Compounds > elacridar
Page last updated: 2024-09-03

elacridar and gemfibrozil

elacridar has been researched along with gemfibrozil in 4 studies

Compound Research Comparison

Studies
(elacridar)		Trials
(elacridar)		Recent Studies (post-2010)
(elacridar)		Studies
(gemfibrozil)		Trials
(gemfibrozil)		Recent Studies (post-2010) (gemfibrozil)
28481191,483359297

Protein Interaction Comparison

ProteinTaxonomyelacridar (IC50)gemfibrozil (IC50)
Cytochrome P450 2C8Homo sapiens (human)4.1
Solute carrier organic anion transporter family member 1B3Homo sapiens (human)7.0795
Solute carrier organic anion transporter family member 1B1Homo sapiens (human)4.0738

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lemaire, S; Mingeot-Leclercq, MP; Tulkens, PM; Van Bambeke, F1
Artursson, P; Haglund, U; Karlgren, M; Kimoto, E; Lai, Y; Norinder, U; Vildhede, A; Wisniewski, JR1
Chanteux, H; Michot, JM; Mingeot-Leclercq, MP; Seral, C; Tulkens, PM; Van Bambeke, F1
Caceres, NE; Marquez, B; Mingeot-Leclercq, MP; Tulkens, PM; Van Bambeke, F1

Other Studies

4 other study(ies) available for elacridar and gemfibrozil

ArticleYear
Modulation of the cellular accumulation and intracellular activity of daptomycin towards phagocytized Staphylococcus aureus by the P-glycoprotein (MDR1) efflux transporter in human THP-1 macrophages and madin-darby canine kidney cells.
    Antimicrobial agents and chemotherapy, 2007, Volume: 51, Issue:8

    Topics: Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cell Line; Daptomycin; Dogs; Humans; Kidney; Macrophages; Phagocytosis; Staphylococcus aureus

2007
Classification of inhibitors of hepatic organic anion transporting polypeptides (OATPs): influence of protein expression on drug-drug interactions.
    Journal of medicinal chemistry, 2012, May-24, Volume: 55, Issue:10

    Topics: Atorvastatin; Biological Transport; Drug Interactions; Estradiol; Estrone; HEK293 Cells; Heptanoic Acids; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; In Vitro Techniques; Least-Squares Analysis; Liver; Liver-Specific Organic Anion Transporter 1; Models, Molecular; Multivariate Analysis; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Protein Isoforms; Pyrroles; Solute Carrier Organic Anion Transporter Family Member 1B3; Structure-Activity Relationship; Transfection

2012
Influence of P-glycoprotein inhibitors on accumulation of macrolides in J774 murine macrophages.
    Antimicrobial agents and chemotherapy, 2003, Volume: 47, Issue:3

    Topics: Acridines; Adenosine Triphosphate; Animals; Anti-Bacterial Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Azithromycin; Cell Line; Cyclosporine; Cytosol; Gemfibrozil; Isoquinolines; Lysosomes; Macrophages; Mice; Microscopy, Confocal; Monensin; Probenecid; Tetrahydroisoquinolines; Verapamil

2003
Identification of the efflux transporter of the fluoroquinolone antibiotic ciprofloxacin in murine macrophages: studies with ciprofloxacin-resistant cells.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:6

    Topics: Acridines; Animals; Anti-Infective Agents; Blotting, Western; Cell Line; Chemokines, CC; Ciprofloxacin; Gemfibrozil; Gene Silencing; Macrophage Inflammatory Proteins; Macrophages; Mice; Multidrug Resistance-Associated Proteins; RNA, Messenger; Tetrahydroisoquinolines

2009