edatrexate has been researched along with aminopterin in 106 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 13 (12.26) | 18.7374 |
| 1990's | 85 (80.19) | 18.2507 |
| 2000's | 8 (7.55) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Abraham, A; Galivan, J; Gaumont, Y; Kisliuk, RL; McGuire, JJ; Nair, MG; Nimec, Z | 1 |
| Bader, H; Keyomarsi, K; Matherly, LH; Rosowsky, A; Wright, JE | 1 |
| Bader, H; Forsch, RA; Rosowsky, A; Vaidya, CM; Wright, JE | 1 |
| Allen, R; Harper, PG; Lamond, P; Rudd, RM; Souhami, RL; Spiro, SG | 1 |
| Bertino, JR; Brennan, MF; Li, WW; Lin, JT; Tong, WP; Trippett, TM | 1 |
| Yoshimura, A | 1 |
| Fleming, GF; Schilsky, RL | 1 |
| Casper, ES; Johnson, B; Kelsen, DP; Schwartz, GK | 1 |
| de Graeff, A; Dullemond-Westland, A; Schornagel, JH; ten Bokkel Huinink, WW; van Deijk, WA; van der Vegt, S; Verweij, J | 1 |
| Johnson, CA; Otter, GM; Piper, JR; Sirotnak, FM | 1 |
| Armand, JP; Cappelaere, P; Clavel, M; Cognetti, F; de Mulder, PH; Kirkpatrick, A; Schornagel, JH; Vermorken, JB; Verweij, J; Wildiers, J | 1 |
| Green, MD; Sherman, P; Zalcberg, J | 1 |
| Hordijk, GJ; Jansen, G; Kathmann, GA; Schornagel, JH; van der Laan, BF; Westerhof, GR | 1 |
| Hong, WK; Lee, JS; Murphy, WK; Pang, A; Shirinian, MH | 1 |
| Dimery, IW; Fossella, FV; Glisson, BS; Hong, WK; Lee, JS; Libshitz, HI; Lippman, SM; Murphy, WK; Pang, AC; Shin, DM | 1 |
| Bertino, JR; Li, WW; Lin, JT; Schweitzer, BI | 1 |
| Bertino, JR; Chang, YM; Li, WW; Lin, JT; Schweitzer, B | 1 |
| Braakhuis, BJ; Brown, DH; Snow, GB; Van Dongen, GA | 1 |
| Hong, WK; Jeffries, D; Lee, JS; Libshitz, HI; Murphy, WK | 1 |
| Otter, GM; Rumberger, BG; Schmid, FA; Sirotnak, FM | 1 |
| Beijnen, JH; Bruning, PF; Nooyen, WJ; van der Woude, HR; van Tellingen, O | 1 |
| Clavel, M; Cognetti, F; de Mulder, P; Henzen-Logmans, S; Schornagel, J; Vermorken, J; Verweij, J | 1 |
| Israel, K; Kemeny, N; O'Hehir, M | 1 |
| Fanucchi, MP; Farag, F; Kinahan, JJ; Samuels, LL; Sirotnak, FM; Vidal, PM; Young, CW | 1 |
| Chou, TC; DeGraw, JI; Fanucchi, MP; Farag, F; Hancock, C; Kinahan, JJ; Niedzwiecki, D; Samuels, LL; Sternberg, SS; Vidal, PM | 1 |
| Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG; Nanavati, NT | 1 |
| DeGraw, JI; Samuels, LL; Schmid, FA; Sirotnak, FM | 1 |
| Freisheim, JH; Gaumont, Y; Kisliuk, RL; Kumar, P; Nair, MG | 1 |
| DeGraw, JI; Schmid, FA; Sirotnak, FM | 1 |
| Burke, MT; Gralla, RJ; Heelan, RT; Kris, MG; Marks, LD; Shum, KY | 1 |
| Fanucchi, MP; Farag, F; Gralla, RJ; Kinahan, JJ; Kris, MG; Marks, LD; O'Connell, JP; Wertheim, MS; Williams, L; Young, CW | 1 |
| Christie, PH; DeGraw, JI; Gaumont, Y; Kisliuk, RL; Schmid, FA; Sirotnak, FM; Tagawa, H | 1 |
| Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| DeGraw, JI; Goutas, LJ; Moccio, DM; Samuels, LL; Sirotnak, FM | 1 |
| DeGraw, JI; Goutas, LJ; Moccio, DM; Schmid, FA; Sirotnak, FM | 1 |
| Braakhuis, BJ; Jansen, G; Kegel, A; Noordhuis, P; Peters, GJ | 1 |
| Jansen, G; Jolivet, J; Peters, GJ; Pinard, MF; Schornagel, JH | 1 |
| Begg, C; Cohen, L; Kelly, WK; Liebertz, C; Scher, HI; Schultz, PK | 1 |
| Bready, B; Fueger, RH; Giannone, L; Levin, B; Lin, YG; Maldonado, A; Moore, DF; Pazdur, R; Winn, RJ | 1 |
| Gralla, RJ | 1 |
| Campbell, DL; Perez, EA; Ryu, JK | 1 |
| Armand, JP; Cappelaere, P; Clavel, M; Cognetti, F; de Graeff, A; de Mulder, PH; Schornagel, JH; Vermorken, JB; Verweij, J; Wildiers, J | 1 |
| Jansen, G; Peters, GJ; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Cheson, B; Christian, M; Feigal, EG; Friedman, MA; Grever, M | 1 |
| Grant, SC; Kris, MG | 1 |
| Klastersky, J | 1 |
| Benner, SE; Dimery, IW; Esparaz, B; Frenning, D; Guillory-Perez, C; Hong, WK; Huber, MH; Lippman, SM; Shirinian, M | 1 |
| Benedetti, J; Ensley, J; Grunberg, SM; Kuebler, JP; Marshall, ME; Muirhead, MJ; Richert-Boe, KE; Schuller, DE | 1 |
| Grant, SC; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR | 1 |
| Bodurtha, A; Boos, G; Bramwell, V; Eisenhauer, E; Knowling, M; Quirt, I | 1 |
| Bookman, M; Broun, ER; Iseminger, KA | 1 |
| Chou, TC; Fletcher, TS; Hack, FM; Perez, EA | 1 |
| Ramos-Remus, C; Russell, AS; Skeith, KJ | 1 |
| Tsukagoshi, S | 2 |
| Bergoltz, VV; Bolanowska, WE; Haile, WH; Haneda, T; Heitzman, KJ; Kotake, Y; McGuire, JJ; Nomura, H; Russell, CA | 1 |
| Abbruzzese, JL; Ajani, JA; Belt, RJ; Bready, B; Dubovsky, DW; Mangold, C; Moore, DF; Pazdur, R; Wade, JL; Winn, RJ | 1 |
| Chou, TC; Hack, FM; Perez, EA; Webber, LM | 1 |
| Otter, GM; Sirotnak, FM | 1 |
| Braakhuis, BJ; Jansen, G; Peters, GJ | 1 |
| Jansen, G; Pinedo, HM; Rijnboutt, S; Schornagel, JH; Westerhof, GR | 1 |
| Costa Garcia, A; Malone, MA; Smyth, MR; Tunon Blanco, P | 1 |
| Braich, TA; Jett, JR; Kardinal, CG; Mailliard, JA; Michalak, JC; Morton, RF; Su, JQ; Veeder, MH; Wiesenfeld, M | 1 |
| Buckman, RA; Eisenhauer, EA; Lopez, P; Muldal, A; Norris, BD; Pritchard, KI; Trudeau, ME; Vandenberg, TA; Verma, SS | 1 |
| Cheson, BD; Phillips, PH; Sorenson, JM | 1 |
| Allen, R; Harland, SJ; Hartley, JM; Lamond, P; Nicholson, PW; Souhami, RL | 1 |
| Bertino, JR; Brennan, MF; Casper, ES; Christman, KL; Johnson, B; Schwartz, GK | 1 |
| Grant, SC; Kris, MG; Sirotnak, FM; Young, CW | 1 |
| Chou, TC; Sirotnak, FM; Tan, QH | 1 |
| Otter, GM; Schmid, FA; Sirotnak, FM | 1 |
| Bodurtha, AJ; Davidson, J; Eisenhauer, EA; Iscoe, NA; Quirt, IC; Verma, S; Young, VJ | 1 |
| Chou, TC; Otter, GM; Sirotnak, FM | 1 |
| Perez, EA | 1 |
| Edelman, MJ; Gandara, DR | 1 |
| Hortobagyi, GN; Ibrahim, N | 1 |
| Jansen, G; Jolivet, J; Kathmann, I; Molthoff, C; Pinard, MF; Ratnam, M; Schornagel, JH; Westerhof, R | 1 |
| Anderson, M; Chu, E; Dearing, MP; Englee-Miller, MJ; Gazdar, AF; Kramer, BS; Kratzke, RA; Mulshine, JL; Venzon, D; Weinstein, J | 1 |
| Clamon, GH; Dreicer, R; Hohl, RJ; Riggs, CE | 1 |
| Pizzorno, G; Rayl, EA | 1 |
| Holmes, FA | 2 |
| Allegra, CJ; Takimoto, CH | 1 |
| Broun, ER; Iseminger, KA; Lentz, SL; Lincoln, S; Malfetano, JH; Mannel, R; Rose, PG | 1 |
| Egan, MG; Roy, K; Sirlin, S; Sirotnak, FM | 1 |
| Dreicer, R; Kirkwood, JM; Kuzel, T; Loehrer, PJ; O'Dwyer, PJ; Propert, KJ | 1 |
| Armand, JP | 1 |
| Chatterjee, DJ; Koda, RT; Li, WY | 1 |
| Blakley, RL; Lewis, WS; Mareya, SM; Patel, M; Sleep, SE; Sorrentino, BP; Spencer, HT | 1 |
| Takimoto, CH | 1 |
| Crowley, JJ; Edelman, MJ; Gandara, DR; Lau, DH; Livingston, RB | 1 |
| Edelman, MJ; Gandara, DR; Lau, D; Lauder, I; Meyers, F; Perez, EA; Turrell, C; Uhrich, M | 1 |
| Colwell, WT; DeGraw, JI; Piper, JR; Sirotnak, FM | 1 |
| Bertino, JR; Densmore, CL; Fleisher, M; Grant, SC; Heelan, RT; Kris, MG; Krol, G; Miller, VA; Pfister, DG; Pisters, KM; Rigas, JR; Sirotnak, FM; Tong, W; Tyson, LB | 1 |
| Baselga, J; D'Andrea, G; Fennelly, D; Gilewski, T; Hudis, C; Moynahan, ME; Norton, L; Raptis, G; Seidman, AD; Sklarin, N; Surbone, A; Templeton, MA; Theodoulou, M; Yao, TJ | 1 |
| Sirotnak, FM | 1 |
| Aghi, M; Breakefield, XO; Kramm, CM | 1 |
| Chou, TC; Fennelly, DW; Grant, SC; Heelan, RT; Kris, MG; Miller, VA; Pisters, KM; Rigas, JR; Sirotnak, FM | 1 |
| Belani, CP; Green, MR; Herndon, JE; Kindler, HL; Suzuki, Y; Vogelzang, NJ | 1 |
| Strømhaug, A; Warren, DJ | 1 |
| Barrueco, JR; Dawson, MI; Hobbs, PD; O'Krongly, D; Sirotnak, FM | 1 |
| Kris, MG; Miller, VA; Scher, HI; Sirotnak, FM; Zakowski, MF | 1 |
| Chronowski, G; Heelan, RT; Kris, MG; Laurie, SA; Pfister, DG; Pisters, KM; Sirotnak, FM; Tong, WP | 1 |
| Khokhar, NZ; Rusch, VW; She, Y; Sirotnak, FM | 1 |
| Colon-Otero, G; Geyer, S; Hillman, SH; Jett, JJ; Krook, JE; Marks, RS; Niedringhaus, RD; Sloan, J; Tschetter, LK; Wiesenfeld, M; Windschitl, HE | 1 |
| Gandara, DR; Kuriakose, P; Perez, EA | 1 |
| Beinart, GA; Booser, D; Broglio, K; Dhingra, K; Frye, D; Gonzalez-Angulo, AM; Gunale, S; Holmes, FA; Hortobagyi, GN; Rosenthal, J; Walters, R; Young, JA | 1 |
17 review(s) available for edatrexate and aminopterin
| Article | Year |
|---|---|
[New analogues of methotrexate].
Topics: Aminopterin; Animals; Antineoplastic Agents; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Methotrexate; Trimetrexate | 1992 |
Antifolates: the next generation.
Topics: Aminopterin; Animals; Antineoplastic Agents; Chemistry, Pharmaceutical; Clinical Trials as Topic; Drug Evaluation; Folic Acid Antagonists; Forecasting; Humans; Neoplasms; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 1992 |
Edatrexate studies in non-small cell lung cancer.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Folic Acid Antagonists; Humans; Lung Neoplasms | 1995 |
New chemotherapeutic agents in non-small-cell lung cancer.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Drug Design; Humans; Interferons; Irinotecan; Lung Neoplasms; Paclitaxel; Topotecan; Vinblastine; Vinorelbine | 1993 |
New antineoplastic agents in lung cancer 1988-1993.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Clinical Trials as Topic; Humans; Irinotecan; Lung Neoplasms; Nitrosourea Compounds; Organophosphorus Compounds; Paclitaxel; Teniposide; Vinblastine; Vinorelbine | 1995 |
New drug for therapy of non-small cell lung cancer.
Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine | 1994 |
New chemotherapeutic agents for non-small cell lung cancer.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Irinotecan; Lung Neoplasms; Paclitaxel; Quinoxalines; Sulfanilamides; Taxoids; Topotecan; Vinblastine; Vinorelbine | 1995 |
[Recent development of new anticancer drugs in Japan].
Topics: Aminopterin; Antineoplastic Agents; Camptothecin; Cisplatin; Cytarabine; Irinotecan; Methotrexate; Paclitaxel; Tretinoin; Tubulin Modulators; Vinblastine; Vinorelbine | 1993 |
[Development of antimetabolites, II].
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Cytarabine; Deoxycytidine; Humans; Leukemia L1210; Methotrexate; Mice; Trimetrexate | 1993 |
Edatrexate, an antifolate with antitumor activity: a review.
Topics: Aminopterin; Animals; Antineoplastic Agents; Clinical Trials as Topic; Folic Acid Antagonists; Humans | 1993 |
Promising new agents in the treatment of non-small cell lung cancer.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma, Non-Small-Cell Lung; Clinical Trials as Topic; Deoxycytidine; Docetaxel; Gemcitabine; Humans; Lung Neoplasms; Paclitaxel; Taxoids; Vinblastine; Vinorelbine | 1996 |
Antifolates: current developments.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Thymidylate Synthase | 1996 |
Paclitaxel combination therapy in the treatment of metastatic breast cancer: a review.
Topics: Aminopterin; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Synergism; Drugs, Investigational; Female; Fluorouracil; Genetic Therapy; Humans; Leucovorin; Neoplasm Metastasis; Oncogenes; Paclitaxel; Radiotherapy, Adjuvant | 1996 |
New antifolates in clinical development.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Antineoplastic Agents; Drugs, Investigational; Folic Acid Antagonists; Humans; Neoplasms; Pyrimidines; Quinazolines; Thiophenes; Trimetrexate | 1995 |
Paclitaxel combination therapy in the treatment of metastatic breast cancer.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Doxorubicin; Drug Interactions; Drug Synergism; Epirubicin; Fluorouracil; Humans; Ifosfamide; Neoplasm Metastasis; Paclitaxel | 1996 |
New anticancer drugs in Europe.
Topics: Aminopterin; Anthraquinones; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Aziridines; Bridged-Ring Compounds; Bryostatins; Camptothecin; Dacarbazine; Deoxycytidine; Distamycins; Doxorubicin; Europe; Gemcitabine; Humans; Indolequinones; Indoles; Irinotecan; Lactones; Macrolides; Nitrogen Mustard Compounds; Nitrosourea Compounds; Pyrazoles; Quinazolines; Taxoids; Temozolomide; Thiophenes; Vinca Alkaloids | 1997 |
Antifolates in clinical development.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Clinical Trials as Topic; Drug Design; Enzyme Inhibitors; Folic Acid Antagonists; Glutamates; Guanine; Humans; Indoles; Isoindoles; Pemetrexed; Pyrimidines; Quinazolines; Tetrahydrofolates; Thiophenes; Thymidylate Synthase | 1997 |
33 trial(s) available for edatrexate and aminopterin
| Article | Year |
|---|---|
Phase II study of Edatrexate in stage III and IV non-small-cell lung cancer.
Topics: Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Neoplasm Staging | 1992 |
Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aminopterin; Antineoplastic Agents; Bile Duct Neoplasms; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pancreatic Neoplasms | 1992 |
Phase II study of edatrexate in chemotherapy-naive patients with metastatic breast cancer.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Middle Aged; Neoplasm Metastasis | 1992 |
A phase II trial of 10-ethyl-10-deaza-aminopterin, a novel antifolate, in patients with advanced and/or recurrent squamous cell carcinoma of the head and neck. The EORTC Head and Neck Cancer Cooperative Group.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Female; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Leukopenia; Male; Middle Aged; Neoplasm Metastasis; Neoplasm Recurrence, Local; Thrombocytopenia | 1992 |
Phase II study of 10-EdAM in patients with squamous cell carcinoma of the head and neck, previously untreated with chemotherapy.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Evaluation; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged | 1992 |
Edatrexate improves the antitumor effects of cyclophosphamide and cisplatin against non-small cell lung cancer.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Synergism; Female; Humans; Lung Neoplasms; Male; Middle Aged | 1991 |
Toxic dermatitis induced by 10-ethyl-10-deaza-aminopterin (10-EdAM), a novel antifolate.
Topics: Aged; Aminopterin; Carcinoma, Squamous Cell; Dermatitis, Contact; Drug Evaluation; Female; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Male; Middle Aged; Skin | 1990 |
Phase I trial and clinical pharmacological evaluation of 10-ethyl-10-deazaaminopterin in adult patients with advanced cancer.
Topics: Adult; Aminopterin; Antimetabolites, Antineoplastic; Drug Evaluation; Half-Life; Humans; Neoplasms; Skin Neoplasms | 1988 |
Post-therapy change in prostate-specific antigen levels as a clinical trial endpoint in hormone-refractory prostatic cancer: a trial with 10-ethyl-deaza-aminopterin.
Topics: Aged; Aminopterin; Antineoplastic Agents; Follow-Up Studies; Humans; Male; Middle Aged; Prostate-Specific Antigen; Prostatic Neoplasms; Treatment Outcome | 1994 |
Phase II trial of edatrexate in patients with advanced hepatocellular carcinoma.
Topics: Adult; Aged; Agranulocytosis; alpha-Fetoproteins; Aminopterin; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Folic Acid Antagonists; Humans; Liver Neoplasms; Male; Middle Aged; Remission Induction; Thrombocytopenia | 1994 |
Randomized phase III trial of edatrexate versus methotrexate in patients with metastatic and/or recurrent squamous cell carcinoma of the head and neck: a European Organization for Research and Treatment of Cancer Head and Neck Cancer Cooperative Group stu
Topics: Agranulocytosis; Aminopterin; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Administration Schedule; Female; Head and Neck Neoplasms; Humans; Injections, Intravenous; Lung; Male; Methotrexate; Respiratory Distress Syndrome; Thrombocytopenia | 1995 |
Phase II study of carboplatin and edatrexate (10-EdAM) with leucovorin rescue for patients with recurrent squamous cell carcinoma of the head and neck.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Leucovorin; Male; Middle Aged; Neoplasm Recurrence, Local | 1994 |
Phase II study of edatrexate in advanced head and neck cancer. A Southwest Oncology Group study.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Carcinoma, Squamous Cell; Female; Head and Neck Neoplasms; Humans; Male; Middle Aged; Neoplasm Recurrence, Local | 1994 |
Phase II trial of 10-EDAM in advanced soft tissue sarcoma. A study of the Canadian Sarcoma Group and the National Cancer Institute of Canada Clinical Trials Group.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Canada; Female; Folic Acid Antagonists; Humans; Male; Middle Aged; Mouth Mucosa; Neutropenia; Sarcoma; Soft Tissue Neoplasms; Stomatitis | 1994 |
A phase II trial of edatrexate in previously treated ovarian cancer. A Gynecologic Oncology Group study.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Female; Humans; Infusions, Intravenous; Middle Aged; Neoplasm Recurrence, Local; Ovarian Neoplasms; Treatment Outcome | 1995 |
Phase II trial of edatrexate in patients with advanced pancreatic adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Female; Humans; Liver Neoplasms; Male; Middle Aged; Pancreatic Neoplasms; Survival Rate | 1994 |
Phase II trial of edatrexate in small cell lung cancer.
Topics: Aged; Aminopterin; Carcinoma, Small Cell; Female; Humans; Lung Neoplasms; Male; Middle Aged; Survival Analysis | 1994 |
Phase II study of weekly edatrexate as first-line chemotherapy for metastatic breast cancer: a National Cancer Institute of Canada Clinical Trials Group study.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Breast Neoplasms; Drug Administration Schedule; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Middle Aged; Neoplasm Metastasis; Treatment Outcome | 1993 |
Edatrexate in patients with soft tissue sarcoma. Activity in malignant fibrous histiocytoma.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Female; Histiocytoma, Benign Fibrous; Humans; Male; Middle Aged; Neoplasms, Vascular Tissue; Sarcoma; Soft Tissue Neoplasms; Treatment Outcome | 1993 |
A phase II study of weekly edatrexate (10-EDAM) in metastatic melanoma. A National Cancer Institute of Canada Clinical Trials Group study.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Canada; Drug Administration Schedule; Humans; Melanoma; Middle Aged | 1993 |
Phase II trial of edatrexate in patients with metastatic colorectal cancer.
Topics: Aged; Aminopterin; Antineoplastic Agents; Colorectal Neoplasms; Female; Humans; Male; Middle Aged | 1996 |
A phase II trial of edatrexate in previously treated squamous cell cervical cancer: a Gynecologic Oncology Group study.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Carcinoma, Squamous Cell; Fanconi Syndrome; Female; Folic Acid Antagonists; Humans; Middle Aged; Neoplasm Recurrence, Local; Uterine Cervical Neoplasms | 1997 |
A phase II trial of edatrexate in patients with advanced renal cell carcinoma. An Eastern Cooperative Oncology Group study.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Renal Cell; Female; Gastrointestinal Diseases; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Prognosis; Remission Induction; Stomatitis; Survival Analysis | 1997 |
Phase II trial of edatrexate plus carboplatin in metastatic non-small-cell lung cancer: a Southwest Oncology Group study.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Non-Small-Cell Lung; Drug Administration Schedule; Female; Humans; Lung Neoplasms; Male; Middle Aged; Mouth Mucosa; Neutropenia; Survival Analysis; Treatment Outcome | 1997 |
Phase I trial of edatrexate plus carboplatin in advanced solid tumors: amelioration of dose-limiting mucositis by ice chip cryotherapy.
Topics: Adult; Aged; Aminopterin; Anemia; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cryotherapy; Exanthema; Female; Humans; Leukopenia; Male; Middle Aged; Mucous Membrane; Neoplasms; Vomiting | 1998 |
High-dose edatrexate with oral leucovorin rescue: a phase I and clinical pharmacological study in adults with advanced cancer.
Topics: Administration, Oral; Adult; Aged; Aminopterin; Antineoplastic Agents; Drug Interactions; Drug Monitoring; Female; Humans; Leucovorin; Male; Middle Aged; Neoplasms | 1996 |
Phase I study of escalating doses of edatrexate in combination with paclitaxel in patients with metastatic breast cancer.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Humans; Middle Aged; Neoplasm Metastasis; Paclitaxel; Treatment Outcome | 1999 |
Phase I study of the sequential administration of edatrexate and paclitaxel in patients with advanced solid tumors.
Topics: Adult; Aged; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Female; Humans; Male; Middle Aged; Neoplasms; Paclitaxel | 1999 |
Edatrexate (10-ethyl-deaza-aminopterin) (NSC #626715) with or without leucovorin rescue for malignant mesothelioma. Sequential phase II trials by the cancer and leukemia group B.
Topics: Aminopterin; Antineoplastic Agents; Dose-Response Relationship, Drug; Female; Humans; Leucovorin; Leukemia; Male; Mesothelioma; Middle Aged; Pleural Neoplasms; Survival Rate; Treatment Failure | 1999 |
Phase I and pharmacological study of two schedules of the antifolate edatrexate in combination with cisplatin.
Topics: Adult; Aged; Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Carcinoma, Non-Small-Cell Lung; Cisplatin; Dose-Response Relationship, Drug; Female; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Lung Neoplasms; Male; Middle Aged; Time Factors; Treatment Outcome | 2001 |
A phase II trial of edatrexate, vinblastine, adriamycin, cisplastin, and filgrastim (EVAC/G-CSF) in patients with non-small-cell carcinoma of the lungs: a North Central Cancer Treatment Group Trial.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Doxorubicin; Female; Filgrastim; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Male; Middle Aged; Recombinant Proteins; Remission Induction; Sickness Impact Profile; Survival Analysis; Vinblastine | 2001 |
Phase I trial of edatrexate in advanced breast and other cancers.
Topics: Adult; Aged; Aged, 80 and over; Aminopterin; Antineoplastic Agents; Breast Neoplasms; Female; Humans; Infusions, Intravenous; Karnofsky Performance Status; Lung Neoplasms; Maximum Tolerated Dose; Melanoma; Menopause; Middle Aged; Receptors, Estrogen; Receptors, Progesterone; Treatment Outcome | 2002 |
Phase II trial of 10-EDAM in the treatment of metastatic breast cancer.
Topics: Adult; Aged; Agranulocytosis; Alopecia; Aminopterin; Anemia; Antineoplastic Agents; Breast Neoplasms; Disease Progression; Female; Humans; Leukopenia; Middle Aged; Nausea; Survival Analysis; Time Factors; Treatment Outcome | 2007 |
56 other study(ies) available for edatrexate and aminopterin
| Article | Year |
|---|---|
Folate analogues. 34. Synthesis and antitumor activity of non-polyglutamylatable inhibitors of dihydrofolate reductase.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Division; Cell Line; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Indicators and Reagents; Methotrexate; Molecular Structure; Recombinant Proteins; Structure-Activity Relationship | 1991 |
Synthesis and biological activity of N omega-hemiphthaloyl-alpha,omega- diaminoalkanoic acid analogues of aminopterin and 3',5-dichloroaminopterin.
Topics: Aminopterin; Animals; Antineoplastic Agents; Cell Division; Folic Acid Antagonists; Humans; Methotrexate; Mice; Ornithine; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 1994 |
Analogues of the potent nonpolyglutamatable antifolate N(alpha)-(4-amino-4-deoxypteroyl)-N(delta)-hemiphthaloyl-L-ornithine (PT523) with modifications in the side chain, p-aminobenzoyl moiety, or 9,10-bridge: synthesis and in vitro antitumor activity.
Topics: Antineoplastic Agents; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Humans; Inhibitory Concentration 50; Ornithine; Pterins; Structure-Activity Relationship; Tumor Cells, Cultured | 2000 |
Mechanisms of natural resistance to antifolates in human soft tissue sarcomas.
Topics: Aminopterin; Chromatography, High Pressure Liquid; Drug Resistance; Folic Acid Antagonists; Humans; Methotrexate; Peptide Synthases; Polyglutamic Acid; Sarcoma; Soft Tissue Neoplasms; Tetrahydrofolate Dehydrogenase; Thymidylate Synthase; Trimetrexate; Tumor Stem Cell Assay | 1992 |
Synthesis and antifolate evaluation of 10-ethyl-5-methyl-5,10- dideazaaminopterin and an alternative synthesis of 10-ethyl-10- deazaaminopterin (edatrexate).
Topics: Aminopterin; Animals; Antineoplastic Agents; Folic Acid Antagonists; Leukemia L1210; Tumor Cells, Cultured | 1992 |
In vitro activity of novel antifolates against human squamous carcinoma cell lines of the head and neck with inherent resistance to methotrexate.
Topics: Aminopterin; Biological Transport; Carcinoma, Squamous Cell; Cell Division; Cell Line; Cell Membrane; Drug Resistance; Drug Screening Assays, Antitumor; Folic Acid; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Tetrahydrofolate Dehydrogenase; Tetrahydrofolates; Tumor Cells, Cultured | 1992 |
Alleviation by leucovorin of the dose-limiting toxicity of edatrexate: potential for improved therapeutic efficacy.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Cisplatin; Cyclophosphamide; Dose-Response Relationship, Drug; Drug Evaluation; Drug Tolerance; Female; Folic Acid Antagonists; Humans; Leucovorin; Lung Neoplasms; Male; Middle Aged; Stomatitis | 1991 |
Mechanisms of sensitivity and natural resistance to antifolates in a methylcholanthrene-induced rat sarcoma.
Topics: Aminopterin; Animals; Drug Resistance; Folic Acid Antagonists; Leucovorin; Methotrexate; Methylcholanthrene; Polyglutamic Acid; Rats; Sarcoma, Experimental; Tetrahydrofolate Dehydrogenase; Trimetrexate; Tumor Cells, Cultured | 1991 |
Prediction of antifolate efficacy in a rat sarcoma model.
Topics: Aminopterin; Animals; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Male; Methotrexate; Methylcholanthrene; Quinazolines; Rats; Sarcoma, Experimental; Thymidylate Synthase; Trimetrexate | 1991 |
Comparative study of the sensitivity of head and neck cell lines to methotrexate (MTX) and the analog 10-ethyl, 10-deazaaminopterin (10-EdAM).
Topics: Aminopterin; Carcinoma, Squamous Cell; Cell Line; Folic Acid Antagonists; Head and Neck Neoplasms; In Vitro Techniques; Methotrexate; Tumor Cells, Cultured | 1990 |
Phase II study of 10-ethyl-10-deaza-aminopterin (10-EdAM; CGP 30 694) for stage IIIB or IV non-small cell lung cancer.
Topics: Adult; Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging; Pleural Effusion | 1990 |
Preferential selection during therapy in vivo by edatrexate compared to methotrexate of resistant L1210 cell variants with decreased folylpolyglutamate synthetase activity.
Topics: Aminopterin; Animals; Drug Resistance; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Neoplasm Transplantation; Peptide Synthases; Phenotype | 1990 |
High-performance liquid chromatographic method for the analysis of 10-ethyl-10-deaza-aminopterin and metabolites in plasma.
Topics: Aminopterin; Chromatography, High Pressure Liquid; Folic Acid Antagonists; Humans | 1990 |
Phase II trial of 10-Edam in patients with advanced colorectal carcinoma.
Topics: Abdominal Pain; Adult; Aged; Aminopterin; Carcinoma; Colonic Neoplasms; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Injections, Intravenous; Male; Middle Aged; Rectal Neoplasms; Remission Induction | 1990 |
Fluorometric high-performance liquid chromatographic analysis of 10-deazaaminopterin, 10-ethyl-10-deazaaminopterin, and known metabolites.
Topics: Aminopterin; Animals; Chromatography, High Pressure Liquid; Humans; Leukemia L1210; Mice; Mice, Nude; Neoplasms; Polyglutamic Acid; Spectrometry, Fluorescence | 1985 |
Toxicity, elimination, and metabolism of 10-ethyl-10-deazaaminopterin in rats and dogs.
Topics: Aminopterin; Animals; Dogs; Mathematics; Polyglutamic Acid; Rats; Tissue Distribution | 1987 |
Synthesis and biological evaluation of poly-gamma-glutamyl metabolites of 10-deazaaminopterin and 10-ethyl-10-deazaaminopterin.
Topics: Aminopterin; Animals; Anti-Bacterial Agents; Female; Folic Acid Antagonists; gamma-Glutamyl Hydrolase; Humans; Lacticaseibacillus casei; Methotrexate; Mice; Mice, Inbred Strains; Microbial Sensitivity Tests; Peptides; Polyglutamic Acid; Streptococcus; Structure-Activity Relationship; Substrate Specificity | 1988 |
10-Ethyl-10-deaza-aminopterin: structural design and biochemical, pharmacologic, and antitumor properties.
Topics: Aminopterin; Animals; Biological Transport; Biotransformation; Cell Division; Cell Membrane; Cell Survival; Folic Acid Antagonists; Intestine, Small; Leukemia L1210; Mice; Neoplasms, Experimental; Polyglutamic Acid; Structure-Activity Relationship | 1987 |
Inhibition of human dihydrofolate reductase by antifolyl polyglutamates.
Topics: Aminopterin; Folic Acid Antagonists; Humans; Methotrexate; Peptides; Polyglutamic Acid | 1989 |
Intracavitary therapy of murine ovarian cancer with cis-diamminedichloroplatinum(II) and 10-ethyl-10-deazaaminopterin incorporating systemic leucovorin protection.
Topics: Aminopterin; Animals; Cisplatin; Drug Evaluation, Preclinical; Female; Folic Acid Antagonists; Injections, Intraperitoneal; Injections, Subcutaneous; Leucovorin; Male; Methotrexate; Mice; Mice, Inbred C3H; Ovarian Neoplasms | 1989 |
Phase II study of 10-ethyl-10-deaza-aminopterin in patients with stage III and IV non-small-cell lung cancer.
Topics: Aged; Aminopterin; Carcinoma, Non-Small-Cell Lung; Drug Evaluation; Female; Folic Acid Antagonists; Humans; Lung Neoplasms; Male; Middle Aged; Neoplasm Staging | 1988 |
Synthesis and biological activity of resolved C-10 diastereomers of 10-methyl- and 10-ethyl-10-deazaminopterin.
Topics: Aminopterin; Animals; Folic Acid Antagonists; Leukemia L1210; Methotrexate; Mice; Stereoisomerism; Structure-Activity Relationship | 1986 |
Similar differential for total polyglutamylation and cytotoxicity among various folate analogues in human and murine tumor cells in vitro.
Topics: Aminopterin; Animals; Cells, Cultured; Folic Acid; Humans; Kinetics; Leukemia L1210; Methotrexate; Mice; Neoplasms; Pteroylpolyglutamic Acids; Tumor Stem Cell Assay | 1985 |
New folate analogs of the 10-deaza-aminopterin series. Basis for structural design and biochemical and pharmacologic properties.
Topics: Aminopterin; Animals; Cells, Cultured; Epithelium; Female; Folic Acid Antagonists; Intestine, Small; Kinetics; Mice; Structure-Activity Relationship | 1984 |
New folate analogs of the 10-deaza-aminopterin series. Further evidence for markedly increased antitumor efficacy compared with methotrexate in ascitic and solid murine tumor models.
Topics: Aminopterin; Animals; Drug Evaluation, Preclinical; Female; Methotrexate; Mice; Neoplasms, Experimental; Structure-Activity Relationship | 1984 |
Importance of pharmacodynamics in the in vitro antiproliferative activity of the antifolates methotrexate and 10-ethyl-10-deazaaminopterin against human head and neck squamous cell carcinoma.
Topics: Aminopterin; Carcinoma, Squamous Cell; Cell Division; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured | 1993 |
Leucovorin rescue of human cancer and bone marrow cells following edatrexate or methotrexate.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Cell Division; Folic Acid; Humans; Leucovorin; Methotrexate; Polyglutamic Acid; Tumor Cells, Cultured | 1994 |
Radiation recall dermatitis induced by edatrexate in a patient with breast cancer.
Topics: Adult; Aminopterin; Antineoplastic Agents; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Drug Eruptions; Female; Humans; Radiodermatitis | 1995 |
Functional activity of the reduced folate carrier in KB, MA104, and IGROV-I cells expressing folate-binding protein.
Topics: Aminopterin; Animals; Carrier Proteins; Cell Division; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Glutamates; Haplorhini; Humans; Kidney; Leucovorin; Methotrexate; Nasopharyngeal Neoplasms; Ovarian Neoplasms; Quinazolines; Receptors, Cell Surface; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1995 |
Modulation of intrinsic in vitro resistance to carboplatin by edatrexate in the A549 human nonsmall cell lung cancer cell line.
Topics: Aminopterin; Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Drug Interactions; Drug Resistance; Humans; Kinetics; Lung Neoplasms; Time Factors; Tumor Cells, Cultured | 1994 |
Comparative efficacy and toxicity of 10-ethyl-10-deazaaminopterin and methotrexate in a mycobacterial rat arthritis model.
Topics: Aminopterin; Animals; Arthritis, Experimental; Drug Evaluation, Preclinical; Female; Intestinal Diseases; Methotrexate; Nontuberculous Mycobacteria; Peritonitis; Rats; Rats, Inbred Lew; Stomatitis | 1994 |
Novel 6,5-fused ring heterocyclic antifolates: biochemical and biological characterization.
Topics: Aminopterin; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Glutamate Synthase; Humans; Leukemia-Lymphoma, Adult T-Cell; Methotrexate; Thymidylate Synthase; Tumor Cells, Cultured | 1994 |
Schedule-dependent synergism of edatrexate and cisplatin in combination in the A549 lung-cancer cell line as assessed by median-effect analysis.
Topics: Adenocarcinoma; Aminopterin; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Humans; Lung Neoplasms; Tumor Cells, Cultured | 1993 |
Effective combination therapy of metastatic murine solid tumors with edatrexate and the vinca alkaloids, vinblastine, navelbine and vindesine.
Topics: Aminopterin; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasms, Experimental; Tumor Cells, Cultured; Vinblastine; Vindesine; Vinorelbine | 1994 |
Variable pharmacodynamics of antifolates in squamous cell carcinoma of the head and neck.
Topics: Aminopterin; Carcinoma, Squamous Cell; Cell Division; Cell Line; Drug Resistance; Drug Screening Assays, Antitumor; Folic Acid Antagonists; Head and Neck Neoplasms; Humans; Methotrexate; Tumor Cells, Cultured | 1993 |
Identification of a reduced folate/methotrexate carrier in human KB-cells expressing high levels of membrane associated folate binding protein.
Topics: Aminopterin; Biological Transport; Carrier Proteins; Cell Division; Cell Membrane; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; KB Cells; Kinetics; Leucovorin; Methotrexate; Quinazolines; Receptors, Cell Surface; Structure-Activity Relationship | 1993 |
Phase-selective AC adsorptive stripping voltammetric assay for aminopterin and 10-Edam in human serum.
Topics: Adsorption; Aminopterin; Chemistry Techniques, Analytical; Humans; Mercury | 1993 |
Clinical trials referral resource. Clinical trials using edatrexate.
Topics: Aminopterin; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Clinical Trials as Topic; Female; Humans; Male; Neoplasms | 1993 |
Pharmacokinetics of 10-ethyl-10-deaza-aminopterin, edatrexate, given weekly for non-small-cell lung cancer.
Topics: Aminopterin; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Chromatography, High Pressure Liquid; Creatinine; Half-Life; Humans; Lung Neoplasms; Metabolic Clearance Rate | 1993 |
Quantitation of the synergistic interaction of edatrexate and cisplatin in vitro.
Topics: Aminopterin; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cell Line; Cisplatin; Computer Simulation; Dose-Response Relationship, Drug; Drug Synergism; Humans; Methotrexate; Tumor Cells, Cultured | 1993 |
Markedly improved efficacy of edatrexate compared to methotrexate in a high-dose regimen with leucovorin rescue against metastatic murine solid tumors.
Topics: Adenocarcinoma; Aminopterin; Animals; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Fibrosarcoma; Leucovorin; Lung Neoplasms; Mammary Neoplasms, Experimental; Melanoma, Experimental; Methotrexate; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Transplantation; Neoplasms, Experimental; Salvage Therapy | 1993 |
Schedule-dependent synergism of taxol or taxotere with edatrexate against human breast cancer cells in vitro.
Topics: Adenocarcinoma; Aminopterin; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Drug Synergism; Humans; Paclitaxel; Prospective Studies; Taxoids; Tumor Cells, Cultured | 1996 |
Schedule-dependent edatrexate toxicity.
Topics: Aminopterin; Antineoplastic Agents; Drug Administration Schedule; Head and Neck Neoplasms; Humans; Methotrexate; Mouth Mucosa; Palliative Care; Stomatitis | 1996 |
Paclitaxel-containing combination chemotherapy for metastatic breast cancer.
Topics: Aminopterin; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Cyclophosphamide; Drug Administration Schedule; Female; Humans; Mitoxantrone; Paclitaxel; Vinblastine; Vinorelbine | 1996 |
Functional aspects of membrane folate receptors in human breast cancer cells with transport-related resistance to methotrexate.
Topics: Aminopterin; Antimetabolites, Antineoplastic; Binding Sites; Breast Neoplasms; Carrier Proteins; Cell Membrane; DNA, Complementary; Female; Folate Receptors, GPI-Anchored; Folic Acid; Folic Acid Antagonists; Humans; Methotrexate; Polymerase Chain Reaction; Quinazolines; Receptors, Cell Surface; RNA, Messenger; Spectrometry, Fluorescence; Structure-Activity Relationship; Tetrahydrofolates; Thiophenes; Tumor Cells, Cultured | 1996 |
Dipyridamole mediated enhanced antiproliferative activity of 10-ethyl-10-deazaaminopterin (10-EDAM) against human lung cancer cell lines.
Topics: Aminopterin; Biological Transport; Cell Division; Depression, Chemical; Dipyridamole; Dose-Response Relationship, Drug; Drug Synergism; Folic Acid Antagonists; Growth Inhibitors; Humans; Lung Neoplasms; Methotrexate; Nucleosides; Thymidine; Tumor Cells, Cultured | 1996 |
Posttranscriptionally mediated decreases in folylpolyglutamate synthetase gene expression in some folate analogue-resistant variants of the L1210 cell. Evidence for an altered cognate mRNA in the variants affecting the rate of de novo synthesis of the enz
Topics: Aminopterin; Animals; Cell Line; Drug Resistance; Folic Acid Antagonists; Gene Expression Regulation, Enzymologic; Mice; Molecular Sequence Data; Peptide Synthases; Transcription, Genetic | 1997 |
Effect of vehicles and penetration enhancers on the in vitro and in vivo percutaneous absorption of methotrexate and edatrexate through hairless mouse skin.
Topics: Administration, Cutaneous; Aminopterin; Animals; Antirheumatic Agents; Azepines; Caprylates; In Vitro Techniques; Methotrexate; Mice; Mice, Hairless; Permeability; Pharmaceutical Vehicles; Skin Absorption; Solubility | 1997 |
Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants.
Topics: Aminopterin; Animals; Cell Survival; Drug Resistance, Neoplasm; Folic Acid Antagonists; Gene Expression; Genetic Variation; Growth Inhibitors; Humans; Kinetics; Methotrexate; Pyrimidines; Rabbits; Tetrahydrofolate Dehydrogenase; Thymidine; Transfection; Trimetrexate | 1997 |
A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in mice.
Topics: Aminopterin; Animals; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Enzyme Inhibitors; Folic Acid Antagonists; Humans; Lung Neoplasms; Methotrexate; Mice; Mice, Nude; Structure-Activity Relationship; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1998 |
Enhancing cytotoxic sensitivity of tumor cells to antifolates: another opportunity for gene therapy?
Topics: Aminopterin; Animals; Antineoplastic Agents; Clone Cells; Folic Acid Antagonists; Genetic Therapy; Humans; Neoplasms; Peptide Synthases; Polyglutamic Acid; Tumor Cells, Cultured | 1999 |
Folylpolyglutamyl synthetase gene transfer and glioma antifolate sensitivity in culture and in vivo.
Topics: Aminopterin; Animals; Antimetabolites, Antineoplastic; Chromatography, Thin Layer; Dogs; Dose-Response Relationship, Drug; Folic Acid Antagonists; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Methotrexate; Neoplasms; Peptide Synthases; Rats; Transduction, Genetic; Transfection; Tumor Cells, Cultured | 1999 |
A comparison of the effects of nine folate analogs on early and late murine hematopoietic progenitor cells in vitro.
Topics: Aminopterin; Animals; Cell Division; Cells, Cultured; Enzyme Inhibitors; Female; Folic Acid; Folic Acid Antagonists; Hematopoietic Stem Cells; Methotrexate; Mice; Mice, Inbred BALB C; Quinazolines; Tetrahydrofolates; Thiophenes; Trimetrexate | 2000 |
Synthesis of the 7-hydroxy metabolites of methotrexate and 10-ethyl-10-deazaaminopterin.
Topics: Aminopterin; Antineoplastic Agents; Folic Acid Antagonists; Methotrexate; Oxidation-Reduction | 1987 |
Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase.
Topics: Aminopterin; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carboplatin; Cell Division; Cisplatin; Docetaxel; Dose-Response Relationship, Drug; ErbB Receptors; Female; Gefitinib; Humans; Immunohistochemistry; Lung Neoplasms; Male; Maximum Tolerated Dose; Mice; Mice, Nude; Neoplasm Transplantation; Paclitaxel; Prostatic Neoplasms; Quinazolines; Reverse Transcriptase Polymerase Chain Reaction; Taxoids; Time Factors; Tumor Cells, Cultured; Vinblastine; Vinorelbine; Vulvar Neoplasms | 2000 |
Experimental therapeutics with a new 10-deazaaminopterin in human mesothelioma: further improving efficacy through structural design, pharmacologic modulation at the level of MRP ATPases, and combined therapy with platinums.
Topics: Adenosine Triphosphatases; Aminopterin; Animals; Anion Transport Proteins; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cell Cycle Proteins; Cell Division; Cisplatin; Drug Design; Fungal Proteins; Gene Expression Regulation, Neoplastic; Humans; Inhibitory Concentration 50; Mesothelioma; Methotrexate; Mice; Mice, Nude; Multidrug Resistance-Associated Proteins; Platinum Compounds; Protein Isoforms; Protein Kinases; RNA, Neoplasm; Schizosaccharomyces pombe Proteins; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |