Animals, Newborn; Ethanol; Female; Fetal Alcohol Spectrum Disorders; Learning Disabilities; Male; Neuroprotective Agents; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley	2004
Effect of a neuroprotective drug, eliprodil on cardiac repolarisation: importance of the decreased repolarisation reserve in the development of proarrhythmic risk. British journal of pharmacology, 2004, Volume: 143, Issue:1 Topics: Action Potentials; Animals; Arrhythmias, Cardiac; Barium Compounds; Chlorides; Dogs; Electrocardiography; Electrophysiology; Female; Heart; In Vitro Techniques; Male; Membrane Potentials; Microelectrodes; Neuroprotective Agents; Papillary Muscles; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels, Inwardly Rectifying; Rabbits	2004
The sequential analysis of repeated binary responses: a score test for the case of three time points. Statistics in medicine, 2006, Jul-15, Volume: 25, Issue:13 Topics: Clinical Trials as Topic; Craniocerebral Trauma; Data Interpretation, Statistical; Excitatory Amino Acid Antagonists; Glasgow Outcome Scale; Humans; Models, Biological; Models, Statistical; Piperidines	2006
Adaptation of USP types II and IV controlled release assays for sparingly soluble compounds by direct eluent HPLC analysis. Pharmaceutical development and technology, 2006, Volume: 11, Issue:1 Topics: Algorithms; Buffers; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Delayed-Action Preparations; Excitatory Amino Acid Antagonists; Piperidines; Polytetrafluoroethylene; Solubility	2006
Vitamin B6 prevents isocarbophos-induced vascular dementia in rats through N-methyl-D-aspartate receptor signaling. Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:2 Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cerebrovascular Circulation; Dementia, Vascular; Disks Large Homolog 4 Protein; Excitatory Amino Acid Antagonists; Hippocampus; Hypertension; Malathion; Male; Maze Learning; Memory; Piperidines; Posterior Cerebral Artery; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Ultrasonography, Doppler; Vitamin B 6; Vitamin B Complex	2018
Synthesis and biological evaluation of conformationally restricted GluN2B ligands derived from eliprodil. European journal of medicinal chemistry, 2022, Jul-05, Volume: 237 Topics: Ligands; Piperidines; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tropanes	2022