Page last updated: 2024-09-02

dynorphin (1-8) and naltrexone

dynorphin (1-8) has been researched along with naltrexone in 15 studies

Compound Research Comparison

Studies
(dynorphin (1-8))
Trials
(dynorphin (1-8))
Recent Studies (post-2010)
(dynorphin (1-8))
Studies
(naltrexone)
Trials
(naltrexone)
Recent Studies (post-2010) (naltrexone)
173038,7451,2282,642

Protein Interaction Comparison

ProteinTaxonomydynorphin (1-8) (IC50)naltrexone (IC50)
Cytochrome P450 2D6Homo sapiens (human)1
Delta-type opioid receptorMus musculus (house mouse)0.0051
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0063
Kappa-type opioid receptorMus musculus (house mouse)0.006
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0005
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0005
Mu-type opioid receptorHomo sapiens (human)0.006
Delta-type opioid receptorHomo sapiens (human)0.0319
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0093
Kappa-type opioid receptorHomo sapiens (human)0.0377
Mu-type opioid receptorMus musculus (house mouse)0.0076
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0004

Research

Studies (15)

TimeframeStudies, this research(%)All Research%
pre-19903 (20.00)18.7374
1990's10 (66.67)18.2507
2000's2 (13.33)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ingenito, AJ; Wang, JQ3
Barnes, MI; Hong, JS; Hudson, PM; Mitchell, CL1
Koehler, E; McLemore, GL; Rosella-Dampman, LM; Summy-Long, JY1
Dixon, DM; Traynor, JR1
McLean, S; Rothman, RB1
Schwyzer, R1
Herz, A; Schulz, R; Wüster, M1
Lookingland, KJ; Manzanares, J; Moore, KE; Wagner, EJ1
Dewey, WL; Smith, FL1
Hong, JS; Hudson, PM; Jin, L; Kong, LY; McMillian, MK1
Goldstein, BD; Zachariou, V1
Ballet, S; Bourgoin, S; Braz, J; Cesselin, F; Hamon, M; Mauborgne, A; Zajac, JM1
Gallo, RV; Zhang, Q1

Other Studies

15 other study(ies) available for dynorphin (1-8) and naltrexone

ArticleYear
Centrally mediated cardiovascular actions of dynorphin A(1-8) on rat hippocampal formation.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 261, Issue:2

    Topics: Animals; Blood Pressure; Dynorphins; Heart Rate; Hippocampus; Injections, Intraventricular; Lidocaine; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Respiration

1992
Opioid mu and delta receptor antagonists reduce wet dog shaking elicited by perforant path stimulation.
    Pharmacology, biochemistry, and behavior, 1991, Volume: 38, Issue:4

    Topics: Animals; Dynorphins; Electric Stimulation; Enkephalin, Leucine; Enkephalin, Methionine; gamma-Aminobutyric Acid; Hippocampus; Male; Naltrexone; Peptide Fragments; Rats; Rats, Inbred F344; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, mu; Stereotyped Behavior

1991
Kappa opiate receptors inhibit release of oxytocin from the magnocellular system during dehydration.
    Neuroendocrinology, 1990, Volume: 51, Issue:4

    Topics: Animals; Benzomorphans; Dehydration; Dynorphins; Endorphins; Hypertonic Solutions; Injections, Intraventricular; Male; Naloxone; Naltrexone; Narcotic Antagonists; Neurons; Osmolar Concentration; Oxytocin; Peptide Fragments; Pituitary Gland, Posterior; Protein Precursors; Radioimmunoassay; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, kappa; Vasopressins

1990
Evidence that the agonist action of dynorphin A(1-8) in the guinea-pig myenteric-plexus may be mediated partly through conversion to [Leu5]enkephalin.
    British journal of pharmacology, 1990, Volume: 101, Issue:3

    Topics: Animals; Dynorphins; Enkephalin, Leucine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Muscle Contraction; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Peptide Fragments; Receptors, Opioid

1990
An examination of the opiate receptor subtypes labeled by [3H]cycloFOXY: an opiate antagonist suitable for positron emission tomography.
    Biological psychiatry, 1988, Mar-01, Volume: 23, Issue:5

    Topics: Animals; Autoradiography; Brain; Dynorphins; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Male; Naloxone; Naltrexone; Peptide Fragments; Rats; Rats, Inbred Strains; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Synaptic Membranes; Tomography, Emission-Computed

1988
Estimated membrane structure and receptor subtype selection of an opioid alkaloid-peptide hybrid.
    International journal of peptide and protein research, 1988, Volume: 32, Issue:6

    Topics: Animals; Brain; Cell Membrane; Dynorphins; Guinea Pigs; Kinetics; Naltrexone; Peptide Fragments; Receptors, Opioid; Substrate Specificity

1988
Receptor preference of dynorphin A fragments in the mouse vas deferens determined by different techniques.
    The Journal of pharmacology and experimental therapeutics, 1984, Volume: 230, Issue:1

    Topics: Animals; Drug Tolerance; Dynorphins; Endorphins; Enkephalin, Leucine; Enkephalin, Leucine-2-Alanine; Fentanyl; Male; Mice; Naloxone; Naltrexone; Peptide Fragments; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Vas Deferens

1984
Neurochemical evidence that estrogen-induced suppression of kappa-opioid-receptor-mediated regulation of tuberoinfundibular dopaminergic neurons is prolactin-independent.
    Neuroendocrinology, 1994, Volume: 59, Issue:3

    Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Brain Chemistry; Dopamine; Dynorphins; Estrogens; Female; Hydrazines; Hypothalamic Hormones; Injections, Intraventricular; Median Eminence; Naltrexone; Nerve Endings; Neurons; Ovariectomy; Peptide Fragments; Prolactin; Rats; Receptors, Opioid, kappa

1994
Cardiovascular effects of microinjection of dynorphin-A(1-8) into the hippocampus in conscious, spontaneously hypertensive and normotensive Wistar-Kyoto rats.
    Clinical and experimental hypertension (New York, N.Y. : 1993), 1994, Volume: 16, Issue:2

    Topics: Animals; Blood Pressure; Cardiovascular System; Dose-Response Relationship, Drug; Dynorphins; Hippocampus; Hypertension; Male; Microinjections; Naltrexone; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY

1994
Cardiovascular responses to intra-hippocampal dynorphin A-(1-8) in spontaneously hypertensive rats.
    European journal of pharmacology, 1994, Apr-11, Volume: 256, Issue:1

    Topics: Aging; Amino Acid Sequence; Animals; Blood Pressure; Dose-Response Relationship, Drug; Dynorphins; Heart Rate; Hemodynamics; Hippocampus; Male; Microinjections; Molecular Sequence Data; Naltrexone; Peptide Fragments; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Species Specificity

1994
Endogenous dynorphin modulates calcium-mediated antinociception in mice.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:2

    Topics: Animals; Calcium; Dynorphins; Injections, Spinal; Male; Mice; Mice, Inbred ICR; Naloxone; Naltrexone; Nociceptors; Peptide Fragments; Phenobarbital

1993
Inhibition of lipopolysaccharide-induced nitric oxide and cytokine production by ultralow concentrations of dynorphins in mixed glia cultures.
    The Journal of pharmacology and experimental therapeutics, 1997, Volume: 280, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Cells, Cultured; Dynorphins; Lipopolysaccharides; Mice; Naltrexone; Neuroglia; Nitric Oxide; Peptide Fragments; Pyrrolidines; Tumor Necrosis Factor-alpha

1997
Dynorphin-(1-8) inhibits the release of substance P-like immunoreactivity in the spinal cord of rats following a noxious mechanical stimulus.
    European journal of pharmacology, 1997, Apr-04, Volume: 323, Issue:2-3

    Topics: Animals; Decerebrate State; Dynorphins; Hindlimb; Male; Naltrexone; Pain; Peptide Fragments; Physical Stimulation; Radioimmunoassay; Rats; Rats, Wistar; Receptors, Opioid, kappa; Spinal Cord; Substance P

1997
The neuropeptide FF analogue, 1DMe, reduces in vivo dynorphin release from the rat spinal cord.
    Journal of neurochemistry, 2002, Volume: 81, Issue:3

    Topics: Animals; Dose-Response Relationship, Drug; Dynorphins; Injections, Spinal; Male; Models, Animal; Naltrexone; Narcotic Antagonists; Oligopeptides; Peptide Fragments; Perfusion; Radioimmunoassay; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Somatostatin; Spinal Cord

2002
Effect of prodynorphin-derived opioid peptides on the ovulatory luteinizing hormone surge in the proestrous rat.
    Endocrine, 2002, Volume: 18, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Brain; Dynorphins; Enkephalins; Female; Luteinizing Hormone; Naltrexone; Ovulation; Peptide Fragments; Proestrus; Protein Precursors; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2002