Compounds > efonidipine
Page last updated: 2024-09-03

efonidipine and diltiazem

efonidipine has been researched along with diltiazem in 4 studies

Compound Research Comparison

Studies
(efonidipine)		Trials
(efonidipine)		Recent Studies (post-2010)
(efonidipine)		Studies
(diltiazem)		Trials
(diltiazem)		Recent Studies (post-2010) (diltiazem)
12918306,4021,073578

Protein Interaction Comparison

ProteinTaxonomyefonidipine (IC50)diltiazem (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1CCavia porcellus (domestic guinea pig)0.45
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.605
Cytochrome P450 3A4Homo sapiens (human)1.8366
Voltage-dependent L-type calcium channel subunit alpha-1CRattus norvegicus (Norway rat)0.896
Voltage-dependent L-type calcium channel subunit alpha-1DRattus norvegicus (Norway rat)0.896
Sodium channel protein type 1 subunit alphaHomo sapiens (human)9
Sodium channel protein type 4 subunit alphaHomo sapiens (human)9
Sodium channel protein type 7 subunit alphaHomo sapiens (human)9
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.605
Voltage-dependent L-type calcium channel subunit alpha-1SRattus norvegicus (Norway rat)0.896
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.605
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)0.605
Sodium channel protein type 5 subunit alphaHomo sapiens (human)9
Sodium channel protein type 9 subunit alphaHomo sapiens (human)9
Sodium channel protein type 2 subunit alphaHomo sapiens (human)9
Sodium channel protein type 3 subunit alphaHomo sapiens (human)9
Sodium channel protein type 11 subunit alphaHomo sapiens (human)9
Sodium channel protein type 8 subunit alphaHomo sapiens (human)9
Sodium channel protein type 10 subunit alphaHomo sapiens (human)9

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (50.00)18.2507
2000's1 (25.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Horinouchi, M; Komada, F; Nishiguchi, K; Ohmoto, N; Ohnishi, N; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y; Yokoyama, T1
Kobayashi, M; Niwa, M; Nozaki, M; Tsurumi, K1
Masumiya, H; Saito, W; Sekine, T; Shigenobu, K; Sijuku, T; Sugahara, M; Tanaka, H; Taniguchi, H; Terada, M1
Ikeda, K; Saito, T; Tojo, K1

Other Studies

4 other study(ies) available for efonidipine and diltiazem

ArticleYear
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression.
    European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 2002, Volume: 16, Issue:3

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Calcium Channel Blockers; Cell Line; Digoxin; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Gene Expression; Humans; Nifedipine; Paclitaxel; RNA, Messenger; Swine; Tritium; Tumor Cells, Cultured; Verapamil; Vinblastine

2002
[Affinity of Z-105 to the 1,4-dihydropyridine type calcium channel and several other receptor bindings in the central nervous system].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1992, Volume: 100, Issue:1

    Topics: Animals; Calcium Channel Blockers; Dihydropyridines; Diltiazem; In Vitro Techniques; Male; Nicardipine; Nitrophenols; Organophosphorus Compounds; Radioligand Assay; Rats; Receptors, Neurotransmitter; Tritium

1992
Myocardial and vascular effects of efonidipine in vitro as compared with nifedipine, verapamil and diltiazem.
    General pharmacology, 1996, Volume: 27, Issue:3

    Topics: Animals; Aorta, Thoracic; Calcium Channel Blockers; Dihydropyridines; Diltiazem; Female; Guinea Pigs; Heart; Heart Rate; In Vitro Techniques; Male; Muscle Contraction; Muscle, Smooth, Vascular; Myocardial Contraction; Nifedipine; Nitrophenols; Organophosphorus Compounds; Potassium Chloride; Rats; Rats, Wistar; Verapamil

1996
Efonidipine, a Ca(2+)-channel blocker, enhances the production of dehydroepiandrosterone sulfate in NCI-H295R human adrenocortical carcinoma cells.
    The Tohoku journal of experimental medicine, 2011, Volume: 224, Issue:4

    Topics: Adrenocortical Carcinoma; Angiotensin II; Bucladesine; Calcium Channel Blockers; Cell Line, Tumor; Dehydroepiandrosterone Sulfate; Dihydropyridines; Diltiazem; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Humans; Hydrocortisone; Nitrophenols; Organophosphorus Compounds; Phosphoproteins; RNA, Messenger; Verapamil

2011