ecteinascidin 743 has been researched along with dacarbazine in 16 studies
| Studies (ecteinascidin 743) | Trials (ecteinascidin 743) | Recent Studies (post-2010) (ecteinascidin 743) | Studies (dacarbazine) | Trials (dacarbazine) | Recent Studies (post-2010) (dacarbazine) |
|---|---|---|---|---|---|
| 660 | 102 | 404 | 7,556 | 1,463 | 3,429 |
| Protein | Taxonomy | ecteinascidin 743 (IC50) | dacarbazine (IC50) |
|---|---|---|---|
| Matrix metalloproteinase-9 | Homo sapiens (human) | 0.556 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 11 (68.75) | 24.3611 |
| 2020's | 2 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Biron, P; Blay, JY; Ray-Coquard, I | 1 |
| Patel, SR | 1 |
| Bui-Nguyen, B; Italiano, A; Toulmonde, M | 1 |
| Bernasconi, S; Caccuri, AM; Capozzi, O; Chiorino, G; Clivio, L; D'Incalci, M; Damia, G; Di Giandomenico, S; Erba, E; Fossati, A; Fuso Nerini, I; Ganzinelli, M; Grosso, F; Mantovani, R; Marangon, E; Marchini, S; Margison, GP; Pastore, A; Rocchi, M; Romano, M; Sala, F; Tercero, JC; Uboldi, S; Watson, AJ | 1 |
| Manson, SC; Penel, N; Powell, S; Sharma, S; Takyar, S | 1 |
| Grignani, G; MartÃn-Broto, J; Reichardt, P; Schuler, M | 1 |
| Dean, A; Demetri, GD; Elias, A; Ganjoo, K; Hensley, ML; Jones, RL; Khokhar, NZ; Knoblauch, RE; Maki, RG; Milhem, M; Parekh, TV; Park, YC; Patel, SR; Schuetze, SM; Spira, A; Staddon, A; Tawbi, H; Van Tine, BA; von Mehren, M | 1 |
| Cousin, S; Penel, N; Peugniez, C | 1 |
| Badalamenti, G; Bello, E; Casali, PG; Collini, P; Colombo, C; Cominetti, D; D'Incalci, M; Dagrada, GP; Dei Tos, AP; Frapolli, R; Gronchi, A; Morosi, C; Negri, T; Pilotti, S; Provenzano, S; Renne, SL; Saponara, M; Stacchiotti, S; Tortoreto, M; Vincenzi, B; Zaffaroni, N; Zuco, V | 1 |
| Demetri, GD; Elias, A; Hamm, J; Hensley, ML; Jones, RL; Knoblauch, R; Maki, RG; McCarthy, S; Milhem, M; Parekh, T; Patel, S; Schuetze, SM; Van Tine, BA; von Mehren, M; Wang, G | 1 |
| Charlson, J; Chawla, SP; D'Amato, G; Demetri, GD; Forscher, C; Hensley, ML; Kaiser, P; Knoblauch, R; Livingston, M; Maki, RG; McCarthy, S; Parekh, T; Patel, S; Reed, DR; Rushing, D; Ryan, CW; Seth, R; Singh, A; von Mehren, M; Wang, G | 1 |
| Chin, AL; Deresinski, S; Gong, CL; Srinivas, S; Studdert, AL | 1 |
| Corbellari, R; De Luca, R; Nadal, L; Neri, D; Villa, A | 1 |
| Coleman, RL; Demetri, GD; Herzog, TJ; Hu, P; Jones, RL; Knoblauch, R; McGowan, T; Monk, BJ; Patel, SR; Schuetze, SM; Shalaby, W; Triantos, S; Van Tine, BA; von Mehren, M | 1 |
4 review(s) available for ecteinascidin 743 and dacarbazine
| Article | Year |
|---|---|
[High-dose chemotherapy in soft tissue sarcomas of adults].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Dacarbazine; Dioxoles; Dose-Response Relationship, Drug; Doxorubicin; Hematopoietic Stem Cell Transplantation; Humans; Ifosfamide; Isoquinolines; Sarcoma; Tetrahydroisoquinolines; Trabectedin | 2001 |
Developing therapeutic pharmaceuticals for the treatment of soft-tissue sarcomas.
Topics: Antineoplastic Agents; Benzamides; Camptothecin; Dacarbazine; Deoxycytidine; Dioxoles; Gemcitabine; Humans; Imatinib Mesylate; Irinotecan; Isoquinolines; Piperazines; Pyrimidines; Sarcoma; Temozolomide; Tetrahydroisoquinolines; Trabectedin | 2002 |
[Chemotherapy options for patients with advanced soft-tissue sarcoma beyond anthracyclines].
Topics: Antineoplastic Agents; Dacarbazine; Deoxycytidine; Dioxoles; Docetaxel; Doxorubicin; Gemcitabine; Humans; Ifosfamide; Leiomyosarcoma; Liposarcoma; Sarcoma; Soft Tissue Neoplasms; Taxoids; Tetrahydroisoquinolines; Trabectedin | 2010 |
Efficacy and safety of pharmacological interventions in second- or later-line treatment of patients with advanced soft tissue sarcoma: a systematic review.
Topics: Antineoplastic Agents; Dacarbazine; Deoxycytidine; Dioxoles; Gemcitabine; Humans; Indazoles; Pyrimidines; Randomized Controlled Trials as Topic; Sarcoma; Sulfonamides; Tetrahydroisoquinolines; Trabectedin; Treatment Failure | 2013 |
3 trial(s) available for ecteinascidin 743 and dacarbazine
| Article | Year |
|---|---|
Efficacy and Safety of Trabectedin or Dacarbazine for Metastatic Liposarcoma or Leiomyosarcoma After Failure of Conventional Chemotherapy: Results of a Phase III Randomized Multicenter Clinical Trial.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dacarbazine; Dioxoles; Disease-Free Survival; Drug Administration Schedule; Female; Humans; Leiomyosarcoma; Liposarcoma; Male; Middle Aged; Survival Rate; Tetrahydroisoquinolines; Trabectedin; Young Adult | 2016 |
Efficacy and tolerability of trabectedin in elderly patients with sarcoma: subgroup analysis from a phase III, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma.
Topics: Administration, Intravenous; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Dacarbazine; Drug Administration Schedule; Female; Humans; Kaplan-Meier Estimate; Leiomyosarcoma; Liposarcoma; Male; Middle Aged; Progression-Free Survival; Time Factors; Trabectedin; Young Adult | 2018 |
Overall survival and histology-specific subgroup analyses from a phase 3, randomized controlled study of trabectedin or dacarbazine in patients with advanced liposarcoma or leiomyosarcoma.
Topics: Aged; Antineoplastic Agents, Alkylating; Dacarbazine; Female; Humans; Leiomyosarcoma; Liposarcoma; Male; Survival Analysis; Trabectedin | 2019 |
9 other study(ies) available for ecteinascidin 743 and dacarbazine
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
Characterization of a new trabectedin-resistant myxoid liposarcoma cell line that shows collateral sensitivity to methylating agents.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; C-Reactive Protein; CCAAT-Enhancer-Binding Protein-alpha; CCAAT-Enhancer-Binding Protein-beta; Cell Line, Tumor; Dacarbazine; Dioxoles; DNA Methylation; DNA Modification Methylases; DNA Repair; DNA Repair Enzymes; Drug Resistance, Neoplasm; Fibronectins; Humans; Liposarcoma, Myxoid; Oncogene Proteins, Fusion; Promoter Regions, Genetic; RNA-Binding Protein FUS; Serum Amyloid P-Component; Signal Transduction; Temozolomide; Tetrahydroisoquinolines; Trabectedin; Transcription Factor CHOP; Tumor Suppressor Proteins; Ultraviolet Rays | 2012 |
Trabectedin clinical cases: use according to indication in diverse clinical scenarios.
Topics: Anthracyclines; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Contraindications; Dacarbazine; Deoxycytidine; Dioxoles; Female; Femoral Neoplasms; Gemcitabine; Humans; Hysterectomy; Ifosfamide; Leiomyosarcoma; Lung Neoplasms; Male; Middle Aged; Neoadjuvant Therapy; Radionuclide Imaging; Remission Induction; Salvage Therapy; Sarcoma; Sarcoma, Synovial; Soft Tissue Neoplasms; Tetrahydroisoquinolines; Thigh; Tomography, X-Ray Computed; Trabectedin; Treatment Outcome; Uterine Neoplasms | 2015 |
Trabectedin is an effective second-line treatment in soft tissue sarcoma patients.
Topics: Dacarbazine; Dioxoles; Disease-Free Survival; Humans; Sarcoma; Tetrahydroisoquinolines; Trabectedin | 2016 |
Patient-derived solitary fibrous tumour xenografts predict high sensitivity to doxorubicin/dacarbazine combination confirmed in the clinic and highlight the potential effectiveness of trabectedin or eribulin against this tumour.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Blotting, Western; Cerebellar Neoplasms; Dacarbazine; Dioxoles; Disease-Free Survival; Doxorubicin; Female; Furans; Humans; Ifosfamide; Ketones; Kidney Neoplasms; Male; Meningeal Neoplasms; Mice, SCID; Middle Aged; Pleural Neoplasms; Response Evaluation Criteria in Solid Tumors; Retroperitoneal Neoplasms; Retrospective Studies; Soft Tissue Neoplasms; Solitary Fibrous Tumors; Survival Rate; Tetrahydroisoquinolines; Trabectedin; Xenograft Model Antitumor Assays | 2017 |
Application of pharmacoeconomics to formulary management in a health system setting.
Topics: Academic Medical Centers; Clinical Trials as Topic; Cost-Benefit Analysis; Dacarbazine; Drug Approval; Drug Costs; Drug Utilization Review; Economics, Pharmaceutical; Formularies as Topic; Humans; Interdisciplinary Communication; Markov Chains; Models, Economic; Neoplasms; Pharmaceutical Services; Pharmacy and Therapeutics Committee; Trabectedin; Treatment Outcome; United States; United States Food and Drug Administration | 2019 |
The immunocytokine L19-TNF eradicates sarcomas in combination with chemotherapy agents or with immune check-point inhibitors.
Topics: Animals; Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Proliferation; Dacarbazine; Female; Humans; Immune Checkpoint Inhibitors; Mice; Mice, Inbred BALB C; Recombinant Fusion Proteins; Sarcoma; Trabectedin; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2020 |
Cardiac safety of trabectedin monotherapy or in combination with pegylated liposomal doxorubicin in patients with sarcomas and ovarian cancer.
Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Cardiotoxicity; Cardiovascular Diseases; Child; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Dacarbazine; Doxorubicin; Female; Heart; Humans; Male; Middle Aged; Multivariate Analysis; Neoplasm Recurrence, Local; Ovarian Neoplasms; Polyethylene Glycols; Product Surveillance, Postmarketing; Retrospective Studies; Sarcoma; Soft Tissue Neoplasms; Stroke Volume; Trabectedin; Ventricular Function, Left; Young Adult | 2021 |