Compounds > e 4031

e 4031 and l 706000

e 4031 has been researched along with l 706000 in 5 studies

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's3 (60.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bianucci, AM; Calderone, V; Coi, A; Massarelli, I; Testai, L1
Baskin, EP; Lynch, JJ1
Curran, ME; Keating, MT; Sanguinetti, MC; Spector, PS1
Callaghan, BP; Farrelly, AM; Fleming, N; Horowitz, B; Keef, KD; Khoyi, MA; Ro, S; Sanders, KM1
de Groot, MJ; Helliwell, R; Leishman, D; Mitcheson, J; Perry, M; Sanguinetti, MC; Tristani-Firouzi, M1

Other Studies

5 other study(ies) available for e 4031 and l 706000

ArticleYear
Identification of "toxicophoric" features for predicting drug-induced QT interval prolongation.
    European journal of medicinal chemistry, 2008, Volume: 43, Issue:11

    Topics: Amino Acid Sequence; Heart; Humans; Models, Molecular; Molecular Sequence Data; Molecular Structure; Protein Subunits; Sequence Alignment; Structure-Activity Relationship; Trans-Activators; Transcriptional Regulator ERG

2008
Comparative effects of increased extracellular potassium and pacing frequency on the class III activities of methanesulfonanilide IKr blockers dofetilide, D-sotalol, E-4031, and MK-499.
    Journal of cardiovascular pharmacology, 1994, Volume: 24, Issue:2

    Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Electric Stimulation; Ferrets; Male; Phenethylamines; Piperidines; Potassium; Potassium Channel Blockers; Pyridines; Refractory Period, Electrophysiological; Sotalol; Sulfonamides

1994
Class III antiarrhythmic drugs block HERG, a human cardiac delayed rectifier K+ channel. Open-channel block by methanesulfonanilides.
    Circulation research, 1996, Volume: 78, Issue:3

    Topics: Animals; Anti-Arrhythmia Agents; Benzopyrans; Cation Transport Proteins; Cells, Cultured; DNA-Binding Proteins; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Ion Channel Gating; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Trans-Activators; Transcriptional Regulator ERG; Xenopus

1996
Expression and function of KCNH2 (HERG) in the human jejunum.
    American journal of physiology. Gastrointestinal and liver physiology, 2003, Volume: 284, Issue:6

    Topics: Acetylcholine; Alternative Splicing; Amino Acid Sequence; Base Sequence; Benzopyrans; Calcium Channels; Cation Transport Proteins; DNA-Binding Proteins; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Gene Expression Regulation; Humans; In Vitro Techniques; Jejunum; Membrane Potentials; Muscle Contraction; Muscle, Smooth; Piperidines; Potassium; Potassium Channels; Potassium Channels, Voltage-Gated; Potassium Chloride; Pyridines; RNA, Messenger; Sequence Alignment; Time Factors; Trans-Activators; Transcriptional Regulator ERG

2003
Structural determinants of HERG channel block by clofilium and ibutilide.
    Molecular pharmacology, 2004, Volume: 66, Issue:2

    Topics: Amino Acid Substitution; Animals; Anti-Arrhythmia Agents; Aspartic Acid; Benzopyrans; Binding Sites; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Kinetics; Models, Molecular; Mutagenesis, Site-Directed; Oocytes; Phenethylamines; Phenylalanine; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Quaternary Ammonium Compounds; Serine; Sulfonamides; Tyrosine; Xenopus laevis

2004