droxidopa has been researched along with serine in 94 studies
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 87 (92.55) | 18.7374 |
1990's | 6 (6.38) | 18.2507 |
2000's | 1 (1.06) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Cha, SH; Chairoungdua, A; Endou, H; Kanai, Y; Kim, DK; Matsuo, H | 1 |
Fujiwara, H; Ikeda, Y; Inagaki, C; Tanaka, C | 1 |
Inagaki, C; Tanaka, C | 1 |
Araki, H; Cheng, JT; Ohmura, I; Tanaka, C | 1 |
Araki, H; Inagaki, C; Ohmura, I; Tanaka, C | 1 |
Falck, B; Hardebo, JE; Owman, C | 1 |
Altier, H; Moldes, M; Monti, JM | 1 |
Hamburg, MD; Kerr, A | 1 |
Suzuki, T | 1 |
Bacciarelli, C; Bonacchi, G; Boni, P; Castellucci, A | 1 |
Fujiwara, H; Inagaki, C; Tanaka, C | 1 |
Ikeda, Y; Inagaki, C; Ishikawa, M; Tanaka, C; Yamazaki, M | 1 |
Bartholini, J; Constantinidis, J; Pletscher, A; Puig, M; Tissot, R | 1 |
Aubert, C; Constantinidis, J; Gaillard, JM; Geissbuhler, F; Hovaguimian, TH; Tissot, R | 1 |
Hegedüs, B; Krassó, AF; Noack, K; Zeller, P | 1 |
Maas, JW; Olander, R; Redmond, DE | 1 |
Hirai, M; Matsuoka, Y; Nakajima, T; Sano, I | 1 |
Igakura, T; Narabayashi, H; Ogawa, T; Yokochi, F | 1 |
Hisaki, K; Ichihara, T; Matsumura, Y; Morimoto, S; Ohyama, T; Shinyama, H; Takahashi, Y | 1 |
Bhardwaj, A; Brannan, T; Yahr, MD | 1 |
Kato, M; Matsuura, M; Nankai, M; Okubo, Y; Semba, J; Takahashi, R | 1 |
Imai, H; Itoh, T; Narabayashi, H; Yokota, J | 1 |
Dzoljic, MR; Man in't Veld, AJ; Mechelse, K; Moleman, P; Tulen, JH | 1 |
Ogawa, N; Ujike, H; Yamamoto, M | 2 |
Lakke, JP; Muskiet, FA; Staal-Schreinemachers, AL; Teelken, AW; van den Berg, GA; Wolthers, BG | 1 |
Hasegawa, Y; Koike, Y; Matsuoka, Y; Takahashi, A | 1 |
Nakanishi, T; Yoshida, M | 1 |
Kuramoto, S; Noguchi, S; Yoshida, M | 1 |
Oyabe, A; Satoh, S; Suzuki-Kusaba, M; Tanno, M | 1 |
Kagamihara, Y; Nagaoka, M; Nakajima, Y; Tanaka, R | 1 |
Hanyu, N; Nakadai, A; Yanagisawa, N; Yazawa, M; Yoshioka, J | 1 |
Hashimoto, H; Kato, N; Mori, T; Nakajima, T; Noto, T | 1 |
Kato, T; Katsube, J; Katsuyama, M; Maeda, Y; Nakamura, M; Nishikawa, S | 1 |
Biaggioni, I; Robertson, D | 1 |
Boomsma, F; Man in 't Veld, AJ; Schalekamp, MA; van den Meiracker, AH | 1 |
Nagatsu, T | 1 |
Hirose, A; Ohno, Y; Sasa, M; Takaori, S | 1 |
Narabayashi, H | 1 |
Hirose, A; Karai, N; Kato, T; Katsube, J; Katsuyama, M; Nakamura, M | 1 |
Nagatsu, T; Naoi, M | 2 |
Hashimoto, H; Kamimura, H; Mori, T; Nakajima, T; Nakao, J; Noto, T | 1 |
Karai, N; Kato, T; Katsube, J; Katsuyama, M; Nakamura, M | 4 |
Imura, H; Inoue, T; Ishikawa, Y; Kato, Y; Koshiyama, H; Murakami, Y | 1 |
Kondo, T; Nagatsu, T; Narabayashi, H; Yokochi, F | 1 |
Kuno, N; Nagatsu, T; Naoi, M; Takahashi, T | 1 |
Irie, T; Katsube, J; Sato, E | 1 |
Matsuoka, Y; Muto, T; Senda, Y; Sobue, I; Takahashi, A | 1 |
Fujii, Y; Fujiwara, H; Kondo, M; Nishino, N; Shuntoh, H; Tanaka, C | 1 |
Nabatame, H; Ohno, Y; Sasa, M; Takaori, S; Yoshimura, N | 1 |
Ikeda, S; Takatsu, M; Ushiyama, M; Yanagisawa, N; Yazawa, M | 1 |
Gibson, CJ | 1 |
Fukui, K; Hashimoto, H; Mori, M; Mori, T; Nakajima, T; Noto, T | 1 |
Ujike, H; Yamamoto, M | 1 |
Iwase, S; Kachi, T; Kunimoto, M; Mano, T; Saito, M; Sobue, I | 1 |
Komiya, T; Kondo, T; Narabayashi, H | 1 |
Boomsma, F; Man in 't Veld, AJ; Schalekamp, MA; van der Hoorn, FA | 1 |
Langlais, PJ; Mair, RG; McCourt, W; McEntee, WJ; Whalen, PJ | 1 |
Azuma, T; Ichikawa, K; Kishimoto, S; Mizuno, R; Mizuta, E; Suzuki, T; Tsujino, S | 1 |
Fukuda, H; Nagano, N; Nakamura, T; Ono, H; Tanabe, M | 1 |
Liu, F; Liu, WQ; Ma, RD; Yang, QR; Zhao, JC; Zhu, DN | 1 |
Imai, H; Komiya, T; Narabayashi, H; Usui, S | 1 |
Fukuma, A; Kitazumi, T; Matsubayashi, K; Otsuka, K; Ozawa, T; Sadakane, N; Shimada, K | 1 |
Boomsma, F; Julien, C; Lenders, J; Man in 't Veld, AJ; Schalekamp, MA; van den Meiracker, AH | 1 |
Fujita, T; Inoue, S; Kawai, K; Koide, Y; Kuzuya, N; Mizusawa, H; Murayama, Y; Yamashita, K; Yoshikawa, H; Yoshizawa, K | 1 |
Kishimoto, S; Sakoda, S; Suzuki, T; Ueji, M | 1 |
Reches, A | 1 |
Higa, S; Kishimoto, S; Matsumoto, M; Sakoda, S; Suzuki, T; Ueji, M; Yoneda, S | 1 |
Hayashi, A | 1 |
Semba, J; Takahashi, R | 1 |
Fahn, S; Jackson-Lewis, V; Reches, A | 1 |
Ogawa, N; Takayama, H; Yamamoto, M | 1 |
Araki, H; Fujiwara, H; Nakamura, M; Ohmura, I; Tanaka, C | 1 |
Araki, H; Fujiwara, H; Tanaka, C | 1 |
Edwards, DJ; Sedlock, ML | 1 |
Feldman, JM; Klatt, C; Seigler, HF; Vervaert, C | 1 |
Hayashi, A; Higa, S; Nakajima, A; Sakoda, S; Suzuki, T; Takaba, Y; Yamamura, Y | 1 |
Howes, LG; Louis, WJ; Rowe, PR; Summers, RJ | 1 |
Birkmayer, G; Birkmayer, W; Lechner, H; Riederer, P | 1 |
Hayashi, A; Kondo, T; Nagatsu, T; Narabayashi, H; Suzuki, T | 1 |
Gamaniel, K; Osuide, G; Wambebe, C | 1 |
Kuroda, H; Nukina, I; Ogawa, N; Ota, Z; Yamamoto, M | 1 |
Kondo, T | 1 |
Cilmi, KM; Hoeldtke, RD; Mattis-Graves, K | 1 |
Hayashi, A; Kishimoto, S; Kondo, T; Narabayashi, H; Sakoda, S; Suzuki, T; Ueji, M | 1 |
Hayashi, A; Higa, S; Nakajima, A; Sakoda, S; Suzuki, T; Takaba, Y; Tsuge, I; Yamamura, Y | 1 |
Edwards, DJ; Rizk, M | 1 |
Hayashi, A; Higa, S; Nakajima, A; Sakoda, S; Suzuki, T; Takaba, Y; Ueji, M | 1 |
DENGLER, H; REICHEL, G | 1 |
DALGLIESH, CE; MANN, FG | 1 |
4 review(s) available for droxidopa and serine
Article | Year |
---|---|
[Management of autonomic disorders in amyloidosis].
Topics: Amyloidosis; Catecholamines; Droxidopa; Hereditary Sensory and Autonomic Neuropathies; Humans; Hypotension; Hypotension, Orthostatic; Norepinephrine; Serine | 1979 |
[Pathogenic substances in Parkinson disease and new therapeutics considering the etiologic mechanism].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Animals; Biopterins; Dopamine Agents; Droxidopa; Humans; Levodopa; Nerve Tissue; Parkinson Disease; Pyridines; Serine | 1988 |
Noradrenergic influences on dopaminergic function and the pharmacology of dihydroxyphenylserine (DOPS): implication for Parkinson's disease.
Topics: Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Carbidopa; Dopamine; Droxidopa; Levodopa; Locus Coeruleus; Myocardium; Norepinephrine; Pargyline; Parkinson Disease; Serine; Stereoisomerism; Tyrosine | 1985 |
[Treatment of orthostatic hypotension by noradrenaline supplement].
Topics: Amyloidosis; Aromatic-L-Amino-Acid Decarboxylases; Catecholamines; Droxidopa; Humans; Hypotension, Orthostatic; Norepinephrine; Parkinson Disease; Polyneuropathies; Serine | 1985 |
6 trial(s) available for droxidopa and serine
Article | Year |
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Neuroendocrinological effects of L-threo-3, 4-dihydroxyphenylserine (DOPS), a putative norepinephrine precursor, on healthy volunteers.
Topics: Adult; Analysis of Variance; Brain; Droxidopa; Growth Hormone; Humans; Hydrocortisone; Kinetics; Male; Methoxyhydroxyphenylglycol; Prolactin; Serine; Thyrotropin | 1990 |
L-threo-3,4-dihydroxyphenylserine treatment for gait apraxia in parkinsonian patients.
Topics: Aged; Apraxias; Clinical Trials as Topic; Droxidopa; Drug Administration Schedule; Female; Gait; Humans; Male; Middle Aged; Parkinson Disease; Serine | 1989 |
Endogenous restoration of noradrenaline by precursor therapy in dopamine-beta-hydroxylase deficiency.
Topics: Adult; Blood Pressure; Clinical Trials as Topic; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Droxidopa; Female; Humans; Hypotension, Orthostatic; Norepinephrine; Serine | 1987 |
Memory effect of DL-threo-3,4-dihydroxyphenylserine (DOPS) in human Korsakoff's disease.
Topics: Alcohol Amnestic Disorder; Droxidopa; Hemodynamics; Humans; Male; Memory Disorders; Middle Aged; Psychometrics; Serine | 1988 |
L-threo-3, 4-dihydroxyphenylserine treatment of Parkinson's disease.
Topics: Aged; Clinical Trials as Topic; Droxidopa; Electromyography; Female; Humans; Levodopa; Male; Middle Aged; Parkinson Disease; Serine | 1985 |
DL-Threo-3,4-dihydroxyphenylserine does not exert a pressor effect in orthostatic hypotension.
Topics: Adult; Aged; Analysis of Variance; Blood Pressure; Chromatography, High Pressure Liquid; Droxidopa; Drug Evaluation; Female; Humans; Hypotension, Orthostatic; Male; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Normetanephrine; Posture; Serine | 1984 |
84 other study(ies) available for droxidopa and serine
Article | Year |
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Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters.
Topics: Amino Acid Sequence; Amino Acid Transport Systems; Amino Acid Transport Systems, Neutral; Animals; Anion Transport Proteins; Bacterial Proteins; Carrier Proteins; Cloning, Molecular; Escherichia coli Proteins; Female; Intestine, Small; Kinetics; Levodopa; Mice; Molecular Sequence Data; Oocytes; Phenylalanine; Rats; Recombinant Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Substrate Specificity; Tryptophan; Tyrosine; Xenopus laevis | 2001 |
[Synthesis of norepinephrine from 3,4-dihydroxyphenylserine by L-aromatic amino acid decarboxylase of the rat brain and kidneys].
Topics: Animals; Aorta; Brain; Decarboxylation; Dopa Decarboxylase; Droxidopa; Female; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Male; Muscle Contraction; Norepinephrine; Proteins; Rabbits; Rats; Serine; Stereoisomerism; Temperature; Time Factors | 1976 |
Characteristics of enzymic decarboxylation of L-threo-3,4-dihydroxyphenylserine using hog renal L-aromatic amino acid decarboxylase.
Topics: 5-Hydroxytryptophan; Animals; Decarboxylation; Dopa Decarboxylase; Droxidopa; Hydrogen-Ion Concentration; In Vitro Techniques; Kidney; Kinetics; Pyridoxal Phosphate; Serine; Stereoisomerism; Swine; Temperature; Time Factors | 1978 |
Positive chronotropic effect of threo-3,4-dihydroxyphenylserine as a precursor of noradrenaline in rat isolated atria.
Topics: Animals; Benserazide; Droxidopa; Heart Rate; In Vitro Techniques; Male; Methyltyrosines; Myocardium; Norepinephrine; Rats; Serine; Stereoisomerism; Stimulation, Chemical; Time Factors | 1978 |
Enzymatic decarboxylation of L-threo-3,4-dihydroxyphenylserine in rat heart.
Topics: Animals; Carboxy-Lyases; Decarboxylation; Dihydroxyphenylalanine; Droxidopa; Hydrogen-Ion Concentration; In Vitro Techniques; Kinetics; Male; Myocardium; Norepinephrine; Pyridoxal Phosphate; Pyrogallol; Rats; Serine; Temperature; Time Factors | 1978 |
A comparative study on the uptake and subsequent decarboxylation of monoamine precursors in cerebral microvessels.
Topics: 5-Hydroxytryptophan; Animals; Aromatic-L-Amino-Acid Decarboxylases; Benserazide; Blood-Brain Barrier; Brain; Cats; Cattle; Cricetinae; Decarboxylation; Dogs; Droxidopa; Female; Guinea Pigs; Haplorhini; Humans; Levodopa; Male; Mice; Microcirculation; Microscopy, Fluorescence; Rabbits; Rats; Serine; Species Specificity; Swine | 1979 |
The actions of dihydroxyphenylalanine and dihydroxyphenylserine on the sleep-wakefulness cycle of the rat after peripheral decarboxylase inhibition.
Topics: Activity Cycles; Animals; Benserazide; Carboxy-Lyases; Circadian Rhythm; Dihydroxyphenylalanine; Dose-Response Relationship, Drug; Droxidopa; Electroencephalography; Male; Rats; Serine; Sleep; Sleep Stages; Sleep, REM; Wakefulness | 1975 |
DDC-induced retrograde amnesias prevented by injections of dl-DOPS.
Topics: Amnesia, Retrograde; Animals; Avoidance Learning; Ditiocarb; Droxidopa; Humans; Male; Memory; Rats; Serine; Thiocarbamates; Time Factors | 1976 |
Lack of hypotensive and brain catecholamine depleting effects by erythro- and threo-alpha-methyl DOPS.
Topics: Animals; Blood Pressure; Brain Chemistry; Catecholamines; Droxidopa; Drug Interactions; Rats; Serine; Time Factors; Tyrosine | 1979 |
Inhibitory effect of (+)threo-3,4-dihydroxy-phenylserine (DOPS) on decarboxylation of (-)threo-dops.
Topics: Animals; Decarboxylation; Droxidopa; Isomerism; Kidney; Male; Rats; Serine; Time Factors | 1976 |
[Inhibition of harmaline induced tremor by L-threo-3, 4-dihydroxyphenylserine, an L-norepinephrine precursor].
Topics: Alkaloids; Animals; Brain Chemistry; Droxidopa; Drug Synergism; Harmaline; Isomerism; Locomotion; Male; Mice; Norepinephrine; Serine; Serotonin; Tremor; Tremorine; Tyrosine | 1976 |
The stereoisomers of 3,4-dihydroxyphenylserine as precursors of norepinephrine.
Topics: Animals; Behavior, Animal; Benserazide; Brain; Brain Chemistry; Carbidopa; Carboxy-Lyases; Dopamine; Droxidopa; Female; Histocytochemistry; In Vitro Techniques; Male; Myocardium; Norepinephrine; Rats; Serine; Serotonin; Stereoisomerism | 1975 |
[Formation of norapinephrine in the rat brain after administration of ((+)-erythro-3,4-dihydroxyphenylserine(author's transl)].
Topics: Animals; Brain; Capillaries; Carboxy-Lyases; Droxidopa; Female; Male; Microscopy, Fluorescence; Norepinephrine; Rats; Serine | 1975 |
[Synthesis of (-) or (+) -threo-3-(3,4-dihydroxyphenyl) serine and (-) or (+) -erythro-3-(3,4-dihydroxyphenyl)-serine].
Topics: Droxidopa; Methods; Serine; Stereoisomerism | 1975 |
Cardiovascular effects of D,L-threo-dihydroxyphenylserine in cats.
Topics: Animals; Blood Pressure; Carbidopa; Cats; Droxidopa; Female; Heart Rate; Male; Norepinephrine; Serine; Time Factors | 1975 |
Effects of 3,4-dihydroxyphenylserine on the concentration of brain noradrenaline and the level of plasma growth hormone of rats.
Topics: Animals; Brain; Brain Chemistry; Droxidopa; Growth Hormone; Male; Norepinephrine; Rats; Serine | 1975 |
[Analysis of L-threo-3, 4-dihydroxyphenylserine effect on motor and psychological symptoms in Parkinson's disease].
Topics: Aged; Aging; Droxidopa; Female; Humans; Male; Middle Aged; Parkinson Disease; Psychomotor Performance; Serine | 1991 |
Diuretic effects of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) in anesthetized rats.
Topics: Anesthesia; Animals; Aromatic Amino Acid Decarboxylase Inhibitors; Benserazide; Blood Pressure; Diuretics; Droxidopa; Glomerular Filtration Rate; Infusions, Intra-Arterial; Infusions, Intravenous; Male; Norepinephrine; Phentolamine; Rats; Rats, Inbred Strains; Renal Circulation; Serine | 1990 |
L-threodops increases extracellular norepinephrine levels in the brain: an in vivo study.
Topics: Animals; Carbidopa; Corpus Striatum; Droxidopa; Extracellular Space; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serine | 1990 |
[The effect of L-threo-DOPS on P-300 in parkinsonism].
Topics: Aged; Aged, 80 and over; Cognition; Droxidopa; Electrophysiology; Female; Humans; Male; Middle Aged; Parkinson Disease; Serine | 1990 |
D,L-threo-3, 4-DOPS enhances rapid eye movement sleep in patients with congenital dopamine beta-hydroxylase deficiency.
Topics: Adult; Brain; Dopamine beta-Hydroxylase; Droxidopa; Electroencephalography; Female; Humans; Receptors, Adrenergic; Serine; Sleep, REM | 1990 |
Effective treatment of pure akinesia with L-threo-3,4-dihydroxyphenylserine (DOPS): report of a case, with pharmacological considerations.
Topics: Droxidopa; Electromyography; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Methoxyhydroxyphenylglycol; Middle Aged; MMPI; Movement Disorders; Serine | 1985 |
Catecholamine metabolism during additional administration of DL-threo-3,4-dihydroxyphenylserine to patients with Parkinson's disease.
Topics: 3,4-Dihydroxyphenylacetic Acid; Aged; Catecholamines; Dopamine; Droxidopa; Female; Homovanillic Acid; Humans; Hydroxyindoleacetic Acid; Male; Middle Aged; Parkinson Disease, Secondary; Serine | 1989 |
[Postprandial hypotension.syncope in Shy-Drager syndrome and its treatment with oral L-DOPS].
Topics: Autonomic Nervous System Diseases; Droxidopa; Eating; Female; Humans; Hypotension, Orthostatic; Middle Aged; Serine; Shy-Drager Syndrome; Syncope | 1989 |
[Inhibitory effects of L-threo-DOPS on electroshock seizure in mice].
Topics: Animals; Anticonvulsants; Desipramine; Droxidopa; Drug Therapy, Combination; Electroshock; Male; Maprotiline; Mice; Mice, Inbred Strains; Nialamide; Seizures; Serine | 1989 |
Beneficial attenuating effect of L-threo-3,4-dihydroxyphenylserine on postural hypotension in anesthetized rats.
Topics: Anesthesia; Animals; Benzylamines; Blood Pressure; Droxidopa; Hexamethonium Compounds; Male; Phenylephrine; Posture; Rats; Rats, Inbred Strains; Serine; Sympathetic Nervous System; Tyramine | 1989 |
The effect of L-threo-DOPS on synaptic transmission to soleus motoneuron in normal subjects and patients with Parkinson's disease.
Topics: Adult; Aged; Droxidopa; Female; Humans; Levodopa; Male; Middle Aged; Motor Neurons; Muscles; Parkinson Disease; Reference Values; Serine; Synapses; Synaptic Transmission | 1987 |
[Bullous lesions in familial amyloid polyneuropathy and treatment with L-threo-3,4-dihydroxyphenylserine--with reference to peripheral circulation response against direct heat stimulation].
Topics: Adult; Amyloidosis; Droxidopa; Female; Hot Temperature; Humans; Male; Middle Aged; Peripheral Nervous System Diseases; Plethysmography; Serine; Skin; Skin Diseases, Vesiculobullous; Sympathetic Nervous System | 1988 |
Effect of DL-erythro-dihydroxyphenylserine on the locomotor activity of the mouse.
Topics: Amino Acids; Animals; Brain; Catecholamines; Dopamine; Droxidopa; Drug Interactions; Hydrazines; Male; Methamphetamine; Mice; Motor Activity; Norepinephrine; Reserpine; Serine; Serotonin | 1985 |
Diuretic effect of L-threo-3,4-dihydroxyphenylserine, a noradrenaline precursor, in rats and mice.
Topics: Animals; Benserazide; Carbidopa; Diuretics; Dose-Response Relationship, Drug; Droxidopa; Drug Interactions; Male; Mice; Norepinephrine; Rats; Rats, Inbred Strains; Serine; Species Specificity | 1986 |
Effect of unnatural noradrenaline precursor on sympathetic control and orthostatic hypotension in dopamine-beta-hydroxylase deficiency.
Topics: Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Dopamine beta-Hydroxylase; Dose-Response Relationship, Drug; Droxidopa; Epinephrine; Female; Humans; Hypotension, Orthostatic; Neurons; Norepinephrine; Serine; Stimulation, Chemical; Substrate Specificity; Sympathetic Nervous System; Tyramine | 1987 |
Inhibitory effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in the caudate nucleus.
Topics: Animals; Bromocriptine; Cats; Caudate Nucleus; Dopamine Agents; Droxidopa; Iontophoresis; Locus Coeruleus; Neural Pathways; Neurons; Norepinephrine; Reserpine; Serine | 1988 |
[L-threo-DOPS therapy and parkinsonism].
Topics: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; Antiparkinson Agents; Brain; Dopamine; Droxidopa; Humans; Levodopa; Norepinephrine; Parkinson Disease; Parkinson Disease, Secondary; Pyridines; Serine; Stereotaxic Techniques | 1986 |
Effect of L-threo-3,4-dihydroxyphenylserine chronic administration on cerebrospinal fluid and plasma free 3-methoxy-4-hydroxy-phenylglycol concentration in patients with Parkinson's disease.
Topics: Adult; Aged; Antiparkinson Agents; Carbidopa; Droxidopa; Drug Therapy, Combination; Glycols; Humans; Methoxyhydroxyphenylglycol; Middle Aged; Norepinephrine; Parkinson Disease; Serine | 1986 |
Reversal of the reserpine-induced ptosis by L-threo-3,4-dihydroxy-phenylserine (L-threo-DOPS), a (-)-norepinephrine precursor, and its potentiation by imipramine or nialamide.
Topics: Animals; Blepharoptosis; Brain Chemistry; Droxidopa; Drug Synergism; Imipramine; Injections, Intraventricular; Kinetics; Male; Mice; Nialamide; Norepinephrine; Reserpine; Serine | 1986 |
Inhibition of monoamine oxidase by 3,4-dihydroxyphenylserine.
Topics: Clorgyline; Droxidopa; Female; Humans; Kinetics; Mitochondria; Mitochondria, Liver; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Placenta; Pregnancy; Selegiline; Serine; Stereoisomerism | 1986 |
The effect of L-erythro-dihydroxyphenylserine injected into the lateral ventricle and the hypothalamus on the locomotor activity.
Topics: Animals; Anterior Hypothalamic Nucleus; Brain; Depression, Chemical; Droxidopa; Hypothalamus; Injections, Intraventricular; Male; Motor Activity; Rats; Rats, Inbred Strains; Serine | 1986 |
Reversal by L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS), a L-norepinephrine precursor of reserpine- or tetrabenazine-induced hypothermia.
Topics: Animals; Body Temperature; Brain; Brain Chemistry; Droxidopa; Injections; Male; Mice; Norepinephrine; Reserpine; Serine; Tetrabenazine; Time Factors | 1986 |
Effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS) on catecholamine levels in plasma and cerebrospinal fluid (CSF) in anesthetized rats.
Topics: Animals; Dose-Response Relationship, Drug; Droxidopa; Epinephrine; Kinetics; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serine; Urethane | 1987 |
Clinical effects of L-threo-3,4-dihydroxyphenylserine in cases of parkinsonism and pure akinesia.
Topics: Adult; Aged; Antiparkinson Agents; Droxidopa; Drug Evaluation; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Motor Skills; Parkinson Disease; Parkinson Disease, Secondary; Serine; Shy-Drager Syndrome | 1987 |
L-threo-3,4-dihydroxyphenylserine (DOPS) aldolase: a new enzyme cleaving DOPS into protocatechualdehyde and glycine.
Topics: Aldehyde Dehydrogenase; Aldehyde-Lyases; Benzaldehydes; Catechols; Cerebral Cortex; Droxidopa; Glycine; Humans; Serine; Subcellular Fractions; Substrate Specificity | 1987 |
Effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS), an immediate precursor of norepinephrine, on the cerebral blood flow in rats.
Topics: Animals; Cerebrovascular Circulation; Corpus Striatum; Droxidopa; Hippocampus; Male; Norepinephrine; Propranolol; Rats; Rats, Inbred Strains; Serine | 1987 |
Studies on the central action of L-threo-3,4-dihydroxyphenyl-serine (L-threo-DOPS) in FLA-63-treated mice.
Topics: Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Droxidopa; Drug Interactions; Heart; Imidazoles; Kidney; Kinetics; Male; Mice; Mice, Inbred Strains; Motor Activity; Myocardium; Nialamide; Norepinephrine; Serine | 1987 |
Effect of L-threo-3,4-dihydroxyphenylserine(L-threo-DOPS) on brain and serum MHPG levels in mice: evidence for NE formation in CNS.
Topics: Animals; Benserazide; Brain; Brain Chemistry; Dose-Response Relationship, Drug; Droxidopa; Glycols; Male; Methoxyhydroxyphenylglycol; Mice; Norepinephrine; Serine | 1987 |
[Clinical effects of oral L-threo-3,4-dihydroxyphenylserine on orthostatic hypotension in patients with Shy-Drager syndrome].
Topics: Adult; Aged; Autonomic Nervous System Diseases; Droxidopa; Humans; Hypotension, Orthostatic; Male; Middle Aged; Serine; Shy-Drager Syndrome | 1987 |
Effects of L-threo-3,4-dihydroxyphenylserine on efflux of monoamines and acetylcholine in guinea pig brain.
Topics: Acetylcholine; Animals; Brain; Dopamine; Droxidopa; Electric Stimulation; Female; Guinea Pigs; In Vitro Techniques; Male; Norepinephrine; Serine; Serotonin | 1987 |
Studies on the activity of L-threo-3,4-dihydroxyphenylserine (L-DOPS) as a catecholamine precursor in the brain. Comparison with that of L-dopa.
Topics: Animals; Aromatic-L-Amino-Acid Decarboxylases; Brain; Catecholamines; Dopamine; Droxidopa; Kinetics; Levodopa; Male; Methoxyhydroxyphenylglycol; Mice; Nialamide; Norepinephrine; Protein Precursors; Rats; Rats, Inbred Strains; Serine; Substrate Specificity | 1987 |
Uptake of L-threo-dihydroxyphenylserine into human brain synaptosomes.
Topics: Amino Acids; Brain; Chromatography, High Pressure Liquid; Droxidopa; Humans; Kinetics; Serine; Synaptosomes | 1987 |
Effects of L-threo-DOPS, an L-noradrenaline precursor, on locus coeruleus-originating neurons in spinal trigeminal nucleus.
Topics: Action Potentials; Animals; Cats; Droxidopa; Electric Stimulation; Locus Coeruleus; Norepinephrine; Reaction Time; Serine; Sotalol; Trigeminal Nucleus, Spinal | 1987 |
[A case with acute pandysautonomia with aseptic meningitis--Pathophysiological and therapeutic study].
Topics: Acute Disease; Adult; Autonomic Nervous System Diseases; Droxidopa; Humans; Hypotension, Orthostatic; Male; Meningitis; Meningitis, Aseptic; Serine; Syndrome | 1987 |
Increase in norepinephrine turnover after tyrosine or DL-threo-3,4-dihydroxyphenylserine (DL-threo-DOPS).
Topics: Animals; Benzylamines; Brain; Droxidopa; Male; Methoxyhydroxyphenylglycol; Mice; Norepinephrine; Serine; Tyrosine | 1988 |
Effects of L-erythro-3, 4-dihydroxyphenylserine on sleep-wakefulness patterns and concentrations of brain catecholamines and serotonin in rats.
Topics: Animals; Brain; Catecholamines; Droxidopa; Histocytochemistry; Male; Rats; Rats, Inbred Strains; Serine; Serotonin; Sleep; Wakefulness | 1987 |
Effect of L-threo-3,4-dihydroxyphenylserine on regional cerebral blood flow in patients with Parkinson's disease.
Topics: Adult; Aged; Blood Pressure; Cerebrovascular Circulation; Droxidopa; Female; Humans; Male; Middle Aged; Parkinson Disease; Regional Blood Flow; Serine | 1988 |
Effect of L-threo-3,4-dihydroxyphenylserine on muscle sympathetic nerve activities in Shy-Drager syndrome.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Droxidopa; Efferent Pathways; Humans; Male; Middle Aged; Muscles; Norepinephrine; Serine; Shy-Drager Syndrome; Sympathetic Nervous System; Tibial Nerve | 1988 |
[The effective of L-threo-3,4-dihydroxyphenylserine (L-threo-DOPS) in hypersomnia and subcortical dementia caused by bilateral medial thalamic and midbrain infarcts].
Topics: Aged; Cerebral Infarction; Dementia; Disorders of Excessive Somnolence; Droxidopa; Female; Humans; Mesencephalon; Serine; Sleep Wake Disorders; Thalamus | 1988 |
Determination of D,L-threo-3,4-dihydroxyphenylserine and of the D- and L-enantiomers in human plasma and urine.
Topics: Acetylcysteine; Droxidopa; Humans; o-Phthalaldehyde; Serine; Spectrometry, Fluorescence; Stereoisomerism | 1988 |
Studies of neurocirculatory effects of long-term L-threo-3,4-dihydroxyphenylserine administration in a patient with familial amyloidotic polyneuropathy.
Topics: Amyloidosis; Blood Circulation; Blood Pressure; Consciousness; Droxidopa; Female; Heart Rate; Humans; Hypotension, Orthostatic; Middle Aged; Nervous System; Nervous System Diseases; Serine | 1988 |
Effects of L-threo-dihydroxyphenylserine on spinal reflexes and decerebrate rigidity in rats.
Topics: Animals; Benserazide; Blood Pressure; Clorgyline; Decerebrate State; Droxidopa; Male; Motor Activity; Rats; Rats, Inbred Strains; Reflex; Serine; Spinal Cord | 1988 |
[The influences of intracerebroventricular injection of dihydroxyphenylserine in rabbits and electrical stimulation of locus coeruleus in rats upon the increase of electro-acupuncture-induced immune functions].
Topics: Acupuncture Therapy; Adrenergic Fibers; Animals; Droxidopa; Electric Stimulation; Immunoglobulins; Injections, Intraventricular; Locus Coeruleus; Lymphocyte Activation; Male; Muramidase; Neurons; Rabbits; Rats; Rats, Inbred Strains; Serine | 1988 |
[Metrizamide encephalopathy in a child with hydrocephalus--effects of L-threo-DOPS on persistent disturbance of consciousness and L-dopa on extrapyramidal symptoms].
Topics: Basal Ganglia Diseases; Brain; Brain Diseases; Child; Cognition Disorders; Consciousness Disorders; Droxidopa; Electroencephalography; Extravasation of Diagnostic and Therapeutic Materials; Female; Humans; Hydrocephalus; Levodopa; Metrizamide; Serine; Tomography, X-Ray Computed | 1988 |
[Improvement in cardiovascular autonomic dysfunction of a patient with OPCA with L-threo-3,4-dihydroxyphenylserine].
Topics: Autonomic Nervous System; Droxidopa; Female; Humans; Hypotension, Orthostatic; Middle Aged; Olivopontocerebellar Atrophies; Serine; Spinocerebellar Degenerations | 1988 |
d,l-threo-3,4-dihydroxyphenylserine restores sympathetic control and cures orthostatic hypotension in dopamine beta-hydroxylase deficiency.
Topics: Blood Pressure; Dopamine; Dopamine beta-Hydroxylase; Droxidopa; Heart Rate; Humans; Hypotension, Orthostatic; Norepinephrine; Serine; Sympathetic Nervous System | 1988 |
[A case of diabetic orthostatic hypotension effectively managed with L-dops (L-threo-3,4-dihydroxyphenylserine)].
Topics: Cimetidine; Diabetic Neuropathies; Diarrhea; Diphenhydramine; Droxidopa; Humans; Hypotension, Orthostatic; Male; Middle Aged; Serine | 1987 |
Mass spectrometric measurements of norepinephrine synthesis in man from infusion of stable isotope-labelled L-threo-3,4-dihydroxyphenylserine.
Topics: Atrophy; Brain Diseases; Cerebellum; Droxidopa; Gas Chromatography-Mass Spectrometry; Humans; Hypotension, Orthostatic; Norepinephrine; Olivary Nucleus; Parkinson Disease; Pons; Serine | 1985 |
Treatment of orthostatic hypotension in Shy-Drager syndrome with DL-threo-3,4-dihydroxyphenylserine: a case report.
Topics: Autonomic Nervous System Diseases; Blood Pressure; Carbidopa; Droxidopa; Drug Combinations; Humans; Hypotension, Orthostatic; Male; Middle Aged; Norepinephrine; Phenylephrine; Serine; Shy-Drager Syndrome; Valsalva Maneuver | 1985 |
The effects of L-threo-dihydroxyphenylserine on norepinephrine metabolism in rat brain.
Topics: alpha-Methyltyrosine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain; Carbidopa; Droxidopa; Fusaric Acid; Male; Methoxyhydroxyphenylglycol; Methyltyrosines; Norepinephrine; Rats; Rats, Inbred Strains; Reserpine; Serine | 1985 |
DL-threo-DOPS as a precursor of noradrenaline.
Topics: alpha-Methyltyrosine; Animals; Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; Brain Chemistry; Carbidopa; Dopamine; Droxidopa; Levodopa; Male; Methyltyrosines; Myocardium; Norepinephrine; Pargyline; Rats; Rats, Inbred Strains; Reserpine; Serine; Stereotyped Behavior | 1985 |
Pressor effect of L-threo-3,4-dihydroxyphenylserine in rats.
Topics: Administration, Oral; Animals; Blood Pressure; Droxidopa; Epinephrine; Hydroxydopamines; Injections, Intravenous; Injections, Intraventricular; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serine; Stereoisomerism; Sympathectomy, Chemical | 1981 |
Age-related changes in the chronotropic effect and the enzymic decarboxylation of L-threo-3,4-dihydroxphenylserine in the rat heart.
Topics: Age Factors; Animals; Decarboxylation; Droxidopa; Female; Heart Rate; In Vitro Techniques; Male; Norepinephrine; Rats; Rats, Inbred Strains; Serine; Stereoisomerism | 1981 |
Increased brain concentration of homovanillic acid in rats treated with threo-3,4-dihydroxyphenylserine.
Topics: Animals; Benserazide; Brain Chemistry; Droxidopa; Homovanillic Acid; Male; Norepinephrine; Phenylacetates; Rats; Rats, Inbred Strains; Serine | 1982 |
Therapy of malignant hamster insulinomas with monoamine precursors.
Topics: 5-Hydroxytryptophan; Adenoma, Islet Cell; Animals; Cricetinae; Dopamine; Droxidopa; Levodopa; Neoplasms, Experimental; Norepinephrine; Pancreatic Neoplasms; Pargyline; Serine; Serotonin | 1981 |
Orthostatic hypotension in familial amyloid polyneuropathy: treatment with DL-threo-3,4-dihydroxyphenylserine.
Topics: Adult; Amyloidosis; Blood Pressure; Droxidopa; Female; Humans; Hypotension, Orthostatic; Male; Middle Aged; Norepinephrine; Peripheral Nervous System Diseases; Serine; Tyrosine | 1981 |
The simultaneous determination of 3,4-dihydroxyphenyl-ethylene glycol, 3,4-dihydroxyphenylacetic acid and catecholamines in brain tissue by high performance liquid chromatography with electrochemical detection.
Topics: 3,4-Dihydroxyphenylacetic Acid; Animals; Brain; Brain Chemistry; Catecholamines; Chromatography, High Pressure Liquid; Cold Temperature; Dopamine; Droxidopa; Electrochemistry; Epinephrine; Female; Kinetics; Norepinephrine; Phenylacetates; Physical Exertion; Rats; Rats, Inbred Strains; Serine | 1983 |
DL-3,4-threo-DOPS in Parkinson's disease: effects on orthostatic hypotension and dizziness.
Topics: Aged; Antiparkinson Agents; Benserazide; Blood Pressure; Dizziness; Droxidopa; Drug Therapy, Combination; Female; Humans; Hypotension, Orthostatic; Long-Term Care; Male; Norepinephrine; Parkinson Disease; Serine | 1983 |
DL-threo-3,4-dihydroxyphenylserine for freezing symptom in parkinsonism.
Topics: Aged; Antiparkinson Agents; Blood-Brain Barrier; Carboxy-Lyases; Dopamine; Droxidopa; Drug Therapy, Combination; Female; Humans; Levodopa; Male; Middle Aged; Norepinephrine; Parkinson Disease; Serine | 1984 |
Influence of levodopa, apomorphine and 3,4-dihydroxyphenylserine (DOPS) on strychnine-induced seizures in mice.
Topics: Animals; Apomorphine; Droxidopa; Levodopa; Mice; Phentolamine; Propranolol; Seizures; Serine; Strychnine | 1984 |
Improvement in freezing phenomenon of Parkinson's disease after DL-threo-3, 4-dihydroxyphenylserine.
Topics: Aged; Benserazide; Droxidopa; Gait; Humans; Levodopa; Male; Methoxyhydroxyphenylglycol; Parkinson Disease; Serine | 1984 |
[D,L-threo-3,4-dihydroxyphenylserine (D,L-threo-DOPS) treatment on the patients with Parkinson's disease or pure akinesia].
Topics: Aged; Droxidopa; Female; Gait; Humans; Male; Middle Aged; Movement Disorders; Muscle Rigidity; Parkinson Disease; Serine; Tremor | 1984 |
Treatment of parkinsonism with L-threo-3,4-dihydroxyphenylserine: a pharmacokinetic study.
Topics: Adult; Aged; Carbidopa; Cerebellar Diseases; Droxidopa; Female; Humans; Kinetics; Male; Middle Aged; Olivary Nucleus; Parkinson Disease; Pons; Serine | 1984 |
Effect of infused L-threo-3,4-dihydroxyphenylserine on adrenergic activity in patients with familial amyloid polyneuropathy.
Topics: Adult; Amyloidosis; Autonomic Nervous System; Blood Pressure; Dopamine beta-Hydroxylase; Droxidopa; Female; Humans; Infusions, Parenteral; Male; Middle Aged; Nervous System Diseases; Norepinephrine; Octopamine; Pulse; Serine; Stereoisomerism; Sympathetic Nervous System | 1980 |
Effects of amino acid precursors on catecholamine synthesis in the brain.
Topics: Amino Acids; Animals; Brain; Catecholamines; Dihydroxyphenylalanine; Droxidopa; Male; Rats; Rats, Inbred Strains; Serine; Tyrosine | 1981 |
Pharmacokinetic studies of oral L-threo-3,4-dihydroxyphenylserine in normal subjects and patients with familial amyloid polyneuropathy.
Topics: Adult; Amyloidosis; Blood Pressure; Dopamine beta-Hydroxylase; Droxidopa; Female; Humans; Intestinal Absorption; Kinetics; Male; Metanephrine; Middle Aged; Nervous System Diseases; Norepinephrine; Normetanephrine; Serine; Time Factors | 1982 |
[Effect of a decarboxylase inhibitor on the effects of dopa & dops on blood pressure].
Topics: Antiparkinson Agents; Blood Pressure; Blood Pressure Determination; Carboxy-Lyases; Dihydroxyphenylalanine; Droxidopa; Enzyme Inhibitors; Humans; Lyases; Serine | 1957 |
Adrenaline carboxylic acid (N-methyl-beta-(3:4-dihydroxyphenyl) serine).
Topics: Adrenal Glands; Droxidopa; Serine; Tissue Extracts | 1946 |