Page last updated: 2024-09-03

e 64 and benzyloxycarbonylleucyl-leucyl-leucine aldehyde

e 64 has been researched along with benzyloxycarbonylleucyl-leucyl-leucine aldehyde in 13 studies

Compound Research Comparison

Studies
(e 64)
Trials
(e 64)
Recent Studies (post-2010)
(e 64)
Studies
(benzyloxycarbonylleucyl-leucyl-leucine aldehyde)
Trials
(benzyloxycarbonylleucyl-leucyl-leucine aldehyde)
Recent Studies (post-2010) (benzyloxycarbonylleucyl-leucyl-leucine aldehyde)
47711032,47331,057

Protein Interaction Comparison

ProteinTaxonomye 64 (IC50)benzyloxycarbonylleucyl-leucyl-leucine aldehyde (IC50)
Proteasome subunit beta type-11Homo sapiens (human)1.9893
Calpain-9Homo sapiens (human)9.88
Proteasome subunit alpha type-7Homo sapiens (human)1.9893
Replicase polyprotein 1abSevere acute respiratory syndrome-related coronavirus3.9
Replicase polyprotein 1abSevere acute respiratory syndrome coronavirus 23.8999
AromataseHomo sapiens (human)0.044
Indoleamine 2,3-dioxygenase 1Homo sapiens (human)0.5
Proteasome subunit beta type-1Homo sapiens (human)1.0853
Proteasome subunit alpha type-1Homo sapiens (human)1.9893
Proteasome subunit alpha type-2Homo sapiens (human)1.9893
Proteasome subunit alpha type-3Homo sapiens (human)1.9893
Proteasome subunit alpha type-4Homo sapiens (human)1.9893
Proteasome subunit beta type-8Homo sapiens (human)1.9893
Proteasome subunit beta type-9Homo sapiens (human)1.9893
Proteasome subunit alpha type-5Homo sapiens (human)1.9893
Proteasome subunit beta type-4Homo sapiens (human)1.9893
Proteasome subunit beta type-6Homo sapiens (human)1.9893
Proteasome subunit beta type-5Homo sapiens (human)0.6088
Proteasome subunit beta type-10Homo sapiens (human)1.9893
Proteasome subunit beta type-3Homo sapiens (human)1.9893
Proteasome subunit beta type-2Homo sapiens (human)2.0443
Proteasome subunit alpha type-6Homo sapiens (human)1.9893
Proteasome subunit alpha-type 8Homo sapiens (human)1.9893
Proteasome subunit beta type-7Homo sapiens (human)1.9893

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's4 (30.77)18.2507
2000's4 (30.77)29.6817
2010's3 (23.08)24.3611
2020's2 (15.38)2.80

Authors

AuthorsStudies
Abbenante, G; Fairlie, DP; Leung, D1
Dranchak, PK; Huang, R; Inglese, J; Lamy, L; Oliphant, E; Queme, B; Tao, D; Wang, Y; Xia, M1
Curtis, PV; Franch, HA; Mitch, WE1
Ancolio, K; Checler, F; da Costa, CA1
Azuma-Hara, M; Niinobe, M; Taniura, H; Uetsuki, T; Yoshikawa, K1
Asuru, A; Boudjelal, M; Fisher, GJ; Kang, S; Li, XY; Peng, ZH; Voorhees, JJ; Xiao, JH1
Justesen, J; Martensen, PM1
Hu, ZH; Sheng, XY1
Sawada, H; Yokota, N1
Bai, B; Jäämaa, S; Laiho, M; Latonen, L; Moore, HM1
Gil-Monreal, M; Royuela, M; van der Hoorn, RA; Villamor, JG; Zabalza, A; Zulet, A1
Fernández, TD; Flores, OM; García, CG; Maya, YC; Monroy, VS; Pérez Ishiwara, DG1
Fujimuro, M; Hosokawa, K; Ishimaru, H; Sugimoto, A; Tanaka, R; Watanabe, T1

Reviews

1 review(s) available for e 64 and benzyloxycarbonylleucyl-leucyl-leucine aldehyde

ArticleYear
Protease inhibitors: current status and future prospects.
    Journal of medicinal chemistry, 2000, Feb-10, Volume: 43, Issue:3

    Topics: Animals; Aspartic Acid Endopeptidases; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Humans; Metalloendopeptidases; Models, Molecular; Protease Inhibitors; Serine Endopeptidases; Serine Proteinase Inhibitors

2000

Other Studies

12 other study(ies) available for e 64 and benzyloxycarbonylleucyl-leucyl-leucine aldehyde

ArticleYear
In vivo quantitative high-throughput screening for drug discovery and comparative toxicology.
    Disease models & mechanisms, 2023, 03-01, Volume: 16, Issue:3

    Topics: Animals; Caenorhabditis elegans; Drug Discovery; High-Throughput Screening Assays; Humans; Proteomics; Small Molecule Libraries

2023
Mechanisms of renal tubular cell hypertrophy: mitogen-induced suppression of proteolysis.
    The American journal of physiology, 1997, Volume: 273, Issue:3 Pt 1

    Topics: Animals; Calpain; Cell Cycle; Cell Line; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Epidermal Growth Factor; Humans; Hypertrophy; Kidney Tubules, Proximal; Kinetics; Leucine; Leupeptins; Mitogens; Multienzyme Complexes; Proteasome Endopeptidase Complex; Proteins; Rabbits; Rats; Recombinant Proteins; Transforming Growth Factor beta

1997
C-terminal maturation fragments of presenilin 1 and 2 control secretion of APP alpha and A beta by human cells and are degraded by proteasome.
    Molecular medicine (Cambridge, Mass.), 1999, Volume: 5, Issue:3

    Topics: Acetylcysteine; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Enzyme Inhibitors; Glycopeptides; Humans; Leucine; Leupeptins; Membrane Proteins; Multienzyme Complexes; Oligopeptides; Pepstatins; Presenilin-1; Presenilin-2; Proteasome Endopeptidase Complex; Recombinant Proteins; Sulfones; Transfection

1999
Regulation and deregulation of E2F1 in postmitotic neurons differentiated from embryonal carcinoma P19 cells.
    Experimental cell research, 1999, Sep-15, Volume: 251, Issue:2

    Topics: Adenoviridae; Animals; Apoptosis; Carcinoma, Embryonal; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Cell Differentiation; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; E2F Transcription Factors; E2F1 Transcription Factor; Gene Expression Regulation; Gene Transfer Techniques; Genetic Vectors; Leucine; Leupeptins; Mice; Mitosis; Multienzyme Complexes; Neurons; Proteasome Endopeptidase Complex; Protein Processing, Post-Translational; Retinoblastoma-Binding Protein 1; RNA, Messenger; S Phase; Transcription Factor DP1; Transcription Factors; Tumor Cells, Cultured; Ubiquitins

1999
1,25-Dihydroxyvitamin D3 increases nuclear vitamin D3 receptors by blocking ubiquitin/proteasome-mediated degradation in human skin.
    Molecular endocrinology (Baltimore, Md.), 1999, Volume: 13, Issue:10

    Topics: Acetylcysteine; Administration, Topical; Calcitriol; Cells, Cultured; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Cytochrome P-450 Enzyme System; Dermatologic Agents; Gene Expression Regulation; Humans; Keratinocytes; Leucine; Leupeptins; Multienzyme Complexes; Phenylmethylsulfonyl Fluoride; Protease Inhibitors; Proteasome Endopeptidase Complex; Receptors, Calcitriol; Skin; Steroid Hydroxylases; Ubiquitins; Vitamin D3 24-Hydroxylase

1999
Specific inhibitors prevent proteolytic degradation of recombinant proteins expressed in High Five cells.
    BioTechniques, 2001, Volume: 30, Issue:4

    Topics: Animals; Baculoviridae; Cell Line; Cysteine Proteinase Inhibitors; Genetic Vectors; Insecta; Leucine; Leupeptins; Recombinant Proteins; Transfection

2001
[Effects of MG132 , an inhibitor of proteasome , on the pollen germination and tube growth of Pecea wilsonii].
    Shi yan sheng wu xue bao, 2005, Volume: 38, Issue:4

    Topics: Cysteine Proteinase Inhibitors; Dimethyl Sulfoxide; Leucine; Leupeptins; Microscopy; Picea; Pollen; Pollen Tube; Proteasome Inhibitors; Spectroscopy, Fourier Transform Infrared

2005
Sperm proteasomes are responsible for the acrosome reaction and sperm penetration of the vitelline envelope during fertilization of the sea urchin Pseudocentrotus depressus.
    Developmental biology, 2007, Aug-01, Volume: 308, Issue:1

    Topics: Acrosome Reaction; Animals; Female; Fertilization; Leucine; Leupeptins; Male; Protease Inhibitors; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Sea Urchins; Sperm-Ovum Interactions; Spermatozoa; Ubiquitin; Vitelline Membrane

2007
Proteasome inhibitors induce nucleolar aggregation of proteasome target proteins and polyadenylated RNA by altering ubiquitin availability.
    Oncogene, 2011, Feb-17, Volume: 30, Issue:7

    Topics: Acetylcysteine; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Cell Nucleolus; Checkpoint Kinase 1; Cyclin-Dependent Kinases; Cyclins; Cysteine Proteinase Inhibitors; DNA-Binding Proteins; Humans; Leucine; Leupeptins; Nuclear Proteins; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; RNA, Messenger; Transcription Factors; Tumor Suppressor Proteins; Ubiquitin

2011
Proteolytic pathways induced by herbicides that inhibit amino acid biosynthesis.
    PloS one, 2013, Volume: 8, Issue:9

    Topics: Amino Acids; Blotting, Western; Cysteine Proteinase Inhibitors; Glycine; Glyphosate; Herbicides; Hydroponics; Imidazoles; Leucine; Leupeptins; Oligopeptides; Pisum sativum; Plant Proteins; Plant Roots; Proteasome Endopeptidase Complex; Proteolysis; Signal Transduction; Time Factors

2013
Calpain-like: A Ca(2+) dependent cystein protease in Entamoeba histolytica cell death.
    Experimental parasitology, 2015, Volume: 159

    Topics: Amebicides; Amino Acid Sequence; Blotting, Western; Calcium; Calpain; Cysteine Endopeptidases; Cysteine Proteinase Inhibitors; Densitometry; DNA Fragmentation; Entamoeba histolytica; Gene Expression Regulation, Enzymologic; Gentamicins; In Situ Nick-End Labeling; Leucine; Leupeptins; Microscopy, Confocal; Molecular Sequence Data; Real-Time Polymerase Chain Reaction

2015
MG132 exerts anti-viral activity against HSV-1 by overcoming virus-mediated suppression of the ERK signaling pathway.
    Scientific reports, 2020, 04-21, Volume: 10, Issue:1

    Topics: Animals; Antiviral Agents; Bortezomib; Caspases; Chlorocebus aethiops; DNA Replication; Enzyme Activation; Gene Expression Regulation, Viral; Hep G2 Cells; Herpesvirus 1, Human; Humans; Leucine; Leupeptins; MAP Kinase Signaling System; Models, Biological; NF-kappa B; NF-KappaB Inhibitor alpha; Phosphorylation; Polyubiquitin; Proteasome Endopeptidase Complex; Proteasome Inhibitors; Protein Stability; Proteolysis; Tosyllysine Chloromethyl Ketone; Tosylphenylalanyl Chloromethyl Ketone; Vero Cells; Virus Replication

2020