Page last updated: 2024-09-02

ecteinascidin 743 and nsc 638718

ecteinascidin 743 has been researched along with nsc 638718 in 3 studies

Compound Research Comparison

Studies (ecteinascidin 743)	Trials (ecteinascidin 743)	Recent Studies (post-2010) (ecteinascidin 743)	Studies (nsc 638718)	Trials (nsc 638718)	Recent Studies (post-2010) (nsc 638718)
660	102	404	5	1	0

Research

Studies (3)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Beijnen, JH; Cvitkovic, E; Hillebrand, MJ; Jimeno, JM; López-Lázaro, L; Manzanares, I; Rosing, H; Schellens, JH; Sparidans, RW; van Kesteren, C; van Oosterom, AT	1
Ames, MM; Kuffel, MJ; Morales, JJ; Reid, JM; Rinehart, KL; Ruben, SL; Squillace, DP	1
Bailly, C; Cuevas, C; David-Cordonnier, MH; Gago, F; Marco, E	1

Trials

1 trial(s) available for ecteinascidin 743 and nsc 638718

Article	Year
Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man. Anti-cancer drugs, 2001, Volume: 12, Issue:8 Topics: Antineoplastic Agents, Alkylating; Area Under Curve; Chromatography, High Pressure Liquid; Dioxoles; Glucuronides; Glucuronosyltransferase; Humans; Isoquinolines; Microsomes, Liver; Plasma; Tetrahydroisoquinolines; Trabectedin	2001

Other Studies

2 other study(ies) available for ecteinascidin 743 and nsc 638718

Article	Year
Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:9 Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bile; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dioxoles; DNA, Complementary; Enzyme Inhibitors; Female; Half-Life; Humans; Immune Sera; Isoquinolines; Male; Marine Toxins; Microsomes, Liver; Molecular Structure; NADP; Oxidoreductases, N-Demethylating; Protein Isoforms; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; Sex Characteristics; Steroid Hydroxylases; Substrate Specificity; Tetrahydroisoquinolines; Trabectedin; Urochordata	2002
Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA. Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23 Topics: Antineoplastic Agents, Alkylating; Binding Sites; Dioxoles; DNA; Isoquinolines; Models, Molecular; Nucleic Acid Conformation; Structure-Activity Relationship; Tetrahydroisoquinolines; Trabectedin	2006

Article

Year

Rat and human liver cytochrome P-450 isoform metabolism of ecteinascidin 743 does not predict gender-dependent toxicity in humans.

Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:9

Topics: Animals; Aryl Hydrocarbon Hydroxylases; Bile; Cytochrome P-450 CYP1A1; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Dioxoles; DNA, Complementary; Enzyme Inhibitors; Female; Half-Life; Humans; Immune Sera; Isoquinolines; Male; Marine Toxins; Microsomes, Liver; Molecular Structure; NADP; Oxidoreductases, N-Demethylating; Protein Isoforms; Rats; Rats, Inbred F344; Recombinant Fusion Proteins; Sex Characteristics; Steroid Hydroxylases; Substrate Specificity; Tetrahydroisoquinolines; Trabectedin; Urochordata

2002

Further insight into the DNA recognition mechanism of trabectedin from the differential affinity of its demethylated analogue ecteinascidin ET729 for the triplet DNA binding site CGA.

Journal of medicinal chemistry, 2006, Nov-16, Volume: 49, Issue:23

Topics: Antineoplastic Agents, Alkylating; Binding Sites; Dioxoles; DNA; Isoquinolines; Models, Molecular; Nucleic Acid Conformation; Structure-Activity Relationship; Tetrahydroisoquinolines; Trabectedin

2006