Compounds > efonidipine
Page last updated: 2024-09-03

efonidipine and mibefradil

efonidipine has been researched along with mibefradil in 9 studies

Compound Research Comparison

Studies
(efonidipine)		Trials
(efonidipine)		Recent Studies (post-2010)
(efonidipine)		Studies
(mibefradil)		Trials
(mibefradil)		Recent Studies (post-2010) (mibefradil)
129183066769143

Protein Interaction Comparison

ProteinTaxonomyefonidipine (IC50)mibefradil (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.156
Voltage-dependent T-type calcium channel subunit alpha-1GHomo sapiens (human)1.0476
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.333
Voltage-dependent T-type calcium channel subunit alpha-1HHomo sapiens (human)0.4122
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.5
ATP-dependent translocase ABCB1Mus musculus (house mouse)10
ATP-dependent translocase ABCB1Homo sapiens (human)1.58
Cytochrome P450 3A4Homo sapiens (human)0.2575
Cytochrome P450 2D6Homo sapiens (human)0.063
Cytochrome P450 2C9 Homo sapiens (human)2.14
Sodium channel protein type 4 subunit alphaRattus norvegicus (Norway rat)0.5
5-hydroxytryptamine receptor 1ARattus norvegicus (Norway rat)1.34
ATP-dependent translocase ABCB1Mus musculus (house mouse)7.4
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.98
Cytochrome P450 2J2Homo sapiens (human)2.14
Voltage-dependent L-type calcium channel subunit beta-3Rattus norvegicus (Norway rat)1
Voltage-dependent N-type calcium channel subunit alpha-1BHomo sapiens (human)0.878
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.98
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.333
Voltage-dependent N-type calcium channel subunit alpha-1BRattus norvegicus (Norway rat)1
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.4543
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.333
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.2795
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.74
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.98
Voltage-dependent T-type calcium channel subunit alpha-1IHomo sapiens (human)0.4187
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.98
Sodium channel protein type 10 subunit alphaHomo sapiens (human)0.98

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (88.89)29.6817
2010's1 (11.11)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Hayashi, K; Honda, M; Kubota, E; Matsuda, H; Okubo, K; Ozawa, Y; Saruta, T; Tokuyama, H1
Hayashi, K; Honda, M; Kubota, E; Matsuda, H; Okubo, K; Ozawa, Y; Saruta, T; Takamatsu, I; Tokuyama, H1
Shigenobu, K; Tanaka, H1
Hadama, T; Kaku, T; Lee, TS; Miyamoto, S; Ono, K; Perez-Reyes, E; Takebayashi, S; Uchino, T1
Akaike, N; Kim, CJ; Min, BI; Ogawa, S; Shin, MC; Tanaka, E1
Perez-Reyes, E; Van Deusen, AL; Vitko, I1
Ball, CJ; Beltrame, JF; Saint, DA; Turner, SP; Wilson, DP1
Arai, Y; Fujiwara, M; Harada, M; Kinoshita, H; Kuwabara, Y; Kuwahara, K; Murakami, M; Nakagawa, Y; Nakanishi, M; Nakao, K; Takano, M; Ueshima, K; Yasuno, S1
Huang, CS; Kuo, CC; Pan, MK; Tai, CH; Yang, YC1

Reviews

1 review(s) available for efonidipine and mibefradil

ArticleYear
Pathophysiological significance of T-type Ca2+ channels: T-type Ca2+ channels and drug development.
    Journal of pharmacological sciences, 2005, Volume: 99, Issue:3

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Drug Design; Humans; Mibefradil; Nitrophenols; Organophosphorus Compounds

2005

Other Studies

8 other study(ies) available for efonidipine and mibefradil

ArticleYear
Divergent natriuretic action of calcium channel antagonists in mongrel dogs: renal haemodynamics as a determinant of natriuresis.
    Clinical science (London, England : 1979), 2001, Volume: 101, Issue:4

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dogs; Dose-Response Relationship, Drug; Hemodynamics; Male; Mibefradil; Natriuresis; Nifedipine; Nitric Oxide; Nitrophenols; Organophosphorus Compounds; Prostaglandins; Renal Circulation

2001
Divergent renal vasodilator action of L- and T-type calcium antagonists in vivo.
    Journal of hypertension, 2001, Volume: 19, Issue:11

    Topics: Animals; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Dogs; Hemodynamics; Mibefradil; Microcirculation; Nifedipine; Nitrophenols; Organophosphorus Compounds; Renal Circulation; Vasodilation

2001
Actions of mibefradil, efonidipine and nifedipine block of recombinant T- and L-type Ca channels with distinct inhibitory mechanisms.
    Pharmacology, 2006, Volume: 78, Issue:1

    Topics: Calcium Channel Blockers; Calcium Channels, L-Type; Cell Line; Dihydropyridines; Humans; Mibefradil; Nifedipine; Nitrophenols; Organophosphorus Compounds; Recombinant Proteins

2006
A selective T-type Ca2+ channel blocker R(-) efonidipine.
    Naunyn-Schmiedeberg's archives of pharmacology, 2008, Volume: 377, Issue:4-6

    Topics: Animals; Barium; Calcium; Calcium Channel Blockers; Calcium Channels; Calcium Channels, T-Type; Dihydropyridines; Dose-Response Relationship, Drug; Flunarizine; Mibefradil; Nitrophenols; Nystatin; Organophosphorus Compounds; Patch-Clamp Techniques; Potassium Channels, Calcium-Activated; Pyramidal Cells; Rats; Rats, Wistar; Sodium Channels

2008
Molecular pharmacology of human Cav3.2 T-type Ca2+ channels: block by antihypertensives, antiarrhythmics, and their analogs.
    The Journal of pharmacology and experimental therapeutics, 2009, Volume: 328, Issue:2

    Topics: Anti-Arrhythmia Agents; Antihypertensive Agents; Calcium; Calcium Channel Blockers; Calcium Channels, T-Type; Cells, Cultured; Dihydropyridines; Humans; Mibefradil; Nitrophenols; Organophosphorus Compounds; Verapamil

2009
Heterogeneity of L- and T-channels in the vasculature: rationale for the efficacy of combined L- and T-blockade.
    Hypertension (Dallas, Tex. : 1979), 2009, Volume: 53, Issue:4

    Topics: Animals; Aorta; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Dihydropyridines; Humans; Hypertension; In Vitro Techniques; Male; Mesenteric Arteries; Mibefradil; Microvessels; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Sprague-Dawley; Subcutaneous Fat; Vasoconstriction; Verapamil

2009
T-type Ca2+ channel blockade prevents sudden death in mice with heart failure.
    Circulation, 2009, Sep-01, Volume: 120, Issue:9

    Topics: Animals; Arrhythmias, Cardiac; Autonomic Nervous System; Blood Pressure; Body Weight; Calcium Channel Blockers; Calcium Channels, L-Type; Calcium Channels, T-Type; Cardiomyopathy, Dilated; Death, Sudden, Cardiac; Dihydropyridines; Disease Models, Animal; Female; Mibefradil; Mice; Mice, Inbred C57BL; Mice, Transgenic; Myocardial Infarction; Myocytes, Cardiac; Nitrendipine; Nitrophenols; Organophosphorus Compounds; Patch-Clamp Techniques

2009
Modulation of subthalamic T-type Ca(2+) channels remedies locomotor deficits in a rat model of Parkinson disease.
    The Journal of clinical investigation, 2011, Volume: 121, Issue:8

    Topics: Animals; Benzimidazoles; Cadmium; Calcium; Calcium Channels, T-Type; Cyclopropanes; Dihydropyridines; Disease Models, Animal; Electrophysiology; Male; Mibefradil; Movement; Naphthalenes; Neurons; Nickel; Nitrophenols; Organophosphorus Compounds; Parkinson Disease; Rats; Rats, Wistar

2011