ebastine and piperidines

ebastine has been researched along with piperidines in 182 studies

Research

Studies (182)

TimeframeStudies, this research(%)All Research%
pre-19903 (1.65)18.7374
1990's68 (37.36)18.2507
2000's74 (40.66)29.6817
2010's27 (14.84)24.3611
2020's10 (5.49)2.80

Authors

AuthorsStudies
Hopes, H; Leopold, G; Meuret, GH; Ungethüm, W; Wiemann, H1
Kuitunen, T; Mattila, MJ; Plétan, Y1
Despontin, K; Ghys, L; Lachapelle, JM; Rihoux, JP; Rivest, J1
Cadahia García, A; Cano Cantudo, L; Cisteró Bahima, A; Picado Vallés, C; Sanz Amaro, A; Zayas Sanza, JM1
Holgate, ST; Wood-Baker, R1
Ankier, SI; Warrington, SJ1
Liminana, R; Meredith, PA; Reid, JL; Vincent, J1
Reid, JL; Sumner, DJ; Vincent, J1
Imano, K; Ishii, K; Karasawa, T; Nakamura, H; Seto, Y; Takeyama, K; Yakuo, I1
O'Hanlon, JF; Ramaekers, JG1
Bucher, B; Buchmeier, A; Garcia, J; Nelson, HS; Oppenheimer, J1
Ter Laak, AM; Timmerman, H; Walczynski, K; Zhang, MQ1
Fujii, T; Matsuda, M; Mizuki, Y; Sakashita, M; Sekine, Y; Yamaguchi, T1
Fujii, T; Hashizume, T; Matsuda, M; Nakashima, M; Sakashita, M; Sekine, Y; Uematsu, T; Yamaguchi, T1
de la Cuadra, J; Roma, J; Teixidó, P; Teruel, M1
Amejima, H; Fujii, T; Hatoyama, T; Kagemoto, A; Matsumoto, S; Miyazaki, H; Nakao, M; Tanaka, K1
Fujii, T; Hatoyama, T; Matsumoto, S; Miyazaki, H; Nomura, N; Tagawa, M; Tanaka, K1
Fujii, T; Hatoyama, T; Kagemoto, A; Miyazaki, H; Naruto, S; Yoshida, K1
Blanco, M; Coello, J; González, F; Iturriaga, H; Maspoch, S; Tomás, X1
Jansat, JM; Martinez-Tobed, A; Puigdemont, A; Queralt, M1
Simons, FE; Simons, KJ; Watson, WT1
Aranko, K; Kuitunen, T; Mattila, MJ1
Breimer, DD; Bruno, R; Cohen, AF; Reinhoudt, JF; Schoemaker, HC; Van Rooij, J1
Brookhuis, KA; De Vries, G; De Waard, D1
Timmerman, H; Walczynski, K; Zhang, MQ1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W2
Bremard-Oury, C; Gehanno, P; Zeisser, P1
Faulds, D; Wiseman, LR1
Roberts, DJ6
Storms, WW1
Cohen, B; Gehanno, P1
Kalis, B1
Peláez, A1
Conde Hernández, DJ; Delgado Romero, J; Palma Aqilar, JL1
Böttcher, H; Hochstätter, H; Liebig-Weber, A; Schwartz, H1
Bousquet, J; Bremard-Oury, C; Campbell, A; Crampette, L; Michel, FB1
Jansat, JM; Lastra, CF; March, MA; Mariño, EL1
Benavente, V; Botey, J; Eseverri, JL; Marin, A1
Timmerman, H; Zhang, MQ1
Ducic, I; Fan, J; Ko, CM; Morad, M; Shuba, YM1
Llenas, J; Roberts, DJ1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Sherwood, J1
Delpón, E; Franqueza, L; Gay, P; Tamargo, J; Valenzuela, C; Vicente, J1
Brummer-Korvenkontio, H; Palosuo, T; Petman, L; Reunala, T; Sarna, S1
Fujii, T; Hatoyama, T; Matsumoto, S; Miyazaki, H1
Volkerts, ER1
Benabdesselam, O; Frossard, N; Melac, M; Pauli, G1
Luss, LV1
Charpentier, JC; Didier, A; Melac, M; Murris-Espin, M1
Fujii, T; Hashizume, T; Inaba, T; Mise, M; Miyazaki, H; O, L; Terauchi, Y1
Leroy, T; Tasset, C; Valentin, B; Van Neste, D1
Fischer, H; Gottschlich, R; Seelig, A1
Balabolkin, II; Blokhin, BM; Goriachkina, LA; Il'ina, NI; Kolganova, NA; Pampura, AN; Sidorenko, IV1
Bousquet, J1
Argenti, D; Garcia, J; Heald, D; Huang, MY; Wilson, J1
Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y1
Mattila, MJ; Paakkari, I1
Bousquet, J; Gaudaño, EM; Palma Carlos, AG; Staudinger, H1
Danielson, L; DeVos, C; Grant, JA; Rihoux, JP1
Gispert, J; Roberts, DJ1
Chaikin, P; Garcia, JD; Gillen, M; Morganroth, J; Moss, AJ; Roberts, DJ1
Hanada, E; Hirota, M; Iga, T; Kotaki, H; Nakaya, H; Ohtani, H; Sato, H; Sawada, Y; Uemura, H1
Benabdesselam, O; Duvernelle, C; Frossard, N; Melac, M; Pauli, G; Purohit, A1
López, M; Palacios, JM; Roberts, DJ; Ryder, H; Segarra, V1
Luria, X1
Morganroth, J; Moss, AJ1
Hurst, M; Spencer, CM1
Georges, GC; Lim, JC; Ratner, PH1
Fujii, T; Funae, Y; Hashizume, T; Hiroi, T; Imaoka, S; Kamataki, T; Miyazaki, H; Terauchi, Y1
Cho, W; Fujimura, M; Kim, KP; Kita, T; Kurashima, K; Leff, AR; Munoz, NM; Myou, S; Nakao, S; Nonomura, A; Sano, H; Shioya, T; Zhu, X1
Kido, Y; Sai, Y; Tamai, I; Tsuji, A; Yamashita, J1
Malik, M2
Fujii, T; Funae, Y; Hashizume, T; Imaoka, S; Kamataki, T; Matsumoto, S; Mise, M; Miyazaki, H; Terauchi, Y1
Aubeneau, M; Gillen, M; Jan, C; Jensen, BK; Pandit, B; Rhodes, G; Rohatagi, S1
Matsuda, M; Mizuki, Y; Terauchi, Y1
Frossard, N; Mounedji, N; Valleteau, A; Vital-Durand, D1
Chaikin, P; Gillen, MS; Miller, B; Morganroth, J1
Hashida, M; Imamura, Y; Shimizu, K; Takakura, Y; Yamaoka, K; Yamashita, F1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M1
Arai, H; Fujii, T; Higuchi, M; Ido, T; Itoh, M; Iwata, R; Kano, M; Komemushi, S; Matsuda, M; Mizuki, Y; Okamura, N; Sasaki, H; Tagawa, M; Watanabe, T; Yanai, K1
Fujii, T; Funae, Y; Hashizume, T; Imaoka, S; Kamataki, T; Mise, M; Miyazaki, H; Terauchi, Y1
DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM1
Arai, H; Fujii, T; Higuchi, M; Itoh, M; Kano, M; Komemushi, S; Matsuda, M; Mizuki, Y; Okamura, N; Sasaki, H; Tagawa, M; Watanabe, T; Yanai, K1
Ito, T; Yabuuchi, M; Yakuo, I1
Shamsi, Z1
Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE1
Asaka, H; Baba, K; Yoshida, H1
Burri, P; Karppinen, A; Kautiainen, H; Petman, L; Reunala, T1
Paakkari, I1
Alemán, AM; Cuesta, J; Novalbos, A; Quirce, S; Sastre, J1
Antonijoan, R; Barbanoj, M; Esbrí, R; Garcia, E; Gich, I; Gispert, J; Luria, X1
Frank, H; George, G; Gillen, M; Lim, J; Rohatagi, SS1
Hirama, T; Matsubara, T; Matsumoto, S; Nagata, K; Yamazoe, Y1
Fujisaki, Y; Itoh, Y; Oishi, R1
Kamei, J; Miyata, S; Morita, K; Onodera, K1
Gras, J; Llenas, J; Llupià, J1
Gispert, J; Hampel, F; Ratner, P1
Boyce, M; Carey, W; Luria, X; Warrington, S1
Bousquet, J; Bremard-Oury, C; El-Akkad, T; Lund, VJ; Mounedji, N; Stevens, MT; van Cauwenberge, P1
Dang, NH; Hosono, O; Iwata, S; Kawasaki, H; Kobayashi, H; Kobayashi, S; Morimoto, C; Munakata, Y; Nori, M; Shiohara, T; Tanaka, H; Umezawa, Y1
Antonijoan, RM; Barbanoj, MJ; Esbrí, R; Garcia, E; García-Gea, C; Gich, I; Gispert, J; Luria, X; Morte, A1
Morimoto, C1
Appajosyula, S; Gelfand, EW; Meeves, S1
Dilzer, SC; Lasseter, KC; Noveck, RJ; Vargas, R; Waldman, S1
Hampel, F; Howland, W; Ratner, P; Van Bavel, J2
Castillo, JA; De Molina, M; Guadaño, EM; Meseguer, J; Picado, C; Serra-Batlles, J; Valero, A1
De Belder, T; Sys, L; Van Cauwenberge, P1
Buisson, D; Jaouen, M; Mazier, C; Sari, MA1
Kang, W; Liu, KH; Ryu, JY; Shin, JG1
Chaikin, P; Gillen, MS; Malik, M; Pentikis, H; Rhodes, GR; Roberts, DJ1
Cadahía, A; Cardona, V; Guilarte, M; Muñoz-Cano, R1
Jeong, HE; Lee, SS; Liu, KH; Moon, T; Oh, SJ; Ryu, JY; Shin, JG; Yoon, CN; Yun, CH1
Al-Amood, S; Elming, H1
Chuecos, F; Esbrí, R; Falqués, M; Gispert, J; Luria, X; Peris, F; Ratner, P; Rosales, MJ1
Benitez, J; Caballero, MJ; Carrillo, JA; Gervasini, G; Vizcaino, S1
Choi, CS; Choi, YK; Desta, Z; Kim, MG; Kim, MJ; Lee, DJ; Liu, KH; Shin, JG; Shon, JH; Yoon, YJ1
Codreanu, A; de Chillou, C; Moneret-Vautrin, DA1
Chen, X; Deng, Y; Li, H1
Noveck, RJ; Preston, RA; Swan, SK1
Antonijoan, RM; Barbanoj, MJ; Esbri, R; Fortea, J; García-Gea, C; Puntes, M; Valle, M1
Köberlein, J; Mösges, R1
Antonijoan, R; Barbanoj, MJ; Esbrí, R; Fortea, J; García-Gea, C; Pérez, J; Puntes, M; Serra, C1
Bridges, AS; Hall, JE; Kornbluth, S; Paine, MF; Tidwell, RR; Wang, MZ; Wu, JQ; Zeldin, DC1
Lopatin, AS; Petrovskaia, TIu; Sergeeva, TA1
Magerl, M; Maurer, M; Metz, M; Schmolke, J; Siebenhaar, F; Zuberbier, T2
Arias Irigoyen, J; Benavente Fernández, A; Talavera Fabuel, A1
Cheng, J; Jiang, H; Li, W; Liu, H; Tang, Y; Zhu, W1
Devillier, P1
Fukui, H; Izumi, N; Mizuguchi, H; Ogino, S; Umehara, H1
de Barrio, M; Fuentes, V; Herrero, T; Sánchez, I; Tornero, P; Zubeldia, J1
Sastre, J2
Dundua, MM; Tsiskarishvili, NI; Tsiskarishvili, NV1
Allaf, B; Bodez, T; Bousquet, J; Gehano, P; Janin, N; Klossek, JM; Le Gal, M; Liard, F; Neukirch, F1
Cha, IJ; Lee, SS; Liu, KH; Shin, JG; Shon, JH; Yeo, CW1
Amagai, M; Ohyama, M; Shimizu, A; Tanaka, K1
Cauley, M; Cousins, V; Hampton, D; Levin, ED; Petro, A; Pruitt, M; Rose, J; Slade, S; Wells, C1
Broccatelli, F; Carosati, E; Cruciani, G; Frosini, M; Goracci, L; Neri, A; Oprea, TI1
Laguna Martínez, JJ; Reaño Martos, M; Rojas Pérez-Ezquerra, P; Sánchez Morillas, L; Sanz, ML1
Bednarek, T; Elitzer, S; Kang, W; Noh, K; Weiss, M1
Jang, YJ; Kim, HC; Kim, JH; Lee, JH1
Fukui, H; Hattori, M; Kitamura, Y; Kuroda, W; Mizuguchi, H; Ogishi, H; Takeda, N1
Antczak, C; Bhinder, B; Calder, PA; Djaballah, H; Mahida, JP1
Molnár, I; Schmidt, AH1
Das, A; Magnetta, E; McDougle, DR; Meling, DD; Palaria, A1
Bekkali, N; Boeckxstaens, GE; de Jonge, WJ; Shi, J; Stanisor, OI; van den Wijngaard, RM; van Diest, SA; Welting, O; Yu, Z1
Braido, F; Canonica, GW; Ferrando, M; Sclifò, F1
Ibrahim, FA; Wahba, ME1
Bonny, M; Goethals, L; Kindts, I; Planckaert, N; Stellamans, K1
Abdulaeva, SN; Gadzhimirzaev, GA; Gadzhimirzaeva, RG; Shakhnazarov, MA1
Awasthi, A; Ghosh, K; Navalgund, SG; Pandey, AK; Raju, ChK; Rapolu, R; Srinivas, K; Surendranath, KV1
Alpizar, YA; Augustijns, P; Balemans, D; Belmans, A; Boeckxstaens, GE; Bulmer, DC; Carmeliet, P; Cibert-Goton, V; Cirillo, C; Dooley, J; Ghesquière, B; Hellings, PW; Kortekaas, I; Liston, A; Mols, R; Nasser, Y; Peetermans, WE; Rutgeerts, P; Talavera, K; Valdez-Morales, EE; Van der Merwe, S; Van Veldhoven, PP; Van Wanrooy, S; Vanbrabant, W; Vanden Berghe, P; Vanner, S; Vermeire, S; Wouters, MM1
Inoue, T; Sasaki, E; Uehara, S; Uno, Y; Yamazaki, H; Yuki, Y1
Ibrahim, F; Wahba, ME1
Boeckxstaens, G; Camilleri, M1
Frare, RG; Singh, AK1
Gaudette, F; Huguet, J; Michaud, V; Turgeon, J1
Jee, JG; Lee, J; Liu, KH; Park, SH; Phuc, NM; Shon, JC1
Cui, L; Guan, K; Li, LS; Wang, RQ1
André, F; Dansette, PM; Graves, JP; Lafite, P; Mansuy, D; Zeldin, DC1
Chen, ML; Lee, MC; Li, CH; Lin, YY; Tsai, FM; Wang, CH; Wang, LK1
Kamura, S; Kawasaki, H; Murashima, A; Ozawa, K; Sago, H; Saito, J; Sandaiji, N; Suzuki, T; Wada, S; Yagishita, S; Yakuwa, N; Yamatani, A1
Hifumi, H; Hirai, D; Itai, S; Iwao, Y; Kitamura, R; Ohara, M; Takeuchi, M; Tsunematsu, H1
Angelone, T; Avolio, E; Barbieri, A; Botti, G; De Bartolo, A; De Lorenzo, A; Gualtieri, P; Palma, G; Pasqua, T; Rocca, C; Silvestri, G1
Chen, LY; Xu, L1
Abbas, G; Ibrahim, HM; Ikram, M; Inam, S; Iqbal, MS; Irfan, M; Islam, N; Khan, IU; Mushtaq, M; Rasul, A; Rehman, MU; Syed, HK; Zahoor, AF1
Abualsunun, WA; Alharbi, WS; Ali, A; Almehmady, AM; Bakhaidar, RB; Halwani, AA; Hosny, KM; Iqbal, M; Khan, BA; Khan, MK; Murshid, SSA1
Chen, Q; Hao, F; Li, S; Qian, T; Song, Z; Zhang, D1
Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H1
Sert, S1

Reviews

23 review(s) available for ebastine and piperidines

ArticleYear
Ebastine. a review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders.
    Drugs, 1996, Volume: 51, Issue:2

    Topics: Animals; Butyrophenones; Histamine H1 Antagonists; Humans; Hypersensitivity; Piperidines

1996
A preclinical overview of ebastine. Studies on the pharmacological properties of a novel histamine H1 receptor antagonist.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Animals; Butyrophenones; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Piperidines

1996
Towards the optimal antihistamine: studies with ebastine.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1998, Volume: 47 Suppl 1

    Topics: Animals; Bronchoconstriction; Butyrophenones; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Piperidines; Potassium Channels; Rats; Structure-Activity Relationship; Terfenadine

1998
Antihistamines in severe/chronic rhinitis.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1998, Volume: 28 Suppl 6

    Topics: Butyrophenones; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Torsades de Pointes

1998
Variations among non-sedating antihistamines: are there real differences?
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:2

    Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine

1999
The non-cardiac systemic side-effects of antihistamines: ebastine.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3

    Topics: Animals; Brain; Butyrophenones; Histamine H1 Antagonists; Humans; Piperidines; Psychomotor Performance

1999
A review of the cardiac systemic side-effects of antihistamines: ebastine.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 1999, Volume: 29 Suppl 3

    Topics: Adult; Butyrophenones; Child; Clinical Trials as Topic; Drug Interactions; Erythromycin; Heart; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines

1999
Assessing the cardiac safety of ebastine. Prologue.
    Drug safety, 1999, Volume: 21 Suppl 1

    Topics: Animals; Butyrophenones; Histamine H1 Antagonists; Humans; Long QT Syndrome; Piperidines; Torsades de Pointes

1999
Cardiac effects of ebastine and other antihistamines in humans.
    Drug safety, 1999, Volume: 21 Suppl 1

    Topics: Aged; Butyrophenones; Child; Drug Interactions; Electrocardiography; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines

1999
Assessing the cardiac safety of ebastine. Epilogue.
    Drug safety, 1999, Volume: 21 Suppl 1

    Topics: Animals; Butyrophenones; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG

1999
Ebastine: an update of its use in allergic disorders.
    Drugs, 2000, Volume: 59, Issue:4

    Topics: Animals; Anti-Allergic Agents; Butyrophenones; Humans; Hypersensitivity; Piperidines

2000
[The effect of second generation histamine antagonists on the heart].
    Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4

    Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes

2001
Cardiotoxicity of new antihistamines and cisapride.
    Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3

    Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine

2002
[Effect of H1 histamine receptor antagonists on T cell functions].
    Arerugi = [Allergy], 2003, Volume: 52, Issue:11

    Topics: Animals; Butyrophenones; Cytokines; Histamine H1 Antagonists; Humans; Macrophages; Piperidines; T-Lymphocytes

2003
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.
    Current medical research and opinion, 2004, Volume: 20, Issue:1

    Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine

2004
A review of the second-generation antihistamine ebastine for the treatment of allergic disorders.
    Expert opinion on pharmacotherapy, 2004, Volume: 5, Issue:8

    Topics: Anti-Allergic Agents; Asthma; Butyrophenones; Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria

2004
Meta-analysis of the efficacy of ebastine 20 mg compared to loratadine 10 mg and placebo in the symptomatic treatment of seasonal allergic rhinitis.
    International archives of allergy and immunology, 2005, Volume: 138, Issue:4

    Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Multicenter Studies as Topic; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal

2005
Ebastine in allergic rhinitis and chronic idiopathic urticaria.
    Allergy, 2008, Volume: 63 Suppl 89

    Topics: Animals; Butyrophenones; Chronic Disease; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria

2008
New therapies for allergic rhinitis.
    Current allergy and asthma reports, 2014, Volume: 14, Issue:4

    Topics: Administration, Intranasal; Androstadienes; Anti-Allergic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Benzimidazoles; Butyrophenones; Cyproheptadine; Fluticasone; Histamine H1 Antagonists; Humans; Omalizumab; Phthalazines; Piperidines; Pregnenediones; Rhinitis, Allergic; Rhinitis, Allergic, Perennial

2014
Dietary and pharmacological treatment of abdominal pain in IBS.
    Gut, 2017, Volume: 66, Issue:5

    Topics: Abdominal Pain; Anti-Infective Agents; Antidepressive Agents; Butyrophenones; Dipeptides; GABA Agents; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Imidazoles; Irritable Bowel Syndrome; Mentha piperita; Parasympatholytics; Phenylalanine; Piperidines; Plant Oils; Probiotics; Quaternary Ammonium Compounds; Rifamycins; Rifaximin; Serotonin 5-HT3 Receptor Antagonists; Thiophenes; Visceral Pain

2017
A Critical Review of Physicochemical Properties and Analytical Methods Applied to Quantitative Determination of Ebastine.
    Critical reviews in analytical chemistry, 2018, Mar-04, Volume: 48, Issue:2

    Topics: Butyrophenones; Chemistry, Physical; Humans; Molecular Structure; Piperidines

2018
Ebastine in the Treatment of Allergic Rhinitis and Urticaria: 30 Years of Clinical Studies and Real-World Experience.
    Journal of investigational allergology & clinical immunology, 2020, Volume: 30, Issue:3

    Topics: Administration, Oral; Butyrophenones; Histamine; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic; Treatment Outcome; Urticaria

2020
PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19.
    Frontiers in immunology, 2020, Volume: 11

    Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Antirheumatic Agents; Antiviral Agents; Betacoronavirus; Butyrophenones; Class I Phosphatidylinositol 3-Kinases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Humans; Inflammation; Interleukin-6; Molecular Targeted Therapy; Pandemics; Peptidyl-Dipeptidase A; Piperidines; Pneumonia, Viral; Purines; Quinazolinones; SARS-CoV-2

2020

Trials

63 trial(s) available for ebastine and piperidines

ArticleYear
Placebo controlled comparison of acute effects of ebastine and clemastine on performance and EEG.
    European journal of clinical pharmacology, 1992, Volume: 42, Issue:1

    Topics: Adult; Butyrophenones; Clemastine; Cognition; Double-Blind Method; Electroencephalography; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance; Reference Values; Sleep; Surveys and Questionnaires; Wakefulness

1992
Lack of pharmacodynamic and pharmacokinetic interactions of the antihistamine ebastine with ethanol in healthy subjects.
    European journal of clinical pharmacology, 1992, Volume: 43, Issue:2

    Topics: Adult; Butyrophenones; Double-Blind Method; Drug Interactions; Ethanol; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance

1992
Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine.
    Dermatologica, 1991, Volume: 183, Issue:3

    Topics: Administration, Cutaneous; Administration, Oral; Adult; Butyrophenones; Capsules; Cetirizine; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity; Male; Multivariate Analysis; Piperidines; Placebos; Skin; Skin Tests; Time Factors

1991
Ebastine in perennial allergic rhinitis.
    Annals of allergy, 1991, Volume: 67, Issue:6

    Topics: Adult; Butyrophenones; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial; Time Factors

1991
Dose-response relationship of the H1-histamine antagonist, ebastine, against histamine and methacholine-induced bronchoconstriction in patients with asthma.
    Agents and actions, 1990, Volume: 30, Issue:1-2

    Topics: Adult; Asthma; Bronchi; Butyrophenones; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Compounds; Middle Aged; Piperidines

1990
A double-blind placebo-controlled study of the efficacy and tolerability of ebastine against hayfever in general practice patients.
    Journal of internal medicine, 1989, Volume: 226, Issue:6

    Topics: Adult; Butyrophenones; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Seasonal

1989
The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.
    British journal of clinical pharmacology, 1988, Volume: 26, Issue:5

    Topics: Adult; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Male; Piperidines; Time Factors

1988
Ebastine: the effect of a new antihistamine on psychomotor performance and autonomic responses in healthy subjects.
    British journal of clinical pharmacology, 1988, Volume: 26, Issue:5

    Topics: Adult; Autonomic Nervous System; Blood Pressure; Butyrophenones; Flicker Fusion; Heart Rate; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Male; Piperidines; Psychomotor Performance; Reaction Time; Salivation; Surveys and Questionnaires; Time Factors

1988
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94.
    Allergy, 1995, Volume: 50, Issue:3

    Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine

1995
Suppression of the skin reaction to histamine by ebastine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1995, Volume: 74, Issue:5

    Topics: Adult; Anaphylaxis; Butyrophenones; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Skin Tests

1995
Assessment of the wheal size and skin blood flow of the erythema induced by histamine and its modification with cetirizine and ebastine: a crossover, double-blind study.
    Dermatology (Basel, Switzerland), 1994, Volume: 188, Issue:2

    Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Double-Blind Method; Erythema; Female; Histamine; Histamine H1 Antagonists; Humans; Laser-Doppler Flowmetry; Male; Piperidines; Prospective Studies; Regional Blood Flow; Skin

1994
Pharmacokinetics and pharmacodynamics of ebastine in children.
    The Journal of pediatrics, 1993, Volume: 122, Issue:4

    Topics: Butyrophenones; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial; Skin Tests

1993
Diazepam effects on the performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine.
    British journal of clinical pharmacology, 1993, Volume: 35, Issue:3

    Topics: Administration, Oral; Adult; Analysis of Variance; Butyrophenones; Chromatography, High Pressure Liquid; Diazepam; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance

1993
Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.
    British journal of clinical pharmacology, 1993, Volume: 35, Issue:6

    Topics: Adult; Blood Pressure; Butyrophenones; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines

1993
Acute and subchronic effects of the H1-histamine receptor antagonist ebastine in 10, 20 and 30 mg dose, and triprolidine 10 mg on car driving performance.
    British journal of clinical pharmacology, 1993, Volume: 36, Issue:1

    Topics: Adult; Automobile Driving; Butyrophenones; Double-Blind Method; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance; Triprolidine

1993
Comparison of ebastine to cetirizine in seasonal allergic rhinitis in adults.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:6

    Topics: Adult; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Seasonal

1996
Clinical studies of the efficacy and tolerability of ebastine 10 or 20 mg once daily in the treatment of seasonal allergic rhinitis in the US.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Adolescent; Adult; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; United States

1996
Comparison of the efficacy of ebastine 10mg and 20mg once daily with that of cetirizine 10mg once daily in adults with seasonal allergic rhinitis. A multicentre double-blind study.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal

1996
Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Adult; Anti-Allergic Agents; Butyrophenones; Chronic Disease; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine; Urticaria

1996
Clinical efficacy of ebastine in the treatment and prevention of seasonal allergic rhinitis.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Astemizole; Butyrophenones; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Seasons

1996
Comparison of azelastine nasal spray and oral ebastine in treating seasonal allergic rhinitis.
    Current medical research and opinion, 1995, Volume: 13, Issue:6

    Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Phthalazines; Piperidines; Rhinitis, Allergic, Seasonal; Treatment Outcome

1995
Overview of allergic mechanisms. Ebastine has more than an antihistamine effect.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Adolescent; Adult; Allergens; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine H1 Antagonists; Humans; Leukotriene C4; Male; Middle Aged; Nasal Polyps; Piperidines; Pollen; Prostaglandin D2; Rhinitis, Allergic, Seasonal

1996
[Ebastine : treatment of perennial rhinitis in the child].
    Allergie et immunologie, 1996, Volume: 28, Issue:8

    Topics: Adolescent; Butyrophenones; Carbachol; Child; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists; Humans; Male; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Perennial; Skin Tests; Treatment Outcome

1996
Effect of ebastine on mosquito bites.
    Acta dermato-venereologica, 1997, Volume: 77, Issue:4

    Topics: Adult; Aedes; Animals; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Insect Bites and Stings; Male; Middle Aged; Piperidines; Premedication

1997
Consistency of the efficacy of cetirizine and ebastine on skin reactivity.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 80, Issue:1

    Topics: Adult; Anaphylaxis; Butyrophenones; Cetirizine; Cross-Over Studies; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Piperidines; Safety; Skin; Skin Tests

1998
Comparison of efficacy and safety of cetirizine and ebastine in patients with perennial allergic rhinitis.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1998, Volume: 80, Issue:5

    Topics: Adolescent; Adult; Aged; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial

1998
Comparison of the effects of cetirizine and ebastine on the skin response to histamine iontophoresis monitored with laser Doppler flowmetry.
    Dermatology (Basel, Switzerland), 1998, Volume: 197, Issue:2

    Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; Laser-Doppler Flowmetry; Male; Piperidines; Skin; Skin Diseases; Skin Tests; Time Factors

1998
Pharmacokinetics and electrocardiographic effect of ebastine in young versus elderly healthy subjects.
    American journal of therapeutics, 1998, Volume: 5, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Butyrophenones; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Monitoring; Electrocardiography; Electrocardiography, Ambulatory; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines

1998
A 12-week, placebo-controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in the treatment of perennial allergic rhinitis. Multicentre Study Group.
    Allergy, 1999, Volume: 54, Issue:6

    Topics: Adolescent; Adult; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial; Treatment Outcome

1999
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects.
    Allergy, 1999, Volume: 54, Issue:7

    Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria

1999
Consistency and efficacy of cetirizine (10 mg) versus ebastine (20 mg) at 4 h on skin reactivity.
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:8

    Topics: Adolescent; Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Skin Tests

1999
Comparative clinical studies with ebastine: efficacy and tolerability.
    Drug safety, 1999, Volume: 21 Suppl 1

    Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Electrocardiography; Electrocardiography, Ambulatory; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

1999
Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis. The Ebastine Study Group.
    The Journal of allergy and clinical immunology, 2000, Volume: 105, Issue:6 Pt 1

    Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal

2000
Problems of heart rate correction in assessment of drug-induced QT interval prolongation.
    Journal of cardiovascular electrophysiology, 2001, Volume: 12, Issue:4

    Topics: Butyrophenones; Cross-Over Studies; Drug Evaluation; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Long QT Syndrome; Models, Cardiovascular; Piperidines; Regression Analysis

2001
Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.
    International journal of clinical pharmacology and therapeutics, 2001, Volume: 39, Issue:3

    Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Area Under Curve; Butyrophenones; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Mass Spectrometry; Middle Aged; Piperidines; Sex Factors

2001
Duration of the antihistaminic effect after discontinuation of ebastine.
    Allergy, 2001, Volume: 56, Issue:6

    Topics: Adolescent; Adult; Butyrophenones; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Time and Motion Studies; Time Factors

2001
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval.
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:2

    Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines; Terfenadine

2001
Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.
    British journal of clinical pharmacology, 2001, Volume: 52, Issue:5

    Topics: Adult; Butyrophenones; Carbon Radioisotopes; Cerebral Cortex; Chlorpheniramine; Cross-Over Studies; Histamine H1 Antagonists; Humans; Male; Models, Biological; Piperidines; Receptors, Histamine H1; Single-Blind Method; Thalamus; Tomography, Emission-Computed; Treatment Outcome

2001
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 88, Issue:2

    Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria

2002
Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration.
    British journal of clinical pharmacology, 2002, Volume: 53, Issue:3

    Topics: Administration, Oral; Adult; Butyrophenones; Chlorpheniramine; Cognition; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Male; Piperidines; Reaction Time; Sleep; Stereoisomerism; Visual Perception

2002
The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers.
    Current medical research and opinion, 2001, Volume: 17, Issue:4

    Topics: Adult; Analysis of Variance; Butyrophenones; Cognition; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Piperidines; Psychomotor Performance; Triprolidine

2001
[Clinical efficacy of Ebastine under placebo-controlled outdoors clinical study on cedar pollinosis].
    Arerugi = [Allergy], 2002, Volume: 51, Issue:4

    Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Single-Blind Method

2002
Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy.
    Allergy, 2002, Volume: 57, Issue:6

    Topics: Adult; Animals; Butyrophenones; Cetirizine; Conscious Sedation; Cross-Over Studies; Culicidae; Double-Blind Method; Finland; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Insect Bites and Stings; Loratadine; Middle Aged; Piperidines; Pruritus; Severity of Illness Index; Time Factors; Treatment Outcome

2002
Efficacy of ebastine, cetirizine, and loratadine in histamine cutaneous challenges.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2002, Volume: 89, Issue:3

    Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Male; Middle Aged; Piperidines; Skin Tests

2002
A double-blind, placebo-controlled study of the efficacy and safety of ebastine 20 mg once daily given with and without food in the treatment of seasonal allergic rhinitis.
    Journal of clinical pharmacology, 2002, Volume: 42, Issue:10

    Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome

2002
Efficacy of ebastine in the control of nasal congestion associated with allergic rhinitis.
    Methods and findings in experimental and clinical pharmacology, 2003, Volume: 25, Issue:2

    Topics: Adult; Ambrosia; Butyrophenones; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Obstruction; Piperidines; Rhinitis, Allergic, Seasonal

2003
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.
    Drugs under experimental and clinical research, 2002, Volume: 28, Issue:6

    Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine

2002
Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial.
    Allergy, 2003, Volume: 58, Issue:8

    Topics: Administration, Intranasal; Administration, Oral; Adult; Anti-Allergic Agents; Butyrophenones; Conjunctivitis, Allergic; Female; Glucocorticoids; Guideline Adherence; Histamine H1 Antagonists; Humans; Male; Nedocromil; Piperidines; Practice Guidelines as Topic; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Triamcinolone Acetonide

2003
A study comparing the inhibitory effects of single and repeated oral doses of ebastine and fexofenadine against histamine-induced skin reactivity.
    International archives of allergy and immunology, 2003, Volume: 132, Issue:3

    Topics: Administration, Oral; Adolescent; Adult; Butyrophenones; Double-Blind Method; Female; Histamine Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Terfenadine

2003
Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers: a phase I open-label study.
    Clinical pharmacokinetics, 2004, Volume: 43, Issue:2

    Topics: Adult; Area Under Curve; Butyrophenones; Case-Control Studies; Female; Half-Life; Histamine H1 Antagonists; Humans; Intestinal Absorption; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Piperidines

2004
Efficacy and safety of ebastine 20 mg compared to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled study.
    International archives of allergy and immunology, 2004, Volume: 133, Issue:4

    Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Least-Squares Analysis; Loratadine; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal

2004
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of ebastine (20 mg and 10 mg) to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis.
    Journal of investigational allergology & clinical immunology, 2004, Volume: 14, Issue:1

    Topics: Administration, Oral; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Loratadine; Male; Multivariate Analysis; Patch Tests; Piperidines; Probability; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome

2004
Rupatadine 10 mg and ebastine 10 mg in seasonal allergic rhinitis: a comparison study.
    Allergy, 2004, Volume: 59, Issue:7

    Topics: Adolescent; Adult; Analysis of Variance; Anti-Allergic Agents; Butyrophenones; Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome

2004
Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects.
    British journal of clinical pharmacology, 2005, Volume: 59, Issue:3

    Topics: Adolescent; Adult; Antifungal Agents; Butyrophenones; Double-Blind Method; Drug Combinations; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Ketoconazole; Loratadine; Male; Piperidines

2005
A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults.
    Clinical drug investigation, 2007, Volume: 27, Issue:7

    Topics: Adult; Butyrophenones; Chemistry, Pharmaceutical; Dermatitis, Contact; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Patient Acceptance of Health Care; Piperidines; Skin; Tablets; Treatment Outcome

2007
[New generation antihistamines as monotherapy or in combination. What is the relevance for daily clinical routine for allergic rhinoconjunctivitis].
    HNO, 2007, Volume: 55, Issue:6

    Topics: Adrenal Cortex Hormones; Adult; Butyrophenones; Conjunctivitis; Drug Combinations; Female; Germany; Histamine H1 Antagonists; Humans; Male; Piperidines; Practice Patterns, Physicians'; Prevalence; Rhinitis, Allergic, Seasonal; Treatment Outcome

2007
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
    Clinical therapeutics, 2007, Volume: 29, Issue:5

    Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Piperidines; Pruritus; Skin; Skin Tests

2007
Acquired cold urticaria symptoms can be safely prevented by ebastine.
    Allergy, 2007, Volume: 62, Issue:12

    Topics: Adult; Affect; Butyrophenones; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Psychometrics; Treatment Outcome; Urticaria

2007
Prevention of signs and symptoms of dermographic urticaria by single-dose ebastine 20 mg.
    Clinical and experimental dermatology, 2009, Volume: 34, Issue:5

    Topics: Adult; Affect; Aged; Butyrophenones; Cognition; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Physical Stimulation; Pilot Projects; Piperidines; Psychometrics; Treatment Outcome; Urticaria

2009
Implementation of guidelines for allergic rhinitis in specialist practices. A randomized pragmatic controlled trial.
    International archives of allergy and immunology, 2009, Volume: 150, Issue:1

    Topics: Adolescent; Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Practice Guidelines as Topic; Practice Patterns, Physicians'; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Young Adult

2009
Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants.
    Journal of clinical pharmacology, 2010, Volume: 50, Issue:2

    Topics: Adult; Antifungal Agents; Butyrophenones; Cross-Over Studies; Drug Interactions; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Itraconazole; Male; Piperidines; Rifampin; Skin; Young Adult

2010
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.
    Gastroenterology, 2016, Volume: 150, Issue:4

    Topics: Abdominal Pain; Adolescent; Adult; Aged; Analgesics; Belgium; Biopsy; Butyrophenones; Calcium Signaling; Double-Blind Method; Female; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Neurons; Pain Measurement; Pain Threshold; Piperidines; Quality of Life; Receptor Cross-Talk; Receptors, Histamine H1; Rectum; Remission Induction; Surveys and Questionnaires; Time Factors; Treatment Outcome; TRPV Cation Channels; Young Adult

2016
[Effects of double-dose antihistamine or combined therapy in allergic rhinitis].
    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery, 2018, Jan-05, Volume: 32, Issue:1

    Topics: Administration, Intranasal; Anti-Allergic Agents; Butyrophenones; Double-Blind Method; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Mometasone Furoate; Piperidines; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal

2018

Other Studies

96 other study(ies) available for ebastine and piperidines

ArticleYear
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1994, Volume: 103, Issue:3

    Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Male; Phenothiazines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Terfenadine

1994
Optically active analogues of ebastine: synthesis and effect of chirality on their antihistaminic and antimuscarinic activity.
    Chirality, 1994, Volume: 6, Issue:8

    Topics: Animals; Butyrophenones; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Models, Molecular; Muscarinic Antagonists; Piperidines; Receptors, Histamine H1; Receptors, Muscarinic; Stereoisomerism

1994
Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:1

    Topics: Administration, Oral; Animals; Butyrophenones; Dogs; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Macaca fascicularis; Male; Piperidines; Protein Binding; Rats; Rats, Wistar; Species Specificity

1994
Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:1

    Topics: Adult; Butyrophenones; Food; Half-Life; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Protein Binding

1994
Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:4

    Topics: Administration, Oral; Animals; Autoradiography; Bile; Blood Proteins; Butyrophenones; Chromatography, Thin Layer; Feces; Female; Half-Life; Histamine H1 Antagonists; Humans; Injections, Intravenous; Intestinal Absorption; Male; Milk; Piperidines; Pregnancy; Protein Binding; Rats; Rats, Wistar; Tissue Distribution

1994
Absorption, distribution, metabolism and excretion of [14C]ebastine after repeated oral administration in rats.
    Arzneimittel-Forschung, 1994, Volume: 44, Issue:4

    Topics: Administration, Oral; Animals; Autoradiography; Behavior, Animal; Biotransformation; Butyrophenones; Chromatography, Thin Layer; Eating; Histamine H1 Antagonists; Intestinal Absorption; Male; Piperidines; Rats; Rats, Wistar; Tissue Distribution; Weight Gain

1994
Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry.
    Biological mass spectrometry, 1994, Volume: 23, Issue:7

    Topics: Animals; Biotransformation; Butyrophenones; Chromatography, Thin Layer; Feces; Histamine H1 Antagonists; Hydrolysis; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Oxidation-Reduction; Piperidines; Rats; Rats, Wistar; Sulfates

1994
Spectrophotometric determination of pharmaceutical dosages by partial least-squares calibration.
    Journal of pharmaceutical and biomedical analysis, 1994, Volume: 12, Issue:4

    Topics: Butyrophenones; Excipients; Histamine H1 Antagonists; Indicators and Reagents; Least-Squares Analysis; Nephelometry and Turbidimetry; Parabens; Piperidines; Spectrophotometry, Ultraviolet

1994
Pharmacokinetic and pharmacodynamic studies of the histamine H1-receptor antagonist ebastine in dogs.
    The Journal of pharmacy and pharmacology, 1994, Volume: 46, Issue:7

    Topics: Administration, Oral; Analysis of Variance; Animals; Biological Availability; Butyrophenones; Chromatography, High Pressure Liquid; Dogs; Half-Life; Histamine H1 Antagonists; Injections, Intradermal; Male; Piperidines; Skin

1994
A steric approach for the design of antihistamines with low muscarinic receptor antagonism.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1995, Volume: 44 Suppl 1

    Topics: Animals; Butyrophenones; Drug Design; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Molecular Structure; Muscarinic Antagonists; Piperidines; Stereoisomerism; Structure-Activity Relationship

1995
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5

    Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine

1996
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:2

    Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Ketoconazole; Liver; Male; Mixed Function Oxygenases; Piperidines; Terfenadine; Torsades de Pointes

1996
Microbial oxidation of ebastine.
    Applied microbiology and biotechnology, 1996, Volume: 44, Issue:6

    Topics: Biotransformation; Butyrophenones; Histamine H1 Antagonists; Mucorales; Oxidation-Reduction; Piperidines

1996
Parametrization by nonlinear regression analysis of the active acid metabolite of ebastine using different weighting methods.
    International journal of clinical pharmacology and therapeutics, 1996, Volume: 34, Issue:12

    Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Butyrophenones; Half-Life; Histamine H1 Antagonists; Humans; Male; Metabolic Clearance Rate; Piperidines; Regression Analysis

1996
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
    Inflammation research : official journal of the European Histamine Research Society ... [et al.], 1997, Volume: 46 Suppl 1

    Topics: Animals; Butyrophenones; Cell Membrane; Chromones; Cyproheptadine; Guinea Pigs; Histamine H1 Antagonists; Ileum; Leukotriene Antagonists; Leukotriene D4; Lung; Membrane Proteins; Muscle Contraction; Phthalazines; Piperidines; Receptors, Leukotriene

1997
Suppression of mammalian K+ channel family by ebastine.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 281, Issue:1

    Topics: Animals; Butyrophenones; Electrocardiography; Guinea Pigs; Heart; Histamine H1 Antagonists; Male; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Xenopus laevis

1997
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:8

    Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes

1996
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines.
    Arzneimittel-Forschung, 1996, Volume: 46, Issue:8

    Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes

1996
Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels.
    European journal of pharmacology, 1997, May-20, Volume: 326, Issue:2-3

    Topics: Animals; Butyrophenones; Cells, Cultured; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Terfenadine

1997
Studies on the first-pass metabolism of ebastine in rats.
    Arzneimittel-Forschung, 1997, Volume: 47, Issue:8

    Topics: Animals; Biological Availability; Biotransformation; Butyrophenones; Chromatography, Thin Layer; Femoral Vein; Half-Life; Histamine H1 Antagonists; Infusions, Intravenous; Intestinal Absorption; Intestine, Small; Liver; Male; Piperidines; Portal Vein; Rats; Rats, Wistar

1997
Comparison of ebastine with cetirizine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1997, Volume: 79, Issue:5

    Topics: Adult; Butyrophenones; Cetirizine; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal

1997
[The diagnosis and drug therapy of allergic dermatoses].
    Terapevticheskii arkhiv, 1998, Volume: 70, Issue:3

    Topics: Butyrophenones; Dermatitis, Allergic Contact; Drug Evaluation; Histamine H1 Antagonists; Humans; Moscow; Piperidines; Prevalence

1998
N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450.
    Drug metabolism and disposition: the biological fate of chemicals, 1998, Volume: 26, Issue:6

    Topics: Butyrophenones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Histamine H1 Antagonists; Humans; Hydroxylation; Microsomes, Liver; Piperidines

1998
Blood-brain barrier permeation: molecular parameters governing passive diffusion.
    The Journal of membrane biology, 1998, Oct-01, Volume: 165, Issue:3

    Topics: Air; Amiodarone; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Butyrophenones; Diffusion; Domperidone; Histamine H1 Antagonists; Humans; Kinetics; Loperamide; Micelles; Models, Biological; Piperidines; Surface Properties; Thermodynamics; Water

1998
[Ebastine in the treatment of seasonal allergic rhinitis].
    Terapevticheskii arkhiv, 1998, Volume: 70, Issue:9

    Topics: Administration, Oral; Adolescent; Adult; Aged; Butyrophenones; Child; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Treatment Outcome

1998
Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats.
    Biopharmaceutics & drug disposition, 1999, Volume: 20, Issue:2

    Topics: Animals; Arrhythmias, Cardiac; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Male; Piperidines; Rats; Rats, Sprague-Dawley; Terfenadine

1999
Cardiotoxicity of second-generation antihistamines.
    Drugs, 1999, Volume: 57, Issue:6

    Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine

1999
Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes.
    The Journal of pharmacy and pharmacology, 1999, Volume: 51, Issue:9

    Topics: Animals; Butyrophenones; Dibenzazepines; Electrophysiology; Heart Ventricles; Histamine H1 Antagonists; Imidazoles; Male; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley; Terfenadine

1999
Computer-assisted comparison of the structural and electronic dispositions of ebastine and terfenadine.
    Drug safety, 1999, Volume: 21 Suppl 1

    Topics: Butyrophenones; Histamine H1 Antagonists; Models, Molecular; Molecular Conformation; Piperidines; Signal Processing, Computer-Assisted; Terfenadine

1999
cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine.
    Biochemical and biophysical research communications, 2001, Feb-02, Volume: 280, Issue:4

    Topics: Amino Acid Sequence; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Base Sequence; Butyrophenones; Catalysis; Cloning, Molecular; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; DNA, Complementary; Gene Library; Humans; Intestine, Small; Leukotriene B4; Liver; Mixed Function Oxygenases; Molecular Sequence Data; Piperidines; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Sequence Analysis, DNA; Sequence Homology, Amino Acid

2001
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition.
    Nature immunology, 2001, Volume: 2, Issue:2

    Topics: Animals; Antigens; Azepines; Benzoquinones; Bronchoconstriction; Butyrophenones; Eicosapentaenoic Acid; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Indomethacin; Male; Methacholine Chloride; Phospholipases A; Phospholipases A2; Piperidines; Respiratory Hypersensitivity; Triazoles

2001
Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine.
    Journal of drug targeting, 2000, Volume: 8, Issue:6

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Butyrophenones; Cattle; Endothelium, Vascular; Histamine H1 Antagonists; Humans; Male; Mice; Mice, Mutant Strains; Piperidines; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured

2000
A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.
    Drug metabolism and disposition: the biological fate of chemicals, 2001, Volume: 29, Issue:6

    Topics: Amino Acid Sequence; Animals; Butyrophenones; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Histamine H1 Antagonists; Hydroxylation; Intestine, Small; Macaca fascicularis; Male; Microsomes; Molecular Sequence Data; Piperidines; Sequence Homology, Amino Acid

2001
Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography.
    Journal of chromatography. B, Biomedical sciences and applications, 2001, Jun-05, Volume: 757, Issue:1

    Topics: Butyrophenones; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Piperidines; Reproducibility of Results; Sensitivity and Specificity

2001
Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers.
    Biological & pharmaceutical bulletin, 2001, Volume: 24, Issue:8

    Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Butyrophenones; Caco-2 Cells; Cyclosporine; Histamine H1 Antagonists; Humans; Immunosuppressive Agents; Piperidines

2001
Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.
    The Journal of pharmacology and experimental therapeutics, 2002, Volume: 300, Issue:1

    Topics: Antibodies, Blocking; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Butyrophenones; Cloning, Molecular; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; In Vitro Techniques; Intestinal Mucosa; Intestines; Kinetics; Leukotriene B4; Microsomes; Mixed Function Oxygenases; Oxygenases; Piperidines; Recombinant Proteins

2002
Preclinical comparison of ebastine and other second generation H1-antihistamines.
    Pharmacology & toxicology, 2001, Volume: 89, Issue:4

    Topics: Animals; Butyrophenones; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Histamine H1 Antagonists; Intracellular Membranes; Male; Passive Cutaneous Anaphylaxis; Piperidines; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H1; Skin

2001
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations].
    Terapevticheskii arkhiv, 2002, Volume: 74, Issue:3

    Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine

2002
Anaphylactoid reaction caused by moxifloxacin.
    Journal of investigational allergology & clinical immunology, 2002, Volume: 12, Issue:1

    Topics: Adult; Anaphylaxis; Anti-Infective Agents; Aza Compounds; Butyrophenones; Female; Fluoroquinolones; Humans; Moxifloxacin; Otitis; Piperidines; Quinolines

2002
[Antihistamines. How safe are they?].
    MMW Fortschritte der Medizin, 2002, Sep-12, Volume: 144, Issue:37

    Topics: Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Urticaria

2002
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:11

    Topics: Animals; Antibodies, Blocking; Arachidonic Acid; Astemizole; Blotting, Western; Butyrophenones; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Cloning, Molecular; COS Cells; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; DNA, Complementary; Enzyme Inhibitors; Gene Library; Histamine H1 Antagonists; Humans; In Vitro Techniques; Intestinal Mucosa; Mass Spectrometry; Microsomes, Liver; Oxygenases; Piperidines; Rabbits; Recombinant Proteins

2002
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval.
    British journal of clinical pharmacology, 2002, Volume: 54, Issue:6

    Topics: Butyrophenones; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine

2002
In vivo evidence for a lack of central effect of ebastine, an antihistaminic agent, in rats: a microdialysis study.
    Japanese journal of pharmacology, 2002, Volume: 90, Issue:4

    Topics: Animals; Butyrophenones; Chlorpheniramine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Histamine H1 Antagonists; In Vitro Techniques; Male; Microdialysis; Nomifensine; Piperidines; Rats; Rats, Wistar

2002
Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice.
    Psychopharmacology, 2003, Volume: 166, Issue:2

    Topics: Animals; Antitussive Agents; Butyrophenones; Cetirizine; Codeine; Dopamine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Limbic System; Male; Mice; Mice, Inbred ICR; Piperidines; Receptors, Dopamine D1; Reward

2003
Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models.
    Arzneimittel-Forschung, 2003, Volume: 53, Issue:2

    Topics: Aerosols; Airway Resistance; Algorithms; Animals; Anti-Allergic Agents; Bronchial Spasm; Butyrophenones; Cetirizine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Leukotriene C4; Loratadine; Male; Ovalbumin; Piperidines

2003
[Antihistaminics. Side effects also after raising dosage at the placebo level].
    MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22

    Topics: Anti-Allergic Agents; Benzimidazoles; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Meta-Analysis as Topic; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal

2003
[In seasonal and perennial rhinitis. Superiority to standard H1 blockers].
    MMW Fortschritte der Medizin, 2003, May-29, Volume: 145, Issue:22

    Topics: Anti-Allergic Agents; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Time Factors

2003
Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.
    Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 2003, Volume: 33, Issue:11

    Topics: Antigens, CD; Butyrophenones; Cell Division; Cell Movement; Cells, Cultured; Cytokines; Dose-Response Relationship, Immunologic; Endothelium; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Lymphocyte Activation; Macrophages; Piperidines; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells

2003
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.
    Bioorganic & medicinal chemistry letters, 2004, Nov-01, Volume: 14, Issue:21

    Topics: Absidia; Biotransformation; Butyrophenones; Cunninghamella; Histamine H1 Antagonists; Oxidation-Reduction; Piperidines; Streptomyces griseus; Terfenadine

2004
Simultaneous determination of ebastine and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2004, Dec-25, Volume: 813, Issue:1-2

    Topics: Butyrophenones; Chromatography, Liquid; Histamine H1 Antagonists; Humans; Mass Spectrometry; Piperidines; Sensitivity and Specificity

2004
Safety of ebastine.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:3

    Topics: Arrhythmias, Cardiac; Butyrophenones; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis; Treatment Outcome; Urticaria

2005
Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 2005, Volume: 94, Issue:3

    Topics: Animals; Arrhythmias, Cardiac; Automobile Driving; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Humans; Models, Animal; Piperidines; Potassium Channels; Time Factors

2005
Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity.
    Pharmacogenetics and genomics, 2005, Volume: 15, Issue:2

    Topics: Alleles; Animals; Astemizole; Butyrophenones; Catalysis; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA Primers; Dose-Response Relationship, Drug; Gene Frequency; Genetic Variation; Heterozygote; Histamine H1 Antagonists; Humans; Insecta; Kinetics; Korea; Methylation; Models, Molecular; Mutation; Oxygenases; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Recombinant Proteins; Recombination, Genetic; Sequence Analysis, DNA; Time Factors

2005
[Cardiac arrest following treatment with non-cardiologic QT-interval-increasing medications].
    Ugeskrift for laeger, 2005, May-02, Volume: 167, Issue:18

    Topics: Bendroflumethiazide; Butyrophenones; Cisapride; Diuretics; Electrocardiography; Female; Furosemide; Gastrointestinal Agents; Heart Arrest; Histamine H1 Antagonists; Humans; Middle Aged; Piperidines; Potassium Chloride; Sodium Chloride Symporter Inhibitors; Torsades de Pointes

2005
The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study.
    British journal of clinical pharmacology, 2006, Volume: 62, Issue:2

    Topics: Administration, Oral; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Body Weight; Butyrophenones; Citrus paradisi; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Genotype; Histamine H1 Antagonists; Humans; Male; Oxygenases; Pilot Projects; Piperidines; Polymorphism, Restriction Fragment Length; Sex Factors

2006
Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
    Drug metabolism and disposition: the biological fate of chemicals, 2006, Volume: 34, Issue:11

    Topics: Butyrophenones; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Microsomes, Liver; Oxygenases; Piperidines

2006
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.
    European annals of allergy and clinical immunology, 2006, Volume: 38, Issue:10

    Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunctivitis, Allergic; Cromolyn Sodium; Diabetes Mellitus, Type 1; Heart; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Piperazines; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine

2006
Palmoplantar pityriasis rosea: two case reports.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2007, Volume: 21, Issue:3

    Topics: Adrenal Cortex Hormones; Adult; Butyrophenones; Diagnosis, Differential; Female; Foot Dermatoses; Hand Dermatoses; Histamine H1 Antagonists; Humans; Piperidines; Pityriasis Rosea

2007
Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment.
    Clinical pharmacokinetics, 2007, Volume: 46, Issue:6

    Topics: Administration, Oral; Adult; Aged; Area Under Curve; Butyrophenones; Drug Administration Schedule; Drug Monitoring; Electrocardiography; Female; Half-Life; Histamine H1 Antagonists; Humans; Kidney Function Tests; Male; Middle Aged; Piperidines; Renal Insufficiency

2007
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
    Drug metabolism and disposition: the biological fate of chemicals, 2007, Volume: 35, Issue:11

    Topics: Amidines; Antibodies; Antiparasitic Agents; Arachidonic Acid; Benzamidines; Benzoflavones; Butyrophenones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Intestinal Mucosa; Intestines; Kinetics; Methylation; Microsomes; Oxygenases; Piperidines; Prodrugs; Recombinant Proteins; Stereoisomerism

2007
[Ebastine (kestine 20) in therapy of allergic rhinitis].
    Vestnik otorinolaringologii, 2007, Issue:3

    Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial

2007
[Ebastine-induced hepatotoxicity].
    Gastroenterologia y hepatologia, 2007, Volume: 30, Issue:8

    Topics: Butyrophenones; Chemical and Drug Induced Liver Injury; Female; Histamine H1 Antagonists; Humans; Middle Aged; Piperidines

2007
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
    Proteins, 2008, May-01, Volume: 71, Issue:2

    Topics: Amino Acid Sequence; Binding Sites; Butyrophenones; Computer Simulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Oxygenases; Piperidines; Protein Interaction Domains and Motifs; Sequence Alignment; Structural Homology, Protein; Substrate Specificity; Terfenadine

2008
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet [20 mg] versus desloratadine capsule [5 mg]: a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
    Clinical therapeutics, 2007, Volume: 29, Issue:12

    Topics: Butyrophenones; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Skin Tests

2007
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.
    Methods and findings in experimental and clinical pharmacology, 2008, Volume: 30, Issue:3

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria

2008
Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction.
    Journal of investigational allergology & clinical immunology, 2008, Volume: 18, Issue:4

    Topics: Aged; Anaphylaxis; Butyrophenones; Chlorpheniramine; Desensitization, Immunologic; Drug Hypersensitivity; Female; Ferrous Compounds; Histamine H1 Antagonists; Humans; Lactates; Piperidines

2008
[Avene-50 and Ebastine in treatment and prevention of photodermatosis].
    Georgian medical news, 2009, Issue:167

    Topics: Adolescent; Adult; Aged; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Mineral Waters; Photosensitivity Disorders; Piperidines; Sunscreening Agents; Young Adult

2009
Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata.
    Journal of dermatological science, 2010, Volume: 58, Issue:2

    Topics: Adult; Alopecia Areata; Animals; Butyrophenones; Disease Models, Animal; Female; Histamine Antagonists; Humans; Immunotherapy; Mice; Mice, Inbred C3H; Piperidines; Remission Induction; Treatment Outcome

2010
Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.
    European journal of pharmacology, 2011, Jan-10, Volume: 650, Issue:1

    Topics: Animals; Butyrophenones; Drug Administration Schedule; Female; Follow-Up Studies; Food; Histamine; Histamine H1 Antagonists; Infusion Pumps; Injections; Motivation; Nicotine; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Self Administration; Tobacco Use Disorder

2011
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.
    Journal of medicinal chemistry, 2011, Mar-24, Volume: 54, Issue:6

    Topics: Animals; Aripiprazole; ATP Binding Cassette Transporter, Subfamily B, Member 1; Butyrophenones; Cell Line, Tumor; Cell Membrane Permeability; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Models, Molecular; Molecular Structure; Piperazines; Piperidines; Protein Binding; Quantitative Structure-Activity Relationship; Quinolones

2011
Urticaria due to antihistamines.
    Journal of investigational allergology & clinical immunology, 2011, Volume: 21, Issue:1

    Topics: Administration, Oral; Butyrophenones; Diagnosis, Differential; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Piperidines; Terfenadine; Urticaria

2011
Myocardial pharmacokinetics of ebastine, a substrate for cytochrome P450 2J, in rat isolated heart.
    British journal of pharmacology, 2011, Volume: 163, Issue:8

    Topics: Animals; Butyrophenones; Cytochrome P-450 Enzyme System; Heart; Histamine H1 Antagonists; In Vitro Techniques; Male; Models, Chemical; Myocardium; Piperidines; Rats; Rats, Wistar

2011
Maxillary sinus hypoplasia with a patent ostiomeatal complex: A therapeutic dilemma.
    Auris, nasus, larynx, 2012, Volume: 39, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Butyrophenones; Clarithromycin; Cohort Studies; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Male; Maxillary Sinus; Maxillary Sinusitis; Middle Aged; Nasal Mucosa; Piperidines; Tomography, X-Ray Computed; Young Adult

2012
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen.
    Acta oto-laryngologica, 2012, Volume: 132, Issue:4

    Topics: Butyrophenones; Cryptomeria; Female; Histamine Antagonists; Humans; Interleukin-33; Interleukin-5; Interleukins; Male; Middle Aged; Nasal Mucosa; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine

2012
A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.
    Journal of biomolecular screening, 2012, Volume: 17, Issue:7

    Topics: Anti-Inflammatory Agents; Beclomethasone; Biosensing Techniques; Butyrophenones; Cell Line; Dose-Response Relationship, Drug; Drug Discovery; ErbB Receptors; Flurandrenolone; High-Throughput Screening Assays; Histamine H1 Antagonists; Humans; Permeability; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Reproducibility of Results; Signal-To-Noise Ratio

2012
Using an innovative Quality-by-Design approach for development of a stability indicating UHPLC method for ebastine in the API and pharmaceutical formulations.
    Journal of pharmaceutical and biomedical analysis, 2013, May-05, Volume: 78-79

    Topics: Butyrophenones; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Limit of Detection; Pharmaceutical Preparations; Piperidines; Reproducibility of Results

2013
Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers.
    Protein science : a publication of the Protein Society, 2013, Volume: 22, Issue:7

    Topics: Amino Acid Sequence; Butyrophenones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Escherichia coli; Humans; Hydroxylation; Lipid Bilayers; Models, Molecular; Molecular Sequence Data; Mutation; NADP; Nanostructures; Oxidation-Reduction; Piperidines; Protein Binding; Sequence Alignment

2013
Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists.
    PloS one, 2013, Volume: 8, Issue:6

    Topics: Animals; Blotting, Western; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Irritable Bowel Syndrome; Mast Cells; Maternal Deprivation; Occludin; Piperidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Psychological; Terfenadine

2013
Orthogonal projection to latent structures combined with artificial neural networks in non-destructive analysis of ebastine powder.
    Acta chimica Slovenica, 2014, Volume: 61, Issue:1

    Topics: Butyrophenones; Neural Networks, Computer; Piperidines; Powders; Spectrophotometry, Infrared

2014
Case report of cold-weather-induced radiation recall dermatitis after chemoradiotherapy with cisplatin.
    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al], 2014, Volume: 190, Issue:8

    Topics: Aged; Antineoplastic Agents; Butyrophenones; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Cold Temperature; Drug Therapy, Combination; Female; Humans; Methylprednisolone; Nasopharyngeal Neoplasms; Neoplasm Staging; Piperidines; Radiodermatitis

2014
[Hyposensitizing and antioxidative pharmacotherapy of the cyst-like structures in the maxillary sinuses].
    Vestnik otorinolaringologii, 2014, Issue:4

    Topics: Adolescent; Adult; Antioxidants; Butyrophenones; Cysts; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Male; Maxillary Sinus; Maxillary Sinusitis; Middle Aged; Picolines; Piperidines; Rhinitis, Allergic; Treatment Outcome; Young Adult

2014
A novel UV degradation product of Ebastine: isolation and characterization using Q-TOF, NMR, IR and computational chemistry.
    Journal of pharmaceutical and biomedical analysis, 2015, Mar-25, Volume: 107

    Topics: Butyrophenones; Chromatography, High Pressure Liquid; Mass Spectrometry; Piperidines; Spectroscopy, Fourier Transform Infrared; Ultraviolet Rays

2015
A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine.
    Drug metabolism and disposition: the biological fate of chemicals, 2016, Volume: 44, Issue:6

    Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Butyrophenones; Callithrix; Cytochrome P-450 Enzyme System; Female; Histamine Antagonists; Humans; Hydroxylation; Intestine, Small; Liver; Macaca fascicularis; Male; Microsomes, Liver; Middle Aged; Piperidines; Sequence Alignment; Species Specificity; Substrate Specificity; Young Adult

2016
Simultaneous Liquid Chromatographic Determination of Ebastine with Two Sympathomimetic Drugs Using a Monolithic Column.
    Journal of chromatographic science, 2017, 03-01, Volume: 55, Issue:3

    Topics: Butyrophenones; Chromatography, Reverse-Phase; Limit of Detection; Linear Models; Piperidines; Reproducibility of Results; Sympathomimetics

2017
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.
    Xenobiotica; the fate of foreign compounds in biological systems, 2019, Volume: 49, Issue:2

    Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide

2019
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Mar-15, Volume: 42

    Topics: Antineoplastic Agents, Phytogenic; Astemizole; Butyrophenones; Cell Proliferation; Chalcones; Chromatography, Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Forkhead Box Protein O3; Hep G2 Cells; Humans; Microsomes, Liver; Molecular Docking Simulation; Piperidines; Resorcinols; Tandem Mass Spectrometry

2018
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.
    International journal of molecular sciences, 2018, Jul-16, Volume: 19, Issue:7

    Topics: Arginine; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Humans; Hydrogen Bonding; Hydroxylation; Molecular Docking Simulation; Molecular Structure; Mutation; Piperidines; Protein Conformation; Substrate Specificity

2018
Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation.
    BioMed research international, 2019, Volume: 2019

    Topics: Alopecia; Apoptosis; Butyrophenones; Cell Line; Cell Proliferation; Dermis; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hair; Hair Follicle; Humans; Mitogen-Activated Protein Kinase 3; Piperidines; Proto-Oncogene Proteins c-akt

2019
Ebastine during pregnancy and lactation in a patient with chronic urticaria: ebastine and carebastine levels in maternal serum, cord blood, breast milk and the infant's serum.
    Journal of the European Academy of Dermatology and Venereology : JEADV, 2020, Volume: 34, Issue:9

    Topics: Animals; Butyrophenones; Chronic Urticaria; Female; Fetal Blood; Histamine H1 Antagonists; Humans; Infant; Lactation; Milk, Human; Piperidines; Pregnancy

2020
Analysis of available surface area can predict the long-term dissolution profile of tablets using short-term stability studies.
    International journal of pharmaceutics, 2020, Aug-30, Volume: 586

    Topics: Butyrophenones; Chemistry, Pharmaceutical; Drug Liberation; Drug Stability; Drug Storage; Humidity; Nonlinear Dynamics; Piperidines; Solubility; Tablets; Temperature; Time Factors

2020
Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
    Scientific reports, 2020, 12-17, Volume: 10, Issue:1

    Topics: Arachidonic Acid; Astemizole; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Docking Simulation; Oxidation-Reduction; Piperidines; Protein Binding; Substrate Specificity

2020
Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.
    Pakistan journal of pharmaceutical sciences, 2020, Volume: 33, Issue:5(Suppleme

    Topics: Administration, Oral; Bile Acids and Salts; Biological Availability; Butyrophenones; Drug Compounding; Drug Liberation; Histamine H1 Antagonists; Liposomes; Nanoparticles; Phosphatidylcholines; Piperidines; Solubility

2020
Carbopol emulgel loaded with ebastine for urticaria: development, characterization,
    Drug delivery, 2022, Volume: 29, Issue:1

    Topics: Acrylic Resins; Administration, Cutaneous; Animals; Butyrophenones; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Stability; Emulsions; Gels; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Male; Piperidines; Rabbits; Rheology; Urticaria; Viscosity

2022
Efficacy and safety of ebastine dose escalation in chronic urticaria: A prospective study.
    Dermatologic therapy, 2022, Volume: 35, Issue:5

    Topics: Butyrophenones; Cholinergic Agents; Chronic Disease; Chronic Urticaria; Headache; Histamine H1 Antagonists; Humans; Piperidines; Prospective Studies; Sleepiness; Urticaria; Xerostomia

2022
Cytochrome
    Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:11

    Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine

2022
Temporary prolongation of the QT interval in acute ebastine intoxication due to challenge video on TikTok in a girl.
    Cardiology in the young, 2023, Volume: 33, Issue:7

    Topics: Arrhythmias, Cardiac; Drug Inverse Agonism; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Infant; Long QT Syndrome; Piperidines; Social Media

2023