Compounds > dw a 2114r
Page last updated: 2024-08-25

dw a 2114r and carboplatin

dw a 2114r has been researched along with carboplatin in 47 studies

Research

Studies (47)

TimeframeStudies, this research(%)All Research%
pre-199011 (23.40)18.7374
1990's36 (76.60)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Nakai, Y1
Arai, Y; Hashimura, T; Kamoto, T; Matsuda, T; Oishi, K; Takeuchi, H; Yoshida, O1
Akamatsu, K; Endo, K; Kamisango, K; Koizumi, K; Koizumi, M; Matsumoto, T; Morikawa, K1
Christian, MC1
Inoue, S; Ito, M; Mizuno, S; Ohnuma, T1
Furuhashi, Y; Iwata, M; Kano, T; Kawai, M; Kikkawa, F; Maeda, O; Misawa, T; Morikawa, Y; Oguchi, H; Tomada, Y1
Fujimoto, S; Hashimoto, M; Kato, T; Nishimura, H; Nishiya, I; Sasaki, H; Terashima, Y; Yajima, A; Yakushiji, M; Yamabe, T1
Souma, R; Takamoto, S1
Koizumi, K; Matsumoto, T; Matsuoka, Y; Morikawa, K1
Ariyoshi, Y; Furue, H; Hasegawa, K; Majima, H; Miyake, H; Niitani, H; Ogawa, M; Sakai, Y; Taguchi, T; Wakui, A1
Akamatsu, K; Kamisango, K; Koizumi, K; Matsumoto, T; Morikawa, K; Tashiro, T1
Ariyoshi, Y; Fukuoka, M; Furusawa, M; Hasegawa, K; Kimura, I; Kumoi, T; Kurita, Y; Matsunaga, T; Niitani, H; Tamura, M1
Aoyama, H; Asaishi, K; Hayasaka, H; Izuo, M; Kubo, K; Majima, H; Ogawa, M; Uchino, J; Wada, T; Yasutomi, M1
Akamatsu, K; Endo, K; Koizumi, K; Koizumi, M; Matsumoto, T; Mitsui, H; Morikawa, K2
Akamatsu, K; Endo, K; Kaiho, S; Koizumi, K; Koizumi, M; Matsumoto, T; Mitsui, H; Morikawa, K; Tsunenari, T1
Akamatsu, K; Koizumi, K; Matsumoto, T; Mitsui, H1
Akamatsu, K; Endoh, K; Honda, M; Koizumi, M; Matsumoto, T; Mitsui, H; Morikawa, K1
Kobayashi, H; Miyachi, H; Ogawa, T; Takemura, Y1
Akamatsu, K; Endoh, K; Kamisango, K; Koizumi, K; Koizumi, M; Matsumoto, T; Matsuno, T; Mitsui, H; Morikawa, K1
Furuhashi, Y; Iwata, M; Izuta, S; Kojima, K; Suzuki, M; Tomoda, Y; Yoshida, S1
Abe, O; Furukawa, T; Ishibiki, K; Josui, K; Kase, S; Kodaira, S; Kubota, T; Takahara, T; Takeuchi, T; Yamaguchi, H1
Araki, Y; Makino, S; Tamura, K1
Akamatsu, K; Endo, K; Kamisango, K; Koizumi, K; Koizumi, M; Matsumoto, T; Matsuno, T; Mitsui, H; Morikawa, K2
Hiraki, S; Kiura, K; Kozuka, A; Mima, Y; Moritaka, T; Ohnoshi, T; Ueoka, H; Uji, H; Yamashita, H; Yonei, T1
Honda, M; Itoh, M; Murata, H; Ochi, K; Watanabe, Y1
Suzumori, K; Yagami, Y; Yasui, Y1
Furukawa, S; Kubota, A; Miyata, K; Mochimatsu, I; Ryo, I; Sawaki, S; Tukuda, M; Yanoma, S; Yoshida, T1
Fujita, H; Okamoto, M; Takao, A1
Majima, H1
Ariyoshi, Y; Ota, K1
Akasaka, Y; Machida, T1
Nishimura, H; Yakushiji, M1
Hamaguchi, K; Kato, T; Kishi, N; Matsumura, T; Miyahara, K; Nishimura, H; Tashiro, M; Yakushiji, M1
Akaboshi, M; Kawai, K; Miyahara, T; Takada, S; Ujeno, Y1
Kudo, C; Saito, M; Yoshida, T1
Imamiya, S; Maezawa, H; Mori, T; Ohizumi, Y1
Higashide, K; Kikkawa, F; Maeda, O; Misawa, T; Obata, NH; Suganuma, N; Tomoda, Y1
Ariyoshi, Y; Ogawa, M1
Chung, YS; Kato, Y; Kubo, T; Maeda, K; Nakata, B; Nitta, A; Okuno, M; Sowa, M; Yashiro, M1
Adachi, J; Matsuoka, A; Sugiyama, O; Suzuki, H; Ueda, O1
Ota, K1
Inada, T; Kakehi, M; Kubota, N1
Fujiwara, Y; Nakamura, M; Yokoo, S1
Kojima, Y; Kotake, T; Maeda, O; Miki, T; Nonomura, N; Okuyama, A; Saiki, S; Sawada, M1
Bloemink, MJ; Heetebrij, RJ; Pérez, JM; Reedijk, J1

Reviews

4 review(s) available for dw a 2114r and carboplatin

ArticleYear
[Development of platinum analogues for the treatment of lung cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Female; Humans; Lung Neoplasms; Male; Organoplatinum Compounds

1992
The current status of new platinum analogs.
    Seminars in oncology, 1992, Volume: 19, Issue:6

    Topics: Animals; Antineoplastic Agents; Carboplatin; Chemistry, Pharmaceutical; Cyclobutanes; Drugs, Investigational; Forecasting; Humans; Neoplasms; Organoplatinum Compounds; Oxaliplatin

1992
New anticancer drugs under clinical trials in Japan.
    Hematology/oncology clinics of North America, 1994, Volume: 8, Issue:2

    Topics: Animals; Antibiotics, Antineoplastic; Antineoplastic Agents; Carboplatin; Cisplatin; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Humans; Japan; Organoplatinum Compounds

1994
[Cisplatinum compounds].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Humans; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Ovarian Neoplasms; Prostatic Neoplasms; Testicular Neoplasms

1993

Trials

6 trial(s) available for dw a 2114r and carboplatin

ArticleYear
[Development of platinum analogues for the treatment of lung cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:13

    Topics: Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Female; Humans; Lung Neoplasms; Male; Organoplatinum Compounds

1992
[Phase III study of DWA2114R for ovarian cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:9

    Topics: Adult; Aged; Anorexia; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Humans; Middle Aged; Nausea; Ovarian Neoplasms

1992
[A phase II study of DWA2114R, a new platinum complex for breast cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:7

    Topics: Anorexia; Antineoplastic Agents; Breast Neoplasms; Carboplatin; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Intravenous; Middle Aged; Nausea; Vomiting

1992
A phase I study of a new cisplatin derivative for hematologic malignancies.
    Cancer, 1990, Nov-15, Volume: 66, Issue:10

    Topics: Adult; Antineoplastic Agents; Carboplatin; Drug Administration Schedule; Female; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lymphoma, Non-Hodgkin; Male; Middle Aged; Myelodysplastic Syndromes

1990
[Current status of CDDP analogs in gynecologic malignancies].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-2

    Topics: Adolescent; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Clinical Trials as Topic; Cyclophosphamide; Double-Blind Method; Doxorubicin; Drug Evaluation; Female; Genital Neoplasms, Female; Humans; Japan; Middle Aged; Multicenter Studies as Topic; Organoplatinum Compounds; Ovarian Neoplasms; Remission Induction; Uterine Cervical Neoplasms

1989
[Cisplatinum compounds].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1993, Volume: 20, Issue:1

    Topics: Adult; Aged; Antineoplastic Agents; Carboplatin; Carcinoma, Non-Small-Cell Lung; Cisplatin; Female; Humans; Lung Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Ovarian Neoplasms; Prostatic Neoplasms; Testicular Neoplasms

1993

Other Studies

39 other study(ies) available for dw a 2114r and carboplatin

ArticleYear
[Treatment of endocrine-resistant stage D carcinoma of the prostate with a cisplatin derivative (DWA2114R): a pilot study].
    Hinyokika kiyo. Acta urologica Japonica, 1992, Volume: 38, Issue:8

    Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Agents; Carboplatin; Gonadotropin-Releasing Hormone; Humans; Male; Middle Aged; Neoplasm Staging; Orchiectomy; Pilot Projects; Prostatic Neoplasms; Remission Induction; Treatment Failure

1992
Potent antitumour activity of (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)platinum(II) monohydrate (DWA2114R) against advanced L1210 leukaemia in mice.
    British journal of cancer, 1992, Volume: 66, Issue:5

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Cycle; Cell Division; Immunity, Cellular; Leukemia L1210; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; T-Lymphocytes; Time Factors

1992
Flow cytometric analyses of the characteristics of tumor cells treated with two platinum compounds: 1,1-cyclobutanedicarboxylato(2-aminomethylpyrrolidine)- platinum(II) and cisplatin.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:11

    Topics: Antineoplastic Agents; Bromodeoxyuridine; Carboplatin; Cell Cycle; Cell Division; Cisplatin; DNA, Neoplasm; Drug Interactions; Flow Cytometry; Humans; Ki-67 Antigen; Kinetics; Lung Neoplasms; Mitochondria; Neoplasm Proteins; Nuclear Proteins; Rhodamine 123; Rhodamines; Subcellular Fractions; Time Factors; Tumor Cells, Cultured

1992
Accumulation of cis-diamminedichloroplatinum (II) and its analogues in sensitive and resistant human ovarian carcinoma cells.
    Oncology, 1992, Volume: 49, Issue:3

    Topics: Antineoplastic Agents; Carboplatin; Cisplatin; Cystadenocarcinoma; Female; Humans; Ovarian Neoplasms; Sensitivity and Specificity; Tumor Cells, Cultured

1992
[Flow cytometric analysis of the effect of DWA2114R on the cell cycle traverse of RPMI 8402 cells--comparison with CDDP].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:4

    Topics: Antineoplastic Agents; Carboplatin; Cell Cycle; Cell Division; Cisplatin; Flow Cytometry; Humans; Leukemia, T-Cell; Tumor Cells, Cultured

1992
The interactions of (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato)platinum(II) monohydrate (DWA2114R) and related compounds with deoxyribonucleic acid.
    Chemical & pharmaceutical bulletin, 1992, Volume: 40, Issue:1

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cattle; DNA

1992
[A phase I study of DWA2114R].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:5

    Topics: Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Carboplatin; Drug Evaluation; Female; Humans; Infusions, Intravenous; Leukopenia; Male; Middle Aged; Neoplasms; Vomiting

1992
Antitumor activity and cellular accumulation of a new platinum complex, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum( II) monohydrate, in cisplatin-sensitive and -resistant murine P388 leukemia cells.
    Japanese journal of cancer research : Gann, 1992, Volume: 83, Issue:3

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Drug Resistance; Drug Screening Assays, Antitumor; Leukemia P388; Structure-Activity Relationship

1992
[A phase I study on a weekly schedule of DWA2114R].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:7

    Topics: Adult; Aged; Antineoplastic Agents; Carboplatin; Drug Administration Schedule; Drug Evaluation; Female; Humans; Infusions, Intravenous; Leukopenia; Lung Neoplasms; Male; Middle Aged; Neutropenia

1992
[Effect of treatment schedule of an antitumor platinum complex, DWA2114R, on the antitumor activity].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:2

    Topics: Animals; Antineoplastic Agents; Carboplatin; Colonic Neoplasms; Drug Administration Schedule; Injections; Lung Neoplasms; Male; Mice; Tumor Cells, Cultured

1992
[Combination therapy of a new platinum complex, DWA2114R with various antitumor agents against mouse tumors in vivo].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:2

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cyclophosphamide; Doxorubicin; Etoposide; Female; Fibrosarcoma; Fluorouracil; Leukemia P388; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Ovarian Neoplasms; Sarcoma, Experimental; Vindesine

1992
[Interaction of (-)-(R)-2-aminomethylpyrrolidine (1,1-cyclobutanedicarboxylato) platinum (II) monohydrate with DNA as determined by a nitrocellulose filter binding assay].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1992, Volume: 19, Issue:2

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Collodion; DNA; Drug Interactions; Filtration

1992
Synthesis, antitumor activity, and nephrotoxicity of the optical isomers of 2-aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)platinum(II).
    Journal of pharmaceutical sciences, 1991, Volume: 80, Issue:9

    Topics: Animals; Antineoplastic Agents; Carboplatin; Colonic Neoplasms; Kidney; Male; Mice; Neoplasm Transplantation; Stereoisomerism

1991
Antitumor activities of new platinum compounds, DWA2114R, NK121 and 254-S, against human leukemia cells sensitive or resistant to cisplatin.
    Investigational new drugs, 1991, Volume: 9, Issue:4

    Topics: Antineoplastic Agents; Carboplatin; Cell Count; Cell Division; Cisplatin; Drug Resistance; Drug Screening Assays, Antitumor; Drugs, Investigational; Humans; Leukemia; Molecular Structure; Organoplatinum Compounds; Tumor Cells, Cultured

1991
Comparison of the antitumour effects and nephrotoxicity-inducing activities of two new platinum complexes, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato+ ++)-platinum (II) monohydrate, and its enantiomeric isomer.
    British journal of cancer, 1991, Volume: 64, Issue:1

    Topics: Animals; Antineoplastic Agents; Blood Urea Nitrogen; Carboplatin; Isomerism; Kidney; Leukemia L1210; Male; Mice; Mice, Inbred DBA; Mice, Inbred Strains; Tissue Distribution

1991
Sequence-dependent termination of mammalian DNA polymerase reaction by a new platinum compound, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutane-dicarboxylato)-2-plati num(II) monohydrate).
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:4

    Topics: Animals; Antineoplastic Agents; Base Sequence; Carboplatin; Cattle; DNA Polymerase I; DNA Polymerase II; DNA Replication; Molecular Sequence Data; Organoplatinum Compounds; Peptide Chain Elongation, Translational

1991
Toxicological and tumoricidal evaluations of a new platinum complex, (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato+ ++)platinum( II) monohydrate, in rats.
    Japanese journal of cancer research : Gann, 1991, Volume: 82, Issue:6

    Topics: Animals; Antineoplastic Agents; Carboplatin; Carcinoma 256, Walker; Cisplatin; Male; Rats; Rats, Inbred Strains; Structure-Activity Relationship

1991
[Antitumor activity and toxicity of KB-5424 R, a newly developed antitumor platinum compound].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1991, Volume: 18, Issue:7

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Drug Screening Assays, Antitumor; Kidney; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Neoplasms, Experimental; Optical Rotation; Organoplatinum Compounds; Rats; Rats, Inbred F344

1991
[Antitumor activity of a new platinum complex, (R)-(-)-2-aminomethylpyrrolidine (1, 1-cyclobutanedicarboxylato) platinum (II), against cisdiamminedichloroplatinum (II)-resistant murine leukemia cell line].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1990, Volume: 17, Issue:1

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Line; Cisplatin; Drug Evaluation, Preclinical; Drug Resistance; In Vitro Techniques; Leukemia L1210; Mice; Neoplasm Transplantation; Organoplatinum Compounds

1990
[Comparison of the antitumor activity of newly developed platinum analogs in lung cancer using the colony assay].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:3 Pt 1

    Topics: Antineoplastic Agents; Carboplatin; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Cell Line; Cisplatin; Humans; In Vitro Techniques; Lung Neoplasms; Organoplatinum Compounds; Tumor Cells, Cultured; Tumor Stem Cell Assay

1989
Reaction of (R)-(-)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)platinum( II) with guanosine.
    Chemical & pharmaceutical bulletin, 1989, Volume: 37, Issue:10

    Topics: Carboplatin; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Guanosine; Magnetic Resonance Spectroscopy; Organoplatinum Compounds

1989
[Comparative studies of the antitumor activities of CDDP and the analogs--using gynecological carcinomas transplanted into nude mice].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:3 Pt 1

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Female; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms; Prognosis; Transplantation, Heterologous; Uterine Neoplasms

1989
[Experimental study on combination chemotherapy with platinum compounds and 5-fluorouracil].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:3 Pt 1

    Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, Squamous Cell; Cell Survival; Cisplatin; Fluorouracil; Humans; In Vitro Techniques; Organoplatinum Compounds; Pharyngeal Neoplasms; Tumor Cells, Cultured

1989
[Pharmacokinetics of new cisplatin analogues in experimental animals].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-2

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Mice; Organoplatinum Compounds; Platinum; Protein Binding; Rabbits; Sarcoma 180; Tissue Distribution

1989
[Present status of cisplatin (CDDP) analogues in Japan].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-2

    Topics: Antineoplastic Agents; Carboplatin; Chemical Phenomena; Chemistry; Cisplatin; Female; Humans; Kidney; Leukopenia; Nervous System; Organoplatinum Compounds; Platinum; Protein Binding; Thrombocytopenia

1989
[Preclinical and clinical evaluation of toxicity and antitumor activity of cisplatin analogues].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-2

    Topics: Animals; Antineoplastic Agents; Bone Marrow; Carboplatin; Cisplatin; Drug Evaluation; Drug Screening Assays, Antitumor; Humans; Kidney; Leukopenia; Mice; Neoplasms; Neoplasms, Experimental; Organoplatinum Compounds; Thrombocytopenia

1989
[Experimental evaluation of cisplatin analogous in urogenital cancer].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:4 Pt 2-2

    Topics: Adult; Aged; Aged, 80 and over; Animals; Antineoplastic Agents; Carboplatin; Cisplatin; Drug Evaluation; Humans; Kidney; Leukopenia; Male; Mice; Mice, Inbred Strains; Middle Aged; Organoplatinum Compounds; Prostatic Neoplasms; Rats; Rats, Inbred Strains; Testicular Neoplasms; Testis; Thrombocytopenia; Urinary Bladder Neoplasms; Urogenital Neoplasms

1989
[Antitumor activity of a new platinum complex (R)-(-)-2-aminomethylpyrrolidine (1,1-cyclobutane dicarboxylato) platinum (II) (DWA2114R) by its serial administration].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1989, Volume: 16, Issue:5

    Topics: Animals; Antineoplastic Agents; Carboplatin; Drug Screening Assays, Antitumor; Drug Tolerance; Fibrosarcoma; Injections, Intraperitoneal; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Organoplatinum Compounds; Weight Loss

1989
Antitumor activity of cisplatin analogs against malignant ovarian tumor xenografts into nude mice.
    Nihon Sanka Fujinka Gakkai zasshi, 1988, Volume: 40, Issue:11

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cell Line; Cisplatin; Cystadenocarcinoma; Drug Screening Assays, Antitumor; Female; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Ovarian Neoplasms

1988
Binding characteristics of (-)-(R)-2-aminomethylpyrrolidine(1,1-cyclobutanedicarboxylato)-2-platin um(II) to DNA, RNA and protein molecules in HeLa cells and its lethal effect: comparison with cis- and trans-diamminedichloroplatinums(II).
    Japanese journal of cancer research : Gann, 1994, Volume: 85, Issue:1

    Topics: Carboplatin; Cell Division; Cell Survival; Cisplatin; DNA; HeLa Cells; Humans; Platinum; Proteins; RNA

1994
Curative treatments of murine Colon26 solid tumors by immunochemotherapy with G-CSF and OK-432.
    Immunopharmacology, 1995, Volume: 29, Issue:3

    Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Cytotoxicity, Immunologic; Epirubicin; Female; Granulocyte Colony-Stimulating Factor; Immunologic Factors; Macrophages; Mice; Mice, Inbred BALB C; Mitomycin; Neoplasm Proteins; Picibanil; Recombinant Proteins; Tumor Cells, Cultured

1995
Synergistic effects of hyperthermia and intratumorous injection of anti-cancer drugs.
    The Tokai journal of experimental and clinical medicine, 1993, Volume: 18, Issue:3-6

    Topics: Aclarubicin; Animals; Antineoplastic Agents; Carboplatin; Carcinoma, Lewis Lung; Combined Modality Therapy; Disease Models, Animal; Female; Hyperthermia, Induced; Injections, Intralesional; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Peplomycin

1993
Establishment and characterization of acquired resistance to platinum anticancer drugs in human ovarian carcinoma cells.
    Japanese journal of cancer research : Gann, 1995, Volume: 86, Issue:1

    Topics: Camptothecin; Carboplatin; Cisplatin; Cystadenocarcinoma, Serous; Drug Resistance; Drug Resistance, Multiple; Etoposide; Female; Glutathione; Glutathione Transferase; Humans; Ovarian Neoplasms; Tumor Cells, Cultured

1995
[Experimental study on the anti-tumor effect of CDDP derivatives against the gastric cancer cell lines].
    Gan to kagaku ryoho. Cancer & chemotherapy, 1994, Volume: 21, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Agents; Carboplatin; Cell Division; Cisplatin; Humans; Organoplatinum Compounds; Stomach Neoplasms; Tumor Cells, Cultured

1994
[An application of in vitro fertilization--embryo culture--embryo transfer system on the drug safety evaluation: fertility test of male mice administered with the anticancer drug].
    Jikken dobutsu. Experimental animals, 1993, Volume: 42, Issue:4

    Topics: Animals; Antineoplastic Agents; Carboplatin; Cells, Cultured; DNA; Drug Evaluation, Preclinical; Embryo Transfer; Female; Fertility; Fertilization in Vitro; Germ Cells; Male; Mice; Mice, Inbred ICR

1993
Hyperthermic enhancement of cell killing by five platinum complexes in human malignant melanoma cells grown as monolayer cultures and multicellular spheroids.
    International journal of radiation oncology, biology, physics, 1993, Feb-15, Volume: 25, Issue:3

    Topics: Antineoplastic Agents; Carboplatin; Cell Survival; Cisplatin; Hot Temperature; Humans; Melanoma; Organoplatinum Compounds; Radiation-Sensitizing Agents; Tumor Cells, Cultured

1993
A new anticancer platinum compound, (-)-(R)-2-aminomethyl-pyrrolidine(1,1-cyclobutanedicarboxylato) platinum(II): DNA interstrand crosslinking, repair and lethal effects in normal human, Fanconi's anaemia and xeroderma pigmentosum cells.
    British journal of cancer, 1993, Volume: 67, Issue:6

    Topics: Antineoplastic Agents; Carboplatin; Cells, Cultured; Cisplatin; DNA Damage; DNA Repair; Fanconi Anemia; Humans; Mutation; Xeroderma Pigmentosum

1993
Antitumor effect of CPT-11, a camptothecin derivative, on human testicular tumor xenografts in nude mice.
    European urology, 1997, Volume: 31, Issue:1

    Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carboplatin; Cisplatin; Dose-Response Relationship, Drug; Etoposide; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organoplatinum Compounds; Teratocarcinoma; Testicular Neoplasms; Topoisomerase I Inhibitors; Transplantation, Heterologous; Vinblastine

1997
The new anticancer drug [(2R)-aminomethylpyrrolidine](1, 1-cyclobutanedicarboxylato)platinum(II) and its toxic S enantiomer do interact differently with nucleic acids.
    Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 1999, Volume: 4, Issue:5

    Topics: Antineoplastic Agents; Binding, Competitive; Carboplatin; Deoxyguanine Nucleotides; Deuterium Oxide; DNA; DNA Adducts; Guanosine Monophosphate; Kinetics; Models, Molecular; Nucleic Acid Conformation; Stereoisomerism; Temperature

1999