dup 734 has been researched along with piperidines in 20 studies
| Studies (dup 734) | Trials (dup 734) | Recent Studies (post-2010) (dup 734) | Studies (piperidines) | Trials (piperidines) | Recent Studies (post-2010) (piperidines) |
|---|---|---|---|---|---|
| 25 | 0 | 0 | 40,235 | 5,221 | 14,545 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 19 (95.00) | 18.2507 |
| 2000's | 1 (5.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, L; Rohrbach, KW; Tam, SW | 1 |
| Cook, L; Gilligan, PJ; Schmidt, WK; Steinfels, GF; Tam, SW | 1 |
| Culp, SG; De Souza, EB; Rominger, D; Tam, SW | 1 |
| De Souza, EB; Heroux, JA; Tam, SW | 1 |
| Kapil, RP; Lam, GN | 2 |
| Deben, SE; Gonzalez-Alvear, GM; Thompson-Montgomery, D; Werling, LL | 1 |
| Araki, H; Ogawa, S; Okuyama, S; Otomo, S; Tsuchida, K | 1 |
| Araki, H; Ogawa, S; Okuyama, S; Otomo, S | 1 |
| Kapil, RP; Lam, GN; Lee, W; Saxton, PL; Wong, NY | 1 |
| Dannals, RF; Mathews, WB; Musachio, JL; Ravert, HT; Scheffel, U; Stathis, M | 1 |
| De Souza, EB; Hurt, SD; Rominger, D; Tam, SW; Watanabe, M | 1 |
| Jin, J; Watanabe, S; Yamamoto, T | 1 |
| Ault, DT; Werling, LL | 1 |
| Gonzalez, GM; Werling, LL | 1 |
| Ault, DT; Radeff, JM; Werling, LL | 1 |
| Krylatov, AV; Lishmanov, IuB; Maslov, LN; Naryzhnaia, NV | 1 |
| Maslov, LN; Naryzhnaya, NV; Tam, SW | 1 |
| Bogomaz, SA; Gilligan, P; Lishmanov, IuB; Maslov, LN; Tam, SW | 1 |
| Nuwayhid, SJ; Werling, LL | 1 |
20 other study(ies) available for dup 734 and piperidines
| Article | Year |
|---|---|
DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'- oxoethyl)piperidine HBr], a potential antipsychotic agent: preclinical behavioral effects.
Topics: Aggression; Animals; Antipsychotic Agents; Apomorphine; Avoidance Learning; Behavior, Animal; Chlorpromazine; Haloperidol; Male; Mescaline; Mice; Mice, Inbred BALB C; Piperidines; Rats; Receptors, Serotonin; Receptors, sigma | 1992 |
DuP 734 [1-(cyclopropylmethyl)-4-(2'(4''-fluorophenyl)-2'-oxoethyl)- piperidine HBr], a sigma and 5-hydroxytryptamine2 receptor antagonist: receptor-binding, electrophysiological and neuropharmacological profiles.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Biogenic Amines; Guinea Pigs; Male; Phenazocine; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Dopamine; Receptors, Serotonin; Receptors, sigma; Rotation; Serotonin Antagonists | 1992 |
[3H]DuP 734 [1-(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'- oxoethyl)-piperidine HBr]: a receptor binding profile of a high-affinity novel sigma receptor ligand in guinea pig brain.
Topics: Animals; Antipsychotic Agents; Brain; Guanylyl Imidodiphosphate; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Mice; Phenazocine; Phenytoin; Piperidines; Receptors, sigma; Structure-Activity Relationship; Temperature | 1992 |
Autoradiographic identification and characterization of sigma receptors in guinea pig brain using [3H]1(cyclopropylmethyl)-4-(2'-(4''-fluorophenyl)-2'-oxoethyl) piperidine ([3H]DuP 734), a novel sigma receptor ligand.
Topics: Animals; Autoradiography; Brain Chemistry; Guinea Pigs; In Vitro Techniques; Male; Piperidines; Radioligand Assay; Receptors, sigma; Tritium | 1992 |
Pharmacokinetics and presystemic hepatic first-pass elimination of a novel sigma receptor antagonist, DuP 734, in the rat.
Topics: Administration, Oral; Animals; Antipsychotic Agents; Biological Availability; Chromatography, High Pressure Liquid; Infusions, Intravenous; Intestinal Absorption; Liver; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin Antagonists; Tissue Distribution | 1995 |
Functional and binding properties of sigma receptors in rat cerebellum.
Topics: Animals; Binding, Competitive; Cerebellum; Cyclohexylamines; Female; Glycine; Haloperidol; Male; N-Methylaspartate; Norepinephrine; Pentazocine; Piperidines; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Stereoisomerism | 1995 |
Dose and species dependent pharmacokinetics of a novel sigma receptor antagonist, DuP 734.
Topics: Animals; Biological Availability; Dogs; Dose-Response Relationship, Drug; Female; Half-Life; Injections, Intravenous; Intestinal Absorption; Macaca fascicularis; Male; Mice; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Serotonin Antagonists; Species Specificity; Tissue Distribution | 1995 |
The sigma-selective ligand NE-100 attenuates the effect of phencyclidine in a rat diving model.
Topics: Animals; Anisoles; Carbazoles; Diving; Male; Motor Activity; Phencyclidine; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma | 1995 |
Effect of NE-100, a novel sigma receptor ligand, on phencyclidine-induced cognitive dysfunction.
Topics: Animals; Anisoles; Anti-Anxiety Agents; Cognition Disorders; Drug Interactions; Ligands; Male; Phencyclidine; Physical Exertion; Piperidines; Propylamines; Pyrimidines; Rats; Rats, Wistar; Receptors, sigma; Ritanserin; Swimming | 1994 |
Determination of a novel sigma receptor antagonist, DuP 734, in rat plasma by reversed-phase high-performance liquid chromatography with ultraviolet detection.
Topics: Animals; Antipsychotic Agents; Chromatography, High Pressure Liquid; Male; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet | 1994 |
(+)-[C-11]-cis-N-benzyl-normetazocine: a selective ligand for sigma receptors in vivo.
Topics: Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cyclazocine; Haloperidol; Kinetics; Ligands; Male; Mice; Organ Specificity; Pentazocine; Phencyclidine; Piperidines; Receptors, sigma; Spiperone; Stereoisomerism; Tissue Distribution; Tomography, Emission-Computed | 1994 |
[3H]1-(cyclopropylmethyl)-4-(2-(4-fluorophenyl)-2-oxoethyl) piperidine HBr (DuP 734). A selective ligand for sigma receptors in mouse brain in vivo.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Dose-Response Relationship, Drug; Male; Mice; Mice, Inbred Strains; Phenazocine; Piperidines; Protein Binding; Receptors, sigma; Serotonin Antagonists; Tritium | 1993 |
The involvement of sigma receptors in the choice reaction performance deficits induced by phencyclidine.
Topics: Animals; Anisoles; Antipsychotic Agents; Excitatory Amino Acid Agonists; Ligands; Male; Phenazocine; Phencyclidine; Piperidines; Propylamines; Psychomotor Performance; Rats; Rats, Wistar; Reaction Time; Receptors, sigma | 1997 |
Differential modulation of NMDA-stimulated [3H]dopamine release from rat striatum by neuropeptide Y and sigma receptor ligands.
Topics: Analgesics; Animals; Corpus Striatum; Cyclohexylamines; Dopamine; Dose-Response Relationship, Drug; Ethylamines; Haloperidol; Male; N-Methylaspartate; Neuropeptide Y; Piperidines; Pyrrolidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, sigma | 1997 |
Release of [3H]dopamine from guinea pig striatal slices is modulated by sigma1 receptor agonists.
Topics: Animals; Corpus Striatum; Cyclohexylamines; Dizocilpine Maleate; Dopamine; Ethylamines; Guinea Pigs; In Vitro Techniques; Male; N-Methylaspartate; Naloxone; Pentazocine; Piperidines; Pyrrolidines; Receptors, sigma; Serotonin Antagonists; Serotonin Receptor Agonists; Sigma-1 Receptor | 1997 |
Modulation of [3H]Dopamine release from rat nucleus accumbens by neuropeptide Y may involve a sigma1-like receptor.
Topics: Animals; Antipsychotic Agents; Dopamine; In Vitro Techniques; Male; N-Methylaspartate; Neuropeptide Y; Nucleus Accumbens; Pentazocine; Peptide Fragments; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, sigma; Structure-Activity Relationship | 1998 |
[The use of opiate receptor ligands for correction of heart electrical instability].
Topics: Animals; Atrial Fibrillation; Heart; Immobilization; Ligands; Male; Myocardial Infarction; Oligopeptides; Piperidines; Pyrrolidines; Rats; Rats, Wistar; Receptors, Opioid; Receptors, Opioid, kappa; Receptors, Opioid, mu; Receptors, sigma; Stress, Physiological | 1998 |
Ligands for opioid and sigma-receptors improve cardiac electrical stability in rat models of post-infarction cardiosclerosis and stress.
Topics: Animals; Anti-Arrhythmia Agents; beta-Endorphin; Disease Models, Animal; Dynorphins; Enkephalin, Leucine-2-Alanine; Heart; Immobilization; Ligands; Morphine; Myocardial Infarction; Myocardium; Naloxone; Naltrexone; Narcotic Antagonists; Oligopeptides; Piperidines; Pyrrolidines; Rats; Receptors, Opioid; Receptors, Opioid, delta; Stress, Physiological; Ventricular Fibrillation | 1999 |
[Dependence of the pump function of the isolated rat heart on the functional activity of sigma receptors during reperfusion].
Topics: Animals; Blood Pressure; Creatine Kinase; Electrocardiography; Heart; Heart Rate; Myocardial Contraction; Myocardial Reperfusion Injury; Myocardium; Phenazocine; Piperidines; Rats; Rats, Wistar; Receptors, sigma; Ventricular Function, Left; Ventricular Pressure | 1999 |
Sigma2 (sigma2) receptors as a target for cocaine action in the rat striatum.
Topics: Animals; Benzylamines; Calcium; Cocaine; Corpus Striatum; Dopamine; Dopamine Plasma Membrane Transport Proteins; Dopamine Uptake Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indoles; Male; Maleimides; Mesylates; N-Methylaspartate; Nomifensine; Pentazocine; Piperidines; Protein Kinase C; Pyrroles; Rats; Rats, Sprague-Dawley; Receptors, sigma; Sigma-1 Receptor; Spiro Compounds; Sulfonamides; Tritium | 2006 |