Page last updated: 2024-08-24

duloxetine hydrochloride and paroxetine

duloxetine hydrochloride has been researched along with paroxetine in 61 studies

Research

Studies (61)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	2 (3.28)	18.2507
2000's	27 (44.26)	29.6817
2010's	24 (39.34)	24.3611
2020's	8 (13.11)	2.80

Authors

Authors	Studies
Ishigooka, J; Kasahara, T; Miura, S; Murasaki, M; Nagata, E	2
Ayan-Oshodi, M; Gonzales, CR; Knadler, MP; Kuan, HY; Lim, M; Pan, A; Reddy, S; Sathirakul, K; Skinner, MH; Wise, SD; Yeo, KP	1
Angulo, J; Cuevas, B; Cuevas, P; Gupta, S; Sáenz de Tejada, I	1
Demitrack, MA; Detke, MJ; Goldstein, DJ; Lu, Y; Mallinckrodt, C; Wiltse, C	1
Hemrick-Luecke, SK; Iyengar, S; Simmons, RM; Webster, AA; Xu, JY	1
Greist, J; Mallinckrodt, CH; McNamara, RK; Raskin, J; Rayamajhi, JN	1
Bitter, I; Demitrack, MA; Detke, MJ; Mallinckrodt, CH; McNamara, RK; Wiltse, CG	1
Brannan, SK; Delgado, PL; Detke, MJ; Mallinckrodt, CH; McNamara, RK; Tran, PV; Wang, F; Watkin, JG	1
Fava, M; Mallinckrodt, CH; Martinez, JM; Prakash, A; Watkin, JG; Wohlreich, MM	1
Frazer, A; Gould, GG; Javors, MA	1
Friede, T; Kieser, M	1
Detke, MJ; Mallinckrodt, CH; Perahia, DG; Walker, DJ; Wang, F	1
Cookson, J; Desaiah, D; Gilaberte, I; Kajdasz, DK	1
Bech, P; Kajdasz, DK; Porsdal, V	1
Eastwood, BJ; Jones, CK; Need, AB; Shannon, HE	1
Ballesteros, J; Callado, LF; Gutiérrez, M	1
Colman, SA; Harrison, GA; Hong, JP; Lee, MS; Lee, P; Liu, CY; Raskin, J; Ruschel, S; Shu, L; Wang, CY; Xu, X	1
Emanuele, E; Politi, P	1
Detke, MJ; Faries, DE; Mallinckrodt, CH; Meyers, AL; Prakash, A	1
Detke, MJ; Ossanna, MJ; Pritchett, YL; Swindle, RW; Thase, ME; Xu, J	1
Detke, MJ; Fava, M; Houston, JP; Mallinckrodt, CH; Prakash, A; Swindle, R	1
Spielmans, GI	1
Andersen, HF; Kilts, CD; Schlaepfer, TE; Wade, AG	1
Guico-Pabia, CJ; Helzner, EC; Nichols, AI; Patroneva, AL; Paul, J; Preskorn, SH	1
Spadone, C	1
Chiocchetti, B; Melani, F; Muscas, GC; Rosati, E	1
Esfahani, F; Gomori, A; Grossberndt, A; Intrater, H; Klowak, M; Leong, C; Namaka, M; Turcotte, D	1
Deshpande, A; Ing, A; Rizo, C; Seeman, N	1
Kourti, PV; Samanidou, VF	1
Hida, E; Tango, T	1
Gómez-Bernal, S; Montero, I; Rodríguez-Granados, M; Rodríguez-Pazos, L; Toribio, J	1
Kovatsi, L; Livanos, A; Njau, S; Pantazidou, K; Samanidou, V	1
Dhamee, MS; Gollapudy, S; Kumar, V	1
Barbui, C; Cipriani, A; Furukawa, TA; Koesters, M; Nosè, M; Omori, IM; Purgato, M; Trespidi, C	1
Berk, M; Dodd, S; Kelin, K; Mancini, M; Schacht, A	1
Otunctemur, A; Ozbek, E; Ozcan, L; Polat, EC	1
Dueñas, H; Haro, JM; Hong, J; Moneta, MV; Montgomery, W; Novick, D; Peng, X	1
Douzenis, A; Gournellis, R; Michopoulos, I; Nikolaou, KN; Papageorgiou, C; Papazahos, C	1
Ago, Y; Hasebe, S; Hashimoto, H; Matsuda, T; Nishiyama, S; Oka, S; Takuma, K	1
Egashira, N; Kuwahara, J; Masuda, S; Ueda, M; Ushio, S; Yamada, T; Zukeyama, N	1
Buoli, M; Cahn, W; Serati, M	1
Cipriani, A; Coghill, D; Cohen, D; Cuijpers, P; Del Giovane, C; Hazell, P; Hetrick, SE; Leucht, S; Liu, L; Liu, Y; Michael, KD; Pu, J; Qin, B; Ravindran, AV; Whittington, C; Xie, P; Yang, L; Zhang, Y; Zhou, X	1
IsHak, WW; Naghdechi, L	1
Jiao, Y; Liang, Y; Lin, J; Qu, H; Sun, Y; Xu, J; Zhao, C	1
Daali, Y; Desmeules, J; Lenglet, S; Matthey, A; Storelli, F; Thomas, A	1
Beyer, JL; Johnson, KG	1
Carleton, BC; Etminan, M; Guo, MY; Kezouh, A; Kim, DD; Procyshyn, RM; Samii, A	1
Chang, CL; Kao, WT; Lung, FW	1
Daali, Y; Desmeules, J; Storelli, F	2
Cipriani, A; Furukawa, TA; Ikeda, K; Imai, H; Maruo, K; Noma, H; Shinohara, K; Tanaka, S; Yamawaki, S	1
Alag, P; Balasubramaniam, M; Gupta, A; Gupta, S; Joshi, P; Maher, S; Tampi, D; Tampi, RR; Young, J	1
Holper, L	1
Furukawa, TA; Imai, H; Noma, H	1
Badcock, PB; Bailey, AP; Cox, GR; Hetrick, SE; McKenzie, JE; Meader, N; Merry, SN; Moller, CI; Sharma, V	1
Cipelli, R; Dell'Osso, B; Di Nicola, M; Martinotti, G; Peduto, I; Pugliese, AC; Signorelli, MS; Ventriglio, A	1
Eriksson, E; Hieronymus, F; Lisinski, A; Nilsson, S	1
Bracke, F; Frieling, H; Leffler, A	1
Hatano, M; Ikuta, T; Iwata, N; Kishi, T; Matsuda, Y; Okuya, M; Sakuma, K	1
Cao, Q; Rao, Y; Yang, R; Zhao, J	1

Reviews

18 review(s) available for duloxetine hydrochloride and paroxetine

Article	Year
Dose-response relationship of duloxetine in placebo-controlled clinical trials in patients with major depressive disorder. Psychopharmacology, 2006, Volume: 188, Issue:3 Topics: Adrenergic Uptake Inhibitors; Adult; Antidepressive Agents; Depressive Disorder; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Drug Administration Schedule; Duloxetine Hydrochloride; Europe; Female; Humans; Male; Middle Aged; Paroxetine; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome; United States	2006
An independent meta-analysis using summary data for clinical response, remission, and discontinuation for any reason from the 6 pivotal phase III randomized clinical trials of duloxetine in major depressive disorder. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:2 Topics: Antidepressive Agents, Second-Generation; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Humans; Paroxetine; Randomized Controlled Trials as Topic; Remission Induction; Thiophenes; Treatment Outcome; Withholding Treatment	2007
Efficacy of duloxetine and selective serotonin reuptake inhibitors: comparisons as assessed by remission rates in patients with major depressive disorder. Journal of clinical psychopharmacology, 2007, Volume: 27, Issue:6 Topics: Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Depressive Disorder, Major; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Fluoxetine; Humans; Paroxetine; Placebos; Randomized Controlled Trials as Topic; Remission Induction; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome	2007
Duloxetine does not relieve painful physical symptoms in depression: a meta-analysis. Psychotherapy and psychosomatics, 2008, Volume: 77, Issue:1 Topics: Adult; Analgesics; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Duloxetine Hydrochloride; Humans; Pain; Pain Measurement; Paroxetine; Psychophysiologic Disorders; Randomized Controlled Trials as Topic; Somatoform Disorders; Thiophenes; Treatment Outcome	2008
Effect of desvenlafaxine on the cytochrome P450 2D6 enzyme system. Journal of psychiatric practice, 2008, Volume: 14, Issue:6 Topics: Antidepressive Agents; Antidepressive Agents, Tricyclic; Cyclohexanols; Cytochrome P-450 CYP2D6; Depressive Disorder, Major; Desipramine; Desvenlafaxine Succinate; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Health Status; Humans; Paroxetine; Thiophenes	2008
[Severe forms of depression: the efficacy of escitalopram]. L'Encephale, 2009, Volume: 35, Issue:2 Topics: Antidepressive Agents, Second-Generation; Citalopram; Clinical Trials as Topic; Cyclohexanols; Depressive Disorder, Major; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Follow-Up Studies; Humans; Paroxetine; Personality Inventory; Psychometrics; Thiophenes; Treatment Outcome; Venlafaxine Hydrochloride	2009
A treatment algorithm for neuropathic pain: an update. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 2009, Volume: 24, Issue:12 Topics: Algorithms; Analgesics; Duloxetine Hydrochloride; gamma-Aminobutyric Acid; Humans; Neuralgia; Pain Measurement; Paroxetine; Pregabalin; Randomized Controlled Trials as Topic; Thiophenes	2009
Duloxetine versus other anti-depressive agents for depression. The Cochrane database of systematic reviews, 2012, Oct-17, Volume: 10 Topics: Antidepressive Agents; Citalopram; Cyclohexanols; Depression; Desvenlafaxine Succinate; Dibenzothiazepines; Duloxetine Hydrochloride; Fluoxetine; Humans; Paroxetine; Quetiapine Fumarate; Randomized Controlled Trials as Topic; Thiophenes; Venlafaxine Hydrochloride	2012
Treatment response for acute depression is not associated with number of previous episodes: lack of evidence for a clinical staging model for major depressive disorder. Journal of affective disorders, 2013, Sep-05, Volume: 150, Issue:2 Topics: Acute Disease; Adult; Antidepressive Agents; Citalopram; Cyclohexanols; Depression; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Paroxetine; Recurrence; Thiophenes; Time Factors; Treatment Outcome; Venlafaxine Hydrochloride	2013
Alternative pharmacological strategies for adult ADHD treatment: a systematic review. Expert review of neurotherapeutics, 2016, Volume: 16, Issue:2 Topics: Adrenergic alpha-Agonists; Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Bupropion; Central Nervous System Stimulants; Desipramine; Dopamine Agents; Droxidopa; Drug Combinations; Duloxetine Hydrochloride; Guanfacine; Histamine Agents; Humans; Lisdexamfetamine Dimesylate; Lithium Compounds; Lobeline; Mecamylamine; Memantine; Modafinil; Morpholines; Nicotinic Agonists; Nicotinic Antagonists; Nomifensine; Paroxetine; Pyridines; Pyridoxine; Pyrrolidonecarboxylic Acid; Quinazolinones; Reboxetine; Venlafaxine Hydrochloride; Wakefulness-Promoting Agents	2016
Comparative efficacy and tolerability of antidepressants for major depressive disorder in children and adolescents: a network meta-analysis. Lancet (London, England), 2016, Aug-27, Volume: 388, Issue:10047 Topics: Adolescent; Amitriptyline; Antidepressive Agents; Bayes Theorem; Child; Citalopram; Clomipramine; Confounding Factors, Epidemiologic; Depressive Disorder, Major; Desipramine; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Evidence-Based Medicine; Fluoxetine; Humans; Imipramine; Mianserin; Mirtazapine; Nortriptyline; Paroxetine; Piperazines; Randomized Controlled Trials as Topic; Research Design; Sertraline; Treatment Outcome; Triazoles; Venlafaxine Hydrochloride	2016
Advances in Pharmacotherapy of Late-Life Depression. Current psychiatry reports, 2018, 04-07, Volume: 20, Issue:5 Topics: Antidepressive Agents; Aripiprazole; Depression; Depressive Disorder; Drug Resistance; Duloxetine Hydrochloride; Humans; Paroxetine; Quetiapine Fumarate; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Sertraline; Vortioxetine	2018
Exploratory analyses of effect modifiers in the antidepressant treatment of major depression: Individual-participant data meta-analysis of 2803 participants in seven placebo-controlled randomized trials. Journal of affective disorders, 2019, 05-01, Volume: 250 Topics: Adult; Antidepressive Agents, Second-Generation; Bupropion; Citalopram; Depression; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Japan; Male; Middle Aged; Mirtazapine; Paroxetine; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Treatment Outcome; Venlafaxine Hydrochloride	2019
Antidepressants for anxiety disorders in late-life: A systematic review. Annals of clinical psychiatry : official journal of the American Academy of Clinical Psychiatrists, 2019, Volume: 31, Issue:4 Topics: Aged; Antidepressive Agents; Anxiety Disorders; Citalopram; Duloxetine Hydrochloride; Humans; Late Onset Disorders; Paroxetine; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Sertraline	2019
Melancholic features (DSM-IV) predict but do not moderate response to antidepressants in major depression: an individual participant data meta-analysis of 1219 patients. European archives of psychiatry and clinical neuroscience, 2021, Volume: 271, Issue:3 Topics: Adult; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Outcome Assessment, Health Care; Paroxetine; Randomized Controlled Trials as Topic; Young Adult	2021
New generation antidepressants for depression in children and adolescents: a network meta-analysis. The Cochrane database of systematic reviews, 2021, 05-24, Volume: 5 Topics: Adolescent; Antidepressive Agents; Bias; Child; Citalopram; Depressive Disorder, Major; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Mirtazapine; Network Meta-Analysis; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Suicidal Ideation; Venlafaxine Hydrochloride; Vilazodone Hydrochloride; Vortioxetine	2021
Antidepressants for the treatment of adults with major depressive disorder in the maintenance phase: a systematic review and network meta-analysis. Molecular psychiatry, 2023, Volume: 28, Issue:1 Topics: Adult; Amitriptyline; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Female; Fluoxetine; Fluvoxamine; Humans; Mirtazapine; Network Meta-Analysis; Paroxetine; Randomized Controlled Trials as Topic; Reboxetine; Sertraline; Venlafaxine Hydrochloride; Vortioxetine	2023
Efficacy and tolerability of antidepressant drugs in treatment of depression in children and adolescents: a network meta-analysis. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences, 2022, Aug-01, Volume: 51, Issue:4 Topics: Adolescent; Amitriptyline; Antidepressive Agents; Child; Depression; Depressive Disorder, Major; Duloxetine Hydrochloride; Escitalopram; Fluoxetine; Humans; Imipramine; Network Meta-Analysis; Paroxetine; Sertraline; Venlafaxine Hydrochloride	2022

Trials

11 trial(s) available for duloxetine hydrochloride and paroxetine

Article	Year
Duloxetine in the treatment of depression: a double-blind placebo-controlled comparison with paroxetine. Journal of clinical psychopharmacology, 2004, Volume: 24, Issue:4 Topics: Adult; Analysis of Variance; Confidence Intervals; Depressive Disorder, Major; Diagnostic and Statistical Manual of Mental Disorders; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Logistic Models; Male; Middle Aged; Paroxetine; Sleep Initiation and Maintenance Disorders; Thiophenes	2004
Incidence and duration of antidepressant-induced nausea: duloxetine compared with paroxetine and fluoxetine. Clinical therapeutics, 2004, Volume: 26, Issue:9 Topics: Adolescent; Adult; Age Factors; Aged; Aged, 80 and over; Antidepressive Agents; Antidepressive Agents, Second-Generation; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Europe; Female; Fluoxetine; Humans; Male; Middle Aged; Nausea; Paroxetine; Prevalence; Severity of Illness Index; Sex Factors; Thiophenes; Time Factors; United States	2004
Duloxetine in the acute and long-term treatment of major depressive disorder: a placebo- and paroxetine-controlled trial. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 2004, Volume: 14, Issue:6 Topics: Adult; Antidepressive Agents, Second-Generation; Body Weight; Cardiovascular Diseases; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Electrocardiography; Female; Hemodynamics; Humans; Longitudinal Studies; Male; Middle Aged; Paroxetine; Psychiatric Status Rating Scales; Sexual Dysfunction, Physiological; Thiophenes	2004
Sexual functioning assessed in 4 double-blind placebo- and paroxetine-controlled trials of duloxetine for major depressive disorder. The Journal of clinical psychiatry, 2005, Volume: 66, Issue:6 Topics: Adult; Antidepressive Agents; Comorbidity; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Humans; Incidence; Male; Middle Aged; Paroxetine; Placebos; Selective Serotonin Reuptake Inhibitors; Sexual Behavior; Sexual Dysfunctions, Psychological; Thiophenes; Treatment Outcome	2005
Duloxetine in the treatment of major depressive disorder: a placebo- and paroxetine-controlled trial. European psychiatry : the journal of the Association of European Psychiatrists, 2006, Volume: 21, Issue:6 Topics: Adult; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Duloxetine Hydrochloride; Female; Humans; Male; Mass Screening; Middle Aged; Paroxetine; Placebo Effect; Prevalence; Remission Induction; Selective Serotonin Reuptake Inhibitors; Thiophenes	2006
Treatment benefits of duloxetine in major depressive disorder as assessed by number needed to treat. International clinical psychopharmacology, 2006, Volume: 21, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors; Thiophenes; Treatment Outcome	2006
Once-daily duloxetine 60 mg in the treatment of major depressive disorder: multicenter, double-blind, randomized, paroxetine-controlled, non-inferiority trial in China, Korea, Taiwan and Brazil. Psychiatry and clinical neurosciences, 2007, Volume: 61, Issue:3 Topics: Activities of Daily Living; Adult; Antidepressive Agents; Antidepressive Agents, Second-Generation; Blood Pressure; Brazil; China; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Female; Heart Rate; Humans; Korea; Male; Middle Aged; Pain; Pain Measurement; Paroxetine; Psychiatric Status Rating Scales; Taiwan; Thiophenes; Weight Gain	2007
Differential antidepressant symptom efficacy: placebo-controlled comparisons of duloxetine and SSRIs (fluoxetine, paroxetine, escitalopram). Neuropsychobiology, 2007, Volume: 56, Issue:2-3 Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Middle Aged; Paroxetine; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Thiophenes; Treatment Outcome	2007
Clinical milestones predict symptom remission over 6-month and choice of treatment of patients with major depressive disorder (MDD). Journal of psychiatric research, 2009, Volume: 43, Issue:5 Topics: Adult; Analysis of Variance; Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Female; Follow-Up Studies; Humans; Male; Middle Aged; Paroxetine; Patient Compliance; Predictive Value of Tests; Psychiatric Status Rating Scales; Remission Induction; Thiophenes; Treatment Outcome	2009
Duloxetine, dual serotonin and norepinephrine reuptake inhibitor, versus paroxetine, selective serotonin reuptake inhibitor, in the treatment for premature ejaculation. International urology and nephrology, 2015, Volume: 47, Issue:2 Topics: Adult; Duloxetine Hydrochloride; Humans; Interpersonal Relations; Male; Paroxetine; Premature Ejaculation; Selective Serotonin Reuptake Inhibitors; Severity of Illness Index; Surveys and Questionnaires; Thiophenes	2015
5-HTT mRNA level as a potential biomarker of treatment response in patients with major depression in a clinical trial. Journal of affective disorders, 2018, 10-01, Volume: 238 Topics: Adult; Alleles; Antidepressive Agents; Biomarkers; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Genotype; Humans; Male; Middle Aged; Paroxetine; Polymorphism, Genetic; RNA, Messenger; Serotonin Plasma Membrane Transport Proteins; Time Factors; Treatment Outcome	2018

Other Studies

32 other study(ies) available for duloxetine hydrochloride and paroxetine

Article	Year
Long-lasting inhibition of 5-HT uptake of platelets in subjects treated by duloxetine, a potential antidepressant. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1996, Volume: 16, Issue:1 Topics: Adult; Antidepressive Agents; Blood Platelets; Cells, Cultured; Depression, Chemical; Duloxetine Hydrochloride; Humans; Male; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes	1996
Effects of washing procedure on platelets pretreated with serotonin uptake inhibitors in vitro: low Ki values predict long-lasting inhibition of serotonin uptake in vivo. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology, 1998, Volume: 18, Issue:1 Topics: Antidepressive Agents; Binding Sites; Blood Platelets; Cells, Cultured; Clomipramine; Depression, Chemical; Duloxetine Hydrochloride; Humans; Paroxetine; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes	1998
Duloxetine is both an inhibitor and a substrate of cytochrome P4502D6 in healthy volunteers. Clinical pharmacology and therapeutics, 2003, Volume: 73, Issue:3 Topics: Adult; Antidepressive Agents, Tricyclic; Area Under Curve; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Desipramine; Drug Administration Schedule; Drug Interactions; Duloxetine Hydrochloride; Female; Humans; Male; Middle Aged; Paroxetine; Reference Values; Selective Serotonin Reuptake Inhibitors; Thiophenes	2003
Mechanisms for the inhibition of genital vascular responses by antidepressants in a female rabbit model. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 310, Issue:1 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Arginine; Blood Vessels; Citalopram; Cyclohexanols; Drug Interactions; Duloxetine Hydrochloride; Female; Nitric Oxide; Norepinephrine; Paroxetine; Phentolamine; Rabbits; Regional Blood Flow; Selective Serotonin Reuptake Inhibitors; Serotonin; Thiophenes; Vagina; Vasodilation; Venlafaxine Hydrochloride	2004
Efficacy of duloxetine, a potent and balanced serotonin-norepinephrine reuptake inhibitor in persistent pain models in rats. The Journal of pharmacology and experimental therapeutics, 2004, Volume: 311, Issue:2 Topics: Acute Disease; Amines; Amitriptyline; Animals; Conscious Sedation; Cyclohexanecarboxylic Acids; Cyclohexanols; Cyclopropanes; Disease Models, Animal; Drug Therapy, Combination; Duloxetine Hydrochloride; Fluoxetine; Formaldehyde; Gabapentin; gamma-Aminobutyric Acid; Male; Methyltyrosines; Milnacipran; Neuromuscular Junction; Norepinephrine; p-Chloroamphetamine; Pain; Paroxetine; Rats; Rats, Sprague-Dawley; Serotonin; Thiophenes; Venlafaxine Hydrochloride	2004
An open-label study of duloxetine for the treatment of major depressive disorder: comparison of switching versus initiating treatment approaches. Journal of clinical psychopharmacology, 2005, Volume: 25, Issue:6 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antidepressive Agents; Citalopram; Cyclohexanols; Depressive Disorder, Major; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Female; Fluvoxamine; Humans; Male; Middle Aged; Paroxetine; Sertraline; Thiophenes; Treatment Outcome; Venlafaxine Hydrochloride	2005
Effect of chronic administration of duloxetine on serotonin and norepinephrine transporter binding sites in rat brain. Biological psychiatry, 2007, Jan-15, Volume: 61, Issue:2 Topics: Adrenergic Uptake Inhibitors; Animals; Antidepressive Agents; Autoradiography; Brain; Chromatography, High Pressure Liquid; Desipramine; Dose-Response Relationship, Drug; Duloxetine Hydrochloride; Male; Norepinephrine Plasma Membrane Transport Proteins; Paroxetine; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta-1; Selective Serotonin Reuptake Inhibitors; Serotonin Plasma Membrane Transport Proteins; Thiophenes	2007
Planning and analysis of three-arm non-inferiority trials with binary endpoints. Statistics in medicine, 2007, Jan-30, Volume: 26, Issue:2 Topics: Controlled Clinical Trials as Topic; Data Interpretation, Statistical; Depression; Duloxetine Hydrochloride; Humans; Paroxetine; Research Design; Sample Size; Selective Serotonin Reuptake Inhibitors; Statistics as Topic; Therapeutic Equivalency; Thiophenes	2007
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition. Neuropharmacology, 2006, Volume: 51, Issue:7-8 Topics: Adrenergic Uptake Inhibitors; Analgesics, Non-Narcotic; Animals; Anti-Inflammatory Agents, Non-Steroidal; Brain Chemistry; Carrageenan; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Drug Interactions; Duloxetine Hydrochloride; Edema; Fluoxetine; Hot Temperature; Hyperalgesia; Male; Norepinephrine; Paroxetine; Pressure; Rats; Rats, Sprague-Dawley; Selective Serotonin Reuptake Inhibitors; Serotonin; Sertraline; Thiophenes; Venlafaxine Hydrochloride	2006
Successful treatment of refractory hypochondriasis with duloxetine. Progress in neuro-psychopharmacology & biological psychiatry, 2007, Jun-30, Volume: 31, Issue:5 Topics: Adrenergic Uptake Inhibitors; Antidepressive Agents; Antidepressive Agents, Second-Generation; Duloxetine Hydrochloride; Female; Humans; Hypochondriasis; Middle Aged; Paroxetine; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Thiophenes	2007
Simple options for improving signal detection in antidepressant clinical trials. Psychopharmacology bulletin, 2007, Volume: 40, Issue:2 Topics: Antidepressive Agents; Citalopram; Clinical Trials as Topic; Databases, Factual; Depressive Disorder, Major; Dose-Response Relationship, Drug; Double-Blind Method; Duloxetine Hydrochloride; Fluoxetine; Likelihood Functions; Models, Statistical; Paroxetine; Personality Inventory; Placebo Effect; Psychometrics; Reproducibility of Results; Research Design; Signal Detection, Psychological; Thiophenes; Treatment Outcome	2007
Antidepressant-associated myoclonic status in a patient with symptomatic generalized epilepsy: does risk occur with therapeutic doses? Epilepsy & behavior : E&B, 2009, Volume: 14, Issue:4 Topics: Antidepressive Agents; Depression; Duloxetine Hydrochloride; Electroencephalography; Epilepsy, Generalized; Humans; Male; Middle Aged; Paroxetine; Seizures; Thiophenes	2009
A rapid, Web-based method for obtaining patient views on effects and side-effects of antidepressants. Journal of affective disorders, 2011, Volume: 130, Issue:1-2 Topics: Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Cyclohexanols; Data Collection; Desvenlafaxine Succinate; Duloxetine Hydrochloride; Fatigue; Fluvoxamine; Humans; Internet; Lethargy; Mianserin; Mirtazapine; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline; Sleep Stages; Thiophenes; Venlafaxine Hydrochloride	2011
Rapid HPLC method for the simultaneous monitoring of duloxetine, venlaflaxine, fluoxetine and paroxetine in biofluids. Bioanalysis, 2009, Volume: 1, Issue:5 Topics: Chromatography, High Pressure Liquid; Cyclohexanols; Duloxetine Hydrochloride; Fluoxetine; Humans; Limit of Detection; Paroxetine; Reproducibility of Results; Selective Serotonin Reuptake Inhibitors; Sensitivity and Specificity; Thiophenes; Venlafaxine Hydrochloride	2009
On the three-arm non-inferiority trial including a placebo with a prespecified margin. Statistics in medicine, 2011, Feb-10, Volume: 30, Issue:3 Topics: Algorithms; Antidepressive Agents; Computer Simulation; Confidence Intervals; Depressive Disorder, Major; Double-Blind Method; Duloxetine Hydrochloride; Humans; Models, Statistical; Monte Carlo Method; Multicenter Studies as Topic; Normal Distribution; Paroxetine; Placebos; Randomized Controlled Trials as Topic; Sample Size; Thiophenes; Treatment Outcome	2011
Erythema multiforme photoinduced by paroxetine and herpes simplex virus. Photodermatology, photoimmunology & photomedicine, 2011, Volume: 27, Issue:4 Topics: Duloxetine Hydrochloride; Erythema Multiforme; Female; Herpes Simplex; Humans; Middle Aged; Paroxetine; Photosensitivity Disorders; Selective Serotonin Reuptake Inhibitors; Simplexvirus; Thiophenes	2011
A simple HPLC method for the simultaneous determination of two selective serotonin reuptake inhibitors and two serotonin-norepinephrine reuptake inhibitors in hair, nail clippings, and cerebrospinal fluid. Journal of separation science, 2012, Volume: 35, Issue:7 Topics: Adrenergic Uptake Inhibitors; Biological Transport; Cerebrospinal Fluid; Chromatography, High Pressure Liquid; Cyclohexanols; Duloxetine Hydrochloride; Fluoxetine; Hair; Humans; Nails; Norepinephrine; Paroxetine; Selective Serotonin Reuptake Inhibitors; Thiophenes; Venlafaxine Hydrochloride	2012
A case of serotonin syndrome precipitated by fentanyl and ondansetron in a patient receiving paroxetine, duloxetine, and bupropion. Journal of clinical anesthesia, 2012, Volume: 24, Issue:3 Topics: Aged; Analgesics, Opioid; Anesthesia, General; Bupropion; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Fentanyl; Humans; Mastectomy; Ondansetron; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin Syndrome; Thiophenes	2012
Real-world outcomes in patients with depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia. Asia-Pacific psychiatry : official journal of the Pacific Rim College of Psychiatrists, 2016, Volume: 8, Issue:1 Topics: Adult; Asia, Eastern; Citalopram; Depressive Disorder, Major; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Middle Aged; Pain; Paroxetine; Prospective Studies; Quality of Life; Regression Analysis; Remission Induction; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Sertraline; Severity of Illness Index; Treatment Outcome	2016
Restless legs syndrome associated with the combined use of duloxetine plus paroxetine. Journal of clinical psychopharmacology, 2015, Volume: 35, Issue:3 Topics: Antidepressive Agents; Depressive Disorder, Major; Drug Therapy, Combination; Duloxetine Hydrochloride; Female; Humans; Middle Aged; Paroxetine; Restless Legs Syndrome	2015
Pharmacological profile of encounter-induced hyperactivity in isolation-reared mice. Behavioural pharmacology, 2015, Volume: 26, Issue:7 Spec No Topics: Animals; Animals, Outbred Strains; Benzimidazoles; Bridged Bicyclo Compounds, Heterocyclic; Desipramine; Duloxetine Hydrochloride; Fluvoxamine; Hydroxycorticosteroids; Idazoxan; Indoles; Male; Mice; Motor Activity; Neuropsychological Tests; Oxazines; Paroxetine; Piperazines; Psychotropic Drugs; Pyridines; Risperidone; Ritanserin; Social Behavior; Social Isolation; Sulfonamides; Venlafaxine Hydrochloride	2015
Comparison of the Anti-tumor Effects of Selective Serotonin Reuptake Inhibitors as Well as Serotonin and Norepinephrine Reuptake Inhibitors in Human Hepatocellular Carcinoma Cells. Biological & pharmaceutical bulletin, 2015, Volume: 38, Issue:9 Topics: Antineoplastic Agents; Carcinoma, Hepatocellular; Caspase 3; Caspase 7; Cell Line, Tumor; Cell Survival; Citalopram; Cyclopropanes; Duloxetine Hydrochloride; Fluvoxamine; Hep G2 Cells; Humans; Liver Neoplasms; Milnacipran; Paroxetine; Selective Serotonin Reuptake Inhibitors; Serotonin and Noradrenaline Reuptake Inhibitors; Sertraline	2015
Are sertraline, paroxetine and duloxetine the most effective antidepressants for use in depressed adults over 60 years? Evidence-based mental health, 2016, Volume: 19, Issue:4 Topics: Adult; Antidepressive Agents; Duloxetine Hydrochloride; Humans; Paroxetine; Selective Serotonin Reuptake Inhibitors; Sertraline	2016
Comparative efficacy and acceptability of antidepressant treatment in poststroke depression: a multiple-treatments meta-analysis. BMJ open, 2017, Aug-03, Volume: 7, Issue:8 Topics: Aged; Antidepressive Agents; Antidepressive Agents, Second-Generation; Citalopram; Depression; Depressive Disorder; Doxepin; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Morpholines; Paroxetine; Patient Acceptance of Health Care; Reboxetine; Selective Serotonin Reuptake Inhibitors; Stroke; Treatment Outcome	2017
Impact of CYP2D6 Functional Allelic Variations on Phenoconversion and Drug-Drug Interactions. Clinical pharmacology and therapeutics, 2018, Volume: 104, Issue:1 Topics: Adolescent; Adult; Alleles; Analgesics, Opioid; Antitussive Agents; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Dextromethorphan; Drug Interactions; Duloxetine Hydrochloride; Female; Genotype; Heterozygote; Homozygote; Humans; Male; Paroxetine; Pharmacogenomic Variants; Phenotype; Tramadol; Young Adult	2018
Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study. Journal of clinical psychopharmacology, 2018, Volume: 38, Issue:4 Topics: Antidepressive Agents; Basal Ganglia Diseases; Bupropion; Case-Control Studies; Citalopram; Duloxetine Hydrochloride; Female; Fluoxetine; Humans; Male; Mianserin; Middle Aged; Mirtazapine; Paroxetine; Pharmacoepidemiology; Sertraline; United States; Venlafaxine Hydrochloride	2018
Genotype-sensitive reversible and time-dependent CYP2D6 inhibition in human liver microsomes. Basic & clinical pharmacology & toxicology, 2019, Volume: 124, Issue:2 Topics: Alleles; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Demethylation; Dextromethorphan; Duloxetine Hydrochloride; Genotype; Humans; Microsomes, Liver; Paroxetine	2019
Physiologically-Based Pharmacokinetic Modeling for the Prediction of CYP2D6-Mediated Gene-Drug-Drug Interactions. CPT: pharmacometrics & systems pharmacology, 2019, Volume: 8, Issue:8 Topics: Adult; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP2D6; Dextromethorphan; Drug Interactions; Duloxetine Hydrochloride; Humans; Male; Models, Biological; Paroxetine; Pharmacogenomic Variants; Young Adult	2019
Combining threshold analysis and GRADE to assess sensitivity to bias in antidepressant treatment recommendations adjusted for depression severity. Research synthesis methods, 2020, Volume: 11, Issue:2 Topics: Acetamides; Adult; Amitriptyline; Antidepressive Agents; Bayes Theorem; Citalopram; Depressive Disorder, Major; Duloxetine Hydrochloride; Humans; Network Meta-Analysis; Paroxetine; Publication Bias; Reproducibility of Results; Severity of Illness Index; Treatment Outcome; Venlafaxine Hydrochloride	2020
Adherence to, and Persistence of, Antidepressant Therapy in Patients with Major Depressive Disorder: Results from a Population-based Study in Italy. Current neuropharmacology, 2023, Volume: 21, Issue:3 Topics: Adult; Antidepressive Agents; Citalopram; Depressive Disorder, Major; Duloxetine Hydrochloride; Escitalopram; Humans; Italy; Paroxetine; Retrospective Studies; Sertraline; Venlafaxine Hydrochloride; Vortioxetine	2023
Impact of chosen cutoff on response rate differences between selective serotonin reuptake inhibitors and placebo. Translational psychiatry, 2022, 04-14, Volume: 12, Issue:1 Topics: Antidepressive Agents; Citalopram; Duloxetine Hydrochloride; Humans; Paroxetine; Selective Serotonin Reuptake Inhibitors	2022
Antidepressants Are Poor Inhibitors of Heat-Evoked Ion Currents Mediated by TRPM2. Pharmacology, 2022, Volume: 107, Issue:9-10 Topics: Adenosine Diphosphate Ribose; Amitriptyline; Animals; Antidepressive Agents; Citalopram; Duloxetine Hydrochloride; Fluoxetine; HEK293 Cells; Hot Temperature; Humans; Ketamine; Lidocaine; Mice; Paroxetine; Pregabalin; Sertraline; TRPM Cation Channels	2022