efaroxan has been researched along with benzofurans in 144 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.69) | 18.7374 |
| 1990's | 54 (37.50) | 18.2507 |
| 2000's | 62 (43.06) | 29.6817 |
| 2010's | 25 (17.36) | 24.3611 |
| 2020's | 2 (1.39) | 2.80 |
| Authors | Studies |
|---|---|
| Berridge, TL; Doxey, JC; Roach, AG; Smith, CF | 1 |
| Berridge, TL; Doxey, JC; Roach, AG | 1 |
| Chan, SL; Morgan, NG; Stillings, MR | 1 |
| Chan, SL; Dunne, MJ; Morgan, NG; Stillings, MR | 1 |
| Chan, SL; Morgan, NG | 2 |
| Hyde, NA; Nichols, JD; Sugden, K | 1 |
| Dreshaj, I; Ernsberger, P; Haxhiu, MA; Schäfer, SG | 1 |
| Colpaert, F; Marien, M; Tellez, S | 2 |
| Carlisle, MA; Glavin, GB; Smyth, DD | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Tsoli, E | 1 |
| Campbell, WR; Potter, DE | 2 |
| Berdeu, D; Bertrand, G; Gross, R; Loubatières-Mariani, MM; Puech, R | 1 |
| Haque, M; Kulkarni, RN; MacDermot, J; Olmos, G | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Smith, SA; Stillings, MR | 1 |
| Berdeu, D; Bertrand, G; Gross, R; Loubatières-Mariani, MM; Ribes, G | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Scarpello, KE | 1 |
| Brown, CA; Chan, SL; Morgan, NG | 1 |
| Brown, CA; Morgan, NG | 1 |
| Chan, SL; Morgan, NG; Tsoli, E | 1 |
| Ernsberger, P; Kester, M; Separovic, D | 1 |
| Starke, K; Trendelenburg, AU; Wahl, CA | 1 |
| Chan, CK; Head, GA | 1 |
| Berdeu, D; Bertrand, G; Loubatières-Mariani, MM; Puech, R | 1 |
| Chu, TC; Gluchowski, C; Hughes, BW; Potter, DE; Wong, W | 1 |
| Dunne, MJ; Hashmi, MN; Kane, C; Shepherd, RM; Squires, PE | 1 |
| Alper, SL; Armsby, CC; Brugnara, C; Coupry, I; Parini, A | 1 |
| Pol, O; Puig, MM; Warner, W | 1 |
| Chan, SL; Clews, J; Morgan, NG; Pallett, AL; Ramsden, CA | 1 |
| Kleven, MS; Koek, W | 1 |
| Brown, CA; Chan, SL; Morgan, NG; Mourtada, M; Piercy, V; Smith, SA | 1 |
| Ally, A | 1 |
| Chu, TC; Ogidigben, MJ; Potter, DE; Socci, RR | 1 |
| Chan, SL; Morgan, NG; Pallett, AL | 1 |
| Baez, M; Kursar, JD; Lucaites, VL; Nelson, DL; Sasso, DA; Wainscott, DB | 1 |
| Brefel-Courbon, C; Ladure, P; Lees, A; Montastruc, JL; Peyro-Saint-Paul, H; Rascol, O; Senard, JM; Sieradzan, K; Thalamas, C | 1 |
| Cleale, RM; Hadcock, JR; Ingling, JM; Pausch, MH; Search, DJ | 1 |
| Morgan, NG; Mourtada, M; Smith, SA | 1 |
| Chan, SL; Chapman, JC; Clews, J; Dunne, MJ; Kane, C; Morgan, NG; Pallett, AL; Ramsden, CA | 1 |
| Dreshaj, IA; Ernsberger, P; Erokwu, BO; Haxhiu, MA; McFadden, CB | 2 |
| Ernsberger, P | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, J | 1 |
| Martín-Ruiz, R; Pineda, J; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Chopin, P; Colpaert, FC; Marien, M | 1 |
| Bock, C; Niederhoffer, N; Szabo, B | 1 |
| Fairbanks, CA; Wilcox, GL | 1 |
| Debowski, T; Krzystanek, E; Krzystanek, M; Saczewski, F; Trzeciak, H | 1 |
| Esteban, S; García-Sevilla, JA; Sastre-Coll, A | 1 |
| Brunel, P; Imbert, T; Mayer, P | 1 |
| Couture, K; Gouverneur, V; Mioskowski, C | 1 |
| Ammälä, C; Chapman, JC; Cosgrove, KE; Dunne, MJ; Flatt, PR; Giesberts, AN; Hashmi, MN; McClenaghan, NH; Shepherd, RM; White, SJ | 1 |
| He, RR; Xu, YF | 1 |
| Elliott, J; Morgan, NG; Mourtada, M; Smith, SA | 1 |
| Lutz, EA; Shannon, HE | 1 |
| Badoer, E; Musgrave, IF | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH; McCluskey, JT | 1 |
| Dreshaj, IA; Ernsberger, P; Haxhiu, MA; Tolentino-Silva, FP; Waldbaum, S | 1 |
| Gutkowska, J; Mukaddam-Daher, S | 1 |
| Chopin, P; Colpaert, F; Marien, M; Martel, JC | 1 |
| Chu, TC; Ogidigben, MJ; Potter, DE | 1 |
| Ball, AJ; Flatt, PR; McClenaghan, NH | 1 |
| Chan, SL; Morgan, NG; Mourtada, M | 1 |
| Appelskog, IB; Berggren, PO; Efendic, S; Kapelioukh, IL; Köhler, M; Yang, SN; Zaitsev, SV | 1 |
| Abdel-Rahman, AA; El-Mas, MM; Zhang, J | 1 |
| Gandía, L; García, AG; Hernández-Guijo, JM; Jurkiewicz, A; Olivares, R; Ruiz-Nuño, A; Santos, WC | 1 |
| Abdel-Rahman, AA; El-Mas, MM | 1 |
| Khokhlova, ON; Medvedev, OS; Murashev, AN | 1 |
| Ogidigben, MJ; Potter, DE | 2 |
| Abdel-Zaher, AO; Ahmed, IT; El-Koussi, AD | 1 |
| Chan, SL; Deaville, P; Gao, H; Monks, LK; Morgan, NG | 1 |
| Mayer, G; Taberner, PV | 1 |
| Antoine, MH; Aynsley-Green, A; Barnes, PD; Clayton, P; Cosgrove, KE; De Lonlay, P; de Tullio, P; Dunne, MJ; Hussain, K; Lebrun, P; Lee, AT; Lindley, KJ; McCloy, R; Nihoul-Fékété, C; Pirotte, B; Rahier, J; Robert, JJ; Saudubray, JM | 1 |
| Godwin, SJ; Head, GA; Parkin, ML | 1 |
| Dominiak, P; Häuser, W; Jungbluth, B; Raasch, W; Schäfer, U | 2 |
| Gao, H; Morgan, NG; Mourtada, M | 1 |
| Egan, JA; Filer, CN | 1 |
| Cao, C; Kang, CW; Kim, SH; Kim, SZ | 1 |
| Cooper, EJ; Hills, CE; Hudson, AL; Morgan, NG; Parker, CA; Squires, PE | 1 |
| Ernsberger, P; Koletsky, RJ; Velliquette, RA | 1 |
| Burgdorf, C; Engelhardt, A; Kurz, T; Raasch, W; Richardt, G; Schäfer, U | 1 |
| Abelson, KS; Höglund, AU | 1 |
| Merwid-Lad, A; Misiuk-Hojło, M; Pieśniewska, M; Szaliński, M; Trocha, M | 1 |
| Korobov, NV; Kozaeva, LP; Medvedev, OS | 1 |
| D'Aquino, R; Graziano, A; Nicoletti, F; Papaccio, G; Travali, S; Valiante, S | 1 |
| Bleck, C; Rustenbeck, I; Wienbergen, A | 2 |
| Bleck, C; Jörns, A; Rustenbeck, I; Wienbergen, A | 1 |
| El-Ayoubi, R; Gutkowska, J; Menaouar, A; Mukaddam-Daher, S | 1 |
| Asrican, B; Lewey, J; Lisman, JE; Otmakhova, NA | 1 |
| Abdel-Rahman, AA; Zhang, J | 1 |
| Abdel-Rahman, AA; Li, G; Wang, X | 2 |
| Cambridge, N; Robinson, ES | 1 |
| Honda, M; Kino, Y; Ono, H; Tanabe, M | 1 |
| Hayashi, Y; Itoh, I; Iwasaki, M; Kagawa, K; Kamibayashi, T; Mashimo, T; Takada, K; Yamatodani, A | 1 |
| Berggren, PO; Efendic, S; Guerin, C; Mandrup-Poulsen, T; Nicotera, P; Sharoyko, V; Størling, J; Zaitsev, SV; Zaitseva, II | 1 |
| Khansefid, N; Ladgevardi, MA; Sabetkasaie, M | 1 |
| Chan, SL; Jackson, DA; Morgan, NG; Taylor, JP | 1 |
| Cardinaletti, C; Carrieri, A; Gentili, F; Ghelfi, F; Mattioli, L; Perfumi, M; Pigini, M; Vesprini, C | 1 |
| Delepee, R; Lorin, M; Maurizot, JC; Morin, P; Ribet, JP | 1 |
| Delépée, R; Lorin, M; Morin, P; Ribet, JP | 2 |
| Gabilan, NH; Rodrigues, AL; Rosa, AO; Zeidan, MP; Zomkowski, AD | 1 |
| Gao, L; Wang, LG; Wang, W; Wang, WZ; Yuan, WJ | 1 |
| Berggren, PO; Mandrup-Poulsen, T; Størling, J; Zaitsev, SV; Zaitseva, II | 1 |
| Guertin, PA; Lapointe, NP; Rouleau, P; Ung, RV | 1 |
| Jesse, CR; Nogueira, CW; Savegnago, L | 1 |
| Fagerholm, V; Haaparanta, M; Scheinin, M | 1 |
| Hashimoto, M; Ono, H; Tanabe, M | 1 |
| Fujii, T; Hayashi, K; Kobuchi, S; Matsumura, Y; Sugiura, T; Takaoka, M; Tsutsui, H | 1 |
| Sun, N; Xiong, Q; Yang, J; Yang, R | 1 |
| Ni, X; Su, DF; Wang, JL; Wang, L; Wang, WZ; Wu, ZT; Yan, JJ; Yuan, WJ | 1 |
| Henquin, JC; Nenquin, M; Szollosi, A | 1 |
| Chen, Y; Li, F; Li, J; Liu, Y; Lu, X; Su, R; Wu, N | 1 |
| Cheng, JT; Chiu, NH; Chung, HH; Hsu, CT; Lee, WJ; Yang, TT | 1 |
| Chen, MF; Cheng, JT; Chou, MT; Chung, HH; Yang, TT | 1 |
| Adorjan, I; Bauer, L; Belz, M; Brunmair, B; de Cillia, VA; Fenzl, A; Frobel, K; Fürnsinn, C; Gruber, D; Lehner, Z; Luger, A; Rustenbeck, I; Stadlbauer, K | 1 |
| Ali, I; Andurkar, SV; Bhalla, S; Gulati, A; Lee, H | 1 |
| Amit, T; Angel, I; Bar-Am, O; Barac, YD; Binah, O; Frolov, L; Liani, E; Ovcharenko, E; Youdim, MB | 1 |
| Chen, MF; Cheng, JT; Chiu, NH; Chou, MT; Chung, HH; Mar, GY | 1 |
| Agbaba, D; Gemovic, B; Nikolic, K; Srdic-Rajic, T; Veljkovic, N | 1 |
| Cahill, CM; Grenier, P; Jhamandas, K; Milne, B; Sutak, M | 1 |
| Aglawe, MM; Chopde, CT; Kotagale, NR; Taksande, BG; Tripathi, SJ; Umekar, MJ | 1 |
| Hayashi, K; Matsumura, Y; Ohkita, M; Sugiura, T; Takaoka, M; Tsutsui, H; Yukimura, T | 1 |
| Alekseev, AE; Evdokimovskii, EV; Kokoz, YM; Maltsev, AV; Pimenov, OY; Reyes, S | 1 |
| Caselli, G; Ferrari, F; Lanza, M; Menghetti, I; Tremolada, D | 1 |
| Cole, SW; David, JM; Lamkin, DM; Ma, JC; Sloan, EK; Sung, HY; Yang, GS | 1 |
| García-Sevilla, JA; Keller, B | 2 |
| Berggren, PO; Zaitsev, SV; Zaitseva, II | 1 |
| Hu, QK; Tan, X; Wang, WZ; Wang, YK; Wu, ZT; Yang, YH; Yu, Q; Yuan, WJ; Zhang, RW | 1 |
| Boblewski, K; Kornicka, A; Lehmann, A; Marchwińska, A; Rybczyńska, A; Sączewski, F; Sączewski, J | 1 |
| Cahill, CM; Grenier, P; Olmstead, MC; Wiercigroch, D | 1 |
| Nakamoto, M; Ohya, Y; Sakima, A; Takishita, S; Yamazato, M; Yamazato, Y | 1 |
| Kuzmenko, NV; Pliss, MG; Tsyrlin, VA | 1 |
| Bernard, R; Bernstein, HG; Laube, G; Veh, RW; Weiss, T | 1 |
| Aglawe, MM; Chopde, CT; Gujar, S; Khade, SD; Kotagale, NR; Taksande, BG | 1 |
| Djikic, T; Laurila, J; Nikolic, K; Radi, M; Veljkovic, N; Vucicevic, J; Xhaard, H | 1 |
| Manole, OM; Moraru, C; Nechita, P; Rusu-Zota, G; Şorodoc, V | 1 |
2 review(s) available for efaroxan and benzofurans
| Article | Year |
|---|---|
Characterization of the imidazoline binding site involved in regulation of insulin secretion.
Topics: Agmatine; Animals; Benzofurans; Down-Regulation; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; Receptors, Drug | 1995 |
Desensitization of insulin secretion by depolarizing insulin secretagogues.
Topics: Animals; Benzofurans; Calcium; Humans; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Potassium Channels | 2004 |
1 trial(s) available for efaroxan and benzofurans
| Article | Year |
|---|---|
Efaroxan, an alpha-2 antagonist, in the treatment of progressive supranuclear palsy.
Topics: Adrenergic alpha-Antagonists; Adult; Aged; Benzofurans; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Humans; Imidazoles; Male; Middle Aged; Neurologic Examination; Prospective Studies; Supranuclear Palsy, Progressive; Treatment Outcome | 1998 |
141 other study(ies) available for efaroxan and benzofurans
| Article | Year |
|---|---|
Selectivity profile of the alpha 2-adrenoceptor antagonist efaroxan in relation to plasma glucose and insulin levels in the rat.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Clonidine; Decerebrate State; Dioxanes; Dose-Response Relationship, Drug; Epinephrine; Idazoxan; Imidazoles; Insulin; Male; Muscles; Prazosin; Quinoxalines; Rats; Rats, Inbred Strains; Vas Deferens | 1992 |
Comparison of the effects of efaroxan and glibenclamide on plasma glucose and insulin levels in rats.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Glucose; Glyburide; Imidazoles; Insulin; Male; Rats; Rats, Inbred Strains | 1992 |
Mechanisms involved in stimulation of insulin secretion by the hypoglycaemic alpha-adrenergic antagonist, DG-5128.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Dioxanes; Dose-Response Relationship, Drug; Hypoglycemic Agents; Idazoxan; Imidazoles; In Vitro Techniques; Islets of Langerhans; Kinetics; Male; Phentolamine; Rats; Rats, Inbred Strains | 1991 |
The alpha 2-adrenoceptor antagonist efaroxan modulates K+ATP channels in insulin-secreting cells.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Drug Interactions; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Potassium Channels; Rats; Rats, Inbred Strains | 1991 |
Stimulation of insulin secretion by efaroxan may involve interaction with potassium channels.
Topics: Animals; Benzofurans; Diazoxide; Glucose; Hypoglycemic Agents; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Potassium Channels; Rats; Rats, Inbred Strains | 1990 |
Determination of underivatised efaroxan and idazoxan in blood plasma by capillary gas chromatography with mass-selective detection.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Dioxanes; Dioxins; Gas Chromatography-Mass Spectrometry; Humans; Idazoxan; Imidazoles | 1989 |
Selective antihypertensive action of moxonidine is mediated mainly by I1-imidazoline receptors in the rostral ventrolateral medulla.
Topics: Adrenergic alpha-Antagonists; Affinity Labels; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Binding, Competitive; Blood Gas Analysis; Blood Pressure; Blood Pressure Determination; Cattle; Clonidine; Disease Models, Animal; Heart Rate; Hypertension; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Medulla Oblongata; Microinjections; Radioligand Assay; Rats; Rats, Inbred SHR; Receptors, Drug | 1994 |
The alpha 2-adrenoceptor antagonist, (+)-efaroxan, enhances acetylcholine release in the rat cortex in vivo.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cerebral Cortex; Dose-Response Relationship, Drug; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley; Stereoisomerism | 1995 |
Efaroxan acts peripherally to block the antisecretory and gastroprotective effects of moxonidine in rats.
Topics: Animals; Benzofurans; Dose-Response Relationship, Drug; Gastric Acid; Gastric Mucosa; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug | 1995 |
Centrally mediated ocular hypotension: potential role of imidazoline receptors.
Topics: Administration, Topical; Animals; Benzofurans; Cornea; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Intraocular Pressure; Male; Medulla Oblongata; Ocular Hypertension; Rabbits; Receptors, Drug; Sympathectomy, Chemical; Yohimbine | 1995 |
Evidence for two different imidazoline sites on pancreatic B cells and vascular bed in rat.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Antazoline; Benzofurans; Binding, Competitive; Cimetidine; Dioxanes; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptors, Drug; Reference Standards; Tolbutamide; Vascular Resistance | 1995 |
Imidazolines stimulate release of insulin from RIN-5AH cells independently from imidazoline I1 and I2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Affinity Labels; Animals; Benzofurans; Binding, Competitive; Clonidine; Clorgyline; Diazoxide; Dioxanes; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulinoma; Ligands; Pancreatic Neoplasms; Potassium Channels; Rats; Receptors, Drug; Regression Analysis; Software; Tumor Cells, Cultured | 1994 |
Antagonism of the stimulatory effects of efaroxan and glibenclamide in rat pancreatic islets by the imidazoline, RX801080.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Binding, Competitive; Cell Membrane; Drug Interactions; Glyburide; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; Kinetics; Male; Rats; Rats, Wistar; Receptors, Drug; Stimulation, Chemical | 1993 |
Effects of imidazolines and derivatives on insulin secretion and vascular resistance in perfused rat pancreas.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antazoline; Benzofurans; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Male; Pancreas; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-1; Receptors, Adrenergic, alpha-2; Regional Blood Flow; Vascular Resistance; Vasoconstriction | 1994 |
The imidazoline site involved in control of insulin secretion: characteristics that distinguish it from I1- and I2-sites.
Topics: Animals; Benzofurans; Binding Sites; Dioxanes; Down-Regulation; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Male; Rats; Rats, Wistar; Receptors, Drug | 1994 |
Stimulation of insulin secretion by the imidazoline alpha 2-adrenoceptor antagonist efaroxan is mediated by a novel, stereoselective, binding site.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Culture Techniques; Dose-Response Relationship, Drug; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Stereoisomerism | 1993 |
Potential role of imidazoline (I1) receptors in modulating aqueous humor dynamics.
Topics: Administration, Topical; Animals; Aqueous Humor; Benzofurans; Brain; Catheters, Indwelling; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Intraocular Pressure; Male; Ocular Hypotension; Oxymetazoline; Pupil; Rabbits; Receptors, Drug | 1994 |
Control of insulin secretion by imidazolines in rat pancreatic islets.
Topics: Animals; Benzofurans; Diazoxide; Dioxanes; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Rats | 1993 |
The imidazoline I1 receptor agonist, moxonidine, inhibits insulin secretion from isolated rat islets of Langerhans.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cimetidine; Depression, Chemical; Female; Glucose; Histamine H2 Antagonists; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Receptors, Drug | 1995 |
Coupling of I1-imidazoline receptors to diacylglyceride accumulation in PC12 rat pheochromocytoma cells.
Topics: Animals; Benzofurans; Diglycerides; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Nerve Growth Factors; PC12 Cells; Phospholipase D; Rats; Receptors, Drug; Type C Phospholipases | 1996 |
Antagonists that differentiate between alpha 2A-and alpha 2D-adrenoceptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Autoreceptors; Benzofurans; Brimonidine Tartrate; Cerebral Cortex; Dioxanes; Electric Stimulation; Female; Guinea Pigs; Idazoxan; Imidazoles; Isotope Labeling; Male; Norepinephrine; Oxathiins; Quinolizines; Quinoxalines; Rabbits; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tritium | 1996 |
Relative importance of central imidazoline receptors for the antihypertensive effects of moxonidine and rilmenidine.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiac Catheterization; Clonidine; Dose-Response Relationship, Drug; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine; Time Factors | 1996 |
Agmatine is not a good candidate as endogenous ligand for imidazoline sites of pancreatic B cells and vascular bed.
Topics: Agmatine; Animals; Benzofurans; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; Ligands; Male; Protein Binding; Rats; Rats, Wistar; Receptors, Drug | 1996 |
Rilmenidine-induced ocular hypotension: role of imidazoline1 and alpha 2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Calcium; Ciliary Body; Cyclic AMP; Female; Imidazoles; Imidazoline Receptors; Intraocular Pressure; Iris; Male; Norepinephrine; Ocular Hypotension; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathectomy; Sympathetic Nervous System; Yohimbine | 1996 |
Elevation of cytosolic calcium by imidazolines in mouse islets of Langerhans: implications for stimulus-response coupling of insulin release.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Calcium; Cytosol; Down-Regulation; Glucose; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Islets of Langerhans; Mice; Phentolamine; Receptors, Drug; Signal Transduction | 1996 |
Clotrimazole and efaroxan inhibit red cell Gardos channel independently of imidazoline I1 and I2 binding sites.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Binding Sites; Calcium; Clotrimazole; Dose-Response Relationship, Drug; Erythrocytes; Humans; Imidazoles; Potassium Channels | 1996 |
Interaction of morphine and clonidine on gastrointestinal transit in mice.
Topics: Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Benzofurans; Clonidine; Constipation; Dose-Response Relationship, Drug; Drug Interactions; Gastrointestinal Transit; Imidazoles; Male; Mice; Morphine; Naloxone; Narcotic Antagonists; Narcotics; Sympatholytics | 1996 |
Evidence that the ability of imidazoline compounds to stimulate insulin secretion is not due to interaction with sigma receptors.
Topics: Adenosine Triphosphate; Animals; Benzofurans; Dizocilpine Maleate; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Ligands; Phencyclidine; Potassium Channels; Rats; Rats, Wistar; Receptors, Drug; Receptors, sigma | 1997 |
Discriminative stimulus properties of cocaine: enhancement by beta-adrenergic receptor antagonists.
Topics: Adrenergic beta-Antagonists; Animals; Benzofurans; Betaxolol; Brimonidine Tartrate; Cocaine; Discrimination Learning; Discrimination, Psychological; Drug Synergism; Imidazoles; Male; Nadolol; Narcotics; Propanolamines; Propranolol; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Thiophenes | 1997 |
Interactions between imidazoline compounds and sulphonylureas in the regulation of insulin secretion.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Drug Interactions; Glyburide; Hypoglycemic Agents; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Rats; Rats, Wistar; Stereoisomerism | 1997 |
Cardiovascular effects of central administration of clonidine in conscious cats.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Behavior, Animal; Benzofurans; Blood Pressure; Cardiovascular System; Cats; Cimetidine; Clonidine; Coloring Agents; Consciousness; Dose-Response Relationship, Drug; Evans Blue; Female; Heart Rate; Histamine H2 Antagonists; Imidazoles; Injections, Intraventricular; Yohimbine | 1997 |
Potential mechanisms of moxonidine-induced ocular hypotension: role of norepinephrine.
Topics: Administration, Topical; Animals; Antihypertensive Agents; Aqueous Humor; Benzofurans; Dopamine; Female; Imidazoles; Intraocular Pressure; Male; Norepinephrine; Ocular Hypotension; Rabbits; Superior Cervical Ganglion | 1997 |
Clotrimazole and efaroxan stimulate insulin secretion by different mechanisms in rat pancreatic islets.
Topics: Animals; Benzofurans; Clotrimazole; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar | 1997 |
[3H]Rauwolscine: an antagonist radioligand for the cloned human 5-hydroxytryptamine2b (5-HT2B) receptor.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Binding, Competitive; Cell Line; Cloning, Molecular; Humans; Imidazoles; Radioligand Assay; Receptor, Serotonin, 5-HT2B; Receptors, Serotonin; Serotonin Antagonists; Transfection; Tritium; Yohimbine | 1998 |
Effects of alpha2-adrenoceptor antagonists on metabolic processes of swine: I. Effects on nonesterified fatty acid and plasma urea nitrogen concentrations in jugularly catheterized pigs.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Agonists; Animals; Area Under Curve; Benzofurans; Blood Urea Nitrogen; Fatty Acids, Nonesterified; Female; Idazoxan; Imidazoles; Isoproterenol; Male; Random Allocation; Swine | 1998 |
Effector systems involved in the insulin secretory responses to efaroxan and RX871024 in rat islets of Langerhans.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Calcium; Calcium Channel Blockers; Cyclic AMP; Down-Regulation; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indoles; Insulin; Insulin Secretion; Islets of Langerhans; Male; Protein Kinase C; Protein Kinase Inhibitors; Rats; Rats, Wistar | 1998 |
Sigma receptor ligands and imidazoline secretagogues mediate their insulin secretory effects by activating distinct receptor systems in isolated islets.
Topics: Adrenergic alpha-Antagonists; Animals; Azides; Benzofurans; Dopamine Agonists; Dose-Response Relationship, Drug; Guanidines; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Ligands; Male; Piperidines; Rats; Rats, Wistar; Receptors, Drug; Receptors, sigma | 1998 |
Characterisation of new efaroxan derivatives for use in purification of imidazoline-binding sites.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cells, Cultured; Female; Imidazoles; Imidazoline Receptors; Islets of Langerhans; Male; Patch-Clamp Techniques; Potassium Channel Blockers; Rats; Rats, Wistar; Receptors, Drug; Structure-Activity Relationship | 1998 |
I1-imidazoline receptors and cholinergic outflow to the airways.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cholinergic Fibers; Dogs; Electric Stimulation; Heart Rate; Imidazoles; Imidazoline Receptors; Mechanoreceptors; Muscle Contraction; Muscle, Smooth; Nerve Endings; Neurons, Afferent; Receptors, Drug; Trachea; Vagus Nerve; Vasodilator Agents | 1998 |
Arachidonic acid release from PC12 pheochromocytoma cells is regulated by I1-imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arachidonic Acid; Aristolochic Acids; Benzofurans; Enzyme Inhibitors; Guanabenz; Imidazoles; Imidazoline Receptors; PC12 Cells; Phenanthrenes; Phospholipases A; Phospholipases A2; Rats; Receptors, Drug | 1998 |
Neuroprotective effects of the alpha2-adrenoceptor antagonists, (+)-efaroxan and (+/-)-idazoxan, against quinolinic acid-induced lesions of the rat striatum.
Topics: Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Choline O-Acetyltransferase; Corpus Striatum; Disease Models, Animal; Dopamine Agonists; Enzyme Activation; Huntington Disease; Idazoxan; Imidazoles; Male; Nerve Degeneration; Neuroprotective Agents; Neurotoxins; Quinolinic Acid; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2 | 1998 |
Stimulation of locus coeruleus neurons by non-I1/I2-type imidazoline receptors: an in vivo and in vitro electrophysiological study.
Topics: Adenosine Triphosphate; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Diazoxide; Electrophysiology; Idazoxan; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Ligands; Locus Coeruleus; Male; Neurons; Potassium Channels; Rats; Receptors, Adrenergic, alpha-2; Receptors, Drug; Vasodilator Agents | 1998 |
Effects of alpha-2 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6-hydroxydopamine lesions of the nigrostriatal pathway.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Apomorphine; Behavior, Animal; Benzofurans; Brimonidine Tartrate; Clonidine; Dopamine Agonists; Idazoxan; Imidazoles; Ligands; Male; Methylphenidate; Oxidopamine; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Stereoisomerism; Stereotyped Behavior; Substantia Nigra | 1999 |
Analysis of the receptor involved in the central hypotensive effect of rilmenidine and moxonidine.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Female; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Methyldopa; Norepinephrine; Oxazoles; Rabbits; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Yohimbine | 1999 |
Alpha2-adrenoceptor modulation of cortical acetylcholine release in vivo.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Benzylamines; Brimonidine Tartrate; Cerebellum; Cerebral Cortex; Epinephrine; Globus Pallidus; Imidazoles; In Vitro Techniques; Kinetics; Parietal Lobe; Prefrontal Cortex; Quinoxalines; Rats; Receptors, Adrenergic, alpha-2; Substantia Innominata; Sympathomimetics | 1999 |
Moxonidine, a selective alpha2-adrenergic and imidazoline receptor agonist, produces spinal antinociception in mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Autoreceptors; Benzazepines; Benzofurans; Dose-Response Relationship, Drug; Female; Imidazoles; Imidazoline Receptors; Injections, Spinal; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Nerve Endings; Norepinephrine; Pain Measurement; Receptors, Adrenergic, alpha-2; Receptors, Drug; Spinal Cord | 1999 |
Structure of new imidazoline derivatives and their cardiovascular effect in rats.
Topics: Animals; Benzofurans; Blood Pressure; Female; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Phenoxybenzamine; Rats; Rats, Wistar; Receptors, Drug; Structure-Activity Relationship; Yohimbine | 1999 |
Effects of imidazoline drugs on tyrosine and tryptophan hydroxylase activity in rat brain in vivo.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Brain; Clonidine; Dihydroxyphenylalanine; Imidazoles; Male; Quinolines; Rats; Rats, Sprague-Dawley; Serotonin; Serotonin Antagonists; Tryptophan Hydroxylase; Tyrosine 3-Monooxygenase | 1999 |
Moxonidine acting centrally inhibits airway reflex responses.
Topics: Acetylcholine; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Decerebrate State; Dogs; Efferent Pathways; Electric Stimulation; Heart Rate; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Lung; Muscle, Smooth; Nerve Fibers; Neurons, Afferent; Receptors, Drug; Reflex; Trachea; Vagus Nerve | 1999 |
A new efficient synthesis of efaroxan.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Imidazoles | 1999 |
A new approach to the synthesis of efaroxan.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Epoxy Compounds; Imidazoles | 1999 |
ATP-sensitive potassium channels and efaroxan-induced insulin release in the electrofusion-derived BRIN-BD11 beta-cell line.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cell Fusion; Cell Line; Diazoxide; Glucose; Imidazoles; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Membrane Potentials; Pancreatic Neoplasms; Phentolamine; Pinacidil; Potassium Channels; Tolbutamide; Tumor Cells, Cultured | 1999 |
Effect of moxonidine on carotid sinus baroreflex in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Benzofurans; Blood Pressure; Carotid Sinus; Imidazoles; Male; Rats; Vascular Resistance | 1999 |
Effects of imidazoline binding site ligands on the growth and viability of clonal pancreatic beta-cells.
Topics: Animals; Antazoline; Apoptosis; Benzofurans; Binding Sites; Cell Division; Cell Survival; Idazoxan; Imidazoles; Imidazoline Receptors; Insulin; Insulin Secretion; Islets of Langerhans; PC12 Cells; Phentolamine; Rats; Receptors, Drug | 2000 |
Effects of the I(1) imidazoline/alpha(2)-adrenergic receptor agonist moxonidine in comparison with clonidine in the formalin test in rats.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Formaldehyde; Imidazoles; Imidazoline Receptors; Injections, Subcutaneous; Male; Pain; Pain Measurement; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Drug; Time Factors; Yohimbine | 2000 |
Harmane produces hypotension following microinjection into the RVLM: possible role of I(1)-imidazoline receptors.
Topics: Adrenergic alpha-Agonists; Animals; Benzofurans; Blood Pressure; Clonidine; Harmine; Heart Rate; Hypotension; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Microinjections; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2000 |
Drug-induced desensitization of insulinotropic actions of sulfonylureas.
Topics: Adenosine Triphosphate; Adrenergic alpha-Antagonists; Animals; Benzofurans; Cell Line; Dose-Response Relationship, Drug; Glucose; Guanidines; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Potassium Channels; Potassium Chloride; Rats; Tolbutamide | 2000 |
alpha(2)-adrenergic receptors are not required for central anti-hypertensive action of moxonidine in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Amygdala; Animals; Antihypertensive Agents; Benzofurans; Binding, Competitive; Blood Pressure; Brain Chemistry; Glutamic Acid; Heart Rate; Hypertension; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Medulla Oblongata; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microinjections; Pons; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2000 |
Atrial natriuretic peptide is involved in renal actions of moxonidine.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Natriuretic Factor; Benzofurans; Cyclic GMP; Diuresis; Dose-Response Relationship, Drug; Female; Imidazoles; Imidazoline Receptors; Injections, Intravenous; Kidney; Natriuresis; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Drug; Yohimbine | 2000 |
Drug treatments to reduce excitotoxicity in vivo: a potential for alpha2-adrenoceptor antagonists?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzofurans; Corpus Striatum; Idazoxan; Imidazoles; Male; Microdialysis; Rats; Rats, Sprague-Dawley | 2000 |
Naphazoline-induced suppression of aqueous humor pressure and flow: involvement of central and peripheral alpha(2)/I(1) receptors.
Topics: Administration, Topical; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analysis of Variance; Animals; Aqueous Humor; Benzofurans; Dose-Response Relationship, Drug; Drug Synergism; Female; Imidazoles; Injections, Intraventricular; Intraocular Pressure; Male; Naphazoline; Pertussis Toxin; Pupil; Rabbits; Receptors, Adrenergic, alpha-2; Virulence Factors, Bordetella | 2001 |
Specific desensitization of sulfonylurea- but not imidazoline-induced insulin release after prolonged tolbutamide exposure.
Topics: Animals; Benzofurans; Cell Line; Drug Interactions; Glucose; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Rats; Sulfonylurea Compounds; Time Factors; Tolbutamide | 2001 |
Characterization of a KATP channel-independent pathway involved in potentiation of insulin secretion by efaroxan.
Topics: 1-Methyl-3-isobutylxanthine; Adenosine Triphosphate; Animals; Benzofurans; Bucladesine; Cyclic AMP; Diazoxide; Glucose; Imidazoles; In Vitro Techniques; Insulin; Insulin Secretion; Islets of Langerhans; Male; Permeability; Phosphodiesterase Inhibitors; Potassium Channels; Rats; Rats, Wistar | 2001 |
Imidazoline compounds protect against interleukin 1beta-induced beta-cell apoptosis.
Topics: Animals; Apoptosis; Benzofurans; Calcineurin; Calcineurin Inhibitors; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gallopamil; Imidazoles; Indoles; Interleukin-1; Islets of Langerhans; Membrane Potentials; Mice; Mice, Obese; Models, Biological; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitriles; Patch-Clamp Techniques; Pyrethrins | 2001 |
Imidazoline I(1) receptor-induced activation of phosphatidylcholine-specific phospholipase C elicits mitogen-activated protein kinase phosphorylation in PC12 cells.
Topics: Acetylcholine; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Choline; Diglycerides; Enzyme Activation; Imidazoles; Imidazoline Receptors; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Nerve Growth Factor; Oxazoles; PC12 Cells; Phosphorylation; Phosphorylcholine; Rats; Receptors, Drug; Rilmenidine; Signal Transduction; Type C Phospholipases | 2001 |
Blockade by agmatine of catecholamine release from chromaffin cells is unrelated to imidazoline receptors.
Topics: Acetylcholine; Agmatine; Animals; Benzofurans; Binding Sites; Binding, Competitive; Calcium Channels; Catecholamines; Cattle; Cells, Cultured; Chromaffin Cells; Clonidine; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Imidazoline Receptors; Membrane Potentials; Potassium; Potassium Channels; Receptors, Drug; Receptors, Nicotinic; Sodium Channels | 2001 |
Evidence for the involvement of central I1 imidazoline receptor in ethanol counteraction of clonidine hypotension in spontaneously hypertensive rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Catheterization; Clonidine; Drug Interactions; Ethanol; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug | 2001 |
Role of I(1)-imidazoline receptors and alpha2-adrenoceptors in hemodynamic effects of moxonidine administration into the rostroventrolateral medulla.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Heart Rate; Hemodynamics; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 2001 |
Central imidazoline (I(1)) receptors modulate aqueous hydrodynamics.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Aqueous Humor; Benzofurans; Brain; Dose-Response Relationship, Drug; Female; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Intraocular Pressure; Male; Rabbits; Receptors, Drug; Sympathectomy; Sympathetic Nervous System | 2001 |
The potential antidiabetic activity of some alpha-2 adrenoceptor antagonists.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Aorta, Thoracic; Benzofurans; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Drug Therapy, Combination; Hypoglycemic Agents; Imidazoles; In Vitro Techniques; Insulin; Male; Rabbits; Rats; Rats, Wistar; Vasodilation; Yohimbine | 2001 |
Identification of the monomeric G-protein, Rhes, as an efaroxan-regulated protein in the pancreatic beta-cell.
Topics: Animals; Antibody Specificity; Benzofurans; Cells, Cultured; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; GTP-Binding Proteins; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Rabbits; Rats; Reverse Transcriptase Polymerase Chain Reaction | 2002 |
Effects of the imidazoline ligands efaroxan and KU14R on blood glucose homeostasis in the mouse.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Blood Glucose; Brimonidine Tartrate; Dose-Response Relationship, Drug; Drug Interactions; Electric Stimulation; Homeostasis; Hypoglycemic Agents; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Insulin; Ligands; Male; Mice; Mice, Inbred CBA; Piperazines; Quinoxalines; Receptors, Drug; Time Factors; Vas Deferens | 2002 |
BPDZ 154 activates adenosine 5'-triphosphate-sensitive potassium channels: in vitro studies using rodent insulin-secreting cells and islets isolated from patients with hyperinsulinism.
Topics: Adenosine Triphosphate; Adolescent; Adrenergic alpha-Antagonists; Animals; Benzofurans; Benzothiadiazines; Calcium Radioisotopes; Cell Line; Child, Preschool; Cyclic S-Oxides; Female; Glucose; Humans; Hyperinsulinism; Hypoglycemic Agents; Imidazoles; Infant; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Male; Pancreatic Neoplasms; Potassium Channels; Rats; Rats, Wistar; Rubidium Radioisotopes; Tolbutamide | 2002 |
Importance of imidazoline-preferring receptors in the cardiovascular actions of chronically administered moxonidine, rilmenidine and clonidine in conscious rabbits.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Cardiovascular System; Clonidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fourth Ventricle; Heart Rate; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraventricular; Male; Oxazoles; Rabbits; Receptors, Drug; Rilmenidine | 2003 |
Modification of noradrenaline release in pithed spontaneously hypertensive rats by I1-binding sites in addition to alpha2-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Antihypertensive Agents; Benzofurans; Binding Sites; Blood Pressure; Disease Models, Animal; Heart Rate; Idazoxan; Imidazoles; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2 | 2003 |
Pharmacological evidence of a role for prejunctional imidazoline (I(1)) receptors in ocular function.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Brimonidine Tartrate; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Imidazoles; Imidazoline Receptors; Nictitating Membrane; Ocular Physiological Phenomena; Platelet Aggregation Inhibitors; Quinoxalines; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 2002 |
Effects of the imidazoline binding site ligands, idazoxan and efaroxan, on the viability of insulin-secreting BRIN-BD11 cells.
Topics: Animals; Benzofurans; Binding Sites; Cell Line; Cell Survival; DNA; DNA Fragmentation; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Insulin; Insulin Secretion; Interleukin-1; Islets of Langerhans; Nitric Oxide; Time Factors | 2003 |
Tritium labelling and characterization of the potent imidazoline I1 receptor antagonist [5,7-3H] (+/-)-efaroxan at high specific activity.
Topics: Benzofurans; Imidazoles; Imidazoline Receptors; Isotope Labeling; Magnetic Resonance Spectroscopy; Protons; Radioligand Assay; Receptors, Drug; Tritium | 2003 |
Augmentation of moxonidine-induced increase in ANP release by atrial hypertrophy.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Atrial Function; Atrial Natriuretic Factor; Benzofurans; Blood Pressure; Cardiomegaly; Clonidine; Heart Atria; Hemodynamics; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug; Yohimbine | 2004 |
Comparative effects of efaroxan and beta-carbolines on the secretory activity of rodent and human beta cells.
Topics: Adrenergic alpha-Antagonists; Animals; Benzofurans; Binding Sites; Calcium; Carbolines; Cells, Cultured; Diazoxide; Glucose; Humans; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Ligands; Male; Rats; Rats, Wistar | 2003 |
The role of I(1)-imidazoline receptors and alpha(2)-adrenergic receptors in the modulation of glucose and lipid metabolism in the SHROB model of metabolic syndrome X.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Disease Models, Animal; Female; Glucagon; Glucose; Glucose Tolerance Test; Humans; Imidazoles; Imidazoline Receptors; Lipid Metabolism; Male; Metabolic Syndrome; Obesity; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Yohimbine | 2003 |
Moxonidine displays a presynaptic alpha-2-adrenoceptor-dependent synergistic sympathoinhibitory action at imidazoline-1 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Bridged Bicyclo Compounds; Brimonidine Tartrate; Drug Synergism; Heart; Heptanes; Imidazoles; Imidazoline Receptors; Norepinephrine; Oxazoles; Quinoxalines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; Sympathetic Nervous System; Sympatholytics; Yohimbine | 2003 |
Norepinephrine release is reduced by I(1)-receptors in addition to alpha(2)-adrenoceptors.
Topics: Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Blood Pressure; Bridged Bicyclo Compounds; Electric Stimulation; Heptanes; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Norepinephrine; Phenoxybenzamine; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Spinal Cord | 2003 |
The effects of the alpha2-adrenergic receptor agonists clonidine and rilmenidine, and antagonists yohimbine and efaroxan, on the spinal cholinergic receptor system in the rat.
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzofurans; Binding, Competitive; Clonidine; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Injections, Spinal; Ligands; Male; Microdialysis; Oxazoles; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Cholinergic; Rilmenidine; Spinal Cord; Time Factors; Yohimbine | 2004 |
[Effect of rilmenidine on intraocular pressure in rabbits, interaction with efaroxan and rauwolscine].
Topics: Administration, Topical; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Drug Interactions; Glaucoma; Imidazoles; Intraocular Pressure; Male; Oxazoles; Rabbits; Rilmenidine; Time Factors; Yohimbine | 2004 |
Effect of moxonidine on contractile activity of isolated large intestine in mice: role of alpha2-adrenoceptors and Ii-imidazoline receptors.
Topics: Animals; Benzofurans; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Intestine, Large; Mice; Muscle Contraction; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 2004 |
Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection.
Topics: Aconitate Hydratase; Adrenergic alpha-Antagonists; Amidines; Animals; bcl-2-Associated X Protein; Benzofurans; Benzylamines; Caspases; Cell Death; Cells, Cultured; Cytochromes c; Drug Interactions; Enzyme Inhibitors; Gene Expression Profiling; Imidazoles; Insulin; Interleukin-1; Islets of Langerhans; Mitochondria; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitrites; Proto-Oncogene Proteins c-bcl-2; Rats; Rats, Wistar; RNA, Messenger; Superoxide Dismutase | 2005 |
Glucose dependence of imidazoline-induced insulin secretion: different characteristics of two ATP-Sensitive K+ channel-blocking compounds.
Topics: Animals; Benzofurans; Cells, Cultured; Glucose; Imidazoles; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Mice; Mice, Inbred Strains; Potassium Channels | 2004 |
Urinary responses to acute moxonidine are inhibited by natriuretic peptide receptor antagonist.
Topics: Animals; Antihypertensive Agents; Benzofurans; Clonidine; Cyclic GMP; Diuresis; Dose-Response Relationship, Drug; Female; Imidazoles; Imidazoline Receptors; Natriuresis; Natriuretic Peptides; Peptides, Cyclic; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Receptors, Drug; Yohimbine | 2005 |
Inhibition of perforant path input to the CA1 region by serotonin and noradrenaline.
Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Animals, Newborn; Benzofurans; Dopamine; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; Imidazoles; In Vitro Techniques; Neural Inhibition; Neurons; Norepinephrine; Patch-Clamp Techniques; Perforant Pathway; Propranolol; Rats; Rats, Long-Evans; Serotonin; Serotonin Agents; Yohimbine | 2005 |
Mitogen-activated protein kinase phosphorylation in the rostral ventrolateral medulla plays a key role in imidazoline (i1)-receptor-mediated hypotension.
Topics: Animals; Benzofurans; Blood Pressure; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Oxazoles; Phosphorylation; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rilmenidine; Signal Transduction | 2005 |
Site-dependent inhibition of neuronal c-jun in the brainstem elicited by imidazoline I1 receptor activation: role in rilmenidine-evoked hypotension.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzazepines; Benzofurans; Blood Pressure; Brain Stem; Cerebrospinal Fluid; Clonidine; Consciousness; Gene Expression; Heart Rate; Hydralazine; Hypotension; Imidazoles; Imidazoline Receptors; Immunohistochemistry; Male; Medulla Oblongata; Neurons; Nordefrin; Oxazoles; Proto-Oncogene Proteins c-jun; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Receptors, Drug; Rilmenidine; RNA, Messenger; Time Factors; Vasoconstrictor Agents; Vasodilator Agents | 2005 |
Neuronal norepinephrine responses of the rostral ventrolateral medulla and nucleus tractus solitarius neurons distinguish the I1- from the alpha2-receptor-mediated hypotension in conscious SHRs.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Area Postrema; Benzazepines; Benzofurans; Blood Pressure; Clonidine; Consciousness; Heart Rate; Hypotension; Imidazoles; Interleukin-1; Male; Motor Activity; Neurons; Nordefrin; Norepinephrine; Oxazoles; Rats; Rats, Inbred SHR; Receptors, Adrenergic, alpha-2; Rilmenidine; Solitary Nucleus | 2005 |
Effect of BU98008, an imidazoline1-binding site ligand, on body temperature in mice.
Topics: Animals; Benzofurans; Binding Sites; Body Temperature; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Isoquinolines; Ligands; Male; Mice; Receptors, Drug | 2005 |
Involvement of supraspinal imidazoline receptors and descending monoaminergic pathways in tizanidine-induced inhibition of rat spinal reflexes.
Topics: 5,6-Dihydroxytryptamine; Adrenergic Agents; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Dose-Response Relationship, Drug; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Muscle Relaxants, Central; Norepinephrine; Oxidopamine; Rats; Rats, Wistar; Receptors, Drug; Reflex, Monosynaptic; Serotonin; Serotonin Agents; Spinal Cord; Sympathetic Nervous System; Time Factors | 2005 |
Essential role of the imidazoline moiety in the insulinotropic effect but not the KATP channel-blocking effect of imidazolines; a comparison of the effects of efaroxan and its imidazole analogue, KU14R.
Topics: Action Potentials; Animals; Benzofurans; Calcium; Cell Line; Cytosol; Imidazoles; Imidazolines; Insulin; Insulin Secretion; Insulin-Secreting Cells; Membrane Potentials; Mice; Mice, Mutant Strains; Patch-Clamp Techniques; Potassium Channel Blockers; Potassium Channels | 2005 |
Identification of the central imidazoline receptor subtype involved in modulation of halothane-epinephrine arrhythmias in rats.
Topics: Animals; Arrhythmias, Cardiac; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Epinephrine; Halothane; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Sprague-Dawley; Receptors, Drug | 2005 |
RX871024 reduces NO production but does not protect against pancreatic beta-cell death induced by proinflammatory cytokines.
Topics: Animals; Benzofurans; Cell Death; Cells, Cultured; Cytokines; Imidazoles; Indoles; Insulin; Insulin Secretion; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1; Mice; Mice, Obese; Nitric Oxide; Tumor Necrosis Factor-alpha | 2006 |
Possible role of NMDA receptors in antinociception induced by rilmenidine in mice in the formalin test.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Binding Sites; Binding, Competitive; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Imidazoles; Imidazoline Receptors; Male; Mice; Nervous System; Neurons, Afferent; Nociceptors; Oxazoles; Pain; Pain Measurement; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Rilmenidine; Yohimbine | 2007 |
Rhes expression in pancreatic beta-cells is regulated by efaroxan in a calcium-dependent process.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Calcium; Calcium Channel Blockers; Calcium Channels; Dihydropyridines; Glyburide; GTP-Binding Proteins; Humans; Hypoglycemic Agents; Imidazoles; Imidazolines; Insulin-Secreting Cells; RNA, Messenger; Transcription, Genetic | 2006 |
Involvement of I2-imidazoline binding sites in positive and negative morphine analgesia modulatory effects.
Topics: Adrenergic alpha-Antagonists; Analgesics, Opioid; Animals; Benzofurans; CHO Cells; Cricetinae; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Mice; Models, Molecular; Morphine; Naloxone; Narcotic Antagonists; Pain Measurement; Radioligand Assay; Reaction Time; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, Opioid, mu; Yohimbine | 2006 |
Sensitivity improvement of circular dichroism detection in HPLC by using a low-pass electronic noise filter: Application to the enantiomeric determination purity of a basic drug.
Topics: Adrenergic alpha-Antagonists; Benzofurans; Chromatography, High Pressure Liquid; Circular Dichroism; Imidazoles; Sensitivity and Specificity; Stereoisomerism | 2007 |
Validation of a method using an achiral liquid chromatography sorbent and a circular dichroism detector. Analysis of the efaroxan enantiomers.
Topics: Benzofurans; Calibration; Chromatography, High Pressure Liquid; Circular Dichroism; Imidazoles; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2007 |
Evidence for imidazoline receptors involvement in the agmatine antidepressant-like effect in the forced swimming test.
Topics: Agmatine; Animals; Antazoline; Antidepressive Agents; Benzofurans; Clonidine; Female; Imidazoles; Imidazoline Receptors; Male; Mice; Receptors, Adrenergic, alpha-2; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Swimming | 2007 |
Quantification of very low enantiomeric impurity of efaroxan using a dual cyclodextrin system by capillary electrophoresis.
Topics: Anions; Benzofurans; Buffers; Cyclodextrins; Electrophoresis, Capillary; Imidazoles; Molecular Structure; Sensitivity and Specificity; Stereoisomerism | 2007 |
Sympathoexcitation of moxonidine in the caudal ventrolateral medulla is dependent on I1-imidazoline receptors in anesthetized rats.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Drug Interactions; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System; Sympatholytics; Yohimbine | 2007 |
The imidazoline RX871024 induces death of proliferating insulin-secreting cells by activation of c-jun N-terminal kinase.
Topics: Animals; Benzofurans; Caspases; Cell Death; Cell Line; Cell Proliferation; Cytokines; Enzyme Activation; Humans; Imidazoles; Indoles; Insulin-Secreting Cells; JNK Mitogen-Activated Protein Kinases; Mice; Nitric Oxide | 2008 |
Effects of spinal alpha(2)-adrenoceptor and I(1)-imidazoline receptor activation on hindlimb movement induction in spinal cord-injured mice.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Benzofurans; Clonidine; Hindlimb; Imidazoles; Imidazoline Receptors; Male; Mice; Mice, Inbred Strains; Movement; Receptors, Adrenergic, alpha-2; Spinal Cord; Spinal Cord Injuries; Yohimbine | 2008 |
Caffeine and a selective adenosine A(2B) receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice.
Topics: Adrenergic alpha-Antagonists; Animals; Behavior, Animal; Benzene Derivatives; Benzofurans; Caffeine; Disease Models, Animal; Dose-Response Relationship, Drug; Hyperalgesia; Imidazoles; Injections, Intraperitoneal; Male; Mice; Neuroprotective Agents; Organoselenium Compounds; Pain Measurement; Phosphodiesterase Inhibitors; Pyrimidines; Triazoles; Xanthines | 2008 |
alpha2A-adrenoceptor antagonism increases insulin secretion and synergistically augments the insulinotropic effect of glibenclamide in mice.
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals; Atropine Derivatives; Benzofurans; Blood Glucose; Drug Synergism; Fasting; Glyburide; Hypoglycemic Agents; Imidazoles; Insulin; Insulin Secretion; Isoquinolines; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Muscarinic Antagonists; Naphthyridines; Phentolamine; Propranolol; Receptors, Adrenergic, alpha-2 | 2008 |
Imidazoline I(1) receptor-mediated reduction of muscle rigidity in the reserpine-treated murine model of Parkinson's disease.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Antiparkinson Agents; Benzazepines; Benzofurans; Clonidine; Disease Models, Animal; Dose-Response Relationship, Drug; Electromyography; Idazoxan; Imidazoles; Imidazoline Receptors; Injections, Intraperitoneal; Ligands; Male; Mice; Muscle Rigidity; Muscle, Skeletal; Parkinsonian Disorders; Reserpine; Time Factors; Yohimbine | 2008 |
Preventive mechanisms of agmatine against ischemic acute kidney injury in rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Agmatine; Animals; Benzofurans; Imidazoles; Imidazoline Receptors; Kidney Diseases; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sympathetic Nervous System; Veins; Yohimbine | 2009 |
Effect of moxonidine on the uveoscleral outflow: role of alpha2-adrenoceptors or i1 imidazoline receptors.
Topics: Administration, Topical; Adrenergic alpha-Antagonists; Animals; Aqueous Humor; Benzofurans; Bridged Bicyclo Compounds; Drug Synergism; Fluorescein-5-isothiocyanate; Heptanes; Imidazoles; Imidazoline Receptors; Prazosin; Rabbits; Receptors, Adrenergic, alpha-2; Sclera; Serum Albumin, Bovine; Uvea; Yohimbine | 2009 |
Low dose of moxonidine within the rostral ventrolateral medulla improves the baroreflex sensitivity control of sympathetic activity in hypertensive rat.
Topics: Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Baroreflex; Benzofurans; Blood Pressure; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; Iontophoresis; Kidney; Medulla Oblongata; Microinjections; Neurons; Rats; Rats, Inbred SHR; Sympathetic Nervous System; Synaptic Potentials; Yohimbine | 2009 |
Pharmacological stimulation and inhibition of insulin secretion in mouse islets lacking ATP-sensitive K+ channels.
Topics: Animals; Benzofurans; Calcium; Cytosol; Diazoxide; Female; Imidazoles; Imidazolines; Insulin; Insulin Secretion; Insulin-Secreting Cells; KATP Channels; Mice; Mice, Knockout; Phentolamine; Pinacidil; Potassium Channels; Tolbutamide | 2010 |
Imidazoline receptor antisera-selected/Nischarin regulates the effect of agmatine on the development of morphine dependence.
Topics: Adenosine Monophosphate; Adrenergic alpha-Antagonists; Agmatine; Animals; Benzofurans; Cells, Cultured; Drug Interactions; Gene Knockdown Techniques; Hippocampus; Imidazoles; Imidazoline Receptors; Immune Sera; Intracellular Signaling Peptides and Proteins; Male; Mice; Mice, Inbred BALB C; Morphine Dependence; Neurons; Proto-Oncogene Proteins c-fos; RNA, Small Interfering; Substance Withdrawal Syndrome | 2012 |
Stimulatory effect of allantoin on imidazoline I₁ receptors in animal and cell line.
Topics: Allantoin; Animals; Anticholesteremic Agents; Antihypertensive Agents; Benzofurans; Diet, High-Fat; Fatty Liver; Hep G2 Cells; Humans; Hypercholesterolemia; Hypertriglyceridemia; Hypolipidemic Agents; Imidazoles; Imidazoline Receptors; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cytoplasmic and Nuclear; Receptors, LDL; Up-Regulation | 2012 |
Improvement of hyperphagia by activation of cerebral I(1)-imidazoline receptors in streptozotocin-induced diabetic mice.
Topics: Animals; Benzofurans; Cerebrum; Diabetes Mellitus, Type 1; Disease Models, Animal; Eating; Female; Humans; Hyperphagia; Hypothalamus; Imidazoles; Imidazoline Receptors; Male; Mice; Mice, Inbred BALB C; Neuropeptide Y; Oxazoles; Rilmenidine; Streptozocin | 2012 |
Mechanisms of antihyperglycaemic action of efaroxan in mice: time for reappraisal of α2A-adrenergic antagonism in the treatment of type 2 diabetes?
Topics: Adrenergic alpha-2 Receptor Antagonists; Adrenergic alpha-Antagonists; Animals; Antihypertensive Agents; Benzofurans; Brimonidine Tartrate; Calcium; Cells, Cultured; Diabetes Mellitus, Type 2; Diazoxide; Female; Hyperglycemia; Imidazoles; Insulin; Insulin-Secreting Cells; KATP Channels; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Patch-Clamp Techniques; Quinoxalines; Yohimbine | 2012 |
Potentiation of oxycodone antinociception in mice by agmatine and BMS182874 via an imidazoline I2 receptor-mediated mechanism.
Topics: Agmatine; Analgesics, Opioid; Animals; Benzofurans; Dansyl Compounds; Drug Synergism; Imidazoles; Imidazoline Receptors; Male; Mice; Oxycodone; Pain Measurement | 2013 |
I1 imidazoline receptor: novel potential cytoprotective target of TVP1022, the S-enantiomer of rasagiline.
Topics: Animals; Benzofurans; Binding Sites; Blotting, Western; Cardiotonic Agents; Dose-Response Relationship, Drug; Imidazoles; Imidazoline Receptors; In Vitro Techniques; Indans; Inhibitory Concentration 50; Mitogen-Activated Protein Kinase 1; Myocytes, Cardiac; PC12 Cells; Rats; Signal Transduction | 2012 |
Changes of imidazoline receptors in spontaneously hypertensive rats.
Topics: Agmatine; Animals; Antihypertensive Agents; Aorta, Thoracic; Benzofurans; Blood Pressure; Blotting, Western; Cyclic AMP-Dependent Protein Kinases; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium, Vascular; Humans; Hypertension; Imidazoles; Imidazoline Receptors; KATP Channels; Male; Potassium Channel Blockers; Protein Kinase Inhibitors; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Up-Regulation; Vasodilation; Vasodilator Agents | 2013 |
Imidazoline-1 receptor ligands as apoptotic agents: pharmacophore modeling and virtual docking study.
Topics: Antineoplastic Agents; Apoptosis; Benzofurans; Cell Proliferation; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Imidazoles; Imidazoline Receptors; K562 Cells; Ligands; Models, Molecular; Molecular Docking Simulation; Oxazoles; Quantitative Structure-Activity Relationship; Rilmenidine; Tumor Cells, Cultured | 2013 |
Stereo-selective inhibition of spinal morphine tolerance and hyperalgesia by an ultra-low dose of the alpha-2-adrenoceptor antagonist efaroxan.
Topics: Adrenergic alpha-2 Receptor Agonists; Adrenergic alpha-Antagonists; Analgesics; Animals; Benzofurans; Clonidine; Drug Tolerance; Hot Temperature; Hyperalgesia; Imidazoles; Injections, Spinal; Male; Morphine; Pain; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Touch | 2013 |
Evidences for the agmatine involvement in antidepressant like effect of bupropion in mouse forced swim test.
Topics: Agmatine; Animals; Antidepressive Agents; Arginine; Benzofurans; Biguanides; Bupropion; Clonidine; Dose-Response Relationship, Drug; Drug Interactions; Eflornithine; Guanidines; Idazoxan; Imidazoles; Immobility Response, Tonic; Injections, Intraventricular; Male; Mice; Motor Activity | 2013 |
Protective effect of moxonidine on ischemia/reperfusion-induced acute kidney injury through α2/imidazoline I1 receptor.
Topics: Acute Kidney Injury; Animals; Benzofurans; Cytoprotection; Imidazoles; Imidazoline Receptors; Kidney; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Sympathetic Nervous System; Veins | 2013 |
Alpha-2 adrenoceptors and imidazoline receptors in cardiomyocytes mediate counterbalancing effect of agmatine on NO synthesis and intracellular calcium handling.
Topics: Adrenergic alpha-2 Receptor Agonists; Agmatine; Animals; Benzofurans; Calcium Signaling; Cells, Cultured; Imidazoles; Imidazoline Receptors; Myocytes, Cardiac; Nitric Oxide; Nitric Oxide Synthase Type III; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Adrenergic, alpha-2 | 2014 |
Modulation of imidazoline I2 binding sites by CR4056 relieves postoperative hyperalgesia in male and female rats.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Binding Sites; Drug Synergism; Female; Hyperalgesia; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Morphine; Naloxone; Narcotic Antagonists; Pain, Postoperative; Quinazolines; Rats, Sprague-Dawley; Yohimbine | 2014 |
α2-Adrenergic blockade mimics the enhancing effect of chronic stress on breast cancer progression.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-2 Receptor Antagonists; Animals; Benzofurans; Cell Proliferation; Disease Progression; Female; Imidazoles; Mammary Neoplasms, Experimental; Mice; Neoplasm Metastasis; Prazosin; Restraint, Physical; Signal Transduction; Stress, Physiological; Stress, Psychological | 2015 |
Immunodetection and subcellular distribution of imidazoline receptor proteins with three antibodies in mouse and human brains: Effects of treatments with I1- and I2-imidazoline drugs.
Topics: Adult; Animals; Antibodies; Benzofurans; Binding Sites; Brain; Cell Membrane; Cytosol; Female; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Imidazolines; Male; Mice; Styrenes; Up-Regulation | 2015 |
Insulinotropic compounds decrease endothelial cell survival.
Topics: Benzofurans; Carbamates; Cell Proliferation; Cell Survival; Cells, Cultured; Dimethyl Sulfoxide; Glucose; Glyburide; Human Umbilical Vein Endothelial Cells; Humans; Hypoglycemic Agents; Imidazoles; Indoles; Nitric Oxide; Piperidines; Vascular Endothelial Growth Factor A | 2016 |
Centrally acting drug moxonidine decreases reactive oxygen species via inactivation of the phosphoinositide-3 kinase signaling in the rostral ventrolateral medulla in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Benzofurans; Disease Models, Animal; Hypertension; Imidazoles; Male; Medulla Oblongata; Phosphatidylinositol 3-Kinases; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Reactive Oxygen Species; Signal Transduction | 2016 |
Circulatory effect of TCS-80, a new imidazoline compound, in rats.
Topics: Animals; Benzofurans; Blood Pressure; Heart Rate; Hypotension; Idazoxan; Imidazoles; Imidazolidines; Imidazoline Receptors; Imidazolines; Indazoles; Male; Rats; Receptors, Adrenergic, alpha-2 | 2016 |
Inhibitory effects of imidazoline receptor ligands on basal and kainic acid-induced neurotoxic signalling in mice.
Topics: Animals; Benzofurans; Cerebral Cortex; Cyclin-Dependent Kinase 5; Glutamic Acid; Hippocampus; Idazoxan; Imidazoles; Imidazoline Receptors; Kainic Acid; Ligands; Male; Mice; Neurodegenerative Diseases; Neuroprotective Agents; Styrenes; Time Factors | 2016 |
Dissociation between morphine-induced spinal gliosis and analgesic tolerance by ultra-low-dose α2-adrenergic and cannabinoid CB1-receptor antagonists.
Topics: Adrenergic alpha-2 Receptor Antagonists; Analgesics; Analgesics, Opioid; Animals; Benzofurans; Cannabinoid Receptor Antagonists; Cannabinoids; Dose-Response Relationship, Drug; Drug Tolerance; Gliosis; Imidazoles; Injections, Spinal; Male; Morphine; Neuroglia; Norepinephrine; Pain Measurement; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Spine | 2018 |
Responsiveness of α2-adrenoceptor/I1-imidazoline receptor in the rostral ventrolateral medulla to cardiovascular regulation is enhanced in conscious spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Benzofurans; Blood Pressure; Blood Pressure Determination; Clonidine; Consciousness; Heart Rate; Hypertension; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Medulla Oblongata; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Adrenergic, alpha-2; Sympathetic Nervous System | 2019 |
[ADRENERGIC AND IMIDAZOLINE MECHANISMS OF CIRCULATION CENTRAL REGULATION IN RATS OF DIFFERENT LINES].
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Baroreflex; Benzofurans; Blood Pressure; Brain; Clonidine; Heart Rate; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Inbred SHR; Rats, Wistar; Sympathetic Nervous System; Yohimbine | 2016 |
Agmatine modulates spontaneous activity in neurons of the rat medial habenular complex-a relevant mechanism in the pathophysiology and treatment of depression?
Topics: Action Potentials; Agmatine; Animals; Benzofurans; Depression; Female; Habenula; Humans; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Middle Aged; Neurons; Rats, Wistar; Ureohydrolases | 2018 |
Agmatine Inhibits Behavioral Sensitization to Ethanol Through Imidazoline Receptors.
Topics: Agmatine; Animals; Arginine; Benzofurans; Biguanides; Central Nervous System Sensitization; Dose-Response Relationship, Drug; Drug Interactions; Ethanol; Guanidines; Idazoxan; Imidazoles; Imidazoline Receptors; Infusions, Intraventricular; Male; Mice; Microinjections; Motor Activity | 2019 |
Deciphering Imidazoline Off-targets by Fishing in the Class A of GPCR field.
Topics: Animals; Area Under Curve; Benzofurans; CHO Cells; Cricetulus; Humans; Idazoxan; Imidazoles; Imidazolines; Ligands; Molecular Docking Simulation; Receptors, Adrenergic, alpha-2; Receptors, G-Protein-Coupled; Reproducibility of Results | 2020 |
Effects of imidazoline agents in a rat conditioned place preference model of addiction.
Topics: Agmatine; Analgesics, Opioid; Animals; Benzofurans; Conditioning, Psychological; Drug Interactions; Idazoxan; Imidazoles; Imidazoline Receptors; Male; Rats; Rats, Wistar; Time Factors; Tramadol | 2022 |