Page last updated: 2024-08-17

edetic acid and acetylcysteine

edetic acid has been researched along with acetylcysteine in 41 studies

Research

Studies (41)

TimeframeStudies, this research(%)All Research%
pre-199013 (31.71)18.7374
1990's4 (9.76)18.2507
2000's7 (17.07)29.6817
2010's15 (36.59)24.3611
2020's2 (4.88)2.80

Authors

AuthorsStudies
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Abouelhassan, Y; Bai, F; Burch, GM; Garrison, AT; Huigens, RW; Jin, S; Kallifidas, D; Luesch, H; Nguyen, MT; Norwood, VM; Rolfe, M1
Abouelhassan, Y; Garrison, AT; Huigens, RW; Jin, S; Kallifidas, D; Kim, YS; Luesch, H; Tan, H1
Gerhardt, W; Gruber, W; Waldenström, J1
Ellison, A; Poirier, R1
Sandifort, CR1
Gruber, W1
Corbella, J; Domingo, JL; Llobet, JM2
Kägi, JH; Pande, J; Vasák, M1
Lieberman, J1
Sugar, A; Waltman, SR1
Bateman, DN; Rawlins, MD; Woodhouse, KW1
Henderson, AR; Nealon, DA; Pettit, SM1
Dubowitz, V; Heckmatt, J; Moss, DW; Parmar, C; Sewry, C; Whitaker, KB; Wikowski, J1
Itoh, M; Joh, T; Seno, K; Yokoyama, Y1
Aabech, J; Andersen, JT1
Hinze, H; Lenz, AG; Maier, KL; Meyer, B1
Altindag, ZZ; Fuchs, D; Wachter, H; Wede, I; Widner, B1
Lin, MC; Ou, CC; Tsao, SM; Yin, MC1
Andrew, SE; Blalock, TD; Brooks, DE; Gelatt, KN; Kallberg, ME; Komaromy, AM; Lassaline, ME; Ollivier, FJ; Schultz, GS; Stevens, GR; van Setten, GB1
Hazell, AS; Kennedy, G; Norenberg, MD; Normandin, L; Yi, JH1
Kuo, YM; Wu, Z; Yang, Y; Zhou, B1
Doroshow, JH1
Bartosz, G; Coulon, J; Dossot, M; Leroy, P; Marchand, S; Matoub, L1
Abraham, L; Ates, B; Ercal, N1
Beach, DG; Gabryelski, W; Manderville, RA; Witham, AA1
Caleo, M; Cecchini, M; Signore, G; Tonazzini, I; Voccoli, V1
Borlee, BR; Borlee, GI; Ferris, RA; Hennet, ML; Loncar, KD; McCue, PM1
Kimmitt, BA; Moore, GE; Stiles, J1
Fujimoto, K; Fujita, M; Horie, N; Kasahara, T; Katsuoka, Y; Kawakami, T; Kojima, H; Kojima, K; Kurokawa, Y; Kusakari, K; Ono, A; Sugawara, T; Tahara, Y; Tanabe, H; Wakabayashi, K; Watanabe, S; Yamamoto, Y; Yokoyama, H1
Chan, WY; Hickey, EE; Hill, PB; Khazandi, M; Page, SW; Trott, DJ1
Dear, J1
Ignarro, LJ; Jynge, P; Karlsson, JOG; Lundström, I1
Black, P; Dear, JW; Gallagher, B; Grahamslaw, J; Henriksen, D; Lee, RJ; Morrison, EE; O'Brien, R; Oatey, K; Oosthuyzen, W; Weir, CJ1
Karlsson, JOG1
Dear, JW1
Chan, WY; Hickey, EE; Hill, PB; Page, SW; Trott, DJ1
Freeman, WE; Mullins, ME; Yeager, LH1
Akakpo, JY; Jaeschke, H; Ramachandran, A1

Reviews

4 review(s) available for edetic acid and acetylcysteine

ArticleYear
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
Collagenase inhibitors: rationale for their use in treating corneal ulceration.
    International ophthalmology clinics, 1975,Winter, Volume: 15, Issue:4

    Topics: Acetylcysteine; alpha 1-Antitrypsin; alpha-Macroglobulins; Animals; Calcium; Corneal Ulcer; Cyclic AMP; Cysteine; Disease Models, Animal; Edetic Acid; Humans; Microbial Collagenase; Protease Inhibitors; Steroids; Tropocollagen; Zinc Radioisotopes

1975
Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review.
    Clinical toxicology (Philadelphia, Pa.), 2020, Volume: 58, Issue:12

    Topics: Acetaminophen; Acetylcysteine; Acidosis; Animals; Antidotes; Cimetidine; Drug Overdose; Edetic Acid; Fomepizole; Humans; Mitochondria; Pyridoxal Phosphate

2020
Novel strategies for the treatment of acetaminophen hepatotoxicity.
    Expert opinion on drug metabolism & toxicology, 2020, Volume: 16, Issue:11

    Topics: Acetaminophen; Acetylcysteine; Animals; Antidotes; Chemical and Drug Induced Liver Injury; Drug Overdose; Edetic Acid; Fomepizole; Hepatocytes; Humans; Liver Failure, Acute; Pyridoxal Phosphate

2020

Trials

2 trial(s) available for edetic acid and acetylcysteine

ArticleYear
Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N-acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: study protocol for a randomi
    Trials, 2019, Jan-08, Volume: 20, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Chemical and Drug Induced Liver Injury; Clinical Trials Data Monitoring Committees; Clinical Trials, Phase I as Topic; Data Interpretation, Statistical; Drug Overdose; Drug Therapy, Combination; Edetic Acid; Female; Humans; Male; Outcome Assessment, Health Care; Pyridoxal Phosphate; Randomized Controlled Trials as Topic; Research Design

2019
Principal results of a randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with a 12 h regimen of N-acetylcysteine for paracetamol overdose (POP trial).
    EBioMedicine, 2019, Volume: 46

    Topics: Acetaminophen; Acetylcysteine; Adult; Biomarkers; Chemical and Drug Induced Liver Injury; Drug Interactions; Drug Overdose; Edetic Acid; Female; Humans; Male; Protective Agents; Pyridoxal Phosphate; Time Factors; Young Adult

2019

Other Studies

35 other study(ies) available for edetic acid and acetylcysteine

ArticleYear
Structure-Activity Relationships of a Diverse Class of Halogenated Phenazines That Targets Persistent, Antibiotic-Tolerant Bacterial Biofilms and Mycobacterium tuberculosis.
    Journal of medicinal chemistry, 2016, 04-28, Volume: 59, Issue:8

    Topics: Biofilms; Carbon-13 Magnetic Resonance Spectroscopy; Drug Resistance, Bacterial; Drug Screening Assays, Antitumor; Halogens; HeLa Cells; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Phenazines; Proton Magnetic Resonance Spectroscopy; Structure-Activity Relationship

2016
An Efficient Buchwald-Hartwig/Reductive Cyclization for the Scaffold Diversification of Halogenated Phenazines: Potent Antibacterial Targeting, Biofilm Eradication, and Prodrug Exploration.
    Journal of medicinal chemistry, 2018, 05-10, Volume: 61, Issue:9

    Topics: Anti-Bacterial Agents; Biofilms; Cyclization; Halogenation; HeLa Cells; Humans; Methicillin-Resistant Staphylococcus aureus; Microbial Sensitivity Tests; Phenazines

2018
EDTA effect on creatine kinase (CK) and on the SCE reagent.
    Scandinavian journal of clinical and laboratory investigation, 1979, Volume: 39, Issue:8

    Topics: Acetylcysteine; Calcium; Chelating Agents; Creatine Kinase; Drug Stability; Edetic Acid; Ferric Compounds; In Vitro Techniques; Indicators and Reagents; Isoenzymes; Mercaptoethanol; Scandinavian and Nordic Countries; Sulfhydryl Compounds; Time Factors

1979
Therapeutic effects of heparin on Pseudomonas-induced corneal ulceration.
    American journal of ophthalmology, 1976, Volume: 82, Issue:4

    Topics: Acetylcysteine; Administration, Topical; Adult; Animals; Colistin; Corneal Ulcer; Drug Therapy, Combination; Edetic Acid; Gentamicins; Heparin; Humans; Male; Middle Aged; Polymyxins; Pseudomonas aeruginosa; Pseudomonas Infections; Rabbits

1976
Effects of ethylenediaminetetraacetate on "CK-NAC" reagent stability and measured creatine kinase activities.
    Clinical chemistry, 1977, Volume: 23, Issue:11

    Topics: Acetylcysteine; Creatine Kinase; Drug Stability; Edetic Acid; Enzyme Activation; Humans; Indicators and Reagents; Methods

1977
Inhibition of creatine kinase activity by Ca2+ and reversing effect of ethylenediaminetetraacetate.
    Clinical chemistry, 1978, Volume: 24, Issue:1

    Topics: Acetylcysteine; Animals; Calcium; Creatine Kinase; Edetic Acid; Humans; Isoenzymes

1978
Comparative effects of repeated parenteral administration of several chelators on the distribution and excretion of cobalt.
    Research communications in chemical pathology and pharmacology, 1988, Volume: 60, Issue:2

    Topics: Acetylcysteine; Animals; Chelating Agents; Cobalt; Edetic Acid; Glutathione; Injections, Intraperitoneal; Male; Pentetic Acid; Rats; Rats, Inbred Strains; Succimer

1988
Comparison of the effectiveness of several chelators after single administration on the toxicity, excretion and distribution of cobalt.
    Archives of toxicology, 1986, Volume: 58, Issue:4

    Topics: Acetylcysteine; Animals; Chelating Agents; Cobalt; Cysteine; Edetic Acid; Glutathione; Male; Mice; Pentetic Acid; Tissue Distribution

1986
Interaction of lysine residues with the metal thiolate clusters in metallothionein.
    Biochemistry, 1985, Nov-05, Volume: 24, Issue:23

    Topics: Acetylcysteine; Amino Acids; Animals; Cadmium; Circular Dichroism; Edetic Acid; Kinetics; Liver; Lysine; Metallothionein; Nitrobenzenes; Protein Conformation; Rats; Trinitrobenzenesulfonic Acid; Zinc

1985
The appropriate use of mucolytic agents.
    The American journal of medicine, 1970, Volume: 49, Issue:1

    Topics: Acetylcysteine; Anti-Bacterial Agents; Ascorbic Acid; Bronchi; Bronchitis; Bronchodilator Agents; Deoxyribonucleases; DNA; Edetic Acid; Epithelium; Glycosaminoglycans; Humans; Mucus; Peptide Hydrolases; Respiratory Therapy; Sputum; Trachea; Urea; Viscosity

1970
Corneal toxicity of collagenase inhibitors.
    Investigative ophthalmology, 1973, Volume: 12, Issue:10

    Topics: Acetylcysteine; Animals; Calcium; Cornea; Corneal Opacity; Cysteine; Edema; Edetic Acid; Hypertonic Solutions; Injections; Microbial Collagenase; Ophthalmic Solutions; Rabbits; Sodium; Sodium Chloride

1973
Adverse reactions to N-acetylcysteine.
    Human toxicology, 1984, Volume: 3, Issue:5

    Topics: Acetaminophen; Acetylcysteine; Adolescent; Adult; Aged; Edetic Acid; Female; Humans; Male; Skin Tests; Time Factors; Urticaria

1984
Activation of human creatine kinase isoenzymes by pH and various sulfhydryl and chelating agents.
    Clinical chemistry, 1981, Volume: 27, Issue:3

    Topics: Acetylcysteine; Chelating Agents; Creatine Kinase; Edetic Acid; Egtazic Acid; Enzyme Activation; Glycerol; Humans; Hydrogen-Ion Concentration; Isoenzymes; Mercaptoethanol; Sulfhydryl Compounds

1981
Activity of creatine kinase in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, determined by the "European" recommended method with NAC-EDTA activation.
    Clinica chimica acta; international journal of clinical chemistry, 1981, Oct-26, Volume: 116, Issue:2

    Topics: Acetylcysteine; Adolescent; Adult; Creatine Kinase; Edetic Acid; Female; Fetal Blood; Genetic Carrier Screening; Humans; Kinetics; Middle Aged; Muscular Dystrophies; Pregnancy; Reference Values

1981
Role of mucus in gastric mucosal injury induced by local ischemia/reperfusion.
    The Journal of laboratory and clinical medicine, 1995, Volume: 126, Issue:3

    Topics: Acetylcysteine; Alcian Blue; Animals; Chromium Radioisotopes; Diterpenes; Edetic Acid; Gastric Mucosa; Hexosamines; Ischemia; Male; Mucus; Periodic Acid-Schiff Reaction; Rats; Rats, Sprague-Dawley; Reperfusion Injury

1995
Treatment of cystine stones: combined approach using open pyelolithotomy, percutaneous pyelolithotripsy, extracorporeal shock wave lithotripsy and chemolysis.
    Scandinavian journal of urology and nephrology, 1993, Volume: 27, Issue:3

    Topics: Acetylcysteine; Adolescent; Adult; Combined Modality Therapy; Cystine; Cystinuria; Edetic Acid; Female; Humans; Kidney Calculi; Kidney Pelvis; Lithotripsy; Stents; Therapeutic Irrigation; Tromethamine

1993
Metal-catalyzed inactivation of bovine glucose-6-phosphate dehydrogenase--role of thiols.
    FEBS letters, 1996, Oct-28, Volume: 396, Issue:1

    Topics: Acetylcysteine; Adenosine Diphosphate; Animals; Cattle; Cysteine; Dipeptides; Edetic Acid; Enzyme Activation; Glucosephosphate Dehydrogenase; Glutathione; Hydrogen Peroxide; Hypoxanthine; Iron; Metals; Oxidation-Reduction; Sulfhydryl Compounds; Xanthine Oxidase

1996
Inhibition of xanthine oxidase by pterins.
    Free radical research, 1998, Volume: 29, Issue:4

    Topics: Acetylcysteine; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Edetic Acid; Ferric Compounds; Formazans; Hydrogen-Ion Concentration; Nitroblue Tetrazolium; Oxidation-Reduction; Pterins; Spectrophotometry, Ultraviolet; Superoxide Dismutase; Superoxides; Time Factors; Uric Acid; Xanthine; Xanthine Oxidase

1998
Protective action on human LDL against oxidation and glycation by four organosulfur compounds derived from garlic.
    Lipids, 2003, Volume: 38, Issue:3

    Topics: Acetylcysteine; Allyl Compounds; Amphotericin B; Antioxidants; Chelating Agents; Copper; Cysteine; Disulfides; Edetic Acid; Garlic; Glucose; Humans; Lipoproteins, LDL; Oxidation-Reduction; Sulfides; Sulfur Compounds; Superoxides; Xanthine Oxidase

2003
Evaluation of various compounds to inhibit activity of matrix metalloproteinases in the tear film of horses with ulcerative keratitis.
    American journal of veterinary research, 2003, Volume: 64, Issue:9

    Topics: Acetylcysteine; alpha 1-Antitrypsin; Animals; Corneal Ulcer; Doxycycline; Edetic Acid; Electrophoresis; Horse Diseases; Horses; Hydroxamic Acids; Image Processing, Computer-Assisted; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Protease Inhibitors; Tears

2003
Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment.
    Neuroscience letters, 2006, Apr-03, Volume: 396, Issue:3

    Topics: Acetylcysteine; Alzheimer Disease; Analysis of Variance; Animals; Antioxidants; Astrocytes; Cerebral Cortex; Chelating Agents; Disease Models, Animal; Drug Interactions; Edetic Acid; Male; Manganese; Rats; Rats, Sprague-Dawley; Time Factors

2006
Dietary rescue of fumble--a Drosophila model for pantothenate-kinase-associated neurodegeneration.
    Journal of inherited metabolic disease, 2005, Volume: 28, Issue:6

    Topics: Acetylcysteine; Adenosine Triphosphate; Animal Feed; Animals; Ascorbic Acid; Carnitine; Cloning, Molecular; Creatine; Diet; Disease Models, Animal; Drosophila; Drosophila melanogaster; Edetic Acid; Ginkgo biloba; Heterozygote; Humans; Inosine; Iron; Mutation; Neurodegenerative Diseases; Phenotype; Phosphotransferases (Alcohol Group Acceptor); Transgenes; Vitamin E

2005
Redox modulation of chemotherapy-induced tumor cell killing and normal tissue toxicity.
    Journal of the National Cancer Institute, 2006, Feb-15, Volume: 98, Issue:4

    Topics: Acetylcysteine; Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Line, Tumor; Colonic Neoplasms; Drug Synergism; Edetic Acid; Humans; Hydrogen Peroxide; Leukocytes; Mice; Oxidation-Reduction; Pyridoxal Phosphate; Reactive Oxygen Species

2006
Potential relationship between glutathione metabolism and flocculation in the yeast Kluyveromyces lactis.
    FEMS yeast research, 2007, Volume: 7, Issue:1

    Topics: Acetylcysteine; Culture Media; Edetic Acid; Flocculation; Galactose; Glutathione; Glutathione Transferase; Kluyveromyces

2007
Antioxidant and free radical scavenging properties of N-acetylcysteine amide (NACA) and comparison with N-acetylcysteine (NAC).
    Free radical research, 2008, Volume: 42, Issue:4

    Topics: Acetylcysteine; Antioxidants; beta Carotene; Biphenyl Compounds; Chelating Agents; Dose-Response Relationship, Drug; Edetic Acid; Free Radical Scavengers; Free Radicals; Humans; Hydrazines; Hydrogen Peroxide; Linoleic Acid; Metals; Picrates; Sulfhydryl Compounds

2008
Hydroxyl radical-induced oxidation of a phenolic C-linked 2'-deoxyguanosine adduct yields a reactive catechol.
    Chemical research in toxicology, 2012, Feb-20, Volume: 25, Issue:2

    Topics: Acetylcysteine; Catechols; Copper; Deoxyguanosine; DNA Adducts; Edetic Acid; Ferrous Compounds; Hydrogen Peroxide; Hydroxyl Radical; Phenols

2012
Role of extracellular calcium and mitochondrial oxygen species in psychosine-induced oligodendrocyte cell death.
    Cell death & disease, 2014, Nov-20, Volume: 5

    Topics: Acetylcysteine; Antioxidants; Calcium; Calcium Chelating Agents; Cell Death; Cell Line; Cell Survival; Culture Media; Cytosol; Edetic Acid; Humans; Mitochondria; Oligodendroglia; Psychosine; Reactive Oxygen Species

2014
In Vitro Efficacy of Nonantibiotic Treatments on Biofilm Disruption of Gram-Negative Pathogens and an In Vivo Model of Infectious Endometritis Utilizing Isolates from the Equine Uterus.
    Journal of clinical microbiology, 2016, Volume: 54, Issue:3

    Topics: Acetylcysteine; Animals; Anti-Infective Agents; Biofilms; Biomass; Disease Models, Animal; Edetic Acid; Endometritis; Female; Gram-Negative Bacteria; Horses; Hydrogen Peroxide; Luminescent Measurements; Microbial Viability; Staining and Labeling; Uterus

2016
Comparison of the efficacy of various concentrations and combinations of serum, ethylenediaminetetraacetic acid, tetracycline, doxycycline, minocycline, and N-acetylcysteine for inhibition of collagenase activity in an in vitro corneal degradation model.
    American journal of veterinary research, 2018, Volume: 79, Issue:5

    Topics: Acetylcysteine; Animals; Anti-Bacterial Agents; Collagenases; Cornea; Corneal Diseases; Disease Models, Animal; Dogs; Doxycycline; Edetic Acid; Horses; Matrix Metalloproteinase Inhibitors; Minocycline; Serum; Tetracycline

2018
Cause of and countermeasures for oxidation of the cysteine-derived reagent used in the amino acid derivative reactivity assay.
    Journal of applied toxicology : JAT, 2019, Volume: 39, Issue:2

    Topics: Acetylcysteine; Allergens; Animal Testing Alternatives; Animals; Biological Assay; Copper; Edetic Acid; Ferric Compounds; Models, Chemical; Oxidation-Reduction; Skin

2019
In vitro antimicrobial activity of seven adjuvants against common pathogens associated with canine otitis externa.
    Veterinary dermatology, 2019, Volume: 30, Issue:2

    Topics: Acetylcysteine; Adjuvants, Pharmaceutic; Animals; Anti-Infective Agents; Bacteria; Dogs; Drug Resistance, Multiple, Bacterial; Drug Synergism; Edetic Acid; Fungi; Laurates; Malassezia; Microbial Sensitivity Tests; Monoglycerides; Otitis Externa; Pseudomonas aeruginosa; Staphylococcus

2019
Letter in response to: "Randomised open label exploratory, safety and tolerability study with calmangafodipir in patients treated with the 12-h regimen of N acetylcysteine for paracetamol overdose-the PP100-01 for Overdose of Paracetamol (POP) trial: stud
    Trials, 2019, 06-24, Volume: 20, Issue:1

    Topics: Acetaminophen; Acetylcysteine; Drug Overdose; Edetic Acid; Humans; Pyridoxal Phosphate; Research Design

2019
Gastrointestinal AEs seen in the POP trial due to SOD mimetic activity of calmangafodipir?
    EBioMedicine, 2019, Volume: 47

    Topics: Acetaminophen; Acetylcysteine; Edetic Acid; Humans; Pyridoxal Phosphate; Superoxide Dismutase

2019
Gastrointestinal AEs seen in the POP trial due to SOD mimetic activity of calmangafodipir? - Authors' reply.
    EBioMedicine, 2019, Volume: 47

    Topics: Acetaminophen; Acetylcysteine; Edetic Acid; Humans; Pyridoxal Phosphate; Superoxide Dismutase

2019
Biofilm production by pathogens associated with canine otitis externa, and the antibiofilm activity of ionophores and antimicrobial adjuvants.
    Journal of veterinary pharmacology and therapeutics, 2019, Volume: 42, Issue:6

    Topics: Acetylcysteine; Animals; Anti-Infective Agents; Bacteria; Biofilms; Dog Diseases; Dogs; Edetic Acid; Enrofloxacin; Ionophores; Microbial Sensitivity Tests; Monensin; Otitis Externa; Pyrans

2019