e 4031 has been researched along with 4-aminopyridine in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD | 1 |
| Sen, S; Sinha, N | 1 |
| Giles, WR; Habuchi, Y; Imaizumi, Y; Muraki, K; Watanabe, M | 1 |
| Chiba, S; Furukawa, Y; Kasama, M; Oguchi, T; Sawaki, S | 1 |
| Ishii, K; Taira, N; Yamagishi, T | 1 |
| Carrier, M; Feng, J; Li, GR; Nattel, S; Yue, L | 1 |
| Boyden, PA; Pinto, JM | 1 |
| Kubota, I; Tachibana, H; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Kubota, I; Miyashita, T; Tomoike, H; Watanabe, T; Yamaki, M; Yamauchi, S | 1 |
| Fukuda, K; Kato, T; Kodama, H; Miyoshi, S; Ogawa, S; Tahara, S | 1 |
| Kobayashi, S; Masuda, Y; Nakaya, H; Ogura, T; Reien, Y; Saito, T | 1 |
| Imai, T; Koike, K; Okamoto, T; Shigenobu, K; Tanaka, H; Tanaka, Y; Yamamoto, Y | 1 |
| Arulkumaran, S; Hill, SJ; Khan, RN; Liu, B | 1 |
| Pan, YP; Wang, XL; Xu, XH | 1 |
| Belardinelli, L; January, CT; Li, H; Rajamani, S; Shryock, JC; Wu, L | 1 |
| Bauriedl, J; Bussek, A; Lohmann, H; Ravens, U; Schmidt, M; Wettwer, E | 1 |
16 other study(ies) available for e 4031 and 4-aminopyridine
| Article | Year |
|---|---|
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical | 2004 |
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship | 2011 |
Delayed rectifier K+ current in rabbit atrial myocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Atrial Function; Electrophysiology; Kinetics; Myocardium; Piperidines; Potassium; Pyridines; Rabbits; Time Factors | 1995 |
Are negative chronotropic and inotropic responses to adenosine differentiated at the receptor or postreceptor levels in isolated dog hearts?
Topics: 2-Chloroadenosine; 4-Aminopyridine; Adenosine; Adenosine-5'-(N-ethylcarboxamide); Animals; Benzazepines; Depression, Chemical; Dogs; Heart Rate; In Vitro Techniques; Myocardial Contraction; Piperidines; Pyridines; Receptors, Purinergic P1; Xanthines | 1995 |
Absence of effects of class III antiarrhythmic agents on cloned cardiac K channels.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Cloning, Molecular; Electrophysiology; Myocardium; Oocytes; Piperidines; Potassium Channels; Pyridines; Pyrimidinones; Quinidine; Sotalol; Xenopus laevis | 1993 |
Evidence for two components of delayed rectifier K+ current in human ventricular myocytes.
Topics: 4-Aminopyridine; Action Potentials; Adult; Anti-Arrhythmia Agents; Diuretics; Electric Conductivity; Heart Ventricles; Humans; Indapamide; Middle Aged; Myocardium; Piperidines; Potassium; Potassium Channels; Pyridines; Reaction Time; Ventricular Function | 1996 |
Reduced inward rectifying and increased E-4031-sensitive K+ current density in arrhythmogenic subendocardial purkinje myocytes from the infarcted heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channel Blockers; Cesium; Data Interpretation, Statistical; Dogs; In Vitro Techniques; Male; Membrane Potentials; Myocardial Infarction; Patch-Clamp Techniques; Piperidines; Potassium Channels; Purkinje Cells; Pyridines | 1998 |
Intracoronary flecainide induces ST alternans and reentrant arrhythmia on intact canine heart: A role of 4-aminopyridine-sensitive current.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Coronary Vessels; Disopyramide; Dogs; Electrocardiography; Flecainide; Injections; Lidocaine; Piperidines; Pyridines; Sodium Channels; Ventricular Fibrillation; Verapamil | 1999 |
4-aminopyridine inhibits the occurrence of ventricular fibrillation but not ventricular tachycardia in the reperfused, P6olated rat heart.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Blood Flow Velocity; Glyburide; Heart; Heart Rate; In Vitro Techniques; Male; Myocardial Reperfusion; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Tachycardia, Ventricular; Torsades de Pointes; Ventricular Fibrillation; Verapamil | 2000 |
Potassium channel blocker activates extracellular signal-regulated kinases through Pyk2 and epidermal growth factor receptor in rat cardiomyocytes.
Topics: 4-Aminopyridine; Action Potentials; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Calcium Channels, L-Type; Cells, Cultured; Cytochalasin D; Drug Evaluation, Preclinical; ErbB Receptors; Focal Adhesion Kinase 2; Mitogen-Activated Protein Kinases; Myocardium; Phosphorylation; Piperidines; Potassium Channel Blockers; Protein-Tyrosine Kinases; Pyridines; Quinazolines; Quinidine; Rats; Rats, Wistar; Tetraethylammonium; Time Factors; Tyrphostins | 2001 |
Inhibitory effect of bepridil on hKv1.5 channel current: comparison with amiodarone and E-4031.
Topics: 4-Aminopyridine; Action Potentials; Amiodarone; Animals; Anti-Arrhythmia Agents; Atrial Function; Bepridil; Dose-Response Relationship, Drug; Gene Expression; Heart Atria; Humans; In Vitro Techniques; Kv1.5 Potassium Channel; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyridines; Rats | 2001 |
Effects of different types of K+ channel modulators on the spontaneous myogenic contraction of guinea-pig urinary bladder smooth muscle.
Topics: 4-Aminopyridine; Animals; Anti-Arrhythmia Agents; Apamin; Barium; Benzimidazoles; Calcium Channel Blockers; Cation Transport Proteins; Cromakalim; Diltiazem; Ether-A-Go-Go Potassium Channels; Female; Glyburide; Guinea Pigs; Large-Conductance Calcium-Activated Potassium Channels; Male; Muscle Contraction; Muscle, Smooth; Nisoldipine; Parasympatholytics; Peptides; Periodicity; Piperidines; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Calcium-Activated; Potassium Channels, Voltage-Gated; Pyridines; Small-Conductance Calcium-Activated Potassium Channels; Urinary Bladder | 2001 |
Comparison of potassium currents in human decidua before and after the onset of labor.
Topics: 4-Aminopyridine; Adult; Cesarean Section; Decidua; Delivery, Obstetric; Female; Fluorescent Antibody Technique; Humans; Labor Onset; Membrane Potentials; Parturition; Patch-Clamp Techniques; Piperidines; Potassium; Potassium Channel Blockers; Potassium Channels; Pregnancy; Pyridines; Stromal Cells; Tetraethylammonium Compounds; Thy-1 Antigens | 2003 |
[High throughput screening method of potassium channel regulators].
Topics: 4-Aminopyridine; Animals; Barbiturates; Calcium Channel Blockers; Cromakalim; Isoxazoles; Membrane Potentials; Nifedipine; Patch-Clamp Techniques; PC12 Cells; Piperidines; Potassium Channel Blockers; Potassium Channels; Pyridines; Quinidine; Rats | 2004 |
Reduction of repolarization reserve unmasks the proarrhythmic role of endogenous late Na(+) current in the heart.
Topics: 4-Aminopyridine; Acetanilides; Action Potentials; Animals; Anti-Arrhythmia Agents; Barium Compounds; Cell Line; Chlorides; Enzyme Inhibitors; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Female; Heart Conduction System; Humans; Kidney; Patch-Clamp Techniques; Piperazines; Piperidines; Potassium Channel Blockers; Pyridines; Rabbits; Ranolazine; Sodium; Sodium Channel Blockers; Sodium Channels; Tachycardia, Ventricular; Tetrodotoxin; Torsades de Pointes | 2009 |
Cardiac tissue slices with prolonged survival for in vitro drug safety screening.
Topics: 4-Aminopyridine; Action Potentials; Animal Testing Alternatives; Animals; Animals, Laboratory; Anti-Arrhythmia Agents; Calcium Channel Blockers; Carbenoxolone; Disease Models, Animal; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Guinea Pigs; Heart Ventricles; In Vitro Techniques; Male; Nifedipine; Piperidines; Potassium Channel Blockers; Pyridines; Rats; Rats, Wistar; Risk Assessment; Toxicity Tests | 2012 |