Page last updated: 2024-09-03

efonidipine and verapamil

efonidipine has been researched along with verapamil in 8 studies

Compound Research Comparison

Studies
(efonidipine)
Trials
(efonidipine)
Recent Studies (post-2010)
(efonidipine)
Studies
(verapamil)
Trials
(verapamil)
Recent Studies (post-2010) (verapamil)
129183017,6211,5272,067

Protein Interaction Comparison

ProteinTaxonomyefonidipine (IC50)verapamil (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)6.8
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.297
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
ATP-dependent translocase ABCB1Homo sapiens (human)2.2346
Cytochrome P450 3A4Homo sapiens (human)3.8008
Alpha-2A adrenergic receptorHomo sapiens (human)0.579
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)3.02
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
Catechol O-methyltransferaseHomo sapiens (human)0.2
Potassium voltage-gated channel subfamily A member 3Homo sapiens (human)8
Histamine H2 receptorHomo sapiens (human)2.59
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.442
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.297
5-hydroxytryptamine receptor 1BRattus norvegicus (Norway rat)3.02
Sodium-dependent serotonin transporterHomo sapiens (human)0.24
Multidrug resistance-associated protein 1 Homo sapiens (human)5.598
D(3) dopamine receptorHomo sapiens (human)0.186
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.165
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)6.8
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.2
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.3945
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.2
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.175
Broad substrate specificity ATP-binding cassette transporter ABCG2Homo sapiens (human)1.1934

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (12.50)18.2507
2000's4 (50.00)29.6817
2010's3 (37.50)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Masumiya, H; Saito, W; Sekine, T; Shigenobu, K; Sijuku, T; Sugahara, M; Tanaka, H; Taniguchi, H; Terada, M1
Hayashi, M; Nakazato, Y; Saruta, T; Yamaji, Y1
Fukuda, Y; Hara, M; Kinebuchi, O; Kurita, Y; Mitamura, H; Miyoshi, S; Ogawa, S; Ohashi, N; Shiroshita-Takeshita, A; Takatsuki, S; Tanimoto, K1
Perez-Reyes, E; Van Deusen, AL; Vitko, I1
Ball, CJ; Beltrame, JF; Saint, DA; Turner, SP; Wilson, DP1
Ikeda, K; Saito, T; Tojo, K1
Chattipakorn, N; Chattipakorn, S; Chinda, K; Fucharoen, S; Kumfu, S1
Chattipakorn, N; Chattipakorn, S; Fucharoen, S; Kumfu, S1

Other Studies

8 other study(ies) available for efonidipine and verapamil

ArticleYear
Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem.
    General pharmacology, 1996, Volume: 27, Issue:3

    Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Wistar; Verapamil

1996
The effects of calcium channel blockers on nuclear factor kappa B activation in the mesangium cells.
    Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:5

    Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcimycin; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Carcinogens; Cells, Cultured; Dihydropyridines; Gene Expression; Genes, Reporter; Glomerular Mesangium; Humans; Ionophores; Luciferases; NF-kappa B; Nifedipine; Nitrophenols; Organophosphorus Compounds; Tetradecanoylphorbol Acetate; Verapamil

2000
A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling.
    Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:3

    Topics: Administration, Oral; Animals; Atrial Fibrillation; Atrioventricular Node; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiac Pacing, Artificial; Dihydropyridines; Dogs; Electrophysiology; Forecasting; Heart Atria; Japan; Male; Nitrophenols; Organophosphorus Compounds; Refractory Period, Electrophysiological; Research Design; Time Factors; Verapamil

2004
Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:2

    Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Dihydropyridines; Humans; Mibefradil; Nitrophenols; Organophosphorus Compounds; Verapamil

2009
Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade.
    Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:4

    Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Mibefradil; Microvessels; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Sprague-Dawley; Subcutaneous Fat; Vasoconstriction; Verapamil

2009
Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells.
    The Tohoku journal of experimental medicine, 2011, Volume: 224, Issue:4

    Topics: Adrenocortical Carcinoma; Angiotensin II; Bucladesine; Calcium Channel Blockers; Cell Line, Tumor; Dehydroepiandrosterone Sulfate; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydrocortisone; Nitrophenols; Organophosphorus Compounds; Phosphoproteins; RNA, Messenger; Verapamil

2011
T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice.
    European journal of haematology, 2012, Volume: 88, Issue:6

    Topics: Animals; Azoles; Base Sequence; beta-Thalassemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiovascular System; Deferoxamine; Dihydropyridines; Disease Models, Animal; DNA Primers; Heart Rate; Humans; Iron; Iron Chelating Agents; Iron, Dietary; Isoindoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Nifedipine; Nitrophenols; Organ Size; Organophosphorus Compounds; Organoselenium Compounds; RNA, Messenger; Ventricular Function, Left; Verapamil

2012
Ferric iron uptake into cardiomyocytes of β-thalassemic mice is not through calcium channels.
    Drug and chemical toxicology, 2013, Volume: 36, Issue:3

    Topics: Animals; Azoles; beta-Thalassemia; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, T-Type; Cation Transport Proteins; Cell Survival; Cells, Cultured; Deferoxamine; Dihydropyridines; Disease Models, Animal; Ferric Compounds; Heart Ventricles; Iron Overload; Isoindoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Nitrophenols; Organophosphorus Compounds; Organoselenium Compounds; Quaternary Ammonium Compounds; Receptors, Transferrin; Verapamil

2013