Page last updated: 2024-09-03

efonidipine and nitrophenols

efonidipine has been researched along with nitrophenols in 119 studies

Compound Research Comparison

Studies (efonidipine)	Trials (efonidipine)	Recent Studies (post-2010) (efonidipine)	Studies (nitrophenols)	Trials (nitrophenols)	Recent Studies (post-2010) (nitrophenols)
129	18	30	7,412	99	1,742

Research

Studies (119)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	39 (32.77)	18.2507
2000's	43 (36.13)	29.6817
2010's	32 (26.89)	24.3611
2020's	5 (4.20)	2.80

Authors

Authors	Studies
Kobayashi, M; Niwa, M; Nozaki, M; Tsurumi, K	1
Masuda, Y; Sakai, T; Tanaka, S; Tomita, K; Yokoyama, T	1
Kamikawaji, Y; Sakoda, R; Seto, K	1
Matsumoto, H; Sakoda, R; Seto, K	1
Hoshino, T; Kaburagi, T; Mori, N; Sakata, K; Yokoyama, S; Yoshida, H	1
Kokubun, S; Saigusa, A; Tamura, T	1
Kasuya, Y; Masuda, Y; Sakai, T; Tanaka, S; Yamashita, T	2
Hongo, K; Kurihara, S; Tanaka, E; Tanaka, T	1
Furuichi, H; Ito, S; Izumi, J; Kurimoto, T; Matsumura, T; Mori, T; Nishi, N; Suda, H; Takei, M; Tanaka, Y	1
Masuda, Y; Shudo, C; Sugita, H; Tanaka, S; Yamashita, T; Yotsumoto, T	1
Kasuya, Y; Masuda, Y; Miyajima, M; Shigenobu, K; Shudo, C; Tanaka, S	1
Furukawa, S; Hayashi, K; Hirata, H; Masuda, Y; Shudo, C; Sugita, H; Tanaka, S; Tomita, K	1
Furukawa, S; Hayashi, K; Hirata, H; Masuda, Y; Shudo, C; Tamura, T; Yamamoto, O	1
Masuda, Y; Shudo, C; Sugita, H; Tanaka, S; Tomita, K	1
Kasuya, Y; Masuda, Y; Sakai, T; Shigenobu, K; Shudo, C; Tanaka, S	2
Kitahara, M; Masuda, Y; Saito, Y; Sakashita, M; Shudo, C; Tanaka, S; Toyoda, K; Yamashita, T	1
Higashino, R; Ito, S; Kurimoto, T; Matsuda, K; Takei, M; Tanaka, T	1
Kitahara, M; Saito, Y; Sakashita, M; Tanaka, S; Toyoda, K; Yamashita, T	1
Kamikawaji, Y; Nakabeppu, H; Nakajima, A; Shinozaki, Y	1
Masumiya, H; Saito, W; Sekine, T; Shigenobu, K; Sijuku, T; Sugahara, M; Tanaka, H; Taniguchi, H; Terada, M	1
Fujikura, N; Masuda, Y; Shikada, K; Tanaka, S; Yokoyama, T	3
Asada, M; Nakabeppu, H; Oda, T; Shinozaki, Y; Yajima, T	1
Furukawa, S; Hayashi, K; Hirata, H; Masuda, Y; Shikada, K; Shudo, C; Sugita, H; Tamura, T; Tanaka, S; Tomita, K	1
Fujii, K; Ichikawa, H; Inagaki, Y; Iwata, J; Karaki, A; Kobayashi, S; Kuwabara, Y; Saito, T; Takeda, K; Takizawa, T; Tomiya, H; Toyosaki, T; Yamada, K; Yamazaki, Y	1
Abiko, Y; Ichihara, K; Yokoyama, T	2
Fukuda, Y; Higashino, R; Jin, H; Kurimoto, T; Sato, R; Tamaki, H	1
Fukuta, Y; Higashino, R; Inoue, N; Jin, H; Kurimoto, T; Sato, R; Tamaki, H	1
Masumiya, H; Shigenobu, K; Tanaka, H	1
Matsuoka, T; Nishizaki, T; Nomura, T	1
Shou, I; Takeda, M; Tomino, Y	1
Fujiwara, K; Hayashi, K; Kanno, Y; Saruta, T; Takenaka, T	1
Masumiya, H; Shigenobu, K; Shijuku, T; Tanaka, H	1
Han, WH; Kawabata, M; Ogawa, T; Takabatake, T	1
Kaneko, S; Shou, I; Takeda, M; Takizawa, H; Tomino, Y	1
Masumiya, H; Matsuda, T; Shigenobu, K; Tanaka, H; Tanaka, Y	1
Hayashi, M; Nakazato, Y; Saruta, T; Yamaji, Y	1
Fujimori, T; Ishimitsu, T; Matsuoka, H; Ono, H; Ono, Y; Watanabe, S	1
Kase, J; Masumiya, H; Shigenobu, K; Tanaka, H; Tanaka, Y	1
Hayashi, K; Honda, M; Kubota, E; Matsuda, H; Okubo, K; Ozawa, Y; Saruta, T; Tokuyama, H	1
Hayashi, K; Honda, M; Kubota, E; Matsuda, H; Okubo, K; Ozawa, Y; Saruta, T; Takamatsu, I; Tokuyama, H	1
Shigenobu, K; Tanaka, H	2
Fukuhara, S; Kanazawa, S; Nomura, S	1
Gemba, M; Kohda, Y; Nakamura, M; Notoya, M; Takashita, Y; Yamashita, J	1
Harada, K; Ito, S; Nakaya, Y; Nishikado, A; Nomura, M; Uehara, K	1
Hayashi, K; Kumagai, H; Saruta, T	1
Fukuda, Y; Hara, M; Kinebuchi, O; Kurita, Y; Mitamura, H; Miyoshi, S; Ogawa, S; Ohashi, N; Shiroshita-Takeshita, A; Takatsuki, S; Tanimoto, K	1
Furukawa, T; Honda, M; Isshiki, T; Kamiya, N; Miura, R; Mori, Y; Nukada, T; Takeshita, S	1
Kawanishi, T; Komikado, C; Namekata, I; Shigenobu, K; Shimada, H; Takeda, K; Tanaka, H	1
Hayashi, K; Homma, K; Saruta, T; Sugano, N; Wakino, S	1
Hasegawa, K; Hayashi, K; Homma, K; Kanda, T; Sugano, N; Takamatsu, I; Tatematsu, S; Wakino, S; Yoshioka, K	1
Horii, M; Imagawa, K; Kawata, H; Nakajima, T; Naya, N; Okayama, S; Saito, Y; Takaoka, M; Uemura, S	1
Higashi, Y; Ishida, M; Ishida, T; Kambe, M; Miho, N; Oshima, T; Ozono, R; Teragawa, H; Yano, Y; Yoshizumi, M	1
Hadama, T; Kaku, T; Lee, TS; Miyamoto, S; Ono, K; Perez-Reyes, E; Takebayashi, S; Uchino, T	1
Goto, Y; Ishii, M	1
Horii, M; Imagawa, K; Iwama, H; Kawata, H; Nakajima, T; Naya, N; Okayama, S; Saito, Y; Somekawa, S; Uemura, S	1
Ikeda, J; Matsubara, M; Yao, K	1
Ahn, JY; Chung, WJ; Han, SH; Kim, JA; Koh, KK; Lee, SJ; Lee, Y; Quon, MJ; Shin, EK	1
Akashiba, A; Ishimitsu, T; Kameda, T; Matsuoka, H; Minami, J; Numabe, A; Ohta, S; Ono, H; Takahashi, T; Yoshii, M	1
Fujii, M; Horie, M; Sakai, H; Tanaka, T; Tsutamoto, T; Yamamoto, T	1
Matsuzaki, M; Ohkusa, T; Ono, K; Sato, T; Suzuki, S; Takebayashi, S; Yano, M; Yoshida, MA	1
Hara, Y; Hasegawa, K; Hayashi, K; Homma, K; Hosoya, T; Kanda, T; Saruta, T; Suetsugu, Y; Sugano, N; Tatematsu, S; Tokudome, G; Utsunomiya, Y; Wakino, S; Yoshioka, K; Yoshizawa, T	1
Hojo, M; Horiba, M; Kamiya, K; Kodama, I; Lee, JK; Miwa, K; Muto, T; Opthof, T; Ueda, N; Yasui, K	1
Akaike, N; Kim, CJ; Min, BI; Ogawa, S; Shin, MC; Tanaka, E	1
Komikado, C; Nakamura, H; Namekata, I; Shigenobu, K; Suzuki, M; Takahara, A; Tanaka, H; Tsuneoka, Y	1
Wang, N; Ye, L; Yu, JX; Zhao, BQ	1
Perez-Reyes, E; Van Deusen, AL; Vitko, I	1
Ikeda, K; Inada, Y; Isaka, T; Tajima, N; Takada, Y; Tojo, K	1
Iwasaka, T; Jo, F; Maki, K; Morimoto, S	1
Mitamura, H; Ogawa, S; Ohashi, N	1
Ball, CJ; Beltrame, JF; Saint, DA; Turner, SP; Wilson, DP	1
Fujii, M; Horie, M; Kawahara, C; Nishiyama, K; Tanaka, T; Tsutamoto, T; Yamaji, M; Yamamoto, T	1
Adachi-Akahane, S; Akaike, T; Ishikawa, Y; Iwamoto, M; Iwasaki, S; Izumi-Nakaseko, H; Jiao, Q; Jin, MH; Kamiya, Y; Minamisawa, S; Nishimaki, S; Sato, M; Yokota, S; Yokoyama, U	1
Arai, Y; Fujiwara, M; Harada, M; Kinoshita, H; Kuwabara, Y; Kuwahara, K; Murakami, M; Nakagawa, Y; Nakanishi, M; Nakao, K; Takano, M; Ueshima, K; Yasuno, S	1
Ban, N; Endo, K; Kawana, H; Miyashita, Y; Nagayama, D; Ohhira, M; Oyama, T; Saiki, A; Sasaki, H; Shirai, K; Yamaguchi, T	1
Fukushima, R; Hirose, H; Koyama, H; Machida, N; Matsumoto, H; Tanaka, R; Yamane, Y	1
Adachi, M; Aritomi, S; Hayata, M; Kakizoe, Y; Kitamura, K; Ko, T; Konda, T; Miyoshi, T; Shiraishi, N; Tomita, K; Uchimura, K; Wakida, N	1
Jin, D; Miyazaki, M; Sakonjo, H; Takai, S	1
Inada, H; Ishimitsu, T; Matsuoka, H; Nakano, N; Ohba, S; Okamura, A; Takahashi, T	1
Goto, Y; Ishii, M; Ogihara, T; Rakugi, H	1
Okura, T	1
Goto, Y; Hayashi, K; Ishii, M; Saruta, T	1
Adachi-Akahane, S; Iida-Tanaka, N; Izumi-Nakaseko, H; Komikado, C; Namekata, I; Ogawa, T; Takahara, A; Tanaka, H; Tsuneoka, Y; Tsuru, H	1
Ito, S	1
Hayashi, K; Homma, K; Itoh, H; Saruta, T; Sugano, N; Tokuyama, H; Wakino, S	1
Hayashi, T; Inoue, T; Ishizaka, N; Kitada, K; Kitaura, Y; Kurumazuka, D; Matsuda, H; Matsumura, Y; Mori, T; Nagatoya, K; Ukimura, A	1
Huang, CS; Kuo, CC; Pan, MK; Tai, CH; Yang, YC	1
Ikeda, K; Saito, T; Tojo, K	1
Goto, Y; Ishii, M; Kawano, Y; Ogihara, T; Saruta, T	1
Deguchi, K; Hitomi, H; Kitaura, Y; Kobori, H; Lei, B; Masaki, T; Mori, H; Mori, T; Nagai, Y; Nakano, D; Nishiyama, A	1
Ninomiya, T	1
Choi, DH; Choi, JS; Li, C	1
Chattipakorn, N; Chattipakorn, S; Chinda, K; Fucharoen, S; Kumfu, S	1
Chang, CJ; Dickinson, BC; Guo, Q; Hu, C; Ito, S; Lu, Y; Miyata, T; Mori, T; Nakamichi, T; Oba, I; Ogawa, S; Ohsaki, Y; Sato, E; Sato, H; Sun, Y; Yoneki, Y	1
Fujita, M; Ikai, A; Mitani, S; Miyamoto, S; Ogura, C; Ono, K; Sugimoto, N; Tanaka, S	1
Chattipakorn, N; Chattipakorn, S; Fucharoen, S; Kumfu, S	1
Bub, G; Herzlinger, D; Hurtado, R	1
Han, J; Liu, H; Liu, M; Tong, Y; Wang, X; Zhang, D; Zhang, L; Zhao, H	1
Chattipakorn, N; Chattipakorn, SC; Fucharoen, S; Kumfu, S	1
Deng, M; Liu, H; Liu, M; Ma, J; Tong, Y; Wang, X; Zhang, D; Zhang, L; Zhao, H	1
Fukami, T; Inoue, M; Maeno, Y; Otsuka, M; Ozeki, T; Tagami, T	1
Chattipakorn, N; Chattipakorn, SC; Fucharoen, S; Jaiwongkam, T; Kerdphoo, S; Khamseekaew, J; Kumfu, S; Srichairatanakool, S; Wongjaikam, S	1
Asayama, K; Hanazawa, T; Hosaka, M; Imai, Y; Inoue, R; Obara, T; Ohkubo, T; Satoh, M; Watabe, D	1
Cheng, G; Huang, S; Li, H; Piao, H; Sun, Y; Zhang, Q; Zou, M	1
Huang, Y; Shen, J; Tang, L; Xiong, W; Xu, F; Zhou, D	1
Cherian, JJ; Davis, S; Raju, AR; Thomas, E	1
Chattipakorn, N; Chattipakorn, SC; Fucharoen, S; Khamseekaew, J; Srichairatanakool, S; Sripetchwandee, J; Svasti, S	1
Jha, UC; Narayan, A	1
Cheng, G; Cheng, X; Gao, J; Li, J; Piao, H; Zou, M	1
Hara, N; Hashimoto, K; Kawakami, H; Maruyama, H; Matsuda, Y; Morino, H; Satoh, K	1
Abohashrh, M; Ahmad, I; Alam, MM; Baig, MH; Dong, JJ; Sharma, T	1
Ashraf, GM; Barreto, GE; Chavda, V; Patel, SS; Rajput, R	1

Reviews

7 review(s) available for efonidipine and nitrophenols

Article	Year
Efonidipine hydrochloride: a dual blocker of L- and T-type ca(2+) channels. Cardiovascular drug reviews, 2002,Winter, Volume: 20, Issue:1 Topics: Animals; Biological Clocks; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Muscle, Smooth, Vascular; Myocardial Contraction; Nitrophenols; Organophosphorus Compounds	2002
Pathophysiological significance of T-type Ca2+ channels: T-type Ca2+ channels and drug development. Journal of pharmacological sciences, 2005, Volume: 99, Issue:3 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Drug Design; Humans; Mibefradil; Nitrophenols; Organophosphorus Compounds	2005
Pathophysiological significance of T-type Ca2+ channels: role of T-type Ca2+ channels in renal microcirculation. Journal of pharmacological sciences, 2005, Volume: 99, Issue:3 Topics: Animals; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Humans; Kidney; Kidney Diseases; Microcirculation; Nitrophenols; Organophosphorus Compounds; Renal Circulation; Signal Transduction	2005
[JATOS]. Nihon rinsho. Japanese journal of clinical medicine, 2006, Volume: 64 Suppl 6 Topics: Aged; Aged, 80 and over; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Nitrophenols; Organophosphorus Compounds; Prognosis; Prospective Studies; Randomized Controlled Trials as Topic; Single-Blind Method	2006
Development of newer calcium channel antagonists: therapeutic potential of efonidipine in preventing electrical remodelling during atrial fibrillation. Drugs, 2009, Volume: 69, Issue:1 Topics: Animals; Atrial Fibrillation; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Drug Delivery Systems; Humans; Nitrophenols; Organophosphorus Compounds	2009
T-type Ca channel blockade as a determinant of kidney protection. The Keio journal of medicine, 2010, Volume: 59, Issue:3 Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Humans; Kidney Diseases; Nitrophenols; Organophosphorus Compounds	2010
Efonidipine-Induced Exanthematic Drug Eruption and Literature Review. Journal of cardiovascular pharmacology, 2019, Volume: 73, Issue:6 Topics: Administration, Cutaneous; Administration, Oral; Aged, 80 and over; Calcium Channel Blockers; Dihydropyridines; Drug Eruptions; Exanthema; Female; Glucocorticoids; Histamine Antagonists; Humans; Nitrophenols; Organophosphorus Compounds; Skin; Treatment Outcome	2019

Trials

18 trial(s) available for efonidipine and nitrophenols

Article	Year
Plasma and urinary metabolites of efonidipine hydrochloride in man. Xenobiotica; the fate of foreign compounds in biological systems, 1996, Volume: 26, Issue:2 Topics: Adult; Animals; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Dihydropyridines; Dogs; Humans; Male; Mass Spectrometry; Nitrophenols; Organophosphorus Compounds; Rats; Species Specificity	1996
Effects of the new calcium antagonist efonidipine hydrochloride on resting and exercise hemodynamics in patients with stable effort angina. Arzneimittel-Forschung, 1996, Volume: 46, Issue:9 Topics: Angina Pectoris; Area Under Curve; Calcium Channel Blockers; Cardiac Output; Central Venous Pressure; Dihydropyridines; Electrocardiography; Exercise; Exercise Test; Female; Heart; Hemodynamics; Humans; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds; Radionuclide Imaging; Rest; Stroke Volume; Vascular Resistance	1996
Effects of efonidipine on platelet and monocyte activation markers in hypertensive patients with and without type 2 diabetes mellitus. Journal of human hypertension, 2002, Volume: 16, Issue:8 Topics: Aged; Antihypertensive Agents; Blood Cell Count; Cell Adhesion Molecules; Diabetes Mellitus, Type 2; Dihydropyridines; Female; Humans; Hypertension; Male; Middle Aged; Monocytes; Nitrophenols; Organophosphorus Compounds; Platelet Activation; Vascular Diseases	2002
Effect of efonidipine and ACE inhibitors on proteinuria in human hypertension with renal impairment. American journal of hypertension, 2003, Volume: 16, Issue:2 Topics: Angiotensin-Converting Enzyme Inhibitors; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Kidney; Kidney Diseases; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds; Proteinuria	2003
The Japanese Trial to Assess Optimal Systolic Blood Pressure in Elderly Hypertensive Patients (JATOS): protocol, patient characteristics, and blood pressure during the first 12 months. Hypertension research : official journal of the Japanese Society of Hypertension, 2005, Volume: 28, Issue:6 Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Nitrophenols; Organophosphorus Compounds; Prospective Studies; Treatment Outcome	2005
Beneficial effect of T-type calcium channel blockers on endothelial function in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2005, Volume: 28, Issue:11 Topics: Adult; Aged; Blood Flow Velocity; Brachial Artery; Calcium Channel Blockers; Case-Control Studies; Dihydropyridines; Endothelial Cells; Endothelium, Vascular; Female; Humans; Hypertension; Male; Middle Aged; Nifedipine; Nitrophenols; Organophosphorus Compounds; Vasodilation	2005
Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers. Hypertension research : official journal of the Japanese Society of Hypertension, 2006, Volume: 29, Issue:7 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Angiotensin II; Calcium Channel Blockers; Calcium Channels, T-Type; Cross-Over Studies; Depression, Chemical; Dihydropyridines; Hemodynamics; Humans; Male; Neurotransmitter Agents; Nifedipine; Nitrophenols; Organophosphorus Compounds; Renin; Water-Electrolyte Balance	2006
Efonidipine simultaneously improves blood pressure, endothelial function, and metabolic parameters in nondiabetic patients with hypertension. Diabetes care, 2007, Volume: 30, Issue:6 Topics: Adiponectin; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cholesterol, HDL; Dihydropyridines; Endothelium, Vascular; Humans; Hypertension; Leptin; Nitrophenols; Organophosphorus Compounds; Placebos; Vasodilation	2007
Efonidipine reduces proteinuria and plasma aldosterone in patients with chronic glomerulonephritis. Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:7 Topics: Adult; Aged; Aldosterone; Amlodipine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Chronic Disease; Cross-Over Studies; Dihydropyridines; Female; Glomerulonephritis; Humans; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds; Proteinuria	2007
Comparison of the effects of efonidipine and amlodipine on aldosterone in patients with hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2007, Volume: 30, Issue:8 Topics: Aged; Aged, 80 and over; Aldosterone; Amlodipine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Female; Heart Rate; Humans; Hypertension; Male; Middle Aged; Natriuretic Peptide, Brain; Nitrophenols; Norepinephrine; Organophosphorus Compounds	2007
Principal results of the Japanese trial to assess optimal systolic blood pressure in elderly hypertensive patients (JATOS). Hypertension research : official journal of the Japanese Society of Hypertension, 2008, Volume: 31, Issue:12 Topics: Aged; Aged, 80 and over; Aging; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Diuretics; Dose-Response Relationship, Drug; Endpoint Determination; Female; Humans; Hypertension; Japan; Male; Nitrophenols; Organophosphorus Compounds; Single-Blind Method; Systole	2008
Long-term effect of efonidipine therapy on plasma aldosterone and left ventricular mass index in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension, 2009, Volume: 32, Issue:8 Topics: Aged; Aldosterone; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Female; Humans; Hypertension; Hypertrophy, Left Ventricular; Male; Middle Aged; Natriuretic Peptide, Brain; Nitrophenols; Organophosphorus Compounds; Renin; Time Factors	2009
Protective effects of efonidipine, a T- and L-type calcium channel blocker, on renal function and arterial stiffness in type 2 diabetic patients with hypertension and nephropathy. Journal of atherosclerosis and thrombosis, 2009, Volume: 16, Issue:5 Topics: 8-Hydroxy-2'-Deoxyguanosine; Aged; Aldosterone; Amlodipine; Arteries; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Deoxyguanosine; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Dihydropyridines; Female; Glycated Hemoglobin; Humans; Hypertension; Kidney; Lipids; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds	2009
Effects of efonidipine, an L- and T-type calcium channel blocker, on the renin-angiotensin-aldosterone system in chronic hemodialysis patients. International heart journal, 2010, Volume: 51, Issue:3 Topics: Aged; Aldosterone; Amlodipine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cross-Over Studies; Dihydropyridines; Female; Humans; Kidney Failure, Chronic; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds; Renal Dialysis; Renin-Angiotensin System	2010
Impact of renal function on cardiovascular events in elderly hypertensive patients treated with efonidipine. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:11 Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Cardiovascular Diseases; Chronic Disease; Dihydropyridines; Female; Humans; Hypertension; Kidney; Kidney Diseases; Male; Nitrophenols; Organophosphorus Compounds; Prospective Studies	2010
Association of blood pressure control and metabolic syndrome with cardiovascular risk in elderly Japanese: JATOS study. American journal of hypertension, 2011, Volume: 24, Issue:11 Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Asian People; Blood Pressure; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Japan; Male; Metabolic Syndrome; Nitrophenols; Organophosphorus Compounds; Prevalence; Risk Factors	2011
L/T-type and L/N-type calcium-channel blockers attenuate cardiac sympathetic nerve activity in patients with hypertension. Blood pressure, 2012, Volume: 21, Issue:6 Topics: Aged; Amlodipine; Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, N-Type; Cross-Over Studies; Dihydropyridines; Female; Heart; Heart Conduction System; Hemodynamics; Humans; Hypertension; Male; Nitrophenols; Norepinephrine; Organophosphorus Compounds; Prospective Studies; Sympathetic Nervous System	2012
Effect of amlodipine, efonidipine, and trichlormethiazide on home blood pressure and upper-normal microalbuminuria assessed by casual spot urine test in essential hypertensive patients. Clinical and experimental hypertension (New York, N.Y. : 1993), 2018, Volume: 40, Issue:5 Topics: Aged; Albuminuria; Amlodipine; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Blood Pressure Monitoring, Ambulatory; Dihydropyridines; Drug Therapy, Combination; Essential Hypertension; Female; Humans; Irbesartan; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds; Tetrazoles; Trichlormethiazide; Urinalysis	2018

Other Studies

94 other study(ies) available for efonidipine and nitrophenols

Article	Year
[Affinity of Z-105 to the 1,4-dihydropyridine type calcium channel and several other receptor bindings in the central nervous system]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 100, Issue:1 Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; In Vitro Techniques; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Radioligand Assay; Rats; Receptors, Neurotransmitter; Tritium	1992
Effects of NZ-105, a new calcium antagonist, on renal function in anesthetized spontaneously hypertensive rats. Journal of cardiovascular pharmacology, 1992, Volume: 19, Issue:6 Topics: Anesthesia; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Electrolytes; Glomerular Filtration Rate; Kidney; Kidney Function Tests; Kidney Tubules; Lithium; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR; Renal Circulation; Urodynamics	1992
Synthesis of 1,4-dihydropyridine-5-phosphonates and their calcium-antagonistic and antihypertensive activities: novel calcium-antagonist 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dim ethyl-4-(3-nitrop Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:9 Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Crystallization; Dihydropyridines; In Vitro Techniques; Nitrophenols; Organophosphorus Compounds; Rats; X-Ray Diffraction	1992
Synthesis and crystal structure of optically active 2-[benzyl(phenyl)amino]ethyl 5-(5,5-dimethyl-2-oxo-1,3,2-dioxaphosphorinan-2-yl)-1,4-dihydro-2,6-dim ethyl-4-(3-nitrophenyl)-3-pyridinecarboxylate (NZ-105). Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:9 Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Crystallization; Dihydropyridines; In Vitro Techniques; Molecular Conformation; Nitrophenols; Organophosphorus Compounds; Rats; Stereoisomerism; X-Ray Diffraction	1992
[Antihypertensive effects and pharmacokinetics of NZ-105 single administration in patients with hypertension]. Nihon Jinzo Gakkai shi, 1992, Volume: 34, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Dihydropyridines; Female; Humans; Hypertension; Kidney; Male; Middle Aged; Nitrophenols; Organophosphorus Compounds	1992
Mechanisms underlying the slow onset of action of a new dihydropyridine, NZ-105, on a cultured smooth muscle cell line. Naunyn-Schmiedeberg's archives of pharmacology, 1991, Volume: 343, Issue:4 Topics: Animals; Antihypertensive Agents; Calcium Channels; Cell Line; Dihydropyridines; Electric Stimulation; Electrophysiology; Membrane Potentials; Muscle, Smooth, Vascular; Nitrophenols; Organophosphorus Compounds; Rats	1991
NZ-105, a new 1,4-dihydropyridine derivative: correlation between dihydropyridine receptor binding and inhibition of calcium uptake in rabbit aorta. Japanese journal of pharmacology, 1991, Volume: 57, Issue:3 Topics: Animals; Antihypertensive Agents; Aorta; Binding, Competitive; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Radioisotopes; Dihydropyridines; In Vitro Techniques; Kinetics; Male; Membranes; Microsomes; Muscle, Smooth, Vascular; Nitrendipine; Nitrophenols; Organophosphorus Compounds; Rabbits; Receptors, Nicotinic; Time Factors; Tritium	1991
Effects of a newly synthesized dihydropyridine, NZ-105, on intracellular Ca transients and tension in ferret ventricular muscles. Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:2 Topics: Animals; Calcium; Dihydropyridines; Ferrets; In Vitro Techniques; Myocardial Contraction; Nitrophenols; Organophosphorus Compounds; Papillary Muscles; Vasodilator Agents	1994
[Effect of efonidipine hydrochloride, a calcium channel blocker, on the experimental cerebral ischemia/anoxia]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1995, Volume: 105, Issue:6 Topics: Animals; Brain Ischemia; Calcium Channel Blockers; Dihydropyridines; Flunarizine; Hypoxia; Male; Mice; Mice, Inbred ICR; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Wistar	1995
Effects of efonidipine hydrochloride (NZ-105), a calcium antagonist, on renal function in conscious spontaneously hypertensive rats. General pharmacology, 1995, Volume: 26, Issue:2 Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diuretics; Drug Administration Schedule; Hypertension, Renal; Kidney; Male; Nitrophenols; Organophosphorus Compounds; Potassium; Rats; Rats, Inbred SHR; Renal Circulation; Sodium	1995
Cardiovascular selectivity of 1,4-dihydropyridine derivatives, efonidipine (NZ-105), nicardipine and structure related compounds in isolated guinea-pig tissues. General pharmacology, 1995, Volume: 26, Issue:2 Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Atrial Function; Calcium Channel Blockers; Depression, Chemical; Dihydropyridines; Guinea Pigs; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Muscle Relaxation; Muscle, Smooth, Vascular; Myocardial Contraction; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits	1995
Inhibitory effect of NZ-105, a 1,4-dihydropyridine derivative, on cyclic nucleotide phosphodiesterase activity. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:6 Topics: 1-Methyl-3-isobutylxanthine; 2',3'-Cyclic-Nucleotide Phosphodiesterases; 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Aorta, Thoracic; Calcium Channel Blockers; Cattle; Cyclic AMP; Cyclic GMP; Dihydropyridines; In Vitro Techniques; Intracellular Fluid; Male; Myocardium; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits	1993
Renal protective effect of efonidipine hydrochloride (NZ-105), a new calcium antagonist, in spontaneously hypertensive rats. General pharmacology, 1994, Volume: 25, Issue:8 Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Calcium Channel Blockers; Dihydropyridines; Hypertension; Kidney; Male; Nitrophenols; Organ Size; Organophosphorus Compounds; Proteinuria; Rats; Rats, Inbred SHR; Rats, Inbred WKY	1994
Influence of efonidipine hydrochloride, calcium antagonist on the epithelium of prostates in spontaneously hypertensive rats. The Journal of toxicological sciences, 1994, Volume: 19, Issue:4 Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Epithelium; Hypertension; Male; Nitrophenols; Organophosphorus Compounds; Prostate; Rats; Rats, Inbred SHR	1994
Effects of efonidipine hydrochloride (NZ-105), a new calcium antagonist, against acute renal failure in rats. General pharmacology, 1994, Volume: 25, Issue:7 Topics: Acute Kidney Injury; Animals; Calcium Channel Blockers; Dihydropyridines; Diuretics; Free Radical Scavengers; Free Radicals; Glycerol; Ischemia; Kidney; Lipid Peroxidation; Male; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Rats, Wistar	1994
Effects of long-term oral administration of NZ-105, a novel calcium antagonist, with or without propranolol in spontaneously hypertensive rats. The Journal of pharmacy and pharmacology, 1993, Volume: 45, Issue:6 Topics: Administration, Oral; Aldosterone; Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Dose-Response Relationship, Drug; Heart; Heart Rate; Hypertension; Kidney; Liver; Male; Nitrophenols; Organ Size; Organophosphorus Compounds; Propranolol; Rats; Rats, Inbred SHR; Renin; Time Factors	1993
[Effect of efonidipine hydrochloride (NZ-105), a new dihydropyridine calcium antagonist, on the experimental atherosclerosis in cholesterol-fed rabbits]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 103, Issue:5 Topics: Animals; Aorta; Aortic Diseases; Arteriosclerosis; Calcium; Cholesterol; Cholesterol, Dietary; Diet, Atherogenic; Dihydropyridines; Lipids; Nitrophenols; Organophosphorus Compounds; Rabbits	1994
Studies on the hypotensive mechanisms of NZ-105, a new dihydropyridine derivative, in rats and rabbits. General pharmacology, 1993, Volume: 24, Issue:2 Topics: Animals; Antihypertensive Agents; Blood Pressure; Decerebrate State; Dihydropyridines; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Posture; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar	1993
[Effect of efonidipine hydrochloride (NZ-105) on modification of low density lipoprotein induced by rat cultured endothelial cells]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1995, Volume: 106, Issue:4 Topics: Animals; Arteriosclerosis; Calcium Channel Blockers; Cells, Cultured; Depression, Chemical; Dihydropyridines; Dose-Response Relationship, Drug; Endothelium; Lipoproteins, LDL; Male; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Wistar	1995
Effects of efonidipine hydrochloride on cholesterol esterification mediated by beta-very low density lipoprotein in J774 macrophages. Japanese journal of pharmacology, 1995, Volume: 69, Issue:2 Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cholesterol; Cyclic AMP; Dihydropyridines; Dose-Response Relationship, Drug; Esterification; Lipoproteins, VLDL; Macrophages; Mice; Nicardipine; Nitrophenols; Organophosphorus Compounds; Radioligand Assay	1995
Identification of efonidipine hydrochloride metabolites in rats. Arzneimittel-Forschung, 1995, Volume: 45, Issue:7 Topics: Administration, Oral; Animals; Bile; Biotransformation; Calcium Channel Blockers; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dihydropyridines; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley	1995
Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem. General pharmacology, 1996, Volume: 27, Issue:3 Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Wistar; Verapamil	1996
[Effect of efonidipine hydrochloride on myocardial oxygen balance in anesthetized dogs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996, Volume: 108, Issue:2 Topics: Anesthesia; Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Female; Heart Rate; Male; Myocardium; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Thoracotomy	1996
Effects of efonidipine, nicardipine and captopril on proteinuria in aged spontaneously hypertensive rats. Arzneimittel-Forschung, 1996, Volume: 46, Issue:9 Topics: Aging; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Calcium Channel Blockers; Captopril; Creatinine; Dihydropyridines; Heart Rate; Hypertension; Kidney; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Proteinuria; Rats; Rats, Inbred SHR	1996
[Effect of efonidipine hydrochloride (NZ-105), a dihydropyridine derivative with calcium antagonistic action, on myocardial oxygen tension in anesthetized dogs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996, Volume: 108, Issue:5 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Circulation; Dihydropyridines; Dogs; Myocardium; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Partial Pressure	1996
Efonidipine, a long-acting dihydropyridine derivative, attenuates coronary vasoconstriction induced by endothelin-1 in dogs. Japanese journal of pharmacology, 1996, Volume: 72, Issue:4 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Coronary Angiography; Coronary Vessels; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Endothelin-1; Female; Heart Rate; Male; Nitrophenols; Organophosphorus Compounds; Vasodilation	1996
[Effects of efonidipine hydrochloride, a calcium antagonist derived from dihydropyridine, on acute myocardial ischemia in anesthetized open-chest dogs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1996, Volume: 108, Issue:6 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Dihydropyridines; Dogs; Female; Hemodynamics; Male; Myocardial Ischemia; Nitrophenols; Organophosphorus Compounds; Oxygen Consumption; Regional Blood Flow; Vascular Resistance	1996
Spasmolytic effect of efonidipine hydrochloride in isolated canine coronary artery: comparison with the effects of nifedipine and nisoldipine. Biological & pharmaceutical bulletin, 1997, Volume: 20, Issue:2 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 4-Aminopyridine; Amifampridine; Animals; Arteries; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Dogs; In Vitro Techniques; Nitrophenols; Organophosphorus Compounds; Potassium; Prostaglandin Endoperoxides, Synthetic; Thromboxane A2; Vasoconstrictor Agents	1997
Inhibitory effects of efonidipine hydrochloride on contraction induced by several vasoconstrictors in porcine coronary artery: comparison with effects of nifedipine and nisoldipine. Journal of cardiovascular pharmacology, 1997, Volume: 29, Issue:5 Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Binding, Competitive; Calcium Channel Blockers; Coronary Vessels; Dihydropyridines; Endothelin-1; In Vitro Techniques; Muscle Contraction; Muscle, Smooth, Vascular; Nifedipine; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Potassium; Prostaglandin Endoperoxides, Synthetic; Serotonin; Swine; Thromboxane A2; Vasoconstrictor Agents	1997
Effect of efonidipine, a novel dihydropyridine derivative, on myocardial metabolic changes induced by coronary artery ligation in dogs: comparison with nifedipine. Fundamental & clinical pharmacology, 1997, Volume: 11, Issue:3 Topics: Animals; Calcium Channel Blockers; Carbohydrate Metabolism; Dihydropyridines; Dogs; Energy Metabolism; Female; Hemodynamics; Male; Myocardial Ischemia; Myocardium; Nifedipine; Nitrophenols; Organophosphorus Compounds	1997
Effects of Ca2+ channel antagonists on sinus node: prolongation of late phase 4 depolarization by efonidipine. European journal of pharmacology, 1997, Sep-17, Volume: 335, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Male; Nitrophenols; Organophosphorus Compounds; Rabbits; Sinoatrial Node	1997
The voltage-dependent non-selective cation channel sensitive to the L-type calcium channel blocker efonidipine regulates Ca2+ influx in brain vascular smooth muscle cells. Biochemical and biophysical research communications, 1997, Nov-17, Volume: 240, Issue:2 Topics: Animals; Barium; Brain; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Carotid Arteries; Cattle; Cells, Cultured; Cerebral Arteries; Dihydropyridines; Membrane Potentials; Muscle, Smooth, Vascular; Nicardipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Time Factors	1997
Effects of the antihypertensive drug efonidipine hydrochloride on albuminuria and renal histopathology in young spontaneously hypertensive rats with diabetes. General pharmacology, 1998, Volume: 30, Issue:5 Topics: Albuminuria; Animals; Antihypertensive Agents; Diabetes Mellitus, Experimental; Dihydropyridines; Hypertension; Kidney; Male; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Streptozocin	1998
Renal protective effects of efonidipine in partially nephrectomized spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993), 1998, Volume: 20, Issue:3 Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Progression; Hypertension; Kidney; Male; Nephrectomy; Nitrophenols; Organophosphorus Compounds; Proteinuria; Rats; Rats, Inbred SHR; Systole	1998
Inhibition of myocardial L- and T-type Ca2+ currents by efonidipine: possible mechanism for its chronotropic effect. European journal of pharmacology, 1998, May-22, Volume: 349, Issue:2-3 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Depression, Chemical; Dihydropyridines; Female; Guinea Pigs; Heart; Heart Rate; Male; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Potassium Channels; Sinoatrial Node	1998
Renal effects of efonidipine hydrochloride, a new calcium antagonist, in spontaneously hypertensive rats with glomerular injury. Clinical and experimental pharmacology & physiology, 1999, Volume: 26, Issue:9 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Glomerular Filtration Rate; Kidney; Kidney Glomerulus; Kidney Tubules, Proximal; Male; Nitrophenols; Organophosphorus Compounds; Proteinuria; Rats; Rats, Inbred SHR; Renal Circulation	1999
Effects of the antihypertensive drug nifedipine on albuminuria and renal histopathology in young spontaneously hypertensive rats with diabetes. General pharmacology, 1999, Volume: 33, Issue:5 Topics: Albuminuria; Animals; Antihypertensive Agents; Creatinine; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Dihydropyridines; Kidney; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR; Time Factors; Vasodilator Agents	1999
Possible requirement of phosphonate moiety for efonidipine effects on the sino-atrial node action potential. Life sciences, 2000, Volume: 66, Issue:16 Topics: Action Potentials; Animals; Calcium Channel Blockers; Dihydropyridines; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Rabbits; Sinoatrial Node; Structure-Activity Relationship	2000
The effects of calcium channel blockers on nuclear factor kappa B activation in the mesangium cells. Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:5 Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Calcimycin; Calcium Channel Agonists; Calcium Channel Blockers; Calcium Channels, L-Type; Carcinogens; Cells, Cultured; Dihydropyridines; Gene Expression; Genes, Reporter; Glomerular Mesangium; Humans; Ionophores; Luciferases; NF-kappa B; Nifedipine; Nitrophenols; Organophosphorus Compounds; Tetradecanoylphorbol Acetate; Verapamil	2000
Calcium antagonist inhibits glomerular cell apoptosis and injuries of L-NAME exacerbated nephrosclerosis in SHR. Hypertension research : official journal of the Japanese Society of Hypertension, 2000, Volume: 23, Issue:6 Topics: Animals; Apoptosis; Calcium Channel Blockers; Cell Count; Dihydropyridines; Enzyme Inhibitors; Kidney Glomerulus; Nephrosclerosis; NG-Nitroarginine Methyl Ester; Nitrophenols; Organophosphorus Compounds; Proliferating Cell Nuclear Antigen; Rats; Rats, Inbred SHR	2000
Frequency-dependent blockade of T-type Ca2+ current by efonidipine in cardiomyocytes. Life sciences, 2000, Dec-08, Volume: 68, Issue:3 Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Electric Stimulation; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Membrane Potentials; Myocardium; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Ventricular Function	2000
Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis. Clinical science (London, England : 1979), 2001, Volume: 101, Issue:4 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Male; Mibefradil; Natriuresis; Nifedipine; Nitric Oxide; Nitrophenols; Organophosphorus Compounds; Prostaglandins; Renal Circulation	2001
Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo. Journal of hypertension, 2001, Volume: 19, Issue:11 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dogs; Hemodynamics; Mibefradil; Microcirculation; Nifedipine; Nitrophenols; Organophosphorus Compounds; Renal Circulation; Vasodilation	2001
Effects of efonidipine hydrochloride on renal arteriolar diameters in spontaneously hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2002, Volume: 25, Issue:5 Topics: Animals; Arterioles; Blood Pressure; Body Weight; Calcium Channel Blockers; Corrosion Casting; Dihydropyridines; Hypertension, Renal; Kidney Glomerulus; Male; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR; Renal Circulation	2002
Clinical efficacy of efonidipine hydrochloride, a T-type calcium channel inhibitor, on sympathetic activities. Circulation journal : official journal of the Japanese Circulation Society, 2003, Volume: 67, Issue:2 Topics: 3-Iodobenzylguanidine; Adult; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Electrocardiography; Female; Heart; Heart Rate; Hemodynamics; Humans; Hypertension; Iodine Radioisotopes; Male; Nitrophenols; Organophosphorus Compounds; Radionuclide Imaging; Spectrum Analysis; Sympathetic Nervous System; Tachycardia; Treatment Outcome	2003
A comparison between calcium channel blocking drugs with different potencies for T- and L-type channels in preventing atrial electrical remodeling. Journal of cardiovascular pharmacology, 2004, Volume: 44, Issue:3 Topics: Administration, Oral; Animals; Atrial Fibrillation; Atrioventricular Node; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiac Pacing, Artificial; Dihydropyridines; Dogs; Electrophysiology; Forecasting; Heart Atria; Japan; Male; Nitrophenols; Organophosphorus Compounds; Refractory Period, Electrophysiological; Research Design; Time Factors; Verapamil	2004
Identification of R(-)-isomer of efonidipine as a selective blocker of T-type Ca2+ channels. British journal of pharmacology, 2004, Volume: 143, Issue:8 Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Cell Line; Cricetinae; Dihydropyridines; Dose-Response Relationship, Drug; Female; Nitrophenols; Organophosphorus Compounds; Stereoisomerism; Xenopus	2004
The R(-)-enantiomer of efonidipine blocks T-type but not L-type calcium current in guinea pig ventricular myocardium. Journal of pharmacological sciences, 2004, Volume: 96, Issue:4 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Guinea Pigs; Heart; Heart Ventricles; Nitrophenols; Organophosphorus Compounds; Stereoisomerism	2004
Divergent action of calcium channel blockers on ATP-binding cassette protein expression. Journal of cardiovascular pharmacology, 2005, Volume: 46, Issue:6 Topics: Atherosclerosis; ATP Binding Cassette Transporter 1; ATP-Binding Cassette Transporters; Calcium Channel Blockers; Cells, Cultured; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dihydropyridines; Humans; Hypertension; Janus Kinase 2; Nitrophenols; Organophosphorus Compounds; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; RNA, Messenger	2005
Inhibitory effect of efonidipine on aldosterone synthesis and secretion in human adrenocarcinoma (H295R) cells. Journal of cardiovascular pharmacology, 2006, Volume: 47, Issue:1 Topics: Adrenal Gland Neoplasms; Aldosterone; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line, Tumor; Cytochrome P-450 CYP11B2; Dihydropyridines; Humans; Nitrophenols; Organophosphorus Compounds; RNA, Messenger	2006
Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms. Pharmacology, 2006, Volume: 78, Issue:1 Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Humans; Mibefradil; Nifedipine; Nitrophenols; Organophosphorus Compounds; Recombinant Proteins	2006
Effects of benidipine in a rat model for experimental angina. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 2006, Volume: 126, Issue:12 Topics: Amlodipine; Angina Pectoris; Animals; Blood Pressure; Calcium Channel Blockers; Dihydropyridines; Disease Models, Animal; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred Strains	2006
Beneficial effects of the dual L- and T-type Ca2+ channel blocker efonidipine on cardiomyopathic hamsters. Circulation journal : official journal of the Japanese Circulation Society, 2007, Volume: 71, Issue:12 Topics: Animals; Blood Pressure; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiomyopathies; Cricetinae; Dihydropyridines; Disease Models, Animal; Dose-Response Relationship, Drug; Electrophysiology; Female; Heart Rate; Male; Mesocricetus; Myocytes, Cardiac; Natriuretic Peptide, Brain; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques	2007
T-type calcium channel blockade as a therapeutic strategy against renal injury in rats with subtotal nephrectomy. Kidney international, 2008, Volume: 73, Issue:7 Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Chronic Disease; Dihydropyridines; Hypertension; Kidney Diseases; Male; Nephrectomy; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Inbred SHR	2008
T-type Ca2+ channel blockers prevent cardiac cell hypertrophy through an inhibition of calcineurin-NFAT3 activation as well as L-type Ca2+ channel blockers. Life sciences, 2008, Mar-12, Volume: 82, Issue:11-12 Topics: Active Transport, Cell Nucleus; Animals; Calcineurin; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cattle; Cells, Cultured; Dihydropyridines; Hypertrophy; Mice; Myocardium; Myocytes, Cardiac; Natriuretic Peptide, Brain; Neurotoxins; NFATC Transcription Factors; Nisoldipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Scorpion Venoms	2008
A selective T-type Ca2+ channel blocker R(-) efonidipine. Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 377, Issue:4-6 Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, T-Type; Dihydropyridines; Dose-Response Relationship, Drug; Flunarizine; Mibefradil; Nitrophenols; Nystatin; Organophosphorus Compounds; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Pyramidal Cells; Rats; Rats, Wistar; Sodium Channels	2008
Species difference in the contribution of T-type calcium current to cardiac pacemaking as revealed by r(-)-efonidipine. Journal of pharmacological sciences, 2008, Volume: 107, Issue:1 Topics: Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Guinea Pigs; Heart Atria; Heart Rate; In Vitro Techniques; Mice; Microelectrodes; Nitrophenols; Organophosphorus Compounds; Rabbits; Sinoatrial Node; Species Specificity; Time Factors	2008
Spectroscopic studies on the interaction of efonidipine with bovine serum albumin. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 2008, Volume: 41, Issue:7 Topics: Animals; Cattle; Circular Dichroism; Dihydropyridines; Models, Chemical; Nitrophenols; Organophosphorus Compounds; Serum Albumin, Bovine; Spectrometry, Fluorescence; Thermodynamics	2008
Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs. The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:2 Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Dihydropyridines; Humans; Mibefradil; Nitrophenols; Organophosphorus Compounds; Verapamil	2009
Azelnidipine inhibits aldosterone synthesis and secretion in human adrenocortical cell line NCI-H295R. European journal of pharmacology, 2009, Mar-01, Volume: 605, Issue:1-3 Topics: Adrenal Cortex Neoplasms; Adrenocortical Carcinoma; Aldosterone; Angiotensin II; Azetidinecarboxylic Acid; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cell Line, Tumor; Cytochrome P-450 CYP11B2; Dihydropyridines; Gene Expression Regulation; Humans; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Steroid 11-beta-Hydroxylase	2009
Effects of efonidipine hydrochloride on heart rate and circulatory changes due to stress. Clinical and experimental hypertension (New York, N.Y. : 1993), 2009, Volume: 31, Issue:1 Topics: Adult; Blood Pressure; Calcium Channel Blockers; Cardiotonic Agents; Dihydropyridines; Heart Rate; Humans; Male; Nitrophenols; Organophosphorus Compounds; Stress, Physiological; Stress, Psychological	2009
Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade. Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:4 Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Mibefradil; Microvessels; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Sprague-Dawley; Subcutaneous Fat; Vasoconstriction; Verapamil	2009
T-type Ca2+ channels promote oxygenation-induced closure of the rat ductus arteriosus not only by vasoconstriction but also by neointima formation. The Journal of biological chemistry, 2009, Sep-04, Volume: 284, Issue:36 Topics: Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Ductus Arteriosus; Muscle, Smooth, Vascular; Nitrophenols; Organ Culture Techniques; Organophosphorus Compounds; Protein Isoforms; Rats; Rats, Wistar; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP4 Subtype; Vasoconstriction	2009
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure. Circulation, 2009, Sep-01, Volume: 120, Issue:9 Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiomyopathy, Dilated; Death, Sudden, Cardiac; Dihydropyridines; Disease Models, Animal; Female; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Infarction; Myocytes, Cardiac; Nitrendipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques	2009
Effects of enfonidipine hydrochloride in dogs with experimental supraventricular tachyarrhythmia. The Journal of veterinary medical science, 2010, Volume: 72, Issue:7 Topics: Animals; Antihypertensive Agents; Calcium Channel Blockers; Dihydropyridines; Dog Diseases; Dogs; Heart Rate; Humans; Nitrophenols; Organophosphorus Compounds; Systole; Tachycardia; Tachycardia, Supraventricular; Treatment Outcome	2010
Regulation of adrenal aldosterone production by serine protease prostasin. Journal of biomedicine & biotechnology, 2010, Volume: 2010 Topics: Adrenal Cortex; Aldosterone; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Channel Blockers; Cell Line; Cytochrome P-450 CYP11B2; Dihydropyridines; Gene Expression Regulation; Gene Silencing; Humans; Nitrophenols; Organophosphorus Compounds; Promoter Regions, Genetic; Rats; Receptors, Proteinase-Activated; Recombinant Proteins; Serine Endopeptidases; Tetrazoles; Transfection; Valine; Valsartan	2010
Combination therapy with irbesartan and efonidipine for attenuation of proteinuria in Dahl salt-sensitive rats. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:9 Topics: Amlodipine; Angiotensin II Type 1 Receptor Blockers; Animals; Biphenyl Compounds; Blood Pressure; Calcium Channel Blockers; Chemokine CCL2; Collagen Type I; Dihydropyridines; Drug Therapy, Combination; Gene Expression; Glomerulosclerosis, Focal Segmental; Hypertension; Irbesartan; Kidney Glomerulus; Male; NADPH Oxidases; Nitrophenols; Organophosphorus Compounds; Proteinuria; Rats; Rats, Inbred Dahl; Tetrazoles; Transforming Growth Factor beta	2010
Comparison of strict- and mild-blood pressure control in elderly hypertensive patients: a per-protocol analysis of JATOS. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:11 Topics: Aged; Aged, 80 and over; Antihypertensive Agents; Blood Pressure; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Incidence; Japan; Male; Nitrophenols; Organophosphorus Compounds; Randomized Controlled Trials as Topic; Treatment Outcome	2010
Efonidipine improves renal function and decreases proteinuria in elderly hypertensive patients in the JATOS study. Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:11 Topics: Aged; Antihypertensive Agents; Chronic Disease; Dihydropyridines; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Diseases; Nitrophenols; Organophosphorus Compounds; Proteinuria; Randomized Controlled Trials as Topic	2010
Effects of S(+)-efonidipine on the rabbit sinus node action potential and calcium channel subunits Ca(V)1.2, Ca(V)1.3 and Ca(V)3.1. European journal of pharmacology, 2010, Dec-15, Volume: 649, Issue:1-3 Topics: Action Potentials; Animals; Antihypertensive Agents; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Cricetinae; Depression, Chemical; Dihydropyridines; Heart Rate; In Vitro Techniques; Isomerism; Kinetics; Male; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques; Protein Isoforms; Protein Subunits; Rabbits; Recombinant Proteins; Sinoatrial Node	2010
Is renal antiaging possible? Hypertension research : official journal of the Japanese Society of Hypertension, 2010, Volume: 33, Issue:11 Topics: Aging; Antihypertensive Agents; Chronic Disease; Dihydropyridines; Glomerular Filtration Rate; Humans; Hypertension; Kidney; Kidney Diseases; Nitrophenols; Organophosphorus Compounds; Randomized Controlled Trials as Topic	2010
Inhibitory effects of T/L-type calcium channel blockers on tubulointerstitial fibrosis in obstructed kidneys in rats. Urology, 2011, Volume: 77, Issue:1 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Fibrosis; Kidney Tubules; Male; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Ureteral Obstruction	2011
Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease. The Journal of clinical investigation, 2011, Volume: 121, Issue:8 Topics: Animals; Benzimidazoles; Cadmium; Calcium; Calcium Channels, T-Type; Cyclopropanes; Dihydropyridines; Disease Models, Animal; Electrophysiology; Male; Mibefradil; Movement; Naphthalenes; Neurons; Nickel; Nitrophenols; Organophosphorus Compounds; Parkinson Disease; Rats; Rats, Wistar	2011
Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells. The Tohoku journal of experimental medicine, 2011, Volume: 224, Issue:4 Topics: Adrenocortical Carcinoma; Angiotensin II; Bucladesine; Calcium Channel Blockers; Cell Line, Tumor; Dehydroepiandrosterone Sulfate; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydrocortisone; Nitrophenols; Organophosphorus Compounds; Phosphoproteins; RNA, Messenger; Verapamil	2011
Effect of efonidipine on TGF-β1-induced cardiac fibrosis through Smad2-dependent pathway in rat cardiac fibroblasts. Journal of pharmacological sciences, 2011, Volume: 117, Issue:2 Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Fibroblasts; Fibrosis; Myocardium; Nifedipine; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Smad2 Protein; Transfection; Transforming Growth Factor beta1	2011
Is metabolic syndrome a risk factor for cardiovascular disease in late elderly? American journal of hypertension, 2011, Volume: 24, Issue:11 Topics: Blood Pressure; Cardiovascular Diseases; Dihydropyridines; Female; Humans; Hypertension; Male; Metabolic Syndrome; Nitrophenols; Organophosphorus Compounds	2011
Effects of efonidipine on the pharmacokinetics and pharmacodynamics of repaglinide: possible role of CYP3A4 and P-glycoprotein inhibition by efonidipine. Journal of pharmacokinetics and pharmacodynamics, 2012, Volume: 39, Issue:1 Topics: Animals; Antihypertensive Agents; Area Under Curve; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biocatalysis; Biological Availability; Blood Glucose; Carbamates; Cell Line, Tumor; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dihydropyridines; Drug Interactions; Humans; Hypoglycemic Agents; Ketoconazole; Male; Models, Biological; Nitrophenols; Organophosphorus Compounds; Pharmacological Phenomena; Piperidines; Rats; Rats, Sprague-Dawley; Rhodamine 123	2012
T-type calcium channel blockade improves survival and cardiovascular function in thalassemic mice. European journal of haematology, 2012, Volume: 88, Issue:6 Topics: Animals; Azoles; Base Sequence; beta-Thalassemia; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiovascular System; Deferoxamine; Dihydropyridines; Disease Models, Animal; DNA Primers; Heart Rate; Humans; Iron; Iron Chelating Agents; Iron, Dietary; Isoindoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Nifedipine; Nitrophenols; Organ Size; Organophosphorus Compounds; Organoselenium Compounds; RNA, Messenger; Ventricular Function, Left; Verapamil	2012
Role of specific T-type calcium channel blocker R(-) efonidipine in the regulation of renal medullary circulation. Journal of hypertension, 2012, Volume: 30, Issue:8 Topics: Angiotensin II; Animals; Blood Flow Velocity; Calcium Channel Blockers; Calcium Channels, T-Type; Dihydropyridines; Disease Models, Animal; Drug Antagonism; Infusions, Intravenous; Ischemia; Kidney Medulla; Laser-Doppler Flowmetry; NG-Nitroarginine Methyl Ester; Nitrogen Dioxide; Nitrogen Oxides; Nitrophenols; Organophosphorus Compounds; Rats; Rats, Sprague-Dawley; Renal Circulation; Vasoconstrictor Agents	2012
Ferric iron uptake into cardiomyocytes of β-thalassemic mice is not through calcium channels. Drug and chemical toxicology, 2013, Volume: 36, Issue:3 Topics: Animals; Azoles; beta-Thalassemia; Calcium Channel Blockers; Calcium Channels; Calcium Channels, L-Type; Calcium Channels, T-Type; Cation Transport Proteins; Cell Survival; Cells, Cultured; Deferoxamine; Dihydropyridines; Disease Models, Animal; Ferric Compounds; Heart Ventricles; Iron Overload; Isoindoles; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocytes, Cardiac; Nitrophenols; Organophosphorus Compounds; Organoselenium Compounds; Quaternary Ammonium Compounds; Receptors, Transferrin; Verapamil	2013
A molecular signature of tissues with pacemaker activity in the heart and upper urinary tract involves coexpressed hyperpolarization-activated cation and T-type Ca2+ channels. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2014, Volume: 28, Issue:2 Topics: Animals; Dihydropyridines; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Immunohistochemistry; Kidney; Mice; Muscle Contraction; Muscle, Smooth; Nitrophenols; Organophosphorus Compounds; Peristalsis; Urinary Tract	2014
Determination of efonidipine in human plasma by LC-MS/MS for pharmacokinetic applications. Journal of pharmaceutical and biomedical analysis, 2015, Jan-25, Volume: 103 Topics: Adult; Calcium Channel Blockers; Chromatography, Liquid; Dihydropyridines; Female; Humans; Limit of Detection; Male; Nitrophenols; Organophosphorus Compounds; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Young Adult	2015
Dual T-type and L-type calcium channel blocker exerts beneficial effects in attenuating cardiovascular dysfunction in iron-overloaded thalassaemic mice. Experimental physiology, 2016, Volume: 101, Issue:4 Topics: Animals; Benzoates; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiovascular Diseases; Deferasirox; Deferiprone; Deferoxamine; Dihydropyridines; Heart; Iron Chelating Agents; Iron Overload; Male; Malondialdehyde; Mice; Mice, Inbred C57BL; Mitochondria; Nitrophenols; Organophosphorus Compounds; Pyridones; Thalassemia; Triazoles	2016
A chiral LC-MS/MS method for the stereospecific determination of efonidipine in human plasma. Journal of pharmaceutical and biomedical analysis, 2016, Apr-15, Volume: 122 Topics: Administration, Oral; Chromatography, Liquid; Dihydropyridines; Humans; Liquid-Liquid Extraction; Nitrophenols; Organophosphorus Compounds; Plasma; Stereoisomerism; Tablets; Tandem Mass Spectrometry	2016
Solid dispersions of efonidipine hydrochloride ethanolate with improved physicochemical and pharmacokinetic properties prepared with microwave treatment. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2016, Volume: 108 Topics: Animals; Area Under Curve; Calorimetry, Differential Scanning; Dihydropyridines; Dogs; Drug Carriers; Hot Temperature; Magnetic Resonance Spectroscopy; Male; Methylcellulose; Microwaves; Nitrophenols; Organic Chemicals; Organophosphorus Compounds; Solubility; Solvents; Urea; X-Ray Diffraction	2016
Effects of iron overload, an iron chelator and a T-Type calcium channel blocker on cardiac mitochondrial biogenesis and mitochondrial dynamics in thalassemic mice. European journal of pharmacology, 2017, Mar-15, Volume: 799 Topics: Aminophylline; Animals; Apoptosis; Atropine; Blood Pressure; Calcium Channel Blockers; Calcium Channels, T-Type; Deferiprone; Dihydropyridines; Drug Combinations; Heart; Heart Rate; Iron; Iron Chelating Agents; Iron Overload; Male; Malondialdehyde; Mice; Mitochondria; Myocardium; Nitroglycerin; Nitrophenols; Organelle Biogenesis; Organophosphorus Compounds; Oxidative Phosphorylation; Papaverine; Phenobarbital; Pyridones; Signal Transduction; Thalassemia	2017
Increased bioavailability of efonidipine hydrochloride nanosuspensions by the wet-milling method. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V, 2018, Volume: 130 Topics: Animals; Area Under Curve; Arginine; Biological Availability; Calcium Channel Blockers; Chemistry, Pharmaceutical; Dihydropyridines; Excipients; Hydrogen-Ion Concentration; Male; Nanoparticles; Nitrophenols; Organophosphorus Compounds; Poloxamer; Rats; Rats, Sprague-Dawley; Sodium Dodecyl Sulfate; Solubility; Suspensions; Tablets	2018
Structural basis for efonidipine block of a voltage-gated Ca Biochemical and biophysical research communications, 2019, 06-04, Volume: 513, Issue:3 Topics: Arcobacter; Calcium Channel Blockers; Calcium Channels; Crystallography, X-Ray; Dihydropyridines; Humans; Models, Molecular; Nitrophenols; Organophosphorus Compounds; Protein Conformation	2019
Deferiprone and efonidipine mitigated iron-overload induced neurotoxicity in wild-type and thalassemic mice. Life sciences, 2019, Dec-15, Volume: 239 Topics: Animals; Calcium Channel Blockers; Calcium Channels, T-Type; Deferiprone; Dihydropyridines; Disease Models, Animal; Iron; Iron Chelating Agents; Iron Overload; Mice; Mice, Inbred C57BL; Neurotoxicity Syndromes; Nitrophenols; Organophosphorus Compounds; Thalassemia	2019
Role Of Efonidipine In CKD Patients : A Study in North Bihar. The Journal of the Association of Physicians of India, 2020, Volume: 68, Issue:1 Topics: Dihydropyridines; Humans; Nitrophenols; Organophosphorus Compounds; Renal Insufficiency, Chronic	2020
In Vitro-In Vivo Correlation for Solid Dispersion of a Poorly Water-Soluble Drug Efonidipine Hydrochloride. AAPS PharmSciTech, 2020, May-31, Volume: 21, Issue:5 Topics: Animals; Calcium Channel Blockers; Dihydropyridines; In Vitro Techniques; Male; Nitrophenols; Organophosphorus Compounds; Pharmaceutical Preparations; Rats; Rats, Sprague-Dawley; Solubility; Solvents; Water	2020
Zonisamide can ameliorate the voltage-dependence alteration of the T-type calcium channel Ca Molecular brain, 2020, 11-26, Volume: 13, Issue:1 Topics: Calcium Channels, T-Type; Dihydropyridines; Electrophysiological Phenomena; HEK293 Cells; Humans; Mutation; Nitrophenols; Organophosphorus Compounds; Spinocerebellar Ataxias; Zonisamide	2020
Is PF-00835231 a Pan-SARS-CoV-2 Mpro Inhibitor? A Comparative Study. Molecules (Basel, Switzerland), 2021, Mar-17, Volume: 26, Issue:6 Topics: Antiviral Agents; Binding Sites; Computer Simulation; Coronavirus 3C Proteases; COVID-19 Drug Treatment; Databases, Protein; Diarylquinolines; Dihydropyridines; Humans; Indoles; Leucine; Ligands; Molecular Docking Simulation; Molecular Dynamics Simulation; Nitrobenzenes; Nitrophenols; Organophosphorus Compounds; Piperazines; Proline; Protease Inhibitors; Pyrrolidinones; SARS-CoV-2	2021
Efonidipine Exerts Cerebroprotective Effect by Down-regulation of TGF-β/SMAD-2-Dependent Signaling Pathway in Diabetic Rats. Journal of molecular neuroscience : MN, 2021, Volume: 71, Issue:9 Topics: Acetylcholinesterase; Animals; Brain; Calcium Channel Blockers; Diabetes Mellitus, Experimental; Dihydropyridines; Infarction, Middle Cerebral Artery; Male; Malondialdehyde; Neuroprotective Agents; Nitrites; Nitrophenols; Organophosphorus Compounds; Oxidative Stress; Rats; Rats, Sprague-Dawley; Signal Transduction; Smad2 Protein; Transforming Growth Factor beta; Vascular Endothelial Growth Factor A	2021