efaroxan has been researched along with idazoxan in 41 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (2.44) | 18.7374 |
| 1990's | 15 (36.59) | 18.2507 |
| 2000's | 14 (34.15) | 29.6817 |
| 2010's | 9 (21.95) | 24.3611 |
| 2020's | 2 (4.88) | 2.80 |
| Authors | Studies |
|---|---|
| Arrault, A; Guillaumet, G; Mérour, JY; Pfeiffer, B; Renard, P; Rettori, MC; Scalbert, E; Touzeau, F | 1 |
| Agbaba, D; Filipic, S; Nikolic, K | 1 |
| Agbaba, D; Azzali, E; Costantino, G; Glisic, S; Laurila, JM; Nikolic, K; Perovic, V; Pieroni, M; Radi, M; Scheinin, M; Srdic-Rajic, T; Tassini, S; Veljkovic, N; Vucicevic, J | 1 |
| Berridge, TL; Doxey, JC; Roach, AG; Smith, CF | 1 |
| Chan, SL; Morgan, NG; Stillings, MR | 1 |
| Hyde, NA; Nichols, JD; Sugden, K | 1 |
| Berdeu, D; Bertrand, G; Gross, R; Loubatières-Mariani, MM; Puech, R | 1 |
| Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Scarpello, KE | 1 |
| Brown, CA; Morgan, NG | 1 |
| Starke, K; Trendelenburg, AU; Wahl, CA | 1 |
| Chan, CK; Head, GA | 1 |
| Dunne, MJ; Hashmi, MN; Kane, C; Shepherd, RM; Squires, PE | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Mourtada, M; Piercy, V; Smith, SA | 1 |
| Cleale, RM; Hadcock, JR; Ingling, JM; Pausch, MH; Search, DJ | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, J | 1 |
| Martín-Ruiz, R; Pineda, J; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Chopin, P; Colpaert, FC; Marien, M | 1 |
| Debowski, T; Krzystanek, E; Krzystanek, M; Saczewski, F; Trzeciak, H | 1 |
| Elliott, J; Morgan, NG; Mourtada, M; Smith, SA | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, JC | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Dominiak, P; Häuser, W; Jungbluth, B; Raasch, W; Schäfer, U | 2 |
| Gao, H; Morgan, NG; Mourtada, M | 1 |
| Bleck, C; Jörns, A; Rustenbeck, I; Wienbergen, A | 1 |
| Cambridge, N; Robinson, ES | 1 |
| Honda, M; Kino, Y; Ono, H; Tanabe, M | 1 |
| Cardinaletti, C; Carrieri, A; Gentili, F; Ghelfi, F; Mattioli, L; Perfumi, M; Pigini, M; Vesprini, C | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
| Aglawe, MM; Chopde, CT; Kotagale, NR; Taksande, BG; Tripathi, SJ; Umekar, MJ | 1 |
| Caselli, G; Ferrari, F; Lanza, M; Menghetti, I; Tremolada, D | 1 |
| García-Sevilla, JA; Keller, B | 2 |
| Boblewski, K; Kornicka, A; Lehmann, A; Marchwińska, A; Rybczyńska, A; Sączewski, F; Sączewski, J | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M; Yamazato, Y | 1 |
| Bernard, R; Bernstein, HG; Laube, G; Veh, RW; Weiss, T | 1 |
| Aglawe, MM; Chopde, CT; Gujar, S; Khade, SD; Kotagale, NR; Taksande, BG | 1 |
| Djikic, T; Laurila, J; Nikolic, K; Radi, M; Veljkovic, N; Vucicevic, J; Xhaard, H | 1 |
| Manole, OM; Moraru, C; Nechita, P; Rusu-Zota, G; Şorodoc, V | 1 |
1 review(s) available for efaroxan and idazoxan
| Article | Year |
|---|---|
Desensitization of insulin secretion by depolarizing insulin secretagogues.
Topics: Animals; Benzofurans; Calcium; Humans; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Potassium Channels | 2004 |
40 other study(ies) available for efaroxan and idazoxan
| Article | Year |
|---|---|
Synthesis and biological evaluation of new 2-(4,5-dihydro-1H-imidazol-2-yl)-3,4-dihydro-2H-1,4-benzoxazine derivatives.
Topics: Adrenal Medulla; Animals; Antihypertensive Agents; Binding Sites; Blood Pressure; Cattle; Frontal Lobe; Heart Rate; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Kidney; Oxazines; Rabbits; Radioligand Assay; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Receptors, Drug; Stereoisomerism; Structure-Activity Relationship | 2003 |
QSAR study of imidazoline antihypertensive drugs.
Topics: Antihypertensive Agents; Binding Sites; Imidazoline Receptors; Imidazolines; Ligands; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship | 2008 |
A combined ligand- and structure-based approach for the identification of rilmenidine-derived compounds which synergize the antitumor effects of doxorubicin.
Topics: Adrenergic alpha-Agonists; Antibiotics, Antineoplastic; Apoptosis; Doxorubicin; Drug Synergism; Humans; K562 Cells; Ligands; Molecular Structure; Oxazoles; Receptors, Adrenergic, alpha-2; Rilmenidine | 2016 |
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1992 |
Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Dioxanes; Dose-Response Relationship, Drug; Hypoglycemic Agents; Idazoxan; Imidazoles; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Phentolamine; Rats; Rats, Inbred Strains | 1991 |
Determination of underivatised efaroxan and idazoxan in blood plasma by capillary gas chromatography with mass-selective detection.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Dioxanes; Dioxins; Gas Chromatography-Mass Spectrometry; Humans; Idazoxan; Imidazoles | 1989 |
Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antazoline; Benzofurans; Binding, Competitive; Cimetidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptors, Drug; Reference Standards; Tolbutamide; Vascular Resistance | 1995 |
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels; Animals; Benzofurans; Binding, Competitive; Clonidine; Clorgyline; Diazoxide; Dioxanes; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulinoma; Ligands; Pancreatic Neoplasms; Potassium Channels; Rats; Receptors, Drug; Regression Analysis; Software; Tumor Cells, Cultured | 1994 |
The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites.
Topics: Animals; Benzofurans; Binding Sites; Dioxanes; Down-Regulation; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Male; Rats; Rats, Wistar; Receptors, Drug | 1994 |
Control of insulin secretion by imidazolines in rat pancreatic islets.
Topics: Animals; Benzofurans; Diazoxide; Dioxanes; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Rats | 1993 |
Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Benzofurans; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Imidazoles; Isotope Labeling; Male; Norepinephrine; Oxathiins; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tritium | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Calcium; Cytosol; Down-Regulation; Glucose; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Islets of Langerhans; Mice; Phentolamine; Receptors, Drug; Signal Transduction | 1996 |
Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Drug Interactions; Glyburide; Hypoglycemic Agents; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Stereoisomerism | 1997 |
Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Area Under Curve; Benzofurans; Blood Urea Nitrogen; Fatty Acids, Nonesterified; Female; Idazoxan; Imidazoles; Isoproterenol; Male; Random Allocation; Swine | 1998 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Enzyme Activation; Huntington Disease; Idazoxan; Imidazoles; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Stimulation of locus coeruleus neurons by non-I1/I2-type imidazoline receptors: an in vivo and in vitro electrophysiological study.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Electrophysiology; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ligands; Locus Coeruleus; Male; Neurons; Potassium Channels; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Vasodilator Agents | 1998 |
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1999 |
Structure of new imidazoline derivatives and their cardiovascular effect in rats.
Topics: Animals; Benzofurans; Blood Pressure; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Phenoxybenzamine; Rats; Rats, Wistar; Receptors, Drug; Structure-Activity Relationship; Yohimbine | 1999 |
Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells.
Topics: Animals; Antazoline; Apoptosis; Benzofurans; Binding Sites; Cell Division; Cell Survival; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; PC12 Cells; Phentolamine; Rats; Receptors, Drug | 2000 |
Drug treatments to reduce excitotoxicity in vivo: a potential for alpha2-adrenoceptor antagonists?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzofurans; Corpus Striatum; Idazoxan; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley | 2000 |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Catheterization; Clonidine; Drug Interactions; Ethanol; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Antihypertensive Agents; Benzofurans; Binding Sites; Blood Pressure; Disease Models, Animal; Heart Rate; Idazoxan; Imidazoles; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2 | 2003 |
Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.
Topics: Animals; Benzofurans; Binding Sites; Cell Line; Cell Survival; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Nitric Oxide; Time Factors | 2003 |
Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds; Electric Stimulation; Heptanes; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Spinal Cord | 2003 |
Effect of BU98008, an imidazoline1-binding site ligand, on body temperature in mice.
Topics: Animals; Benzofurans; Binding Sites; Body Temperature; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Isoquinolines; Ligands; Male; Mice; Receptors, Drug | 2005 |
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Muscle Relaxants, Central; Norepinephrine; Oxidopamine; Rats; Rats, Wistar; Receptors, Drug; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Spinal Cord; Sympathetic Nervous System; Time Factors | 2005 |
Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Benzofurans; CHO Cells; Cricetinae; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Models, Molecular; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Opioid, mu; Yohimbine | 2006 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |
Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test.
Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Benzofurans; Biguanides; Bupropion; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Guanidines; Idazoxan; Imidazoles; Immobility Response, Tonic; Injections, Intraventricular; Male; Mice; Motor Activity | 2013 |
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Binding Sites; Drug Synergism; Female; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Morphine; Naloxone; Narcotic Antagonists; Pain, Postoperative; Quinazolines; Rats, Sprague-Dawley; Yohimbine | 2014 |
Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs.
Topics: Adult; Animals; Antibodies; Benzofurans; Binding Sites; Brain; Cell Membrane; Cytosol; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Mice; Styrenes; Up-Regulation | 2015 |
Circulatory effect of TCS-80, a new imidazoline compound, in rats.
Topics: Animals; Benzofurans; Blood Pressure; Heart Rate; Hypotension; Idazoxan; Imidazoles; Imidazolidines; Imidazoline Receptors; Imidazolines; Indazoles; Male; Rats; Receptors, Adrenergic, alpha-2 | 2016 |
Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice.
Topics: Animals; Benzofurans; Cerebral Cortex; Cyclin-Dependent Kinase 5; Glutamic Acid; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Kainic Acid; Ligands; Male; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Styrenes; Time Factors | 2016 |
Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Pressure Determination; Clonidine; Consciousness; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 2019 |
Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex-a relevant mechanism in the pathophysiology and treatment of depression?
Topics: Action Potentials; Agmatine; Animals; Benzofurans; Depression; Female; Habenula; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Middle Aged; Neurons; Rats, Wistar; Ureohydrolases | 2018 |
Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors.
Topics: Agmatine; Animals; Arginine; Benzofurans; Biguanides; Central Nervous System Sensitization; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Infusions, Intraventricular; Male; Mice; Microinjections; Motor Activity | 2019 |
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field.
Topics: Animals; Area Under Curve; Benzofurans; CHO Cells; Cricetulus; Humans; Idazoxan; Imidazoles; Imidazolines; Ligands; Molecular Docking Simulation; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Reproducibility of Results | 2020 |
Effects of imidazoline agents in a rat conditioned place preference model of addiction.
Topics: Agmatine; Analgesics, Opioid; Animals; Benzofurans; Conditioning, Psychological; Drug Interactions; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Wistar; Time Factors; Tramadol | 2022 |