edoxaban and kirenol

edoxaban has been researched along with kirenol* in 1 studies

Other Studies

1 other study(ies) available for edoxaban and kirenol

ArticleYear
Semisynthesis of epoxy-pimarane diterpenoids from kirenol and their FXa inhibition activities.
    Bioorganic & medicinal chemistry, 2019, 04-01, Volume: 27, Issue:7

    Kirenol is one of the biologically active diterpenoids from Siegesbeckia pubescens. In terms of the high content and typical structure, many ent-diterpenoids separated from S. pubescens were presumed to be biologically related to kirenol. Among them, epoxy-pimarane diterpenoids are belonging to a special family of naturally occurring compounds that attracted our attentions on their putative biosynthesis pathway and biological activities. Here, we designed and synthesized two known 14,16-epoxy-pimarane diterpenoids (2 and 3) and five 8,15-epoxy-pimarane diterpenoids (4-8) from kirenol. Their absolute structures were determined by 1D and 2D NMR data and the absolute configurations of 4 were confirmed by X-ray crystallographic data. Their inhibition effects on factor Xa (FXa) were evaluated to assess the potentiality of epoxy-pimarane diterpenoids as FXa inhibitor agents.

    Topics: Abietanes; Crystallography, X-Ray; Diterpenes; Dose-Response Relationship, Drug; Epoxy Compounds; Factor Xa; Factor Xa Inhibitors; Humans; Molecular Structure; Structure-Activity Relationship

2019