edatrexate has been researched along with levoleucovorin in 11 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (9.09) | 18.7374 |
| 1990's | 10 (90.91) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hong, WK; Lee, JS; Murphy, WK; Pang, A; Shirinian, MH | 1 |
| Bertino, JR; Li, WW; Lin, JT; Schweitzer, BI | 1 |
| DeGraw, JI; Schmid, FA; Sirotnak, FM | 1 |
| Jansen, G; Jolivet, J; Peters, GJ; Pinard, MF; Schornagel, JH | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Benner, SE; Dimery, IW; Esparaz, B; Frenning, D; Guillory-Perez, C; Hong, WK; Huber, MH; Lippman, SM; Shirinian, M | 1 |
| Jansen, G; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Otter, GM; Schmid, FA; Sirotnak, FM | 1 |
| Holmes, FA | 1 |
| Bertino, JR; Densmore, CL; Fleisher, M; Grant, SC; Heelan, RT; Kris, MG; Krol, G; Miller, VA; Pfister, DG; Pisters, KM; Rigas, JR; Sirotnak, FM; Tong, W; Tyson, LB | 1 |
| Belani, CP; Green, MR; Herndon, JE; Kindler, HL; Suzuki, Y; Vogelzang, NJ | 1 |
1 review(s) available for edatrexate and levoleucovorin
| Article | Year |
|---|---|
Paclitaxel combination therapy in the treatment of metastatic breast cancer: a review.
Topics: Aminopterin; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Synergism; Drugs, Investigational; Female; Fluorouracil; Genetic Therapy; Humans; Leucovorin; Neoplasm Metastasis; Oncogenes; Paclitaxel; Radiotherapy, Adjuvant | 1996 |
3 trial(s) available for edatrexate and levoleucovorin
| Article | Year |
|---|---|
Phase II study of carboplatin and edatrexate (10-EdAM) with leucovorin rescue for patients with recurrent squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local | 1994 |
High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer.
Topics: Administration, Oral; Adult; Aged; Aminopterin; Antineoplastic Agents; Drug Interactions; Drug Monitoring; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasms | 1996 |
Edatrexate (10-ethyl-deaza-aminopterin) (NSC #626715) with or without leucovorin rescue for malignant mesothelioma. Sequential phase II trials by the cancer and leukemia group B.
Topics: Aminopterin; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Leucovorin; Leukemia; Male; Mesothelioma; Middle Aged; Pleural Neoplasms; Survival Rate; Treatment Failure | 1999 |
7 other study(ies) available for edatrexate and levoleucovorin
| Article | Year |
|---|---|
Alleviation by leucovorin of the dose-limiting toxicity of edatrexate: potential for improved therapeutic efficacy.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Female; Folic Acid Antagonists; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Stomatitis | 1991 |
Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
Topics: Aminopterin; Animals; Drug Resistance; Folic Acid Antagonists; Leucovorin; Methotrexate; Methylcholanthrene; Polyglutamic Acid; Rats; Sarcoma, Experimental; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1991 |
Intracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection.
Topics: Aminopterin; Animals; Cisplatin; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Injections, Intraperitoneal; Injections, Subcutaneous; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred C3H; Ovarian Neoplasms | 1989 |
Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Division; Folic Acid; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured | 1994 |
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Topics: Aminopterin; Animals; Carrier Proteins; Cell Division; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Haplorhini; Humans; Kidney; Leucovorin; Methotrexate; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1995 |
Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein.
Topics: Aminopterin; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Kinetics; Leucovorin; Methotrexate; Quinazolines; Receptors, Cell Surface; Structure-Activity Relationship | 1993 |
Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
Topics: Adenocarcinoma; Aminopterin; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibrosarcoma; Leucovorin; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Salvage Therapy | 1993 |