ebastine and astemizole

ebastine has been researched along with astemizole in 17 studies

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (29.41)18.2507
2000's6 (35.29)29.6817
2010's4 (23.53)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Abou-Gharbia, M; Moyer, JA; Nielsen, ST; Patel, U; Webb, M1
Carrupt, PA; Crivori, P; Cruciani, G; Testa, B1
Nagashima, R; Nishikawa, T; Tobita, M1
Sen, S; Sinha, N1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Brincat, JP; Broccatelli, F; Carosati, E; Cruciani, G; Frosini, M; Kaatz, GW; Neri, A; Sabatini, S1
del Prado, M; Egan, RW; Hey, JA; Kreutner, W1
Peláez, A1
Mattila, MJ; Paakkari, I1
Roberts, DJ1
Górska, M; Grzelewska-Rzymowska, I; Pietrzkowicz, M1
Paakkari, I1
Hirama, T; Matsubara, T; Matsumoto, S; Nagata, K; Yamazoe, Y1
Jeong, HE; Lee, SS; Liu, KH; Moon, T; Oh, SJ; Ryu, JY; Shin, JG; Yoon, CN; Yun, CH1
Jee, JG; Lee, J; Liu, KH; Park, SH; Phuc, NM; Shon, JC1
Chen, LY; Xu, L1
Asano, A; Ijiri, M; Ikenaka, Y; Ishizuka, M; Kawaguchi, H; Mizukawa, H; Murayama, N; Nakayama, SMM; Shiraishi, M; Teraoka, H; Uno, Y; Yamato, O; Yamazaki, H1

Reviews

3 review(s) available for ebastine and astemizole

ArticleYear
Variations among non-sedating antihistamines: are there real differences?
    European journal of clinical pharmacology, 1999, Volume: 55, Issue:2

    Topics: Astemizole; Benzimidazoles; Butyrophenones; Central Nervous System; Cetirizine; Drug Interactions; Heart; Histamine H1 Antagonists; Humans; Hypnotics and Sedatives; Loratadine; Piperidines; Potassium Channel Blockers; Terfenadine; Triprolidine

1999
[The effect of second generation histamine antagonists on the heart].
    Pneumonologia i alergologia polska, 2001, Volume: 69, Issue:3-4

    Topics: Animals; Area Under Curve; Astemizole; Butyrophenones; Electrocardiography; Heart; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Tachycardia; Terfenadine; Torsades de Pointes

2001
Cardiotoxicity of new antihistamines and cisapride.
    Toxicology letters, 2002, Feb-28, Volume: 127, Issue:1-3

    Topics: Arrhythmias, Cardiac; Astemizole; Benzimidazoles; Butyrophenones; Cetirizine; Cisapride; Heart Diseases; Histamine H1 Antagonists; Humans; Loratadine; Piperidines; Serotonin Receptor Agonists; Terfenadine; Triprolidine

2002

Trials

1 trial(s) available for ebastine and astemizole

ArticleYear
Clinical efficacy of ebastine in the treatment and prevention of seasonal allergic rhinitis.
    Drugs, 1996, Volume: 52 Suppl 1

    Topics: Astemizole; Butyrophenones; Double-Blind Method; Histamine H1 Antagonists; Humans; Piperidines; Rhinitis, Allergic, Seasonal; Seasons

1996

Other Studies

13 other study(ies) available for ebastine and astemizole

ArticleYear
New antihistamines: substituted piperazine and piperidine derivatives as novel H1-antagonists.
    Journal of medicinal chemistry, 1995, Sep-29, Volume: 38, Issue:20

    Topics: Animals; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Male; Motor Activity; Piperazines; Piperidines; Rats; Structure-Activity Relationship

1995
Predicting blood-brain barrier permeation from three-dimensional molecular structure.
    Journal of medicinal chemistry, 2000, Jun-01, Volume: 43, Issue:11

    Topics: Blood-Brain Barrier; Databases, Factual; Models, Chemical; Molecular Conformation; Multivariate Analysis; Permeability; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors.
    Bioorganic & medicinal chemistry letters, 2005, Jun-02, Volume: 15, Issue:11

    Topics: Animals; CHO Cells; Cricetinae; Discriminant Analysis; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Potassium Channel Blockers; Potassium Channels, Voltage-Gated

2005
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Ligand Promiscuity between the Efflux Pumps Human P-Glycoprotein and S. aureus NorA.
    ACS medicinal chemistry letters, 2012, Mar-08, Volume: 3, Issue:3

    Topics:

2012
Terfenadine, astemizole, and ebastine produce QTc interval prolongation in an experimental model predictive of adverse clinical ECG effects.
    Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 1996, Volume: 76, Issue:5

    Topics: Animals; Astemizole; Butyrophenones; Electrocardiography; Guinea Pigs; Histamine H1 Antagonists; Models, Biological; Piperidines; Terfenadine

1996
Cardiotoxicity of second-generation antihistamines.
    Drugs, 1999, Volume: 57, Issue:6

    Topics: Astemizole; Butyrophenones; Heart Diseases; Histamine H1 Antagonists; Humans; Piperidines; Terfenadine

1999
Involvement of CYP2J2 on the intestinal first-pass metabolism of antihistamine drug, astemizole.
    Drug metabolism and disposition: the biological fate of chemicals, 2002, Volume: 30, Issue:11

    Topics: Animals; Antibodies, Blocking; Arachidonic Acid; Astemizole; Blotting, Western; Butyrophenones; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Cloning, Molecular; COS Cells; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dealkylation; DNA, Complementary; Enzyme Inhibitors; Gene Library; Histamine H1 Antagonists; Humans; In Vitro Techniques; Intestinal Mucosa; Mass Spectrometry; Microsomes, Liver; Oxygenases; Piperidines; Rabbits; Recombinant Proteins

2002
Identification and functional characterization of novel CYP2J2 variants: G312R variant causes loss of enzyme catalytic activity.
    Pharmacogenetics and genomics, 2005, Volume: 15, Issue:2

    Topics: Alleles; Animals; Astemizole; Butyrophenones; Catalysis; Cell Line; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; DNA Primers; Dose-Response Relationship, Drug; Gene Frequency; Genetic Variation; Heterozygote; Histamine H1 Antagonists; Humans; Insecta; Kinetics; Korea; Methylation; Models, Molecular; Mutation; Oxygenases; Piperidines; Polymerase Chain Reaction; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Recombinant Proteins; Recombination, Genetic; Sequence Analysis, DNA; Time Factors

2005
The inhibitory potential of Broussochalcone A for the human cytochrome P450 2J2 isoform and its anti-cancer effects via FOXO3 activation.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2018, Mar-15, Volume: 42

    Topics: Antineoplastic Agents, Phytogenic; Astemizole; Butyrophenones; Cell Proliferation; Chalcones; Chromatography, Liquid; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Forkhead Box Protein O3; Hep G2 Cells; Humans; Microsomes, Liver; Molecular Docking Simulation; Piperidines; Resorcinols; Tandem Mass Spectrometry

2018
Molecular determinant of substrate binding and specificity of cytochrome P450 2J2.
    Scientific reports, 2020, 12-17, Volume: 10, Issue:1

    Topics: Arachidonic Acid; Astemizole; Butyrophenones; Catalytic Domain; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Hydrophobic and Hydrophilic Interactions; Kinetics; Molecular Docking Simulation; Oxidation-Reduction; Piperidines; Protein Binding; Substrate Specificity

2020
Cytochrome
    Drug metabolism and disposition: the biological fate of chemicals, 2022, Volume: 50, Issue:11

    Topics: Animals; Astemizole; Butyrophenones; Cats; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dogs; Humans; Phylogeny; Piperidines; Swine; Terfenadine

2022