ebastine has been researched along with piperidines in 182 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 3 (1.65) | 18.7374 |
| 1990's | 68 (37.36) | 18.2507 |
| 2000's | 74 (40.66) | 29.6817 |
| 2010's | 27 (14.84) | 24.3611 |
| 2020's | 10 (5.49) | 2.80 |
| Authors | Studies |
|---|---|
| Hopes, H; Leopold, G; Meuret, GH; Ungethüm, W; Wiemann, H | 1 |
| Kuitunen, T; Mattila, MJ; Plétan, Y | 1 |
| Despontin, K; Ghys, L; Lachapelle, JM; Rihoux, JP; Rivest, J | 1 |
| Cadahia García, A; Cano Cantudo, L; Cisteró Bahima, A; Picado Vallés, C; Sanz Amaro, A; Zayas Sanza, JM | 1 |
| Holgate, ST; Wood-Baker, R | 1 |
| Ankier, SI; Warrington, SJ | 1 |
| Liminana, R; Meredith, PA; Reid, JL; Vincent, J | 1 |
| Reid, JL; Sumner, DJ; Vincent, J | 1 |
| Imano, K; Ishii, K; Karasawa, T; Nakamura, H; Seto, Y; Takeyama, K; Yakuo, I | 1 |
| O'Hanlon, JF; Ramaekers, JG | 1 |
| Bucher, B; Buchmeier, A; Garcia, J; Nelson, HS; Oppenheimer, J | 1 |
| Ter Laak, AM; Timmerman, H; Walczynski, K; Zhang, MQ | 1 |
| Fujii, T; Matsuda, M; Mizuki, Y; Sakashita, M; Sekine, Y; Yamaguchi, T | 1 |
| Fujii, T; Hashizume, T; Matsuda, M; Nakashima, M; Sakashita, M; Sekine, Y; Uematsu, T; Yamaguchi, T | 1 |
| de la Cuadra, J; Roma, J; Teixidó, P; Teruel, M | 1 |
| Amejima, H; Fujii, T; Hatoyama, T; Kagemoto, A; Matsumoto, S; Miyazaki, H; Nakao, M; Tanaka, K | 1 |
| Fujii, T; Hatoyama, T; Matsumoto, S; Miyazaki, H; Nomura, N; Tagawa, M; Tanaka, K | 1 |
| Fujii, T; Hatoyama, T; Kagemoto, A; Miyazaki, H; Naruto, S; Yoshida, K | 1 |
| Blanco, M; Coello, J; González, F; Iturriaga, H; Maspoch, S; Tomás, X | 1 |
| Jansat, JM; Martinez-Tobed, A; Puigdemont, A; Queralt, M | 1 |
| Simons, FE; Simons, KJ; Watson, WT | 1 |
| Aranko, K; Kuitunen, T; Mattila, MJ | 1 |
| Breimer, DD; Bruno, R; Cohen, AF; Reinhoudt, JF; Schoemaker, HC; Van Rooij, J | 1 |
| Brookhuis, KA; De Vries, G; De Waard, D | 1 |
| Timmerman, H; Walczynski, K; Zhang, MQ | 1 |
| del Prado, M; Egan, RW; Hey, JA; Kreutner, W | 2 |
| Bremard-Oury, C; Gehanno, P; Zeisser, P | 1 |
| Faulds, D; Wiseman, LR | 1 |
| Roberts, DJ | 6 |
| Storms, WW | 1 |
| Cohen, B; Gehanno, P | 1 |
| Kalis, B | 1 |
| Peláez, A | 1 |
| Conde Hernández, DJ; Delgado Romero, J; Palma Aqilar, JL | 1 |
| Böttcher, H; Hochstätter, H; Liebig-Weber, A; Schwartz, H | 1 |
| Bousquet, J; Bremard-Oury, C; Campbell, A; Crampette, L; Michel, FB | 1 |
| Jansat, JM; Lastra, CF; March, MA; Mariño, EL | 1 |
| Benavente, V; Botey, J; Eseverri, JL; Marin, A | 1 |
| Timmerman, H; Zhang, MQ | 1 |
| Ducic, I; Fan, J; Ko, CM; Morad, M; Shuba, YM | 1 |
| Llenas, J; Roberts, DJ | 1 |
| del Prado, M; Egan, RW; Hey, JA; Kreutner, W; Sherwood, J | 1 |
| Delpón, E; Franqueza, L; Gay, P; Tamargo, J; Valenzuela, C; Vicente, J | 1 |
| Brummer-Korvenkontio, H; Palosuo, T; Petman, L; Reunala, T; Sarna, S | 1 |
| Fujii, T; Hatoyama, T; Matsumoto, S; Miyazaki, H | 1 |
| Volkerts, ER | 1 |
| Benabdesselam, O; Frossard, N; Melac, M; Pauli, G | 1 |
| Luss, LV | 1 |
| Charpentier, JC; Didier, A; Melac, M; Murris-Espin, M | 1 |
| Fujii, T; Hashizume, T; Inaba, T; Mise, M; Miyazaki, H; O, L; Terauchi, Y | 1 |
| Leroy, T; Tasset, C; Valentin, B; Van Neste, D | 1 |
| Fischer, H; Gottschlich, R; Seelig, A | 1 |
| Balabolkin, II; Blokhin, BM; Goriachkina, LA; Il'ina, NI; Kolganova, NA; Pampura, AN; Sidorenko, IV | 1 |
| Bousquet, J | 1 |
| Argenti, D; Garcia, J; Heald, D; Huang, MY; Wilson, J | 1 |
| Iga, T; Kotaki, H; Ohtani, H; Sato, H; Sawada, Y | 1 |
| Mattila, MJ; Paakkari, I | 1 |
| Bousquet, J; Gaudaño, EM; Palma Carlos, AG; Staudinger, H | 1 |
| Danielson, L; DeVos, C; Grant, JA; Rihoux, JP | 1 |
| Gispert, J; Roberts, DJ | 1 |
| Chaikin, P; Garcia, JD; Gillen, M; Morganroth, J; Moss, AJ; Roberts, DJ | 1 |
| Hanada, E; Hirota, M; Iga, T; Kotaki, H; Nakaya, H; Ohtani, H; Sato, H; Sawada, Y; Uemura, H | 1 |
| Benabdesselam, O; Duvernelle, C; Frossard, N; Melac, M; Pauli, G; Purohit, A | 1 |
| López, M; Palacios, JM; Roberts, DJ; Ryder, H; Segarra, V | 1 |
| Luria, X | 1 |
| Morganroth, J; Moss, AJ | 1 |
| Hurst, M; Spencer, CM | 1 |
| Georges, GC; Lim, JC; Ratner, PH | 1 |
| Fujii, T; Funae, Y; Hashizume, T; Hiroi, T; Imaoka, S; Kamataki, T; Miyazaki, H; Terauchi, Y | 1 |
| Cho, W; Fujimura, M; Kim, KP; Kita, T; Kurashima, K; Leff, AR; Munoz, NM; Myou, S; Nakao, S; Nonomura, A; Sano, H; Shioya, T; Zhu, X | 1 |
| Kido, Y; Sai, Y; Tamai, I; Tsuji, A; Yamashita, J | 1 |
| Malik, M | 2 |
| Fujii, T; Funae, Y; Hashizume, T; Imaoka, S; Kamataki, T; Matsumoto, S; Mise, M; Miyazaki, H; Terauchi, Y | 1 |
| Aubeneau, M; Gillen, M; Jan, C; Jensen, BK; Pandit, B; Rhodes, G; Rohatagi, S | 1 |
| Matsuda, M; Mizuki, Y; Terauchi, Y | 1 |
| Frossard, N; Mounedji, N; Valleteau, A; Vital-Durand, D | 1 |
| Chaikin, P; Gillen, MS; Miller, B; Morganroth, J | 1 |
| Hashida, M; Imamura, Y; Shimizu, K; Takakura, Y; Yamaoka, K; Yamashita, F | 1 |
| Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M | 1 |
| Arai, H; Fujii, T; Higuchi, M; Ido, T; Itoh, M; Iwata, R; Kano, M; Komemushi, S; Matsuda, M; Mizuki, Y; Okamura, N; Sasaki, H; Tagawa, M; Watanabe, T; Yanai, K | 1 |
| Fujii, T; Funae, Y; Hashizume, T; Imaoka, S; Kamataki, T; Mise, M; Miyazaki, H; Terauchi, Y | 1 |
| DeVos, C; Grant, JA; Moulaert, B; Riethuisen, JM | 1 |
| Arai, H; Fujii, T; Higuchi, M; Itoh, M; Kano, M; Komemushi, S; Matsuda, M; Mizuki, Y; Okamura, N; Sasaki, H; Tagawa, M; Watanabe, T; Yanai, K | 1 |
| Ito, T; Yabuuchi, M; Yakuo, I | 1 |
| Shamsi, Z | 1 |
| Fridliand, DG; Gushchin, IS; Poroshina, IuA; Shul'zhenko, AE | 1 |
| Asaka, H; Baba, K; Yoshida, H | 1 |
| Burri, P; Karppinen, A; Kautiainen, H; Petman, L; Reunala, T | 1 |
| Paakkari, I | 1 |
| Alemán, AM; Cuesta, J; Novalbos, A; Quirce, S; Sastre, J | 1 |
| Antonijoan, R; Barbanoj, M; Esbrí, R; Garcia, E; Gich, I; Gispert, J; Luria, X | 1 |
| Frank, H; George, G; Gillen, M; Lim, J; Rohatagi, SS | 1 |
| Hirama, T; Matsubara, T; Matsumoto, S; Nagata, K; Yamazoe, Y | 1 |
| Fujisaki, Y; Itoh, Y; Oishi, R | 1 |
| Kamei, J; Miyata, S; Morita, K; Onodera, K | 1 |
| Gras, J; Llenas, J; Llupià, J | 1 |
| Gispert, J; Hampel, F; Ratner, P | 1 |
| Boyce, M; Carey, W; Luria, X; Warrington, S | 1 |
| Bousquet, J; Bremard-Oury, C; El-Akkad, T; Lund, VJ; Mounedji, N; Stevens, MT; van Cauwenberge, P | 1 |
| Dang, NH; Hosono, O; Iwata, S; Kawasaki, H; Kobayashi, H; Kobayashi, S; Morimoto, C; Munakata, Y; Nori, M; Shiohara, T; Tanaka, H; Umezawa, Y | 1 |
| Antonijoan, RM; Barbanoj, MJ; Esbrí, R; Garcia, E; García-Gea, C; Gich, I; Gispert, J; Luria, X; Morte, A | 1 |
| Morimoto, C | 1 |
| Appajosyula, S; Gelfand, EW; Meeves, S | 1 |
| Dilzer, SC; Lasseter, KC; Noveck, RJ; Vargas, R; Waldman, S | 1 |
| Hampel, F; Howland, W; Ratner, P; Van Bavel, J | 2 |
| Castillo, JA; De Molina, M; Guadaño, EM; Meseguer, J; Picado, C; Serra-Batlles, J; Valero, A | 1 |
| De Belder, T; Sys, L; Van Cauwenberge, P | 1 |
| Buisson, D; Jaouen, M; Mazier, C; Sari, MA | 1 |
| Kang, W; Liu, KH; Ryu, JY; Shin, JG | 1 |
| Chaikin, P; Gillen, MS; Malik, M; Pentikis, H; Rhodes, GR; Roberts, DJ | 1 |
| Cadahía, A; Cardona, V; Guilarte, M; Muñoz-Cano, R | 1 |
| Jeong, HE; Lee, SS; Liu, KH; Moon, T; Oh, SJ; Ryu, JY; Shin, JG; Yoon, CN; Yun, CH | 1 |
| Al-Amood, S; Elming, H | 1 |
| Chuecos, F; Esbrí, R; Falqués, M; Gispert, J; Luria, X; Peris, F; Ratner, P; Rosales, MJ | 1 |
| Benitez, J; Caballero, MJ; Carrillo, JA; Gervasini, G; Vizcaino, S | 1 |
| Choi, CS; Choi, YK; Desta, Z; Kim, MG; Kim, MJ; Lee, DJ; Liu, KH; Shin, JG; Shon, JH; Yoon, YJ | 1 |
| Codreanu, A; de Chillou, C; Moneret-Vautrin, DA | 1 |
| Chen, X; Deng, Y; Li, H | 1 |
| Noveck, RJ; Preston, RA; Swan, SK | 1 |
| Antonijoan, RM; Barbanoj, MJ; Esbri, R; Fortea, J; García-Gea, C; Puntes, M; Valle, M | 1 |
| Köberlein, J; Mösges, R | 1 |
| Antonijoan, R; Barbanoj, MJ; Esbrí, R; Fortea, J; García-Gea, C; Pérez, J; Puntes, M; Serra, C | 1 |
| Bridges, AS; Hall, JE; Kornbluth, S; Paine, MF; Tidwell, RR; Wang, MZ; Wu, JQ; Zeldin, DC | 1 |
| Lopatin, AS; Petrovskaia, TIu; Sergeeva, TA | 1 |
| Magerl, M; Maurer, M; Metz, M; Schmolke, J; Siebenhaar, F; Zuberbier, T | 2 |
| Arias Irigoyen, J; Benavente Fernández, A; Talavera Fabuel, A | 1 |
| Cheng, J; Jiang, H; Li, W; Liu, H; Tang, Y; Zhu, W | 1 |
| Devillier, P | 1 |
| Fukui, H; Izumi, N; Mizuguchi, H; Ogino, S; Umehara, H | 1 |
| de Barrio, M; Fuentes, V; Herrero, T; Sánchez, I; Tornero, P; Zubeldia, J | 1 |
| Sastre, J | 2 |
| Dundua, MM; Tsiskarishvili, NI; Tsiskarishvili, NV | 1 |
| Allaf, B; Bodez, T; Bousquet, J; Gehano, P; Janin, N; Klossek, JM; Le Gal, M; Liard, F; Neukirch, F | 1 |
| Cha, IJ; Lee, SS; Liu, KH; Shin, JG; Shon, JH; Yeo, CW | 1 |
| Amagai, M; Ohyama, M; Shimizu, A; Tanaka, K | 1 |
| Cauley, M; Cousins, V; Hampton, D; Levin, ED; Petro, A; Pruitt, M; Rose, J; Slade, S; Wells, C | 1 |
| Broccatelli, F; Carosati, E; Cruciani, G; Frosini, M; Goracci, L; Neri, A; Oprea, TI | 1 |
| Laguna Martínez, JJ; Reaño Martos, M; Rojas Pérez-Ezquerra, P; Sánchez Morillas, L; Sanz, ML | 1 |
| Bednarek, T; Elitzer, S; Kang, W; Noh, K; Weiss, M | 1 |
| Jang, YJ; Kim, HC; Kim, JH; Lee, JH | 1 |
| Fukui, H; Hattori, M; Kitamura, Y; Kuroda, W; Mizuguchi, H; Ogishi, H; Takeda, N | 1 |
| Antczak, C; Bhinder, B; Calder, PA; Djaballah, H; Mahida, JP | 1 |
| Molnár, I; Schmidt, AH | 1 |
| Das, A; Magnetta, E; McDougle, DR; Meling, DD; Palaria, A | 1 |
| Bekkali, N; Boeckxstaens, GE; de Jonge, WJ; Shi, J; Stanisor, OI; van den Wijngaard, RM; van Diest, SA; Welting, O; Yu, Z | 1 |
| Braido, F; Canonica, GW; Ferrando, M; Sclifò, F | 1 |
| Ibrahim, FA; Wahba, ME | 1 |
| Bonny, M; Goethals, L; Kindts, I; Planckaert, N; Stellamans, K | 1 |
| Abdulaeva, SN; Gadzhimirzaev, GA; Gadzhimirzaeva, RG; Shakhnazarov, MA | 1 |
| Awasthi, A; Ghosh, K; Navalgund, SG; Pandey, AK; Raju, ChK; Rapolu, R; Srinivas, K; Surendranath, KV | 1 |
| Alpizar, YA; Augustijns, P; Balemans, D; Belmans, A; Boeckxstaens, GE; Bulmer, DC; Carmeliet, P; Cibert-Goton, V; Cirillo, C; Dooley, J; Ghesquière, B; Hellings, PW; Kortekaas, I; Liston, A; Mols, R; Nasser, Y; Peetermans, WE; Rutgeerts, P; Talavera, K; Valdez-Morales, EE; Van der Merwe, S; Van Veldhoven, PP; Van Wanrooy, S; Vanbrabant, W; Vanden Berghe, P; Vanner, S; Vermeire, S; Wouters, MM | 1 |
| Inoue, T; Sasaki, E; Uehara, S; Uno, Y; Yamazaki, H; Yuki, Y | 1 |
| Ibrahim, F; Wahba, ME | 1 |
| Boeckxstaens, G; Camilleri, M | 1 |
| Frare, RG; Singh, AK | 1 |
| Gaudette, F; Huguet, J; Michaud, V; Turgeon, J | 1 |
| Jee, JG; Lee, J; Liu, KH; Park, SH; Phuc, NM; Shon, JC | 1 |
| Cui, L; Guan, K; Li, LS; Wang, RQ | 1 |
| André, F; Dansette, PM; Graves, JP; Lafite, P; Mansuy, D; Zeldin, DC | 1 |
| Chen, ML; Lee, MC; Li, CH; Lin, YY; Tsai, FM; Wang, CH; Wang, LK | 1 |
| Kamura, S; Kawasaki, H; Murashima, A; Ozawa, K; Sago, H; Saito, J; Sandaiji, N; Suzuki, T; Wada, S; Yagishita, S; Yakuwa, N; Yamatani, A | 1 |
| Hifumi, H; Hirai, D; Itai, S; Iwao, Y; Kitamura, R; Ohara, M; Takeuchi, M; Tsunematsu, H | 1 |
| Angelone, T; Avolio, E; Barbieri, A; Botti, G; De Bartolo, A; De Lorenzo, A; Gualtieri, P; Palma, G; Pasqua, T; Rocca, C; Silvestri, G | 1 |
| Chen, LY; Xu, L | 1 |
| Abbas, G; Ibrahim, HM; Ikram, M; Inam, S; Iqbal, MS; Irfan, M; Islam, N; Khan, IU; Mushtaq, M; Rasul, A; Rehman, MU; Syed, HK; Zahoor, AF | 1 |
| Abualsunun, WA; Alharbi, WS; Ali, A; Almehmady, AM; Bakhaidar, RB; Halwani, AA; Hosny, KM; Iqbal, M; Khan, BA; Khan, MK; Murshid, SSA | 1 |
| Chen, Q; Hao, F; Li, S; Qian, T; Song, Z; Zhang, D | 1 |
| Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H | 1 |
| Sert, S | 1 |
23 review(s) available for ebastine and piperidines
| Article | Year |
|---|---|
Ebastine. a review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders.
Topics: Animals; Butyrophenones; Histamine H1 Antagonists; Humans; Hypersensitivity; Piperidines | 1996 |
A preclinical overview of ebastine. Studies on the pharmacological properties of a novel histamine H1 receptor antagonist.
Topics: Animals; Butyrophenones; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Piperidines | 1996 |
Towards the optimal antihistamine: studies with ebastine.
Topics: Animals; Bronchoconstriction; Butyrophenones; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Piperidines; Potassium Channels; Rats; Structure-Activity Relationship; Terfenadine | 1998 |
Antihistamines in severe/chronic rhinitis.
Topics: Butyrophenones; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Torsades de Pointes | 1998 |
Variations among non-sedating antihistamines: are there real differences?
Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine | 1999 |
The non-cardiac systemic side-effects of antihistamines: ebastine.
Topics: Animals; Brain; Butyrophenones; Histamine H1 Antagonists; Humans; Piperidines; Psychomotor Performance | 1999 |
A review of the cardiac systemic side-effects of antihistamines: ebastine.
Topics: Adult; Butyrophenones; Child; Clinical Trials as Topic; Drug Interactions; Erythromycin; Heart; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines | 1999 |
Assessing the cardiac safety of ebastine. Prologue.
Topics: Animals; Butyrophenones; Histamine H1 Antagonists; Humans; Long QT Syndrome; Piperidines; Torsades de Pointes | 1999 |
Cardiac effects of ebastine and other antihistamines in humans.
Topics: Aged; Butyrophenones; Child; Drug Interactions; Electrocardiography; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines | 1999 |
Assessing the cardiac safety of ebastine. Epilogue.
Topics: Animals; Butyrophenones; Cation Transport Proteins; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Histamine H1 Antagonists; Humans; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Torsades de Pointes; Trans-Activators; Transcriptional Regulator ERG | 1999 |
Ebastine: an update of its use in allergic disorders.
Topics: Animals; Anti-Allergic Agents; Butyrophenones; Humans; Hypersensitivity; Piperidines | 2000 |
[The effect of second generation histamine antagonists on the heart].
Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes | 2001 |
Cardiotoxicity of new antihistamines and cisapride.
Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine | 2002 |
[Effect of H1 histamine receptor antagonists on T cell functions].
Topics: Animals; Butyrophenones; Cytokines; Histamine H1 Antagonists; Humans; Macrophages; Piperidines; T-Lymphocytes | 2003 |
Anti-inflammatory activity of H1-receptor antagonists: review of recent experimental research.
Topics: Animals; Anti-Inflammatory Agents; Butyrophenones; Cells, Cultured; Histamine H1 Antagonists; Loratadine; Piperidines; Terfenadine | 2004 |
A review of the second-generation antihistamine ebastine for the treatment of allergic disorders.
Topics: Anti-Allergic Agents; Asthma; Butyrophenones; Clinical Trials as Topic; Histamine H1 Antagonists, Non-Sedating; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria | 2004 |
Meta-analysis of the efficacy of ebastine 20 mg compared to loratadine 10 mg and placebo in the symptomatic treatment of seasonal allergic rhinitis.
Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Multicenter Studies as Topic; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Seasonal | 2005 |
Ebastine in allergic rhinitis and chronic idiopathic urticaria.
Topics: Animals; Butyrophenones; Chronic Disease; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Urticaria | 2008 |
New therapies for allergic rhinitis.
Topics: Administration, Intranasal; Androstadienes; Anti-Allergic Agents; Antibodies, Anti-Idiotypic; Antibodies, Monoclonal, Humanized; Benzimidazoles; Butyrophenones; Cyproheptadine; Fluticasone; Histamine H1 Antagonists; Humans; Omalizumab; Phthalazines; Piperidines; Pregnenediones; Rhinitis, Allergic; Rhinitis, Allergic, Perennial | 2014 |
Dietary and pharmacological treatment of abdominal pain in IBS.
Topics: Abdominal Pain; Anti-Infective Agents; Antidepressive Agents; Butyrophenones; Dipeptides; GABA Agents; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Imidazoles; Irritable Bowel Syndrome; Mentha piperita; Parasympatholytics; Phenylalanine; Piperidines; Plant Oils; Probiotics; Quaternary Ammonium Compounds; Rifamycins; Rifaximin; Serotonin 5-HT3 Receptor Antagonists; Thiophenes; Visceral Pain | 2017 |
A Critical Review of Physicochemical Properties and Analytical Methods Applied to Quantitative Determination of Ebastine.
Topics: Butyrophenones; Chemistry, Physical; Humans; Molecular Structure; Piperidines | 2018 |
Ebastine in the Treatment of Allergic Rhinitis and Urticaria: 30 Years of Clinical Studies and Real-World Experience.
Topics: Administration, Oral; Butyrophenones; Histamine; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic; Treatment Outcome; Urticaria | 2020 |
PI3Kδ Inhibition as a Potential Therapeutic Target in COVID-19.
Topics: Angiotensin-Converting Enzyme 2; Angiotensin-Converting Enzyme Inhibitors; Anti-Inflammatory Agents; Antirheumatic Agents; Antiviral Agents; Betacoronavirus; Butyrophenones; Class I Phosphatidylinositol 3-Kinases; Coronavirus Infections; COVID-19; COVID-19 Drug Treatment; Drug Repositioning; Humans; Inflammation; Interleukin-6; Molecular Targeted Therapy; Pandemics; Peptidyl-Dipeptidase A; Piperidines; Pneumonia, Viral; Purines; Quinazolinones; SARS-CoV-2 | 2020 |
63 trial(s) available for ebastine and piperidines
| Article | Year |
|---|---|
Placebo controlled comparison of acute effects of ebastine and clemastine on performance and EEG.
Topics: Adult; Butyrophenones; Clemastine; Cognition; Double-Blind Method; Electroencephalography; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance; Reference Values; Sleep; Surveys and Questionnaires; Wakefulness | 1992 |
Lack of pharmacodynamic and pharmacokinetic interactions of the antihistamine ebastine with ethanol in healthy subjects.
Topics: Adult; Butyrophenones; Double-Blind Method; Drug Interactions; Ethanol; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance | 1992 |
Pharmacological modulation by cetirizine and ebastine of the cutaneous reactivity to histamine.
Topics: Administration, Cutaneous; Administration, Oral; Adult; Butyrophenones; Capsules; Cetirizine; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hydroxyzine; Hypersensitivity; Male; Multivariate Analysis; Piperidines; Placebos; Skin; Skin Tests; Time Factors | 1991 |
Ebastine in perennial allergic rhinitis.
Topics: Adult; Butyrophenones; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial; Time Factors | 1991 |
Dose-response relationship of the H1-histamine antagonist, ebastine, against histamine and methacholine-induced bronchoconstriction in patients with asthma.
Topics: Adult; Asthma; Bronchi; Butyrophenones; Dose-Response Relationship, Drug; Female; Forced Expiratory Volume; Histamine; Histamine H1 Antagonists; Humans; Male; Methacholine Compounds; Middle Aged; Piperidines | 1990 |
A double-blind placebo-controlled study of the efficacy and tolerability of ebastine against hayfever in general practice patients.
Topics: Adult; Butyrophenones; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Seasonal | 1989 |
The pharmacokinetics, antihistamine and concentration-effect relationship of ebastine in healthy subjects.
Topics: Adult; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Male; Piperidines; Time Factors | 1988 |
Ebastine: the effect of a new antihistamine on psychomotor performance and autonomic responses in healthy subjects.
Topics: Adult; Autonomic Nervous System; Blood Pressure; Butyrophenones; Flicker Fusion; Heart Rate; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Male; Piperidines; Psychomotor Performance; Reaction Time; Salivation; Surveys and Questionnaires; Time Factors | 1988 |
Antihistamine effects on actual driving performance in a standard test: a summary of Dutch experience, 1989-94.
Topics: Automobile Driving; Benzimidazoles; Butyrophenones; Cetirizine; Clemastine; Diphenhydramine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Loratadine; Netherlands; Piperidines; Psychomotor Performance; Terfenadine; Triprolidine | 1995 |
Suppression of the skin reaction to histamine by ebastine.
Topics: Adult; Anaphylaxis; Butyrophenones; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Skin Tests | 1995 |
Assessment of the wheal size and skin blood flow of the erythema induced by histamine and its modification with cetirizine and ebastine: a crossover, double-blind study.
Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Double-Blind Method; Erythema; Female; Histamine; Histamine H1 Antagonists; Humans; Laser-Doppler Flowmetry; Male; Piperidines; Prospective Studies; Regional Blood Flow; Skin | 1994 |
Pharmacokinetics and pharmacodynamics of ebastine in children.
Topics: Butyrophenones; Child; Double-Blind Method; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial; Skin Tests | 1993 |
Diazepam effects on the performance of healthy subjects are not enhanced by treatment with the antihistamine ebastine.
Topics: Administration, Oral; Adult; Analysis of Variance; Butyrophenones; Chromatography, High Pressure Liquid; Diazepam; Double-Blind Method; Drug Interactions; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance | 1993 |
Cimetidine does not influence the metabolism of the H1-receptor antagonist ebastine to its active metabolite carebastine.
Topics: Adult; Blood Pressure; Butyrophenones; Chromatography, High Pressure Liquid; Cimetidine; Drug Interactions; Half-Life; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines | 1993 |
Acute and subchronic effects of the H1-histamine receptor antagonist ebastine in 10, 20 and 30 mg dose, and triprolidine 10 mg on car driving performance.
Topics: Adult; Automobile Driving; Butyrophenones; Double-Blind Method; Histamine H1 Antagonists; Humans; Male; Piperidines; Psychomotor Performance; Triprolidine | 1993 |
Comparison of ebastine to cetirizine in seasonal allergic rhinitis in adults.
Topics: Adult; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Seasonal | 1996 |
Clinical studies of the efficacy and tolerability of ebastine 10 or 20 mg once daily in the treatment of seasonal allergic rhinitis in the US.
Topics: Adolescent; Adult; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; United States | 1996 |
Comparison of the efficacy of ebastine 10mg and 20mg once daily with that of cetirizine 10mg once daily in adults with seasonal allergic rhinitis. A multicentre double-blind study.
Topics: Adolescent; Adult; Aged; Anti-Allergic Agents; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal | 1996 |
Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults.
Topics: Adult; Anti-Allergic Agents; Butyrophenones; Chronic Disease; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine; Urticaria | 1996 |
Clinical efficacy of ebastine in the treatment and prevention of seasonal allergic rhinitis.
Topics: Astemizole; Butyrophenones; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Seasons | 1996 |
Comparison of azelastine nasal spray and oral ebastine in treating seasonal allergic rhinitis.
Topics: Administration, Intranasal; Administration, Oral; Adolescent; Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Phthalazines; Piperidines; Rhinitis, Allergic, Seasonal; Treatment Outcome | 1995 |
Overview of allergic mechanisms. Ebastine has more than an antihistamine effect.
Topics: Adolescent; Adult; Allergens; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Histamine H1 Antagonists; Humans; Leukotriene C4; Male; Middle Aged; Nasal Polyps; Piperidines; Pollen; Prostaglandin D2; Rhinitis, Allergic, Seasonal | 1996 |
[Ebastine : treatment of perennial rhinitis in the child].
Topics: Adolescent; Butyrophenones; Carbachol; Child; Conjunctivitis, Allergic; Female; Histamine H1 Antagonists; Humans; Male; Nasal Provocation Tests; Piperidines; Rhinitis, Allergic, Perennial; Skin Tests; Treatment Outcome | 1996 |
Effect of ebastine on mosquito bites.
Topics: Adult; Aedes; Animals; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Insect Bites and Stings; Male; Middle Aged; Piperidines; Premedication | 1997 |
Consistency of the efficacy of cetirizine and ebastine on skin reactivity.
Topics: Adult; Anaphylaxis; Butyrophenones; Cetirizine; Cross-Over Studies; Dermatitis, Allergic Contact; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Male; Piperidines; Safety; Skin; Skin Tests | 1998 |
Comparison of efficacy and safety of cetirizine and ebastine in patients with perennial allergic rhinitis.
Topics: Adolescent; Adult; Aged; Butyrophenones; Cetirizine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial | 1998 |
Comparison of the effects of cetirizine and ebastine on the skin response to histamine iontophoresis monitored with laser Doppler flowmetry.
Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Iontophoresis; Laser-Doppler Flowmetry; Male; Piperidines; Skin; Skin Diseases; Skin Tests; Time Factors | 1998 |
Pharmacokinetics and electrocardiographic effect of ebastine in young versus elderly healthy subjects.
Topics: Administration, Oral; Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Analysis of Variance; Butyrophenones; Chromatography, High Pressure Liquid; Double-Blind Method; Drug Monitoring; Electrocardiography; Electrocardiography, Ambulatory; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines | 1998 |
A 12-week, placebo-controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in the treatment of perennial allergic rhinitis. Multicentre Study Group.
Topics: Adolescent; Adult; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial; Treatment Outcome | 1999 |
A double-blind, single-dose, crossover comparison of cetirizine, ebastine, epinastine, fexofenadine, terfenadine, and loratadine versus placebo: suppression of histamine-induced wheal and flare response for 24 h in healthy male subjects.
Topics: Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Dibenzazepines; Double-Blind Method; Histamine; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity, Immediate; Imidazoles; Loratadine; Male; Piperidines; Skin Tests; Terfenadine; Urticaria | 1999 |
Consistency and efficacy of cetirizine (10 mg) versus ebastine (20 mg) at 4 h on skin reactivity.
Topics: Adolescent; Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Skin Tests | 1999 |
Comparative clinical studies with ebastine: efficacy and tolerability.
Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Electrocardiography; Electrocardiography, Ambulatory; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 1999 |
Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis. The Ebastine Study Group.
Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Loratadine; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal | 2000 |
Problems of heart rate correction in assessment of drug-induced QT interval prolongation.
Topics: Butyrophenones; Cross-Over Studies; Drug Evaluation; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Long QT Syndrome; Models, Cardiovascular; Piperidines; Regression Analysis | 2001 |
Effect of age and gender on the pharmacokinetics of ebastine after single and repeated dosing in healthy subjects.
Topics: Administration, Oral; Adult; Age Factors; Aged; Aged, 80 and over; Area Under Curve; Butyrophenones; Drug Administration Schedule; Female; Histamine H1 Antagonists; Humans; Male; Mass Spectrometry; Middle Aged; Piperidines; Sex Factors | 2001 |
Duration of the antihistaminic effect after discontinuation of ebastine.
Topics: Adolescent; Adult; Butyrophenones; Confidence Intervals; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Time and Motion Studies; Time Factors | 2001 |
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval.
Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Male; Piperidines; Terfenadine | 2001 |
Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine.
Topics: Adult; Butyrophenones; Carbon Radioisotopes; Cerebral Cortex; Chlorpheniramine; Cross-Over Studies; Histamine H1 Antagonists; Humans; Male; Models, Biological; Piperidines; Receptors, Histamine H1; Single-Blind Method; Thalamus; Tomography, Emission-Computed; Treatment Outcome | 2001 |
A double-blind, randomized, single-dose, crossover comparison of levocetirizine with ebastine, fexofenadine, loratadine, mizolastine, and placebo: suppression of histamine-induced wheal-and-flare response during 24 hours in healthy male subjects.
Topics: Adult; Benzimidazoles; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Piperidines; Terfenadine; Treatment Outcome; Urticaria | 2002 |
Differential cognitive effects of ebastine and (+)-chlorpheniramine in healthy subjects: correlation between cognitive impairment and plasma drug concentration.
Topics: Administration, Oral; Adult; Butyrophenones; Chlorpheniramine; Cognition; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Humans; Male; Piperidines; Reaction Time; Sleep; Stereoisomerism; Visual Perception | 2002 |
The effects of single and repeated administration of ebastine on cognition and psychomotor performance in comparison to triprolidine and placebo in healthy volunteers.
Topics: Adult; Analysis of Variance; Butyrophenones; Cognition; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Piperidines; Psychomotor Performance; Triprolidine | 2001 |
[Clinical efficacy of Ebastine under placebo-controlled outdoors clinical study on cedar pollinosis].
Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Single-Blind Method | 2002 |
Comparison of cetirizine, ebastine and loratadine in the treatment of immediate mosquito-bite allergy.
Topics: Adult; Animals; Butyrophenones; Cetirizine; Conscious Sedation; Cross-Over Studies; Culicidae; Double-Blind Method; Finland; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Insect Bites and Stings; Loratadine; Middle Aged; Piperidines; Pruritus; Severity of Illness Index; Time Factors; Treatment Outcome | 2002 |
Efficacy of ebastine, cetirizine, and loratadine in histamine cutaneous challenges.
Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Kinetics; Loratadine; Male; Middle Aged; Piperidines; Skin Tests | 2002 |
A double-blind, placebo-controlled study of the efficacy and safety of ebastine 20 mg once daily given with and without food in the treatment of seasonal allergic rhinitis.
Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Food-Drug Interactions; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2002 |
Efficacy of ebastine in the control of nasal congestion associated with allergic rhinitis.
Topics: Adult; Ambrosia; Butyrophenones; Dose-Response Relationship, Drug; Double-Blind Method; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Male; Nasal Obstruction; Piperidines; Rhinitis, Allergic, Seasonal | 2003 |
Inhibition of the histamine wheal by ebastine compared with cetirizine, fexofenadine and loratadine at steady state.
Topics: Adolescent; Adult; Butyrophenones; Cetirizine; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Injections, Intradermal; Loratadine; Male; Piperidines; Skin Tests; Terfenadine | 2002 |
Implementation of guidelines for seasonal allergic rhinitis: a randomized controlled trial.
Topics: Administration, Intranasal; Administration, Oral; Adult; Anti-Allergic Agents; Butyrophenones; Conjunctivitis, Allergic; Female; Glucocorticoids; Guideline Adherence; Histamine H1 Antagonists; Humans; Male; Nedocromil; Piperidines; Practice Guidelines as Topic; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Triamcinolone Acetonide | 2003 |
A study comparing the inhibitory effects of single and repeated oral doses of ebastine and fexofenadine against histamine-induced skin reactivity.
Topics: Administration, Oral; Adolescent; Adult; Butyrophenones; Double-Blind Method; Female; Histamine Antagonists; Humans; Male; Middle Aged; Piperidines; Skin; Terfenadine | 2003 |
Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers: a phase I open-label study.
Topics: Adult; Area Under Curve; Butyrophenones; Case-Control Studies; Female; Half-Life; Histamine H1 Antagonists; Humans; Intestinal Absorption; Liver Diseases; Male; Metabolic Clearance Rate; Middle Aged; Piperidines | 2004 |
Efficacy and safety of ebastine 20 mg compared to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis: a randomized, double-blind, placebo-controlled study.
Topics: Adolescent; Adult; Aged; Butyrophenones; Child; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Least-Squares Analysis; Loratadine; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal | 2004 |
A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of ebastine (20 mg and 10 mg) to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis.
Topics: Administration, Oral; Butyrophenones; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Loratadine; Male; Multivariate Analysis; Patch Tests; Piperidines; Probability; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2004 |
Rupatadine 10 mg and ebastine 10 mg in seasonal allergic rhinitis: a comparison study.
Topics: Adolescent; Adult; Analysis of Variance; Anti-Allergic Agents; Butyrophenones; Cyproheptadine; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Severity of Illness Index; Treatment Outcome | 2004 |
Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects.
Topics: Adolescent; Adult; Antifungal Agents; Butyrophenones; Double-Blind Method; Drug Combinations; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Ketoconazole; Loratadine; Male; Piperidines | 2005 |
A comparison of ebastine 10 mg fast-dissolving tablet with oral desloratadine and placebo in inhibiting the cutaneous reaction to histamine in healthy adults.
Topics: Adult; Butyrophenones; Chemistry, Pharmaceutical; Dermatitis, Contact; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Patient Acceptance of Health Care; Piperidines; Skin; Tablets; Treatment Outcome | 2007 |
[New generation antihistamines as monotherapy or in combination. What is the relevance for daily clinical routine for allergic rhinoconjunctivitis].
Topics: Adrenal Cortex Hormones; Adult; Butyrophenones; Conjunctivitis; Drug Combinations; Female; Germany; Histamine H1 Antagonists; Humans; Male; Piperidines; Practice Patterns, Physicians'; Prevalence; Rhinitis, Allergic, Seasonal; Treatment Outcome | 2007 |
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
Topics: Adolescent; Adult; Butyrophenones; Cross-Over Studies; Double-Blind Method; Female; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Male; Pain Measurement; Piperidines; Pruritus; Skin; Skin Tests | 2007 |
Acquired cold urticaria symptoms can be safely prevented by ebastine.
Topics: Adult; Affect; Butyrophenones; Cold Temperature; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Psychometrics; Treatment Outcome; Urticaria | 2007 |
Prevention of signs and symptoms of dermographic urticaria by single-dose ebastine 20 mg.
Topics: Adult; Affect; Aged; Butyrophenones; Cognition; Cross-Over Studies; Double-Blind Method; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Physical Stimulation; Pilot Projects; Piperidines; Psychometrics; Treatment Outcome; Urticaria | 2009 |
Implementation of guidelines for allergic rhinitis in specialist practices. A randomized pragmatic controlled trial.
Topics: Adolescent; Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Practice Guidelines as Topic; Practice Patterns, Physicians'; Quality of Life; Rhinitis, Allergic, Seasonal; Surveys and Questionnaires; Young Adult | 2009 |
Itraconazole and rifampin alter significantly the disposition and antihistamine effect of ebastine and its metabolites in healthy participants.
Topics: Adult; Antifungal Agents; Butyrophenones; Cross-Over Studies; Drug Interactions; Enzyme Inhibitors; Histamine; Histamine H1 Antagonists; Humans; Hypersensitivity, Immediate; Itraconazole; Male; Piperidines; Rifampin; Skin; Young Adult | 2010 |
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.
Topics: Abdominal Pain; Adolescent; Adult; Aged; Analgesics; Belgium; Biopsy; Butyrophenones; Calcium Signaling; Double-Blind Method; Female; Gastrointestinal Agents; Histamine H1 Antagonists; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Neurons; Pain Measurement; Pain Threshold; Piperidines; Quality of Life; Receptor Cross-Talk; Receptors, Histamine H1; Rectum; Remission Induction; Surveys and Questionnaires; Time Factors; Treatment Outcome; TRPV Cation Channels; Young Adult | 2016 |
[Effects of double-dose antihistamine or combined therapy in allergic rhinitis].
Topics: Administration, Intranasal; Anti-Allergic Agents; Butyrophenones; Double-Blind Method; Drug Therapy, Combination; Histamine H1 Antagonists; Humans; Mometasone Furoate; Piperidines; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal | 2018 |
96 other study(ies) available for ebastine and piperidines
| Article | Year |
|---|---|
[Pharmacological study of ebastine, a novel histamine H1-receptor antagonist].
Topics: Administration, Oral; Animals; Butyrophenones; Disease Models, Animal; Dose-Response Relationship, Drug; Guinea Pigs; Histamine H1 Antagonists; Histamine Release; Humans; Hypersensitivity; In Vitro Techniques; Male; Phenothiazines; Piperidines; Pyrilamine; Rats; Rats, Wistar; Terfenadine | 1994 |
Optically active analogues of ebastine: synthesis and effect of chirality on their antihistaminic and antimuscarinic activity.
Topics: Animals; Butyrophenones; Guinea Pigs; Histamine; Histamine H1 Antagonists; Ileum; In Vitro Techniques; Models, Molecular; Muscarinic Antagonists; Piperidines; Receptors, Histamine H1; Receptors, Muscarinic; Stereoisomerism | 1994 |
Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys.
Topics: Administration, Oral; Animals; Butyrophenones; Dogs; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Macaca fascicularis; Male; Piperidines; Protein Binding; Rats; Rats, Wistar; Species Specificity | 1994 |
Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects.
Topics: Adult; Butyrophenones; Food; Half-Life; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Protein Binding | 1994 |
Absorption, distribution, metabolism and excretion of [14C]ebastine after a single administration in rats.
Topics: Administration, Oral; Animals; Autoradiography; Bile; Blood Proteins; Butyrophenones; Chromatography, Thin Layer; Feces; Female; Half-Life; Histamine H1 Antagonists; Humans; Injections, Intravenous; Intestinal Absorption; Male; Milk; Piperidines; Pregnancy; Protein Binding; Rats; Rats, Wistar; Tissue Distribution | 1994 |
Absorption, distribution, metabolism and excretion of [14C]ebastine after repeated oral administration in rats.
Topics: Administration, Oral; Animals; Autoradiography; Behavior, Animal; Biotransformation; Butyrophenones; Chromatography, Thin Layer; Eating; Histamine H1 Antagonists; Intestinal Absorption; Male; Piperidines; Rats; Rats, Wistar; Tissue Distribution; Weight Gain | 1994 |
Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry.
Topics: Animals; Biotransformation; Butyrophenones; Chromatography, Thin Layer; Feces; Histamine H1 Antagonists; Hydrolysis; Hydroxylation; Magnetic Resonance Spectroscopy; Male; Mass Spectrometry; Oxidation-Reduction; Piperidines; Rats; Rats, Wistar; Sulfates | 1994 |
Spectrophotometric determination of pharmaceutical dosages by partial least-squares calibration.
Topics: Butyrophenones; Excipients; Histamine H1 Antagonists; Indicators and Reagents; Least-Squares Analysis; Nephelometry and Turbidimetry; Parabens; Piperidines; Spectrophotometry, Ultraviolet | 1994 |
Pharmacokinetic and pharmacodynamic studies of the histamine H1-receptor antagonist ebastine in dogs.
Topics: Administration, Oral; Analysis of Variance; Animals; Biological Availability; Butyrophenones; Chromatography, High Pressure Liquid; Dogs; Half-Life; Histamine H1 Antagonists; Injections, Intradermal; Male; Piperidines; Skin | 1994 |
A steric approach for the design of antihistamines with low muscarinic receptor antagonism.
Topics: Animals; Butyrophenones; Drug Design; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Molecular Structure; Muscarinic Antagonists; Piperidines; Stereoisomerism; Structure-Activity Relationship | 1995 |
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects.
Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine | 1996 |
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; Electrocardiography; Guinea Pigs; Heart Diseases; Histamine H1 Antagonists; Ketoconazole; Liver; Male; Mixed Function Oxygenases; Piperidines; Terfenadine; Torsades de Pointes | 1996 |
Microbial oxidation of ebastine.
Topics: Biotransformation; Butyrophenones; Histamine H1 Antagonists; Mucorales; Oxidation-Reduction; Piperidines | 1996 |
Parametrization by nonlinear regression analysis of the active acid metabolite of ebastine using different weighting methods.
Topics: Administration, Oral; Adolescent; Adult; Area Under Curve; Butyrophenones; Half-Life; Histamine H1 Antagonists; Humans; Male; Metabolic Clearance Rate; Piperidines; Regression Analysis | 1996 |
Leukotriene cysLT1 (LTD4) receptor antagonism of H1-antihistamines: an in vitro study.
Topics: Animals; Butyrophenones; Cell Membrane; Chromones; Cyproheptadine; Guinea Pigs; Histamine H1 Antagonists; Ileum; Leukotriene Antagonists; Leukotriene D4; Lung; Membrane Proteins; Muscle Contraction; Phthalazines; Piperidines; Receptors, Leukotriene | 1997 |
Suppression of mammalian K+ channel family by ebastine.
Topics: Animals; Butyrophenones; Electrocardiography; Guinea Pigs; Heart; Histamine H1 Antagonists; Male; Piperidines; Potassium Channel Blockers; Potassium Channels; Rats; Rats, Wistar; Xenopus laevis | 1997 |
Some observations on the cardiotoxic and drug interaction profiles of second generation antihistamines as measured in the guinea pig.
Topics: Animals; Antifungal Agents; Butyrophenones; Disease Models, Animal; Drug Interactions; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Injections, Intravenous; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes | 1996 |
The guinea pig model for assessing cardiotoxic proclivities of second generation antihistamines.
Topics: Animals; Antifungal Agents; Butyrophenones; Cats; Disease Models, Animal; Drug Interactions; Guinea Pigs; Histamine H1 Antagonists; Humans; Ketoconazole; Piperidines; Terfenadine; Torsades de Pointes | 1996 |
Comparative effects of nonsedating histamine H1 receptor antagonists, ebastine and terfenadine, on human Kv1.5 channels.
Topics: Animals; Butyrophenones; Cells, Cultured; Drug Evaluation, Preclinical; Histamine H1 Antagonists; Humans; Membrane Potentials; Mice; Patch-Clamp Techniques; Piperidines; Potassium Channels; Terfenadine | 1997 |
Studies on the first-pass metabolism of ebastine in rats.
Topics: Animals; Biological Availability; Biotransformation; Butyrophenones; Chromatography, Thin Layer; Femoral Vein; Half-Life; Histamine H1 Antagonists; Infusions, Intravenous; Intestinal Absorption; Intestine, Small; Liver; Male; Piperidines; Portal Vein; Rats; Rats, Wistar | 1997 |
Comparison of ebastine with cetirizine.
Topics: Adult; Butyrophenones; Cetirizine; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal | 1997 |
[The diagnosis and drug therapy of allergic dermatoses].
Topics: Butyrophenones; Dermatitis, Allergic Contact; Drug Evaluation; Histamine H1 Antagonists; Humans; Moscow; Piperidines; Prevalence | 1998 |
N-Dealkylation and hydroxylation of ebastine by human liver cytochrome P450.
Topics: Butyrophenones; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Histamine H1 Antagonists; Humans; Hydroxylation; Microsomes, Liver; Piperidines | 1998 |
Blood-brain barrier permeation: molecular parameters governing passive diffusion.
Topics: Air; Amiodarone; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Brain; Butyrophenones; Diffusion; Domperidone; Histamine H1 Antagonists; Humans; Kinetics; Loperamide; Micelles; Models, Biological; Piperidines; Surface Properties; Thermodynamics; Water | 1998 |
[Ebastine in the treatment of seasonal allergic rhinitis].
Topics: Administration, Oral; Adolescent; Adult; Aged; Butyrophenones; Child; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Male; Middle Aged; Piperidines; Rhinitis, Allergic, Seasonal; Treatment Outcome | 1998 |
Pharmacokinetic-pharmacodynamic analysis of the arrhythmogenic potency of a novel antiallergic agent, ebastine, in rats.
Topics: Animals; Arrhythmias, Cardiac; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Male; Piperidines; Rats; Rats, Sprague-Dawley; Terfenadine | 1999 |
Cardiotoxicity of second-generation antihistamines.
Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine | 1999 |
Inhibitory effects of the antihistamines epinastine, terfenadine, and ebastine on potassium currents in rat ventricular myocytes.
Topics: Animals; Butyrophenones; Dibenzazepines; Electrophysiology; Heart Ventricles; Histamine H1 Antagonists; Imidazoles; Male; Patch-Clamp Techniques; Piperidines; Potassium Channels; Rats; Rats, Sprague-Dawley; Terfenadine | 1999 |
Computer-assisted comparison of the structural and electronic dispositions of ebastine and terfenadine.
Topics: Butyrophenones; Histamine H1 Antagonists; Models, Molecular; Molecular Conformation; Piperidines; Signal Processing, Computer-Assisted; Terfenadine | 1999 |
cDNA cloning and expression of a novel cytochrome p450 (cyp4f12) from human small intestine.
Topics: Amino Acid Sequence; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Base Sequence; Butyrophenones; Catalysis; Cloning, Molecular; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; DNA, Complementary; Gene Library; Humans; Intestine, Small; Leukotriene B4; Liver; Mixed Function Oxygenases; Molecular Sequence Data; Piperidines; Protein Isoforms; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2001 |
Blockade of eosinophil migration and airway hyperresponsiveness by cPLA2-inhibition.
Topics: Animals; Antigens; Azepines; Benzoquinones; Bronchoconstriction; Butyrophenones; Eicosapentaenoic Acid; Enzyme Inhibitors; Eosinophils; Guinea Pigs; Indomethacin; Male; Methacholine Chloride; Phospholipases A; Phospholipases A2; Piperidines; Respiratory Hypersensitivity; Triazoles | 2001 |
Blood-brain barrier transport of H1-antagonist ebastine and its metabolite carebastine.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Blood-Brain Barrier; Butyrophenones; Cattle; Endothelium, Vascular; Histamine H1 Antagonists; Humans; Male; Mice; Mice, Mutant Strains; Piperidines; Rats; Rats, Sprague-Dawley; Tumor Cells, Cultured | 2000 |
A novel cytochrome P450 enzyme responsible for the metabolism of ebastine in monkey small intestine.
Topics: Amino Acid Sequence; Animals; Butyrophenones; Cytochrome P-450 Enzyme System; Electrophoresis, Polyacrylamide Gel; Histamine H1 Antagonists; Hydroxylation; Intestine, Small; Macaca fascicularis; Male; Microsomes; Molecular Sequence Data; Piperidines; Sequence Homology, Amino Acid | 2001 |
Simultaneous determination of the histamine H1-receptor antagonist ebastine and its two metabolites, carebastine and hydroxyebastine, in human plasma using high-performance liquid chromatography.
Topics: Butyrophenones; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Humans; Piperidines; Reproducibility of Results; Sensitivity and Specificity | 2001 |
Transport characteristics of ebastine and its metabolites across human intestinal epithelial Caco-2 cell monolayers.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport, Active; Butyrophenones; Caco-2 Cells; Cyclosporine; Histamine H1 Antagonists; Humans; Immunosuppressive Agents; Piperidines | 2001 |
Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes.
Topics: Antibodies, Blocking; Arachidonic Acid; Aryl Hydrocarbon Hydroxylases; Butyrophenones; Cloning, Molecular; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; Enzyme Inhibitors; Histamine H1 Antagonists; Humans; In Vitro Techniques; Intestinal Mucosa; Intestines; Kinetics; Leukotriene B4; Microsomes; Mixed Function Oxygenases; Oxygenases; Piperidines; Recombinant Proteins | 2002 |
Preclinical comparison of ebastine and other second generation H1-antihistamines.
Topics: Animals; Butyrophenones; Cerebral Cortex; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Guinea Pigs; Histamine H1 Antagonists; Intracellular Membranes; Male; Passive Cutaneous Anaphylaxis; Piperidines; Pyrilamine; Rats; Rats, Wistar; Receptors, Histamine H1; Skin | 2001 |
[Comparative antihistamine and anti-allergic effects of various antihistamine preparations].
Topics: Adult; Anti-Allergic Agents; Butyrophenones; Cetirizine; Clemastine; Female; Histamine H1 Antagonists; Humans; Hypersensitivity; Loratadine; Male; Piperidines; Pollen; Terfenadine | 2002 |
Anaphylactoid reaction caused by moxifloxacin.
Topics: Adult; Anaphylaxis; Anti-Infective Agents; Aza Compounds; Butyrophenones; Female; Fluoroquinolones; Humans; Moxifloxacin; Otitis; Piperidines; Quinolines | 2002 |
[Antihistamines. How safe are they?].
Topics: Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Urticaria | 2002 |
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
Topics: Animals; Antibodies, Blocking; Arachidonic Acid; Astemizole; Blotting, Western; Butyrophenones; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Cloning, Molecular; COS Cells; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; DNA, Complementary; Enzyme Inhibitors; Gene Library; Histamine H1 Antagonists; Humans; In Vitro Techniques; Intestinal Mucosa; Mass Spectrometry; Microsomes, Liver; Oxygenases; Piperidines; Rabbits; Recombinant Proteins | 2002 |
Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval.
Topics: Butyrophenones; Electrocardiography; Heart Rate; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine | 2002 |
In vivo evidence for a lack of central effect of ebastine, an antihistaminic agent, in rats: a microdialysis study.
Topics: Animals; Butyrophenones; Chlorpheniramine; Corpus Striatum; Dopamine; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Histamine H1 Antagonists; In Vitro Techniques; Male; Microdialysis; Nomifensine; Piperidines; Rats; Rats, Wistar | 2002 |
Effects of second generation of histamine H1 antagonists, cetirizine and ebastine, on the antitussive and rewarding effects of dihydrocodeine in mice.
Topics: Animals; Antitussive Agents; Butyrophenones; Cetirizine; Codeine; Dopamine; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Limbic System; Male; Mice; Mice, Inbred ICR; Piperidines; Receptors, Dopamine D1; Reward | 2003 |
Comparative antiallergic effects of second-generation H1-antihistamines ebastine, cetirizine and loratadine in preclinical models.
Topics: Aerosols; Airway Resistance; Algorithms; Animals; Anti-Allergic Agents; Bronchial Spasm; Butyrophenones; Cetirizine; Guinea Pigs; Histamine; Histamine H1 Antagonists; Leukotriene C4; Loratadine; Male; Ovalbumin; Piperidines | 2003 |
[Antihistaminics. Side effects also after raising dosage at the placebo level].
Topics: Anti-Allergic Agents; Benzimidazoles; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Meta-Analysis as Topic; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal | 2003 |
[In seasonal and perennial rhinitis. Superiority to standard H1 blockers].
Topics: Anti-Allergic Agents; Butyrophenones; Cetirizine; Double-Blind Method; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Loratadine; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Time Factors | 2003 |
Ebastine inhibits T cell migration, production of Th2-type cytokines and proinflammatory cytokines.
Topics: Antigens, CD; Butyrophenones; Cell Division; Cell Movement; Cells, Cultured; Cytokines; Dose-Response Relationship, Immunologic; Endothelium; Histamine H1 Antagonists, Non-Sedating; Humans; Ketotifen; Lymphocyte Activation; Macrophages; Piperidines; T-Lymphocyte Subsets; Th1 Cells; Th2 Cells | 2003 |
Microbial oxidation of terfenadine and ebastine into fexofenadine and carebastine.
Topics: Absidia; Biotransformation; Butyrophenones; Cunninghamella; Histamine H1 Antagonists; Oxidation-Reduction; Piperidines; Streptomyces griseus; Terfenadine | 2004 |
Simultaneous determination of ebastine and its three metabolites in plasma using liquid chromatography-tandem mass spectrometry.
Topics: Butyrophenones; Chromatography, Liquid; Histamine H1 Antagonists; Humans; Mass Spectrometry; Piperidines; Sensitivity and Specificity | 2004 |
Safety of ebastine.
Topics: Arrhythmias, Cardiac; Butyrophenones; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis; Treatment Outcome; Urticaria | 2005 |
Antihistamines and driving ability: evidence from on-the-road driving studies during normal traffic.
Topics: Animals; Arrhythmias, Cardiac; Automobile Driving; Butyrophenones; Electrocardiography; Histamine H1 Antagonists; Humans; Models, Animal; Piperidines; Potassium Channels; Time Factors | 2005 |
Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity.
Topics: Alleles; Animals; Astemizole; Butyrophenones; Catalysis; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA Primers; Dose-Response Relationship, Drug; Gene Frequency; Genetic Variation; Heterozygote; Histamine H1 Antagonists; Humans; Insecta; Kinetics; Korea; Methylation; Models, Molecular; Mutation; Oxygenases; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Recombinant Proteins; Recombination, Genetic; Sequence Analysis, DNA; Time Factors | 2005 |
[Cardiac arrest following treatment with non-cardiologic QT-interval-increasing medications].
Topics: Bendroflumethiazide; Butyrophenones; Cisapride; Diuretics; Electrocardiography; Female; Furosemide; Gastrointestinal Agents; Heart Arrest; Histamine H1 Antagonists; Humans; Middle Aged; Piperidines; Potassium Chloride; Sodium Chloride Symporter Inhibitors; Torsades de Pointes | 2005 |
The effect of CYP2J2, CYP3A4, CYP3A5 and the MDR1 polymorphisms and gender on the urinary excretion of the metabolites of the H-receptor antihistamine ebastine: a pilot study.
Topics: Administration, Oral; Adolescent; Adult; ATP Binding Cassette Transporter, Subfamily B, Member 1; Beverages; Body Weight; Butyrophenones; Citrus paradisi; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Female; Genotype; Histamine H1 Antagonists; Humans; Male; Oxygenases; Pilot Projects; Piperidines; Polymorphism, Restriction Fragment Length; Sex Factors | 2006 |
Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A.
Topics: Butyrophenones; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Histamine H1 Antagonists; Humans; In Vitro Techniques; Microsomes, Liver; Oxygenases; Piperidines | 2006 |
Long QT syndrome in a patient with allergic rhinoconjunctivitis and auto-immune diabetes: focus on the choice of anti-H1 drugs.
Topics: Adolescent; Adrenergic beta-Antagonists; Anti-Asthmatic Agents; Butyrophenones; Cetirizine; Conjunctivitis, Allergic; Cromolyn Sodium; Diabetes Mellitus, Type 1; Heart; Histamine H1 Antagonists; Humans; Long QT Syndrome; Male; Piperazines; Piperidines; Rhinitis, Allergic, Seasonal; Terfenadine | 2006 |
Palmoplantar pityriasis rosea: two case reports.
Topics: Adrenal Cortex Hormones; Adult; Butyrophenones; Diagnosis, Differential; Female; Foot Dermatoses; Hand Dermatoses; Histamine H1 Antagonists; Humans; Piperidines; Pityriasis Rosea | 2007 |
Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment.
Topics: Administration, Oral; Adult; Aged; Area Under Curve; Butyrophenones; Drug Administration Schedule; Drug Monitoring; Electrocardiography; Female; Half-Life; Histamine H1 Antagonists; Humans; Kidney Function Tests; Male; Middle Aged; Piperidines; Renal Insufficiency | 2007 |
Human enteric microsomal CYP4F enzymes O-demethylate the antiparasitic prodrug pafuramidine.
Topics: Amidines; Antibodies; Antiparasitic Agents; Arachidonic Acid; Benzamidines; Benzoflavones; Butyrophenones; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP4A; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Cytochrome P450 Family 4; Enzyme Inhibitors; Fatty Acids, Unsaturated; Humans; Hydroxyeicosatetraenoic Acids; Intestinal Mucosa; Intestines; Kinetics; Methylation; Microsomes; Oxygenases; Piperidines; Prodrugs; Recombinant Proteins; Stereoisomerism | 2007 |
[Ebastine (kestine 20) in therapy of allergic rhinitis].
Topics: Adult; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Piperidines; Rhinitis, Allergic, Perennial | 2007 |
[Ebastine-induced hepatotoxicity].
Topics: Butyrophenones; Chemical and Drug Induced Liver Injury; Female; Histamine H1 Antagonists; Humans; Middle Aged; Piperidines | 2007 |
Probing ligand binding modes of human cytochrome P450 2J2 by homology modeling, molecular dynamics simulation, and flexible molecular docking.
Topics: Amino Acid Sequence; Binding Sites; Butyrophenones; Computer Simulation; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Design; Humans; Ligands; Models, Molecular; Molecular Sequence Data; Oxygenases; Piperidines; Protein Interaction Domains and Motifs; Sequence Alignment; Structural Homology, Protein; Substrate Specificity; Terfenadine | 2008 |
Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet [20 mg] versus desloratadine capsule [5 mg]: a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adult
Topics: Butyrophenones; Histamine; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Randomized Controlled Trials as Topic; Skin Tests | 2007 |
Analysis of disease-dependent sedative profiles of H(1)-antihistamines by large-scale surveillance using the visual analog scale.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Asthma; Butyrophenones; Cetirizine; Child; Chlorpheniramine; Dermatitis, Atopic; Dibenzazepines; Dibenzoxepins; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Imidazoles; Japan; Male; Middle Aged; Olopatadine Hydrochloride; Pain Measurement; Piperidines; Population Surveillance; Psychomotor Performance; Pyridines; Quality of Life; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Sleep Stages; Surveys and Questionnaires; Terfenadine; Urticaria | 2008 |
Anaphylaxis to oral iron salts. desensitization protocol for tolerance induction.
Topics: Aged; Anaphylaxis; Butyrophenones; Chlorpheniramine; Desensitization, Immunologic; Drug Hypersensitivity; Female; Ferrous Compounds; Histamine H1 Antagonists; Humans; Lactates; Piperidines | 2008 |
[Avene-50 and Ebastine in treatment and prevention of photodermatosis].
Topics: Adolescent; Adult; Aged; Butyrophenones; Female; Histamine H1 Antagonists; Humans; Male; Middle Aged; Mineral Waters; Photosensitivity Disorders; Piperidines; Sunscreening Agents; Young Adult | 2009 |
Experimental evaluation of ebastine, a second-generation anti-histamine, as a supportive medication for alopecia areata.
Topics: Adult; Alopecia Areata; Animals; Butyrophenones; Disease Models, Animal; Female; Histamine Antagonists; Humans; Immunotherapy; Mice; Mice, Inbred C3H; Piperidines; Remission Induction; Treatment Outcome | 2010 |
Histamine H(1) antagonist treatment with pyrilamine reduces nicotine self-administration in rats.
Topics: Animals; Butyrophenones; Drug Administration Schedule; Female; Follow-Up Studies; Food; Histamine; Histamine H1 Antagonists; Infusion Pumps; Injections; Motivation; Nicotine; Piperidines; Pyrilamine; Rats; Rats, Sprague-Dawley; Self Administration; Tobacco Use Disorder | 2011 |
A novel approach for predicting P-glycoprotein (ABCB1) inhibition using molecular interaction fields.
Topics: Animals; Aripiprazole; ATP Binding Cassette Transporter, Subfamily B, Member 1; Butyrophenones; Cell Line, Tumor; Cell Membrane Permeability; Drug Design; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Mice; Models, Molecular; Molecular Structure; Piperazines; Piperidines; Protein Binding; Quantitative Structure-Activity Relationship; Quinolones | 2011 |
Urticaria due to antihistamines.
Topics: Administration, Oral; Butyrophenones; Diagnosis, Differential; Drug Hypersensitivity; Female; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Middle Aged; Piperidines; Terfenadine; Urticaria | 2011 |
Myocardial pharmacokinetics of ebastine, a substrate for cytochrome P450 2J, in rat isolated heart.
Topics: Animals; Butyrophenones; Cytochrome P-450 Enzyme System; Heart; Histamine H1 Antagonists; In Vitro Techniques; Male; Models, Chemical; Myocardium; Piperidines; Rats; Rats, Wistar | 2011 |
Maxillary sinus hypoplasia with a patent ostiomeatal complex: A therapeutic dilemma.
Topics: Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents; Butyrophenones; Clarithromycin; Cohort Studies; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Male; Maxillary Sinus; Maxillary Sinusitis; Middle Aged; Nasal Mucosa; Piperidines; Tomography, X-Ray Computed; Young Adult | 2012 |
Preseasonal prophylactic treatment with antihistamines suppresses IL-5 but not IL-33 mRNA expression in the nasal mucosa of patients with seasonal allergic rhinitis caused by Japanese cedar pollen.
Topics: Butyrophenones; Cryptomeria; Female; Histamine Antagonists; Humans; Interleukin-33; Interleukin-5; Interleukins; Male; Middle Aged; Nasal Mucosa; Piperidines; Pollen; Rhinitis, Allergic, Seasonal; Terfenadine | 2012 |
A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery.
Topics: Anti-Inflammatory Agents; Beclomethasone; Biosensing Techniques; Butyrophenones; Cell Line; Dose-Response Relationship, Drug; Drug Discovery; ErbB Receptors; Flurandrenolone; High-Throughput Screening Assays; Histamine H1 Antagonists; Humans; Permeability; Piperidines; Quinazolines; Receptors, Vascular Endothelial Growth Factor; Reproducibility of Results; Signal-To-Noise Ratio | 2012 |
Using an innovative Quality-by-Design approach for development of a stability indicating UHPLC method for ebastine in the API and pharmaceutical formulations.
Topics: Butyrophenones; Chromatography, High Pressure Liquid; Histamine H1 Antagonists; Limit of Detection; Pharmaceutical Preparations; Piperidines; Reproducibility of Results | 2013 |
Functional studies of N-terminally modified CYP2J2 epoxygenase in model lipid bilayers.
Topics: Amino Acid Sequence; Butyrophenones; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Escherichia coli; Humans; Hydroxylation; Lipid Bilayers; Models, Molecular; Molecular Sequence Data; Mutation; NADP; Nanostructures; Oxidation-Reduction; Piperidines; Protein Binding; Sequence Alignment | 2013 |
Stress-induced visceral hypersensitivity in maternally separated rats can be reversed by peripherally restricted histamine-1-receptor antagonists.
Topics: Animals; Blotting, Western; Butyrophenones; Dose-Response Relationship, Drug; Histamine H1 Antagonists; Irritable Bowel Syndrome; Mast Cells; Maternal Deprivation; Occludin; Piperidines; Rats; Reverse Transcriptase Polymerase Chain Reaction; Stress, Psychological; Terfenadine | 2013 |
Orthogonal projection to latent structures combined with artificial neural networks in non-destructive analysis of ebastine powder.
Topics: Butyrophenones; Neural Networks, Computer; Piperidines; Powders; Spectrophotometry, Infrared | 2014 |
Case report of cold-weather-induced radiation recall dermatitis after chemoradiotherapy with cisplatin.
Topics: Aged; Antineoplastic Agents; Butyrophenones; Carcinoma, Squamous Cell; Chemoradiotherapy; Cisplatin; Cold Temperature; Drug Therapy, Combination; Female; Humans; Methylprednisolone; Nasopharyngeal Neoplasms; Neoplasm Staging; Piperidines; Radiodermatitis | 2014 |
[Hyposensitizing and antioxidative pharmacotherapy of the cyst-like structures in the maxillary sinuses].
Topics: Adolescent; Adult; Antioxidants; Butyrophenones; Cysts; Drug Therapy, Combination; Female; Histamine H1 Antagonists; Humans; Male; Maxillary Sinus; Maxillary Sinusitis; Middle Aged; Picolines; Piperidines; Rhinitis, Allergic; Treatment Outcome; Young Adult | 2014 |
A novel UV degradation product of Ebastine: isolation and characterization using Q-TOF, NMR, IR and computational chemistry.
Topics: Butyrophenones; Chromatography, High Pressure Liquid; Mass Spectrometry; Piperidines; Spectroscopy, Fourier Transform Infrared; Ultraviolet Rays | 2015 |
A New Marmoset P450 4F12 Enzyme Expressed in Small Intestines and Livers Efficiently Metabolizes Antihistaminic Drug Ebastine.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Animals; Butyrophenones; Callithrix; Cytochrome P-450 Enzyme System; Female; Histamine Antagonists; Humans; Hydroxylation; Intestine, Small; Liver; Macaca fascicularis; Male; Microsomes, Liver; Middle Aged; Piperidines; Sequence Alignment; Species Specificity; Substrate Specificity; Young Adult | 2016 |
Simultaneous Liquid Chromatographic Determination of Ebastine with Two Sympathomimetic Drugs Using a Monolithic Column.
Topics: Butyrophenones; Chromatography, Reverse-Phase; Limit of Detection; Linear Models; Piperidines; Reproducibility of Results; Sympathomimetics | 2017 |
Development and validation of probe drug cocktails for the characterization of CYP450-mediated metabolism by human heart microsomes.
Topics: Bupropion; Butyrophenones; Carbamates; Chlorzoxazone; Cytochrome P-450 Enzyme System; Drug Evaluation, Preclinical; Ethanolamines; Humans; Lauric Acids; Microsomes; Midazolam; Myocardium; Oxazines; Piperidines; Tolbutamide | 2019 |
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
Topics: Antineoplastic Agents, Phytogenic; Astemizole; Butyrophenones; Cell Proliferation; Chalcones; Chromatography, Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Forkhead Box Protein O3; Hep G2 Cells; Humans; Microsomes, Liver; Molecular Docking Simulation; Piperidines; Resorcinols; Tandem Mass Spectrometry | 2018 |
Role of Arginine 117 in Substrate Recognition by Human Cytochrome P450 2J2.
Topics: Arginine; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Humans; Hydrogen Bonding; Hydroxylation; Molecular Docking Simulation; Molecular Structure; Mutation; Piperidines; Protein Conformation; Substrate Specificity | 2018 |
Extracellular Signal-Regulated Kinase Mediates Ebastine-Induced Human Follicle Dermal Papilla Cell Proliferation.
Topics: Alopecia; Apoptosis; Butyrophenones; Cell Line; Cell Proliferation; Dermis; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Hair; Hair Follicle; Humans; Mitogen-Activated Protein Kinase 3; Piperidines; Proto-Oncogene Proteins c-akt | 2019 |
Ebastine during pregnancy and lactation in a patient with chronic urticaria: ebastine and carebastine levels in maternal serum, cord blood, breast milk and the infant's serum.
Topics: Animals; Butyrophenones; Chronic Urticaria; Female; Fetal Blood; Histamine H1 Antagonists; Humans; Infant; Lactation; Milk, Human; Piperidines; Pregnancy | 2020 |
Analysis of available surface area can predict the long-term dissolution profile of tablets using short-term stability studies.
Topics: Butyrophenones; Chemistry, Pharmaceutical; Drug Liberation; Drug Stability; Drug Storage; Humidity; Nonlinear Dynamics; Piperidines; Solubility; Tablets; Temperature; Time Factors | 2020 |
Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
Topics: Arachidonic Acid; Astemizole; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Docking Simulation; Oxidation-Reduction; Piperidines; Protein Binding; Substrate Specificity | 2020 |
Improvement of solubility and dissolution of ebastine by fabricating phosphatidylcholine/ bile salt bilosomes.
Topics: Administration, Oral; Bile Acids and Salts; Biological Availability; Butyrophenones; Drug Compounding; Drug Liberation; Histamine H1 Antagonists; Liposomes; Nanoparticles; Phosphatidylcholines; Piperidines; Solubility | 2020 |
Carbopol emulgel loaded with ebastine for urticaria: development, characterization,
Topics: Acrylic Resins; Administration, Cutaneous; Animals; Butyrophenones; Chemistry, Pharmaceutical; Disease Models, Animal; Drug Carriers; Drug Liberation; Drug Stability; Emulsions; Gels; Histamine H1 Antagonists; Hydrogen-Ion Concentration; Male; Piperidines; Rabbits; Rheology; Urticaria; Viscosity | 2022 |
Efficacy and safety of ebastine dose escalation in chronic urticaria: A prospective study.
Topics: Butyrophenones; Cholinergic Agents; Chronic Disease; Chronic Urticaria; Headache; Histamine H1 Antagonists; Humans; Piperidines; Prospective Studies; Sleepiness; Urticaria; Xerostomia | 2022 |
Cytochrome
Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine | 2022 |
Temporary prolongation of the QT interval in acute ebastine intoxication due to challenge video on TikTok in a girl.
Topics: Arrhythmias, Cardiac; Drug Inverse Agonism; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Infant; Long QT Syndrome; Piperidines; Social Media | 2023 |