egtazic acid has been researched along with 1-(5-isoquinolinesulfonyl)-2-methylpiperazine in 86 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (8.14) | 18.7374 |
| 1990's | 53 (61.63) | 18.2507 |
| 2000's | 23 (26.74) | 29.6817 |
| 2010's | 3 (3.49) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hemmings, BA; Monard, D; Stone, SR; Suidan, HS | 1 |
| Koide, Y; Miyachi, H; Sekiguchi, S; Shibata, T; Takemura, Y; Tukemura, Y | 1 |
| Frangos, JA; Hsieh, HJ; Li, NQ | 1 |
| Citi, S | 1 |
| Kawase, T; Van Breemen, C | 1 |
| Nakamura, T; Nozawa, Y; Osada, S; Saji, S | 1 |
| Kennedy, MB; Molloy, SS | 1 |
| Kennedy, MS; Maddon, PJ; McDougal, JS; Orloff, GM; Orloff, SL | 1 |
| Chiou, S; Davis, JS; Fineberg, NS; Ganguly, A | 1 |
| Decker, K; Schulze-Specking, A; Weinhold, L | 1 |
| Huang, CK; Laramee, GR | 1 |
| Fu, T; Nozawa, Y; Okano, Y | 1 |
| Chang, JP; de Leeuw, R; Jobin, RM | 1 |
| Eguchi, S; Emori, T; Hirata, Y; Imai, T; Kanno, K; Marumo, F; Ohta, K; Shichiri, M | 1 |
| Huang, CK; Laramee, GR; Sha'afi, RI; Yamazaki, M | 1 |
| Hawgood, BJ; Rodrigues-Simioni, L; Smith, IC | 1 |
| Bement, WM; Capco, DG | 1 |
| Bigby, M; Fierro, JF; Sy, MS; Wang, P | 1 |
| Aoki, Y; Matsumura, K; Sato, K; Shimada, M | 1 |
| Iwata, K; Sasaki, Y | 1 |
| Djeu, JY; Richards, AL | 1 |
| Chan, SO; Wong, SS; Yeung, DC | 1 |
| Abe, S; Hirano, K; Kai, H; Kanaide, H; Kodama, M; Nakamura, M | 1 |
| Lichtman, MA; Segel, GB; Woodlock, TJ | 1 |
| Christiansen, NO; Larsen, CS | 1 |
| Agapito, MT; Garcia-Herrero, I; Recio, JM; Rodriguez-Cabello, JC | 1 |
| Badwey, JA; Heyworth, PG; Horn, W; Karnovsky, ML; Robinson, JM | 1 |
| Gavioli, R; Giuliani, AL; Spisani, S; Traniello, S | 1 |
| Bazan, HE; Dobard, P; Reddy, ST | 1 |
| Fan, P | 1 |
| Huang, CK; Liang, L | 1 |
| Bertrand, R; Jenkins, J; Pommier, Y; Solary, E | 1 |
| Cheng, H; Lakatta, EG; Lederer, WJ; Suzuki, T; Xiao, RP | 1 |
| Kamm, KE; Luby-Phelps, K; Stull, JT; Tansey, MG | 1 |
| Amino, K; Fujimoto, T; Honda, Y; Takahashi, M | 1 |
| Ericson, LE; Fagman, H; Nilsson, M | 1 |
| McCullough, LA; Westfall, TC | 1 |
| Artemenko, IP; Hokin, LE; Los, GV | 1 |
| Bevan, S; Boddeke, HW; Docherty, RJ; Yeats, JC | 1 |
| Bilski, JJ; Grazul-Bilska, AT; Kirsch, JD; Redmer, DA; Reynolds, LP | 1 |
| Imada-Shirakata, Y; Kotera, T; Okuma, M; Ueda, S | 1 |
| Fabiani, R; Marchetti, C; Mastrandrea, V; Migliorati, G; Moraca, R; Morozzi, G; Nicoletti, I; Riccardi, C | 1 |
| Babich, M; Foti, LR; Mathias, KL | 1 |
| Atsumi, T; Hosoi, K; Kurihara, K; Shioda, Y; Sugita, K; Ueha, T | 1 |
| Shimizu, T | 1 |
| Kwak, SH; Lee, SH | 1 |
| Reinach, PS; Torres-zamorano, V; Wu, X; Yang, H | 1 |
| Behar, J; Biancani, P; Chen, Q; Harnett, K; Xiao, Z; Yu, P | 1 |
| Dubyak, GR; Ganapathi, R; Grabowski, DR; Hidaka, H; Rybicki, L | 1 |
| Coleman, R; Roma, MG; Shaw, R; Stone, V | 1 |
| Kada, K; Kamiya, K; Kodama, I; Naruse, K; Toyama, J; Yasui, K | 1 |
| Kobayashi, K; Manabe, T; Takahashi, T | 1 |
| Ito, M; Nakano, T; Narumiya, S; Nishikawa, M; Sasaki, Y; Shiku, H; Suzuki, Y; Wada, H; Yamamoto, M | 1 |
| Isohama, Y; Kai, H; Miyata, T; Okumura, M; Shinozawa, S | 1 |
| Chen, J; Hoffman, BB; Hu, ZW; Lin, R | 1 |
| Chen, YZ; Xing, BR; Zhu, BG | 1 |
| Edsall, L; Kazlauskas, A; Olivera, A; Poulton, S; Spiegel, S | 1 |
| Daniel, JL; Kunapuli, SP; Paul, BZ | 1 |
| Jope, RS; Pacheco, MA | 1 |
| Ahmed-Choudhury, J; Coleman, R; Roma, MG | 1 |
| Dong, XP; Wang, DS; Xu, TL | 1 |
| Bhattacharya, A; Chandok, MR; Deswal, R; Pandey, GK; Sopory, SK; Yadav, N | 1 |
| Tse, A; Tse, FW | 1 |
| Dietz, R; Gschwend, S; Orzechowski, HD; Paul, M; Stula, M; Vetter, R; von Harsdorf, R | 1 |
| Boland, R; Buitrago, C; de Boland, AR; Morelli, S | 1 |
| Miyata, Y; Nagano, M; Sato, S; Ui-Tei, K | 1 |
| Alpini, G; Baiocchi, L; Chowdhury, U; Francis, H; Glaser, S; Kanno, N; LeSage, G; Phinizy, JL | 1 |
| Akopian, A; Witkovsky, P | 1 |
| Nakajima, Y; Nakanishi, S; Shinohara, Y | 1 |
| Di Virgilio, F; Dichmann, S; Ferrari, D; Herouy, Y; Idzko, M; Luttmann, W; Norgauer, J; Panther, E; Virchow , C | 1 |
| Bilski, JJ; Grazul-Bilska, AT; Redmer, DA; Reynolds, LP | 1 |
| Coleman, R; Elias, E; Milkiewicz, P; Roma, MG | 1 |
| Hörsch, D; Trümper, A; Trümper, K | 1 |
| Alpini, G; Alvaro, D; Benedetti, A; Francis, H; Glaser, SS; Lesage, GD; Marucci, L; Marzioni, M; Patel, T; Phinizy, JL | 1 |
| Alpini, G; Alvaro, D; Barbaro, B; Francis, H; Glaser, S; LeSage, G; Mancino, MG; Marzioni, M; Mauldin, J; Phinizy, JL; Rashid, S; Roskams, T; Stoica, G; Ueno, Y | 1 |
| Fukushi, H; Morishima, Y; Shirasaki, Y; Takano, H | 1 |
| Bigdai, EV; Samoilov, VO | 1 |
| Jiao, S; Liu, LY; Ma, LJ; Mei, YA; Wei, SM | 1 |
| Jiang, L; Kang, J; Kang, N; Nedergaard, M; Xu, J | 1 |
| Cameron, P; Kanke, T; Macfarlane, SR; McKenzie, RC; Plevin, R; Sloss, CM | 1 |
| Amobi, NI; Chung, IP; Smith, IC | 1 |
| Hung, AY; Magoski, NS | 1 |
| Arredondo, J; Chernyavsky, AI; Grando, SA; Jolkovsky, DL; Pinkerton, KE | 1 |
| Blanco, CE; Villamor, E; Zoer, B | 1 |
| Greenwood, JA; Ma, L; Schachner, M | 1 |
| Bai, W; Cui, C; Yang, J; Zeng, X | 1 |
86 other study(ies) available for egtazic acid and 1-(5-isoquinolinesulfonyl)-2-methylpiperazine
| Article | Year |
|---|---|
Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcimycin; Cyclic AMP; Egtazic Acid; Isoquinolines; Mice; Neurites; Neuroblastoma; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Cell Surface; Receptors, Thrombin; Staurosporine; Thrombin; Transcription, Genetic; Tumor Cells, Cultured | 1992 |
Effect of verapamil on the class I major histocompatibility complex antigen expression in K562 chronic myelogenous leukemia cells treated with recombinant human interferon-gamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Blotting, Northern; Calcimycin; Calmodulin; Cell Line; Egtazic Acid; Genes, MHC Class I; Genes, myc; Histocompatibility Antigens Class I; Humans; Interferon-gamma; Isoquinolines; Kinetics; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Piperazines; Protein Kinase Inhibitors; Recombinant Proteins; RNA, Neoplasm; Signal Transduction; Sulfonamides; Tumor Necrosis Factor-alpha; Verapamil | 1992 |
Shear-induced platelet-derived growth factor gene expression in human endothelial cells is mediated by protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Cells, Cultured; Egtazic Acid; Endothelium, Vascular; Gene Expression Regulation; Guanosine Diphosphate; Humans; Ibuprofen; Indomethacin; Isoquinolines; Neomycin; Piperazines; Platelet-Derived Growth Factor; Protein Kinase C; RNA, Messenger; Signal Transduction; Staurosporine; Stress, Mechanical; Sulfonamides; Transcriptional Activation | 1992 |
Protein kinase inhibitors prevent junction dissociation induced by low extracellular calcium in MDCK epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Azepines; Calcium; Cell Communication; Cell Line; Dogs; Egtazic Acid; Epithelium; Fluorescent Antibody Technique; Intercellular Junctions; Isoquinolines; Kidney; Kinetics; Naphthalenes; Piperazines; Protein Kinase Inhibitors; Staurosporine; Sulfonamides | 1992 |
Aluminum fluoride induces a reversible Ca2+ sensitization in alpha-toxin-permeabilized vascular smooth muscle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum; Aluminum Compounds; Animals; Bacterial Toxins; Calcium; Egtazic Acid; Fluorides; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Hemolysin Proteins; In Vitro Techniques; Isoquinolines; Muscle, Smooth, Vascular; Piperazines; Rabbits; Vasoconstriction | 1992 |
Cytosolic calcium oscillations induced by hepatocyte growth factor (HGF) in single fura-2-loaded cultured hepatocytes: effects of extracellular calcium and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bilirubin; Calcium; Cells, Cultured; Cytosol; Egtazic Acid; Fura-2; Isoquinolines; Piperazines; Protein Kinase C; Rats; Serum Albumin; Serum Albumin, Human; Terpenes; Thapsigargin | 1992 |
Autophosphorylation of type II Ca2+/calmodulin-dependent protein kinase in cultures of postnatal rat hippocampal slices.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aging; Animals; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Egtazic Acid; Hippocampus; Isoquinolines; Kinetics; Organ Culture Techniques; Organ Specificity; Phosphopeptides; Phosphorylation; Piperazines; Protein Kinases; Rats; Rats, Inbred Strains | 1991 |
Penetration of CD4 T cells by HIV-1. The CD4 receptor does not internalize with HIV, and CD4-related signal transduction events are not required for entry.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium Channel Blockers; Calmodulin; CD4 Antigens; CD4-Positive T-Lymphocytes; Cells, Cultured; Cyclosporins; Cytochalasins; Egtazic Acid; HIV-1; Humans; In Vitro Techniques; Isoquinolines; Lymphocyte Activation; Nerve Tissue Proteins; Pertussis Toxin; Piperazines; Polymerase Chain Reaction; Protein Kinase C; Signal Transduction; Sulfonamides; Tetradecanoylphorbol Acetate; Virulence Factors, Bordetella | 1991 |
Greater importance of Ca(2+)-calmodulin in maintenance of ang II- and K(+)-mediated aldosterone secretion: lesser role of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aldosterone; Angiotensin II; Animals; Calcium; Calmodulin; Cattle; Diglycerides; Dose-Response Relationship, Drug; Egtazic Acid; Imidazoles; In Vitro Techniques; Isoquinolines; Kinetics; Nitrendipine; Piperazines; Potassium; Protein Kinase C; Sulfonamides; Tetradecanoylphorbol Acetate; Zona Glomerulosa | 1992 |
Signal transduction in endotoxin-stimulated synthesis of TNF-alpha and prostaglandin E2 by rat Kupffer cells. Role of extracellular calcium ions and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Dinoprostone; Egtazic Acid; Endotoxins; Interferon-gamma; Isoquinolines; Kinetics; Kupffer Cells; Lipopolysaccharides; Male; Piperazines; Protein Kinase C; Rats; Rats, Inbred Strains; Recombinant Proteins; Salmonella; Staurosporine; Tetradecanoylphorbol Acetate; Tumor Necrosis Factor-alpha; Zymosan | 1991 |
Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: effect of leukotriene B4 and cytochalasin B.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cytochalasin B; Detergents; Egtazic Acid; Enzyme Activation; Histones; In Vitro Techniques; Isoquinolines; Kinetics; Leukotriene B4; Neutrophils; Octoxynol; Phosphorylation; Piperazines; Polyethylene Glycols; Protamine Kinase; Rabbits; Vanadates | 1991 |
Calcium oscillation induced by bradykinin in polyoma middle T antigen-transformed NIH3T3 fibroblasts: evidence for dependence on protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antigens, Polyomavirus Transforming; Bradykinin; Cadmium; Cadmium Chloride; Calcium; Cell Line, Transformed; Egtazic Acid; Fibroblasts; Fura-2; Imidazoles; Isoquinolines; Mice; Mice, Inbred Strains; Oscillometry; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate | 1991 |
Possible involvement of protein kinase C in gonadotropin and growth hormone release from dispersed goldfish pituitary cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Diglycerides; Egtazic Acid; Enzyme Activation; Goldfish; Gonadotropin-Releasing Hormone; Gonadotropins, Pituitary; Growth Hormone; Isoquinolines; Phorbol 12,13-Dibutyrate; Phorbol Esters; Piperazines; Pituitary Gland; Protein Kinase C; Tetradecanoylphorbol Acetate; Verapamil | 1991 |
Cellular mechanism of endothelin-1 release by angiotensin and vasopressin.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Angiotensin II; Animals; Arginine Vasopressin; Calcium; Cattle; Cells, Cultured; Diglycerides; Dose-Response Relationship, Drug; Down-Regulation; Egtazic Acid; Endothelins; Endothelium, Vascular; In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoquinolines; Neomycin; Nicardipine; Piperazines; Protein Kinase C; Protein Kinase Inhibitors; Staurosporine | 1991 |
Stimulation of a histone H4 protein kinase in Triton X-100 lysates of rabbit peritoneal neutrophils pretreated with chemotactic factors: lack of requirements of calcium mobilization and protein kinase C activation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cells, Cultured; Detergents; Egtazic Acid; Enzyme Activation; Isoquinolines; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Octoxynol; Peritoneal Cavity; Piperazines; Polyethylene Glycols; Protamine Kinase; Protein Kinase C; Rabbits; Signal Transduction; Tetradecanoylphorbol Acetate | 1990 |
Properties of the early phases of crotoxin poisoning at frog neuromuscular junctions.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Chelating Agents; Crotoxin; Egtazic Acid; Evoked Potentials; Isoquinolines; Motor Endplate; Neuromuscular Junction; Piperazines; Protein Kinase C; Rana temporaria | 1990 |
Protein kinase C acts downstream of calcium at entry into the first mitotic interphase of Xenopus laevis.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Egtazic Acid; Exocytosis; Interphase; Isoquinolines; Oocytes; Piperazines; Protein Kinase C; Signal Transduction; Sphingosine; Sulfonamides; Tetradecanoylphorbol Acetate; Xenopus laevis | 1990 |
Phorbol myristate acetate-induced down-modulation of CD4 is dependent on calmodulin and intracellular calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium; Calmodulin; CD4 Antigens; Cytochalasin B; Cytoplasm; Demecolcine; Down-Regulation; Egtazic Acid; Isoquinolines; Mice; Mice, Inbred BALB C; Phosphorylation; Piperazines; Protein Kinase C; Tetradecanoylphorbol Acetate; Tubulin | 1990 |
Praziquantel-induced secretion of proteolytic enzyme from Schistosoma mansoni cercariae.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Induction; Isoquinolines; Peptide Hydrolases; Piperazines; Praziquantel; Schistosoma mansoni; Sulfonamides; Verapamil | 1990 |
Concanavalin A- and fetal-calf-serum-induced rounding and myosin light chain phosphorylation in cultured smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aorta; Blood; Calcimycin; Calcium; Cells, Cultured; Chickens; Concanavalin A; Culture Media; Cytochalasin B; Cytochalasins; Diltiazem; Egtazic Acid; Gizzard, Avian; Ionomycin; Isoquinolines; Kinetics; Muscle, Smooth; Muscle, Smooth, Vascular; Myosin Subfragments; Phosphorylation; Rabbits; Verapamil | 1990 |
Calcium-dependent natural killer and calcium-independent natural cytotoxic activities in an IL-2-dependent killer cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calmodulin; Cell Line; Cytotoxicity, Immunologic; Egtazic Acid; Gallic Acid; Immunity, Cellular; Isoquinolines; Killer Cells, Natural; Mice; Piperazines; Protein Kinase C; Sulfonamides; Verapamil | 1990 |
Regulation of Ki-ras expression in Reuber H35 cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Bucladesine; Calcimycin; Calcium; Cell Line; Diglycerides; DNA Probes; Egtazic Acid; Gene Expression Regulation, Neoplastic; Genes, ras; Glucagon; Isoquinolines; Kinetics; Liver Neoplasms, Experimental; Piperazines; Protein Kinase Inhibitors; Rats; RNA, Neoplasm; Tetradecanoylphorbol Acetate; Verapamil | 1990 |
Endothelin-induced Ca-independent contraction of the porcine coronary artery.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Caffeine; Calcium; Coronary Vessels; Dose-Response Relationship, Drug; Egtazic Acid; Endothelins; Endothelium, Vascular; Histamine; Isoquinolines; Kinetics; Muscle Contraction; Peptides; Piperazines; Protein Kinase C; Spectrometry, Fluorescence; Swine | 1989 |
Diacylglycerol and calcium induce rapid enhancement of A-system amino acid transport by independent mechanisms in human T-lymphocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acids; Biological Transport; Calcium; Cycloheximide; Cytoplasm; Diglycerides; Egtazic Acid; Ethers; Extracellular Space; Glycerides; Humans; In Vitro Techniques; Ionomycin; Isoquinolines; Kinetics; Piperazines; Protein Kinase C; T-Lymphocytes | 1989 |
Induction of high-affinity interleukin 2 receptors on human T lymphocytes. The role of calcium and protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Diglycerides; Egtazic Acid; Ethers; Humans; Interleukin-2; Ionomycin; Isoquinolines; Phytohemagglutinins; Piperazines; Protein Kinase C; Receptors, Interleukin-2; T-Lymphocytes; Tetradecanoylphorbol Acetate | 1989 |
Effects of EGTA and calmodulin, neutral thiol proteinases and protein kinase C inhibitors on loss of chicken pineal serotonin N-acetyltransferase activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Calmodulin; Chickens; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Egtazic Acid; Isoquinolines; Leucine; Pineal Gland; Piperazines; Protein Kinase C; Protein Kinase Inhibitors | 1989 |
Paradoxical effects of retinal in neutrophil stimulation.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Cell Fractionation; Cell Membrane; Egtazic Acid; Guinea Pigs; Isoquinolines; Neutrophils; Phosphoproteins; Phosphorylation; Piperazines; Protein Kinase C; Retinaldehyde; Retinoids; Solubility; Sulfonamides; Superoxides | 1989 |
Triggering of neutrophil cytotoxicity against an antibody-coated tumour target by TPA.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antibodies, Monoclonal; Antibody-Dependent Cell Cytotoxicity; Cell Degranulation; Egtazic Acid; Humans; Isoquinolines; Leukemia; Muramidase; Neutrophils; Piperazines; Superoxides; Tetradecanoylphorbol Acetate; Tumor Cells, Cultured | 1989 |
Calcium- and phospholipid-dependent protein kinase C and phosphatidylinositol kinase: two major phosphorylation systems in the cornea.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 1-Phosphatidylinositol 4-Kinase; Animals; Cornea; Cytosol; Egtazic Acid; Epithelium; Isoquinolines; Phosphatidylserines; Phosphorylation; Phosphotransferases; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate | 1987 |
Effects of antidepressants on the inward current mediated by 5-HT3 receptors in rat nodose ganglion neurones.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Antidepressive Agents; Antidepressive Agents, Tricyclic; Egtazic Acid; Indicators and Reagents; Ion Channels; Isoquinolines; Male; Monoamine Oxidase Inhibitors; Neurons; Nodose Ganglion; Patch-Clamp Techniques; Piperazines; Protein Kinase Inhibitors; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin | 1994 |
Activation of multiple protein kinases induced by cross-linking of Fc gamma RII in human neutrophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinases; Cross-Linking Reagents; Egtazic Acid; Enzyme Activation; Genistein; Humans; Isoflavones; Isoquinolines; Molecular Sequence Data; Naphthalenes; Neutrophils; Piperazines; Polycyclic Compounds; Protein Kinase C; Protein Kinase Inhibitors; Protein Kinases; Protein-Tyrosine Kinases; Receptors, IgG; Superoxides | 1995 |
Apoptosis and its modulation in human promyelocytic HL-60 cells treated with DNA topoisomerase I and II inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Aminoquinolines; Aphidicolin; Apoptosis; Benzamides; Calcium; Calmodulin; Camptothecin; Cell Cycle; Chromatin; Cyclosporine; DNA; Egtazic Acid; Ethers, Cyclic; Humans; Isoquinolines; Leukemia, Experimental; Leukemia, Promyelocytic, Acute; Microscopy, Electron; Naphthalenes; Okadaic Acid; Phosphoprotein Phosphatases; Piperazines; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerase Inhibitors; Polycyclic Compounds; Protein Kinase C; Spermine; Staurosporine; Teniposide; Tetradecanoylphorbol Acetate; Topoisomerase I Inhibitors; Topoisomerase II Inhibitors; Tumor Cells, Cultured; Zinc | 1993 |
Dual regulation of Ca2+/calmodulin-dependent kinase II activity by membrane voltage and by calcium influx.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Imidodiphosphate; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Egtazic Acid; Electric Conductivity; Electric Stimulation; Heart; Isoenzymes; Isoproterenol; Isoquinolines; Kinetics; Membrane Potentials; Myocardium; Norepinephrine; Piperazines; Protein Kinase Inhibitors; Rats; Sulfonamides; Tetradecanoylphorbol Acetate; Thioridazine; Time Factors | 1994 |
Ca(2+)-dependent phosphorylation of myosin light chain kinase decreases the Ca2+ sensitivity of light chain phosphorylation within smooth muscle cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Sequence; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cattle; Cells, Cultured; Egtazic Acid; Fluorescein-5-isothiocyanate; Fluorescent Dyes; Isoquinolines; Kinetics; Microscopy, Fluorescence; Molecular Sequence Data; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Myosins; Peptide Fragments; Phosphorylation; Piperazines; Rhodamines; Trachea | 1994 |
Redistribution of fodrin in an in vitro wound healing model of the corneal epithelium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Carrier Proteins; Cattle; Cell Membrane; Cells, Cultured; Cornea; Cytoplasm; Egtazic Acid; Epithelial Cells; Epithelium; Isoquinolines; Membrane Proteins; Microfilament Proteins; Microscopy, Fluorescence; Naphthalenes; Piperazines; Protein Kinase C; Rabbits; Tetradecanoylphorbol Acetate; Wound Healing | 1995 |
Ca2+-dependent and Ca2+-independent regulation of the thyroid epithelial junction complex by protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alkaloids; Animals; Calcium; Cells, Cultured; Colforsin; Cyclic AMP-Dependent Protein Kinases; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Epithelium; Isoquinolines; Membrane Proteins; Phosphoproteins; Piperazines; Staurosporine; Swine; Thyroid Gland; Thyrotropin; Tight Junctions; Trypsin; Zonula Occludens-1 Protein | 1996 |
Mechanism of catecholamine synthesis inhibition by neuropeptide Y: role of Ca2+ channels and protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Adenine; Animals; Calcium Channel Blockers; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Carcinogens; Catecholamines; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Imidazoles; Ion Channel Gating; Isoquinolines; Neuropeptide Y; Nifedipine; omega-Conotoxin GVIA; PC12 Cells; Peptides; Piperazines; Protein Kinase C; Protein Kinases; Protein Synthesis Inhibitors; Rats; Tetradecanoylphorbol Acetate; Thionucleotides | 1996 |
Phosphoinositide signalling in human neuroblastoma cells: biphasic effect of Li+ on the level of the inositolphosphate second messengers.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetylcholine; Atropine; Calcium; Egtazic Acid; Enzyme Inhibitors; Humans; Indoles; Inositol 1,4,5-Trisphosphate; Inositol Phosphates; Lithium; Maleimides; Neuroblastoma; Nickel; Phosphatidylinositols; Protein Kinase Inhibitors; Signal Transduction; Staurosporine; Tumor Cells, Cultured | 1996 |
Inhibition of calcineurin inhibits the desensitization of capsaicin-evoked currents in cultured dorsal root ganglion neurones from adult rats.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Animals; Calcineurin; Calcium; Calmodulin-Binding Proteins; Capsaicin; Cells, Cultured; Chelating Agents; Cyclosporine; Drug Resistance; Egtazic Acid; Enzyme Inhibitors; Evoked Potentials; Ganglia, Spinal; Ion Channel Gating; Ion Channels; Ligands; Phosphoprotein Phosphatases; Phosphorylation; Protein Kinase Inhibitors; Rats | 1996 |
Gap junctional intercellular communication of bovine luteal cells from several stages of the estrous cycle: effects of prostaglandin F2 alpha, protein kinase C and calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcium; Cattle; Corpus Luteum; Dinoprost; Egtazic Acid; Estrus; Female; Gap Junctions; Luteinizing Hormone; Progesterone; Protein Kinase C; Tissue Plasminogen Activator | 1996 |
Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Biological Transport; Calcium; Cells, Cultured; Chlorides; Colon; Egtazic Acid; Electrolytes; Ergolines; Guanosine 5'-O-(3-Thiotriphosphate); Intestinal Mucosa; Male; Membrane Potentials; Patch-Clamp Techniques; Potassium; Protein Kinase Inhibitors; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Serotonin | 1997 |
Deoxycholic acid and SCFA-induced apoptosis in the human tumor cell-line HT-29 and possible mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Butyrates; Butyric Acid; Calcium; Chelating Agents; Colonic Neoplasms; Cycloheximide; Dactinomycin; Deoxycholic Acid; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Genistein; Humans; Isoflavones; Propionates; Protein Synthesis Inhibitors; Time Factors; Tumor Cells, Cultured | 1997 |
Protein kinase C modulator effects on parathyroid hormone-induced intracellular calcium and morphologic changes in UMR 106-H5 osteoblastic cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Animals; Calcium; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Fluorescent Dyes; Fura-2; Inositol 1,4,5-Trisphosphate; Naphthalenes; Osteoblasts; Osteosarcoma; Parathyroid Hormone; Protein Kinase C; Rats; Tumor Cells, Cultured | 1997 |
ATP- and EGF-stimulated phosphatidulinositol synthesis by two different pathways, phospholipase D and diacylglycerol kinase, in A-431 epidermoid carcinoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Bradykinin; Calcimycin; Calcium; Carcinoma, Squamous Cell; Chelating Agents; Choline; Diacylglycerol Kinase; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Epidermal Growth Factor; ErbB Receptors; Humans; Ionophores; Neoplasm Proteins; Pertussis Toxin; Phosphatidic Acids; Phosphatidylinositol Diacylglycerol-Lyase; Phosphatidylinositols; Phospholipase D; Phosphotransferases (Alcohol Group Acceptor); Pyrimidinones; Receptors, Purinergic P2; Signal Transduction; Staurosporine; Sulfonamides; Thiazoles; Tumor Cells, Cultured; Type C Phospholipases; Virulence Factors, Bordetella | 1996 |
Reorganization of the cortical actin cytoskeleton during maturation division in the Tubifex egg: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actin Cytoskeleton; Actins; Animals; Calcimycin; Calcium; Cell Size; Chelating Agents; Cytoskeleton; Egtazic Acid; Enzyme Inhibitors; Fluorescent Dyes; Ionophores; Meiosis; Microinjections; Microscopy, Fluorescence; Oligochaeta; Oocytes; Protein Kinase C; Spectrophotometry; Staurosporine; Tetradecanoylphorbol Acetate | 1997 |
The requirements for Ca2+, protein phosphorylation, and dephosphorylation for ethylene signal transduction in Pisum sativum L.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Oxidoreductases; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cyclin-Dependent Kinases; Egtazic Acid; Enzyme Inhibitors; Ethylenes; Phosphoprotein Phosphatases; Phosphorylation; Pisum sativum; Plant Proteins; Protein Kinase C; Signal Transduction; Verapamil | 1997 |
ETA receptor mediated inhibition of intracellular pH regulation in cultured bovine corneal epithelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amiloride; Animals; Arsenicals; Calcium-Calmodulin-Dependent Protein Kinases; Cattle; Cells, Cultured; Chelating Agents; Cyclosporine; Diuretics; Egtazic Acid; Endothelin Receptor Antagonists; Endothelin-1; Enzyme Inhibitors; Epithelium, Corneal; Hydrogen-Ion Concentration; Immunosuppressive Agents; Intracellular Fluid; Naphthalenes; Okadaic Acid; Peptides, Cyclic; Phosphoprotein Phosphatases; Protein Kinase C; Receptors, Endothelin; Spectrometry, Fluorescence; Tetradecanoylphorbol Acetate | 1998 |
Signal transduction pathways mediating CCK-induced gallbladder muscle contraction.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzimidazoles; Calcium; Calmodulin; Cats; Cell Membrane; Cholecystokinin; Diglycerides; Egtazic Acid; Female; Gallbladder; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Inositol 1,4,5-Trisphosphate; Isoenzymes; Male; Muscle Contraction; Muscle, Smooth; Pertussis Toxin; Phospholipase C beta; Potassium Chloride; Signal Transduction; Type C Phospholipases; Virulence Factors, Bordetella | 1998 |
Tumor cell resistance to topoisomerase II poisons: role for intracellular free calcium in the sensitization by inhibitors or calcium-calmodulin-dependent enzymes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; DNA Damage; Drug Resistance, Neoplasm; Egtazic Acid; Enzyme Inhibitors; Etoposide; HL-60 Cells; Humans; Topoisomerase II Inhibitors | 1998 |
Vasopressin-induced disruption of actin cytoskeletal organization and canalicular function in isolated rat hepatocyte couplets: possible involvement of protein kinase C.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Antioxidants; Bile Canaliculi; Bucladesine; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Carbazoles; Cells, Cultured; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Cytoskeleton; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Imidazoles; Indoles; Leupeptins; Liver; Male; Microscopy, Electron, Scanning; Phorbol 12,13-Dibutyrate; Protein Kinase C; Pyrroles; Rats; Rats, Wistar; Tight Junctions; Vacuoles; Vasopressins | 1998 |
Orientation change of cardiocytes induced by cyclic stretch stimulation: time dependency and involvement of protein kinases.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actinin; Actins; Animals; Benzoquinones; Cells, Cultured; Egtazic Acid; Enzyme Inhibitors; Gadolinium; Immunoblotting; Isoquinolines; Lactams, Macrocyclic; Muscle Spindles; Myocardium; Myofibrils; Physical Stimulation; Protein Kinase C; Protein-Tyrosine Kinases; Quinones; Rats; Rats, Wistar; Rifabutin; Signal Transduction; Sulfonamides; Time Factors | 1999 |
Calcium-dependent mechanisms involved in presynaptic long-term depression at the hippocampal mossy fibre-CA3 synapse.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Anticonvulsants; Calcium; Chelating Agents; Cyclopropanes; Egtazic Acid; Enzyme Inhibitors; Excitatory Postsynaptic Potentials; Glycine; Long-Term Potentiation; Magnesium; Mice; Mice, Inbred ICR; Mossy Fibers, Hippocampal; Neural Inhibition; Neuronal Plasticity; Phosphorylation; Presynaptic Terminals; Receptors, Metabotropic Glutamate | 1999 |
Agonist-induced regulation of myosin phosphatase activity in human platelets through activation of Rho-kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Blood Platelets; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Myosin-Light-Chain Phosphatase; Myosins; Phosphoprotein Phosphatases; Phosphorylation; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; rhoA GTP-Binding Protein | 1999 |
Effects of eosinophil granule major basic protein on phosphatidylcholine secretion in rat type II pneumocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blood Proteins; Calcium; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Eosinophil Granule Proteins; Guinea Pigs; Inflammation Mediators; Isoquinolines; Lung; Phosphatidylcholines; Protein Kinase Inhibitors; Rats; Ribonucleases; Sulfonamides | 1999 |
alpha1-adrenergic receptor activation of c-fos expression in transfected rat-1 fibroblasts: role of Ca2+.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adrenergic alpha-1 Receptor Antagonists; Animals; Calcium; Calmodulin; Doxazosin; Egtazic Acid; Enzyme Inhibitors; Fibroblasts; Gene Expression Regulation; Genes, fos; Imidazoles; Kinetics; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; Rats; Receptors, Adrenergic, alpha-1; Recombinant Proteins; Sulfonamides; Transcription, Genetic; Trifluoperazine | 1999 |
Effect of calcium on the uptake of glutamate by synaptosomes: possible involvement of two different mechanisms.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cerebral Cortex; Chelating Agents; Egtazic Acid; Electrophysiology; Enzyme Inhibitors; Glutamic Acid; Male; Rats; Rats, Sprague-Dawley; Sodium Channel Blockers; Sodium Channels; Synaptosomes; Tetrodotoxin; Trifluoperazine | 1999 |
Platelet-derived growth factor-induced activation of sphingosine kinase requires phosphorylation of the PDGF receptor tyrosine residue responsible for binding of PLCgamma.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amino Acid Substitution; Animals; Calcium; Cell Division; Cell Line; Chelating Agents; DNA; Dogs; Egtazic Acid; Enzyme Activation; Isoenzymes; Mutagenesis, Site-Directed; Phenylalanine; Phospholipase C gamma; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Platelet-Derived Growth Factor; Receptor Protein-Tyrosine Kinases; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Thapsigargin; Transfection; Type C Phospholipases; Tyrosine | 1999 |
Platelet shape change is mediated by both calcium-dependent and -independent signaling pathways. Role of p160 Rho-associated coiled-coil-containing protein kinase in platelet shape change.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Blood Platelets; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Humans; Intracellular Signaling Peptides and Proteins; Myosins; Phosphorylation; Protein Kinase C; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Signal Transduction | 1999 |
Modulation of carbachol-stimulated AP-1 DNA binding activity by therapeutic agents for bipolar disorder in human neuroblastoma SH-SY5Y cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Antipsychotic Agents; Bipolar Disorder; Calcium; Calcium Signaling; Carbachol; Carbamazepine; Chelating Agents; DNA; Dose-Response Relationship, Drug; Edetic Acid; Egtazic Acid; Gene Expression Regulation; Humans; Indoles; Ionomycin; Ionophores; Lithium; Muscarinic Agonists; Nerve Tissue Proteins; Neuroblastoma; Neurons; Phosphatidylinositols; Protein Binding; Protein Kinase C; Signal Transduction; Tetradecanoylphorbol Acetate; Transcription Factor AP-1; Tumor Cells, Cultured; Valproic Acid | 1999 |
The protein kinase inhibitor 1-(5-isoquinolinylsulfonyl)-2-methyl-piperzine (H-7) prevents and reverses Ca(2+)-mediated injury in isolated rat hepatocyte couplets.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Adenosine Triphosphate; Animals; Calcimycin; Calcium; Cell Membrane; Chelating Agents; Cholic Acids; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Fluoresceins; Fluorescence; Fluorescent Dyes; In Vitro Techniques; Ionophores; Liver; Male; Protein Kinase Inhibitors; Rats; Rats, Wistar; Tight Junctions; Vacuoles | 1999 |
N-methyl-D-aspartate enhancement of the glycine response in the rat sacral dorsal commissural neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Calcium Channels; Calcium-Calmodulin-Dependent Protein Kinases; Chloride Channels; Drug Synergism; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycine; In Vitro Techniques; Kinetics; Membrane Potentials; N-Methylaspartate; Neurons; Rats; Rats, Wistar; Spinal Cord | 2000 |
A novel protein kinase from Brassica juncea stimulated by a protozoan calcium binding protein. Purification and partial characterization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Brassica; Calcium; Calcium Signaling; Calcium-Binding Proteins; Calmodulin; Chelating Agents; Egtazic Acid; Entamoeba histolytica; Histones; Immunoglobulin G; Intercellular Signaling Peptides and Proteins; Peptides; Phosphorylation; Phosphoserine; Plant Proteins; Protein Kinases; Protein Processing, Post-Translational; Protozoan Proteins; Recombinant Fusion Proteins; Staurosporine; Sulfonamides | 2000 |
Stimulation of Ca(2+)-independent exocytosis in rat pituitary gonadotrophs by G-protein.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Aluminum Compounds; Animals; Calcium; Calcium-Transporting ATPases; Cyclic AMP; Cytoplasmic Granules; Cytosol; Egtazic Acid; Enzyme Inhibitors; Exocytosis; Fluorides; Fluorometry; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanylyl Imidodiphosphate; Male; Patch-Clamp Techniques; Photolysis; Pituitary Gland, Anterior; Protein Kinase C; Rats; Staurosporine | 2000 |
Influence of sustained mechanical stress on Egr-1 mRNA expression in cultured human endothelial cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Blotting, Northern; Cell Line; Cells, Cultured; Chelating Agents; Colchicine; DNA-Binding Proteins; Early Growth Response Protein 1; Egtazic Acid; Endothelium, Vascular; Enzyme Inhibitors; Gadolinium; Humans; Immediate-Early Proteins; Isoquinolines; Microscopy, Fluorescence; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-fos; RNA, Messenger; Signal Transduction; Stress, Mechanical; Sulfonamides; Transcription Factors; Umbilical Veins | 2000 |
The stimulation of MAP kinase by 1,25(OH)(2)-vitamin D(3) in skeletal muscle cells is mediated by protein kinase C and calcium.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcimycin; Calcitriol; Calcium; Calmodulin; Chick Embryo; Egtazic Acid; Enzyme Activation; Fluphenazine; Indoles; Maleimides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Muscle, Skeletal; Naphthalenes; Neomycin; Phosphorylation; Protein Kinase C; Tetradecanoylphorbol Acetate; Thapsigargin; Type C Phospholipases; Verapamil | 2001 |
Calmodulin-dependent and -independent apoptosis in cell of a Drosophila neuronal cell line.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apoptosis; Calcimycin; Calcium; Calmodulin; Caspases; Cell Line; Chelating Agents; Cycloheximide; Dactinomycin; DNA Fragmentation; Drosophila melanogaster; Egtazic Acid; Enzyme Inhibitors; Ionophores; Neurons; Protein Synthesis Inhibitors; Sulfonamides | 2000 |
Gastrin inhibits cholangiocarcinoma growth through increased apoptosis by activation of Ca2+-dependent protein kinase C-alpha.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Apoptosis; Benzodiazepinones; Cell Division; Cholangiocarcinoma; Egtazic Acid; Enzyme Activation; Gastrins; Humans; Isoenzymes; Phenylurea Compounds; Protein Kinase C; Protein Kinase C-alpha; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin; Tumor Cells, Cultured | 2001 |
Intracellular calcium reduces light-induced excitatory post-synaptic responses in salamander retinal ganglion cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 6-Cyano-7-nitroquinoxaline-2,3-dione; Ambystoma; Animals; Caffeine; Calcium; Central Nervous System Stimulants; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; In Vitro Techniques; Ion Channels; Light; Patch-Clamp Techniques; Protein Kinase Inhibitors; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Retinal Ganglion Cells; Sodium | 2001 |
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR1-expressing CHO cells via calcium/calmodulin signaling.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; CHO Cells; Cricetinae; Cytoskeleton; Edetic Acid; Egtazic Acid; Enzyme Inhibitors; Estrenes; Focal Adhesion Protein-Tyrosine Kinases; Focal Adhesions; Glutamic Acid; Indoles; Kinetics; Maleimides; Phosphorylation; Protein-Tyrosine Kinases; Pyrrolidinones; Receptor, Metabotropic Glutamate 5; Receptors, Metabotropic Glutamate; Recombinant Proteins; Transfection; Type C Phospholipases | 2001 |
Functional characterization of P2Y and P2X receptors in human eosinophils.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Calcium; Cells, Cultured; Chelating Agents; Chemotaxis; Egtazic Acid; Enzyme Inhibitors; Eosinophils; Humans; Intracellular Fluid; Macrophage-1 Antigen; Nucleotides; Pertussis Toxin; Purinergic P2 Receptor Antagonists; Receptors, Purinergic P2; Respiratory Burst; Up-Regulation; Virulence Factors, Bordetella | 2001 |
Effects of second messengers on gap junctional intercellular communication of ovine luteal cells throughout the estrous cycle.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Blotting, Western; Bucladesine; Calcimycin; Calcium; Cells, Cultured; Chelating Agents; Culture Media, Conditioned; Cyclic AMP; Egtazic Acid; Enzyme Inhibitors; Estrous Cycle; Female; Fluorescent Antibody Technique; Gap Junctions; Immunohistochemistry; Ionophores; Luteal Cells; Progesterone; Protein Kinase C; Second Messenger Systems; Sheep; Tetradecanoylphorbol Acetate; Thionucleotides | 2001 |
Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Analysis of Variance; Animals; Bucladesine; Calcium; Carbazoles; Chelating Agents; Cholagogues and Choleretics; Cholestasis; Cholic Acids; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Activation; Enzyme Inhibitors; Indoles; Liver; Male; Protein Kinase C; Pyrroles; Rats; Signal Transduction; Staurosporine; Taurochenodeoxycholic Acid; Taurolithocholic Acid | 2002 |
Mechanisms of mitogenic and anti-apoptotic signaling by glucose-dependent insulinotropic polypeptide in beta(INS-1)-cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Alloxan; Androstadienes; Apoptosis; Arginase; B-Lymphocytes; Benzylamines; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Cell Line; Chelating Agents; Cyclic AMP-Dependent Protein Kinases; Deoxyglucose; Egtazic Acid; Enzyme Inhibitors; Flavonoids; Gastric Inhibitory Polypeptide; Genistein; Glucokinase; Glucose; Humans; Indoles; Isoquinolines; Maleimides; MAP Kinase Kinase 1; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Mitosis; Phosphoinositide-3 Kinase Inhibitors; Plasmids; Protein Kinase C; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Signal Transduction; Sulfonamides; Wortmannin | 2002 |
Insulin inhibits secretin-induced ductal secretion by activation of PKC alpha and inhibition of PKA activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Animals; Benzopyrans; Bile; Bile Canaliculi; Bile Ducts; Calcium; Chelating Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Egtazic Acid; Enzyme Inhibitors; Hypoglycemic Agents; Insulin; Isoenzymes; Male; Protein Kinase C; Protein Kinase C-alpha; Rats; Rats, Inbred F344; Receptor, Insulin; Secretin | 2002 |
Dopaminergic inhibition of secretin-stimulated choleresis by increased PKC-gamma expression and decrease of PKA activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetophenones; Alkaloids; Animals; Benzophenanthridines; Benzopyrans; Bicarbonates; Bile; Bile Ducts, Intrahepatic; Chelating Agents; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dopamine; Dopamine Agonists; Down-Regulation; Egtazic Acid; Enzyme Inhibitors; Epithelium; Liver; Male; Phenanthridines; Protein Kinase C; Quinolines; Rats; Rats, Inbred F344; Receptors, Dopamine D2; Secretin | 2003 |
Calmodulin and calmodulin-dependent kinase II mediate neuronal cell death induced by depolarization.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Benzylamines; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Calmodulin; Cell Death; Cells, Cultured; Cerebral Cortex; Egtazic Acid; Enzyme Inhibitors; Fetus; Kinetics; Membrane Potentials; Neurons; NG-Nitroarginine Methyl Ester; Nifedipine; Nitriles; Pyrethrins; Rats; Sulfonamides; Tacrolimus; Trifluoperazine; Veratridine | 2003 |
Components of the intracellular cAMP system supporting the olfactory reception of amyl alcohol.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenylyl Cyclases; Aluminum Compounds; Animals; Antimetabolites; Caffeine; Calcium Channel Blockers; Calcium Chloride; Chelating Agents; Chlortetracycline; Colforsin; Cyclic AMP; Dideoxyadenosine; Egtazic Acid; Fluorides; In Vitro Techniques; Ionomycin; Ionophores; Microscopy, Fluorescence; Nifedipine; Olfactory Mucosa; Pentanols; Phosphodiesterase Inhibitors; Rana temporaria; Reaction Time; Signal Transduction; Smell | 2003 |
Ca(2+)-inactivated K+ current is modulated by endothelin-1 in B-16 murine melanoma cells.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Calcium; Cell Line, Tumor; Cobalt; Egtazic Acid; Endothelin-1; Humans; Melanoma, Experimental; Patch-Clamp Techniques; Pertussis Toxin; Potassium Channel Blockers; Potassium Channels, Calcium-Activated; Protein Kinase C | 2003 |
Activity-dependent long-term potentiation of intrinsic excitability in hippocampal CA1 pyramidal neurons.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 2-Amino-5-phosphonovalerate; 4-Aminopyridine; 6-Cyano-7-nitroquinoxaline-2,3-dione; Animals; Anisomycin; Bicuculline; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Egtazic Acid; Emetine; Excitatory Amino Acid Antagonists; Learning; Long-Term Potentiation; Patch-Clamp Techniques; Phosphinic Acids; Potassium Channels; Propanolamines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Sodium Channels | 2005 |
The role of intracellular Ca2+ in the regulation of proteinase-activated receptor-2 mediated nuclear factor kappa B signalling in keratinocytes.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Calcium; Cell Line; Chelating Agents; Egtazic Acid; Enzyme Inhibitors; Estrenes; Humans; I-kappa B Kinase; Indoles; Keratinocytes; Maleimides; Mitogen-Activated Protein Kinases; NF-kappa B; Oligonucleotides; Phosphodiesterase Inhibitors; Protein Binding; Protein Kinase C; Protein Serine-Threonine Kinases; Pyrrolidinones; Receptor, PAR-2; Signal Transduction; Tacrolimus; Tetradecanoylphorbol Acetate; Trypsin; Type C Phospholipases | 2005 |
Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Azepines; Calcium; Dose-Response Relationship, Drug; Egtazic Acid; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Myosin-Light-Chain Kinase; Norepinephrine; Potassium; Protein Kinase Inhibitors; Protein Serine-Threonine Kinases; Purinergic P2 Receptor Agonists; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P2; Receptors, Purinergic P2X; rho-Associated Kinases; Vas Deferens | 2006 |
Activity-dependent initiation of a prolonged depolarization in aplysia bag cell neurons: role for a cation channel.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Aplysia; Calmodulin-Binding Proteins; Cations; Cells, Cultured; Chelating Agents; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Egtazic Acid; Electric Stimulation; Enzyme Inhibitors; Ion Channels; Membrane Potentials; Membrane Transport Modulators; Neurons; Patch-Clamp Techniques; Potassium Channel Blockers; Tetraethylammonium; Time Factors | 2007 |
Receptor-mediated tobacco toxicity: acceleration of sequential expression of alpha5 and alpha7 nicotinic receptor subunits in oral keratinocytes exposed to cigarette smoke.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; alpha7 Nicotinic Acetylcholine Receptor; Bungarotoxins; Butadienes; Carbazoles; Conotoxins; Egtazic Acid; GATA2 Transcription Factor; Humans; Imidazoles; Indoles; Keratinocytes; Nerve Tissue Proteins; Nicotine; Nitriles; Phenols; Polyenes; Polyunsaturated Alkamides; Pyridines; Receptors, Nicotinic; RNA, Small Interfering; Signal Transduction; Smoking; Tobacco Smoke Pollution; Tyrphostins; Up-Regulation | 2008 |
Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Benzophenanthridines; Body Weight; Calcium; Chick Embryo; Egtazic Acid; Endothelin-1; Enzyme Inhibitors; Femoral Artery; Hypoxia; NG-Nitroarginine Methyl Ester; Oxadiazoles; Phenylephrine; Phorbol 12,13-Dibutyrate; Potassium Chloride; Protein Kinase C; Protein Kinase Inhibitors; Quinoxalines; rho-Associated Kinases; Vasoconstriction | 2010 |
CRP1, a protein localized in filopodia of growth cones, is involved in dendritic growth.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Actins; Analysis of Variance; Animals; Calcium; Calcium Channel Blockers; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cells, Cultured; Chelating Agents; Chlorocebus aethiops; CREB-Binding Protein; Cystatins; Dendrites; Egtazic Acid; Embryo, Mammalian; Enzyme Inhibitors; Female; Green Fluorescent Proteins; Growth Cones; Hippocampus; Male; Microscopy, Confocal; Neurites; Neurons; Nifedipine; Potassium Chloride; Pseudopodia; Rats; RNA, Messenger; RNA, Small Interfering; Transfection; Up-Regulation; Valine | 2011 |
γ-[Glu]
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Cell Line; Cell Proliferation; Cell Survival; Cholecystokinin; Dipeptides; Egtazic Acid; Gastrointestinal Hormones; Glucagon-Like Peptide 1; Humans; Naphthalenes; Peptides; Receptors, Calcium-Sensing | 2019 |