Page last updated: 2024-09-02

ecteinascidin 743 and methotrexate

ecteinascidin 743 has been researched along with methotrexate in 3 studies

Compound Research Comparison

Studies
(ecteinascidin 743)
Trials
(ecteinascidin 743)
Recent Studies (post-2010)
(ecteinascidin 743)
Studies
(methotrexate)
Trials
(methotrexate)
Recent Studies (post-2010) (methotrexate)
66010240441,5935,66611,969

Protein Interaction Comparison

ProteinTaxonomyecteinascidin 743 (IC50)methotrexate (IC50)
Thymidylate synthase Escherichia coli1.8
nuclear receptor coactivator 3 isoform aHomo sapiens (human)0.211
Toll-like receptor 4Homo sapiens (human)1.04
Fatty-acid amide hydrolase 1Mus musculus (house mouse)0.08
Dihydrofolate reductaseHomo sapiens (human)0.0522
Dihydrofolate reductaseMus musculus (house mouse)0.0331
Dihydrofolate reductase Bos taurus (cattle)0.0348
Dihydrofolate reductaseGallus gallus (chicken)0.0545
Dihydrofolate reductaseEnterococcus faecium0.0014
Dihydrofolate reductaseLacticaseibacillus casei0.0138
Thymidylate synthaseHomo sapiens (human)0.343
5-hydroxytryptamine receptor 2CRattus norvegicus (Norway rat)0.0147
Thymidylate synthaseEscherichia coli K-120.0181
Dihydrofolate reductaseEscherichia coli K-120.1529
Bifunctional dihydrofolate reductase-thymidylate synthasePlasmodium falciparum K10.084
Folate receptor betaHomo sapiens (human)0.1585
5-hydroxytryptamine receptor 2ARattus norvegicus (Norway rat)0.0011
Cytochrome P450 11B1, mitochondrial Bos taurus (cattle)0.0012
Folate receptor alphaHomo sapiens (human)0.2263
Dihydrofolate reductasePneumocystis carinii0.0717
Histidine decarboxylaseRattus norvegicus (Norway rat)0.0014
Trifunctional purine biosynthetic protein adenosine-3Homo sapiens (human)0.01
Bifunctional purine biosynthesis protein ATICHomo sapiens (human)0.01
Delta-type opioid receptorRattus norvegicus (Norway rat)0.003
Mu-type opioid receptorRattus norvegicus (Norway rat)0.003
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.003
Reduced folate transporterHomo sapiens (human)0.012
Dihydrofolate reductaseMycobacterium tuberculosis H37Rv0.0174
Folylpolyglutamate synthase, mitochondrialHomo sapiens (human)3.2
Bifunctional dihydrofolate reductase-thymidylate synthaseToxoplasma gondii0.0547
Bifunctional dihydrofolate reductase-thymidylate synthaseTrypanosoma cruzi0.11
Dihydrofolate reductase Bacillus anthracis0.0136
Dihydrofolate reductaseRattus norvegicus (Norway rat)0.0047
Proton-coupled folate transporterHomo sapiens (human)0.1207

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (66.67)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Lombardo, F; Obach, RS; Waters, NJ1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Bertino, JR; Cordon-Cardo, C; Elisseyeff, Y; Faircloth, G; Jhanwar, S; Jimeno, J; Li, WW; Takahashi, N1

Other Studies

3 other study(ies) available for ecteinascidin 743 and methotrexate

ArticleYear
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Sensitivity of soft tissue sarcoma cell lines to chemotherapeutic agents: identification of ecteinascidin-743 as a potent cytotoxic agent.
    Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:9

    Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blotting, Western; Cell Cycle; Cell Survival; Dioxoles; Dose-Response Relationship, Drug; Doxorubicin; Etoposide; Humans; Inhibitory Concentration 50; Isoquinolines; Methotrexate; Proto-Oncogene Proteins c-bcl-2; Retinoblastoma Protein; Sarcoma; Sensitivity and Specificity; Tetrahydroisoquinolines; Trabectedin; Tumor Cells, Cultured; Tumor Suppressor Protein p53

2001