egtazic acid has been researched along with wortmannin in 45 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (35.56) | 18.2507 |
| 2000's | 27 (60.00) | 29.6817 |
| 2010's | 2 (4.44) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bellows, DS; Clarke, ID; Diamandis, P; Dirks, PB; Graham, J; Jamieson, LG; Ling, EK; Sacher, AG; Tyers, M; Ward, RJ; Wildenhain, J | 1 |
| McIntyre, TM; Prescott, SM; Reinhold, SL; Zimmerman, GA | 1 |
| Ferby, IM; Kume, K; Sakanaka, C; Shimizu, T; Waga, I | 1 |
| Aoki, Y; Kodama, H; Matsumoto, T; Nakamura, M; Noma, M; Ogasawara, H; Sakanaka, C; Shimizu, T; Tsuji, T | 1 |
| Farndale, RW; Jenner, S; Sage, SO | 1 |
| Aoki, Y; Hirano, D; Kodama, H; Nakamura, M; Ogasawara, H; Sakanaka, C; Shimizu, T; Waga, I | 1 |
| McKinnon, M; Turner, SJ; Ward, SG; Westwick, J | 1 |
| Chellaiah, M; Hruska, K | 1 |
| Cooke, FT; Eguinoa, A; Hawkins, P; Stephens, LR; Walters, RJ | 1 |
| Abe, H; Obinata, T; Okada, K; Takano-Ohmuro, H | 1 |
| Homburg, CH; Ibarrola, I; Kessler, J; Koenderman, L; Roos, D; Schweizer, RC; Verhoeven, AJ; Vossebeld, PJ | 1 |
| Feijge, MA; Heemskerk, JW; Lindhout, T; Reutelingsperger, CP; Vuist, WM | 1 |
| Breu, J; Muchnicki, L; Slack, BE; Wurtman, RJ | 1 |
| Bitar, KN; Ibitayo, AI; Nozu, F; Owyang, C; Tsunoda, Y | 1 |
| Blank, U; David, B; Guérin-Marchand, C; Iannascoli, B; Marchand, F; Pelletier, C; Weyer, A | 1 |
| Sagi-Eisenberg, R; Seger, R; Shefler, I | 1 |
| Araki, Y; Sendo, F; Yu, Y | 1 |
| Jenner, S; Sage, SO | 1 |
| Fong, CW; Lin, SC; Neo, SY; Zhang, Y | 1 |
| Inanami, O; Kuwabara, M; Takahashi, K; Yoshito, A | 1 |
| Kuijpers, TW; Mul, FP; Roos, D; Schippers, E; van den Berg, JM; Weening, JJ | 1 |
| Chien, CS; Chiu, CT; Hsiao, LD; Lin, CC; Shyr, MH; Wang, CC; Yang, CM | 1 |
| Chang, LC; Wang, JP | 1 |
| Inanami, O; Kuwabara, M; Tsuji, M | 1 |
| Arita, N; Fujikawa, H; Kaibuchi, K; Sato, M; Tani, E; Yamaura, I | 1 |
| Låg, M; Refsnes, M; Schwarze, PE; Thoresen, GH; Thrane, EV | 1 |
| Atkinson, BT; Pears, CJ; Stafford, MJ; Watson, SP | 1 |
| Kuwahara, M; Matsui, H; Miyata, S; Mizuno, T; Sugimoto, M; Tsuji, S; Yoshioka, A | 1 |
| Gokina, NI; Osol, G | 1 |
| Mannie, MD; Patel, DM | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Cozzi, MR; De Marco, L; Mazzucato, M; Pradella, P; Ruggeri, ZM | 1 |
| Bazan, NG; Bernatchez, PN; Gélinas, DS; Rollin, S; Sirois, MG | 1 |
| Imai, S; Itoh, M; Okayama, N; Shimizu, M | 1 |
| Beauchamp, MH; Bernier, SG; Bkaily, G; Brault, S; Checchin, D; Chemtob, S; Gobeil, F; Goetzl, EJ; Hou, X; Marrache, AM; Nader, M; Quiniou, C; Ribeiro-da-Silva, A; Sennlaub, F; Vazquez-Tello, A | 1 |
| Combrié, R; Han, Y; Nurden, A; Pasquet, JM | 1 |
| Hamasu, T; Inanami, O; Kuwabara, M; Niwa, K; Ohta, T; Yamamori, T | 1 |
| Cens, T; Charnet, P; Gouin-Charnet, A; Rousset, M; Scamps, F | 1 |
| Balla, A; Balla, T; Tsiomenko, A; Tuymetova, G; Várnai, P | 1 |
| Cheng, CY; Lee, WM; Siu, MK; Wong, CH | 1 |
| Hardy, AR; Hill, DJ; Poole, AW | 1 |
| Hanada, A; Hirano, K; Hirano, M; Kanaide, H; Momota, F; Nomoto, N | 1 |
| Albert, AP; Large, WA; Saleh, SN | 1 |
| Ambily, A; Authi, HS; Authi, KS; Hassock, S; Kassouf, N; Srivastava, S; Watson, S; Watson, SP | 1 |
| Hsieh, CW; Huang, YT; Wung, BS; Yang, PM; Zhang, YQ | 1 |
45 other study(ies) available for egtazic acid and wortmannin
| Article | Year |
|---|---|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Topics: Animals; Cell Survival; Cells, Cultured; Mice; Molecular Structure; Neoplasms; Neurons; Pharmaceutical Preparations; Sensitivity and Specificity; Stem Cells | 2007 |
Activation of human neutrophil phospholipase D by three separable mechanisms.
Topics: Androstadienes; Calcimycin; Calcium; Cell Adhesion; Cell Aggregation; Egtazic Acid; Enzyme Activation; Glycerophospholipids; Humans; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phosphatidic Acids; Phospholipase D; Phospholipases; Protein Kinase C; Tetradecanoylphorbol Acetate; Wortmannin | 1990 |
Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils.
Topics: Androstadienes; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Female; Guinea Pigs; In Vitro Techniques; Kinetics; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Platelet Activating Factor; Tetradecanoylphorbol Acetate; Time Factors; Wortmannin | 1994 |
Identification of two isoforms of mouse neuropeptide Y-Y1 receptor generated by alternative splicing. Isolation, genomic structure, and functional expression of the receptors.
Topics: Alternative Splicing; Amino Acid Sequence; Androstadienes; Animals; Base Sequence; Bone Marrow; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; Chelating Agents; CHO Cells; Cricetinae; DNA Primers; DNA, Complementary; Egtazic Acid; Enzyme Inhibitors; Gene Expression; Gene Library; Humans; Introns; Kinetics; Mice; Molecular Sequence Data; Neuropeptide Y; Pertussis Toxin; Polymerase Chain Reaction; Protein Structure, Secondary; Receptors, Neuropeptide Y; Recombinant Proteins; Transfection; Virulence Factors, Bordetella; Wortmannin | 1995 |
Wortmannin inhibits store-mediated calcium entry and protein tyrosine phosphorylation in human platelets.
Topics: Androstadienes; Blood Platelets; Blood Proteins; Calcium; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Humans; In Vitro Techniques; Kinetics; Phosphodiesterase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Terpenes; Thapsigargin; Wortmannin | 1996 |
Functional coupling of adenosine A2a receptor to inhibition of the mitogen-activated protein kinase cascade in Chinese hamster ovary cells.
Topics: Adenosine; Adenosine-5'-(N-ethylcarboxamide); Androstadienes; Animals; Arachidonic Acid; Base Sequence; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Membrane; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cyclic AMP; DNA Primers; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; Kinetics; Leukocytes; Molecular Sequence Data; Polymerase Chain Reaction; Purinergic P1 Receptor Agonists; Receptors, Purinergic P1; Recombinant Proteins; Signal Transduction; Thrombin; Transfection; Wortmannin | 1996 |
Stimulation of signal transduction pathways by MCP-1 in human monocytes and THP-1 cells.
Topics: Androstadienes; Calcium; Cell Line; Chemokine CCL2; Econazole; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; Kinetics; Monocytes; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Pyrrolidinones; Signal Transduction; Type C Phospholipases; Wortmannin | 1996 |
Osteopontin stimulates gelsolin-associated phosphoinositide levels and phosphatidylinositol triphosphate-hydroxyl kinase.
Topics: Actins; Androstadienes; Animals; Blotting, Western; Chromatography, Thin Layer; Egtazic Acid; Enzyme Inhibitors; Female; Gelsolin; Osteoclasts; Osteopontin; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phospholipids; Phosphoproteins; Phosphotransferases (Alcohol Group Acceptor); Precipitin Tests; Sialoglycoproteins; Time Factors; Wortmannin | 1996 |
Insulin and ATP stimulate actin polymerization in U937 cells by a wortmannin-sensitive mechanism.
Topics: Actins; Adenosine Triphosphate; Androstadienes; Biopolymers; Chelating Agents; Egtazic Acid; Humans; Insulin; Insulin Antagonists; Mitogens; Tumor Cells, Cultured; Wortmannin | 1996 |
Dephosphorylation of cofilin in polymorphonuclear leukocytes derived from peripheral blood.
Topics: Actin Depolymerizing Factors; Androstadienes; Animals; Calcimycin; Calcium; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Ethers, Cyclic; Humans; Ionophores; Marine Toxins; Microfilament Proteins; N-Formylmethionine Leucyl-Phenylalanine; Nerve Tissue Proteins; Neutrophil Activation; Neutrophils; Okadaic Acid; Oxazoles; Phosphatidylinositol 3-Kinases; Phosphoprotein Phosphatases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Swine; Tetradecanoylphorbol Acetate; Wortmannin | 1996 |
Tyrosine phosphorylation-dependent activation of phosphatidylinositide 3-kinase occurs upstream of Ca2+-signalling induced by Fcgamma receptor cross-linking in human neutrophils.
Topics: Androstadienes; Calcium; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphotransferases (Alcohol Group Acceptor); Receptors, IgG; Signal Transduction; Tyrosine; Wortmannin | 1997 |
Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses.
Topics: Androstadienes; Aspirin; Blood Coagulation; Blood Platelets; Calcimycin; Calcium; Cell Membrane; Chelating Agents; Collagen; Egtazic Acid; Enzyme Inhibitors; Estrenes; Fibrinogen; Genistein; Humans; Ion Transport; Membrane Lipids; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Microscopy, Video; P-Selectin; Phosphatidylserines; Phosphorylation; Platelet Adhesiveness; Platelet Aggregation Inhibitors; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Pyrrolidinones; Signal Transduction; Thrombin; Wortmannin | 1997 |
Rapid stimulation of amyloid precursor protein release by epidermal growth factor: role of protein kinase C.
Topics: Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Androstadienes; Aspartic Acid Endopeptidases; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Indoles; Inositol; Inositol Phosphates; Maleimides; Nitriles; Phosphatidylinositols; Phosphotyrosine; Protein Kinase C; Quinazolines; Tumor Cells, Cultured; Tyrphostins; Wortmannin | 1997 |
Src kinase and PI 3-kinase as a transduction pathway in ceramide-induced contraction of colonic smooth muscle.
Topics: Amino Acid Sequence; Androstadienes; Animals; Benzoquinones; Calcium; Chromones; Colon; Egtazic Acid; Enzyme Inhibitors; In Vitro Techniques; Kinetics; Lactams, Macrocyclic; Models, Biological; Molecular Sequence Data; Morpholines; Muscle Contraction; Muscle, Smooth; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein-Tyrosine Kinases; Proto-Oncogene Proteins pp60(c-src); Quinones; Rabbits; Rifabutin; Signal Transduction; Sphingosine; src Homology Domains; Substrate Specificity; Wortmannin | 1998 |
Specific signaling pathways in the regulation of TNF-alpha mRNA synthesis and TNF-alpha secretion in RBL-2H3 mast cells stimulated through the high affinity IgE receptor.
Topics: Androstadienes; Animals; beta-N-Acetylhexosaminidases; Egtazic Acid; Enzyme Inhibitors; Gene Expression; Indoles; Leukemia, Basophilic, Acute; Maleimides; Mast Cells; Phosphoinositide-3 Kinase Inhibitors; Protein Kinase C; Rats; Receptors, IgE; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleases; RNA, Messenger; Signal Transduction; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 1998 |
Gi-mediated activation of mitogen-activated protein kinase (MAPK) pathway by receptor mimetic basic secretagogues of connective tissue-type mast cells: bifurcation of arachidonic acid-induced release upstream of MAPK.
Topics: Androstadienes; Animals; Arachidonic Acids; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Chromones; Connective Tissue Cells; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Histamine Release; In Vitro Techniques; Indole Alkaloids; Inositol Phosphates; Kinetics; Mast Cells; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; p-Methoxy-N-methylphenethylamine; Pertussis Toxin; Phosphotyrosine; Rats; Rats, Wistar; Signal Transduction; Tyrphostins; Vanadates; Virulence Factors, Bordetella; Wortmannin | 1999 |
Tyrosine phosphorylation of a 34-kDa protein induced by cross-linking a novel glycosylphosphatidylinositol-anchored glycoprotein (GPI-80) on human neutrophils that may regulate their adherence and migration.
Topics: Amidohydrolases; Androstadienes; Animals; Cell Adhesion; Cell Adhesion Molecules; Cell Movement; Chelating Agents; Cross-Linking Reagents; Cytochalasin B; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Genistein; GPI-Linked Proteins; Humans; Hydrolases; Indoles; Mice; Mice, Inbred BALB C; Neutrophils; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotyrosine; Signal Transduction; Time Factors; Tyrosine; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2000 |
Two pathways for store-mediated calcium entry in human platelets.
Topics: Androstadienes; Biological Transport; Blood Platelets; Calcium; Calcium Channel Blockers; Calcium Signaling; Chelating Agents; Econazole; Egtazic Acid; Enzyme Inhibitors; Humans; Imidazoles; Ionomycin; Ionophores; Lanthanum; Manganese; Phosphorylation; Protein-Tyrosine Kinases; Thapsigargin; Tyrosine; Wortmannin | 2000 |
Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner.
Topics: Androstadienes; Bucladesine; Calcimycin; Calcineurin; Calcium; Calcium Signaling; Cyclosporine; DNA-Binding Proteins; Egtazic Acid; Enzyme Activation; Humans; Kinetics; Mitogen-Activated Protein Kinases; NFATC Transcription Factors; Nuclear Proteins; Protein Kinase C; Proteins; RGS Proteins; RNA, Messenger; Tacrolimus; Tetradecanoylphorbol Acetate; Thapsigargin; Transcription Factors; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Up-Regulation; Wortmannin | 2000 |
Hydrogen peroxide-induced activation of SAPK/JNK regulated by phosphatidylinositol 3-kinase in Chinese hamster V79 cells.
Topics: Androstadienes; Animals; Bucladesine; Calcium; Cell Line; Chelating Agents; Colforsin; Cricetinae; Cricetulus; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Humans; Hydrogen Peroxide; Immunoblotting; Insulin Receptor Substrate Proteins; JNK Mitogen-Activated Protein Kinases; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Precipitin Tests; Wortmannin | 1999 |
Beta1 integrin activation on human neutrophils promotes beta2 integrin-mediated adhesion to fibronectin.
Topics: Androstadienes; CD18 Antigens; Cell Adhesion; Egtazic Acid; Fibronectins; Humans; Integrin alpha4beta1; Integrins; Macrophage-1 Antigen; Neutrophils; Receptors, Fibronectin; Receptors, Lymphocyte Homing; Tumor Cells, Cultured; Wortmannin | 2001 |
Mechanisms of thrombin-induced MAPK activation associated with cell proliferation in human cultured tracheal smooth muscle cells.
Topics: Androstadienes; Benzoquinones; Blotting, Western; Cell Division; Cells, Cultured; Chelating Agents; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; Genistein; Humans; Indoles; Lactams, Macrocyclic; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Muscle, Smooth; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphorylation; Plasmids; Protein Isoforms; Protein Kinase C; Proto-Oncogene Proteins c-raf; Pyrrolidinones; Quinones; ras Proteins; Rifabutin; Thrombin; Time Factors; Trachea; Transfection; Virulence Factors, Bordetella; Wortmannin | 2001 |
Signal transduction pathways for activation of extracellular signal-regulated kinase by arachidonic acid in rat neutrophils.
Topics: 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Androstadienes; Animals; Arachidonic Acid; Arachidonic Acids; Butadienes; Calcium; Carbazoles; Chelating Agents; Chromones; Cyclooxygenase Inhibitors; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Estrenes; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; Indoles; Lipoxygenase Inhibitors; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Morpholines; Neutrophils; Nitriles; Pertussis Toxin; Phosphatidylinositol Diacylglycerol-Lyase; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Protein Processing, Post-Translational; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Type C Phospholipases; Virulence Factors, Bordetella; Wortmannin | 2001 |
Induction of neurite outgrowth in PC12 cells by alpha -phenyl-N-tert-butylnitron through activation of protein kinase C and the Ras-extracellular signal-regulated kinase pathway.
Topics: Acetylcysteine; Androstadienes; Animals; Cyclic N-Oxides; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Free Radical Scavengers; Indoles; Isoquinolines; Kinetics; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Neurites; Neuroprotective Agents; Nitrogen Oxides; p38 Mitogen-Activated Protein Kinases; PC12 Cells; Protein Kinase C; ras Proteins; Rats; Recombinant Proteins; Signal Transduction; Sulfonamides; Transfection; Wortmannin | 2001 |
Importance of Rho-kinase-mediated phosphorylation of myosin light chain in vasospasm.
Topics: Amides; Androstadienes; Animals; Basilar Artery; Chelating Agents; Dogs; Egtazic Acid; Enzyme Inhibitors; Genistein; Guanine Nucleotide Dissociation Inhibitors; Immunoblotting; Intracellular Signaling Peptides and Proteins; Isoenzymes; Myosin Light Chains; Myosin-Light-Chain Phosphatase; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Vasodilation; Vasospasm, Intracranial; Wortmannin | 2001 |
Mechanisms in fluoride-induced interleukin-8 synthesis in human lung epithelial cells.
Topics: Androstadienes; Benzylamines; Cell Line; Colforsin; Cyclic AMP-Dependent Protein Kinases; Dose-Response Relationship, Drug; Egtazic Acid; Epithelial Cells; Flavonoids; Genistein; Humans; Indoles; Interleukin-8; Isoquinolines; Lung; Maleimides; Okadaic Acid; Pertussis Toxin; Protein Kinase C; Signal Transduction; Sodium Fluoride; Sulfonamides; Tetradecanoylphorbol Acetate; Vanadates; Virulence Factors, Bordetella; Wortmannin | 2001 |
Signalling components underlying platelet aggregation to a Ca2+ ionophore and a phorbol ester.
Topics: Adenosine Diphosphate; Androstadienes; Calcimycin; Calcium Signaling; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Humans; Indoles; Ionophores; Morpholines; Phosphatidylinositol 3-Kinases; Platelet Aggregation; Prostaglandin-Endoperoxide Synthases; Protein Kinase C; Serotonin; Signal Transduction; Tetradecanoylphorbol Acetate; Thromboxanes; Type C Phospholipases; Wortmannin | 2001 |
Platelet shape changes and adhesion under high shear flow.
Topics: Androstadienes; Arginine; Blood Platelets; Calcium; Cell Movement; Cytoplasm; Egtazic Acid; Humans; Microscopy, Electron, Scanning; Microscopy, Fluorescence; Pipecolic Acids; Platelet Adhesiveness; Signal Transduction; Stress, Mechanical; Sulfonamides; Wortmannin | 2002 |
Actin cytoskeletal modulation of pressure-induced depolarization and Ca(2+) influx in cerebral arteries.
Topics: Actins; Androstadienes; Animals; Blood Pressure; Bridged Bicyclo Compounds, Heterocyclic; Calcium; Cerebral Arteries; Cytochalasin D; Cytoskeleton; Egtazic Acid; Endothelium, Vascular; In Vitro Techniques; Ionomycin; Male; Marine Toxins; Membrane Potentials; Muscle, Smooth, Vascular; Nifedipine; Nigericin; Rats; Rats, Inbred WKY; Thiazoles; Thiazolidines; Vasoconstriction; Wortmannin | 2002 |
Intercellular exchange of class II major histocompatibility complex/peptide complexes is a conserved process that requires activation of T cells but is constitutive in other types of antigen presenting cell.
Topics: Androstadienes; Animals; Antibodies, Monoclonal; Antigen-Presenting Cells; B-Lymphocytes; Basophils; Cell Adhesion Molecules; Cell Line, Transformed; Clone Cells; Egtazic Acid; Encephalomyelitis, Autoimmune, Experimental; Histocompatibility Antigens Class II; Humans; Immune Tolerance; Jurkat Cells; Lymphocyte Activation; Lymphocyte Function-Associated Antigen-1; Macrophages; Mice; Mice, Inbred BALB C; Organ Specificity; Rats; Rats, Inbred Lew; Receptors, Antigen, T-Cell; Species Specificity; Spleen; T-Lymphocyte Subsets; Tumor Cells, Cultured; Wortmannin | 2001 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
Sequential cytoplasmic calcium signals in a 2-stage platelet activation process induced by the glycoprotein Ibalpha mechanoreceptor.
Topics: Androstadienes; Blood Platelets; Calcium; Calcium Signaling; Egtazic Acid; Humans; Kinetics; Mechanoreceptors; Nitroprusside; Platelet Activation; Platelet Adhesiveness; Platelet Glycoprotein GPIb-IX Complex; Recombinant Proteins; Reference Values; von Willebrand Factor; Wortmannin | 2002 |
Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways.
Topics: 1-Methyl-3-isobutylxanthine; Androstadienes; Animals; Calcimycin; Calcium; Cattle; Cells, Cultured; Chelating Agents; Chromones; Cyclic GMP; Diterpenes; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Growth Factors; Endothelium, Vascular; Enzyme Inhibitors; Ginkgolides; Indoles; Intercellular Signaling Peptides and Proteins; Ionophores; Lactones; Lymphokines; Maleimides; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitroprusside; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Platelet Activating Factor; Platelet Membrane Glycoproteins; Protein Kinase C; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Serine; Signal Transduction; Time Factors; Type C Phospholipases; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Wortmannin | 2002 |
Increased intracellular calcium activates serum and glucocorticoid-inducible kinase 1 (SGK1) through a calmodulin-calcium calmodulin dependent kinase kinase pathway in Chinese hamster ovary cells.
Topics: Androstadienes; Animals; Calcium Signaling; Calcium-Calmodulin-Dependent Protein Kinase Kinase; Calcium-Transporting ATPases; Chelating Agents; CHO Cells; Cricetinae; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Immediate-Early Proteins; Insulin; Ionomycin; Nuclear Proteins; Plasma Membrane Calcium-Transporting ATPases; Protein Serine-Threonine Kinases; Sulfonamides; Thapsigargin; Transfection; Wortmannin | 2003 |
Modulation of pro-inflammatory gene expression by nuclear lysophosphatidic acid receptor type-1.
Topics: Androstadienes; Animals; Blotting, Western; Calcium; Caveolin 1; Caveolins; Cell Nucleus; Cell-Free System; Cells, Cultured; Chelating Agents; Clathrin; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Gene Expression Regulation; Immunoblotting; Liver; Microcirculation; Microscopy, Electron; Microscopy, Fluorescence; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Pertussis Toxin; Phosphoinositide-3 Kinase Inhibitors; Phospholipases A; Phospholipases A2; Precipitin Tests; Protein Binding; Protein-Tyrosine Kinases; Rats; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Subcellular Fractions; Swine; Time Factors; Transfection; Tumor Cells, Cultured; Wortmannin | 2003 |
Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium.
Topics: Actins; Androstadienes; Blood Platelets; Calcium; Chelating Agents; Cytochalasin D; Cytoskeleton; Egtazic Acid; Enzyme Inhibitors; Flow Cytometry; Humans; Hydrolysis; Ligands; Microscopy, Fluorescence; Myosins; Peptides; Phosphatidylinositol 3-Kinases; Platelet Glycoprotein GPIb-IX Complex; Precipitin Tests; Protein Structure, Tertiary; Receptor, PAR-1; Receptors, Thrombin; Time Factors; Wortmannin | 2003 |
Redox regulation of PI3K/Akt and p53 in bovine aortic endothelial cells exposed to hydrogen peroxide.
Topics: Androstadienes; Animals; Antioxidants; Aorta; Apoptosis; bcl-2-Associated X Protein; Calcium; Caspase 3; Caspase 9; Caspases; Cattle; Cells, Cultured; Chelating Agents; Cystine; DNA Fragmentation; Dose-Response Relationship, Drug; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Gene Expression Regulation; Hydrogen Peroxide; Immunoblotting; Models, Biological; Oxidation-Reduction; Oxidative Stress; Phosphatidylinositol 3-Kinases; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-bcl-2; Signal Transduction; Time Factors; Tumor Suppressor Protein p53; Wortmannin | 2003 |
Ca2+ and phosphatidylinositol 4,5-bisphosphate stabilize a Gbeta gamma-sensitive state of Ca V2 Ca 2+ channels.
Topics: Androstadienes; Animals; Baclofen; Calcium; Calcium Channels, N-Type; Cell Membrane; Chelating Agents; Cytoskeleton; Cytosol; DNA, Complementary; Dose-Response Relationship, Drug; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Electrophysiology; Enzyme Inhibitors; Ganglia, Spinal; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Membrane Potentials; Mice; Neurons; Oocytes; Phosphatidylinositol 4,5-Diphosphate; Phospholipids; Phosphorylation; Protein Binding; Protein Structure, Tertiary; Time Factors; Wortmannin; Xenopus; Xenopus laevis | 2004 |
A plasma membrane pool of phosphatidylinositol 4-phosphate is generated by phosphatidylinositol 4-kinase type-III alpha: studies with the PH domains of the oxysterol binding protein and FAPP1.
Topics: 1-Phosphatidylinositol 4-Kinase; Acetylcysteine; Adaptor Proteins, Signal Transducing; Androstadienes; Animals; Blotting, Western; Calcium; Carrier Proteins; Cell Membrane; Chelating Agents; Chlorocebus aethiops; COS Cells; Cytoplasm; DNA; Down-Regulation; Egtazic Acid; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Golgi Apparatus; Green Fluorescent Proteins; Humans; Immunohistochemistry; Ionomycin; Ionophores; Lipid Metabolism; Microscopy, Confocal; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Receptors, Steroid; RNA, Small Interfering; Subcellular Fractions; Time Factors; Transfection; Wortmannin | 2005 |
Sertoli-germ cell anchoring junction dynamics in the testis are regulated by an interplay of lipid and protein kinases.
Topics: Androstadienes; Animals; Cell Communication; Cell Culture Techniques; Chelating Agents; Coculture Techniques; Culture Media; Culture Media, Serum-Free; Cytoskeleton; Edetic Acid; Egtazic Acid; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Germ Cells; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Integrin beta1; Lipid Metabolism; Lipids; Male; Microscopy, Electron; Microscopy, Fluorescence; Models, Biological; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Sertoli Cells; Signal Transduction; Spermatogenesis; Testis; Time Factors; Tyrosine; Wortmannin | 2005 |
Evidence that the purinergic receptor P2Y12 potentiates platelet shape change by a Rho kinase-dependent mechanism.
Topics: Actins; Adenosine Diphosphate; Adenosine Monophosphate; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Androstadienes; Blood Platelets; Calcium; Cell Shape; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Membrane Proteins; Myosins; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Platelet Activation; Protein Serine-Threonine Kinases; Pseudopodia; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Receptors, Purinergic P2Y1; Receptors, Purinergic P2Y12; rho-Associated Kinases; Second Messenger Systems; Wortmannin | 2005 |
Distinct Ca2+ requirement for NO production between proteinase-activated receptor 1 and 4 (PAR1 and PAR4) in vascular endothelial cells.
Topics: Androstadienes; Animals; Calcium; Cattle; Cell Line; Cells, Cultured; Chromones; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Cells; Enzyme Inhibitors; GTP-Binding Protein alpha Subunits; Humans; Morpholines; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Oligopeptides; Peptides, Cyclic; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Receptor, PAR-1; Receptors, Thrombin; Swine; Wortmannin | 2007 |
Obligatory role for phosphatidylinositol 4,5-bisphosphate in activation of native TRPC1 store-operated channels in vascular myocytes.
Topics: 1-Phosphatidylinositol 4-Kinase; Androstadienes; Animals; Antibodies, Phospho-Specific; Benzophenanthridines; Chelating Agents; Chromones; Egtazic Acid; Immunologic Factors; Immunoprecipitation; Indoles; Membrane Potentials; Morpholines; Myocytes, Smooth Muscle; Phosphatidylinositol 4,5-Diphosphate; Portal Vein; Protein Kinase C; Protein Kinase Inhibitors; Rabbits; TRPC Cation Channels; Wortmannin | 2009 |
Phosphatidylinositol-3,4,5-trisphosphate stimulates Ca(2+) elevation and Akt phosphorylation to constitute a major mechanism of thromboxane A2 formation in human platelets.
Topics: Androstadienes; Blood Platelets; Calcium; Egtazic Acid; Enzyme-Linked Immunosorbent Assay; Fura-2; Humans; Intracellular Signaling Peptides and Proteins; Phosphatidylinositol Phosphates; Phospholipase C gamma; Phosphorylation; Platelet Aggregation; Protein Kinase Inhibitors; Protein-Tyrosine Kinases; Proto-Oncogene Proteins c-akt; Syk Kinase; Thromboxane A2; Wortmannin | 2015 |
Carbon monoxide releasing molecule induces endothelial nitric oxide synthase activation through a calcium and phosphatidylinositol 3-kinase/Akt mechanism.
Topics: Androstadienes; Animals; Calcium; Carbon Monoxide; Cattle; Chromones; Egtazic Acid; Endothelial Cells; Endothelium, Vascular; Morpholines; Nitric Oxide Synthase Type III; Organometallic Compounds; Phosphatidylinositol 3-Kinase; Phosphorylation; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Time Factors; Wortmannin | 2016 |