dsr-6434 and 8-hydroxyadenine

dsr-6434 has been researched along with 8-hydroxyadenine* in 1 studies

Other Studies

1 other study(ies) available for dsr-6434 and 8-hydroxyadenine

Article	Year
Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility. Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3 We report the discovery of novel series of highly potent TLR7 agonists based on 8-oxoadenines, 1 and 2 by introducing and optimizing various tertiary amines onto the N(9)-position of the adenine moiety. The introduction of the amino group resulted in not only improved water solubility but also enhanced TLR7 agonistic activity. In particular compound 20 (DSR-6434) indicated an optimal balance between the agonistic potency and high water solubility. It also demonstrated a strong antitumor effect in vivo by intravenous administration in a tumor bearing mice model. Topics: Adenine; Administration, Intravenous; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; HEK293 Cells; Humans; Mice; Molecular Structure; Solubility; Toll-Like Receptor 7; Water	2013

Article

Year

Synthesis and evaluation of 8-oxoadenine derivatives as potent Toll-like receptor 7 agonists with high water solubility.

Bioorganic & medicinal chemistry letters, 2013, Feb-01, Volume: 23, Issue:3

We report the discovery of novel series of highly potent TLR7 agonists based on 8-oxoadenines, 1 and 2 by introducing and optimizing various tertiary amines onto the N(9)-position of the adenine moiety. The introduction of the amino group resulted in not only improved water solubility but also enhanced TLR7 agonistic activity. In particular compound 20 (DSR-6434) indicated an optimal balance between the agonistic potency and high water solubility. It also demonstrated a strong antitumor effect in vivo by intravenous administration in a tumor bearing mice model.

Topics: Adenine; Administration, Intravenous; Animals; Antineoplastic Agents; Cell Line, Tumor; Disease Models, Animal; HEK293 Cells; Humans; Mice; Molecular Structure; Solubility; Toll-Like Receptor 7; Water

2013