e 64 has been researched along with leucine in 404 studies
| Studies (e 64) | Trials (e 64) | Recent Studies (post-2010) (e 64) | Studies (leucine) | Trials (leucine) | Recent Studies (post-2010) (leucine) |
|---|---|---|---|---|---|
| 477 | 1 | 103 | 28,515 | 744 | 4,178 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 50 (12.38) | 18.7374 |
| 1990's | 148 (36.63) | 18.2507 |
| 2000's | 111 (27.48) | 29.6817 |
| 2010's | 89 (22.03) | 24.3611 |
| 2020's | 6 (1.49) | 2.80 |
| Authors | Studies |
|---|---|
| Isobe, N; Kaneko, H; Nakatsuka, I; Saito, K; Yamada, H; Yoshitake, A | 1 |
| Hara, M; Inagaki, C; Omori, K; Otani, H; Zeng, XT | 1 |
| Davies, P; Jani, JP; Lazo, JS; Mistry, JS; Morris, G; Sebti, SM | 1 |
| Jani, JP; Lazo, JS; Mistry, JS; Morris, G; Sebti, SM | 2 |
| Azuma, M; David, LL; Kadoya, K; Lampi, KJ; Shearer, TR | 1 |
| Azuma, M; David, LL; Shearer, TR | 3 |
| Gatermann, S; Marre, R; Sloot, N; Thomas, M | 1 |
| Balduyck, M; Degand, P; Demeyer, D; Duquesnoy, B; Flipo, RM; Huet, G; Richet, C; Thiebaut, C | 1 |
| Bisiau, H; Degand, P; Demeyer, D; Han, KK; Huet, G; Richet, C; Soudan, B; Tetaert, D | 1 |
| Cromwell, D; Hasnain, S; Su, Y; Varughese, KI; Xuong, NH | 1 |
| Inoue, M; Ishida, T; Kitamura, K; Murata, M; Sumiya, S; Tamai, M; Yamamoto, A; Yokoo, C; Yoneda, T | 1 |
| Choudhuri, S; Klaassen, CD; McKim, JM | 1 |
| Knops, J; Lieberburg, I; Sinha, S | 1 |
| Gorelik, E; Jani, JP; Lazo, JS; Mistry, JS; Sebti, SM | 1 |
| Barrett, AJ; Buttle, DJ; Saklatvala, J; Tamai, M | 1 |
| Droller, MJ; Hodge, DE; Liu, BC; Redwood, SM; Weiss, RE | 1 |
| Hartz, PA; Wilson, PD | 1 |
| Azuma, M; David, LL; Murachi, T; Shearer, TR | 1 |
| Béliveau, R; Gingras, D; Ménard, P | 1 |
| Knutson, VP | 1 |
| Hayes, DJ; McBride, JD; Stubberfield, CR; Wilson, DL | 1 |
| Hecker, M; Kaw, S; Sessa, WC; Vane, JR | 1 |
| Dott, K; Geist, M; Guy, B; Kieny, MP; Lecocq, JP; Spehner, D | 1 |
| Hanada, K; Hatayama, K; Katunuma, N; Miyashita, S; Murata, M; Nikawa, T; Tamai, M; Towatari, T; Yokoo, C | 1 |
| Hanada, K; Katunuma, N; Murata, M; Nikawa, T; Tamai, M; Towatari, T; Yokoo, C | 1 |
| Baines, D; Daston, GP; Lehman-McKeeman, LD; Yonker, JE | 1 |
| Brunk, UT; Marzabadi, MR; Sohal, RS | 1 |
| Shimizu, H | 1 |
| Denek, L; Heidland, A; Schaefer, RM; Schwegler, JS | 1 |
| Doherty, FJ; Laszlo, L; Mayer, RJ; Osborn, NU | 1 |
| Tachikura, T | 1 |
| Inoue, M; Ishida, T; Kitamura, K; Ohishi, H; Sumiya, S; Yamamoto, D | 1 |
| Brunk, UT; Olsson, GM; Zdolsek, JM | 1 |
| Kunze, H; Löffler, BM; Schmidt, M | 1 |
| Eto, Y; Matsui, K; Shirasawa, N | 1 |
| el-Saleh, SC; Hong, H; Johnson, P | 1 |
| Kasuga, N; Umazume, Y | 1 |
| Cazzulo Franke, MC; Cazzulo, JJ; Franke de Cazzulo, BM; Martínez, J | 1 |
| Fukusen, N; Katunuma, N; Kido, H | 1 |
| Mason, RW | 1 |
| Nishimura, C; Nishimura, T; Suzuki, H; Tanaka, N | 1 |
| Lasek, RJ; Sahenk, Z | 1 |
| Nishimura, C; Nishimura, T; Suzuki, H; Tanaka, N; Yamaguchi, H | 1 |
| Eto, Y; Ida, H; Matsui, K | 1 |
| Agapito, MT; Garcia-Herrero, I; Recio, JM; Rodriguez-Cabello, JC | 1 |
| Chen, SF | 1 |
| Doherty, FJ; Landon, M; Laszlo, L; Lennox, G; Lowe, J; Mayer, RJ | 1 |
| Berlet, HH; Ilzenhöfer, H | 1 |
| Doherty, FJ; Laszlo, L; Mayer, RJ; Osborn, NU; Wassell, JA | 1 |
| Decker, RS; Ferguson, AG; Lesch, M; Samarel, AM | 1 |
| Inoue, M; Ishida, T; Kitamura, K; Matsumoto, K; Sumiya, S; Yamamoto, D | 1 |
| Kurita, Y; Nakao, H; Ogawa, H; Takamori, K; Tsuboi, R | 1 |
| Mazda, T; Ogasawara, K | 1 |
| Katunuma, N | 1 |
| Ahmed, FR; Carey, PR; Hasnain, S; Huber, CP; Storer, AC; Varughese, KI | 1 |
| Barrett, AJ; Buttle, DJ; Rawlings, ND; Ritonja, A; Rowan, AD; Turk, V | 1 |
| Alfieri, SC; Rabinovitch, M; Shaw, E; Zilberfarb, V | 1 |
| Hreniuk, D; Lenard, J; Wilson, PD | 1 |
| Kimura, H; Yoshida, K | 1 |
| Barrett, AJ; Kembhavi, AA; Parkes, C | 1 |
| Hanada, K; Koyama, I; Matsumoto, K; Omura, S; Ozawa, Y; Tamai, M | 1 |
| Aikawa, M; Leech, JH; McKerrow, JH; Nagasawa, H; Rosenthal, PJ | 1 |
| Ito, M; Katunuma, N; Kominami, E; Kuroda, Y; Miyao, M; Naito, E; Takeda, E; Toshima, K | 1 |
| Iizuka, H; Iwasaki, Y; Konno, H; Yamamoto, H; Yamamoto, T | 1 |
| Eilon, G; Mascardo, RN | 1 |
| Beertsen, W; Everts, V; Schröder, R | 1 |
| Huntley, JF; Knox, DP | 1 |
| Baricos, WH; Cortez, SL; O'Connor, SE; Shah, SV; Wu, LT | 1 |
| Fujino, Y; Masuda, K; Minoda, K; Mochizuki, M; Nakamura, M | 1 |
| Dahlmann, B; Reinauer, H; Rutschmann, M | 1 |
| Hosoya, J; Inazuki, K; Komatsu, K; Satoh, S | 1 |
| Beertsen, W; Everts, V; Tigchelaar-Gutter, W | 1 |
| Hashida, S; Katunuma, N; Kominami, E; Takio, K; Titani, K; Towatari, T | 1 |
| Ogata, K; Oyanagi, M; Tsurugi, K | 1 |
| Amaya, N; Miyatake, T; Sato, S; Yanagisawa, K | 1 |
| Miyatake, T; Sato, S; Yanagisawa, K | 1 |
| Ishiura, S; Suzuki, K; Tsuji, S | 1 |
| Suzuki, K | 1 |
| Katsunuma, N; Kominami, E; Miyatake, T; Sato, S; Yanagisawa, K | 1 |
| Amamoto, T; Hanada, K; Komurasaki, T; Okazaki, T; Omura, S | 2 |
| Grinde, B | 1 |
| Barrett, AJ; Hanada, K; Kembhavi, AA | 1 |
| Barrett, AJ; Brown, MA; Hanada, K; Kembhavi, AA; Kirschke, H; Knight, CG; Tamai, M | 1 |
| Hashida, S; Katunuma, N; Kominami, E | 2 |
| Adachi, T; Hanada, K; Kashiwagi, K; Oguma, K; Ohzeki, M; Omura, S; Tamai, M | 1 |
| Hashida, S; Katunuma, N; Kominami, E; Towatari, T | 1 |
| Długosz, JW; Korsten, MA | 1 |
| Horii, I; Koyama, J; Nomura, J; Suzuki, Y | 1 |
| Ebisui, C; Fujita, J; Ishidoh, K; Kominami, E; Monden, M; Morimoto, T; Ogawa, A; Shiozaki, H; Tsujinaka, T; Yano, M | 1 |
| Brorson, JR; Marcuccilli, CJ; Miller, RJ | 1 |
| Li, E; Stanley, SL; Yang, WG; Zhang, T | 1 |
| Balba, Y; Donnelly, PV; Knutson, VP; Lopez-Reyes, M | 1 |
| Jones, JB; Martichonok, V; Ménard, R; Plouffe, C; Storer, AC | 1 |
| Auclair, M; Dubertret, L; Franchi, J; Gardette, J; Mazière, C; Mazière, JC; Quiec, D; Redziniak, G; Santus, R | 1 |
| Debari, K; Rifkin, BR; Sasaki, T; Udagawa, N | 1 |
| Kakegawa, H; Katunuma, N; Kawata, T; Ohba, Y; Sumitani, K; Tagami, K | 1 |
| Katunuma, N; Kominami, E | 1 |
| Bradley, C; Henriquez, DA; Pance, A; Perez, N | 1 |
| Cho, SY; Chung, YB; Joo, IJ; Kang, SY; Kong, Y | 1 |
| Bode, W; Huber, R; Katunuma, N; Podobnik, M; Popovic, T; Turk, D; Turk, V | 1 |
| Fliszar, CJ; Gluck, SL; Schmid, TM; Sires, UI; Wang, ZQ; Welgus, HG | 1 |
| Fujiwara, M; Hironaka, K; Sorimachi, Y; Yoshida, K | 1 |
| Atsma, DE; Bastiaanse, EM; Jerzewski, A; Van der Laarse, A; Van der Valk, LJ | 1 |
| Fox, T; Mason, P; Mort, JS; Storer, AC | 1 |
| Alfieri, SC; Oliveira Júnior, OC; Pral, EM; Stolf, AM; Yokoyama-Yasunaka, JK | 1 |
| David, LL; Iwasaki, N; Shearer, TR | 1 |
| Berg, K; Moan, J | 2 |
| Rosenthal, PJ | 1 |
| Coombs, GH; North, MJ; Scott, DA | 1 |
| Duncan, R; Kunz-Jenkins, C; Li, E; Stanley, SL; Stenson, WF; Swanson, PE | 1 |
| Brocklehurst, K; Shah, HN; Sreedharan, SK | 1 |
| Grimaldi Júnior, G; Leon, LL; Soares, MJ; Temporal, RM | 1 |
| Asano, G; Shimizu, Y; Win, T | 1 |
| Claeys, E; Demeyer, D; Uytterhaegen, L | 1 |
| Kishore, BK; Maldague, P; Montenez, JP; Tulkens, PM | 1 |
| Iizuka, K | 1 |
| Gour-Salin, BJ; Lachance, P; Magny, MC; Ménard, R; Plouffe, C; Storer, AC | 1 |
| Kelsall, BL; Ravdin, JI | 1 |
| Homma, Y; Ikeuchi, Y; Kim, K; Suzuki, A | 1 |
| Azuma, M; David, LL; Kadoya, K; Shearer, TR | 1 |
| Kobayashi, H; Moniwa, N; Ohi, H; Shinohara, H; Sugimura, M; Terao, T | 1 |
| Brunk, U; Roberg, K; Zdolsek, J; Zhang, H | 1 |
| Boyer, MJ; Firestone, RA; Horn, I; Steele-Norwood, D; Tannock, IF | 1 |
| Gour-Salin, BJ; Lachance, P; Ménard, R; Plouffe, C; Storer, AC | 1 |
| Barrett, AJ; Buttle, DJ; Kembhavi, AA; Knight, CG | 1 |
| Gamboa de Domínguez, ND; Rosenthal, PJ | 1 |
| Budnik, A; Grewe, M; Gyufko, K; Krutmann, J | 1 |
| Brocklehurst, K; Brocklehurst, SM; Caves, LS; Gharbia, SE; Shah, HN; Sreedharan, SK; Verma, C | 1 |
| Schnellmann, RG; Yang, X | 1 |
| Coulombe, R; Cygler, M; Grochulski, P; Mort, JS; Sivaraman, J; Storer, AC | 1 |
| Hayama, T; Kobori, T; Kondo, K; Ohba, Y; Sigeizumi, S; Sugimoto, K; Sumitani, K; Tagami, K; Tsuji, T; Woo, JT; Yamaguchi, K | 1 |
| Averna, M; Melloni, E; Michetti, M; Minafra, R; Pontremoli, S; Salamino, F; Tedesco, I | 1 |
| Goodenough, PW; Katerelos, NA; Pickersgill, RW; Scott, M; Taylor, MA | 1 |
| Antoku, S; Aramaki, R; Cai, Y; Zhu, WG | 1 |
| Cummings, NJ; Groves, MR; Jenkins, JA; Pickersgill, RW; Scott, M; Taylor, MA | 1 |
| Chan, SL; Feng, MH; Huber, CP; Lim, C; Xiang, Y | 1 |
| Liu, X; McCarron, RC; Nordin, JH | 1 |
| Hall, DJ; Palmenberg, AC | 1 |
| Forney, JR; Healey, MC; Yang, S | 1 |
| Banerjee, D; Francis, SE; Gluzman, IY; Goldberg, DE; Oksman, A | 1 |
| Abdel-Meguid, SS; Amegadzie, BY; D'Alessio, K; Griffin, C; Hanning, CR; Janson, CA; Jones, C; Kurdyla, J; McQueney, M; Qiu, X; Smith, WW; Zhao, B | 1 |
| Brodt, P; Mort, JS; Navab, R | 1 |
| Ferger, D; Krieglstein, J; Rami, A | 1 |
| Ebert, W; Jülke, B; Lah, T; Spiess, E; Werle, B | 1 |
| Kalbus, M; Long, EO; Malnati, M; Martin, R; Pinet, V; Riccio, P; Vergelli, M; Vogt, AB | 1 |
| Fujisawa, Y; Fujishima, A; Imai, Y; Nomura, T; Sugawara, T; Yamamoto, Y | 1 |
| Curtis, MA; Rangarajan, M; Smith, SJ; U, S | 1 |
| Baer, GS; Dermody, TS | 1 |
| Kamchonwongpaisan, S; Meshnick, SR; Samoff, E | 1 |
| Donovan, EA; Hofbauer, B; Saluja, AK; Steer, ML; Yamaguchi, Y; Yamanaka, K | 1 |
| Abe, K; Himeno, M; Moroi, R; Nishimura, Y; Nishiura, T; Tanaka, T; Terada, Y; Yamaza, T | 1 |
| Azuma, M; David, LL; Fukiage, C; Shearer, TR | 1 |
| Cyrino, FZ; Juliano, L; Scharfstein, J; Svensjö, E | 1 |
| Afonso, S; Babiarz, B; Romagnano, L | 1 |
| Curtis, PV; Franch, HA; Mitch, WE | 1 |
| Ghosh, SK; Samuelson, J | 1 |
| Cantley, LG; Kjelsberg, CA; Nigam, SK; Sakurai, H; Tsukamoto, T | 1 |
| Assfalg-Machleidt, I; Machleidt, W; Moroder, L; Schaschke, N; Turk, D | 1 |
| Erra-Pujada, M; Gripon, JC; Mata, L; Mistou, MY | 1 |
| Agapito, MT; Gutierrez-Baraja, R; Pablos, M; Recio, JM; Reiter, RJ | 1 |
| Furui, T; Hatano, S; Kaino, M; Kaino, S; Nakamura, K; Okita, K | 1 |
| Vanyushin, BF; Vlasova, TI | 1 |
| Chai, JY; Choi, MH; Lee, SH; Park, WJ; Park, YK | 1 |
| Eng, K; Galloway, AC; Marcus, SG; Mignatti, P; Monea, S; Patel, S; Schwartz, JD; Shamamian, P | 1 |
| Galloway, AC; Marcus, SG; Mignatti, P; Monea, S; Schwartz, JD; Shamamian, P; Whiting, D | 1 |
| Beertsen, W; Delaissé, JM; Everts, V; Korper, W | 1 |
| Beyer, EC; Green, K; Laing, JG; Saffitz, JE; Tadros, PN | 1 |
| Beavis, RC; Berman, Y; Devi, LA; Newcomb, EW; Reed, JC; Thomas, A; Wood, DE | 1 |
| Cloutier, C; Overney, S; Yelle, S | 1 |
| Hasselgren, PO; Luo, GJ; Wang, JJ; Wang, L | 1 |
| Bray, PG; Mungthin, M; Ridley, RG; Ward, SA | 1 |
| Brocklehurst, K; Brown, A; Chambers, L; Kalsheker, NA; Pritchard, DI; Sreedharan, S | 1 |
| Govrin, E; Levine, A | 1 |
| Homma, K; Natori, S; Yamaguchi, S | 1 |
| Fujimori, K; Inui, T; Ishibashi, O; Kokubo, T; Nakajima, M; Origane, Y | 1 |
| Auten, KJ; Fowlkes, JL; Kumar, S; Rosenberg, CK; Thrailkill, KM | 1 |
| Huber, CP; Ishida, T; Kitamura, K; Matsumoto, K; Mizoue, K; Tse, WC | 1 |
| Beertsen, W; Docherty, AJ; Everts, V; Heera, S; Jansen, DC; Korper, W; Lammerse, I; Steinfort, J | 1 |
| Devi, LA; Liuzzo, JP; Moscatelli, D; Petanceska, SS | 1 |
| Ancolio, K; Checler, F; da Costa, CA | 1 |
| Azuma, M; Fukiage, C; Nakamura, Y; Shearer, TR | 1 |
| Billingsley, PF; Nisbet, AJ | 1 |
| Matsukura, A; Otani, T | 1 |
| Guay, J; Mancini, JA; Riendeau, D | 1 |
| Azuma-Hara, M; Niinobe, M; Taniura, H; Uetsuki, T; Yoshikawa, K | 1 |
| Atkinson, HJ; Brain, P; Glen, DM; Shewry, PR; Urwin, PE; Walker, AJ | 1 |
| Cigic, B; Pain, RH | 1 |
| Knap, AK; Peppard, JV | 1 |
| Berman-Frank, I; Hadas, O; Kaplan, A; Levine, A; Rozenberg, T; Vardi, A | 1 |
| Asuru, A; Boudjelal, M; Fisher, GJ; Kang, S; Li, XY; Peng, ZH; Voorhees, JJ; Xiao, JH | 1 |
| Johnson, S; Knox, A | 1 |
| Brondello, JM; McKenzie, FR; Pouysségur, J | 1 |
| Ikata, T; Ikebe, M; Ikeda, Y; Mishiro, T; Nakano, S; Yasuoka, S | 1 |
| Fagard, R; Lijnen, P; Petrov, V | 1 |
| Arteaga, C; Castañera, P; Lombardero, M; Pernas, M; Salcedo, G; Sanchez-Monge, R; Sanchez-Ramos, I | 1 |
| Bartels, K; Cebulski, K; Kekow, J; Kühne, C; Zielinski, S | 1 |
| Berg, K; Kirveliene, V; Sandvig, K; Selbo, PK | 1 |
| Brzin, J; Elden, TC; Smigocki, AC; Wilhite, SE | 1 |
| Bogyo, M; Burlingame, A; Greenbaum, D; Medzihradszky, KF | 1 |
| Bird, AC; Okubo, A; Sameshima, M; Uehara, F; Unoki, K | 1 |
| Cooper, BS; Garrett, WM; Guthrie, HD | 1 |
| Harada, M; Okuno, S; Sakakibara, H; Suzuki, T; Yano, T | 1 |
| Goldberg, DE; Oksman, A; Salmon, BL | 1 |
| Baer, GS; Brumbaugh, DE; Chance, SR; Dermody, TS; Ebert, DH; Stobie, LE; Wetzel, JD | 1 |
| Authier, F; Bergeron, JJ; Brodt, P; Chevet, E; Di Guglielmo, GM; Navab, R | 1 |
| Inui, T; Ishibashi, O; Kokubo, T; Kumegawa, M; Kurokawa, T; Mori, Y | 1 |
| Hayashi, Y; Inoue, H; Kizu, Y; Mizuno, F; Ono, M; Saito, I; Takada, K; Tsubota, K; Yamada, K; Yanagi, K | 1 |
| Justesen, J; Martensen, PM | 1 |
| Drake, JL; Smith, HJ; Tisdale, MJ; Whitehouse, AS | 1 |
| Baldwin, KM; Ikemoto, M; Izumi, R; Kishi, K; Kitano, T; Nikawa, T; Nonaka, I; Rokutan, K; Takeda, S; Teshima, S; Towatari, T; Watanabe, C | 1 |
| Katunuma, N; Kito, M; Moriyama, T; Ogawa, T; Simoni, RD; Urade, R; Wada, M | 1 |
| Chiba, T; Itoh, Y; Kajita, M; Kinoh, H; Mori, H; Okada, A; Seiki, M | 1 |
| Baruch, A; Bogyo, M; Gilula, NB; Greenbaum, D; Kumar, NM; Levy, ET; Nielsen, PA | 1 |
| Radhika, G; Sarin, A; Varghese, J | 1 |
| Dinh, DH; Gondi, CS; Gujrati, M; Konduri, S; Lakka, SS; Olivero, WC; Rao, JS; Tasiou, A; Yanamandra, N | 1 |
| Alvarez-Hernandez, AD; Lachance, P; Ménard, R; Qo, H; Roush, WR; Sulea, T; Therrien, C | 1 |
| Bland, FA; Bond, A; Fearn, S; Harris, SJ; Kaleta, J; Layton, GT; Lee, SR; Ward, G; Wood, ML | 1 |
| Baravick, E; Baravick, J; Coyne, CP; Fenwick, BW; Howell, T; Willetto, C | 1 |
| Eyal, O; Jadoun, J; Sela, S | 1 |
| Ariatta, C; Castino, R; Démoz, M; Gargiulo, M; Isidoro, C; Pace, D; Raiteri, E | 1 |
| Goto, T; Maeda, H; Tanaka, T | 1 |
| Chauhan, SS; Chhikara, P; Datta Gupta, S; Mahajan, VS | 1 |
| Dixon, MS; Golstein, C; Jones, JD; Krüger, J; Mulder, L; Smoker, M; Tang, S; Thomas, CM | 1 |
| Rosenthal, PJ; Semenov, AV; Shenai, BR | 1 |
| Belkhiri, A; Bourget, L; Guilbault, C; Lytvyn, V; Massie, B; Ménard, R; Nägler, DK | 1 |
| Barnes, PJ; Culpitt, SV; Demattos, C; Dodd, S; Donnelly, LE; Fitzgerald, M; Russell, RE; Thorley, A | 1 |
| Bucheli, P; Gysler, C; Laloi, M; McCarthy, J; Morandi, O | 1 |
| Barrett, C; Cathers, BE; Palmer, JT; Rydzewski, RM | 1 |
| Beers, M; Brasch, F; Bühling, F; Guttentag, S; Robinson, L; Zhang, P | 1 |
| Debari, K; Itoh, K; Sahara, T; Sasaki, T | 1 |
| Chuang, WJ; Jeng, A; Kansal, RG; Kotb, M; Nizet, V | 1 |
| Applebaum, SW; Birk, Y; Hanzon, J; Mattoo, AK; Smirnoff, P | 1 |
| Kim, JH; Mullin, CA | 1 |
| Ikeda, T | 1 |
| Kita, K; Nomura, J; Sugaya, S; Suzuki, N; Takahashi, S; Zhang, HC | 1 |
| Bosserhoff, A; Dennhöfer, R; Hunzelmann, N; Klose, A; Krieg, T; Kurschat, P; Mauch, C; van Muijen, G; Zigrino, P | 1 |
| Bogyo, M; Brömme, D; Dolenc, I; Fonović, M; Kopitar-Jerala, N; Puizdar, V; Rozman-Pungercar, J; Stefe, I; Trstenjak-Prebanda, M; Turk, B; Turk, D; Turk, V; Vandenabeele, P; Vasiljeva, O | 1 |
| Beis, I; Gaitanaki, C; Papazafiri, P | 1 |
| Arancio, O; Battaglia, F; Liu, S; Nixon, RA; Trinchese, F; Walter, S | 1 |
| Kita, H; Park, HY; Seoh, JY; Shin, MH | 1 |
| Borgonio, V; Fernández, AM; Garrido, E; Molinari, JL; Sepúlveda, J; Solano, S; Tato, P | 1 |
| Cloutier, C; Michaud, D; Rivard, D | 1 |
| Kawano, Y; Kobae, H; Miyata, K; Sameshima, K; Yamamoto, K; Yoshidome, K | 1 |
| Campbell, RL; Davies, PL; Diaz, BG; Kuiper, MJ; Moldoveanu, T | 1 |
| Moroder, L; Schaschke, N; Stern, I; Turk, D | 1 |
| Grubb, A; Holmdahl, M; Holmdahl, R | 1 |
| Horta, MF; Ramalho-Pinto, FJ; Silva-Jardim, I | 1 |
| García de León, MC; González-Canto, A; López-Vancell, R; Montfort, I; Nequiz-Avendaño, M; Olivos-García, A; Pérez-Tamayo, R; Tello, E | 1 |
| Naik, S; Naik, SR; Singh, D | 1 |
| Drew, ME; Gluzman, IY; Goldberg, DE; Liu, J | 1 |
| Fujisaki, K; Islam, KM; Kamio, T; Miyoshi, T; Tsuji, N | 1 |
| Kusaka, K; Mayama, S; Nakayashiki, H; Sakamoto, M; Shigemi, T; Tada, Y; Tosa, Y | 1 |
| Irvine, AE; Lynas, J; Magill, L; Morris, TC; Walker, B | 1 |
| Dos Santos, AL; Soares, RM | 1 |
| Coppi, A; Hutter, C; Pinzon-Ortiz, C; Sinnis, P | 1 |
| Chammaa, S; Sánchez-Ruiz, A; Sarabia, F | 1 |
| Behnke, JM; Buttle, DJ; Duce, IR; Lowe, A; Stepek, G | 1 |
| Brown, PA; Chatterjee, PK; Cuzzocrea, S; Mazzon, E; Mota-Filipe, H; Sivarajah, A; Stewart, KN; Thiemermann, C; Todorovic, Z | 1 |
| Ebihara, T; Hattori, S; Irie, S; Matsubara, Y; Miura-Yokota, Y | 1 |
| de Wit, PJ; Jones, JD; Joosten, MH; Rooney, HC; van der Hoorn, RA; Van't Klooster, JW | 1 |
| Golouh, R; Jeras, M; Kos, J; Langerholc, T; Premzl, A; Repnik, U; Sekirnik, A; Turk, B; Turk, V; Werle, B; Zavasnik Bergant, V | 1 |
| Alcalá-Canto, Y; Gracia-Mora, J; Ibarra-Velarde, F; Sumano-López, H | 1 |
| Lau, AL; McKerrow, JH; Pandey, KC; Rosenthal, PJ; Sijwali, PS; Wang, SX | 1 |
| Knowles, PP; Masino, L; McDonald, NQ; Menon, RP; Nicastro, G; Pastore, A | 1 |
| Authier, F; Briand, G; Kouach, M | 1 |
| Hu, ZH; Sheng, XY | 1 |
| Jiang, W; Johnson, GD | 1 |
| Alviano, CS; Branquinha, MH; d'Avila-Levy, CM; Dias, FA; Elias, CG; Lopes, AH; Pereira, FM; Ribeiro, RO; Santos, AL; Soares, RM; Souto-Padrón, T | 1 |
| Chung, YB; Kim, JY; Kim, KS; Yang, HJ | 1 |
| Alcaide-Hidalgo, JM; de Boer, AR; Irth, H; Kolkman, J; Krabbe, JG; Lingeman, H; Niessen, WM; van Emde Boas, CN | 1 |
| Alberti-Navarro, A; Alcalá-Canto, Y; Gracia-Mora, J; Ibarra-Velarde, F; Sumano-Lopez, H | 1 |
| Bustos, P; Concha, C; Genevière, AM; Imschenetzky, M; Iribarren, C; Morin, V; Puchi, M; Quiñones, K | 1 |
| Aguirre-Guzmán, G; Ascencio, F; Saulnier, D | 1 |
| Bae, YA; Cho, SY; Kang, I; Kim, SH; Kim, TS; Kong, Y; Lee, EG; Na, BK; Sohn, WM; Yu, JR | 1 |
| Celis-Guerrero, L; García-Carreño, F; López, MD; Navarrete del Toro, Mde L; Saborowski, R | 1 |
| Akiba, H; Hatanaka, H; Ichikawa, S; Ikeda, S; Kato, T; Kikuchi, Y; Kuhara, T; Mitsuishi, K; Ogawa, H; Okumura, K; Ota, M; Takai, T; Tokura, T | 1 |
| Lixin, X; Muleke, CI; Ruofeng, Y; Xiangrui, L; Yanming, S | 1 |
| Ashmarina, L; Bifsha, P; Chemtob, S; Durand, S; Gravel, RA; Landry, K; Pshezhetsky, AV; Quiniou, C; Seyrantepe, V; Sladek, R; Trudel, S; Xu, Y | 1 |
| de A Lima, AP; Fukuma, T; Grab, DJ; Kim, YV; Lonsdale-Eccles, JD; Nikolskaia, OV; Scharfstein, J | 1 |
| Montfort, I; Nequiz, M; Olivos García, A; Ramos, E; Tello, E | 1 |
| Alhassan, A; Govind, Y; Igarashi, I; Okubo, K; Yokoyama, N | 1 |
| Sawada, H; Yokota, N | 1 |
| Behnke, JM; Buttle, DJ; Clark, SJ; Curtis, RH; Duce, IR; Kerry, BR; Lowe, AE; Shewry, PR; Stepek, G | 1 |
| Lamas, J; Leiro, J; Paramá, A; Piazzon, MC; Sanmartín, ML | 1 |
| Duan, JJ; Huesing, J; Teixeira, D | 1 |
| Ahn, SJ; Chung, JK; Hong, YK; Jang, JH; Jeon, SJ; Kim, KH; Kim, MS; Kim, NY; Lee, HH; Seo, JS | 1 |
| Conlon, JM; Ishizuka, Y; Iwata, T; Kato, T; Kikuyama, S; Nakada, T; Toyoda, F | 1 |
| Jin, X; Leng, Y; Ray, P; Ray, R | 1 |
| Behrendt, JH; Hermosilla, C; Taubert, A; Zahner, H | 1 |
| Gunawan, H; Ikeda, S; Ogawa, H; Okumura, K; Takai, T | 1 |
| Banerjee, R; Drew, ME; Gilbertson, S; Goldberg, DE; Rosenthal, PJ; Uffman, EW | 1 |
| Cunningham, S; Quinn, DJ; Scott, CJ; Walker, B | 1 |
| Branquinha, MH; d'Avila-Levy, CM; Dias, FA; Elias, CG; Lopes, AH; Pereira, FM; Santos, AL; Silva, TL | 1 |
| Gu, Y; Han, J; Jia, W; Li, G; Luo, M; Luo, T | 1 |
| Fujikado, T; Hara, T; He, L; Ito, M; Iwata, T; Kasai, H; Kin, T; Kumamoto, T; Tanabe, F | 1 |
| Kim, YS; Kwon, HJ; Lee, HK | 1 |
| Katoh, R; Miyata, M; Nakamura, Y; Nakao, A; Ogawa, H; Ohnuma, Y; Okumura, K; Shimokawa, N | 1 |
| Atwa, MM; Dawoud, HA; Hussein, EM; Salem, AM | 1 |
| Lübbert, H; Schulten, R; Stichel, CC; Wendt, W | 1 |
| Dutra, PM; Elias, CG; Lima, AK; Santos, AL; Souza, JE | 1 |
| Gomes, MT; Lopes, MT; Salas, CE; Turchetti, AP | 1 |
| Alves, CR; Côrte-Real, S; Côrtes, LM; d'Avila-Levy, CM; Finkelstein, LC; Pascarelli, BM; Pereira, BA; Pinho, RT; Rebello, KM | 1 |
| Dutta, S; Ghosh, AS; Raha, S | 1 |
| Khan, S; Sharma, S; Verma, G | 1 |
| Brábek, J; Folk, P; Mierke, CT; Panková, D; Rösel, D; Tolde, O; Vesely, P | 1 |
| Balboula, AZ; Hegab, AO; Sakatani, M; Takahashi, M; Yamanaka, K; Zaabel, SM | 2 |
| Chettri, JK; Leibowitz, MP; Ofir, R; Zilberg, D | 1 |
| Hu, Y; Itoh, Y; Morioka, K | 1 |
| Chun, J; Nagai, J; Uchida, H; Ueda, H; Ueda, M; Xie, W | 1 |
| Dziegiel, MH; Henriksen, K; Karsdal, MA; Kocijancic, D; Leeming, DJ; Neutzsky-Wulff, AV; Sørensen, MG | 1 |
| Hayakawa, T; Kawase, N; Kishi, J; Nakamura, H | 1 |
| Inagaki, S; Ishihara, K; Miyamoto, M; Potempa, J; Shaw, LN; Wawrzonek, K | 1 |
| Albuquerque, MG; Alves, CR; Bourguignon, SC; Castro, HC; Cavalcanti, DF; da Silva, FC; da Silva, GG; de Pinho, RT; de Souza, AM; Ferreira, VF; Rodrigues, CR; Santos, DO | 1 |
| Alamir, I; Aziz, M; Boukhettala, N; Breuillé, D; Coëffier, M; Déchelotte, P | 1 |
| Maemoto, Y; Maki, M; Osako, Y; Shibata, H; Suzuki, H; Tanaka, R | 1 |
| Elpidina, EN; Mazumdar-Leighton, S; Oppert, B; Toutges, M | 1 |
| Engelbrecht, S; Griese, M; Kaltenborn, E; Kern, S | 1 |
| Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM | 1 |
| Antone, JV; Bartlett, JD; Tye, CE | 1 |
| Bartnik, E; Caglič, D; Globisch, A; Jeske, V; Juretschke, HP; Kindermann, M; Lim, NH; Nagase, H; Turk, B; Weithmann, KU; Wendt, KU | 1 |
| Carrilho, MR; Geraldeli, S; Minciotti, CL; Nader, HB; Nascimento, FD; Pashley, DH; Salo, T; Tay, FR; Tersariol, IL; Tjäderhane, L | 1 |
| Gupta, AK; Kumar, R; Kumar, S; Singh, RK; Tatu, U; Yadav, SC | 1 |
| Carlini, CR; Defferrari, MS; Demartini, DR; Marcelino, TB; Pinto, PM | 1 |
| de Azevedo-Pereira, RL; de Carvalho, AC; Goldenberg, RC; Lima, AP; Medei, EH; Mendez-Otero, R; Rodrigues, Dde C; Rondinelli, E | 1 |
| Fukunaga, M; Gon, Y; Hashimoto, S; Inoue, T; Nunomura, S; Ra, C; Yoshioka, M | 1 |
| Gu, Z; Li, C; Song, J; Yang, R | 1 |
| Biswas, S; Choudhury, D; Dattagupta, JK; Dutta, S | 1 |
| Andrade-Gordon, P; Barocelli, E; Cenac, N; Gobbetti, T; Martin, L; Motta, JP; Rolland, C; Steinhoff, M; Vergnolle, N | 1 |
| Bawolak, MT; Gera, L; Marceau, F; Roy, C | 1 |
| Barros, N; Breschi, L; Carmona, AK; Carrilho, MR; Gesteira, TF; Nascimento, FD; Pashley, DH; Scaffa, PM; Tersariol, IL; Tjäderhane, L; Vidal, CM | 1 |
| Campos, RC; Hauser-Davis, RA; Lima, AA; Ziolli, RL | 1 |
| Bäuerl, C; Blaas, PM; Mach, L; Mikula, M; Mikulits, W; Ng, KM; Nimmerfall, E; Puxbaum, V; Taub, N; Wieser, J; Yeoh, GC | 1 |
| Assis, DM; Barbiéri, CL; Caroselli, EE; Gazarini, ML; Júdice, WA; Juliano, L; Juliano, MA | 1 |
| Amin, A; Berger, E; Bilic, I; Hess, M; Nöbauer, K; Patzl, M | 1 |
| Alonso-Villaverde, V; Berger, V; Gindro, K; Godard, S; Schnee, S; Viret, O; Voinesco, F | 1 |
| Agee, KA; Breschi, L; Key, WO; Mazzoni, A; Mutluay, M; Nishitani, Y; Pashley, DH; Scheffel, DL; Seseogullari-Dirihan, R; Tay, FR; Tezvergil-Mutluay, A; Tjäderhane, L | 1 |
| Baldzizhar, R; Czyzyk, J; Fedorchuk, C; Henegariu, O; Jha, M; Rathinam, C | 1 |
| Alvarez-Alfageme, F; Bigler, F; Pálinkás, Z; Romeis, J | 1 |
| Caffini, NO; Errasti, ME; Pelzer, LE; Rotelli, AE | 1 |
| Biswas, S; Dattagupta, JK; Dutta, S | 1 |
| Drakulić, BJ; Gavrović-Jankulović, M; Grozdanović, MM | 1 |
| Arancio, O; Brunsteiner, M; Chandrasena, EP; Fa', M; Litosh, V; Petukhov, P; Schiefer, IT; Scism, R; Siklos, M; Sinha, V; Tapadar, S; Tavassoli, E; Thatcher, GR; Wijewickrama, GT | 1 |
| Balboula, AZ; Hegab, AO; Kawahara, M; Sakatani, M; Takahashi, M; Yamanaka, K; Zaabel, SM | 1 |
| Behnke, JM; Buttle, DJ; De Pomerai, D; Phiri, AM | 1 |
| Gil-Monreal, M; Royuela, M; van der Hoorn, RA; Villamor, JG; Zabalza, A; Zulet, A | 1 |
| Croke, M; Gonzalo, S; Grotsky, DA; Kreienkamp, R; Neumann, MA; Yaddanapudi, SC | 1 |
| Li, YH; Lin, KJ; Liu, YL; Liu, ZW; Peng, YF; Romeis, J; Wang, ZX | 1 |
| Li, Y; Liang, GB; Wu, SY; Yang, WX; Yao, K; Zhang, WH | 1 |
| Ito, M; Nakajima, T; Tanabe, F | 1 |
| Ilyas, M; Ilyas, S; Mathur, S; van der Hoorn, RA | 1 |
| Bae, JH; Chang, KT; Kim, JW; Koo, DB; Lee, YH; Min, SH; Park, SY; Song, BS; Yeon, JY | 1 |
| Fouda, MA; Hammad, KM; Hasaballah, AI; Hassan, MI | 2 |
| Di Tomaso, MV; Folle, GA; Lafon-Hughes, L; Liddle, P; Reyes-Ábalos, AL; Toledo, A | 1 |
| Benouaret, R; Goujon, E; Goupil, P | 1 |
| Aleksic, I; Andjelkovic, U; Gavrovic-Jankulovic, M; Grozdanovic, MM; Ostojic, S; Petersen, A | 1 |
| Rathaur, S; Singh, N; Wadhawan, M | 1 |
| Arafet, K; Ferrer, S; Martí, S; Moliner, V | 1 |
| Hadler-Olsen, E; Hafstad, A; Solli, AI; Uhlin-Hansen, L; Winberg, JO | 1 |
| Cummins, N; Dabo, AJ; Foronjy, RF; Geraghty, P; Taggart, CC; Weldon, S | 1 |
| Chen, B; Li, Y; Liang, G; Liao, W; Wu, S; Yang, W; Yao, K; Zhang, W; Zheng, K | 1 |
| Behnke, JM; Buttle, DJ; Duce, IR; Lowe, A; Luoga, W; Mansur, F | 1 |
| Bychkov, ML; Dolgikh, DA; Gasparian, ME; Kirpichnikov, MP | 1 |
| Bezbradica, JS; Medzhitov, R; Rosenstein, RK; Yu, S | 1 |
| Allanki, AD; Navale, R; Sijwali, PS | 1 |
| Chen, X; Li, Y; Peng, Y; Romeis, J; Yin, X; Zhang, X | 1 |
| Cui, XS; Kim, NH; Kim, SH; Liang, S; Zhao, MH | 1 |
| Cui, J; Jiang, P; Liu, LN; Liu, RD; Qi, X; Wang, ZQ; Zhang, X; Zhang, ZF | 1 |
| Azarkan, M; Baeyens-Volant, D; El Mahyaoui, R; Matagne, A; Wattiez, R | 1 |
| Platt, MO; Porter, KM; Sidell, N; Wieser, FA; Wilder, CL | 1 |
| Fernández, TD; Flores, OM; García, CG; Maya, YC; Monroy, VS; Pérez Ishiwara, DG | 1 |
| Enghild, JJ; Garcia-Ferrer, I; Gomis-Rüth, FX; Guevara, T; Lukassen, MV; Meinjohanns, E; Nielsen, TA; Risør, MW; Rossen, L; Sanggaard, KW; Scavenius, C; Thomsen, LR; Thøgersen, IB | 1 |
| Cai, JP; Cui, JM; Fu, BQ; Jia, WZ; Li, WH; Ma, XT; Qu, ZG; Yue, L; Zhang, NZ | 1 |
| Autenrieth, IB; Beifuss, B; Bender, A; Frick, JS; Kalbacher, H; Maurer, A; Müller, R; Schäfer, A; Steimle, A | 1 |
| Evans, G; Kershaw, CM; Maxwell, WMC; Rodney, R | 1 |
| Chen, F; Jia, J; Li, J; Song, Y; Yin, P; Zhang, Y | 1 |
| Johnson, J; Odero-Marah, V; Payne, CK; Peyton, SR; Platt, MO; Stewart, FAA; Walton, C; Watson, V; Wilder, CL | 1 |
| Blass, G; Ilatovskaya, DV; Levchenko, V; Staruschenko, A | 1 |
| Apolonio, F; Breschi, L; Carrilho, MR; Curci, R; Gobbi, P; Mazzoni, A; Nascimento, FD; Pashley, D; Scaffa, PM; Tersariol, IL; Tjäderhane, L; Vidal, CM | 1 |
| Abrahamson, M; Grubb, A; Kasprzykowski, F; Kassem, A; Lerner, UH; Lindholm, C; Strålberg, F | 1 |
| Ferguson, C; Gomez, GA; Huston, WM; Kerr, MC; Murphy, JM; Parton, RG; Tanzer, MC; Teasdale, RD; Yap, AS | 1 |
| Wilkesman, J | 1 |
| Hosseini, SM; Nasr-Esfahani, MH; Ostadhosseini, S; Pezhman, M; Rouhollahi Varnosfaderani, S; Sefid, F | 1 |
| Caljon, G; Cos, P; De Schryver, M; Delputte, PL; Heykers, A; Leemans, A; Maes, L; Van der Gucht, W | 1 |
| Akhter, M; Dixit, R; Katyal, A; Mishra, PK; Pandey, KC; Rathi, B; Saxena, AK; Sharma, R; Singh, AP; Singh, J | 1 |
| Balboula, AZ; Egashira, J; Khatun, H; Sakatani, M; Takahashi, M; Takenouchi, N; Tatemoto, H; Wada, Y; Yamanaka, KI | 1 |
| Bergbower, EAS; Boinot, C; Cebotaru, L; Guggino, WB; Liu, Q; Sabirzhanova, I; Yanda, MK | 1 |
| Campbell, RL; Davies, PL; McCartney, CE; Ye, Q | 1 |
| Bashir, R; Cvetkovic, C; Ferrall-Fairbanks, MC; Grant, L; Hadley, P; Ko, E; Pagan-Diaz, GJ; Platt, MO; Raman, R | 1 |
| Alves, CR; Cysne-Finkelstein, L; de Albuquerque-Melo, BC; de Castro Côrtes, LM; de Oliveira Junior, FOR; Pereira, BAS; Pereira, MCS; Ribeiro-Guimarães, ML; Santos-de-Souza, R; Silva-Almeida, M; Souza-Silva, F | 1 |
| Aboelenain, M; Bai, H; Balboula, AZ; Fujii, T; Kawahara, M; Li, J; Moriyasu, S; Takahashi, M | 1 |
| Meng, X; Shi, Y; Song, C; Wu, D; Zhang, L | 1 |
| Fujimuro, M; Hosokawa, K; Ishimaru, H; Sugimoto, A; Tanaka, R; Watanabe, T | 1 |
| Arafa, FM; Elkerdany, ED; Elnassery, SM; Mady, RF; Zaki, SA | 1 |
| Azarkan, M; Calvo Esposito, R; Charlier, P; Delbrassine, F; Herman, R; Kerff, F; M'Rabet, N; Maquoi, E | 1 |
| Aboelenain, M; Bai, H; Balboula, AZ; Hegab, AEO; Kawahara, M; Sakatani, M; Shirozu, T; Takahashi, M; Yamanaka, KI; Zaabel, SM | 1 |
3 review(s) available for e 64 and leucine
| Article | Year |
|---|---|
Ubiquitin-protein conjugates: clinical and experimental findings.
Topics: Cell Compartmentation; Cysteine Proteinase Inhibitors; Humans; Intermediate Filaments; Leucine; Lysosomes; Metabolism, Inborn Errors; Organelles; Proteins; Ubiquitins | 1989 |
Mechanisms and regulation of lysosomal proteolysis.
Topics: Amino Acid Sequence; Animals; Autophagy; Base Sequence; Cathepsins; Cell Compartmentation; Cycloheximide; Cystatins; Gene Expression Regulation; Humans; Leucine; Lysosomes; Molecular Sequence Data; Muscular Diseases; Proteins; Restriction Mapping | 1989 |
Cysteine Protease Zymography: Brief Review.
Topics: Animals; Cathepsins; Cysteine Proteases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme Assays; Humans; Hydrogen-Ion Concentration; Leucine; Protein Denaturation; Reducing Agents | 2017 |
1 trial(s) available for e 64 and leucine
| Article | Year |
|---|---|
Treatment development for systemic Tetrahymena sp. infection in guppies, Poecilia reticulata Peters.
Topics: Animals; Anti-Bacterial Agents; Antiparasitic Agents; Cells, Cultured; Ciliophora Infections; Cysteine Proteinase Inhibitors; Fish Diseases; Leucine; Poecilia; Tetrahymena | 2010 |
400 other study(ies) available for e 64 and leucine
| Article | Year |
|---|---|
Differences in alpha 2u-globulins increased in male rat kidneys following treatment with several alpha 2u-globulin accumulating agents: cystein protease(s) play(s) an important role in production of kidney-type-alpha 2u-globulin.
Topics: Alpha-Globulins; Animals; Chlorobenzenes; Cyclohexanones; Cyclohexenes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Kidney; Leucine; Leupeptins; Limonene; Male; Naphthalenes; Octanes; Rats; Rats, Sprague-Dawley; Terpenes | 1992 |
Different patterns of protein kinase C redistribution mediated by alpha 1-adrenoceptor stimulation and phorbol ester in rat isolated left ventricular papillary muscle.
Topics: Adrenergic alpha-Agonists; Animals; Leucine; Leupeptins; Male; Myocardial Contraction; Papillary Muscles; Phenylephrine; Phorbol 12,13-Dibutyrate; Protease Inhibitors; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha | 1992 |
In vivo circumvention of human colon carcinoma resistance to bleomycin.
Topics: Animals; Bleomycin; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Drug Interactions; Drug Resistance; Female; Humans; Leucine; Lung; Mice; Mice, Inbred C57BL; Mice, Nude; Neoplasm Transplantation; Pulmonary Fibrosis; Sensitivity and Specificity; Tissue Distribution; Transplantation, Heterologous | 1992 |
In vivo sensitization of human lung carcinoma to bleomycin by the cysteine proteinase inhibitor E-64.
Topics: Animals; Bleomycin; Cell Line; Cysteine Proteinase Inhibitors; Drug Administration Schedule; Drug Resistance; Female; Humans; Leucine; Lung Neoplasms; Mice; Mice, Nude; Neoplasm Transplantation; Time Factors; Transplantation, Heterologous; Tumor Cells, Cultured | 1992 |
Comparison of cell-permeable calpain inhibitors and E64 in reduction of cataract in cultured rat lenses.
Topics: Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Cell Membrane Permeability; Chromatography, High Pressure Liquid; Culture Techniques; Cysteine Proteinase Inhibitors; Dipeptides; Drug Interactions; Electrophoresis, Polyacrylamide Gel; Glycoproteins; Lens, Crystalline; Leucine; Leupeptins; Molecular Sequence Data; Rats; Rats, Sprague-Dawley | 1992 |
Superior prevention of calcium ionophore cataract by E64d.
Topics: Animals; Calcimycin; Calcium; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Lens, Crystalline; Leucine; Organ Culture Techniques; Organ Size; Rats; Rats, Sprague-Dawley | 1992 |
Purification and characterisation of elastase from Staphylococcus epidermidis.
Topics: Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Fibrinogen; Fibronectins; Hydrogen-Ion Concentration; Immunoglobulins; Leucine; Pancreatic Elastase; Serum Albumin; Staphylococcus epidermidis; Temperature | 1992 |
Measurement of elastase and cysteine proteinases in synovial fluid of patients with rheumatoid arthritis, sero-negative spondylarthropathies, and osteoarthritis.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Amino Acid Sequence; Arthritis, Rheumatoid; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Female; Humans; Leucine; Male; Middle Aged; Molecular Sequence Data; Osteoarthritis; Pancreatic Elastase; Spinal Diseases; Substrate Specificity; Synovial Fluid | 1992 |
Characterization of different proteolytic activities in Trypanosoma brucei brucei.
Topics: Amino Acid Sequence; Animals; Chromatography, Affinity; Chromatography, High Pressure Liquid; Dithiothreitol; Endopeptidases; Glycoproteins; Hydrogen-Ion Concentration; Kinetics; Leucine; Leupeptins; Molecular Sequence Data; Protease Inhibitors; Trypanosoma brucei brucei | 1992 |
Crystal structure of an actinidin-E-64 complex.
Topics: Binding Sites; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrons; Leucine; Molecular Conformation; X-Ray Diffraction | 1992 |
Molecular design of potent inhibitor specific for cathepsin B based on the tertiary structure prediction.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cathepsin B; Chromatography, Thin Layer; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Leucine; Models, Molecular; Molecular Sequence Data; Papain; Rats; X-Ray Diffraction | 1992 |
Hydration and elevated calcium alone do not produce xylose nuclear cataract: role of proteolysis by calpain.
Topics: Animals; Calcium; Calpain; Cataract; Cysteine Proteinase Inhibitors; Lens, Crystalline; Leucine; Organ Culture Techniques; Rats; Rats, Inbred Strains; Xylose | 1992 |
Role of hepatic lysosomes in the degradation of metallothionein.
Topics: Animals; Cathepsins; Electrophoresis, Polyacrylamide Gel; Leucine; Leupeptins; Liver; Lysosomes; Male; Metallothionein; Pepstatins; Rats; Rats, Inbred Strains | 1992 |
Evidence for a nonsecretory, acidic degradation pathway for amyloid precursor protein in 293 cells. Identification of a novel, 22-kDa, beta-peptide-containing intermediate.
Topics: Amyloid beta-Protein Precursor; Cell Line; Chloroquine; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Leupeptins; Molecular Weight; Peptide Fragments; Transfection | 1992 |
Metabolic inactivation: a mechanism of human tumor resistance to bleomycin.
Topics: Animals; Bleomycin; Burkitt Lymphoma; Carcinoma, Squamous Cell; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Damage; Drug Resistance; Glycoside Hydrolases; Head and Neck Neoplasms; Humans; Inactivation, Metabolic; Leucine; Mice; Mice, Nude; Neoplasm Transplantation; Tumor Cells, Cultured | 1991 |
Cysteine proteinase inhibitors and bleomycin-sensitive and -resistant cells.
Topics: Bleomycin; Carcinoma, Squamous Cell; Cell Division; Cell Survival; Cysteine Proteinase Inhibitors; Drug Resistance; Drug Synergism; Head and Neck Neoplasms; Leucine; Leupeptins; Tumor Cells, Cultured | 1991 |
Inhibition of interleukin 1-stimulated cartilage proteoglycan degradation by a lipophilic inactivator of cysteine endopeptidases.
Topics: Animals; Cartilage; Cattle; Cysteine Proteinase Inhibitors; Interleukin-1; Iodoacetates; Iodoacetic Acid; Leucine; Proteoglycans; Recombinant Proteins | 1992 |
Abrogation of the invasion of human bladder tumor cells by using protease inhibitor(s).
Topics: Animals; Carcinoma, Transitional Cell; Cell Movement; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Humans; Laminin; Leucine; Mice; Mice, Nude; Neoplasm Invasiveness; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1992 |
Mechanisms of cyclosporine A toxicity in defined cultures of renal tubule epithelia: a role for cysteine proteases.
Topics: Animals; Calcium; Cell Death; Cells, Cultured; Cyclosporine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diltiazem; Dose-Response Relationship, Drug; Epithelial Cells; Epithelium; Humans; Kidney Diseases; Kidney Tubules; Leucine; Microscopy, Fluorescence; Nifedipine; Rabbits; Time Factors; Verapamil | 1991 |
Amelioration of cataracts and proteolysis in cultured lenses by cysteine protease inhibitor E64.
Topics: Animals; Calcimycin; Calpain; Cataract; Chromatography, High Pressure Liquid; Crystallins; Culture Techniques; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Lens, Crystalline; Leucine; Rats; Rats, Inbred Strains; Selenium; Sodium Selenite; Xylose | 1991 |
Protein carboxyl methylation in kidney brush-border membranes.
Topics: Animals; Cell Membrane; Cytosol; Electrophoresis, Polyacrylamide Gel; Gelatin; Hydrogen-Ion Concentration; Kidney Cortex; Kinetics; Leucine; Male; Methylation; Microvilli; Oligopeptides; Ovalbumin; Protein O-Methyltransferase; Rats; Rats, Inbred Strains; S-Adenosylmethionine | 1991 |
Proteolytic processing of the insulin receptor beta subunit is associated with insulin-induced receptor down-regulation.
Topics: Animals; Blotting, Western; Cells, Cultured; Chloroquine; Cycloheximide; Cysteine Endopeptidases; Down-Regulation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Insulin; Insulin Antagonists; Leucine; Leupeptins; Mice; Peptide Fragments; Receptor, Insulin | 1991 |
Alterations in cysteine proteinase content of rat lung associated with development of Pneumocystis carinii infection.
Topics: Animals; Body Weight; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Isoelectric Focusing; Leucine; Lung; Male; Pneumocystis; Pneumonia, Pneumocystis; Rats; Rats, Inbred Strains; Time Factors; Trimethoprim, Sulfamethoxazole Drug Combination | 1991 |
Cysteine protease inhibitor E64 reduces the rate of formation of selenite cataract in the whole animal.
Topics: Animals; Body Water; Calcium; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Disease Models, Animal; Electrophoresis, Polyacrylamide Gel; Immunoblotting; Injections, Intraperitoneal; Lens, Crystalline; Leucine; Organ Culture Techniques; Rats; Rats, Inbred Strains; Selenious Acid; Selenium | 1991 |
The biosynthesis of endothelin-1 by human polymorphonuclear leukocytes.
Topics: Animals; Endothelins; Glycopeptides; Humans; In Vitro Techniques; Jugular Veins; Kinetics; Leucine; Muscle, Smooth, Vascular; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Pepstatins; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Rabbits | 1991 |
A specific inhibitor of cysteine proteases impairs a Vif-dependent modification of human immunodeficiency virus type 1 Env protein.
Topics: Amino Acid Sequence; Animals; Antiviral Agents; Base Sequence; Blotting, Western; Cell Line; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Escherichia coli; Gene Products, vif; Genes, vif; Genes, Viral; HIV-1; Leucine; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligonucleotide Probes; Sequence Homology, Nucleic Acid; Transfection; vif Gene Products, Human Immunodeficiency Virus; Viral Envelope Proteins | 1991 |
Novel epoxysuccinyl peptides. Selective inhibitors of cathepsin B, in vitro.
Topics: Animals; Calpain; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Dipeptides; Endopeptidases; In Vitro Techniques; Leucine; Liver; Rats | 1991 |
Novel epoxysuccinyl peptides. A selective inhibitor of cathepsin B, in vivo.
Topics: Animals; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Chromatography, High Pressure Liquid; Cysteine Endopeptidases; Dipeptides; Endopeptidases; Enzyme Activation; Kinetics; Leucine; Rats; Rats, Inbred Strains | 1991 |
Effects of lysosomal proteinase inhibition on the development of the rat embryo in vitro.
Topics: Animals; Cathepsins; Cysteine Proteinase Inhibitors; Embryonic and Fetal Development; Ethylmaleimide; Extracellular Space; Leucine; Leupeptins; Lysosomes; Organ Culture Techniques; Osmolar Concentration; Pepstatins; Rats; Rats, Inbred Strains; Yolk Sac | 1991 |
Mechanisms of lipofuscinogenesis: effect of the inhibition of lysosomal proteinases and lipases under varying concentrations of ambient oxygen in cultured rat neonatal myocardial cells.
Topics: Animals; Animals, Newborn; Cathepsins; Cells, Cultured; Cysteine Proteinase Inhibitors; Heart; Kinetics; Leucine; Leupeptins; Lipofuscin; Lysosomes; Microscopy, Electron; Myocardium; Netilmicin; Oxygen; Phospholipases; Rats | 1991 |
Different resorption modes on living and devitalized bones by isolated osteoclasts in vitro. The effects of TIMP, E-64, and TGF-alpha.
Topics: Animals; Bone Resorption; Cysteine Proteinase Inhibitors; Disease Models, Animal; Female; Glycoproteins; Indomethacin; Leucine; Metalloendopeptidases; Mice; Microscopy, Electron, Scanning; Osteoclasts; Prostaglandins; Rabbits; Tissue Inhibitor of Metalloproteinases; Transforming Growth Factor alpha | 1990 |
Parathyroid hormone increases thiol proteinase activity by activation of protein kinase C in cultured kidney tubule cells (OK).
Topics: Animals; Calcimycin; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; In Vitro Techniques; Kidney Tubules; Leucine; Opossums; Parathyroid Hormone; Peptide Hydrolases; Protein Kinase C; Tetradecanoylphorbol Acetate | 1990 |
Ubiquitinated protein conjugates are specifically enriched in the lysosomal system of fibroblasts.
Topics: Cell Line; Cysteine Proteinase Inhibitors; Fibroblasts; Immunohistochemistry; L-Lactate Dehydrogenase; Leucine; Lysosomes; Microscopy, Electron; Proteins; RNA, Messenger; Ubiquitins | 1990 |
The teratogenic effects of E-64 on rat embryogenesis.
Topics: Abnormalities, Drug-Induced; Animals; Cysteine Proteinase Inhibitors; Female; Fetus; Leucine; Pregnancy; Rats; Rats, Inbred Strains | 1990 |
Molecular dynamics simulation of papain-E-64 (N-[N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl]agmatine) complex.
Topics: Computer Simulation; Leucine; Molecular Conformation; Molecular Structure; Papain; Stereoisomerism; Thermodynamics | 1990 |
Photooxidative damage to lysosomes of cultured macrophages by acridine orange.
Topics: Acridine Orange; Animals; Cell Survival; Cells, Cultured; Cysteine Proteinase Inhibitors; Fluorescence; Leucine; Light; Lysosomes; Macrophages; Mice; Microscopy, Electron; Microscopy, Electron, Scanning; Oxidation-Reduction | 1990 |
Protease inhibitors reduce lysosomal acid phospholipase A1 activity in cultured rat hepatocytes.
Topics: Animals; Cells, Cultured; Chymotrypsin; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Liver; Lysosomes; Oligopeptides; Pepstatins; Phospholipases; Phospholipases A; Phospholipases A1; Protease Inhibitors; Rats; Time Factors | 1990 |
Cytoplasmic accumulations in rat primary brain cell cultures following treatment with E-64, a thiol protease inhibitor.
Topics: Animals; Cells, Cultured; Cysteine Endopeptidases; Cytoplasmic Granules; Enzyme Inhibitors; Leucine; Meninges; Microscopy, Electron; Rats; Rats, Inbred Strains | 1990 |
Fluorescence spectroscopic analysis of calpain II interactions with calcium and calmodulin antagonists.
Topics: Binding Sites; Calcium; Calmodulin; Calpain; Felodipine; Fluorescent Dyes; Imidazoles; In Vitro Techniques; Leucine; Molecular Conformation; Naphthalenesulfonates; Spectrometry, Fluorescence | 1990 |
Deterioration induced by physiological concentration of calcium ions in skinned muscle fibres.
Topics: Animals; Antipain; Calcium; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Iodoacetates; Iodoacetic Acid; Leucine; Leupeptins; Microscopy, Electron; Muscle Contraction; Muscles; Rana catesbeiana; Temperature | 1990 |
Some kinetic properties of a cysteine proteinase (cruzipain) from Trypanosoma cruzi.
Topics: Amino Acid Sequence; Animals; Binding Sites; Caseins; Chromogenic Compounds; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Sequence Data; Protozoan Proteins; Substrate Specificity; Trypanosoma cruzi | 1990 |
Antibody and inhibitor of chymase inhibit histamine release in immunoglobulin E-activated mast cells.
Topics: alpha 1-Antichymotrypsin; Animals; Aprotinin; Chymotrypsin; Histamine Release; Immunoglobulin E; Immunoglobulin Fab Fragments; Leucine; Leupeptins; Mast Cells; Oligopeptides; p-Methoxy-N-methylphenethylamine; Rats; Rats, Inbred Strains | 1985 |
Species variants of cathepsin L and their immunological identification.
Topics: Animals; Cathepsin L; Cathepsins; Cattle; Coumarins; Cysteine Endopeptidases; Diazomethane; Dipeptides; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Epitopes; Humans; Immunoelectrophoresis; Isoenzymes; Kinetics; Leucine; Protease Inhibitors; Rabbits; Rats; Sheep; Species Specificity | 1986 |
Potentiation of the cytotoxicity of peplomycin against Ehrlich ascites carcinoma by bleomycin hydrolase inhibitors.
Topics: Animals; Bleomycin; Carcinoma, Ehrlich Tumor; Cell Survival; Cysteine Endopeptidases; Drug Synergism; Female; Glycoside Hydrolases; Leucine; Leupeptins; Mice; Oligopeptides; Peplomycin | 1987 |
Inhibition of proteolysis blocks anterograde-retrograde conversion of axonally transported vesicles.
Topics: Animals; Axonal Transport; Axons; Leucine; Leupeptins; Male; Microscopy, Electron; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Reference Values; Sciatic Nerve | 1988 |
Inhibition of intracellular bleomycin hydrolase activity by E-64 leads to the potentiation of the cytotoxicity of peplomycin against Chinese hamster lung cells.
Topics: Animals; Bleomycin; Cell Survival; Cells, Cultured; Cricetinae; Cricetulus; Cysteine Endopeptidases; Drug Synergism; Glycoside Hydrolases; Leucine; Lung; Peplomycin; Protease Inhibitors | 1989 |
[Application of neuronal cell culture in human degenerative brain disorders].
Topics: Age Factors; Animals; Cathepsin H; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Disease Models, Animal; Humans; Leucine; Leukodystrophy, Globoid Cell; Mice; Neuronal Ceroid-Lipofuscinoses; Neurons; Oligodendroglia; Psychosine; Rats | 1989 |
Effects of EGTA and calmodulin, neutral thiol proteinases and protein kinase C inhibitors on loss of chicken pineal serotonin N-acetyltransferase activity.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Acetyltransferases; Animals; Arylamine N-Acetyltransferase; Calmodulin; Chickens; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Egtazic Acid; Isoquinolines; Leucine; Pineal Gland; Piperazines; Protein Kinase C; Protein Kinase Inhibitors | 1989 |
Teratogenic effects of combined use of anti-kidney serum and E-64 in the rat.
Topics: Animals; Cysteine Proteinase Inhibitors; Drug Synergism; Female; Immune Sera; Leucine; Pregnancy; Rats; Rats, Inbred Strains; Teratogens | 1989 |
Elucidation of cathepsin B-like activity associated with extracts of human myelin basic protein.
Topics: 4-Chloromercuribenzenesulfonate; Cathepsin B; Cathepsins; Dithioerythritol; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Humans; Hydrogen-Ion Concentration; Leucine; Leupeptins; Myelin Basic Protein; Protease Inhibitors | 1985 |
Insoluble disulfide cross-linked polypeptides accumulate in the functionally compromised lysosomes of fibroblasts treated with the cysteine protease inhibitor E-64.
Topics: Animals; Cells, Cultured; Cross-Linking Reagents; Cysteine Proteinase Inhibitors; Kinetics; Leucine; Lysosomes; Mice; Microscopy, Electron; Molecular Weight; Peptides; Proteins | 1989 |
Effects of cysteine protease inhibitors on rabbit cathepsin D maturation.
Topics: Animals; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Proteinase Inhibitors; Fibroblasts; Kinetics; Leucine; Leupeptins; Methionine; Myocardium; Protein Processing, Post-Translational; Rabbits; Sulfur Radioisotopes | 1989 |
Crystal structure and molecular conformation of E-64, a cysteine protease inhibitor.
Topics: Crystallization; Cysteine Proteinase Inhibitors; Leucine; Protein Conformation; X-Ray Diffraction | 1989 |
Differences in induction of lysosomal protease activity by protease inhibitors in B16 melanoma cell lines.
Topics: Acid Phosphatase; Animals; Cathepsin B; Enzyme Induction; Leucine; Leupeptins; Melanoma, Experimental; Mice; Oligopeptides; Pepstatins; Peptide Hydrolases; Protease Inhibitors; Subcellular Fractions; Tumor Cells, Cultured | 1989 |
Differences in substrate specificities for cysteine proteinases used in blood group serology, and the use of bromelain in a two-phase inhibitor technique.
Topics: Albumins; Blood Grouping and Crossmatching; Bromelains; Caseins; Cysteine Endopeptidases; Evaluation Studies as Topic; Ficain; Immunoenzyme Techniques; Leucine; Papain; Substrate Specificity | 1989 |
Crystal structure of a papain-E-64 complex.
Topics: Crystallization; Hydrogen Bonding; Leucine; Papain; Protease Inhibitors; Spectrometry, Fluorescence | 1989 |
Stem bromelain: amino acid sequence and implications for weak binding of cystatin.
Topics: Amino Acid Sequence; Binding Sites; Bromelains; Cathepsin H; Cathepsin L; Cathepsins; Cyanogen Bromide; Cystatins; Cysteine Endopeptidases; Endopeptidases; Fruit; Humans; Leucine; Molecular Sequence Data; Molecular Structure; Papain; Peptide Fragments; Plants; Protease Inhibitors; Proteins; Sequence Homology, Nucleic Acid; Structure-Activity Relationship | 1989 |
Leishmania amazonensis: involvement of cysteine proteinases in the killing of isolated amastigotes by L-leucine methyl ester.
Topics: Animals; Cysteine Endopeptidases; Diazomethane; Electrophoresis, Polyacrylamide Gel; Leishmania mexicana; Leucine; Macrophages; Mice; Protease Inhibitors; Substrate Specificity | 1989 |
Reduced cytotoxicity of the lysosomotropic detergent N-dodecylimidazole after differentiation of HL60 promyelocytes.
Topics: Cathepsins; Cell Differentiation; Cell Line; Cell Survival; Granulocytes; Humans; Imidazoles; Leucine; Leukemia, Myeloid, Acute; Lysosomes; Macrophages | 1989 |
Effect of calcium on protein composition of human platelet cytoskeletons.
Topics: Adenosine Triphosphatases; Blood Platelets; Calcium; Cysteine Endopeptidases; Cytoskeletal Proteins; Cytoskeleton; Humans; Leucine; Polyethylene Glycols; Protease Inhibitors | 1985 |
Calpain inhibition by peptide epoxides.
Topics: Animals; Binding Sites; Calpain; Chickens; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Epoxy Compounds; Ethers, Cyclic; Glycoproteins; Kinetics; Leucine; Peptides; Protease Inhibitors | 1985 |
In vitro and in vivo inhibition of cysteine proteinases by EST, a new analog of E-64.
Topics: Animals; Calpain; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Intestinal Absorption; Leucine; Male; Protease Inhibitors; Rats; Rats, Inbred Strains | 1986 |
A malarial cysteine proteinase is necessary for hemoglobin degradation by Plasmodium falciparum.
Topics: Animals; Cysteine Endopeptidases; Hemoglobins; Leucine; Leupeptins; Malaria; Microscopy, Electron; Molecular Weight; Plasmodium falciparum; Protease Inhibitors | 1988 |
Involvement of thiol proteases in galactosialidosis.
Topics: beta-Galactosidase; Cathepsin B; Cathepsin H; Cathepsins; Cells, Cultured; Coumarins; Cysteine Endopeptidases; Diazomethane; Dipeptides; Endopeptidases; Fibroblasts; Galactosidases; Humans; Leucine; Leupeptins; Neuraminidase; Protease Inhibitors | 1986 |
Suppression of neurofilament degradation by protease inhibitors in experimental spinal cord injury.
Topics: Animals; Electrophoresis, Polyacrylamide Gel; Intermediate Filament Proteins; Leucine; Leupeptins; Male; Nerve Tissue Proteins; Neurofilament Proteins; Oligopeptides; Protease Inhibitors; Rats; Rats, Inbred Strains; Spinal Cord; Spinal Cord Injuries | 1987 |
The cysteine protease inhibitor, E-64, stimulates the polarization and locomotor responses of endothelial cells to wounding.
Topics: Animals; Calcimycin; Calcium; Calmodulin; Cattle; Cell Movement; Cells, Cultured; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Activation; Leucine; Microscopy, Fluorescence; Microscopy, Phase-Contrast; Protein Kinase C | 1988 |
Effects of the proteinase inhibitors leupeptin and E-64 on osteoclastic bone resorption.
Topics: Animals; Bone Resorption; Cells, Cultured; Leucine; Leupeptins; Mice; Oligopeptides; Osteoclasts; Protease Inhibitors | 1988 |
Classification of sheep abomasal mucosal mast cell proteinase as a serine endopeptidase (EC 3.4.21).
Topics: Abomasum; Animals; Chymotrypsin; Dithiothreitol; Isoflurophate; Leucine; Mast Cells; Mucous Membrane; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Proteinase Inhibitors; Sheep | 1988 |
The cysteine proteinase inhibitor, E-64, reduces proteinuria in an experimental model of glomerulonephritis.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Endopeptidases; Glomerulonephritis; Kidney Cortex; Kidney Glomerulus; Leucine; Protease Inhibitors; Proteinuria; Rabbits; Rats | 1988 |
In vivo effects of prostaglandins on human retinoblastoma cells in nude mice.
Topics: Animals; Cell Division; Eye Neoplasms; Humans; Leucine; Mice; Mice, Nude; Neoplasm Transplantation; Prostaglandin D2; Prostaglandins; Prostaglandins D; Retinoblastoma | 1987 |
Effect of starvation or treatment with corticosterone on the amount of easily releasable myofilaments in rat skeletal muscles.
Topics: Actin Cytoskeleton; Animals; Corticosterone; Cytoskeleton; Food; Leucine; Male; Muscles; Organ Size; Protease Inhibitors; Rats; Rats, Inbred Strains; Starvation | 1986 |
Beneficial effect of new thiol protease inhibitors, epoxide derivatives, on dystrophic mice.
Topics: Animals; Body Weight; Creatine Kinase; Leucine; Male; Mice; Mice, Inbred C57BL; Motor Activity; Muscular Dystrophy, Animal | 1986 |
The digestion of phagocytosed collagen is inhibited by the proteinase inhibitors leupeptin and E-64.
Topics: 2,2'-Dipyridyl; Animals; Ascorbic Acid; Bone and Bones; Collagen; Culture Techniques; Cycloheximide; Cytochalasin B; Fibroblasts; Leucine; Leupeptins; Mice; Microscopy, Electron; Oligopeptides; Phagocytosis; Vacuoles | 1985 |
Rat liver thiol proteinases: cathepsin B, cathepsin H and cathepsin L.
Topics: Amino Acid Sequence; Animals; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Epitopes; Leucine; Liver; Lysosomes; Rats; Substrate Specificity | 1981 |
The role of nuclear serine proteases in the degradation of newly synthesized histones and ribosomal proteins.
Topics: Animals; Chromatin; Endopeptidases; Histones; Leucine; Liver; Liver Regeneration; Phenylmethylsulfonyl Fluoride; Rats; Rats, Inbred Strains; Ribosomal Proteins; RNA; Serine Endopeptidases | 1983 |
Degradation of myelin basic protein by calcium-activated neutral protease (CANP) in human brain and inhibition by E-64 analogue.
Topics: Brain; Calpain; Endopeptidases; Humans; Kinetics; Leucine; Myelin Basic Protein; Protease Inhibitors | 1983 |
Conversion of myelin-associated glycoprotein (MAG) to a smaller derivative by calcium activated neutral protease (CANP)-like enzyme in myelin and inhibition by E-64 analogue.
Topics: Calpain; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Humans; Immunosorbent Techniques; In Vitro Techniques; Leucine; Myelin Proteins; Myelin Sheath; Myelin-Associated Glycoprotein; Protease Inhibitors; Spectrophotometry, Atomic | 1984 |
Effect of Ca2+ on the inhibition of calcium-activated neutral protease by leupeptin, antipain and epoxysuccinate derivatives.
Topics: Animals; Antipain; Calcium; Calpain; Cations, Divalent; Chickens; Iodoacetates; Iodoacetic Acid; Kinetics; Leucine; Leupeptins; Muscles; Oligopeptides; Protease Inhibitors | 1981 |
Reaction of calcium-activated neutral protease (CANP) with an epoxysuccinyl derivative (E64c) and iodoacetic acid.
Topics: Animals; Calcium; Calpain; Chickens; Endopeptidases; Iodoacetates; Iodoacetic Acid; Leucine; Muscles; Protein Conformation; Time Factors | 1983 |
Degradation of myelin proteins by cathepsin B and inhibition by E-64 analogue.
Topics: Cathepsin B; Cathepsins; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; In Vitro Techniques; Leucine; Myelin Proteins; Proteolipids | 1984 |
Effect of E-64, a thiol protease inhibitor, on antibody formation in mice.
Topics: Animals; Antibody Formation; Erythrocytes; Female; Leucine; Male; Mice; Mice, Inbred Strains; Protease Inhibitors; Sheep; Structure-Activity Relationship; Time Factors | 1984 |
Effect of E-64, thiol protease inhibitor, on the secondary anti-SRBC response in vitro.
Topics: Animals; Antibody Formation; Cells, Cultured; Concanavalin A; Cyclophosphamide; Erythrocytes; Female; Ficoll; Immunologic Memory; In Vitro Techniques; Kinetics; Leucine; Lymphocyte Activation; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Mitogens; Protease Inhibitors; Sheep; Spleen; Tosyllysine Chloromethyl Ketone | 1984 |
Selective inhibition of lysosomal protein degradation by the thiol proteinase inhibitors E-64, Ep-459 and Ep-457 in isolated rat hepatocytes.
Topics: Animals; Cysteine Endopeptidases; Drug Interactions; Kinetics; Leucine; Leupeptins; Liver; Lysosomes; Male; Propylamines; Protease Inhibitors; Rats; Rats, Inbred Strains | 1982 |
E-64 [L-trans-epoxysuccinyl-leucyl-amido(4-guanidino)butane] and related epoxides as inhibitors of cysteine proteinases.
Topics: Binding Sites; Binding, Competitive; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Epoxy Compounds; Ethers, Cyclic; Leucine; Molecular Conformation; Protease Inhibitors; Structure-Activity Relationship | 1981 |
L-trans-Epoxysuccinyl-leucylamido(4-guanidino)butane (E-64) and its analogues as inhibitors of cysteine proteinases including cathepsins B, H and L.
Topics: Binding Sites; Cathepsin B; Cathepsin H; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Kinetics; Leucine; Models, Biological; Protease Inhibitors; Structure-Activity Relationship | 1982 |
Inhibitions of cathepsin B and cathepsin L by E-64 in vivo. II. Incorporation of [3H]E-64 into rat liver lysosomes in vivo.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; In Vitro Techniques; Leucine; Liver; Lysosomes; Male; Protein Binding; Rats; Rats, Inbred Strains; Subcellular Fractions; Time Factors | 1982 |
Papain inhibitions by optically active E-64 analogs.
Topics: Agmatine; Guanidines; Kinetics; Leucine; Optical Rotation; Papain; Protease Inhibitors; Structure-Activity Relationship | 1981 |
Inhibitions of degradation of rat liver aldolase and lactic dehydrogenase by N-[N-(L-3-trans-carboxyoxirane-2-carbonyl)-L-leucyl] agmatine or leupeptin in vivo.
Topics: Agmatine; Animals; Cathepsins; Fructose-Bisphosphate Aldolase; Guanidines; Kinetics; L-Lactate Dehydrogenase; Leucine; Leupeptins; Liver; Lysosomes; Male; Oligopeptides; Rats | 1980 |
Inhibitions by E-64 derivatives of rat liver cathepsin B and cathepsin L in vitro and in vivo.
Topics: Agmatine; Animals; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Endopeptidases; Guanidines; Kinetics; Leucine; Liver; Lysosomes; Protease Inhibitors; Rats; Stereoisomerism; Structure-Activity Relationship; Sulfhydryl Compounds | 1980 |
Cathepsin B inhibition in two models of acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Cathepsin B; Ceruletide; Disease Models, Animal; Leucine; Lipase; Male; Pancreatitis; Rats; Rats, Sprague-Dawley | 1993 |
The role of proteases in stratum corneum: involvement in stratum corneum desquamation.
Topics: Antipain; Aprotinin; Detergents; Endopeptidases; Epidermis; Ethylmaleimide; Humans; Leucine; Leupeptins; Oligopeptides; Pepstatins; Protease Inhibitors; Sunburn | 1994 |
Autocatalytic inactivation of lysosomal cathepsins is associated with inhibition of protein breakdown by insulin-like growth factor-1 (IGF-1) in myotubes.
Topics: Analysis of Variance; Animals; Blotting, Northern; Cathepsin B; Cathepsin L; Cathepsins; Cell Line; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Gene Expression; Half-Life; Insulin; Insulin-Like Growth Factor I; Leucine; Lysosomes; Mice; Muscle, Skeletal; Protein Biosynthesis; Proteins; Rats; RNA | 1995 |
Delayed antagonism of calpain reduces excitotoxicity in cultured neurons.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Calpain; Cell Survival; Cells, Cultured; Cerebellum; Dipeptides; Enzyme Activation; Glutamic Acid; Hippocampus; Kainic Acid; Leucine; N-Methylaspartate; Neurons; Neuroprotective Agents; Nitric Oxide Synthase; Nitroarginine; Rats; Receptors, N-Methyl-D-Aspartate; Spectrin; Time Factors | 1995 |
Interaction of laminin with Entamoeba histolytica cysteine proteinases and its effect on amebic pathogenesis.
Topics: Amino Acid Sequence; Animals; Cysteine Endopeptidases; Entamoeba histolytica; Entamoebiasis; Laminin; Leucine; Molecular Sequence Data | 1995 |
Insulin resistance is mediated by a proteolytic fragment of the insulin receptor.
Topics: 3T3 Cells; Adipocytes; Animals; Female; Glycogen; Insulin; Insulin Resistance; Leucine; Mice; Obesity; Peptide Fragments; Phosphorylation; Rats; Rats, Zucker; Receptor, Insulin; Triglycerides | 1995 |
Aziridine analogs of [[trans-(epoxysuccinyl)-L-leucyl]amino]-4-guanidinobutane (E-64) as inhibitors of cysteine proteases.
Topics: Animals; Aziridines; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Hydrogen-Ion Concentration; Leucine; Papain; Rats; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 1995 |
Lovastatin enhances the photocytotoxicity of UVA radiation towards cultured N.C.T.C. 2544 human keratinocytes: prevention by cholesterol supplementation and by a cathepsin inhibitor.
Topics: Cathepsins; Cell Line; Cell Survival; Cholesterol; Humans; Keratinocytes; Leucine; Lovastatin; Ultraviolet Rays | 1995 |
An ultrastructural evaluation of the effects of cysteine-proteinase inhibitors on osteoclastic resorptive functions.
Topics: Animals; Animals, Newborn; Bone Resorption; Cathepsins; Cells, Cultured; Collagen; Cysteine Proteinase Inhibitors; Dentin; Diazomethane; Leucine; Mice; Microscopy, Electron, Scanning; Osteoclasts; Tooth Demineralization | 1995 |
Secretion and processing mechanisms of procathepsin L in bone resorption.
Topics: Animals; Blotting, Western; Bone and Bones; Bone Resorption; Calcitriol; Calcium; Cathepsin L; Cathepsins; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme Precursors; Humans; Leucine; Male; Parathyroid Hormone; Peptide Fragments; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; Teriparatide; Tumor Necrosis Factor-alpha | 1995 |
Structure, properties, mechanisms, and assays of cysteine protease inhibitors: cystatins and E-64 derivatives.
Topics: Animals; Cathepsins; Chromatography, Affinity; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytosol; Indicators and Reagents; Kinetics; Leucine; Liver; Lysosomes; Papain; Rats; Recombinant Proteins; Structure-Activity Relationship | 1995 |
Mechanisms of protein degradation in Trypanosoma cruzi.
Topics: Animals; Chloroquine; Cysteine Endopeptidases; Hydrogen-Ion Concentration; Intracellular Membranes; Leucine; Molecular Weight; Peptide Hydrolases; Protease Inhibitors; Protozoan Proteins; Puromycin; Time Factors; Trypanosoma cruzi; Ubiquitins | 1993 |
Excystment of Paragonimus westermani metacercariae by endogenous cysteine protease.
Topics: Animals; Chromatography, Ion Exchange; Collagen; Coumarins; Cysteine Endopeptidases; Dipeptides; Dithiothreitol; Electrophoresis, Polyacrylamide Gel; Fibronectins; Hydrogen-Ion Concentration; Iodoacetamide; Leucine; Leupeptins; Myosins; Oligopeptides; Pancreatic Elastase; Paragonimus; Temperature; Trypsin | 1995 |
Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors.
Topics: Amino Acid Sequence; Binding Sites; Cathepsin B; Crystallography, X-Ray; Dipeptides; Drug Design; Leucine; Molecular Sequence Data; Protein Conformation | 1995 |
Complete degradation of type X collagen requires the combined action of interstitial collagenase and osteoclast-derived cathepsin-B.
Topics: Animals; Cartilage, Articular; Cathepsin B; Cell Line; Cells, Cultured; Chick Embryo; Collagen; Collagenases; Cysteine Proteinase Inhibitors; Kinetics; Leucine; Matrix Metalloproteinase 1; Molecular Weight; Osteoclasts; Peptide Fragments; Protein Structure, Secondary; Recombinant Proteins; Substrate Specificity; Transfection | 1995 |
Calpain is implicated in rat myocardial injury after ischemia or reperfusion.
Topics: Animals; Calcium-Binding Proteins; Calpain; Creatine Kinase; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Leucine; Male; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Rats; Rats, Wistar | 1995 |
Role of calcium-activated neutral protease (calpain) in cell death in cultured neonatal rat cardiomyocytes during metabolic inhibition.
Topics: Animals; Animals, Newborn; Calcium; Calpain; Cell Death; Cells, Cultured; Chromatography, Affinity; Chromatography, Ion Exchange; Cysteine Proteinase Inhibitors; Enzyme Activation; Leucine; Leupeptins; Myocardium; Protease Inhibitors; Rats; Rats, Wistar | 1995 |
Modification of S1 subsite specificity in the cysteine protease cathepsin B.
Topics: Animals; Base Sequence; Binding Sites; Cathepsin B; Cystatin C; Cystatins; Cysteine Endopeptidases; Kinetics; Leucine; Liver; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Point Mutation; Protein Binding; Protein Engineering; Rats; Recombinant Proteins; Substrate Specificity | 1995 |
Trypanosoma cruzi: identification of proteinases in shed components of trypomastigote forms.
Topics: Animals; Antimalarials; Blotting, Western; Culture Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Leucine; Trypanosoma cruzi; Variant Surface Glycoproteins, Trypanosoma | 1994 |
Crystallin degradation and insolubilization in regions of young rat lens with calcium ionophore cataract.
Topics: Aging; Amino Acid Sequence; Animals; Calcimycin; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Lens, Crystalline; Leucine; Molecular Sequence Data; Organ Culture Techniques; Protein Denaturation; Rats; Rats, Sprague-Dawley; Solubility | 1995 |
The influence of the cysteine protease inhibitor L-trans-epoxysuccinyl-leucyl amido(4-guanidio)butane (E64) on photobiological effects of tetra(4-sulfonatophenyl)porphine.
Topics: Carcinoma in Situ; Cathepsins; Combined Modality Therapy; Cysteine Proteinase Inhibitors; Drug Synergism; Female; Humans; Leucine; Male; Photochemotherapy; Porphyrins; Radiation-Sensitizing Agents; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 1995 |
Plasmodium falciparum: effects of proteinase inhibitors on globin hydrolysis by cultured malaria parasites.
Topics: Animals; Antimalarials; Chymotrypsin; Coumarins; Cysteine Proteinase Inhibitors; Dipeptides; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Fluorescent Dyes; Globins; Humans; Hydrolysis; Leucine; Leupeptins; Oligopeptides; Pepstatins; Plasmodium falciparum; Vacuoles | 1995 |
Trichomonas vaginalis: amoeboid and flagellated forms synthesize similar proteinases.
Topics: Animals; Caseins; Culture Media; Cysteine Proteinase Inhibitors; Diazomethane; Endopeptidases; Leucine; Leupeptins; Lipoproteins; Trichomonas vaginalis | 1995 |
Entamoeba histolytica interactions with polarized human intestinal Caco-2 epithelial cells.
Topics: Animals; Biological Transport; Cell Adhesion; Cell Differentiation; Cell Line; Cell Membrane Permeability; Cell Polarity; Cytochalasin D; Electrophysiology; Entamoeba histolytica; Epithelial Cells; Epithelium; Humans; In Vitro Techniques; Intestinal Mucosa; Lactose; Leucine; Mannitol; Permeability | 1994 |
trans-epoxysuccinyl-L-leucylamido (4-guanidino)-butane (E-64) inhibits trypsin-catalysed hydrolysis possibly by binding in the S1-subsite.
Topics: Animals; Binding Sites; Catalysis; Cattle; Hydrolysis; Leucine; Trypsin; Trypsin Inhibitors | 1994 |
Lysosomes as photochemical targets.
Topics: Acetylglucosaminidase; Cathepsin B; Cathepsin L; Cathepsins; Cell Survival; Cells, Cultured; Cysteine Endopeptidases; Cytosol; Dihematoporphyrin Ether; Endopeptidases; Hydrogen-Ion Concentration; L-Lactate Dehydrogenase; Leucine; Light; Lysosomes; Porphyrins; Radiation-Sensitizing Agents | 1994 |
Proteinase activities during temperature-induced stage differentiation of species complexes of Leishmania.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Hot Temperature; Humans; Leishmania; Leucine; Mice; Mice, Inbred BALB C; Microscopy, Electron; Species Specificity; Substrate Specificity | 1994 |
The efficacy of aldose reductase inhibitor, antioxidant butylated hydroxytoluene and cysteine protease inhibitor E64 on hyperglycemia-induced metabolic changes in the organ-cultured bovine lens.
Topics: Aldehyde Reductase; Animals; Butylated Hydroxytoluene; Cataract; Cattle; Culture Techniques; Cysteine Proteinase Inhibitors; Hyperglycemia; Lens, Crystalline; Leucine; Magnetic Resonance Spectroscopy | 1994 |
Effects of exogenous protease effectors on beef tenderness development and myofibrillar degradation and solubility.
Topics: Animals; Calcimycin; Calcium; Calpain; Cathepsins; Cattle; Cysteine Proteinase Inhibitors; Diazomethane; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Glycoproteins; Leucine; Leupeptins; Male; Meat; Muscle Proteins; Muscles; Octoxynol; Pepstatins; Phenylmethylsulfonyl Fluoride; Postmortem Changes; Solubility | 1994 |
Leupeptin and E-64, inhibitors of cysteine proteinases, prevent gentamicin-induced lysosomal phospholipidosis in cultured rat fibroblasts.
Topics: Animals; Cells, Cultured; Cysteine Proteinase Inhibitors; Fibroblasts; Gentamicins; Leucine; Leupeptins; Lysosomes; Phospholipids; Rats | 1994 |
[Role of calpain on hypoxic myocyte injury].
Topics: Animals; Animals, Newborn; Calcium; Calcium-Binding Proteins; Calpain; Cell Death; Cell Hypoxia; Cysteine Proteinase Inhibitors; Heart; Hydrogen-Ion Concentration; Leucine; Myocardium; Rats; Rats, Wistar | 1994 |
E64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions.
Topics: Cathepsin B; Cysteine Proteinase Inhibitors; Kinetics; Leucine; Papain; Structure-Activity Relationship | 1994 |
Degradation of human IgA by Entamoeba histolytica.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Entamoeba histolytica; Humans; Immunoglobulin A; Ketones; Leucine; Subcellular Fractions | 1993 |
Effect of high hydrostatic pressure on the conversion of alpha-connectin to beta-connectin.
Topics: Animals; Antibodies, Monoclonal; Calcium; Calpain; Connectin; Egtazic Acid; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Hydrostatic Pressure; Leucine; Leupeptins; Molecular Weight; Muscle Proteins; Muscles; Protein Kinases; Rabbits | 1993 |
Role of calpain in hydrogen peroxide induced cataract.
Topics: Animals; Calcium; Calpain; Cataract; Crystallins; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Hydrogen Peroxide; Lens, Crystalline; Leucine; Organ Culture Techniques; Rats; Rats, Sprague-Dawley | 1993 |
Effects of membrane-associated cathepsin B on the activation of receptor-bound prourokinase and subsequent invasion of reconstituted basement membranes.
Topics: Basement Membrane; Biotin; Cathepsin B; Cell Line; Cell Membrane; Collagen; Cysteine Proteinase Inhibitors; Drug Combinations; Enzyme Activation; Humans; Laminin; Leucine; Proteoglycans; Recombinant Proteins; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1993 |
H2O2-mediated damage to lysosomal membranes of J-774 cells.
Topics: Acridine Orange; Adenosine Triphosphate; Animals; Cell Death; Chlorides; Cysteine Proteinase Inhibitors; Deferoxamine; Endocytosis; Ferric Compounds; Hydrogen Peroxide; Hydroxides; Hydroxyl Radical; Intracellular Membranes; Kinetics; Leucine; Lymphoma, Large B-Cell, Diffuse; Lysosomes; Mice; Microscopy, Electron; Trypan Blue; Tumor Cells, Cultured | 1993 |
pH dependent cytotoxicity of N-dodecylimidazole: a compound that acquires detergent properties under acidic conditions.
Topics: Animals; Antineoplastic Agents; Cell Count; Cysteine Proteinase Inhibitors; Detergents; Drug Interactions; Hydrogen-Ion Concentration; Imidazoles; Leucine; Mice; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1993 |
Epoxysuccinyl dipeptides as selective inhibitors of cathepsin B.
Topics: Cathepsin B; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Dipeptides; Kinetics; Leucine; Magnetic Resonance Spectroscopy; Papain; Proline | 1993 |
The two cysteine endopeptidases of legume seeds: purification and characterization by use of specific fluorometric assays.
Topics: Amino Acid Sequence; Cystatins; Cysteine Endopeptidases; Enzyme Stability; Fabaceae; Hydrogen-Ion Concentration; Iodoacetamide; Iodoacetates; Iodoacetic Acid; Leucine; Molecular Sequence Data; Molecular Weight; Peptides; Plant Proteins; Plants, Medicinal; Protease Inhibitors; Seeds; Substrate Specificity | 1993 |
Cysteine proteinase inhibitors block early steps in hemoglobin degradation by cultured malaria parasites.
Topics: Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Heme; Hemoglobins; Hydrogen-Ion Concentration; Hydrolysis; Leucine; Plasmodium falciparum; Protein Conformation; Protozoan Proteins; Vacuoles | 1996 |
Analysis of the production of soluble ICAM-1 molecules by human cells.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Northern; Blotting, Western; Cells, Cultured; Endopeptidases; Flow Cytometry; Gene Expression Regulation; Humans; Intercellular Adhesion Molecule-1; Interferon-gamma; Keratinocytes; Leucine; Molecular Sequence Data; Molecular Weight; Peptide Fragments; Polymerase Chain Reaction; Protease Inhibitors; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Messenger; Solubility | 1996 |
Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics simul
Topics: Amino Acid Sequence; Animals; Binding, Competitive; Catalysis; Cattle; Computer Simulation; Crystallography, X-Ray; Kinetics; Leucine; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Molecular Structure; Protein Conformation; Software; Structure-Activity Relationship; Trypsin; Trypsin Inhibitors | 1996 |
Proteinases in renal cell death.
Topics: Animals; Anti-Bacterial Agents; Antimycin A; Antipain; Carboxypeptidases; Cathepsin A; Cathepsin B; Cell Death; Coumarins; Cysteine; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Endopeptidases; Hydrocarbons, Fluorinated; Hydroquinones; Isocoumarins; Kidney Tubules, Proximal; L-Lactate Dehydrogenase; Leucine; Leupeptins; Lysosomes; Membrane Potentials; Pepstatins; Peroxides; Rabbits; Reactive Oxygen Species; Serine Proteinase Inhibitors; tert-Butylhydroperoxide; Tosyllysine Chloromethyl Ketone | 1996 |
Structure of rat procathepsin B: model for inhibition of cysteine protease activity by the proregion.
Topics: Animals; Binding Sites; Cathepsin B; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Leucine; Models, Molecular; Protein Conformation; Rats; Recombinant Proteins; Substrate Specificity | 1996 |
Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo.
Topics: Animals; Bone and Bones; Bone Resorption; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Endopeptidases; Female; Humans; Leucine; Mice; Ovariectomy; Rats; Rats, Sprague-Dawley | 1996 |
Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization.
Topics: Calcium; Calpain; Catalysis; Cysteine Proteinase Inhibitors; Erythrocytes; Globins; Humans; Leucine | 1996 |
Crystal structure of a caricain D158E mutant in complex with E-64.
Topics: Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Glutamic Acid; Leucine; Models, Molecular; Mutagenesis, Site-Directed; Plant Proteins; Protein Conformation; Recombinant Fusion Proteins | 1996 |
Promotion of heat-induced apoptosis in FM3A cells by protease inhibitors.
Topics: Animals; Apoptosis; Cell Cycle; Cysteine Proteinase Inhibitors; Female; Hot Temperature; Hyperthermia, Induced; Leucine; Mammary Neoplasms, Experimental; Mice; Pepstatins; Protease Inhibitors; Tumor Cells, Cultured | 1996 |
The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft.
Topics: Amino Acid Chloromethyl Ketones; Amino Acid Sequence; Cathepsin B; Computer Simulation; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Fruit; Hydrogen Bonding; Leucine; Leupeptins; Models, Molecular; Molecular Sequence Data; Mutation; Oligopeptides; Papain; Plant Proteins; Protein Processing, Post-Translational; Protein Structure, Secondary; Sequence Homology, Amino Acid | 1996 |
The binding mode of an E-64 analog to the active site of cathepsin B.
Topics: Binding Sites; Cathepsin B; Computer Simulation; Cysteine Proteinase Inhibitors; Dipeptides; Hydrogen Bonding; Leucine; Models, Molecular; Molecular Conformation; Monte Carlo Method; Structure-Activity Relationship | 1996 |
A cysteine protease that processes insect vitellin. Purification and partial characterization of the enzyme and the proenzyme.
Topics: Animals; Antimalarials; Chromatography, Gel; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Egg Proteins; Egg Yolk; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Precursors; Hydrogen-Ion Concentration; Leucine; Molecular Weight; Orthoptera | 1996 |
Mengo virus 3C proteinase: recombinant expression, intergenus substrate cleavage and localization in vivo.
Topics: 3C Viral Proteases; Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibodies, Viral; Capsid; Chlorides; Cysteine Endopeptidases; Enzyme Inhibitors; Ethylmaleimide; Female; HeLa Cells; Humans; Iodoacetamide; Leucine; Mengovirus; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptides; Protein Precursors; Recombinant Fusion Proteins; Substrate Specificity; Viral Proteins; Zinc Compounds | 1996 |
Protease activity associated with excystation of Cryptosporidium parvum oocysts.
Topics: alpha 1-Antitrypsin; Animals; Aprotinin; Caseins; Cryptosporidium parvum; Endopeptidases; Hydrolysis; Isoflurophate; Leucine; Phenylmethylsulfonyl Fluoride; Protease Inhibitors | 1996 |
Characterization of native falcipain, an enzyme involved in Plasmodium falciparum hemoglobin degradation.
Topics: Animals; Aspartic Acid Endopeptidases; Catalase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Hemoglobins; Humans; Kinetics; Leucine; Molecular Sequence Data; Molecular Weight; Plasmodium falciparum; Protein Denaturation; Reducing Agents; RNA, Protozoan; Vacuoles | 1996 |
Crystal structure of human osteoclast cathepsin K complex with E-64.
Topics: Binding Sites; Cathepsin K; Cathepsins; Cysteine Proteinase Inhibitors; Humans; Leucine; Models, Molecular; Molecular Conformation; Osteoclasts; Protein Structure, Secondary | 1997 |
Inhibition of carcinoma cell invasion and liver metastases formation by the cysteine proteinase inhibitor E-64.
Topics: Animals; Carcinoma, Lewis Lung; Cathepsin B; Cathepsin L; Cathepsins; Collagen; Cysteine Endopeptidases; Drug Combinations; Drug Screening Assays, Antitumor; Endopeptidases; Female; Laminin; Leucine; Liver Neoplasms, Experimental; Mice; Mice, Inbred C57BL; Neoplasm Invasiveness; Proteoglycans; Tumor Cells, Cultured | 1997 |
Blockade of calpain proteolytic activity rescues neurons from glutamate excitotoxicity.
Topics: Animals; Calpain; Cells, Cultured; Cysteine Proteinase Inhibitors; Dipeptides; Glutamic Acid; Glycoproteins; Hippocampus; Leucine; Neurons; Neuroprotective Agents; Neurotoxins; Rats | 1997 |
Cathepsin B fraction active at physiological pH of 7.5 is of prognostic significance in squamous cell carcinoma of human lung.
Topics: Adenocarcinoma; Adolescent; Adult; Aged; Aged, 80 and over; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Leucine; Lung; Lung Neoplasms; Middle Aged; Prognosis; Substrate Specificity; Survival Analysis | 1997 |
HLA-DR-restricted presentation of purified myelin basic protein is independent of intracellular processing.
Topics: Antigen Presentation; Antigens, Differentiation, B-Lymphocyte; Chromatography, High Pressure Liquid; Clone Cells; Cysteine Proteinase Inhibitors; Histocompatibility Antigens Class II; HLA-DR1 Antigen; Humans; Intracellular Fluid; Leucine; Lipid Metabolism; Myelin Basic Protein; Protein Binding; T-Lymphocytes | 1997 |
The crystal structure of human cathepsin L complexed with E-64.
Topics: Cathepsin L; Cathepsins; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Humans; Leucine; Models, Molecular; Recombinant Proteins | 1997 |
Biochemical characterization of the arginine-specific proteases of Porphyromonas gingivalis W50 suggests a common precursor.
Topics: Adhesins, Bacterial; Amino Acid Sequence; Arginine; Bacterial Proteins; Binding Sites; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Evolution, Molecular; Gingipain Cysteine Endopeptidases; Hemagglutinins; Hydrogen-Ion Concentration; Iodoacetamide; Iodoacetates; Iodoacetic Acid; Kinetics; Leucine; Molecular Sequence Data; Molecular Weight; Porphyromonas gingivalis; Protease Inhibitors; Substrate Specificity; Virulence | 1997 |
Mutations in reovirus outer-capsid protein sigma3 selected during persistent infections of L cells confer resistance to protease inhibitor E64.
Topics: Ammonium Chloride; Animals; Capsid; Capsid Proteins; Cysteine Proteinase Inhibitors; Drug Resistance, Microbial; Genes, Viral; Kinetics; L Cells; Leucine; Mammalian orthoreovirus 3; Mice; Mutation; Orthoreovirus; RNA-Binding Proteins; Virus Latency; Virus Replication | 1997 |
Identification of hemoglobin degradation products in Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Globins; Hemoglobins; Immunoblotting; Leucine; Molecular Sequence Data; Molecular Weight; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins | 1997 |
Cerulein-induced in vitro activation of trypsinogen in rat pancreatic acini is mediated by cathepsin B.
Topics: Amylases; Animals; Cathepsin B; Ceruletide; Cysteine Proteinase Inhibitors; Enzyme Activation; Gastrointestinal Agents; In Vitro Techniques; Leucine; Male; Pancreas; Rats; Rats, Wistar; Stimulation, Chemical; Time Factors; Trypsin; Trypsinogen | 1997 |
Immunocytochemical study of cathepsin L and rat salivary cystatin-3 in rat osteoclasts treated with E-64 in vivo.
Topics: Animals; Bone Matrix; Cathepsin L; Cathepsins; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Leucine; Lysosomes; Male; Microscopy, Immunoelectron; Osteoclasts; Rats; Rats, Wistar; Salivary Cystatins; Salivary Proteins and Peptides | 1997 |
Activation of calpain in lens: a review and proposed mechanism.
Topics: Amino Acid Sequence; Animals; Calcium; Calpain; Crystallins; Cysteine Proteinase Inhibitors; Glycoproteins; Lens, Crystalline; Leucine; Models, Biological; Rabbits; Sequence Analysis | 1997 |
Plasma leakage induced in postcapillary venules by the major cysteine-proteinase from Trypanosoma cruzi and its modulation by H1-blocker mepyramine.
Topics: Animals; Capillary Permeability; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Exudates and Transudates; Histamine H1 Antagonists; Host-Parasite Interactions; Leucine; Male; Mesocricetus; Protozoan Proteins; Pyrilamine; Trypanosoma cruzi; Venules | 1997 |
The expression and function of cystatin C and cathepsin B and cathepsin L during mouse embryo implantation and placentation.
Topics: Animals; Cathepsin B; Cathepsin L; Cathepsins; Cystatin C; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Decidua; Embryo Implantation; Endopeptidases; Female; Gene Expression; In Situ Hybridization; Leucine; Male; Mice; Placentation; Pregnancy; RNA, Messenger; Trophoblasts | 1997 |
Mechanisms of renal tubular cell hypertrophy: mitogen-induced suppression of proteolysis.
Topics: Animals; Calpain; Cell Cycle; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; Humans; Hypertrophy; Kidney Tubules, Proximal; Kinetics; Leucine; Leupeptins; Mitogens; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; Rabbits; Rats; Recombinant Proteins; Transforming Growth Factor beta | 1997 |
Involvement of p21racA, phosphoinositide 3-kinase, and vacuolar ATPase in phagocytosis of bacteria and erythrocytes by Entamoeba histolytica: suggestive evidence for coincidental evolution of amebic invasiveness.
Topics: Ammonium Chloride; Androstadienes; Animals; Anti-Bacterial Agents; Bacteria; Biological Evolution; Cysteine Proteinase Inhibitors; Entamoeba histolytica; Erythrocytes; GTP-Binding Proteins; Hydrogen-Ion Concentration; Immunologic Capping; Leucine; Macrolides; Macrophages; Models, Biological; Monensin; Mutation; Phagocytosis; Phosphatidylinositol 3-Kinases; Pinocytosis; rac GTP-Binding Proteins; Transformation, Genetic; Vacuoles; Wortmannin | 1997 |
EGF receptor ligands are a large fraction of in vitro branching morphogens secreted by embryonic kidney.
Topics: Animals; Aprotinin; Cell Line; Coculture Techniques; Collagen; Cysteine Proteinase Inhibitors; Embryonic Induction; Enzyme Inhibitors; Epithelium; ErbB Receptors; Hepatocyte Growth Factor; Kidney; Kidney Medulla; Kidney Tubules, Collecting; Leucine; Ligands; Mice; Mice, Knockout; Morphogenesis; Nitriles; Phenanthrolines; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins c-met; Proto-Oncogenes; Quinazolines; Receptor Protein-Tyrosine Kinases; Transforming Growth Factor alpha; Tyrphostins | 1997 |
E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group.
Topics: Cathepsin B; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Magnetic Resonance Spectroscopy; Molecular Structure; Salts; Spectrometry, Mass, Fast Atom Bombardment; Stereoisomerism | 1997 |
Experimental evidence for the essential role of the C-terminal residue in the strict aminopeptidase activity of the thiol aminopeptidase PepC, a bacterial bleomycin hydrolase.
Topics: Alanine; Aminopeptidases; Consensus Sequence; Cysteine Endopeptidases; Hot Temperature; Hydrogen-Ion Concentration; Lactococcus lactis; Leucine; Mutagenesis, Site-Directed; Protease Inhibitors; Protein Denaturation; Recombinant Proteins; Sequence Deletion; Substrate Specificity | 1997 |
Effects of ethylene glycol tetraacetic acid, A23187 and calmodulin, calcium activated neutral proteinase antagonists on melatonin secretion in perifused chick pineal gland.
Topics: Animals; Antidiarrheals; Benzimidazoles; Calcimycin; Calcium; Calmodulin; Chelating Agents; Chickens; Cysteine Proteinase Inhibitors; Darkness; Dopamine Antagonists; Egtazic Acid; Glycoproteins; Homeostasis; Ionophores; Leucine; Male; Melatonin; Organ Culture Techniques; Perfusion; Pineal Gland; Trifluoperazine | 1998 |
Two-dimensional zymography for analysis of proteolytic enzymes in human pure pancreatic juice.
Topics: Aged; Cysteine Proteinase Inhibitors; Electrophoresis, Gel, Two-Dimensional; Endopeptidases; Female; Humans; Isoelectric Focusing; Leucine; Male; Middle Aged; Pancreatic Juice | 1998 |
DNA methylation by wheat cytosine DNA methyltransferase: modulation by protease inhibitor E-64.
Topics: Cysteine Proteinase Inhibitors; Dithiothreitol; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA, Bacterial; DNA, Plant; Enzyme Activation; Leucine; Molecular Weight; Plants; Substrate Specificity; Sulfhydryl Compounds; Triticum | 1998 |
Isolation and characterization of a 40 kDa cysteine protease from Gymnophalloides seoi adult worms.
Topics: Animals; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hemoglobins; Host-Parasite Interactions; Humans; Immunoglobulins; Leucine; Molecular Weight; Trematoda | 1998 |
Soluble factor(s) released from neutrophils activates endothelial cell matrix metalloproteinase-2.
Topics: Aprotinin; Cells, Cultured; Culture Media, Conditioned; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Enzyme Activation; Gelatinases; Humans; Leucine; Matrix Metalloproteinase 2; Metalloendopeptidases; Neutrophil Activation; Neutrophils; Pepstatins; Phenanthrolines; Phenylalanine; Protease Inhibitors; Proteins; Serine Proteinase Inhibitors; Serpins; Solubility; Thiophenes; Time Factors; Umbilical Veins | 1998 |
Activation of tumor cell matrix metalloproteinase-2 by neutrophil proteinases requires expression of membrane-type 1 matrix metalloproteinase.
Topics: alpha 1-Antitrypsin; Aprotinin; Collagenases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Activation; Enzyme Precursors; Fibrosarcoma; Gelatinases; Humans; Leucine; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Metalloendopeptidases; Neoplasm Invasiveness; Neutrophils; Pepstatins; Phenylalanine; Protease Inhibitors; Serine Proteinase Inhibitors; Thiophenes; Transfection; Tumor Cells, Cultured | 1998 |
Cysteine proteinases and matrix metalloproteinases play distinct roles in the subosteoclastic resorption zone.
Topics: Amides; Amino Acids, Branched-Chain; Animals; Bone Matrix; Bone Resorption; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Hydrogen-Ion Concentration; Leucine; Metalloendopeptidases; Mice; Morpholines; Osteoclasts; Protease Inhibitors; Skull; Time Factors | 1998 |
Proteolysis of connexin43-containing gap junctions in normal and heat-stressed cardiac myocytes.
Topics: Acetylcysteine; Ammonium Chloride; Animals; Cells, Cultured; Chloroquine; Connexin 43; Cysteine Proteinase Inhibitors; Fluorescent Antibody Technique; Gap Junctions; Hot Temperature; HSP70 Heat-Shock Proteins; Immunoblotting; Leucine; Leupeptins; Lysosomes; Microscopy, Electron; Myocardium; Oligopeptides; Precipitin Tests; Protease Inhibitors; Rats | 1998 |
Bax cleavage is mediated by calpain during drug-induced apoptosis.
Topics: Alanine; Amino Acid Sequence; Apoptosis; Aspartic Acid; bcl-2-Associated X Protein; Binding Sites; Calpain; Camptothecin; Cell Death; Cell Extracts; Cell Membrane; Cysteine Proteinase Inhibitors; Dipeptides; HL-60 Cells; Humans; Hydrolysis; Leucine; Molecular Sequence Data; Mutation; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Substrate Specificity | 1998 |
Occurrence of digestive cysteine proteases in Perillus bioculatus, a natural predator of the Colorado potato beetle.
Topics: Animals; Coleoptera; Cystatin A; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hemiptera; Hydrogen-Ion Concentration; Leucine; Pest Control, Biological; Recombinant Fusion Proteins; Tosyl Compounds | 1998 |
Dexamethasone stimulates proteasome- and calcium-dependent proteolysis in cultured L6 myotubes.
Topics: Adenosine Triphosphate; Animals; Calcium; Calpain; Cathepsin B; Cathepsin D; Cells, Cultured; Chloroquine; Cysteine Endopeptidases; Deoxyglucose; Dexamethasone; Leucine; Leupeptins; Methylamines; Mifepristone; Multienzyme Complexes; Muscle, Skeletal; Proteasome Endopeptidase Complex; Proteins; Rats; Tyrosine; Ubiquitins | 1998 |
Central role of hemoglobin degradation in mechanisms of action of 4-aminoquinolines, quinoline methanols, and phenanthrene methanols.
Topics: Amodiaquine; Antimalarials; Chloroquine; Hemoglobins; Humans; Leucine; Mefloquine; Phenanthrenes; Primaquine; Protease Inhibitors | 1998 |
Enzymatically active papain preferentially induces an allergic response in mice.
Topics: Animals; Cell Degranulation; Cysteine Proteinase Inhibitors; Hypersensitivity; Immunoglobulin G; Leucine; Male; Mast Cells; Mice; Mice, Inbred BALB C; Papain; Vaccination | 1998 |
Purification of active cysteine proteases by affinity chromatography with attached E-64 inhibitor.
Topics: Aspergillus; Chromatography, Affinity; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Kinetics; Leucine; Sepharose | 1999 |
A novel egg-derived tyrosine phosphatase, EDTP, that participates in the embryogenesis of Sarcophaga peregrina (flesh fly).
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cathepsin L; Cathepsins; Cloning, Molecular; Consensus Sequence; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Diptera; Egg Proteins; Embryo, Nonmammalian; Embryonic Development; Endopeptidases; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Insect Proteins; Leucine; Molecular Sequence Data; Oocytes; Protein Tyrosine Phosphatases; RNA, Messenger | 1999 |
Matrix metalloproteinases and lysosomal cysteine proteases in osteoclasts contribute to bone resorption through distinct modes of action.
Topics: Animals; Base Sequence; Bone Resorption; Cysteine Endopeptidases; DNA Primers; Leucine; Lysosomes; Metalloendopeptidases; Osteoblasts; Phenylalanine; Protease Inhibitors; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; Thiophenes | 1999 |
Characterization of matrix metalloproteinases in human urine: alterations during adolescence.
Topics: Adolescent; Adult; Age Factors; Caseins; Child; Collagenases; Cysteine Proteinase Inhibitors; Edetic Acid; Enzyme Activation; Female; Gelatin; Gelatinases; Humans; Immunoblotting; Leucine; Male; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Middle Aged; Molecular Weight; Precipitin Tests; Tissue Inhibitor of Metalloproteinase-1 | 1999 |
Structural basis of inhibition of cysteine proteases by E-64 and its derivatives.
Topics: Binding Sites; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Epoxy Compounds; Leucine; Models, Molecular; Protein Conformation; Static Electricity; Structure-Activity Relationship; Succinic Acid | 1999 |
Functional heterogeneity of osteoclasts: matrix metalloproteinases participate in osteoclastic resorption of calvarial bone but not in resorption of long bone.
Topics: Amides; Animals; Bone Resorption; Cathepsins; Cattle; Collagen; Extracellular Matrix; Immunohistochemistry; In Vitro Techniques; Leucine; Metalloendopeptidases; Mice; Morpholines; Osteoclasts; Protease Inhibitors; Rabbits | 1999 |
Inflammatory mediators regulate cathepsin S in macrophages and microglia: A role in attenuating heparan sulfate interactions.
Topics: Animals; Blotting, Northern; Blotting, Western; Cathepsin B; Cathepsin L; Cathepsins; Cell Adhesion; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Fibroblast Growth Factor 2; Granulocyte-Macrophage Colony-Stimulating Factor; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Inflammation; Interferon-alpha; Interferon-gamma; Interleukin-1; Leucine; Lipopolysaccharides; Macrophages; Mice; Microglia; Proteoglycans; RNA, Messenger; Tumor Necrosis Factor-alpha | 1999 |
C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycopeptides; Humans; Leucine; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Pepstatins; Presenilin-1; Presenilin-2; Proteasome Endopeptidase Complex; Recombinant Proteins; Sulfones; Transfection | 1999 |
Oxidation enhances calpain-induced turbidity in young rat lenses.
Topics: Animals; Antioxidants; Calpain; Cataract; Crystallins; Culture Techniques; Cysteine Proteinase Inhibitors; Diamide; Dithioerythritol; Drug Synergism; Glutathione; Lens, Crystalline; Leucine; Oxidants; Oxidation-Reduction; Peptide Hydrolases; Rats; Rats, Sprague-Dawley | 1999 |
Immunological control of scab mites: digestive enzymes as candidate compounds.
Topics: Aminopeptidases; Animals; Colorimetry; Cysteine Proteinase Inhibitors; Edetic Acid; Esterases; Glycoside Hydrolases; Hemoglobins; Leucine; Mite Infestations; Mites; Pepstatins; Phenylmethylsulfonyl Fluoride; Phosphoric Monoester Hydrolases; Protease Inhibitors; Rabbits; Sheep; Tick Control | 1999 |
Cathepsin B inhibitors do not prevent the intracellular trypsinogen activation by secretagogue hyperstimulation.
Topics: Acute Disease; Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Humans; Leucine; Pancreatitis; Piperazines; Protease Inhibitors; Trypsinogen | 1999 |
Cloning and expression of rhesus monkey cathepsin K.
Topics: Amino Acid Sequence; Animals; Cathepsin K; Cathepsins; CHO Cells; Cloning, Molecular; Coumarins; Cricetinae; Cystatins; DNA Primers; DNA, Complementary; Enzyme Inhibitors; Enzyme Precursors; Female; Gene Expression; Humans; Leucine; Macaca mulatta; Molecular Sequence Data; Oligopeptides; Peptide Fragments; Polynucleotide Adenylyltransferase; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Substrate Specificity | 1999 |
Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells.
Topics: Adenoviridae; Animals; Apoptosis; Carcinoma, Embryonal; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Leucine; Leupeptins; Mice; Mitosis; Multienzyme Complexes; Neurons; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Retinoblastoma-Binding Protein 1; RNA, Messenger; S Phase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured; Ubiquitins | 1999 |
Transgenic Arabidopsis leaf tissue expressing a modified oryzacystatin shows resistance to the field slug Deroceras reticulatum (Müller).
Topics: Animals; Arabidopsis; Cystatins; Cysteine Proteinase Inhibitors; Leucine; Leupeptins; Mollusca; Plant Leaves; Plants, Genetically Modified; Recombinant Proteins | 1999 |
Location of the binding site for chloride ion activation of cathepsin C.
Topics: Binding Sites; Cathepsin C; Chlorides; Cysteine Proteinase Inhibitors; Dipeptidyl-Peptidases and Tripeptidyl-Peptidases; Enzyme Activation; Guanidine; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Iodoacetates; Kinetics; Leucine; Models, Biological; Substrate Specificity | 1999 |
Effect of the selective and non-selective cysteine protease inhibitors on the intracellular processing of interleukin 6 by HEPG2 cells.
Topics: Cathepsin B; Cathepsins; Cell Membrane Permeability; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Interleukin-6; Intracellular Fluid; Iodine Radioisotopes; Isotope Labeling; Ketones; Leucine; Leupeptins; Recombinant Proteins; Time Factors; Tumor Cells, Cultured | 1999 |
Programmed cell death of the dinoflagellate Peridinium gatunense is mediated by CO(2) limitation and oxidative stress.
Topics: Animals; Apoptosis; Carbon Dioxide; Catalase; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dinoflagellida; Fresh Water; Hydrogen Peroxide; Hydrogen-Ion Concentration; Leucine; Oxidative Stress; Protozoan Proteins; Reactive Oxygen Species; Seasons | 1999 |
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
Topics: Acetylcysteine; Administration, Topical; Calcitriol; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Gene Expression Regulation; Humans; Keratinocytes; Leucine; Leupeptins; Multienzyme Complexes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Receptors, Calcitriol; Skin; Steroid Hydroxylases; Ubiquitins; Vitamin D3 24-Hydroxylase | 1999 |
Autocrine production of matrix metalloproteinase-2 is required for human airway smooth muscle proliferation.
Topics: Aprotinin; Asthma; Autocrine Communication; Blood Proteins; Cell Division; Cells, Cultured; Chelating Agents; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Edetic Acid; Extracellular Matrix; Hemostatics; Humans; Hydroxamic Acids; Leucine; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Mitogens; Muscle, Smooth; Platelet-Derived Growth Factor; Protease Inhibitors; Serine Proteinase Inhibitors; Thrombin; Thymidine; Trachea | 1999 |
Reduced MAP kinase phosphatase-1 degradation after p42/p44MAPK-dependent phosphorylation.
Topics: Animals; Blood; Cell Cycle Proteins; Cell Division; Cell Line; Cricetinae; Culture Media; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dual Specificity Phosphatase 1; Estradiol; Humans; Immediate-Early Proteins; Leucine; Leupeptins; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Multienzyme Complexes; Mutation; Nitrophenols; Organophosphorus Compounds; Phosphoprotein Phosphatases; Phosphorylation; Proteasome Endopeptidase Complex; Protein Phosphatase 1; Protein Tyrosine Phosphatases; Ubiquitins | 1999 |
Cathepsins B and L in synovial fluids from patients with rheumatoid arthritis and the effect of cathepsin B on the activation of pro-urokinase.
Topics: Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Cathepsin B; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Endopeptidases; Enzyme Activation; Enzyme Precursors; Female; Humans; Leucine; Liver; Male; Middle Aged; Osteoarthritis; Recombinant Proteins; Synovial Fluid; Urokinase-Type Plasminogen Activator | 2000 |
Effect of protease inhibitors on angiotensin-converting enzyme activity in human T-lymphocytes.
Topics: Adult; Aminopeptidases; Angiotensin-Converting Enzyme Inhibitors; Calpain; Captopril; Cathepsins; Chymotrypsin; Cysteine Proteinase Inhibitors; Humans; Leucine; Leupeptins; Lisinopril; Lymphocyte Activation; Male; Oligopeptides; Peptidyl-Dipeptidase A; Protease Inhibitors; T-Lymphocytes | 2000 |
Der p 1 and Der f 1, the highly related and major allergens from house dust mites, are differentially affected by a plant cystatin.
Topics: Allergens; Animals; Antigens, Dermatophagoides; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Glycoproteins; Kinetics; Leucine; Mites; Plant Proteins; Trypsin Inhibitor, Bowman-Birk Soybean | 2000 |
Evidence of proteolytic activation of transforming growth factor beta in synovial fluid.
Topics: Aprotinin; Arthritis; Enzyme Activation; Humans; Leucine; Matrix Metalloproteinase 3; Matrix Metalloproteinase Inhibitors; Phenanthrolines; Protease Inhibitors; Protein Isoforms; Synovial Fluid; Transforming Growth Factor beta; Transforming Growth Factor beta2 | 2000 |
Release of gelonin from endosomes and lysosomes to cytosol by photochemical internalization.
Topics: Cysteine Proteinase Inhibitors; Cytosol; Endosomes; Fluorescence; Indoles; Intracellular Membranes; Leucine; Lysosomes; Microscopy, Phase-Contrast; Organometallic Compounds; Photochemistry; Plant Proteins; Porphyrins; Radiation-Sensitizing Agents; Ribosome Inactivating Proteins, Type 1; Temperature; Tumor Cells, Cultured | 2000 |
Inhibition of cysteine and aspartyl proteinases in the alfalfa weevil midgut with biochemical and plant-derived proteinase inhibitors.
Topics: Animals; Aspartic Acid Endopeptidases; Coleoptera; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Digestive System; Leucine; Medicago sativa; Pepstatins | 2000 |
Epoxide electrophiles as activity-dependent cysteine protease profiling and discovery tools.
Topics: Affinity Labels; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dendritic Cells; Disease Progression; Epoxy Compounds; Gene Expression Regulation, Enzymologic; Kidney; Leucine; Mice; Molecular Probes; Neoplasm Proteins; Organ Specificity; Peptide Library; Peptides; Rats; Skin Neoplasms; Substrate Specificity; Tumor Cells, Cultured | 2000 |
Ultrastructural changes associated with accumulation of inclusion bodies in rat retinal pigment epithelium.
Topics: Animals; Cathepsins; Cysteine Proteinase Inhibitors; Granuloma, Foreign-Body; Inclusion Bodies; Injections; Leucine; Photoreceptor Cells, Vertebrate; Pigment Epithelium of Eye; Rats; Rats, Sprague-Dawley | 2000 |
Inhibition of apoptosis in cultured porcine granulosa cells by inhibitors of caspase and serine protease activity.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Caspase Inhibitors; Caspases; Cell Membrane; Cysteine Proteinase Inhibitors; DNA Fragmentation; Electrophoresis, Agar Gel; Estradiol; Female; Flow Cytometry; Granulosa Cells; Leucine; Leupeptins; Microscopy, Fluorescence; Phenylmethylsulfonyl Fluoride; Progesterone; Radioimmunoassay; Regression Analysis; Serine Proteinase Inhibitors; Swine; Tosylphenylalanyl Chloromethyl Ketone | 2000 |
Determinants for the drug release from T-0128, camptothecin analogue-carboxymethyl dextran conjugate.
Topics: Animals; Antineoplastic Agents, Phytogenic; Cattle; Cysteine Endopeptidases; Dextrans; Dipeptides; Humans; Leucine; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Prodrugs; Rats; Solubility; Species Specificity; Topotecan | 2000 |
Malaria parasite exit from the host erythrocyte: a two-step process requiring extraerythrocytic proteolysis.
Topics: Animals; Cell Survival; Endopeptidases; Erythrocyte Membrane; Erythrocytes; Fluorescent Antibody Technique, Indirect; Histocytochemistry; Humans; Leucine; Membrane Proteins; Microscopy, Electron; Plasmodium falciparum; Protease Inhibitors | 2001 |
Adaptation of reovirus to growth in the presence of protease inhibitor E64 segregates with a mutation in the carboxy terminus of viral outer-capsid protein sigma3.
Topics: Adaptation, Physiological; Animals; Capsid; Capsid Proteins; Cathepsin D; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; L Cells; Leucine; Mice; Mutation; Reoviridae; RNA-Binding Proteins; Structure-Activity Relationship; Virus Assembly | 2001 |
Inhibition of endosomal insulin-like growth factor-I processing by cysteine proteinase inhibitors blocks receptor-mediated functions.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Blotting, Western; Cell Membrane; Chromatography, High Pressure Liquid; Cysteine Proteinase Inhibitors; Dipeptides; DNA; Dose-Response Relationship, Drug; Endosomes; Female; Flow Cytometry; Humans; Insulin-Like Growth Factor I; Kinetics; Leucine; Ligands; Liver; Male; Mice; Models, Biological; Neoplasm Metastasis; Phosphorylation; Precipitin Tests; Protein Binding; Proteins; Rats; Rats, Sprague-Dawley; Receptor, IGF Type 1; Shc Signaling Adaptor Proteins; Signal Transduction; Src Homology 2 Domain-Containing, Transforming Protein 1; Time Factors; Tumor Cells, Cultured; Tyrosine | 2001 |
Quantification of the expression levels of lysosomal cysteine proteinases in purified human osteoclastic cells by competitive RT-PCR.
Topics: Acid Phosphatase; Adult; Bone Marrow Cells; Bone Resorption; Calcitonin; Cathepsin K; Cathepsins; Cysteine Endopeptidases; DNA Primers; Dose-Response Relationship, Drug; Female; Fluorescent Antibody Technique, Indirect; Gene Expression; Giant Cell Tumor of Bone; Glyceraldehyde-3-Phosphate Dehydrogenases; Humans; Isoenzymes; Leucine; Osteoblasts; Osteoclasts; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tartrate-Resistant Acid Phosphatase; Tumor Cells, Cultured | 2001 |
Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Aprotinin; Autoantigens; Carrier Proteins; Caspases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Herpesvirus 4, Human; Humans; Hydrolysis; Leucine; Leupeptins; Microfilament Proteins; Molecular Weight; Organ Specificity; Pepstatins; Sjogren's Syndrome; Trans-Activators; Tumor Cells, Cultured; Viral Proteins; Virus Activation | 2001 |
Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.
Topics: Animals; Baculoviridae; Cell Line; Cysteine Proteinase Inhibitors; Genetic Vectors; Insecta; Leucine; Leupeptins; Recombinant Proteins; Transfection | 2001 |
Mechanism of attenuation of skeletal muscle protein catabolism in cancer cachexia by eicosapentaenoic acid.
Topics: Adenocarcinoma; Adenosine Triphosphate; Animals; Cachexia; Calcium; Colonic Neoplasms; Cysteine Proteinase Inhibitors; Eicosapentaenoic Acid; Female; Leucine; Lysosomes; Mice; Muscle Proteins; Muscle, Skeletal; Peptide Hydrolases | 2001 |
Space shuttle flight (STS-90) enhances degradation of rat myosin heavy chain in association with activation of ubiquitin-proteasome pathway.
Topics: Animals; Calpain; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Enzyme Precursors; Hindlimb Suspension; Leucine; Ligases; Models, Biological; Multienzyme Complexes; Muscle, Skeletal; Muscular Atrophy; Myosin Heavy Chains; Proteasome Endopeptidase Complex; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Space Flight; Ubiquitins; Weightlessness; Weightlessness Simulation | 2001 |
3-hydroxy-3-methylglutaryl coenzyme A reductase is sterol-dependently cleaved by cathepsin L-type cysteine protease in the isolated endoplasmic reticulum.
Topics: Acetylcysteine; Animals; Cathepsin L; Cathepsins; Cell Extracts; Cell Line; Cell Membrane Permeability; Cricetinae; Cysteine Endopeptidases; Endopeptidases; Endoplasmic Reticulum; Epoxy Compounds; Hydrogen-Ion Concentration; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent; Intracellular Membranes; Leucine; Lysosomes; Multienzyme Complexes; Protease Inhibitors; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Pyridines; Sonication; Sterols | 2001 |
Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration.
Topics: alpha-Amylases; Amino Acid Sequence; Animals; Cell Movement; Cell Size; Extracellular Matrix; Genes, Dominant; Humans; Hyaluronan Receptors; Leucine; Ligands; Matrix Metalloproteinase 14; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Mice; Molecular Sequence Data; Neoplasm Invasiveness; Pancreatic Neoplasms; Phenylalanine; Plant Proteins; Protein Processing, Post-Translational; Sequence Deletion; Solubility; Sulfones; Thiophenes; Tissue Inhibitor of Metalloproteinase-1; Tissue Inhibitor of Metalloproteinase-2; Trypsin Inhibitors; Tumor Cells, Cultured | 2001 |
Defining a link between gap junction communication, proteolysis, and cataract formation.
Topics: Animals; Calcium; Calpain; Cataract; Cell Communication; Connexins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gap Junctions; Lens, Crystalline; Leucine; Mice; Mice, Inbred Strains; Mice, Knockout; Organ Culture Techniques | 2001 |
The role of calpain in caspase activation during etoposide induced apoptosis in T cells.
Topics: Animals; Apoptosis; Calpain; Caspases; Cysteine Proteinase Inhibitors; Dipeptides; Enzyme Activation; Etoposide; Fas Ligand Protein; Hybridomas; Leucine; Membrane Glycoproteins; Mice; T-Lymphocytes | 2001 |
Elevated levels of cathepsin B in human glioblastoma cell lines.
Topics: beta-Galactosidase; Blotting, Northern; Blotting, Western; Brain Neoplasms; Cathepsin B; Chloramphenicol O-Acetyltransferase; Clone Cells; Collagen; Cysteine Proteinase Inhibitors; Drug Combinations; Glioblastoma; Humans; Laminin; Leucine; Promoter Regions, Genetic; Proteoglycans; Tumor Cells, Cultured | 2001 |
Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design.
Topics: Cathepsin B; Cathepsin K; Cathepsins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Drug Design; Enzyme Inhibitors; Exopeptidases; Fluorescent Dyes; Humans; Leucine; Models, Chemical; Substrate Specificity | 2001 |
Therapeutic effects of cysteine protease inhibition in allergic lung inflammation: inhibition of allergen-specific T lymphocyte migration.
Topics: Allergens; Animals; Cathepsin B; Cell Division; Cell Line; Cell Membrane; Cell Movement; Cysteine Proteinase Inhibitors; Extracellular Space; Female; Hematopoietic Stem Cells; Leucine; Lung; Lymphocyte Activation; Mice; Mice, Inbred BALB C; Ovalbumin; Pneumonia; T-Lymphocytes | 2001 |
Biochemical alteration of membrane-associated IL-6 RI (80-kDa) in adherent macrophages and vascular endothelium.
Topics: Animals; Aspartic Acid Endopeptidases; Buffers; Calcimycin; Cathepsin D; Cattle; Cell Adhesion; Cell Membrane; Citrates; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Female; Leucine; Macrophages; N-Formylmethionine Leucyl-Phenylalanine; Pepstatins; Receptors, Interleukin-6; Sodium Citrate | 2001 |
Role of CsrR, hyaluronic acid, and SpeB in the internalization of Streptococcus pyogenes M type 3 strain by epithelial cells.
Topics: Amino Acid Sequence; Bacterial Capsules; Bacterial Proteins; Base Sequence; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Bacterial; Endocytosis; Epithelial Cells; Gene Expression Regulation, Bacterial; Glucuronosyltransferase; Glycosyltransferases; Humans; Hyaluronan Synthases; Hyaluronic Acid; Leucine; Membrane Proteins; Molecular Sequence Data; Mutagenesis; Repressor Proteins; Sequence Analysis, DNA; Streptococcus pyogenes; Transcription, Genetic; Transferases; Tumor Cells, Cultured; Xenopus Proteins | 2002 |
Lysosomal proteases as potential targets for the induction of apoptotic cell death in human neuroblastomas.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Brain Neoplasms; Caspase Inhibitors; Caspases; Cathepsin B; Cathepsin D; Cell Survival; Chromatin; Cysteine Proteinase Inhibitors; Dipeptides; Humans; Leucine; Lysosomes; Neuroblastoma; Pepstatins; Tumor Cells, Cultured | 2002 |
A selective inhibitor of matrix metalloproteinases inhibits the migration of isolated osteoclasts by increasing the life span of podosomes.
Topics: Actins; Animals; Bone Resorption; Cell Movement; Cells, Cultured; Cysteine Proteinase Inhibitors; Glycine; Hydroxamic Acids; Leucine; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Molecular Structure; Osteoclasts; Protease Inhibitors; Rabbits | 2002 |
Differential activity of cathepsin L in human placenta at two different stages of gestation.
Topics: Adult; Blotting, Southern; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Female; Humans; Immunohistochemistry; Leucine; Peptides; Placenta; Pregnancy; Pregnancy Trimester, First; Pregnancy Trimester, Third; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2002 |
A tomato cysteine protease required for Cf-2-dependent disease resistance and suppression of autonecrosis.
Topics: Alleles; Amino Acid Sequence; Base Sequence; Cladosporium; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression Regulation, Plant; Genes, Plant; Immunity, Innate; Leucine; Molecular Sequence Data; Mutation; Nicotiana; Phenotype; Plant Diseases; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Promoter Regions, Genetic; Recombinant Fusion Proteins; Solanum lycopersicum; Transgenes | 2002 |
E 64.
Topics: Animals; Antineoplastic Agents; Humans; Leucine | 2002 |
Stage-specific antimalarial activity of cysteine protease inhibitors.
Topics: Animals; Antimalarials; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Erythrocytes; Gene Expression Regulation, Developmental; Hemoglobins; Hydrolysis; Leucine; Leupeptins; Plasmodium falciparum; Time Factors | 2002 |
A noninvasive cell-based assay for monitoring proteolytic activity within a specific subcellular compartment.
Topics: Amino Acid Sequence; Biological Assay; Cathepsin L; Cathepsins; Cysteine Endopeptidases; Green Fluorescent Proteins; HeLa Cells; Humans; Hydrogen-Ion Concentration; Leucine; Luminescent Proteins; Lysosomes; Molecular Sequence Data; Recombinant Fusion Proteins; Spectrometry, Fluorescence | 2002 |
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.
Topics: Aged; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Elasticity; Female; Humans; Leucine; Macrophages, Alveolar; Male; Matrix Metalloproteinase 12; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Metalloendopeptidases; Middle Aged; Pulmonary Disease, Chronic Obstructive; Serine Endopeptidases; Serine Proteinase Inhibitors; Smoking | 2002 |
Molecular and biochemical characterisation of two aspartic proteinases TcAP1 and TcAP2 from Theobroma cacao seeds.
Topics: Amino Acid Sequence; Aspartic Acid Endopeptidases; Cacao; Cloning, Molecular; Coumarins; DNA, Complementary; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Plant; Hydrogen-Ion Concentration; Isocoumarins; Isoenzymes; Leucine; Molecular Sequence Data; Pepstatins; Phylogeny; Plant Proteins; RNA, Messenger; Seeds; Sequence Analysis, DNA; Sequence Homology, Amino Acid; Yarrowia | 2002 |
pH Dependence of inhibitors targeting the occluding loop of cathepsin B.
Topics: Amino Acid Sequence; Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Drug Design; Humans; Hydrogen-Ion Concentration; Kinetics; Leucine; Liver; Phenylalanine; Piperazines; Protein Binding; Protein Structure, Secondary; Substrate Specificity; Sulfones; Tosyl Compounds | 2002 |
Cysteine protease activity is required for surfactant protein B processing and lamellar body genesis.
Topics: Base Sequence; Blotting, Western; Cathepsin H; Cathepsins; Cell Differentiation; Cysteine Endopeptidases; DNA Primers; Fluorescent Antibody Technique; Humans; Leucine; Lung; Microscopy, Electron; Protein Processing, Post-Translational; Pulmonary Surfactant-Associated Protein B; Pulmonary Surfactant-Associated Protein C; Reverse Transcriptase Polymerase Chain Reaction | 2003 |
Specific biological functions of vacuolar-type H(+)-ATPase and lysosomal cysteine proteinase, cathepsin K, in osteoclasts.
Topics: Animals; Animals, Newborn; Bone Marrow Cells; Cathepsin K; Cathepsins; Cells, Cultured; Coculture Techniques; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; Leucine; Lysosomes; Macrolides; Mice; Mice, Inbred Strains; Osteoclasts; Vacuolar Proton-Translocating ATPases | 2003 |
Selective modulation of superantigen-induced responses by streptococcal cysteine protease.
Topics: Bacterial Proteins; Cell Division; Culture Media, Conditioned; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leucine; Lymphocytes; Streptococcus; Superantigens | 2003 |
Thiol-activated serine proteinases from nymphal hemolymph of the African migratory locust, Locusta migratoria migratorioides.
Topics: Africa; Animal Migration; Animals; Cysteine Proteinase Inhibitors; Enzyme Activation; Grasshoppers; Hemolymph; Hydrogen-Ion Concentration; Iodoacetamide; Leucine; Metals, Heavy; Molecular Weight; Nymph; Phenylmethylsulfonyl Fluoride; Sequence Analysis, Protein; Sequence Homology, Amino Acid; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Sulfhydryl Compounds; Trypsin; Trypsin Inhibitors | 2003 |
Impact of cysteine proteinase inhibition in midgut fluid and oral secretion on fecundity and pollen consumption of western corn rootworm (Diabrotica virgifera virgifera).
Topics: Animals; Coleoptera; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Digestive System; Eating; Female; Fertility; Leucine; Leupeptins; Male; Oligopeptides; Pollen; Zea mays | 2003 |
Involvement of cysteine proteinases in excystment of Paragonimus ohirai metacercariae induced by sodium cholate and A23187.
Topics: Animals; Calcimycin; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Ionophores; Leucine; Leupeptins; Paragonimus; Parasitology; Reproduction; Serine Proteinase Inhibitors; Sodium Cholate | 2003 |
Enhancement of protease activity involved in modulation of cell mutability by microgravity stress in UVC-irradiated human cells.
Topics: Cell Line; Centrifugation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Endopeptidases; Humans; Hypergravity; Leucine; Mutagenesis; Ultraviolet Rays; Weightlessness | 2001 |
Invasion of melanoma cells into dermal connective tissue in vitro: evidence for an important role of cysteine proteases.
Topics: Cathepsins; Connective Tissue; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dermis; Extracellular Matrix; Humans; In Vitro Techniques; Leucine; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase Inhibitors; Melanoma; Neoplasm Invasiveness; Protease Inhibitors; Skin Neoplasms; Tumor Cells, Cultured | 2003 |
Inhibition of papain-like cysteine proteases and legumain by caspase-specific inhibitors: when reaction mechanism is more important than specificity.
Topics: Aldehydes; Amino Acid Chloromethyl Ketones; Animals; Caspase Inhibitors; Caspases; Cathepsins; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Jurkat Cells; Kinetics; Leucine; Liver; Oligopeptides; Papain; Rats; Substrate Specificity | 2003 |
The calpain-calpastatin system and the calcium paradox in the isolated perfused pigeon heart.
Topics: Animals; Antipain; Barium; Calcium; Calcium-Binding Proteins; Calpain; Cobalt; Columbidae; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethylmaleimide; Heart; In Vitro Techniques; Kinetics; Leucine; Leupeptins; Magnesium; Manganese; Molecular Weight; Myocardium; Nickel; Phenylmethylsulfonyl Fluoride; Strontium; Time Factors | 2003 |
Calpain inhibitors, a treatment for Alzheimer's disease: position paper.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Calpain; Cysteine Proteinase Inhibitors; Disease Models, Animal; Hippocampus; Leucine; Long-Term Potentiation; Maze Learning; Membrane Proteins; Memory Disorders; Mice; Mice, Transgenic; Organ Culture Techniques; Presenilin-1; Treatment Outcome; Up-Regulation | 2003 |
Excretory-secretory products secreted by Paragonimus westermani delay the spontaneous cell death of human eosinophils through autocrine production of GM-CSF.
Topics: Animals; Cell Death; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Eosinophils; Granulocyte-Macrophage Colony-Stimulating Factor; Helminth Proteins; Humans; Interleukin-3; Interleukin-5; Leucine; Lung Diseases; Paragonimiasis; Paragonimus; Tyrphostins | 2003 |
A cysteine protease from Taenia solium metacestodes induce apoptosis in human CD4+ T-cells.
Topics: Animals; Apoptosis; CD4-Positive T-Lymphocytes; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Kinetics; Leucine; Taenia solium | 2004 |
Colorado potato beetles show differential digestive compensatory responses to host plants expressing distinct sets of defense proteins.
Topics: Acetates; Animals; Arachidonic Acid; Body Weight; Coleoptera; Cyclopentanes; Cystatins; Digestive System; Endopeptidases; Host-Parasite Interactions; Larva; Leucine; Molting; Oxylipins; Plant Leaves; Plants, Genetically Modified; Protease Inhibitors; Recombinant Proteins; Solanum tuberosum; Tosyl Compounds | 2004 |
Effects of supplemental L-methionine on E-64 [trans-epoxysuccinyl-1-leucyl-amido (4-guanido) butane]-induced dysmorphology in rat embryos cultured in vitro.
Topics: Abnormalities, Drug-Induced; Animals; Culture Techniques; Embryonic and Fetal Development; Female; Leucine; Male; Methionine; Rats; Rats, Wistar; Teratogens | 2003 |
Insertion sequence 1 of muscle-specific calpain, p94, acts as an internal propeptide.
Topics: Amino Acid Sequence; Calcium; Calpain; Chelating Agents; Edetic Acid; Humans; Leucine; Leupeptins; Magnesium; Models, Molecular; Molecular Sequence Data; Nickel; Nitrilotriacetic Acid; Peptide Fragments; Protease Inhibitors; Protein Precursors; Protein Structure, Secondary; Protein Structure, Tertiary; Recombinant Proteins; Sequence Deletion; Transposases | 2004 |
Crystal structure of NS-134 in complex with bovine cathepsin B: a two-headed epoxysuccinyl inhibitor extends along the entire active-site cleft.
Topics: Animals; Binding Sites; Cathepsin B; Cattle; Crystallography, X-Ray; Cysteine Proteinase Inhibitors; Dipeptides; Epoxy Compounds; Kidney; Leucine; Molecular Conformation; Molecular Structure; Oligopeptides; Protein Binding; Protein Conformation; Protein Structure, Quaternary; Pyridines; Pyrroles | 2004 |
Cysteine proteases in Langerhans cells limits presentation of cartilage derived type II collagen for autoreactive T cells.
Topics: Animals; Antigen Presentation; Autoantigens; B-Lymphocytes; Cartilage; Collagen Type II; Cysteine Endopeptidases; Dendritic Cells; Genes, MHC Class II; Langerhans Cells; Leucine; Macrophages; Mice; Ovalbumin; Pepstatins; Peptides; Rats; T-Lymphocytes | 2004 |
The Leishmania chagasi proteasome: role in promastigotes growth and amastigotes survival within murine macrophages.
Topics: Acetylcysteine; Animals; Coumarins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Leishmania; Leishmaniasis, Visceral; Leucine; Macrophages, Peritoneal; Male; Mice; Multienzyme Complexes; Oligopeptides; Phenylmethylsulfonyl Fluoride; Proteasome Endopeptidase Complex | 2004 |
Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters.
Topics: Animals; Complement System Proteins; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electric Impedance; Entamoeba histolytica; Erythrocytes; Female; Histocytochemistry; Leucine; Liver Abscess, Amebic; Male; Phagocytosis | 2004 |
Role of cysteine proteinase of Entamoeba histolytica in target cell death.
Topics: Acetylgalactosamine; Animals; Apoptosis; Blotting, Northern; Cell Line; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytotoxicity, Immunologic; DNA Fragmentation; DNA, Protozoan; Dysentery, Amebic; Electrophoresis, Agar Gel; Electrophoresis, Polyacrylamide Gel; Entamoeba histolytica; Escherichia coli; Escherichia coli Infections; Leucine; Virulence | 2004 |
The role of Plasmodium falciparum food vacuole plasmepsins.
Topics: Amino Acids; Animals; Aspartic Acid Endopeptidases; Cell Cycle; Culture Media; Food; Genes, Protozoan; Leucine; Parasites; Pepstatins; Plasmodium falciparum; Vacuoles | 2005 |
Enzymatic characterization of a cubilin-related serine proteinase from the hard tick Haemaphysalis longicornis.
Topics: Animals; Antipain; Chromogenic Compounds; Escherichia coli; Fluorescent Dyes; Hydrogen-Ion Concentration; Ixodidae; Leucine; Leupeptins; Pepstatins; Phenylmethylsulfonyl Fluoride; Recombinant Proteins; Serine Endopeptidases; Serine Proteinase Inhibitors; Substrate Specificity; Temperature | 2004 |
Coordinate involvement of cysteine protease and nuclease in the executive phase of plant apoptosis.
Topics: Apoptosis; Aurintricarboxylic Acid; Avena; Cell Extracts; Cell Nucleus; Cell-Free System; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Plant; Drug Interactions; Endonucleases; Leucine; Protein Biosynthesis; Toxins, Biological | 2004 |
Proteasome proteolytic activity in hematopoietic cells from patients with chronic myeloid leukemia and multiple myeloma.
Topics: Apoptosis; Bone Marrow Cells; Cell Line, Tumor; Edetic Acid; Fusion Proteins, bcr-abl; Hematopoietic Stem Cells; HL-60 Cells; Humans; Leucine; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Multiple Myeloma; Neoplasm Proteins; Pepstatins; Protease Inhibitors; Proteasome Endopeptidase Complex; Recombinant Fusion Proteins; Sulfones; Transfection | 2004 |
Candida guilliermondii isolated from HIV-infected human secretes a 50 kDa serine proteinase that cleaves a broad spectrum of proteinaceous substrates.
Topics: Adult; AIDS-Related Opportunistic Infections; Blood Proteins; Brazil; Candida; Candidiasis; Enzyme Inhibitors; Extracellular Matrix Proteins; Gelatin; Humans; Hydrogen-Ion Concentration; Leucine; Lung Diseases, Fungal; Male; Molecular Weight; Pepstatins; Phenanthrolines; Phenylmethylsulfonyl Fluoride; Pneumonia; Serine Endopeptidases | 2005 |
The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion.
Topics: Amino Acid Sequence; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Immunoblotting; Immunoprecipitation; Leucine; Malaria; Molecular Sequence Data; Peptides; Plasmodium; Protozoan Proteins; Sporozoites; Virulence | 2005 |
Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides.
Topics: Cysteine Proteinase Inhibitors; Leucine; Magnetic Resonance Spectroscopy; Stereoisomerism | 2005 |
Assessment of the anthelmintic effect of natural plant cysteine proteinases against the gastrointestinal nematode, Heligmosomoides polygyrus, in vitro.
Topics: Actinidia; Ananas; Animals; Anthelmintics; Asclepias; Carica; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Ficus; Humans; Intestinal Diseases, Parasitic; Leucine; Male; Mice; Microscopy, Electron, Scanning; Nematoda; Nematode Infections; Papain; Plant Extracts; Plant Proteins | 2005 |
Inhibitors of calpain activation (PD150606 and E-64) and renal ischemia-reperfusion injury.
Topics: Acrylates; Animals; Calpain; Cathepsins; Cysteine Proteinase Inhibitors; Kidney; Leucine; Male; Rats; Rats, Wistar; Renal Circulation; Reperfusion Injury | 2005 |
A cysteine-activated protease isolated from Todarodes pacificus squid degrades collagen below its denaturation temperature.
Topics: Amino Acid Sequence; Animals; Cattle; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Decapodiformes; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Molecular Weight; Muscles; Octopodiformes; Protein Denaturation; Snails; Species Specificity; Temperature | 2004 |
Cladosporium Avr2 inhibits tomato Rcr3 protease required for Cf-2-dependent disease resistance.
Topics: Biotin; Cladosporium; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Extracellular Fluid; Fungal Proteins; Hydrogen-Ion Concentration; Immunoprecipitation; Leucine; Nicotiana; Pichia; Plant Diseases; Plant Leaves; Plant Proteins; Recombinant Fusion Proteins; Solanum lycopersicum | 2005 |
Carboxypeptidases cathepsins X and B display distinct protein profile in human cells and tissues.
Topics: Antibodies, Monoclonal; Antibody Specificity; Carboxypeptidases; Cathepsin B; Cathepsin K; Cathepsins; Cell Line, Tumor; Cell Movement; Collagen; Cysteine Proteinase Inhibitors; Cytosol; Dendritic Cells; Drug Combinations; Flow Cytometry; Humans; Immunohistochemistry; Laminin; Leucine; Lung; Lung Neoplasms; Lymph Nodes; Monocytes; Neoplasm Invasiveness; Proteoglycans; U937 Cells | 2005 |
Fasciola hepatica proteolytic activity in liver revealed by in situ zymography.
Topics: Animals; Cathepsin B; Cathepsins; Clinical Enzyme Tests; Cysteine Endopeptidases; Fasciola hepatica; Fascioliasis; Gelatin; Injections, Intraperitoneal; Leucine; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout | 2005 |
The Plasmodium falciparum cysteine protease falcipain-2 captures its substrate, hemoglobin, via a unique motif.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Antimalarials; Binding Sites; Caseins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Drug Design; Hemoglobins; Humans; Hydrolysis; Kinetics; Leucine; Macromolecular Substances; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Plasmodium falciparum; Protein Binding; Protein Folding; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Time Factors | 2005 |
The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition.
Topics: Ataxin-3; Dipeptides; DNA Repair Enzymes; DNA-Binding Proteins; Escherichia coli; Leucine; Machado-Joseph Disease; Models, Molecular; Nerve Tissue Proteins; Nitrogen Isotopes; Nuclear Magnetic Resonance, Biomolecular; Nuclear Proteins; Protein Structure, Tertiary; Repressor Proteins; Substrate Specificity | 2005 |
Endosomal proteolysis of insulin-like growth factor-I at its C-terminal D-domain by cathepsin B.
Topics: Catalysis; Cathepsin B; Cysteine Proteinase Inhibitors; Dipeptides; Endosomes; Humans; Insulin-Like Growth Factor I; Leucine; Protein Structure, Tertiary; Tumor Cells, Cultured | 2005 |
[Effects of MG132 , an inhibitor of proteasome , on the pollen germination and tube growth of Pecea wilsonii].
Topics: Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Leucine; Leupeptins; Microscopy; Picea; Pollen; Pollen Tube; Proteasome Inhibitors; Spectroscopy, Fourier Transform Infrared | 2005 |
Characterization of cathepsin L secreted by Sf21 insect cells.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Cathepsin L; Cathepsins; Cell Line; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Hydrogen-Ion Concentration; Kinetics; Leucine; Molecular Sequence Data; Spodoptera | 2005 |
Phytomonas serpens: cysteine peptidase inhibitors interfere with growth, ultrastructure and host adhesion.
Topics: Animals; Antibodies, Protozoan; Antipain; Cell Division; Cells, Cultured; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Detergents; Flow Cytometry; Heteroptera; Immunohistochemistry; Iodoacetamide; Leucine; Leupeptins; Membrane Proteins; Microscopy, Electron; Octoxynol; Plant Proteins; Polyethylene Glycols; Protozoan Proteins; Salivary Glands; Trypanosomatina | 2006 |
Partial characterization of a 29 kDa cysteine protease purified from Taenia solium metacestodes.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Collagen; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Immunoglobulin G; Iodoacetic Acid; Leucine; Serum Albumin, Bovine; Taenia solium | 2005 |
High-temperature liquid chromatography coupled on-line to a continuous-flow biochemical screening assay with electrospray ionization mass spectrometric detection.
Topics: Cathepsin B; Chromatography, Liquid; Dipeptides; Drug Stability; Hot Temperature; Leucine; Leupeptins; Online Systems; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tea | 2005 |
Dose-response inhibition of proteolytic activity by a cysteine protease inhibitor in a murine model of fasciolosis.
Topics: Animals; Cell Survival; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Fasciola hepatica; Fascioliasis; Fertility; Injections, Intraperitoneal; Leucine; Liver; Mice; Parasite Egg Count; Survival Analysis | 2006 |
Microinjection of an antibody against the cysteine-protease involved in male chromatin remodeling blocks the development of sea urchin embryos at the initial cell cycle.
Topics: Animals; Antibodies; Cell Cycle; Chromatin Assembly and Disassembly; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Replication; Embryonic Development; Fertilization; Immunoglobulins; Leucine; Male; Microinjections; Mitosis; Sea Urchins; Zygote | 2006 |
Pathogenicity of Vibrio penaeicida for white shrimp Litopenaeus vannamei: a cysteine protease-like exotoxin as a virulence factor.
Topics: Animals; Chromatography, Liquid; Copper; Cysteine Endopeptidases; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Hot Temperature; Lethal Dose 50; Leucine; Penaeidae; Vibrio; Virulence Factors | 2005 |
Critical roles for excretory-secretory cysteine proteases during tissue invasion of Paragonimus westermani newly excysted metacercariae.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Helminth; Dogs; Dose-Response Relationship, Drug; Gene Expression Regulation; Host-Parasite Interactions; Immunohistochemistry; Isoenzymes; Leucine; Life Cycle Stages; Mass Spectrometry; Mice; Molecular Sequence Data; Paragonimiasis; Paragonimus westermani; Peritoneum; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, Protein | 2006 |
Aspartic proteinases in the digestive tract of marine decapod crustaceans.
Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Proteinase Inhibitors; Decapoda; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Gastrointestinal Tract; Hydrogen-Ion Concentration; Leucine; Pepstatins; Protease Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Trypsin | 2006 |
Crucial commitment of proteolytic activity of a purified recombinant major house dust mite allergen Der p1 to sensitization toward IgE and IgG responses.
Topics: Animals; Antigens, Dermatophagoides; Arthropod Proteins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dermatophagoides pteronyssinus; Female; Hot Temperature; Hydrolysis; Immunization; Immunoglobulin E; Immunoglobulin G; Leucine; Mice; Mice, Inbred CBA; Protein Denaturation; Recombinant Proteins; Spleen | 2006 |
Characterization of HC58cDNA, a putative cysteine protease from the parasite Haemonchus contortus.
Topics: Animals; Caseins; Cathepsin B; Cysteine Proteinase Inhibitors; DNA, Complementary; Goat Diseases; Goats; Haemonchiasis; Haemonchus; Hemagglutination Tests; Hemoglobins; Hydrogen-Ion Concentration; Immunoglobulin G; Leucine; Recombinant Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Helminth | 2006 |
Altered gene expression in cells from patients with lysosomal storage disorders suggests impairment of the ubiquitin pathway.
Topics: Animals; Apoptosis; Cysteine Proteinase Inhibitors; Fibroblasts; Gene Expression Regulation, Enzymologic; Humans; Leucine; Lysosomal Storage Diseases; Mice; Oligonucleotide Array Sequence Analysis; Proteasome Endopeptidase Complex; RNA; RNA, Small Interfering; Signal Transduction; Skin; Ubiquitin; Ubiquitin Thiolesterase | 2007 |
Blood-brain barrier traversal by African trypanosomes requires calcium signaling induced by parasite cysteine protease.
Topics: Animals; Blood-Brain Barrier; Calcium; Calcium Signaling; Cathepsins; Cell Communication; Cell Movement; Cells, Cultured; Culture Media, Conditioned; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Dipeptides; Egtazic Acid; Endothelial Cells; Estrenes; Humans; Leucine; Naphthalenes; Phenylalanine; Piperazines; Protozoan Proteins; Pyrrolidinones; Tosyl Compounds; Trypanosoma; Trypanosoma brucei brucei; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Vinyl Compounds | 2006 |
[Hepatic amebiasis].
Topics: Animals; Cricetinae; Cysteine Proteinase Inhibitors; Entamoeba histolytica; Leucine; Liver; Liver Abscess, Amebic; Peptide Hydrolases | 2006 |
Babesia bovis: effects of cysteine protease inhibitors on in vitro growth.
Topics: Animals; Babesia bovis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Erythrocytes; Leucine; Leupeptins | 2007 |
Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus.
Topics: Acrosome Reaction; Animals; Female; Fertilization; Leucine; Leupeptins; Male; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sea Urchins; Sperm-Ovum Interactions; Spermatozoa; Ubiquitin; Vitelline Membrane | 2007 |
Nematicidal effects of cysteine proteinases against sedentary plant parasitic nematodes.
Topics: Actinidia; Ananas; Animals; Antinematodal Agents; Carica; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Leucine; Magnoliopsida; Microscopy, Electron, Scanning; Plant Extracts; Time Factors; Tylenchoidea | 2007 |
In vitro activity of the nonsteroidal anti-inflammatory drug indomethacin on a scuticociliate parasite of farmed turbot.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Protozoan; Ciliophora Infections; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Fragmentation; DNA, Protozoan; Fish Diseases; Fisheries; Flatfishes; Hydrolysis; Indomethacin; Leucine; Oligohymenophorea | 2007 |
Development of tier-I toxicity assays for Orius insidiosus (Heteroptera: Anthocoridae) for assessing the risk of plant-incorporated protectants to nontarget heteropterans.
Topics: Animals; Arsenicals; Heteroptera; Leucine; Plants, Genetically Modified; Pollen; Time Factors; Toxicity Tests | 2007 |
Cloning, site-directed mutagenesis and expression of cathepsin L-like cysteine protease from Uronema marinum (Ciliophora: Scuticociliatida).
Topics: Amino Acid Sequence; Animals; Cloning, Molecular; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA, Protozoan; Enzyme Stability; Escherichia coli; Gene Expression; Gene Library; Hydrogen-Ion Concentration; Leucine; Leupeptins; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligohymenophorea; Protein Folding; Protozoan Proteins; Recombinant Proteins; Sequence Analysis, DNA; Sequence Homology, Amino Acid | 2007 |
Evidence for processing enzymes in the abdominal gland of the newt, Cynops pyrrhogaster, that generate sodefrin from its biosynthetic precursor.
Topics: Amphibians; Animals; Hydrogen-Ion Concentration; Leucine; Male; Oligopeptides; Temperature | 2007 |
Molecular determination of laminin-5 degradation: a biomarker for mustard gas exposure diagnosis and its mechanism of action.
Topics: Biomarkers; Cell Adhesion Molecules; Cells, Cultured; Cysteine Proteinase Inhibitors; Dermatologic Agents; Environmental Exposure; Humans; Kalinin; Keratinocytes; Laminin; Leucine; Mustard Gas; Phenanthrolines; Protease Inhibitors; Serine Proteinase Inhibitors | 2008 |
Studies on synchronous egress of coccidian parasites (Neospora caninum, Toxoplasma gondii, Eimeria bovis) from bovine endothelial host cells mediated by calcium ionophore A23187.
Topics: Animals; Calcimycin; Cattle; Cattle Diseases; Coccidiosis; Cysteine Proteinase Inhibitors; Eimeria; Endothelial Cells; Ionophores; Leucine; Microscopy, Phase-Contrast; Neospora; Sarcocystidae; Toxoplasma | 2008 |
Protease activity of allergenic pollen of cedar, cypress, juniper, birch and ragweed.
Topics: Ambrosia; Antigens, Plant; Betula; Cryptomeria; Cupressus; Cysteine Endopeptidases; Humans; Japan; Juniperus; Leucine; Pollen; Radioallergosorbent Test; Rhinitis, Allergic, Seasonal; Serine Endopeptidases; Substrate Specificity; Sulfones | 2008 |
Plasmodium food vacuole plasmepsins are activated by falcipains.
Topics: Amino Acid Sequence; Animals; Aspartic Acid Endopeptidases; Cysteine Endopeptidases; Enzyme Activation; Kinetics; Leucine; Mass Spectrometry; Pepstatins; Peptide Fragments; Plasmodium falciparum; Vacuoles | 2008 |
Activity-based selection of a proteolytic species using ribosome display.
Topics: Aminoacyltransferases; Animals; Bacterial Proteins; Catalysis; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Leucine; Methods; Reverse Transcriptase Polymerase Chain Reaction; Ribosomes; RNA, Messenger | 2008 |
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment.
Topics: Animals; Blotting, Western; Culture Media; Cystatins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Flow Cytometry; Hemiptera; Hydrogen-Ion Concentration; Leucine; Leupeptins; Microscopy, Fluorescence; Protozoan Proteins; Reducing Agents; Salivary Proteins and Peptides; Solanum lycopersicum; Trypanosomatina | 2008 |
Cathepsin K regulates adipocyte differentiation: possible involvement of type I collagen degradation.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Animals; Cathepsin K; Cathepsins; CCAAT-Enhancer-Binding Proteins; Cell Differentiation; Collagen Type I; Cysteine Proteinase Inhibitors; Extracellular Matrix; Gene Expression Regulation; Leucine; Mice; PPAR gamma; Protein Processing, Post-Translational; Time Factors | 2009 |
Improvement of deficient natural killer activity and delayed bactericidal activity by a thiol proteinase inhibitor, E-64-d, in leukocytes from Chediak-Higashi syndrome patients in vitro.
Topics: Benzophenanthridines; Carbazoles; Cell Line, Tumor; Chediak-Higashi Syndrome; Cysteine Proteinase Inhibitors; Female; Humans; Killer Cells, Natural; Leucine; Male; Protein Kinase C; Protein Kinase Inhibitors; Staphylococcal Infections; Staphylococcus aureus | 2009 |
The comparison of parathyroid hormone degradation effect by various protease inhibitors in blood specimen.
Topics: Aprotinin; Blood Specimen Collection; Edetic Acid; Female; Humans; Leucine; Leupeptins; Male; Parathyroid Hormone; Protease Inhibitors; Time Factors | 2009 |
House dust mite allergen Der f 1 can induce the activation of latent TGF-beta via its protease activity.
Topics: Allergens; Animals; Antigens, Dermatophagoides; Arthropod Proteins; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Gene Expression; Leucine; Lung; Mice; Mice, Inbred BALB C; Pyroglyphidae; Signal Transduction; Smad Proteins; Transforming Growth Factor beta | 2009 |
Antiparasitic activity of cystine protease inhibitor E-64 against Giardia lamblia excystation in vitro and in vivo.
Topics: Animals; Cysteine Proteinase Inhibitors; Giardia lamblia; Giardiasis; Leucine; Mice | 2009 |
Intra- versus extracellular effects of microglia-derived cysteine proteases in a conditioned medium transfer model.
Topics: Analysis of Variance; Animals; Cathepsins; Cell Line, Transformed; Cell Line, Tumor; Culture Media, Conditioned; Cysteine Endopeptidases; Cytoplasm; Dipeptides; Enzyme Inhibitors; Leucine; Lipopolysaccharides; Lysosomes; Mice; Microglia; Neuroblastoma; Signal Transduction; Subcellular Fractions; Up-Regulation | 2009 |
Dissimilar peptidase production by avirulent and virulent promastigotes of Leishmania braziliensis: inference on the parasite proliferation and interaction with macrophages.
Topics: Animals; Cricetinae; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Host-Parasite Interactions; Leishmania braziliensis; Leucine; Macrophages, Peritoneal; Metalloendopeptidases; Mice; Mice, Inbred BALB C; Peptide Hydrolases; Phenanthrolines; Protease Inhibitors; Protozoan Proteins | 2009 |
Stimulation of fibroblast proliferation by the plant cysteine protease CMS2MS2 is independent of its proteolytic activity and requires ERK activation.
Topics: Animals; Butadienes; Carica; Cell Line; Cell Proliferation; Cysteine Proteases; Enzyme Activation; Fibroblasts; Flavonoids; Leucine; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogens; Nitriles; Protease Inhibitors; Protein Kinase Inhibitors; Type C Phospholipases | 2009 |
Cysteine proteinases from promastigotes of Leishmania (Viannia) braziliensis.
Topics: Animals; Cell Membrane; Cysteine Proteases; Cysteine Proteinase Inhibitors; Leishmania braziliensis; Leucine; Membrane Proteins; Microscopy, Confocal; Microscopy, Fluorescence; Molecular Weight; Protozoan Proteins | 2009 |
Hydrogen peroxide-induced apoptosis-like cell death in Entamoeba histolytica.
Topics: Animals; Apoptosis; Cysteine Proteases; Cysteine Proteinase Inhibitors; DNA Fragmentation; Entamoeba histolytica; Flow Cytometry; Humans; Hydrogen Peroxide; Leucine; Oxidative Stress; Reactive Oxygen Species; Trophozoites | 2010 |
A novel Ca2+-activated protease from germinating Vigna radiata seeds and its role in storage protein mobilization.
Topics: Calmodulin; Calpain; Chlorpromazine; Edetic Acid; Egtazic Acid; Enzyme Activation; Fabaceae; Germination; Leucine; Mercaptoethanol; Plant Proteins; Seeds; Serine Proteinase Inhibitors | 2010 |
Neoplastic progression of the human breast cancer cell line G3S1 is associated with elevation of cytoskeletal dynamics and upregulation of MT1-MMP.
Topics: Actins; Aprotinin; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Cytoskeleton; Dipeptides; Disease Progression; Female; Gelatin; Humans; Leucine; Marine Toxins; Matrix Metalloproteinase 14; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases, Secreted; Neoplasm Invasiveness; Neoplastic Stem Cells; Protease Inhibitors; Pseudopodia; Up-Regulation | 2010 |
Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence.
Topics: Analysis of Variance; Animals; Apoptosis; Blastocyst; Blotting, Western; Cathepsin B; Cattle; Cumulus Cells; Female; Immunohistochemistry; Leucine; Oocytes | 2010 |
Participation of cysteine protease cathepsin L in the gel disintegration of red bulleye (Priacanthus macracanthus) surimi gel paste.
Topics: Animals; Cathepsin L; Cysteine Proteases; Electrophoresis, Polyacrylamide Gel; Fish Products; Fish Proteins; Gels; Hot Temperature; Hydrolysis; Leucine; Leupeptins; Perciformes; Protease Inhibitors | 2010 |
Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain.
Topics: Animals; Calpain; Cysteine Proteinase Inhibitors; Demyelinating Diseases; Disease Models, Animal; Enzyme Activation; Leucine; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myelin-Associated Glycoprotein; Neurotoxins; Peripheral Nervous System Diseases; Receptors, Lysophosphatidic Acid; Sciatic Neuropathy; Sensory Receptor Cells; Spinal Nerve Roots | 2010 |
Alterations in osteoclast function and phenotype induced by different inhibitors of bone resorption--implications for osteoclast quality.
Topics: Animals; Bone Density Conservation Agents; Bone Resorption; Cattle; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; Diphosphonates; Enzyme Inhibitors; Humans; Ibandronic Acid; Leucine; Macrolides; Macrophage Colony-Stimulating Factor; Monocytes; Osteoclasts; Phenotype; Protease Inhibitors; RANK Ligand | 2010 |
Collagenolytic activity in sonic extracts of Tannerella forsythia.
Topics: Bacteroides; Calcium Chloride; Cathepsins; Cell Line, Tumor; Chelating Agents; Collagen Type I; Cysteine; Cysteine Proteinase Inhibitors; Edetic Acid; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Enzyme Inhibitors; Enzyme Precursors; Ethylmaleimide; Gelatinases; Humans; Iodoacetamide; Iodoacetic Acid; Leucine; Leupeptins; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Serine Proteinase Inhibitors; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone | 2010 |
Dentipain, a Streptococcus pyogenes IdeS protease homolog, is a novel virulence factor of Treponema denticola.
Topics: Amino Acid Sequence; Bacterial Proteins; Cysteine Proteinase Inhibitors; Leucine; Molecular Sequence Data; Sequence Alignment; Sequence Homology, Amino Acid; Serine Endopeptidases; Treponema denticola; Virulence Factors | 2010 |
Trypanosoma cruzi: insights into naphthoquinone effects on growth and proteinase activity.
Topics: Animals; Anti-Infective Agents; Chlorocebus aethiops; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Leucine; Naphthoquinones; Peptide Hydrolases; Protease Inhibitors; Protozoan Proteins; Trypanosoma cruzi; Vero Cells | 2011 |
Beneficial effects of cathepsin inhibition to prevent chemotherapy-induced intestinal mucositis.
Topics: Animals; Body Weight; Cathepsin D; Cathepsins; Chemokines, CXC; Eating; Gene Expression; Inflammation; Interleukin-1beta; Intestinal Mucosa; Leucine; Male; Methotrexate; Mucositis; Pepstatins; Peptide Hydrolases; Proteasome Endopeptidase Complex; Rats; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2010 |
Autolytic activity of human calpain 7 is enhanced by ESCRT-III-related protein IST1 through MIT-MIM interaction.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Biocatalysis; Blotting, Western; Calpain; Catalytic Domain; Cysteine Proteinase Inhibitors; Endosomal Sorting Complexes Required for Transport; Ethylmaleimide; Glutathione Transferase; Green Fluorescent Proteins; HEK293 Cells; Humans; Hydrolysis; Immunoprecipitation; Leucine; Leupeptins; Mutation; Oncogene Proteins; Protein Binding; Recombinant Fusion Proteins; Transfection | 2010 |
Microarray analysis reveals strategies of Tribolium castaneum larvae to compensate for cysteine and serine protease inhibitors.
Topics: Animals; Chymotrypsin; Cysteine Proteinase Inhibitors; Drug Combinations; Gene Expression Profiling; Glycine max; Larva; Leucine; Microarray Analysis; Serine Endopeptidases; Serine Proteinase Inhibitors; Tribolium; Trypsin Inhibitors | 2010 |
The surfactant lipid transporter ABCA3 is N-terminally cleaved inside LAMP3-positive vesicles.
Topics: ATP-Binding Cassette Transporters; Cell Line, Tumor; Cysteine Proteinase Inhibitors; Endothelium, Vascular; Glycosylation; Golgi Apparatus; Humans; Immunoblotting; Leucine; Luminescent Proteins; Lysosomal Membrane Proteins; Microscopy, Fluorescence; Molecular Weight; Multivesicular Bodies; Neoplasm Proteins; Pepstatins; Protein Folding; Protein Processing, Post-Translational | 2010 |
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin | 2011 |
Intracellular cathepsin B activity is inversely correlated with the quality and developmental competence of bovine preimplantation embryos.
Topics: Animals; Biomarkers; Blastocyst; Cathepsin B; Cattle; Cell Growth Processes; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Immunohistochemistry; In Situ Nick-End Labeling; Intracellular Space; Leucine; Male; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Fluoride does not inhibit enamel protease activity.
Topics: Ameloblasts; Amelogenesis; Animals; Cathepsin C; Cathepsin K; Cysteine Proteinase Inhibitors; Dental Enamel; Dental Enamel Proteins; Dipeptides; Dose-Response Relationship, Drug; Enamel Organ; Enzyme Inhibitors; Fluorides; Kallikreins; Leucine; Matrix Metalloproteinase 20; Matrix Metalloproteinase Inhibitors; Peptide Hydrolases; Protease Inhibitors; Serine Proteinase Inhibitors; Sulfones; Swine; Time Factors | 2011 |
Functional in vivo imaging of cysteine cathepsin activity in murine model of inflammation.
Topics: Animals; Anti-Inflammatory Agents; Cathepsins; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dexamethasone; Disease Models, Animal; Fluorescent Dyes; Indoles; Inflammation; Leucine; Male; Mice; Phenazines; Zymosan | 2011 |
Cysteine cathepsins in human carious dentin.
Topics: Adolescent; Adult; Age Factors; Cathepsin B; Cathepsins; Child; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dental Caries; Dental Pulp Exposure; Dentin; Fluorescent Dyes; Glycopeptides; Humans; Leucine; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Metalloendopeptidases; Middle Aged; Odontoblasts; Oligopeptides; Pepstatins; Protease Inhibitors; Saliva; Serine Proteinase Inhibitors; Spectrometry, Fluorescence; Young Adult | 2011 |
Identification and characterization of cysteine proteinases of Trypanosoma evansi.
Topics: Animals; Cysteine Proteases; Cysteine Proteinase Inhibitors; Enzyme Stability; Hydrogen-Ion Concentration; Immunoblotting; India; Leucine; Molecular Weight; Rabbits; Rats; Serum; Trypanosoma | 2011 |
Insecticidal effect of Canavalia ensiformis major urease on nymphs of the milkweed bug Oncopeltus fasciatus and characterization of digestive peptidases.
Topics: Amino Acid Sequence; Animals; Base Sequence; Canavalia; Cathepsin L; Chromatography, Ion Exchange; Coumarins; Cysteine Proteinase Inhibitors; Digestion; Dipeptides; Electrophoresis, Polyacrylamide Gel; Heteroptera; Hydrogen-Ion Concentration; Hydrolysis; Insecticides; Leucine; Molecular Sequence Data; Nymph; Peptide Fragments; Plant Proteins; Protein Precursors; Urease | 2011 |
Cysteine proteases in differentiation of embryonic stem cells into neural cells.
Topics: Animals; Antigens, Differentiation; Calpain; Cathepsin L; Cell Differentiation; Cell Line; Cell Surface Extensions; Coculture Techniques; Cystatin C; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Embryoid Bodies; Embryonic Stem Cells; Eye Proteins; GAP-43 Protein; Gene Expression; Homeodomain Proteins; Humans; Intermediate Filament Proteins; Leucine; Membrane Potentials; Mice; Nerve Tissue Proteins; Nestin; Neurofilament Proteins; Neurons; Nuclear Proteins; Paired Box Transcription Factors; PAX6 Transcription Factor; Repressor Proteins | 2011 |
Protease-mediated house dust mite allergen-induced reactive oxygen species production by neutrophils.
Topics: Adult; Antibodies, Anti-Idiotypic; Antigens, Dermatophagoides; Arthropod Proteins; Asthma; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Female; Humans; Immunoglobulin E; Leucine; Male; Middle Aged; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Peptide Hydrolases; Reactive Oxygen Species; Young Adult | 2011 |
Partial purification and characterisation of cysteine protease in wheat germ.
Topics: Caseins; Copper; Cysteine Proteases; Cysteine Proteinase Inhibitors; Enzyme Stability; Food-Processing Industry; Hydrogen-Ion Concentration; Industrial Waste; Iodoacetic Acid; Kinetics; Leucine; Molecular Weight; Plant Proteins; Seeds; Substrate Specificity; Temperature; Triticum | 2011 |
C-Terminal extension of a plant cysteine protease modulates proteolytic activity through a partial inhibitory mechanism.
Topics: Amino Acid Sequence; Biocatalysis; Computer Simulation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Precursors; Hot Temperature; Hydrogen-Ion Concentration; Hydrolysis; Isoenzymes; Kinetics; Leucine; Models, Molecular; Molecular Sequence Data; Plant Proteins; Protein Conformation; Protein Folding; Protein Stability; Recombinant Proteins | 2011 |
Serine protease inhibition reduces post-ischemic granulocyte recruitment in mouse intestine.
Topics: alpha-Macroglobulins; Animals; Benzamidines; Chemokines; Cysteine Proteinase Inhibitors; Granulocytes; Guanidines; Intestine, Small; Ischemia; Leucine; Male; Mice; Mice, Inbred C57BL; Peroxidase; Protease Inhibitors; Receptor, PAR-1; Receptor, PAR-2; Reperfusion Injury; Serine Proteinase Inhibitors; Trypsin | 2012 |
Prolonged signalling and trafficking of the bradykinin B2 receptor stimulated with the amphibian peptide maximakinin: insight into the endosomal inactivation of kinins.
Topics: Amphibian Venoms; Amphibians; Animals; Bradykinin; Cysteine Proteases; Down-Regulation; Endosomes; HEK293 Cells; Humans; Leucine; Macrolides; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase Kinases; Peptidyl-Dipeptidase A; Protein Transport; Proto-Oncogene Proteins c-fos; Rabbits; Receptor, Bradykinin B2; Recombinant Fusion Proteins; Signal Transduction | 2012 |
Chlorhexidine inhibits the activity of dental cysteine cathepsins.
Topics: Adult; Cathepsin B; Cathepsin K; Cathepsin L; Cathepsins; Chlorhexidine; Coumarins; Cysteine Proteinase Inhibitors; Dentin; Dipeptides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Dyes; Humans; Hydrolysis; Leucine; Matrix Metalloproteinase Inhibitors; Models, Molecular; Protein Binding; Protein Conformation; Recombinant Proteins; Spectrometry, Fluorescence; Young Adult | 2012 |
First-time report of metalloproteinases in fish bile and their potential as bioindicators regarding environmental contamination.
Topics: Animals; Bile; Biomarkers; Electrophoresis, Polyacrylamide Gel; Environmental Monitoring; Fishes; Leucine; Matrix Metalloproteinases; Phenylmethylsulfonyl Fluoride; Water Pollutants, Chemical | 2012 |
M6P/IGF2R modulates the invasiveness of liver cells via its capacity to bind mannose 6-phosphate residues.
Topics: Animals; Cell Line; Cell Movement; Cell Proliferation; Hepatocytes; Humans; Leucine; Liver Neoplasms; Lysosomes; Mannosephosphates; Mice; Neoplasm Invasiveness; Protein Binding; Rats; Receptor, IGF Type 2 | 2012 |
Leishmania (L.) amazonensis peptidase activities inside the living cells and in their lysates.
Topics: Amino Acid Sequence; Animals; Citrates; Cricetinae; Cysteine Proteinase Inhibitors; Hydrogen-Ion Concentration; Leishmania; Leucine; Mesocricetus; Oligopeptides; Pepstatins; Peptide Hydrolases; Proteolysis; Protozoan Proteins; Salinity; Serine Proteinase Inhibitors; Sodium Citrate; Sulfates; Temperature; Tosyllysine Chloromethyl Ketone | 2012 |
Cysteine peptidases, secreted by Trichomonas gallinae, are involved in the cytopathogenic effects on a permanent chicken liver cell culture.
Topics: Animals; Cells, Cultured; Chickens; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA Primers; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Hepatocytes; Leucine; Mass Spectrometry; Tosyllysine Chloromethyl Ketone; Trichomonas | 2012 |
Protease inhibitors decrease the resistance of Vitaceae to Plasmopara viticola.
Topics: Animals; Apoptosis; Cysteine Proteinase Inhibitors; Disease Resistance; Gene Expression Regulation, Plant; Host-Parasite Interactions; Leucine; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Oomycetes; Phenylmethylsulfonyl Fluoride; Plant Diseases; Plant Leaves; Plant Stomata; Protease Inhibitors; Serine Proteinase Inhibitors; Stilbenes; Vitaceae | 2012 |
Effect of phosphoric acid on the degradation of human dentin matrix.
Topics: Cathepsins; Collagen Type I; Collagenases; Cysteine Proteinase Inhibitors; Dentin; Dipeptides; Enzyme Activators; Enzyme Precursors; Humans; Leucine; Materials Testing; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peptide Hydrolases; Peptides; Phenylmercuric Acetate; Phosphoric Acids; Protein Denaturation; Sulfhydryl Reagents; Time Factors | 2013 |
Anti-serpin antibody-mediated regulation of proteases in autoimmune diabetes.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Neutralizing; Antigens, CD19; Autoantibodies; CD4 Antigens; Cysteine Proteinase Inhibitors; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Disease Progression; Female; Gene Expression; Immunity, Humoral; Interferon-gamma; Islets of Langerhans; Leucine; Lymph Nodes; Mice; Mice, Inbred NOD; Serpins; T-Lymphocytes | 2013 |
Development of an early-tier laboratory bioassay for assessing the impact of orally-active insecticidal compounds on larvae of Coccinella septempunctata (Coleoptera: Coccinellidae).
Topics: Animals; Aphids; Arsenates; Biological Assay; Coleoptera; Insecticides; Larva; Leucine; Moths; Ovum; Plants, Genetically Modified; Potassium Compounds; Risk Assessment | 2012 |
Anti-inflammatory activity of Bromelia hieronymi: comparison with bromelain.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Bromelains; Bromelia; Carrageenan; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Edema; Fruit; Leucine; Plant Extracts; Rats; Rats, Wistar | 2013 |
Enhancement of proteolytic activity of a thermostable papain-like protease by structure-based rational design.
Topics: Amino Acid Sequence; Amino Acid Substitution; Catalytic Domain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Activation; Enzyme Stability; Hydrogen-Ion Concentration; Kinetics; Leucine; Magnoliopsida; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Papain; Plant Proteins; Protein Binding; Protein Engineering; Proteolysis; Structural Homology, Protein | 2013 |
Conformational mobility of active and E-64-inhibited actinidin.
Topics: Amino Acid Sequence; Circular Dichroism; Cysteine Endopeptidases; Leucine; Models, Molecular; Molecular Dynamics Simulation; Molecular Sequence Data; Protein Conformation | 2013 |
Design, synthesis, and optimization of novel epoxide incorporating peptidomimetics as selective calpain inhibitors.
Topics: Calpain; Catalytic Domain; Click Chemistry; Computer Simulation; Drug Design; Epoxy Compounds; Kinetics; Leucine; Molecular Docking Simulation; Papain; Peptidomimetics; Stereoisomerism; Structure-Activity Relationship | 2013 |
Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation.
Topics: Animals; Apoptosis; Blastocyst; Cathepsin B; Cattle; Cumulus Cells; Cysteine Proteinase Inhibitors; Embryonic Development; Female; Fertilization in Vitro; Heat-Shock Response; Hot Temperature; In Situ Nick-End Labeling; Leucine; Oocytes; Ovarian Follicle; Pregnancy | 2013 |
Developing a rapid throughput screen for detection of nematicidal activity of plant cysteine proteinases: the role of Caenorhabditis elegans cystatins.
Topics: Animals; Antinematodal Agents; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carica; Cystatins; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Drug; Genes, Reporter; Latex; Leucine; Mutation; Organ Specificity; Plant Proteins; Recombinant Fusion Proteins; Temperature; Time Factors | 2014 |
Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis.
Topics: Amino Acids; Blotting, Western; Cysteine Proteinase Inhibitors; Glycine; Glyphosate; Herbicides; Hydroponics; Imidazoles; Leucine; Leupeptins; Oligopeptides; Pisum sativum; Plant Proteins; Plant Roots; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Time Factors | 2013 |
Differences in 53BP1 and BRCA1 regulation between cycling and non-cycling cells.
Topics: BRCA1 Protein; Cathepsin L; Cell Cycle Checkpoints; Cell Line; DNA Breaks, Double-Stranded; DNA End-Joining Repair; DNA Replication; Gene Expression Regulation; HeLa Cells; Humans; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Leucine; MCF-7 Cells; Radiation, Ionizing; RNA Interference; RNA, Small Interfering; Tumor Suppressor p53-Binding Protein 1 | 2013 |
Use of a dietary exposure system for screening of insecticidal compounds for their toxicity to the planthopper Laodelphax striatellus.
Topics: Animals; Arsenates; Bacillus thuringiensis; Cysteine Proteinase Inhibitors; Endotoxins; Enzyme-Linked Immunosorbent Assay; Female; Hemiptera; Insecticides; Larva; Leucine; Male; Nymph; Oryza; Plants, Genetically Modified; Potassium Compounds; Toxicity Tests | 2014 |
[Effect of different molarity cathepsins specific inhibitor E-64 on dentin-resin bonding durability].
Topics: Adolescent; Adult; Cathepsins; Collagen; Composite Resins; Dental Bonding; Dental Stress Analysis; Dentin; Dentin-Bonding Agents; Dose-Response Relationship, Drug; Humans; Leucine; Microscopy, Electron, Scanning; Molar, Third; Random Allocation; Tensile Strength; Young Adult | 2013 |
The thiol proteinase inhibitor E-64-d ameliorates amyloid-β-induced reduction of sAPPα secretion by reversing ceramide-induced protein kinase C down-regulation in SH-SY5Y neuroblastoma cells.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cell Line, Tumor; Cell Membrane Permeability; Ceramides; Down-Regulation; Humans; Isoenzymes; Leucine; Neuroblastoma; Peptide Fragments; Protease Inhibitors; Protein Kinase C; Sphingolipids; Sphingomyelin Phosphodiesterase | 2013 |
Selective conjugation of proteins by mining active proteomes through click-functionalized magnetic nanoparticles.
Topics: Azides; Biotin; Click Chemistry; Cysteine; Data Mining; Ferric Compounds; Leucine; Luminescence; Magnetics; Microwaves; Nanoparticles; Nanotechnology; Peptide Hydrolases; Plant Proteins; Proteome; Rhodamines; Spectroscopy, Fourier Transform Infrared; Streptavidin; Thermogravimetry | 2013 |
A cathepsin B inhibitor, E-64, improves the preimplantation development of bovine somatic cell nuclear transfer embryos.
Topics: Animals; Blastocyst; Cathepsin B; Cattle; Cysteine Proteinase Inhibitors; Embryo Culture Techniques; Embryo Implantation; Embryonic Development; Female; Leucine; Nuclear Transfer Techniques | 2014 |
Effects of midgut bacteria and two protease inhibitors on the reproductive potential and midgut enzymes of Culex pipiens infected with Wuchereria bancrofti.
Topics: Animals; Culex; Cysteine Proteinase Inhibitors; Edetic Acid; Female; Gastrointestinal Tract; Larva; Leucine; Reproduction; Wuchereria bancrofti | 2013 |
Effects of midgut bacteria and two protease inhibitors on the transmission of Wuchereria bancrofti by the mosquito vector, Culex pipiens.
Topics: Animals; Culex; Cysteine Proteinase Inhibitors; Edetic Acid; Female; Humans; Leucine; Wuchereria bancrofti | 2013 |
Preferential localization of γH2AX foci in euchromatin of retina rod cells after DNA damage induction.
Topics: Animals; Bleomycin; Cysteine Endopeptidases; DNA Breaks, Double-Stranded; DNA Repair; Euchromatin; Heterochromatin; Histones; Image Processing, Computer-Assisted; In Situ Nick-End Labeling; Leucine; Mice; Multigene Family; Phosphorylation; Retinal Rod Photoreceptor Cells | 2013 |
Grape marc extract causes early perception events, defence reactions and hypersensitive response in cultured tobacco cells.
Topics: Aprotinin; Cell Death; Cells, Cultured; Cycloheximide; Disease Resistance; Genes, Plant; Hydrogen-Ion Concentration; Leucine; Nicotiana; Pepstatins; Peptide Hydrolases; Plant Diseases; Plant Extracts; Plant Proteins; Up-Regulation; Vitis | 2014 |
Active actinidin retains function upon gastro-intestinal digestion and is more thermostable than the E-64-inhibited counterpart.
Topics: Actinidia; Allergens; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Digestion; Enzyme Stability; Leucine; Models, Biological | 2014 |
Inhibition of cathepsin B by E-64 induces oxidative stress and apoptosis in filarial parasite.
Topics: Animals; Apoptosis; Biomarkers; Cathepsin B; Filarioidea; Leucine; Oxidative Stress; Protease Inhibitors; Survival Analysis | 2014 |
Quantum mechanics/molecular mechanics studies of the mechanism of falcipain-2 inhibition by the epoxysuccinate E64.
Topics: Antimalarials; Catalytic Domain; Crystallography, X-Ray; Cysteine Endopeptidases; Humans; Leucine; Models, Chemical; Molecular Dynamics Simulation; Plasmodium falciparum; Quantum Theory | 2014 |
Intracellular MMP-2 activity in skeletal muscle is associated with type II fibers.
Topics: Animals; Cell Differentiation; Cell Line; Cysteine Proteinase Inhibitors; Edetic Acid; Gelatinases; Leucine; Male; Matrix Metalloproteinase 2; Mice; Mice, Inbred C57BL; Muscle Cells; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Myoblasts; Peptides, Cyclic; Physical Conditioning, Animal; Sarcomeres | 2015 |
Type-I interferons induce lung protease responses following respiratory syncytial virus infection via RIG-I-like receptors.
Topics: Adaptor Proteins, Signal Transducing; Adaptor Proteins, Vesicular Transport; Animals; Cathepsins; DEAD Box Protein 58; DEAD-box RNA Helicases; Gene Expression Regulation, Viral; Interferon Type I; Leucine; Lung; Matrix Metalloproteinases; Mice; Mice, Inbred Strains; Mice, Knockout; Phenylalanine; Respiratory Syncytial Virus Infections; Respiratory Syncytial Viruses; Ribavirin; Thiophenes; Viral Load | 2015 |
Effects of acid etching and adhesive treatments on host-derived cysteine cathepsin activity in dentin.
Topics: Acid Etching, Dental; Cathepsins; Chromogenic Compounds; Cysteine Proteases; Cysteine Proteinase Inhibitors; Dental Bonding; Dental Cements; Dentin; Dentin-Bonding Agents; Edetic Acid; Fluorescent Dyes; Humans; Leucine; Phosphoric Acids; Polymethacrylic Acids; Resin Cements | 2014 |
The anthelmintic efficacy of natural plant cysteine proteinases against Hymenolepis microstoma in vivo.
Topics: Animals; Anthelmintics; Carica; Cysteine Proteases; Humans; Hymenolepiasis; Hymenolepis; Latex; Leucine; Male; Mice; Mice, Inbred C3H | 2015 |
Combination of TRAIL with bortezomib shifted apoptotic signaling from DR4 to DR5 death receptor by selective internalization and degradation of DR4.
Topics: Amino Acid Chloromethyl Ketones; Apoptosis; Boronic Acids; Bortezomib; Cell Extracts; Drug Synergism; Endocytosis; HCT116 Cells; Humans; Leucine; Lysosomes; Macrolides; Proteolysis; Pyrazines; Receptors, Death Domain; Signal Transduction; Time Factors; TNF-Related Apoptosis-Inducing Ligand; Tumor Suppressor Protein p53 | 2014 |
Signaling pathways activated by a protease allergen in basophils.
Topics: Adaptor Protein Complex Subunits; Allergens; Animals; Basophils; Calcium Channel Blockers; Calcium Channels; Calcium Signaling; Cells, Cultured; Cysteine Proteinase Inhibitors; Gene Expression Regulation; Immunization; Interleukin-13; Interleukin-33; Interleukin-4; Interleukins; Leucine; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; NFATC Transcription Factors; Papain; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, IgE; Receptors, IgG; Signal Transduction; Specific Pathogen-Free Organisms | 2014 |
Characterization of the autophagy marker protein Atg8 reveals atypical features of autophagy in Plasmodium falciparum.
Topics: Adenine; Amino Acid Sequence; Antimalarials; Apicoplasts; Autophagy; Autophagy-Related Protein 8 Family; Chloroquine; Doxycycline; Erythrocytes; Gene Expression Regulation; Genome, Protozoan; Humans; Leucine; Life Cycle Stages; Microfilament Proteins; Molecular Sequence Data; Pepstatins; Plasmodium falciparum; Protease Inhibitors; Protozoan Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid | 2014 |
Consumption of Bt rice pollen containing Cry1C or Cry2A does not pose a risk to Propylea japonica (Thunberg) (Coleoptera: Coccinellidae).
Topics: Animals; Bacillus thuringiensis; Bacterial Proteins; Brassica rapa; Coleoptera; Larva; Leucine; Oryza; Plants, Genetically Modified; Pollen | 2015 |
Inhibition of cathepsin B activity reduces apoptosis by preventing cytochrome c release from mitochondria in porcine parthenotes.
Topics: Abattoirs; Animals; Apoptosis; Blastocyst; Caspase 3; Caspase 9; Caspase Inhibitors; Cathepsin B; Ectogenesis; Embryo Culture Techniques; Enzyme Repression; Female; In Vitro Oocyte Maturation Techniques; Leucine; Membrane Potential, Mitochondrial; Mitochondria; Nuclear Transfer Techniques; Oogenesis; Parthenogenesis; Republic of Korea; Sus scrofa | 2015 |
Characterization of Spirometra erinaceieuropaei Plerocercoid Cysteine Protease and Potential Application for Serodiagnosis of Sparganosis.
Topics: Animals; Blotting, Western; Cloning, Molecular; Cysteine Proteases; Enzyme-Linked Immunosorbent Assay; Hydrogen-Ion Concentration; Leucine; Mice; Neglected Diseases; Recombinant Proteins; Sensitivity and Specificity; Serologic Tests; Sparganosis; Sparganum; Spirometra; Temperature | 2015 |
A novel form of ficin from Ficus carica latex: Purification and characterization.
Topics: Chromatography, Gel; Cysteine Proteases; Cysteine Proteinase Inhibitors; Electrophoresis, Polyacrylamide Gel; Ficain; Ficus; Hydrogen-Ion Concentration; Latex; Leucine; Molecular Weight; Nuclear Magnetic Resonance, Biomolecular; Phenanthrolines; Polyethylene Glycols; Protein Structure, Secondary; Sulfhydryl Compounds | 2015 |
Cathepsin Protease Inhibition Reduces Endometriosis Lesion Establishment.
Topics: Adult; Animals; Cathepsins; Cysteine Proteinase Inhibitors; Endometriosis; Female; Humans; Leucine; Mice; Mice, Transgenic | 2016 |
Calpain-like: A Ca(2+) dependent cystein protease in Entamoeba histolytica cell death.
Topics: Amebicides; Amino Acid Sequence; Blotting, Western; Calcium; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Densitometry; DNA Fragmentation; Entamoeba histolytica; Gene Expression Regulation, Enzymologic; Gentamicins; In Situ Nick-End Labeling; Leucine; Leupeptins; Microscopy, Confocal; Molecular Sequence Data; Real-Time Polymerase Chain Reaction | 2015 |
Enzymatic and Structural Characterization of the Major Endopeptidase in the Venus Flytrap Digestion Fluid.
Topics: Animals; Caseins; Cattle; Chromatography, Liquid; Circular Dichroism; Cloning, Molecular; Crystallography, X-Ray; Cysteine Endopeptidases; Cysteine Proteases; Droseraceae; Drosophila melanogaster; Glycosylation; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Leucine; Lysine; Models, Molecular; Papain; Plant Proteins; Protein Folding; Protein Structure, Tertiary; Tandem Mass Spectrometry | 2016 |
Molecular characterization of a cathepsin F-like protease in Trichinella spiralis.
Topics: Animals; Cathepsin F; Cloning, Molecular; Cysteine Proteinase Inhibitors; Gene Expression; Gene Expression Profiling; Leucine; Protein Binding; Real-Time Polymerase Chain Reaction; Trichinella spiralis | 2015 |
A novel approach for reliable detection of cathepsin S activities in mouse antigen presenting cells.
Topics: Animals; Antigen-Presenting Cells; Cathepsins; Cells, Cultured; Cysteine Proteinase Inhibitors; Escherichia coli Infections; Fluorescent Dyes; Hydrolysis; Leucine; Mice, Knockout; Peptides; Reproducibility of Results; Spectrometry, Fluorescence; Substrate Specificity; Time Factors | 2016 |
Papain and its inhibitor E-64 reduce camelid semen viscosity without impairing sperm function and improve post-thaw motility rates.
Topics: Acrosome Reaction; Animals; Camelids, New World; Cell Survival; Cryopreservation; Cysteine Proteinase Inhibitors; DNA; Fructose; In Situ Nick-End Labeling; Kinetics; Lactose; Leucine; Male; New South Wales; Papain; Semen; Semen Analysis; Semen Preservation; Sperm Motility; Viscosity | 2017 |
ABT-737, a Bcl-2 Selective Inhibitor, and Chloroquine Synergistically Kill Renal Cancer Cells.
Topics: Amino Acid Chloromethyl Ketones; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Biphenyl Compounds; Carcinoma, Renal Cell; Cell Death; Cell Line, Tumor; Chloroquine; Drug Synergism; Humans; Kidney Neoplasms; Leucine; Nitrophenols; Oligopeptides; Piperazines; Proto-Oncogene Proteins c-bcl-2; Sulfonamides; Thiadiazoles | 2016 |
Differential cathepsin responses to inhibitor-induced feedback: E-64 and cystatin C elevate active cathepsin S and suppress active cathepsin L in breast cancer cells.
Topics: Breast Neoplasms; Cathepsin L; Cathepsins; Cell Line, Tumor; Cystatin C; Cytoplasm; Feedback, Physiological; Humans; Leucine; Protease Inhibitors; Protein Transport; Up-Regulation | 2016 |
Chronic cathepsin inhibition by E-64 in Dahl salt-sensitive rats.
Topics: Administration, Intravenous; Animals; Blood Pressure; Cathepsin L; Cathepsins; Cysteine Proteases; Cysteine Proteinase Inhibitors; Hypertension; Kidney Diseases; Leucine; Male; Rats; Rats, Inbred Dahl; Sodium; Sodium Chloride, Dietary | 2016 |
Co-distribution of cysteine cathepsins and matrix metalloproteases in human dentin.
Topics: Cathepsin K; Cathepsins; Cysteine; Dentin; Enzyme Assays; Epoxy Compounds; Humans; Immunohistochemistry; Kinetics; Leucine; Matrix Metalloproteinase Inhibitors; Matrix Metalloproteinases; Peptide Hydrolases; Tyrosine | 2017 |
Inhibition of lipopolysaccharide-induced osteoclast formation and bone resorption in vitro and in vivo by cysteine proteinase inhibitors.
Topics: Animals; Bone Density Conservation Agents; Bone Marrow Cells; Bone Resorption; Cathepsin K; Cystatin C; Cysteine Proteinase Inhibitors; Dose-Response Relationship, Immunologic; Gene Expression Regulation; Interleukin-6; Leucine; Lipopolysaccharides; Macrophages; Mice; NFATC Transcription Factors; Oligopeptides; Oncostatin M; Osteoclasts; Primary Cell Culture; Proto-Oncogene Proteins c-fos; RANK Ligand; Signal Transduction; Tartrate-Resistant Acid Phosphatase; Tumor Necrosis Factor-alpha | 2017 |
Laser-mediated rupture of chlamydial inclusions triggers pathogen egress and host cell necrosis.
Topics: Calpain; Cell Death; Chlamydia trachomatis; CRISPR-Cas Systems; Cysteine Proteinase Inhibitors; Gene Editing; Genes, Reporter; Green Fluorescent Proteins; HeLa Cells; Host-Pathogen Interactions; Humans; Laser Therapy; Leucine; Luminescent Proteins; Microscopy, Video; Necrosis; Red Fluorescent Protein; Time-Lapse Imaging | 2017 |
Cathepsin B inhibitor improves developmental competency and cryo-tolerance of in vitro ovine embryos.
Topics: Animals; Blastocyst; Cathepsin B; Cryopreservation; Cysteine Proteinase Inhibitors; Embryonic Development; Leucine; Sheep, Domestic | 2017 |
Respiratory syncytial virus (RSV) entry is inhibited by serine protease inhibitor AEBSF when present during an early stage of infection.
Topics: A549 Cells; Aprotinin; Cell Line; Cell Survival; Endopeptidases; Humans; Kinetics; Leucine; Pepstatins; Respiratory Syncytial Virus Infections; Respiratory Syncytial Virus, Human; Serine Proteinase Inhibitors; Sulfones; Time Factors; Tosylphenylalanyl Chloromethyl Ketone; Viral Proteins; Virus Internalization | 2017 |
Biochemical characterization of unusual cysteine protease of P. falciparum, metacaspase-2 (MCA-2).
Topics: Cysteine Proteases; Cysteine Proteinase Inhibitors; Dipeptides; Gene Expression Profiling; Ketones; Leucine; Plasmodium falciparum; Substrate Specificity | 2018 |
Heat-shock-induced cathepsin B activity during IVF and culture compromises the developmental competence of bovine embryos.
Topics: Animals; Blastocyst; Cathepsin B; Cattle; Cysteine Proteinase Inhibitors; Embryo Culture Techniques; Embryo, Mammalian; Embryonic Development; Fertilization in Vitro; Gene Expression Regulation, Enzymologic; Hot Temperature; Leucine | 2018 |
Rescue of CFTR NBD2 mutants N1303K and S1235R is influenced by the functioning of the autophagosome.
Topics: Aminopyridines; Animals; Autophagosomes; Autophagy; Benzodioxoles; Biological Transport; Blotting, Western; Cell Line; Cystic Fibrosis; Cystic Fibrosis Transmembrane Conductance Regulator; Electric Conductivity; Leucine; Mutant Proteins; Mutation; Small Molecule Libraries | 2018 |
Insertion sequence 1 from calpain-3 is functional in calpain-2 as an internal propeptide.
Topics: Calcium; Calcium-Binding Proteins; Calpain; Cysteine Proteinase Inhibitors; DNA Transposable Elements; Isoenzymes; Leucine; Leupeptins; Muscle Proteins; Protein Conformation; Proteolysis; Recombinant Proteins | 2018 |
Long-Term Cryopreservation and Revival of Tissue-Engineered Skeletal Muscle.
Topics: Animals; Biomechanical Phenomena; Cell Differentiation; Cell Line; Cell Survival; Cryopreservation; Extracellular Matrix; Freezing; Leucine; Mice; Muscle Fibers, Skeletal; Muscle, Skeletal; Proteolysis; Time Factors; Tissue Engineering | 2019 |
Insights into the tracking of the cysteine proteinase B COOH-terminal polypeptide of Leishmania (Leishmania) amazonensis by surface plasmon resonance.
Topics: Adaptation, Physiological; Animals; Antibodies, Protozoan; Cysteine Proteases; Cysteine Proteinase Inhibitors; Immunoglobulin G; Leishmania mexicana; Leishmaniasis, Cutaneous; Leucine; Mice; Mice, Inbred BALB C; Surface Plasmon Resonance | 2019 |
Effect of autophagy induction and cathepsin B inhibition on developmental competence of poor quality bovine oocytes.
Topics: Animals; Autophagy; Cathepsin B; Cattle; Cumulus Cells; Cysteine Proteinase Inhibitors; Embryonic Development; Female; Germinal Center; In Vitro Oocyte Maturation Techniques; Leucine; Oocytes; Sirolimus | 2020 |
Identification of a novel alkaline serine protease from gazami crab (Portunus trituberculatus) hepatopancreas and its hydrolysis of myofibrillar protein.
Topics: Animals; Brachyura; Cysteine Proteinase Inhibitors; Hepatopancreas; Leucine; Muscle Proteins; Pepstatins; Protease Inhibitors; Serine Endopeptidases | 2020 |
MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway.
Topics: Animals; Antiviral Agents; Bortezomib; Caspases; Chlorocebus aethiops; DNA Replication; Enzyme Activation; Gene Expression Regulation, Viral; Hep G2 Cells; Herpesvirus 1, Human; Humans; Leucine; Leupeptins; MAP Kinase Signaling System; Models, Biological; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polyubiquitin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Proteolysis; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Vero Cells; Virus Replication | 2020 |
In vitro effect of a novel protease inhibitor cocktail on Toxoplasma gondii tachyzoites.
Topics: Analysis of Variance; Animals; Aprotinin; Culture Media, Serum-Free; Cysteine Proteinase Inhibitors; Drug Combinations; Hep G2 Cells; Humans; Leucine; Leupeptins; Mice; Microscopy, Electron, Transmission; Organelles; Pilot Projects; Protease Inhibitors; Serine Proteinase Inhibitors; Statistics, Nonparametric; Sulfones; Toxoplasma | 2020 |
Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity.
Topics: Ananas; Antineoplastic Agents, Phytogenic; Bromelains; Catalytic Domain; Cell Line, Tumor; Cysteine; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Disulfides; Humans; Leucine; Models, Molecular; Plant Stems; Protein Conformation; Spectrometry, Mass, Electrospray Ionization; Substrate Specificity; Tosyllysine Chloromethyl Ketone | 2020 |
Effect of E-64 Supplementation during In Vitro Maturation on the Developmental Competence of Bovine OPU-Derived Oocytes.
Topics: Animals; Cathepsin B; Cattle; Dietary Supplements; Fertilization in Vitro; Leucine; Oocytes | 2022 |