egtazic acid has been researched along with calpain in 88 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (19.32) | 18.7374 |
| 1990's | 26 (29.55) | 18.2507 |
| 2000's | 35 (39.77) | 29.6817 |
| 2010's | 10 (11.36) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Horie, S; Ishii, H; Kazama, M; Nakagawa, M; Suzuki, Y | 1 |
| Inoue, M; Ishii, H; Kazama, M; Kuboki, M; Morikawa, M; Suzuki, Y | 1 |
| Mortensen, AM; Novak, RF | 1 |
| Kawasaki, H; Kobayashi, Y; Matsushima, K; Oppenheim, JJ; Saido, T; Yamamoto, K | 1 |
| Bevers, EM; Comfurius, P; Schroit, AJ; Senden, JM; Tilly, RH; Zwaal, RF | 1 |
| Banik, NL; Hogan, EL; McAlhaney, WW | 1 |
| Bernard, CC; Carnegie, PR; Kerlero de Rosbo, N | 1 |
| Ballard, FJ; Hopgood, MF; Knowles, SE | 1 |
| Hayashi, M; Inomata, M; Kawashima, S; Nakamura, M; Saito, Y | 1 |
| Inoki, R; Kudo, T; Wei, EQ | 1 |
| Fujihara, M; Hoshino, N; Kimura, I; Kimura, M; Kobayashi, S | 1 |
| Exton, JH; Lynch, CJ; Sobo, GE | 1 |
| Melloni, E; Michetti, M; Pontremoli, S; Salamino, F; Sparatore, B | 1 |
| Bodwell, JE; Holbrook, NJ; Mendel, DB | 1 |
| Iizuka, H; Matsuo, S; Ohkawara, A | 1 |
| Goris, J; Merlevede, W; Waelkens, E | 1 |
| Schollmeyer, JE | 1 |
| Nixon, RA; Quackenbush, R; Vitto, A | 1 |
| Connold, AL; Evers, JV; Vrbová, G | 1 |
| Swanson, GJ; Vrbová, G | 1 |
| Miyatake, T; Sato, S; Yanagisawa, K | 1 |
| Rabinowitz, M; Reddy, MK; Zak, R | 1 |
| Hajimohammadreza, I; Posner, A; Raser, KJ; Wang, KK; Yuen, PW | 1 |
| Ariyoshi, H; Druker, BJ; Oda, A; Salzman, EW; Smith, M | 1 |
| Beyreuther, K; Evin, G; Li, QX; Masters, CL; Multhaup, G; Small, DH | 1 |
| Kobayashi, Y; Watanabe, N | 1 |
| Lin, RC; Matesic, DF | 1 |
| Croall, DE; Hemler, ME; Potts, AJ | 1 |
| Novak, RF; Runge-Morris, M | 1 |
| Homma, Y; Ikeuchi, Y; Kim, K; Suzuki, A | 1 |
| Fukai, F; Katayama, T; Ohtani, T; Ueki, M | 1 |
| Buroker-Kilgore, M; Raser, KJ; Wang, KK | 1 |
| Banik, NL; Deshpande, RV; Goust, JM; Hogan, EL | 1 |
| Barnoy, S; Glasner, T; Kosower, NS | 1 |
| Cole, D; Durham, J; Gebrosky, N; Mawhinney, M; Stetter-Neel, C | 1 |
| Lu, Q; Mellgren, RL; Xie, ZJ; Zhang, W | 1 |
| Baouz, S; Bernardi, A; Jacquet, E; Parmeggiani, A | 1 |
| Imajoh-Ohmi, S; Jackson, SP; Kulkarni, S; Saido, TC; Salem, HH; Schoenwaelder, SM; Yamao-Harigaya, W | 1 |
| Feng, W; Shevchenko, S; Shoshan-Barmatz, V; Varsanyi, M | 1 |
| Barnoy, S; Glaser, T; Kosower, NS | 1 |
| Gnegy, ME; McGinnis, KM; Wang, KK | 1 |
| Endo, S; Ishiguro, S; Tamai, M | 1 |
| Gurd, JW; Lombroso, PJ; Nguyen, TH; Paul, S; Xu, Y | 1 |
| Du, S; Lee, EB; Lee, YB; Markelonis, GJ; Oh, TH; Rhim, H | 1 |
| Friedlander, RM; Kwon, YT; Lee, MS; Li, M; Peng, J; Tsai, LH | 1 |
| Chen, M; Durr, J; Fernandez, HL | 1 |
| Culver, DG; Glass, JD; Wang, MS; Wu, Y | 1 |
| Gautier, F; Grégoire, M; Harb, J; Irminger-Finger, I; Meflah, K | 1 |
| Kobayashi, H; Shibuya, I; Shiraishi, S; Toyohira, Y; Uezono, Y; Wada, A; Yamamoto, R; Yanagita, T; Yokoo, H | 1 |
| Mosevitsky, MI; Zakharov, VV | 1 |
| Banno, Y; Nakashima, S; Nishimura, Y; Nozawa, Y; Sakai, N; Sawada, M; Yamakawa, H; Yoshimura, S | 1 |
| Eichhorst, ST; Krammer, PH; Müller, M; Nakayama, N | 1 |
| Aki, T; Fujimiya, T; Yoshida, K | 1 |
| Anagli, J; Hotchkiss, RS; Strasberg, SM; Topp, SA; Upadhya, GA | 1 |
| Chaudhuri, P; Colles, SM; Damron, DS; Graham, LM | 1 |
| He, Z; Hoopfer, E; Kim, A; Liu, Q; Luo, L; Mitchison, T; Wang, J; Watts, R; Zhai, Q | 1 |
| Tai, PC; Wu, KH | 1 |
| Chen, M; Fernandez, HL | 1 |
| Cui, ZG; Feril, LB; Hayashi, Y; Kasuya, M; Kondo, T; Ogawa, R; Teranishi, H; Zhao, QL | 1 |
| Brooks, WH; Hood, JL; Roszman, TL | 1 |
| Blair, HC; Glading, A; Satish, L; Wells, A | 1 |
| Chakraborty, C; Dixon, SJ; Lala, PK; Nicola, C; Timoshenko, AV | 1 |
| Aburaya, M; Hoshino, T; Ishihara, T; Katsu, T; Mizushima, T; Namba, T; Suzuki, K; Tanaka, K; Tomisato, W; Tsutsumi, S | 1 |
| de Chaves, EI; Saavedra, L; Song, MS | 1 |
| Baba, HA; Heusch, G; Keul, P; Levkau, B; Lucke, S; von Wnuck Lipinski, K; Wohlschlaeger, J | 1 |
| Akiyoshi, T; Juman, S; Kitada, Y; Matsuyama, K; Matzno, S; Nakabayashi, T; Shinozuka, K; Tanaka, N; Yasuda, S | 1 |
| Azuma, M; Ma, H; Shearer, TR | 1 |
| Asai, M; Hayashi, H; Katoh, H; Nakano, T; Ozeki, M; Satoh, H; Watanabe, H | 1 |
| Kotake, Y; Nakatsu, Y; Ohta, S | 1 |
| Ferreira, A; Kelly, BL | 1 |
| Choi, SE; Jung, MW; Kang, Y; Kim, HE; Min, SH; Shin, HC | 1 |
| Chau, GY; Chau, YP; Chien, CL; Don, MJ; Kung, HN; Lu, KS | 1 |
| Aroca-Aguilar, JD; Coca-Prados, M; Escribano, J; Martínez-Redondo, F; Sánchez-Sánchez, F | 1 |
| Aggeli, IK; Beis, I; Gaitanaki, C | 1 |
| Glicksman, MA; Huang, MM; Michaelis, ML; Ni, J; Schuman, ER; Seyb, KI | 1 |
| Baugher, KM; Bernier, M; Camilli, TC; Earley, R; Elias, EG; Fiori, JL; Frank, BP; French, AD; Hasskamp, JH; Hoek, KS; Indig, FE; O'Connell, MP; Taub, DD; Weeraratna, AT | 1 |
| Liu, Z; Wang, S; Yang, Y; Zhang, M; Zhou, H | 1 |
| O'Day, DH; Poloz, YO | 1 |
| Chakraborti, S; Chakraborti, T; Kar, P; Samanta, K | 1 |
| Hiratsuka, T; Katayama, T; Kuwahara, R; Matsuzaki, S; Tohyama, M | 1 |
| Baudry, M; Bi, X; Jourdi, H; Qin, Q; Rostamiani, K; Zadran, S | 1 |
| Khan, S; Sharma, S; Verma, G | 1 |
| Beebe, SJ; Ren, W | 1 |
| Hossain, MM; Richardson, JR | 1 |
| An, J; He, Y; Hou, J; Li, Y; Liu, X; Wang, X; Wang, Z; Yang, L | 1 |
| Annunziato, L; Boscia, F; Cantile, M; D'Avanzo, C; Di Renzo, G; Esposito, A; Herchuelz, A; Molinaro, P; Pannaccione, A; Scorziello, A; Secondo, A; Sirabella, R; Sokolow, S | 1 |
| Chen, M; Nguyen, HT | 1 |
| Hou, CH; Hou, SM; Lin, FL; Liu, JF | 1 |
88 other study(ies) available for egtazic acid and calpain
| Article | Year |
|---|---|
Participation of calpain I activation in the ATP release reaction of platelets stimulated with thrombin.
Topics: Adenosine Triphosphate; Antibodies; Blood Platelets; Calpain; Cell Membrane; Egtazic Acid; Enzyme Activation; Humans; Platelet Activation; Thrombin; Time Factors | 1992 |
Activation of calpain I in thrombin-stimulated platelets is regulated by the initial elevation of the cytosolic Ca2+ concentration.
Topics: Adult; Blood Platelets; Calcium; Calpain; Cytosol; Egtazic Acid; Enzyme Activation; Fluorescent Dyes; Fura-2; Humans; Immunoblotting; Immunodiffusion; In Vitro Techniques; Kinetics; Thrombin | 1992 |
Enhanced proteolysis and changes in membrane-associated calpain following phenylhydrazine insult to human red cells.
Topics: Amino Acids; Antibodies; Antioxidants; Blood Proteins; Calpain; Chromatography, High Pressure Liquid; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Erythrocyte Membrane; Erythrocytes; Free Radical Scavengers; Free Radicals; Hemoglobins; Humans; Immunoblotting; Membrane Proteins; Oxygen; Phenylhydrazines | 1991 |
Identification of calcium-activated neutral protease as a processing enzyme of human interleukin 1 alpha.
Topics: Calcium; Calpain; Cell Line; Egtazic Acid; Humans; Interleukin-1; Ionomycin; Kinetics; Lipopolysaccharides; Methionine; Monocytes; Protein Processing, Post-Translational; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1990 |
Loss of membrane phospholipid asymmetry in platelets and red cells may be associated with calcium-induced shedding of plasma membrane and inhibition of aminophospholipid translocase.
Topics: Adenosine Triphosphate; Blood Platelets; Calcimycin; Calcium; Calpain; Carrier Proteins; Cell Compartmentation; Egtazic Acid; Enzyme Activation; Erythrocyte Membrane; Humans; In Vitro Techniques; Membrane Lipids; Membrane Proteins; Phosphatidylserines; Phospholipid Transfer Proteins; Phospholipids; Platelet Activation; Sulfhydryl Compounds; Thromboplastin | 1990 |
Calcium-stimulated proteolysis in myelin: evidence for a Ca2+-activated neutral proteinase associated with purified myelin of rat CNS.
Topics: Animals; Calcium; Calpain; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Freezing; Hydrogen-Ion Concentration; Myelin Basic Protein; Myelin Proteins; Myelin Sheath; Octoxynol; Peptide Hydrolases; Polyethylene Glycols; Rats; Rats, Inbred Strains; Spinal Cord | 1985 |
Quantitative electroimmunoblotting study of the calcium-activated neutral protease in human myelin.
Topics: Brain; Calcium; Calpain; Edetic Acid; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Immunologic Techniques; Mercaptoethanol; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Temperature | 1986 |
Proteolysis of N-ethylmaleimide-modified aldolase loaded into erythrocyte ghosts: prevention by inhibitors of calpain.
Topics: Calpain; Egtazic Acid; Erythrocyte Membrane; Ethylmaleimide; Fructose-Bisphosphate Aldolase; HeLa Cells; Humans; Hydrolysis; Microinjections | 1989 |
Properties of erythrocyte membrane binding and autolytic activation of calcium-activated neutral protease.
Topics: Animals; Blood Proteins; Calcium; Calcium-Binding Proteins; Calpain; Caseins; Chickens; Egtazic Acid; Enzyme Activation; Erythrocyte Membrane; Immunoblotting; Kinetics; Leupeptins; Macromolecular Substances; Membrane Proteins; Mice; Molecular Weight; Rabbits; Vimentin | 1989 |
Activation of calcium ion-dependent proteinases by bradykinin in dental pulp of the rat.
Topics: Animals; Bradykinin; Calcium; Calpain; Dental Pulp; Egtazic Acid; Enzyme Activation; Esters; Gabexate; Guanidines; Kinetics; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1989 |
Diabetic state-induced activation of calcium-activated neutral proteinase in mouse skeletal muscle.
Topics: Actinin; Animals; Calcium; Calpain; Cell Membrane; Creatine Kinase; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Edetic Acid; Egtazic Acid; Electrophoresis; Enzyme Activation; Leucine; Male; Mice; Muscles | 1989 |
An endogenous Ca2+-sensitive proteinase converts the hepatic alpha 1-adrenergic receptor to guanine nucleotide-insensitive forms.
Topics: Adrenergic alpha-Antagonists; Age Factors; Animals; Calcium; Calpain; Cell Membrane; Egtazic Acid; Guanine Nucleotides; In Vitro Techniques; Liver; Male; Molecular Weight; Prazosin; Protease Inhibitors; Rats; Receptors, Adrenergic, alpha | 1986 |
The reversible activation by Mn2+ ions of the Ca2+-requiring neutral proteinase of human erythrocytes.
Topics: Calcium; Calpain; Drug Synergism; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Activation; Enzyme Precursors; Erythrocytes; Humans; Macromolecular Substances; Manganese; Molecular Weight | 1985 |
Degradation without apparent change in size of molybdate-stabilized nonactivated glucocorticoid-receptor complexes in rat thymus cytosol.
Topics: Animals; Calpain; Chromatography, Gel; Cytosol; Dexamethasone; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Male; Molecular Weight; Molybdenum; Protein Denaturation; Rats; Rats, Inbred Strains; Receptors, Glucocorticoid; Receptors, Steroid; Thymus Gland | 1985 |
[Calcium-activated neutral protease in the porcine skin].
Topics: Animals; Calpain; Egtazic Acid; Endopeptidases; Hydrogen-Ion Concentration; Protease Inhibitors; Skin; Swine | 1985 |
Activation of the PCSM-protein phosphatase by a Ca2+-dependent protease.
Topics: Animals; Calpain; Egtazic Acid; Enzyme Activation; Kinetics; Leupeptins; Muscles; Phosphoprotein Phosphatases; Rabbits | 1985 |
Role of Ca2+ and Ca2+-activated protease in myoblast fusion.
Topics: Animals; Calcimycin; Calcium; Calpain; Cell Fusion; Cells, Cultured; Egtazic Acid; Fibronectins; Fluorescent Antibody Technique; Mice; Muscles | 1986 |
Multiple calcium-activated neutral proteinases (CANP) in mouse retinal ganglion cell neurons: specificities for endogenous neuronal substrates and comparison to purified brain CANP.
Topics: Animals; Axons; Brain; Calcium; Calpain; Egtazic Acid; Female; Male; Mice; Mice, Inbred C57BL; Microscopy, Electron; Nerve Tissue Proteins; Neurons; Peptide Hydrolases; Retina; Retinal Ganglion Cells; Tissue Distribution; Visual Pathways | 1986 |
Effect of low calcium and protease inhibitors on synapse elimination during postnatal development in the rat soleus muscle.
Topics: Animals; Animals, Newborn; Calcium; Calpain; Egtazic Acid; Leupeptins; Mersalyl; Muscle Development; Neuromuscular Junction; Rats; Rats, Inbred Strains | 1986 |
Effects of low calcium and inhibition of calcium-activated neutral protease (CANP) on mature nerve terminal structure in the rat sternocostalis muscle.
Topics: Animals; Calcium; Calpain; Egtazic Acid; Leupeptins; Motor Neurons; Neuromuscular Junction; Neuronal Plasticity; Rats; Rats, Inbred Strains | 1987 |
Conversion of myelin-associated glycoprotein (MAG) to a smaller derivative by calcium activated neutral protease (CANP)-like enzyme in myelin and inhibition by E-64 analogue.
Topics: Calpain; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Humans; Immunosorbent Techniques; In Vitro Techniques; Leucine; Myelin Proteins; Myelin Sheath; Myelin-Associated Glycoprotein; Protease Inhibitors; Spectrophotometry, Atomic | 1984 |
Stringent requirement for Ca2+ in the removal of Z-lines and alpha-actinin from isolated myofibrils by Ca2+-activated neutral proteinase.
Topics: Actinin; Animals; Calcium; Calpain; Cations, Divalent; Egtazic Acid; Endopeptidases; Enzyme Activation; In Vitro Techniques; Membranes; Metals, Alkaline Earth; Microscopy, Interference; Microscopy, Phase-Contrast; Muscle Proteins; Myofibrils; Rabbits; Strontium | 1983 |
Aurintricarboxylic acid is an inhibitor of mu- and m-calpain.
Topics: Amino Acid Sequence; Animals; Apoptosis; Aurintricarboxylic Acid; Calpain; Caseins; Cathepsin B; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Kinetics; L-Lactate Dehydrogenase; Molecular Sequence Data; N-Methylaspartate; Neurons; Papain; Peptides; Rats; Spectrin | 1995 |
pp60src is an endogenous substrate for calpain in human blood platelets.
Topics: Antibodies, Monoclonal; Blood Platelets; Blotting, Western; Calcimycin; Calcium; Calpain; Dimethyl Sulfoxide; Dipeptides; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Microfilament Proteins; Molecular Weight; Platelet Aggregation; Proto-Oncogene Proteins pp60(c-src); Substrate Specificity; Talin | 1993 |
Proteolytic processing of Alzheimer's disease beta A4 amyloid precursor protein in human platelets.
Topics: Amyloid beta-Protein Precursor; Blood Platelets; Calcimycin; Calcium; Calpain; Cysteine Endopeptidases; Egtazic Acid; Humans; Peptide Fragments; Protease Inhibitors; Zinc | 1995 |
Selective release of a processed form of interleukin 1 alpha.
Topics: Calcimycin; Calcium; Calpain; Cell Line; Cysteine Proteinase Inhibitors; Egtazic Acid; Gene Expression; Humans; Interleukin-1; L-Lactate Dehydrogenase; Leucine; Methionine; Molecular Weight; Protein Processing, Post-Translational; Sulfur Radioisotopes; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1994 |
Microtubule-associated protein 2 as an early indicator of ischemia-induced neurodegeneration in the gerbil forebrain.
Topics: Animals; Calpain; Corpus Striatum; Dendrites; Egtazic Acid; Female; Fluorescent Antibody Technique; Gerbillinae; Hippocampus; Immunoenzyme Techniques; Ischemic Attack, Transient; Kinetics; Male; Microtubule-Associated Proteins; Nerve Degeneration; Neurons; Prosencephalon; Spectrin | 1994 |
Proteolytic cleavage of the integrin beta 4 subunit.
Topics: Antigens, Surface; Artifacts; Calcium; Calcium-Binding Proteins; Calpain; Cell Adhesion; Cell Survival; Digitonin; Egtazic Acid; Endopeptidases; Humans; Integrin alpha6beta4; Integrin beta4; Integrins; Ionomycin; Peptide Fragments; Tumor Cells, Cultured | 1994 |
Effects of phenelzine and hydralazine on hydrogen peroxide production and proteolysis in human red blood cells.
Topics: Blood Proteins; Blotting, Western; Calpain; Cells, Cultured; Chromatography, High Pressure Liquid; Egtazic Acid; Erythrocytes; Free Radical Scavengers; Humans; Hydralazine; Hydrogen Peroxide; Phenelzine; Reactive Oxygen Species; Stimulation, Chemical | 1993 |
Effect of high hydrostatic pressure on the conversion of alpha-connectin to beta-connectin.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calpain; Connectin; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Hydrostatic Pressure; Leucine; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Protein Kinases; Rabbits | 1993 |
Involvement of calcium-dependent cysteine protease in fibronectin-induced chemotactic migration of NIH-L13 fibroblasts.
Topics: 3T3 Cells; Animals; Calcium; Calpain; Chemotaxis; Egtazic Acid; Fibroblasts; Fibronectins; Kinetics; Mice; Protease Inhibitors | 1993 |
Binding and aggregation of human mu-calpain by terbium ion.
Topics: Binding Sites; Calcium; Calpain; Caseins; Dialysis; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Stability; Erythrocytes; Humans; Immunoblotting; Protein Binding; Terbium | 1996 |
Calpain secreted by activated human lymphoid cells degrades myelin.
Topics: Animals; Antibodies, Monoclonal; Calcimycin; Calcium; Calcium-Binding Proteins; Calpain; Chelating Agents; Culture Media, Conditioned; Demyelinating Diseases; Egtazic Acid; Humans; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, Large B-Cell, Diffuse; Monocytes; Myelin Basic Protein; Myelin Sheath; Neoplasm Proteins; Protease Inhibitors; Rabbits; Rats; T-Lymphocytes; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1995 |
The role of calpastatin (the specific calpain inhibitor) in myoblast differentiation and fusion.
Topics: Animals; Calcium-Binding Proteins; Calpain; Cell Differentiation; Cell Fusion; Cell Line; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Kinetics; Molecular Weight; Muscle Fibers, Skeletal; Rats | 1996 |
m-Calpain activation/depletion is associated with androgen-induced reduction of protein kinase C and proliferation of male accessory sex organ smooth muscle cells.
Topics: Androgens; Animals; Calpain; Cell Division; Egtazic Acid; Genitalia, Male; Guinea Pigs; Male; Octoxynol; Protein Kinase C; Seminal Vesicles | 1997 |
Inhibition of the growth of WI-38 fibroblasts by benzyloxycarbonyl-Leu-Leu-Tyr diazomethyl ketone: evidence that cleavage of p53 by a calpain-like protease is necessary for G1 to S-phase transition.
Topics: Calcium; Calpain; Cell Nucleus; Cysteine Proteinase Inhibitors; Diazomethane; Egtazic Acid; Fibroblasts; G1 Phase; Humans; Oligopeptides; Proto-Oncogene Proteins c-jun; S Phase; Tumor Suppressor Protein p53 | 1997 |
The N-terminal moiety of CDC25(Mm), a GDP/GTP exchange factor of Ras proteins, controls the activity of the catalytic domain. Modulation by calmodulin and calpain.
Topics: Animals; Calcium; Calmodulin; Calpain; Cell Cycle Proteins; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Mice; Phosphoprotein Phosphatases; ras-GRF1; Recombinant Proteins; Structure-Activity Relationship | 1997 |
Distinct substrate specificities and functional roles for the 78- and 76-kDa forms of mu-calpain in human platelets.
Topics: Antibodies; Blood Platelets; Calcimycin; Calpain; Cysteine Proteinase Inhibitors; Dimerization; Dipeptides; Egtazic Acid; Enzyme Activation; Enzyme Precursors; Humans; Kinetics; Macromolecular Substances; Molecular Weight; Organelles; Platelet Glycoprotein GPIIb-IIIa Complex; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins pp60(c-src); Subcellular Fractions; Substrate Specificity | 1997 |
Identification, characterization and partial purification of a thiol-protease which cleaves specifically the skeletal muscle ryanodine receptor/Ca2+ release channel.
Topics: Animals; Brain; Calpain; Chromatography, Affinity; Egtazic Acid; Lipid Bilayers; Membrane Potentials; Muscle Fibers, Fast-Twitch; Muscle, Skeletal; Myocardium; Rabbits; Ryanodine; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Substrate Specificity | 1998 |
The calpain-calpastatin system and protein degradation in fusing myoblasts.
Topics: Animals; Calcium; Calcium-Binding Proteins; Calpain; Cell Differentiation; Cell Division; Cell Fusion; Cell Line; Cysteine Proteinase Inhibitors; Egtazic Acid; Enzyme Activation; Muscle, Skeletal; Rats; Tropomyosin | 1998 |
Alterations of extracellular calcium elicit selective modes of cell death and protease activation in SH-SY5Y human neuroblastoma cells.
Topics: Calcium; Calpain; Caspase 3; Caspases; Cell Death; DNA, Neoplasm; Egtazic Acid; Endopeptidases; Enzyme Activation; Extracellular Space; Humans; L-Lactate Dehydrogenase; Necrosis; Neurons; Osmolar Concentration; Protease Inhibitors; Tumor Cells, Cultured | 1999 |
Possible mechanism for the decrease of mitochondrial aspartate aminotransferase activity in ischemic and hypoxic rat retinas.
Topics: Animals; Aspartate Aminotransferases; Calcium; Calpain; Cytosol; Egtazic Acid; Eye; Ischemia; Mitochondria; Protease Inhibitors; Rats; Retina; Ryanodine; Thapsigargin | 1999 |
Calcium-dependent cleavage of striatal enriched tyrosine phosphatase (STEP).
Topics: Animals; Calcimycin; Calcium; Calpain; Dipeptides; Egtazic Acid; Female; Glutamic Acid; Ionophores; Isoenzymes; Kinetics; Molecular Weight; Protein Tyrosine Phosphatases; Protein Tyrosine Phosphatases, Non-Receptor; Rats; Rats, Long-Evans; Thapsigargin; Transfection | 1999 |
Rapid increase in immunoreactivity to GFAP in astrocytes in vitro induced by acidic pH is mediated by calcium influx and calpain I.
Topics: Acids; Amino Acid Sequence; Animals; Antibodies; Astrocytes; Calcimycin; Calcium; Calcium Channel Blockers; Calpain; Carrier Proteins; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Diltiazem; Egtazic Acid; Enzyme Activation; Glial Fibrillary Acidic Protein; Glycoproteins; Hydrogen-Ion Concentration; In Vitro Techniques; Ionophores; Microfilament Proteins; Molecular Sequence Data; Nerve Tissue Proteins; Nifedipine; Prosencephalon; Rats; Rats, Inbred F344; Substrate Specificity; Verapamil | 2000 |
Neurotoxicity induces cleavage of p35 to p25 by calpain.
Topics: Alzheimer Disease; Amino Acid Sequence; Amyloid beta-Peptides; Animals; Calcium; Calpain; Cells, Cultured; Egtazic Acid; Glutamic Acid; Hydrogen Peroxide; Ionomycin; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Tissue Proteins; Neurons; Peptide Fragments; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Recombinant Proteins | 2000 |
Possible role of calpain in normal processing of beta-amyloid precursor protein in human platelets.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Blood Platelets; Calcimycin; Calcium; Calcium-Binding Proteins; Calpain; Cations, Divalent; Cell Extracts; Edetic Acid; Egtazic Acid; Endopeptidase K; Humans; Hydrogen-Ion Concentration; Inhibitory Concentration 50; Molecular Weight; Peptide Fragments; Protease Inhibitors; Protein Processing, Post-Translational; Trypsin | 2000 |
Pathogenesis of axonal degeneration: parallels between Wallerian degeneration and vincristine neuropathy.
Topics: Animals; Antineoplastic Agents, Phytogenic; Axons; Axotomy; Calpain; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Female; Ganglia, Spinal; Pregnancy; Rats; Rats, Sprague-Dawley; Vincristine; Wallerian Degeneration | 2000 |
Identification of an apoptotic cleavage product of BARD1 as an autoantigen: a potential factor in the antitumoral response mediated by apoptotic bodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Apoptosis; Autoantigens; Blotting, Western; BRCA1 Protein; Breast Neoplasms; Calpain; Carrier Proteins; Cell Cycle; Cell Fractionation; Cloning, Molecular; Colonic Neoplasms; Cysteine Proteinase Inhibitors; DNA, Complementary; Egtazic Acid; Enzyme Inhibitors; Gene Library; Humans; Leupeptins; Mammary Neoplasms, Animal; Mice; Molecular Sequence Data; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Tumor Cells, Cultured; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2000 |
Heterogeneous increases of cytoplasmic calcium: distinct effects on down-regulation of cell surface sodium channels and sodium channel subunit mRNA levels.
Topics: Animals; Binding, Competitive; Brefeldin A; Calcimycin; Calcium; Calcium-Binding Proteins; Calcium-Transporting ATPases; Calpain; Carbazoles; Cattle; Cells, Cultured; Chromaffin Cells; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Enzyme Inhibitors; Hydroquinones; Indoles; Ionophores; Marine Toxins; Oxocins; Protein Subunits; RNA, Messenger; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Saxitoxin; Scorpion Venoms; Sodium; Sodium Channels; Thapsigargin; Time Factors; Tritium; Veratridine | 2001 |
Site-specific calcium-dependent proteolysis of neuronal protein GAP-43.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; Calpain; Cell Compartmentation; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; GAP-43 Protein; Peptide Fragments; Peptide Hydrolases; Presynaptic Terminals; Rats; Signal Transduction; Synaptic Transmission; Synaptosomes | 2001 |
Crucial role of calpain in hypoxic PC12 cell death: calpain, but not caspases, mediates degradation of cytoskeletal proteins and protein kinase C-alpha and -delta.
Topics: Animals; Calcimycin; Calcium; Calpain; Caspases; Cell Death; Chelating Agents; Cysteine Proteinase Inhibitors; Cytoskeleton; Dipeptides; Egtazic Acid; Hypoxia-Ischemia, Brain; Ionophores; Isoenzymes; Nerve Degeneration; PC12 Cells; Peptide Hydrolases; Protein Kinase C; Protein Kinase C-alpha; Protein Kinase C-delta; Rats | 2001 |
Ethanol-induced apoptosis in hepatoma cells proceeds via intracellular Ca(2+) elevation, activation of TLCK-sensitive proteases, and cytochrome c release.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; Blotting, Western; Calcium; Calmodulin; Calpain; Carcinoma, Hepatocellular; Caspase 3; Caspase 9; Caspases; Cell Separation; Cytochrome c Group; Densitometry; Dose-Response Relationship, Drug; Egtazic Acid; Endopeptidases; Enzyme Activation; Ethanol; Fas Ligand Protein; fas Receptor; Flow Cytometry; Humans; Ions; Liver Neoplasms; Membrane Glycoproteins; Membrane Potentials; Mitochondria; Models, Biological; Proto-Oncogene Proteins c-bcl-2; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tosyllysine Chloromethyl Ketone; Transfection; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 2001 |
Phosphoinositide 3-kinase accelerates calpain-dependent proteolysis of fodrin during hypoxic cell death.
Topics: Acidosis; Animals; Antimetabolites; Buffers; Calcium; Calcium-Transporting ATPases; Calpain; Cell Death; Cell Hypoxia; Cell Survival; Cells, Cultured; Chelating Agents; Deoxyglucose; Dipeptides; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Gene Transfer Techniques; HEPES; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Sodium-Calcium Exchanger; Sodium-Hydrogen Exchangers | 2002 |
Effect of cold preservation on intracellular calcium concentration and calpain activity in rat sinusoidal endothelial cells.
Topics: Animals; Calcium; Calcium Channel Blockers; Calpain; Cathepsins; Cells, Cultured; Chelating Agents; Cryopreservation; Cysteine Endopeptidases; Dantrolene; Egtazic Acid; Endothelium, Vascular; Intracellular Membranes; Liver Circulation; Male; Multienzyme Complexes; Osmolar Concentration; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley | 2003 |
Lysophosphatidylcholine inhibits endothelial cell migration by increasing intracellular calcium and activating calpain.
Topics: Animals; Aorta; Calcimycin; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calpain; Cattle; Cell Movement; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Endothelium, Vascular; Enzyme Activation; Fluorescent Dyes; Fura-2; Ionophores; Lysophosphatidylcholines | 2003 |
Involvement of the ubiquitin-proteasome system in the early stages of wallerian degeneration.
Topics: Amino Acids; Animals; Animals, Newborn; Axons; Benzimidazoles; Blotting, Western; Calpain; Cells, Cultured; Chelating Agents; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytoskeleton; Disease Models, Animal; Drug Interactions; Egtazic Acid; Endopeptidases; Ganglia, Sympathetic; Immunohistochemistry; Leupeptins; Microtubules; Multienzyme Complexes; Nerve Growth Factor; Optic Nerve; Optic Nerve Injuries; Peptide Fragments; Proteasome Endopeptidase Complex; Rats; Time Factors; Tubulin; Ubiquitin; Wallerian Degeneration | 2003 |
Cys32 and His105 are the critical residues for the calcium-dependent cysteine proteolytic activity of CvaB, an ATP-binding cassette transporter.
Topics: Amino Acid Sequence; Animals; ATP-Binding Cassette Transporters; Blotting, Western; Calcium; Calpain; Cell Division; Colicins; Culture Media; Cysteine; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Escherichia coli Proteins; Ethylmaleimide; Histidine; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Peptides; Plasmids; Protease Inhibitors; Protein Binding; Protein Structure, Tertiary; Rats; Sequence Homology, Amino Acid; Time Factors | 2004 |
Stimulation of beta-amyloid precursor protein alpha-processing by phorbol ester involves calcium and calpain activation.
Topics: Amyloid beta-Protein Precursor; Calcium; Calpain; Cells, Cultured; Chelating Agents; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Fibronectins; Humans; Microtubule-Associated Proteins; Peptide Fragments; Phorbol 12,13-Dibutyrate; tau Proteins | 2004 |
Signal transduction of p53-independent apoptotic pathway induced by hexavalent chromium in U937 cells.
Topics: Apoptosis; Blotting, Western; Calcium Signaling; Calpain; Cell Cycle; Chelating Agents; Chromium; DNA Fragmentation; Egtazic Acid; fas Receptor; Free Radicals; Genes, p53; Humans; JNK Mitogen-Activated Protein Kinases; Lipid Peroxidation; MAP Kinase Kinase 4; Mitochondria; Mitogen-Activated Protein Kinase Kinases; Signal Transduction; U937 Cells | 2004 |
Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus.
Topics: Calcium-Binding Proteins; Calpain; Cell Line, Tumor; Centrifugation, Density Gradient; Chelating Agents; Cytoplasm; Cytosol; Deoxycholic Acid; Detergents; Edetic Acid; Egtazic Acid; Endopeptidase K; Endoplasmic Reticulum; Golgi Apparatus; Humans; Microscopy, Confocal; Microscopy, Fluorescence; Microsomes; Models, Biological; Potassium Chloride; Protein Isoforms; Sodium Chloride; Static Electricity; Time Factors; Ubiquitin | 2004 |
Interferon-inducible protein 9 (CXCL11)-induced cell motility in keratinocytes requires calcium flux-dependent activation of mu-calpain.
Topics: Calcium; Calpain; Cell Line; Cell Movement; Chelating Agents; Chemokine CXCL11; Chemokines, CXC; Down-Regulation; Egtazic Acid; Epidermal Growth Factor; Extracellular Signal-Regulated MAP Kinases; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; Humans; Interferons; Keratinocytes; Protein-Tyrosine Kinases; RNA, Small Interfering; Vinculin | 2005 |
EP1 receptor-mediated migration of the first trimester human extravillous trophoblast: the role of intracellular calcium and calpain.
Topics: Calcium; Calcium Signaling; Calpain; Cell Movement; Cells, Cultured; Chelating Agents; Chorionic Villi; Dinoprostone; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Female; Humans; Phenotype; Pregnancy; Pregnancy Trimester, First; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Reverse Transcriptase Polymerase Chain Reaction; Thapsigargin; Trophoblasts; Type C Phospholipases | 2005 |
Involvement of intracellular Ca2+ levels in nonsteroidal anti-inflammatory drug-induced apoptosis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; Biological Transport; Calcium; Calpain; CCAAT-Enhancer-Binding Proteins; Celecoxib; Cell Membrane Permeability; Cells, Cultured; Chelating Agents; Egtazic Acid; Gastric Mucosa; Guinea Pigs; Liposomes; Membrane Potentials; Mitochondria; Potassium; Pyrazoles; Sulfonamides; Transcription Factor CHOP; Transcription Factors | 2005 |
Apoptosis is secondary to non-apoptotic axonal degeneration in neurons exposed to Abeta in distal axons.
Topics: Amyloid beta-Peptides; Animals; Animals, Newborn; Antidotes; Apoptosis; Axons; Blotting, Western; Calcium-Binding Proteins; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Interactions; Egtazic Acid; Nerve Degeneration; Nerve Growth Factor; Neurons; Peptide Fragments; Prosencephalon; Rats; Rats, Sprague-Dawley; Superior Cervical Ganglion; Tetrazolium Salts; Thiazoles | 2006 |
Degraded collagen induces calpain-mediated apoptosis and destruction of the X-chromosome-linked inhibitor of apoptosis (xIAP) in human vascular smooth muscle cells.
Topics: Apoptosis; Atherosclerosis; Calpain; Caspases; Cells, Cultured; Collagen; Collagenases; Dipeptides; Egtazic Acid; Enzyme Inhibitors; Extracellular Matrix; Gels; Humans; Microscopy, Fluorescence; Muscle, Smooth, Vascular; Polymers; Recombinant Proteins; X-Linked Inhibitor of Apoptosis Protein | 2006 |
Clofibrate-induced apoptosis is mediated by Ca2+-dependent caspase-12 activation.
Topics: Animals; Apoptosis; Calcium; Calpain; Caspase 12; Caspase 3; Caspase 9; Caspases; Cells, Cultured; Chelating Agents; Clofibrate; Cytosol; Egtazic Acid; Enzyme Activation; Hypolipidemic Agents; Muscle, Skeletal; Rats | 2006 |
Degradation of human aquaporin 0 by m-calpain.
Topics: Amino Acid Sequence; Aquaporins; Calcium; Calpain; Chelating Agents; Chromatography, High Pressure Liquid; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Eye Proteins; Humans; Hydrolysis; Infant, Newborn; Lens, Crystalline; Membrane Glycoproteins; Molecular Sequence Data; Protein Isoforms; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2005 |
Endoplasmic reticulum Ca2+ depletion induces endothelial cell apoptosis independently of caspase-12.
Topics: Amino Acid Chloromethyl Ketones; Animals; Aorta; Apoptosis; Blotting, Western; Bradykinin; Calcium; Calcium-Transporting ATPases; Calpain; Caspase 12; Caspase Inhibitors; Caspases; Cells, Cultured; Chelating Agents; Cytosol; Dipeptides; DNA Fragmentation; Egtazic Acid; Endoplasmic Reticulum; Endothelial Cells; Endothelium, Vascular; Enzyme Inhibitors; Signal Transduction; Swine; Thapsigargin | 2006 |
Tributyltin-induced cell death is mediated by calpain in PC12 cells.
Topics: Analysis of Variance; Animals; Calcium; Calpain; Caspase 3; Caspases; Cell Death; Cell Survival; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Fura-2; L-Lactate Dehydrogenase; PC12 Cells; Rats; Time Factors; Trialkyltin Compounds; Water Pollutants | 2006 |
beta-Amyloid-induced dynamin 1 degradation is mediated by N-methyl-D-aspartate receptors in hippocampal neurons.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Calcium; Calcium Channels, L-Type; Calpain; Cells, Cultured; Dynamin I; Egtazic Acid; Enzyme Activation; Hippocampus; Homeostasis; Rats; Receptors, N-Methyl-D-Aspartate; Synapses | 2006 |
Involvement of calcium-mediated apoptotic signals in H2O2-induced MIN6N8a cell death.
Topics: Animals; Apoptosis; Calcineurin; Calcineurin Inhibitors; Calcium; Calpain; Caspase 3; Cell Line, Tumor; Cell Survival; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Hydrogen Peroxide; Insulinoma; Intracellular Fluid; JNK Mitogen-Activated Protein Kinases; Macrocyclic Compounds; Oxazoles; Oxidants; Poly(ADP-ribose) Polymerases; Ryanodine; Signal Transduction | 2006 |
Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of beta-lapachone on endothelial cells in vitro.
Topics: Angiogenesis Inhibitors; Apoptosis; Arginine; Calcium; Calpain; Caspases; Cell Line; Cell Survival; Chelating Agents; Cyclic GMP; Dose-Response Relationship, Drug; Egtazic Acid; Endothelial Cells; Enzyme Activation; Enzyme Inhibitors; Humans; Leupeptins; Membrane Potential, Mitochondrial; Naphthoquinones; Neovascularization, Physiologic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Donors; Nitric Oxide Synthase Type III; Oligopeptides; Signal Transduction; Time Factors | 2007 |
Characterization of the intracellular proteolytic cleavage of myocilin and identification of calpain II as a myocilin-processing protease.
Topics: Calcium-Binding Proteins; Calpain; Cell Line; Cytoskeletal Proteins; Dipeptides; Egtazic Acid; Endopeptidase K; Eye Proteins; Glaucoma; Glycoproteins; Humans; Ionomycin; Mutation, Missense; Protein Conformation; Protein Structure, Tertiary; Transfection | 2007 |
Oxidative stress and calpain inhibition induce alpha B-crystallin phosphorylation via p38-MAPK and calcium signalling pathways in H9c2 cells.
Topics: alpha-Crystallin B Chain; Animals; Apoptosis; Calcium Signaling; Calpain; Caspase 3; Cell Line; Cell Nucleus; Cytochromes c; Egtazic Acid; Hydrogen Peroxide; Leupeptins; Myocytes, Cardiac; Oligopeptides; Oxidative Stress; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Phosphoserine; Poly(ADP-ribose) Polymerases; Protein Transport; Rats; Ribosomal Protein S6 Kinases, 90-kDa; Time Factors; Tubulin | 2008 |
Identification of small molecule inhibitors of beta-amyloid cytotoxicity through a cell-based high-throughput screening platform.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Calcium; Calpain; Cell Death; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Egtazic Acid; Humans; Luminescence; Mass Screening; Neurodegenerative Diseases; Time Factors | 2008 |
Wnt5A activates the calpain-mediated cleavage of filamin A.
Topics: Calpain; Cell Line, Tumor; Cell Movement; Chelating Agents; Contractile Proteins; Cytoskeleton; Egtazic Acid; Filamins; Gene Expression Regulation, Neoplastic; Humans; Melanoma; Microfilament Proteins; Proto-Oncogene Proteins; Receptor Tyrosine Kinase-like Orphan Receptors; Receptors, Cell Surface; RNA, Small Interfering; Skin Neoplasms; Wnt Proteins; Wnt-5a Protein | 2009 |
Na+/H+ exchanger mediates TNF-alpha-induced hepatocyte apoptosis via the calpain-dependent degradation of Bcl-xL.
Topics: Apoptosis; bcl-2-Associated X Protein; bcl-X Protein; Calcium; Calpain; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Dose-Response Relationship, Drug; Egtazic Acid; Guanidines; Hepatocytes; Humans; Signal Transduction; Sodium-Hydrogen Exchangers; Sulfones; Time Factors; Tumor Necrosis Factor-alpha | 2009 |
Determining time of death: temperature-dependent postmortem changes in calcineurin A, MARCKS, CaMKII, and protein phosphatase 2A in mouse.
Topics: Animals; Blotting, Western; Calcineurin; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calpain; Centrifugation; Cysteine Proteinase Inhibitors; Egtazic Acid; Enzyme Inhibitors; Forensic Pathology; Imidazoles; Intracellular Signaling Peptides and Proteins; Leupeptins; Lung; Membrane Proteins; Mice; Muscle, Skeletal; Myristoylated Alanine-Rich C Kinase Substrate; Postmortem Changes; Proteasome Endopeptidase Complex; Protein Phosphatase 2; Temperature | 2009 |
Calcium-dependent cleavage of the Na(+)/Ca(2+) exchanger by m-calpain in isolated endoplasmic reticulum.
Topics: Animals; Blotting, Western; Calcium; Calcium-Binding Proteins; Calpain; Cattle; Dipeptides; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endoplasmic Reticulum; Immunoprecipitation; In Vitro Techniques; Muscle, Smooth; Protein Binding; Pulmonary Artery; Sodium-Calcium Exchanger | 2010 |
Caspase-4 is partially cleaved by calpain via the impairment of Ca2+ homeostasis under the ER stress.
Topics: Calcium; Calpain; Caspases, Initiator; Cell Line, Tumor; Chelating Agents; Egtazic Acid; Endoplasmic Reticulum; Enzyme Activation; Enzyme Inhibitors; Homeostasis; Humans; Hydrolysis; Thapsigargin; Tunicamycin | 2010 |
Brain-derived neurotrophic factor and epidermal growth factor activate neuronal m-calpain via mitogen-activated protein kinase-dependent phosphorylation.
Topics: Actins; Analysis of Variance; Animals; Axons; Brain-Derived Neurotrophic Factor; Calcium; Calpain; Cells, Cultured; Chelating Agents; Dendritic Spines; Drug Interactions; Egtazic Acid; Embryo, Mammalian; Enzyme Inhibitors; Epidermal Growth Factor; Fluorescence Resonance Energy Transfer; Hippocampus; Humans; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases; Naphthalenesulfonates; Neocortex; Neurons; p-Dimethylaminoazobenzene; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptor, trkB; RNA, Small Interfering; Transfection | 2010 |
A novel Ca2+-activated protease from germinating Vigna radiata seeds and its role in storage protein mobilization.
Topics: Calmodulin; Calpain; Chlorpromazine; Edetic Acid; Egtazic Acid; Enzyme Activation; Fabaceae; Germination; Leucine; Mercaptoethanol; Plant Proteins; Seeds; Serine Proteinase Inhibitors | 2010 |
An apoptosis targeted stimulus with nanosecond pulsed electric fields (nsPEFs) in E4 squamous cell carcinoma.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Calpain; Carcinoma, Squamous Cell; Caspases; Cell Line, Tumor; Cell Membrane; Cytochromes c; Egtazic Acid; Electric Stimulation; Electricity; Enzyme Activation; Humans; Membrane Potential, Mitochondrial; Protease Inhibitors; Reactive Oxygen Species; Time Factors | 2011 |
Mechanism of pyrethroid pesticide-induced apoptosis: role of calpain and the ER stress pathway.
Topics: Apoptosis; Calcium; Calpain; Caspase 12; Caspase 3; Caspase 9; Cell Line; Cytochromes c; DNA Fragmentation; Egtazic Acid; Endoplasmic Reticulum; Humans; Mitochondria; Nitriles; Pesticides; Pyrethrins; RNA, Small Interfering; Signal Transduction; Unfolded Protein Response | 2011 |
17beta-estradiol induces both up-regulation and processing of cyclin E in a calpain-dependent manner in MCF-7 breast cancer cells.
Topics: Breast Neoplasms; Butadienes; Calcium; Calpain; Cell Line, Tumor; Chelating Agents; Cyclin E; Egtazic Acid; Estradiol; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Nitriles; Signal Transduction; Up-Regulation | 2012 |
A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death.
Topics: Amyloid beta-Peptides; Animals; Calcium; Calcium Channel Blockers; Calpain; Caspase 3; Cell Death; Cell Differentiation; Cells, Cultured; Chelating Agents; Cricetinae; Dogs; Dose-Response Relationship, Drug; Egtazic Acid; Embryo, Mammalian; Endoplasmic Reticulum; Enzyme Activation; Female; Hippocampus; Male; Mice; Mice, Knockout; Nerve Growth Factor; Neurons; Patch-Clamp Techniques; Peptide Fragments; Proteolysis; Rats; RNA Interference; Sodium; Sodium-Calcium Exchanger; Time Factors; Transfection; Up-Regulation | 2012 |
High-energy compounds mobilize intracellular Ca2+ and activate calpain in cultured cells: is calpain an energy-dependent protease?
Topics: Acetyl Coenzyme A; Adenosine Triphosphate; Alzheimer Disease; Calcium; Calpain; Cell Line, Tumor; Chelating Agents; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Extracellular Space; Glutamic Acid; Humans; Intracellular Space; Nicotine; Nicotinic Agonists; Phosphocreatine; Phosphoenolpyruvate; Rotenone; Uncoupling Agents | 2014 |
Hyperthermia induces apoptosis through endoplasmic reticulum and reactive oxygen species in human osteosarcoma cells.
Topics: Apoptosis; bcl-2 Homologous Antagonist-Killer Protein; bcl-2-Associated X Protein; bcl-X Protein; Calpain; Caspase 3; Cell Line, Tumor; Cytochromes c; Down-Regulation; Egtazic Acid; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Humans; Mitochondria; Osteosarcoma; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; RNA, Small Interfering; Temperature; Up-Regulation | 2014 |