dup 697 has been researched along with thiophenes in 43 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (39.53) | 18.2507 |
| 2000's | 16 (37.21) | 29.6817 |
| 2010's | 10 (23.26) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Ackerman, NR; Galbraith, W; Gans, KR; Haber, SB; Hewes, WE; Kerr, JS; Roman, RJ; Schmidt, WK; Smith, C | 1 |
| Birch, PJ; Grossman, CJ; Lucas, FS; Trevethick, MA; Wiseman, J | 1 |
| Creely, DP; Gierse, JK; Hauser, SD; Isakson, PC; Koboldt, C; Rangwala, SH; Seibert, K | 1 |
| Joshi, AS; King, SY; Raghavan, N; Shingu, H; Takahashi, K; Williams, RM | 1 |
| Copeland, RA; Covington, M; Giannaras, J; Nurnberg, S; Pick, S; Pinto, D; Trzaskos, JM; Williams, JM | 1 |
| Masferrer, JL; Needleman, P; Salvemini, D; Seibert, K | 1 |
| Hiraoka, I; Kataoka, K; Kinouchi, T; Ohnishi, Y; Uejima, M | 1 |
| Bjarnason, I; Mahmud, T; Rafi, SS; Scott, DL; Wrigglesworth, JM | 1 |
| Folco, GC | 1 |
| Bayly, C; Mancini, JA; Riendeau, D; Waterman, HL; Wong, E | 1 |
| de Belleroche, J; Hay, C | 1 |
| Konishi, N; Matsuo, M; Nakamura, K; Ochi, T; Senoh, H; Tojo, T; Tsuji, K | 1 |
| Akimoto, S; Bing, SR; Hiraoka, I; Kataoka, K; Kinouchi, T; Kuwahara, T; Nakayama, H; Ohnishi, Y; Shimono, K; Uejima, M | 1 |
| Forghani, F; Keen, S; Ouellet, M; Percival, MD; Tagari, P | 1 |
| Chapman, K; McKnight, W; Wallace, JL | 1 |
| Batt, DG; Copeland, RA; Covington, MB; Houghton, GC; Jetter, JW; Magolda, RL; Orwat, MJ; Petraitis, JJ; Pinto, DJ; Pitts, WJ; Sherk, SR; Trzaskos, JM; Wang, S | 1 |
| Danon, A; Rimon, G; Rosenstock, M | 1 |
| McKnight, W; Reuter, BK; Vergnolle, N; Wallace, JL | 1 |
| Barnett, K; Bell, CJ; Dicay, M; McKnight, W; Sharkey, KA; Wallace, JL | 1 |
| Danon, A; Rimon, G; Rosenstock, M; Rubin, M | 1 |
| Chen, C; Hsu, A; Johnson, AJ; song, X | 1 |
| Comp, PC; Funahashi, T; Igarashi, H; Kincade, PW; Matsuzawa, Y; Medina, KL; Meka, CS; Miyagawa, J; Nishida, M; Oritani, K; Takahashi, M; Tomiyama, Y; Yokota, T | 1 |
| Izon, DJ; Loftin, C; Spain, LM; Xu, H | 1 |
| Buursma, AR; de Vries, EF; Vaalburg, W; van Waarde, A | 1 |
| Arimochi, H; Hagiwara, M; Kataoka, K; Kuwahara, T; Ohnishi, Y | 1 |
| Bader, M; Cahová, M; Cervenka, L; Ganten, D; Husková, Z; Komers, R; Kramer, HJ; Skaroupková, P; Vanecková, I | 1 |
| Einspanier, R; Gabler, C; Holder, C; Odau, S | 1 |
| Golab, M; Skwarlo-Sonta, K | 1 |
| Baydoun, AR; Churchman, A; Hoffman, R | 1 |
| Gong, FJ; Li, RJ; Liu, JH; Peng, HL; Zhang, GS | 1 |
| Arnold, B; Kolaczkowska, E; Opdenakker, G; Piccard, H; Plytycz, B | 1 |
| Flood, P; Hong, JS; Hu, X; Langenbach, R; Lee, C; Qian, L; Wilson, B; Zhang, D | 1 |
| Bäck, M; Brink, C; Foudi, N; Louedec, L; Michel, JB; Norel, X; Rienzo, M | 1 |
| Colucci, M; Di Giannuario, A; Maione, F; Mascolo, N; Mastriota, M; Palmery, M; Perretti, M; Pieretti, S; Severini, C | 1 |
| Chen, ZY; Huang, Y; Lau, CW; Lee, HK; Liang, YT; Liu, J; Tsang, SY; Wong, SL; Yang, C | 1 |
| Agarwal, V; Cawkwell, L; Eagle, GL; Hodgkinson, VC; Lind, MJ; Scaife, L | 1 |
| Cao, H; Chen, X; Guan, S; He, B; Li, Y; Shi, C; Wang, J; Xu, X; Zhang, S | 1 |
| Battani, KA; Lindgren, CA; Morford, JJ; Newman, ZL; Ryan, SB; Su, Z | 1 |
| Cui, JH; Ju, J; Yoon, MH | 1 |
| Altun, A; Kaya, TT; Turgut, NH | 1 |
| Balaji, TM; Lavu, V; Prakash, PS; Rao, SR | 1 |
| Altun, A; Ataseven, H; Kaya, TT; Koyluoglu, G; Turgut, NH | 1 |
| Boubaya, L; Daci, A; Deschildre, C; Gomez, I; Jakobsson, PJ; Longrois, D; Norel, X; Ozen, G; Teskin, O; Topal, G; Uydeş-Doğan, BS | 1 |
1 review(s) available for dup 697 and thiophenes
| Article | Year |
|---|---|
New NSAIDs and gastroduodenal damage.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Humans; Isoenzymes; Membrane Proteins; Nitrobenzenes; Peptic Ulcer; Peroxidases; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Sulfonamides; Thiophenes | 1996 |
42 other study(ies) available for dup 697 and thiophenes
| Article | Year |
|---|---|
Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor.
Topics: Administration, Oral; Angiotensin II; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cattle; Digestive System; Prostaglandins; Rats; Rats, Inbred Strains; Renal Circulation; Thiophenes | 1990 |
Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Blood Platelets; Cyclooxygenase Inhibitors; Enzyme Induction; Humans; Ketoprofen; Leukocytes, Mononuclear; Structure-Activity Relationship; Thiophenes | 1995 |
Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.
Topics: Animals; Arachidonic Acid; Baculoviridae; Cloning, Molecular; Cyclooxygenase Inhibitors; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme Activation; Gene Expression Regulation, Enzymologic; Humans; Indomethacin; Nitrobenzenes; Oxygen Consumption; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Spodoptera; Sulfonamides; Thiophenes; Time Factors | 1995 |
Simultaneous quantification of an anti-inflammatory compound (DuP 697) and a potential metabolite (X6882) in human plasma and urine by high-performance liquid chromatography.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Chromatography, High Pressure Liquid; Freezing; Humans; Spectrometry, Fluorescence; Temperature; Thiophenes | 1994 |
Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Binding Sites; Cyclooxygenase Inhibitors; Enzyme Induction; Humans; In Vitro Techniques; Isoenzymes; Kinetics; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Sheep; Sulfonamides; Thiophenes | 1994 |
Pharmacological manipulation of cyclo-oxygenase-2 in the inflamed hydronephrotic kidney.
Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Cycloheximide; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dexamethasone; Dinoprostone; Hydronephrosis; Isoenzymes; Kidney; Male; Prostaglandin-Endoperoxide Synthases; Protein Synthesis Inhibitors; Rabbits; Recombinant Proteins; Thiophenes | 1996 |
Role of intestinal bacteria in ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug.
Topics: Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bacteria; Germ-Free Life; Ileal Diseases; Intestines; Rats; Rats, Wistar; Specific Pathogen-Free Organisms; Thiophenes; Ulcer | 1996 |
Nonsteroidal antiinflammatory drugs and uncoupling of mitochondrial oxidative phosphorylation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inhibitors; Flurbiprofen; Mitochondria, Liver; Oxidative Phosphorylation; Oxygen Consumption; Pyrazoles; Rats; Rats, Sprague-Dawley; Thiophenes | 1996 |
Conversion of prostaglandin G/H synthase-1 into an enzyme sensitive to PGHS-2-selective inhibitors by a double His513 --> Arg and Ile523 --> val mutation.
Topics: Amino Acid Sequence; Arginine; Binding Sites; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Histidine; Humans; Isoenzymes; Isoleucine; Membrane Proteins; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Sulfonamides; Thiophenes; Valine | 1997 |
Carrageenan-induced hyperalgesia is associated with increased cyclo-oxygenase-2 expression in spinal cord.
Topics: Animals; Carrageenan; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Hyperalgesia; Isoenzymes; Lumbosacral Region; Male; Prostaglandin-Endoperoxide Synthases; Rats; Spinal Cord; Stress, Mechanical; Thiophenes | 1997 |
Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives.
Topics: Anilides; Animals; Anti-Inflammatory Agents, Non-Steroidal; CHO Cells; Cricetinae; Cyclooxygenase Inhibitors; Indomethacin; Male; Models, Chemical; Models, Molecular; Pyrazoles; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Thiophenes | 1997 |
Culture supernatants of Lactobacillus acidophilus and Bifidobacterium adolescentis repress ileal ulcer formation in rats treated with a nonsteroidal antiinflammatory drug by suppressing unbalanced growth of aerobic bacteria and lipid peroxidation.
Topics: Administration, Oral; Animals; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bifidobacterium; Disease Models, Animal; Drug Therapy, Combination; Gram-Negative Bacteria; Gram-Positive Rods; Ileal Diseases; Injections, Subcutaneous; Lactobacillus acidophilus; Lipid Peroxidation; Rats; Rats, Wistar; Thiobarbituric Acid Reactive Substances; Thiophenes; Ulcer | 1998 |
Analysis of prostaglandin G/H synthase-2 inhibition using peroxidase-induced luminol luminescence.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Binding, Competitive; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Humans; Ibuprofen; Indicators and Reagents; Inhibitory Concentration 50; Isoenzymes; Kinetics; Luminol; Membrane Proteins; Peroxidases; Prostaglandin-Endoperoxide Synthases; Recombinant Proteins; Sensitivity and Specificity; Thiophenes; Time Factors | 1998 |
Limited anti-inflammatory efficacy of cyclo-oxygenase-2 inhibition in carrageenan-airpouch inflammation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carrageenan; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Disease Models, Animal; Drug Interactions; Indomethacin; Inflammation; Isoenzymes; Leukocytes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Thiophenes | 1999 |
Terphenyl cyclooxygenase-2 (COX-2) inhibitors: optimization of the central ring and o-biphenyl analogs.
Topics: Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Isoenzymes; Molecular Structure; Prostaglandin-Endoperoxide Synthases; Structure-Activity Relationship; Thiophenes | 1999 |
PGHS-2 inhibitors, NS-398 and DuP-697, attenuate the inhibition of PGHS-1 by aspirin and indomethacin without altering its activity.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Aspirin; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Fibroblasts; Humans; Indomethacin; Isoenzymes; Male; Membrane Proteins; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sheep; Sulfonamides; Thiophenes | 1999 |
NSAID-induced gastric damage in rats: requirement for inhibition of both cyclooxygenase 1 and 2.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Celecoxib; Cell Adhesion; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Gastric Mucosa; Isoenzymes; Ketorolac; Leukocytes; Male; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Prostaglandins; Pyrazoles; Rats; Rats, Wistar; Regional Blood Flow; Stomach; Sulfonamides; Thiophenes | 2000 |
Role of cyclooxygenase-2 in modulating gastric acid secretion in the normal and inflamed rat stomach.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Gastritis; Indomethacin; Iodoacetamide; Isoenzymes; Male; Pentagastrin; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Wistar; Thiophenes | 2000 |
Prostaglandin H synthase-2 inhibitors interfere with prostaglandin H synthase-1 inhibition by nonsteroidal anti-inflammatory drugs.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Aspirin; Cattle; Cyclooxygenase 1; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Ibuprofen; Indomethacin; Isoenzymes; Male; Microsomes; Nitrobenzenes; Prostaglandin-Endoperoxide Synthases; Seminal Vesicles; Sulfonamides; Thiophenes | 2001 |
Apoptosis signaling pathways mediated by cyclooxygenase-2 inhibitors in prostate cancer cells.
Topics: Apoptosis; Calcium; Celecoxib; Cell Cycle; Cell Survival; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; DNA Fragmentation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Flow Cytometry; Humans; Isoenzymes; Lactones; Male; Membrane Proteins; Models, Chemical; Nitrobenzenes; Phosphatidylinositol 3-Kinases; Prostaglandin-Endoperoxide Synthases; Prostatic Neoplasms; Proto-Oncogene Proteins c-bcl-2; Pyrazoles; Signal Transduction; Sulfonamides; Sulfones; Thiophenes; Time Factors; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 2001 |
Paracrine regulation of fat cell formation in bone marrow cultures via adiponectin and prostaglandins.
Topics: 3T3 Cells; Adipocytes; Adiponectin; Adipose Tissue, Brown; Animals; Bone Marrow Cells; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Humans; Intercellular Signaling Peptides and Proteins; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred BALB C; Paracrine Communication; Prostaglandin-Endoperoxide Synthases; Proteins; Recombinant Proteins; Thiophenes | 2002 |
The COX-2 inhibitor NS-398 causes T-cell developmental disruptions independent of COX-2 enzyme inhibition.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Immunologic Deficiency Syndromes; Indomethacin; Isoenzymes; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Knockout; Nitrobenzenes; Organ Culture Techniques; Prostaglandin-Endoperoxide Synthases; Receptors, Prostaglandin E; Receptors, Prostaglandin E, EP1 Subtype; Receptors, Prostaglandin E, EP2 Subtype; Sulfonamides; T-Lymphocytes; Thiophenes; Thymus Gland | 2001 |
Synthesis and in vivo evaluation of 18F-desbromo-DuP-697 as a PET tracer for cyclooxygenase-2 expression.
Topics: Animals; Brain; Cyclooxygenase 2; Fluorine Radioisotopes; Hyperalgesia; Isoenzymes; Isotope Labeling; Male; Organ Specificity; Prostaglandin-Endoperoxide Synthases; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Sprague-Dawley; Thiophenes; Tissue Distribution | 2003 |
Role of unbalanced growth of gram-negative bacteria in ileal ulcer formation in rats treated with a nonsteroidal anti-inflammatory drug.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Escherichia coli; Gram-Negative Bacteria; Ileal Diseases; Lactobacillus acidophilus; Lipopolysaccharides; Male; Peroxidase; Rats; Rats, Wistar; Thiophenes; Ulcer | 2004 |
Acute effects of cyclooxygenase-2 inhibition on renal function in heterozygous ren-2-transgenic rats on normal or low sodium intake.
Topics: Animals; Animals, Genetically Modified; Blood Pressure; Cyclooxygenase Inhibitors; Diet, Sodium-Restricted; Dinoprostone; Glomerular Filtration Rate; Kidney Cortex; Male; Nitrobenzenes; Rats; Renal Circulation; Renin; Renin-Angiotensin System; Sodium, Dietary; Sulfonamides; Thiophenes | 2004 |
Differential expression of cyclooxygenase 1 and cyclooxygenase 2 in the bovine oviduct.
Topics: Animals; Blotting, Western; Cattle; Cells, Cultured; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Estrous Cycle; Female; Gene Expression; Immunohistochemistry; Isoenzymes; Oviducts; Ovulation; Phospholipases A; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thiophenes | 2006 |
Mechanisms involved in the anti-inflammatory action of inhaled tea tree oil in mice.
Topics: Administration, Inhalation; Animals; Anti-Inflammatory Agents; Cell Count; Cyclooxygenase Inhibitors; Hypothalamo-Hypophyseal System; Immunologic Factors; Leukocytes; Male; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Models, Biological; Peritoneal Cavity; Pituitary-Adrenal System; Prostaglandin-Endoperoxide Synthases; Pyrimidines; Pyrroles; Reactive Oxygen Species; Receptors, Corticotropin-Releasing Hormone; Tea Tree Oil; Tetradecanoylphorbol Acetate; Thiophenes; Zymosan | 2007 |
Inhibition of angiogenic tubule formation and induction of apoptosis in human endothelial cells by the selective cyclooxygenase-2 inhibitor 5-bromo-2-(4-fluorophenyl)-3-(methylsulfonyl) thiophene (DuP-697).
Topics: Apoptosis; Blotting, Western; Caspase 3; Caspase 8; Caspase Inhibitors; Cells, Cultured; Chromatin Assembly and Disassembly; Collagen; Culture Media, Serum-Free; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprost; Dinoprostone; DNA Fragmentation; Dose-Response Relationship, Drug; Drug Combinations; Endothelial Cells; Flow Cytometry; Humans; Indomethacin; Laminin; Neovascularization, Physiologic; Oligopeptides; Proteoglycans; Thiophenes; Vascular Endothelial Growth Factor A | 2007 |
Dup-697, a specific COX-2 inhibitor, suppresses growth and induces apoptosis on K562 leukemia cells by cell-cycle arrest and caspase-8 activation.
Topics: Apoptosis; Bone Marrow Cells; Caspase 8; Cell Cycle; Cyclooxygenase 2 Inhibitors; Dose-Response Relationship, Drug; Enzyme Activation; Humans; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Thiophenes | 2008 |
Increased cyclooxygenase activity impairs apoptosis of inflammatory neutrophils in mice lacking gelatinase B/matrix metalloproteinase-9.
Topics: Animals; Apoptosis; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Male; Matrix Metalloproteinase 9; Membrane Proteins; Mice; Mice, Knockout; Neutrophil Infiltration; Neutrophils; Peritonitis; Prostaglandin D2; Pyrazoles; Thiophenes; Zymosan | 2009 |
Prostaglandin E2 released from activated microglia enhances astrocyte proliferation in vitro.
Topics: Animals; Astrocytes; Cell Proliferation; Cells, Cultured; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme-Linked Immunosorbent Assay; Female; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Microglia; Prostaglandin Antagonists; Rats; Rats, Inbred F344; Thiophenes; Xanthones | 2009 |
Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Aorta, Abdominal; Aortic Diseases; Atherosclerosis; Cholesterol; Cyclooxygenase 1; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Disease Models, Animal; Dose-Response Relationship, Drug; Enzyme Induction; Epoprostenol; Hypercholesterolemia; Indomethacin; Male; Norepinephrine; Rabbits; Thiophenes; Vasoconstriction; Vasoconstrictor Agents | 2009 |
Guinea pig ileum motility stimulation elicited by N-formyl-Met-Leu-Phe (fMLF) involves neurotransmitters and prostanoids.
Topics: Animals; Atropine; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Ileum; Lower Gastrointestinal Tract; Male; Mice; Mice, Inbred Strains; Muscle Contraction; Muscle, Smooth; N-Formylmethionine Leucyl-Phenylalanine; Neurokinin-1 Receptor Antagonists; Neurotransmitter Agents; Oligopeptides; Piperidines; Piroxicam; Prostaglandins; Quinuclidines; Tetrodotoxin; Thiophenes; Upper Gastrointestinal Tract | 2011 |
β-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2.
Topics: Acetylcholine; Animals; Aorta; Calcimycin; Cells, Cultured; Cyclooxygenase 2; Endothelium, Vascular; Enzyme Inhibitors; Male; Models, Animal; Oxidation-Reduction; Pyrazoles; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Sitosterols; Thiophenes; Vasodilation | 2013 |
Proteomic (antibody microarray) exploration of the molecular mechanism of action of the specific COX-2 inhibitor DuP 697.
Topics: Antineoplastic Agents; Apoptosis; bcl-X Protein; BH3 Interacting Domain Death Agonist Protein; Cell Line, Tumor; Cell Proliferation; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Glutamates; Guanine; Humans; Lung Neoplasms; Mesothelioma; Pemetrexed; Protein Array Analysis; Proteomics; Thiophenes | 2013 |
Cyclooxygenase-2 regulated by the nuclear factor-κB pathway plays an important role in endometrial breakdown in a female mouse menstrual-like model.
Topics: Animals; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Decidua; Endometrium; Female; Gene Expression Regulation, Enzymologic; Humans; Immunohistochemistry; Indomethacin; Leupeptins; Menstruation; Mice; Mice, Inbred C57BL; Models, Animal; NF-kappa B; Promoter Regions, Genetic; Protein Binding; Pyrrolidines; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Thiocarbamates; Thiophenes | 2013 |
Cyclooxygenase-2, prostaglandin E2 glycerol ester and nitric oxide are involved in muscarine-induced presynaptic enhancement at the vertebrate neuromuscular junction.
Topics: Animals; Arachidonic Acids; Benzoates; Capsaicin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Dinoprostone; Endocannabinoids; Glycerides; Imidazoles; Lizards; Miniature Postsynaptic Potentials; Muscarine; Neuromuscular Junction; NG-Nitroarginine Methyl Ester; Nitric Oxide; Schwann Cells; Sulfonamides; Thiophenes; Xanthones | 2013 |
Pharmacology of cannabinoid receptor agonists and a cyclooxygenase-2 inhibitor in rat bone tumor pain.
Topics: Animals; Arachidonic Acids; Bone Neoplasms; Cannabinoid Receptor Agonists; Cannabinoids; Cell Line, Tumor; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Female; Hyperalgesia; Pain; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; RNA, Messenger; Spinal Cord; Thiophenes; Tibia | 2013 |
Anticancer effect of COX-2 inhibitor DuP-697 alone and in combination with tyrosine kinase inhibitor (E7080) on colon cancer cell lines.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chick Embryo; Chorioallantoic Membrane; Colonic Neoplasms; Cyclooxygenase 2 Inhibitors; HT29 Cells; Humans; Neovascularization, Pathologic; Phenylurea Compounds; Protein-Tyrosine Kinases; Quinolines; Thiophenes | 2014 |
Elevated levels of cyclooxygenase 1 and 2 in human cyclosporine induced gingival overgrowth.
Topics: Adolescent; Adult; Cyclooxygenase 1; Cyclooxygenase 2; Cyclosporine; Enzyme Inhibitors; Female; Gingival Overgrowth; Humans; Immunohistochemistry; Male; Middle Aged; Periodontitis; Pyrazoles; Thiophenes; Young Adult | 2014 |
Effects of a Multikinase Inhibitor Motesanib (AMG 706) Alone and Combined with the Selective DuP-697 COX-2 Inhibitor on Colorectal Cancer Cells.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chickens; Chorioallantoic Membrane; Colorectal Neoplasms; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; HT29 Cells; Humans; Indoles; Neovascularization, Pathologic; Niacinamide; Oligonucleotides; Protein Kinase Inhibitors; Thiophenes | 2016 |
Inhibition of microsomal PGE synthase-1 reduces human vascular tone by increasing PGI
Topics: Aged; Cyclooxygenase 2; Cyclooxygenase Inhibitors; Epoprostenol; Female; Humans; Inflammation; Male; Mammary Arteries; Middle Aged; Norepinephrine; Prostaglandin-E Synthases; Saphenous Vein; Thiophenes; Vasoconstrictor Agents | 2017 |