Page last updated: 2024-09-04

eckol and dieckol

eckol has been researched along with dieckol in 20 studies

Compound Research Comparison

Studies
(eckol)
Trials
(eckol)
Recent Studies (post-2010)
(eckol)
Studies
(dieckol)
Trials
(dieckol)
Recent Studies (post-2010) (dieckol)
4703297282

Protein Interaction Comparison

ProteinTaxonomyeckol (IC50)dieckol (IC50)
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus2.7
Beta-secretase 1Homo sapiens (human)2.21

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (25.00)29.6817
2010's14 (70.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Ishimaru, A; Okada, Y; Okuyama, T; Suzuki, R1
Kim, MM; Kim, SK; Lee, SH; Li, Y; Qian, ZJ; Ryu, B1
Choi, JS; Jung, HA; Oh, SH1
Bae, JS; Kim, TH; Ku, SK; Lee, T2
Jeong, HJ; Kim, D; Kim, JH; Kim, YM; Kwon, HJ; Kwon, JM; Lee, WS; Park, JY; Ryu, YB1
Cao, W; Jian, Y; Ju, X; Li, H; Liang, C; Liu, H; Liu, Y; Ren, X; Tian, L; Wang, Y; Xie, X; Xin, L; Zhang, D; Zhao, Q1
Choi, HY; Joe, MJ; Kang, DW; Kim, SN; Kim, YK; Park, GM; Shin, WS1
Chen, T; Hwang, H; Nines, RG; Shin, HC; Stoner, GD1
Choi, JS; Chung, HY; Kim, HR; Yoon, NY1
Choi, JS; Goo, HR; Na, DH1
Ahn, BR; Choi, JS; Chowdhury, SS; Islam, N; Jung, HA; Moon, HE; Sohn, HS1
Eom, SH; Kim, TH; Kim, YM; Lee, EW; Lee, MS1
Bae, JS; Kim, TH; Ku, SK1
Cha, SH; Jeon, YJ; Kang, MC; Kang, SM; Kim, EA; Lee, SH; Song, CB; Wijesinghe, WA1
Choi, JS; Choung, SY; Jung, HA; Kim, JI1
Choi, JS; Jung, HA; Jung, JH; Roy, A1
Ahn, MR; Jun, M; Kim, DH; Kim, OY; Lee, S; Yoon, E; Youn, K1
Jun, M; Lee, J1
Choi, JS; Jung, HA; Paudel, P; Seong, SH1

Reviews

1 review(s) available for eckol and dieckol

ArticleYear
The development of Coronavirus 3C-Like protease (3CL
    European journal of medicinal chemistry, 2020, Nov-15, Volume: 206

    Topics: Antiviral Agents; Coronavirus 3C Proteases; Cysteine Endopeptidases; Humans; Peptidomimetics; Protease Inhibitors; Viral Nonstructural Proteins

2020

Other Studies

19 other study(ies) available for eckol and dieckol

ArticleYear
A new phloroglucinol derivative from the brown alga Eisenia bicyclis: potential for the effective treatment of diabetic complications.
    Journal of natural products, 2004, Volume: 67, Issue:1

    Topics: alpha-Amylases; Diabetes Mellitus; Enzyme Inhibitors; Glycation End Products, Advanced; Japan; Molecular Structure; Phaeophyceae; Phloroglucinol

2004
Chemical components and its antioxidant properties in vitro: an edible marine brown alga, Ecklonia cava.
    Bioorganic & medicinal chemistry, 2009, Mar-01, Volume: 17, Issue:5

    Topics: Animals; Antioxidants; Cell Line; Dioxins; Free Radical Scavengers; HL-60 Cells; Humans; Mice; Phaeophyceae; Reactive Oxygen Species; Sterols; Structure-Activity Relationship; Tannins

2009
Molecular docking studies of phlorotannins from Eisenia bicyclis with BACE1 inhibitory activity.
    Bioorganic & medicinal chemistry letters, 2010, Jun-01, Volume: 20, Issue:11

    Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Enzyme Inhibitors; Kinetics; Models, Molecular; Tannins

2010
Vascular barrier protective effects of eckol and its derivatives.
    Bioorganic & medicinal chemistry letters, 2012, Jun-01, Volume: 22, Issue:11

    Topics: Acetic Acid; Animals; Carboxymethylcellulose Sodium; Cell Membrane Permeability; Cell Movement; Dioxins; Human Umbilical Vein Endothelial Cells; Humans; Leukocytes; Lipopolysaccharides; Mice; Protective Agents

2012
Dieckol, a SARS-CoV 3CL(pro) inhibitor, isolated from the edible brown algae Ecklonia cava.
    Bioorganic & medicinal chemistry, 2013, Jul-01, Volume: 21, Issue:13

    Topics: Antiviral Agents; Benzofurans; Cysteine Proteases; Cysteine Proteinase Inhibitors; Humans; Molecular Docking Simulation; Phaeophyceae; Quantitative Structure-Activity Relationship; Severe Acute Respiratory Syndrome; Severe acute respiratory syndrome-related coronavirus

2013
The inhibitory effects of eckol and dieckol from Ecklonia stolonifera on the expression of matrix metalloproteinase-1 in human dermal fibroblasts.
    Biological & pharmaceutical bulletin, 2006, Volume: 29, Issue:8

    Topics: Base Sequence; Benzofurans; Blotting, Western; Cells, Cultured; Dioxins; DNA Primers; Fibroblasts; Humans; Matrix Metalloproteinase 1; Phaeophyceae; Reverse Transcriptase Polymerase Chain Reaction; Skin

2006
Photochemoprevention of UVB-induced skin carcinogenesis in SKH-1 mice by brown algae polyphenols.
    International journal of cancer, 2006, Dec-15, Volume: 119, Issue:12

    Topics: Administration, Cutaneous; Administration, Oral; Animals; Benzofurans; Blotting, Western; Cell Proliferation; Cyclooxygenase 2; Dinoprostone; Dioxins; Epidermis; Female; Flavonoids; Gene Expression; Immunohistochemistry; Mice; Molecular Structure; Neoplasms, Radiation-Induced; Phaeophyceae; Phenols; Polyphenols; Proliferating Cell Nuclear Antigen; Random Allocation; Reverse Transcriptase Polymerase Chain Reaction; Skin; Skin Neoplasms; Ultraviolet Rays

2006
Anti-hyperlipidemic effect of an edible brown algae, Ecklonia stolonifera, and its constituents on poloxamer 407-induced hyperlipidemic and cholesterol-fed rats.
    Archives of pharmacal research, 2008, Volume: 31, Issue:12

    Topics: Animals; Benzofurans; Cholesterol, Dietary; Diet; Dioxins; Ethanol; Freeze Drying; Hyperlipidemias; Hypolipidemic Agents; Male; Phaeophyceae; Poloxamer; Rats; Rats, Sprague-Dawley; Solvents; Tannins; Triglycerides

2008
Quantitative determination of major phlorotannins in Ecklonia stolonifera.
    Archives of pharmacal research, 2010, Volume: 33, Issue:4

    Topics: Benzofurans; Chromatography, High Pressure Liquid; Dioxins; Phaeophyceae; Plants, Medicinal; Spectrometry, Mass, Electrospray Ionization; Tannins

2010
Protein tyrosine phosphatase 1B and α-glucosidase inhibitory Phlorotannins from edible brown algae, Ecklonia stolonifera and Eisenia bicyclis.
    Bioscience, biotechnology, and biochemistry, 2011, Volume: 75, Issue:8

    Topics: alpha-Glucosidases; Benzofurans; Blood Glucose; Complex Mixtures; Diabetes Mellitus; Dioxins; Enzyme Inhibitors; Glycoside Hydrolase Inhibitors; Humans; Hyperglycemia; Hypoglycemic Agents; Kinetics; Magnetic Resonance Spectroscopy; Phaeophyceae; Phloroglucinol; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Solutions; Spectrophotometry; Tannins; Yeasts

2011
Pancreatic lipase inhibitory activity of phlorotannins isolated from Eisenia bicyclis.
    Phytotherapy research : PTR, 2013, Volume: 27, Issue:1

    Topics: Animals; Benzofurans; Dioxins; Inhibitory Concentration 50; Lipase; Oxindoles; Phaeophyceae; Swine; Tannins

2013
Vascular barrier protective effects of phlorotannins on HMGB1-mediated proinflammatory responses in vitro and in vivo.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2012, Volume: 50, Issue:6

    Topics: Animals; Benzofurans; Blood Vessels; Blotting, Western; Cell Adhesion Molecules; Cell Membrane Permeability; Cell Movement; Cell Survival; Dioxins; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Epithelial Cells; Female; HMGB1 Protein; Humans; Inflammation; Kelp; Lipopolysaccharides; Mice; Mice, Inbred ICR; Phloroglucinol; Spectrometry, Mass, Electrospray Ionization; Tannins; Toll-Like Receptor 4

2012
Antithrombotic and profibrinolytic activities of eckol and dieckol.
    Journal of cellular biochemistry, 2012, Volume: 113, Issue:9

    Topics: Animals; Benzofurans; Dioxins; Enzyme-Linked Immunosorbent Assay; Factor Xa; Fibrinolysis; Fibrinolytic Agents; Human Umbilical Vein Endothelial Cells; Humans; Male; Mice; Mice, Inbred ICR; Prothrombin; Thrombin; Tissue Plasminogen Activator; Tumor Necrosis Factor-alpha

2012
Protective effect of marine algae phlorotannins against AAPH-induced oxidative stress in zebrafish embryo.
    Food chemistry, 2013, Jun-01, Volume: 138, Issue:2-3

    Topics: Amidines; Animals; Antioxidants; Benzofurans; Dioxins; Oxidative Stress; Phaeophyceae; Phloroglucinol; Protective Agents; Zebrafish

2013
Protective effect of the edible brown alga Ecklonia stolonifera on doxorubicin-induced hepatotoxicity in primary rat hepatocytes.
    The Journal of pharmacy and pharmacology, 2014, Volume: 66, Issue:8

    Topics: Animals; Benzofurans; Dioxins; Doxorubicin; Hepatocytes; Male; Phaeophyceae; Phloroglucinol; Protective Agents; Rats; Rats, Sprague-Dawley; Seaweed

2014
Evaluation of the inhibitory effects of eckol and dieckol isolated from edible brown alga Eisenia bicyclis on human monoamine oxidases A and B.
    Archives of pharmacal research, 2017, Volume: 40, Issue:4

    Topics: Benzofurans; Dioxins; Dose-Response Relationship, Drug; Humans; Molecular Docking Simulation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Phaeophyceae; Structure-Activity Relationship

2017
Anti-Neuroinflammatory Property of Phlorotannins from
    Marine drugs, 2018, Dec-22, Volume: 17, Issue:1

    Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Apoptosis; Benzofurans; Cyclooxygenase 2; Dioxins; Down-Regulation; Drug Evaluation, Preclinical; MAP Kinase Signaling System; Neuroprotective Agents; NF-kappa B; Nitric Oxide Synthase Type II; PC12 Cells; Peptide Fragments; Phaeophyceae; Rats; Seaweed

2018
Dual BACE1 and Cholinesterase Inhibitory Effects of Phlorotannins from
    Marine drugs, 2019, Feb-01, Volume: 17, Issue:2

    Topics: ADAM17 Protein; Alzheimer Disease; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Benzofurans; Cholinesterase Inhibitors; Cholinesterases; Dioxins; Molecular Docking Simulation; Seaweed; Tannins

2019
Identifying Phlorofucofuroeckol-A as a Dual Inhibitor of Amyloid-β
    Marine drugs, 2019, Oct-23, Volume: 17, Issue:11

    Topics: Amyloid beta-Peptides; Benzofurans; Dioxins; Glycation End Products, Advanced; Lipid Peroxidation; Molecular Docking Simulation; Molecular Structure; Phaeophyceae; Phloroglucinol; Protein Aggregation, Pathological

2019