Compounds > ecteinascidin 743
Page last updated: 2024-09-02

ecteinascidin 743 and trimetrexate

ecteinascidin 743 has been researched along with trimetrexate in 2 studies

Compound Research Comparison

Studies
(ecteinascidin 743)		Trials
(ecteinascidin 743)		Recent Studies (post-2010)
(ecteinascidin 743)		Studies
(trimetrexate)		Trials
(trimetrexate)		Recent Studies (post-2010) (trimetrexate)
6601024044225021

Protein Interaction Comparison

ProteinTaxonomyecteinascidin 743 (IC50)trimetrexate (IC50)
Dihydrofolate reductase Mycobacterium avium0.3012
Dihydrofolate reductaseHomo sapiens (human)0.0207
Dihydrofolate reductaseLacticaseibacillus casei0.1435
Dihydrofolate reductaseSaccharomyces cerevisiae S288C0.042
Dihydrofolate reductaseEscherichia coli K-120.1798
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.026
Dihydrofolate reductasePneumocystis carinii0.0378
Dihydrofolate reductaseCandida albicans0.04
Dipeptidyl peptidase 4Homo sapiens (human)0.01
5-hydroxytryptamine receptor 2BRattus norvegicus (Norway rat)0.008
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii0.5788
Bifunctional dihydrofolate reductase-thymidylate synthaseTrypanosoma cruzi0.0202
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.0794

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (100.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Banerjee, D; Bertino, JR; Li, WW; Scotto, KW; Takahashi, N1

Other Studies

2 other study(ies) available for ecteinascidin 743 and trimetrexate

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Sequence-dependent enhancement of cytotoxicity produced by ecteinascidin 743 (ET-743) with doxorubicin or paclitaxel in soft tissue sarcoma cells.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:10

    Topics: Antineoplastic Agents; Apoptosis; Cell Division; Dioxoles; Doxorubicin; Drug Synergism; Flow Cytometry; Humans; Inhibitory Concentration 50; Isoquinolines; Microscopy, Fluorescence; Paclitaxel; Sarcoma; Tetrahydroisoquinolines; Trabectedin; Trimetrexate; Tumor Cells, Cultured

2001