dronabinol has been researched along with anandamide in 229 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 65 (28.38) | 18.2507 |
| 2000's | 94 (41.05) | 29.6817 |
| 2010's | 61 (26.64) | 24.3611 |
| 2020's | 9 (3.93) | 2.80 |
| Authors | Studies |
|---|---|
| Blond, O; Briley, EM; Felder, CC; Joyce, KE; Lai, Y; Ma, AL; Mackie, K; Mansouri, J; Mitchell, RL | 1 |
| Abood, ME; Compton, DR; Martin, BR; Showalter, VM | 1 |
| Banner, WK; Martin, BR; Razdan, RK; Ryan, WJ; Wiley, JL | 1 |
| Bianchi, A; Cruciani, G; Fichera, M; Musumarra, G | 1 |
| Fowler, CJ; Lambert, DM | 1 |
| Nilius, B; Owsianik, G; Talavera, K; Voets, T | 1 |
| Gynther, J; Järvinen, T; Lahtela-Kakkonen, M; Laitinen, JT; Nevalainen, T; Parkkari, T; Poso, A; Salo, OM; Savinainen, JR | 1 |
| Drmota, T; Elebring, T; Greasley, PJ; Hermansson, NO; Hjorth, S; Larsson, N; Leonova, J; Nilsson, K; Ryberg, E; Sjögren, S | 1 |
| Bradshaw, HB; Dunn, E; McHugh, D; Page, J | 1 |
| Buzard, DJ; Han, S; Jones, RM; Thatte, J | 1 |
| Asproni, B; Cichero, E; Deiana, V; Deligia, F; Fernández-Ruiz, J; Fossa, P; García-Arencibia, M; Gómez-Cañas, M; Muñoz, E; Murineddu, G; Pazos, MR; Pinna, GA | 1 |
| Chung, S; Dangott, LJ; Huang, H; Kier, AB; Landrock, D; Landrock, KK; Li, S; Martin, GG; McIntosh, AL; Schroeder, F | 1 |
| Barinaga, M | 1 |
| Fuentes, JA; Ruiz-Gayo, M; Vela, G | 1 |
| Das, SK; Dey, SK; Paria, BC | 1 |
| Cebeira, M; Fernández-Ruiz, JJ; García, L; Ramos, JA; Romero, J | 1 |
| Burstein, SH; Hunter, SA | 2 |
| Chakraborty, I; Das, SK; Dey, SK; Paria, BC | 1 |
| Cebeira, M; Fernández-Ruiz, JJ; García, L; Ramos, JA; Romero, J; Zadrozny, D | 1 |
| Martin, BR; Tóth, BE; Wenger, T | 1 |
| Balster, R; Martin, B; Wiley, J | 1 |
| Dunlow, LD; Patrick, GS; Razdan, RK; Welch, SP | 1 |
| Barg, J; Fride, E; Heldman, E; Levy, R; Mechoulam, R; Saya, D; Vogel, Z | 1 |
| Compton, DR; Martin, BR; Mechoulam, R; Razdan, RK; Smith, PB; Welch, SP | 1 |
| Goldstein, E; Mechoulam, R; Schuel, H; Zimmerman, AM; Zimmerman, S | 1 |
| Pertwee, RG; Wickens, AP | 1 |
| Feldman, S; Mechoulam, R; Weidenfeld, J | 1 |
| Griffin, G; Pertwee, RG; Stevenson, LA | 1 |
| Fride, E; Mechoulam, R | 2 |
| Iversen, LL | 1 |
| Adams, IB; Martin, BR; Mascarella, SW; Razdan, RK; Thomas, BF | 1 |
| Fride, E | 1 |
| Ellis, EF; Moore, SF; Willoughby, KA | 1 |
| Burstein, SH; Wright, GE; Young, JK | 1 |
| Ellis, EF; Martin, BR; Shivachar, AC | 1 |
| Guyenet, PG; Huangfu, D; Kunos, G; Lake, KD; Varga, K | 1 |
| Poling, JS; Rogawski, MA; Salem, N; Vicini, S | 1 |
| de Miguel, R; Fernández-Ruiz, JJ; García-Palomero, E; Ramos, JA; Romero, J | 1 |
| Mechoulam, R | 2 |
| Bloom, AS; Edgemond, WS; Moldvan, JC | 1 |
| Welch, SP | 1 |
| Allain, N; Anger, JP; Berdyshev, EV; Boichot, E; Germain, N; Lagente, V | 1 |
| Fernández-Ruiz, JJ; Makriyannis, A; Muñoz, RM; Ramos, JA; Romero, J; Villanua, MA | 1 |
| Burkey, RT; Nation, JR | 1 |
| Fragkakis, G; Giannikou, P; Wenger, T; Yiannikakis, N | 1 |
| Brodkin, J; Moerschbaecher, JM | 1 |
| Burkey, TH; Consroe, P; Ehlert, FJ; Hosohata, Y; Quock, RM; Roeske, WR; Yamamura, HI | 1 |
| Balster, RL; Golden, KM; Martin, BR; Razdan, RK; Ryan, WJ; Wiley, JL | 1 |
| Bickler, PE; Bornheim, LM; Gray, AT; Hampson, AJ; Hansen, BM; Leonoudakis, DJ; Scanziani, M; Yost, CS | 1 |
| Cardounel, A; Kalimi, M; Qureshi, J; Saady, M | 1 |
| Axelrod, J; Felder, CC | 1 |
| Fujimori, K; Lowe, J; Smith, FL; Welch, SP | 1 |
| Andrenyak, DM; Deng, H; Dey, SK; Ma, W; Makriyannis, A; Moody, DE; Paria, BC; Schmid, HH; Schmid, PC | 1 |
| Beninger, RJ; Mallet, PE | 2 |
| Bridgen, DT; Kunos, G; Varga, K; Wagner, JA | 1 |
| Arnold, JC; Hunt, GE; McGregor, IS; Topple, AN; Weber, MF | 1 |
| Martin, BR; Razdan, RK; Ryan, WJ; Wiley, JL | 1 |
| Burstein, SH; Pestonjamasp, VK | 1 |
| Arthur, DB; LaVecchia, KL; Lichtman, AH; Martin, BR; Neviaser, ST; Wiley, JL; Wilson, DM | 1 |
| Hiley, CR; White, R | 1 |
| Di Marzo, V; Fride, E; Mechoulam, R | 1 |
| Bonhaus, DW; Chang, LK; Kwan, J; Martin, GR | 1 |
| Goparaju, SK; Katayama, K; Kurahashi, Y; Suzuki, H; Ueda, N; Yamamoto, S | 1 |
| Baba, N; Ishima, Y; Kodaka, T; Kondo, S; Miyashita, T; Nakane, S; Seki, C; Sugiura, T; Suhara, Y; Takayama, H; Waku, K | 1 |
| Járai, Z; Kunos, G; Varga, K; Wagner, JA | 1 |
| Kamata, R; Kobayashi, H; Matsusaka, N; Saito, S; Sato, I; Suzuki, T; Tsuda, S | 1 |
| Busse, R; Fleming, I; Popp, R; Schermer, B | 1 |
| Ben-Shabat, S; Mechoulam, R | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Martin, BR; Melck, D | 1 |
| Göthert, M; Likungu, J; Molderings, GJ | 1 |
| Bonner, TI; Buckley, NE; Compton, DR; Járai, Z; Kunos, G; Lake, KD; Martin, BR; Mezey, E; Razdan, RK; Varga, K; Wagner, JA; Zimmer, A; Zimmer, AM | 1 |
| Barker, EL; Blakely, RD; Day, TA; Rakhshan, F | 1 |
| Eads, M; Embrey, JP; Houser, SJ; Welch, SP | 1 |
| Angus, JA; Lay, L; Wright, CE | 1 |
| Berrendero, F; Bisogno, T; Di Marzo, V; Fernández-Ruiz, JJ; González, S; Manzanares, J; Milone, A; Ramos, JA; Wenger, T | 1 |
| Berrendero, F; Bisogno, T; Cavaliere, P; Cebeira, M; Di Marzo, V; Fernández-Ruiz, JJ; González, S; Ramos, JA; Romero, J | 1 |
| Gómez del Pulgar , T; Guzmán, M; Velasco, G | 1 |
| Colleoni, M; Costa, B | 1 |
| Hillard, CJ | 1 |
| Song, ZH; Zhong, M | 1 |
| Friedman, H; Klein, TW; Lane, B; Newton, CA | 1 |
| Breivogel, CS; Bridgen, DT; Di Marzo, V; Martin, BR; Razdan, RK; Tao, Q; Zimmer, A; Zimmer, AM | 1 |
| D'Souza, DC; Kosten, TR | 1 |
| Kim, D; Thayer, SA | 1 |
| Bueb, JL; Lambert, DM; Tschirhart, EJ | 1 |
| Bisogno, T; Breuer, A; Di Marzo, V; Fride, E; Ginzburg, Y; Mechoulam, R | 1 |
| Bátkai, S; Járai, Z; Kunos, G; Wagner, JA | 1 |
| Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A | 1 |
| Kato, H; Kurihara, J; Nakane, S; Nishigaki, M; Okubo, Y; Sugiura, T; Suzuki, S; Takata, Y; Waku, K | 1 |
| Gurwitz, D; Weizman, A | 1 |
| Darmani, NA | 1 |
| Crocker, PJ; Jefferson, RG; Martin, BR; Razdan, RK; Thomas, BF; Wiley, JL; Williams, W; Winckler, R | 1 |
| Mechoulam, R; Panikashvili, D; Shohami, E | 1 |
| Guaza, C; Molina-Holgado, E; Molina-Holgado, F; Rothwell, NJ | 1 |
| Gerdeman, GL; Lovinger, DM; Ronesi, J | 1 |
| Kirkham, TC; Williams, CM | 1 |
| Bari, M; Battista, N; Bernardi, G; Calabresi, P; Centonze, D; Finazzi-Agrò, A; Gubellini, P; Maccarrone, M; Picconi, B | 1 |
| Anikwue, R; Huffman, JW; Martin, ZL; Welch, SP | 1 |
| Egan, RW; Hey, JA; Jia, Y; McLeod, RL; Parra, LE; Wang, X | 1 |
| Higgs, S; Kirkham, TC; Williams, CM | 1 |
| Huang, JS; Lian, ML; Yan, MS | 1 |
| Chow, SS; Lau, AH | 1 |
| Bisogno, T; De Petrocellis, L; Di Marzo, V; Hermann, H; Lutz, B; Schiano Moriello, A | 1 |
| Lichtman, AH; Mechoulam, R | 1 |
| Broderick, VM; Dennedy, MC; Friel, AM; Houlihan, DD; Morrison, JJ; Smith, T | 1 |
| Engler, C; Feuerstein, TJ; Steffens, M; Zentner, J | 1 |
| Szendrei, K | 1 |
| Ambrosio, E; Arévalo, C; Cascio, MG; Di Marzo, V; Fernández-Ruiz, J; González, S; Hernández, M; Nicanor, C; Ramos, JA | 1 |
| Battista, N; Bernardi, G; Calabresi, P; Centonze, D; Finazzi-Agrò, A; Maccarrone, M; Mercuri, NB; Rossi, S | 1 |
| Kraft, B; Kress, HG; Wintersberger, W | 1 |
| Do, Y; McKallip, RJ; Nagarkatti, M; Nagarkatti, PS | 1 |
| Karp, NE; Kulasegram, S; LaVecchia, KL; Mahadevan, A; Martin, BR; Razdan, RK; Wiley, JL | 1 |
| Bátkai, S; Bukoski, RD; Harvey-White, J; Kunos, G; Liu, J; Mackie, K; Offertáler, L; Osei-Hyiaman, D; Pacher, P; Radaeva, S; Rudd, MA | 1 |
| Kendall, DA; O'Sullivan, SE; Randall, MD | 2 |
| Lam, PM; Lambert, DG; McDonald, J | 1 |
| Dewey, WL; Razdan, RK; Smith, FL; Wiley, JL | 1 |
| Bátkai, S; Brassai, A; Cravatt, BF; Harvey-White, J; Járai, Z; Kunos, G; Liu, J; Offertáler, L; Osei-Hyiaman, D; Pacher, P | 1 |
| Ashton, CH; Gallagher, P; Moore, PB; Young, AH | 1 |
| Bannon, AW; Cravatt, BF; Depetrillo, M; Harvey-White, J; Kuhar, MJ; Kunos, G; Mackie, K; Osei-Hyiaman, D; Palkovits, M | 1 |
| Mackie, K; Straiker, A | 1 |
| Baillie, G; Pertwee, RG; Price, MR; Ross, RA; Stevenson, LA; Thomas, A; Wease, KN | 1 |
| Bai, G; Ji, SP; Jiang, W; Van Cleemput, J; Xiao, L; Zhang, X; Zhang, Y | 1 |
| Hejazi, N; Oz, M; Sun, H; Ye, JH; Zhang, L; Zhou, C | 1 |
| Bambico, FR; Bortolato, M; Campolongo, P; Cassano, T; Cuomo, V; Debonnel, G; Duranti, A; Gobbi, G; Goldberg, SR; Mangieri, R; Mor, M; Morgese, MG; Piomelli, D; Solinas, M; Tarzia, G; Tontini, A; Trezza, V | 1 |
| Bari, M; Battista, N; Fezza, F; Gasperi, V; Maccarrone, M | 1 |
| Fowler, CJ; Jacobsson, SO; Nilsson, O | 1 |
| Dehghani, F; Ghadban, C; Koch, M; Korf, HW; Kreutz, S | 1 |
| Cravatt, BF; Lichtman, AH; Niyuhire, F; Varvel, SA; Wise, LE | 1 |
| Braida, D; Limonta, V; Malabarba, L; Sala, M; Zani, A | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Piomelli, D; Solinas, M; Tanda, G; Vadivel, SK; Wertheim, CE; Yasar, S | 1 |
| Fratta, W; Goldberg, SR; Scherma, M; Solinas, M; Tanda, G; Wertheim, CE | 1 |
| Drysdale, AJ; Pertwee, RG; Platt, B; Ryan, D | 1 |
| Fisar, Z; Velenovská, M | 1 |
| Buettner, R; Cravatt, B; Date, R; Di Marzo, V; Gaffal, E; Karsak, M; Mechoulam, R; Petrosino, S; Rehnelt, J; Schlicker, E; Starowicz, K; Steuder, R; Tüting, T; Wang-Eckhardt, L; Werner, S; Zimmer, A | 1 |
| Fischbach, T; Greffrath, W; Nawrath, H; Treede, RD | 1 |
| Bari, M; Battistini, L; Bernardi, G; Bernardini, S; Centonze, D; De Chiara, V; Fezza, F; Furlan, R; Maccarrone, M; Martino, G; Prosperetti, C; Rossi, S | 1 |
| Connor, M; Roberts, LA; Ross, HR | 1 |
| Adler, MW; Eisenstein, TK; Gaughan, JP; Meissler, JJ; Wilson, Q | 1 |
| Després, JP | 1 |
| Cannavacciulo, R; Cravatt, BF; Lichtman, AH; Martin, BF; Wise, LE | 1 |
| Bourne, C; Mahadevan, A; Martin, BR; Razdan, RK; Roy, S; Thomas, BF; Wiley, JL | 1 |
| Alexander, SP; Bennett, AJ; Garle, MJ; Gibson, CL; Hewitt, K; Kendall, DA; Murphy, SP; Sun, Y | 1 |
| Alexander, SP; Athanasiou, A; Bagiokou, D; Bates, TE; Bradshaw, TD; Calabrese, V; Clarke, AB; Clothier, RH; Constantinescu, CS; Fang, L; Kendall, DA; Kumaran, NM; Lobo, DN; Loesch, A; Smith, PA; Turner, AE; Vakilpour, S; Westwell, AD | 1 |
| Cravatt, BF; Hegde, S; Hegde, VL; Hofseth, LJ; Nagarkatti, M; Nagarkatti, PS | 1 |
| Araújo, JR; Azevedo, I; Gonçalves, P; Martel, F | 1 |
| Pertwee, RG | 1 |
| Järbe, TU; Li, C; Liu, Q; Makriyannis, A | 1 |
| McMahon, LR | 1 |
| Artmann, A; Devi, LA; Ellgren, M; Gupta, A; Hansen, HS; Hansen, SH; Hurd, YL; Tkalych, O | 1 |
| Bilkei-Gorzo, A; Göthert, M; Markert, A; Rácz, I; Stamer, F; Zimmer, A | 1 |
| Bortolato, M; Chefer, SI; Clapper, JR; Goldberg, SR; Justinova, Z; King, AR; Mangieri, RA; Mukhin, AG; Piomelli, D; Redhi, GH; Yasar, S | 1 |
| Araújo, JR; Gonçalves, P; Martel, F | 1 |
| Kinsey, SG; Lichtman, AH; Schlosburg, JE | 1 |
| Crestani, F; Piva, B; Shaladi, AM; Tartari, S | 1 |
| Mahmud, A; Nagy, I; Paule, CC; Santha, P | 1 |
| Bushell, K; Huffman, JW; Martin, BR; Vann, RE; Warner, JA; Wiley, JL | 1 |
| Nomikos, GG; Panagis, G; Vlachou, S | 1 |
| Floresco, SB; Gorzalka, BB; Hill, MN; Hillard, CJ; McLaughlin, RJ; Morrish, AC; Viau, V | 1 |
| Bari, M; Battistini, L; Bernardi, G; Buttari, F; Cencioni, MT; Centonze, D; Codecà, C; Fiore, S; Koch, G; Maccarrone, M; Mori, F; Rossi, S | 1 |
| Burston, JJ; Wiley, JL | 1 |
| Izzo, AA; Sharkey, KA | 1 |
| Goldberg, SR; Solinas, M; Tanda, G; Wertheim, CE | 1 |
| Makwana, R; Molleman, A; Parsons, ME | 1 |
| Baufreton, J; Manuel, I; Morera-Herreras, T; Rodriguez-Puertas, R; Ruiz-Ortega, JA; Taupignon, A; Ugedo, L | 1 |
| Abdullah, RA; Cravatt, BF; Falenski, KW; Lichtman, AH; Schlosburg, JE; Selley, DE; Sim-Selley, LJ; Smith, TH; Thorpe, AJ | 1 |
| Fisar, Z | 1 |
| Haskó, G; Liaudet, L; Mackie, K; Mukhopadhyay, P; Pacher, P; Rajesh, M | 1 |
| Mlynarczyk, M; Nagy, I; Paule, CC; Soneji, ND | 1 |
| Bäckhed, F; Cani, PD; Delzenne, NM; Lambert, DM; Muccioli, GG; Naslain, D; Reigstad, CS | 1 |
| Bagavandoss, P; Grimshaw, S | 1 |
| Brett, RR; Kane, KA; Kennedy, S; Mair, KM; Pyne, NJ; Pyne, S; Robinson, E | 1 |
| Linazasoro, G; Morera-Herreras, T; Ruiz-Ortega, JA; Ugedo, L | 1 |
| Ferré, S; Franco, R; Goldberg, SR; Justinová, Z; Mascia, P; Müller, CE; Quarta, D; Redhi, GH; Stroik, J; Yasar, S | 1 |
| Gamage, TF; Grainger, DB; Nguyen, TK; Vann, RE; Walentiny, DM; Warner, JA; Wiley, JL | 1 |
| Bombolewski, R; Debinski, A; Filipek, S; Ghoshdastider, U; Jozwiak, K; Kolinski, M; Latek, D; Plazinska, A | 1 |
| McMahon, LR; Stewart, JL | 1 |
| Bernardi, G; Cavasinni, F; Centonze, D; Cravatt, BF; De Chiara, V; Furlan, R; Lutz, B; Maccarrone, M; Martino, G; Motta, C; Musella, A; Muzio, L; Rossi, S; Studer, V | 1 |
| Becker, C; Engel, MA; Izydorczyk, I; Mueller-Tribbensee, SM; Neurath, MF; Reeh, PW | 1 |
| Bradshaw, HB; Juknat, A; Kozela, E; Levy, R; Rimmerman, N; Vogel, Z | 1 |
| Fadda, P; Fratta, W; Gamaleddin, I; Goldberg, SR; Justinová, Z; Le Foll, B; Makriyannis, A; Mascia, P; Panlilio, LV; Scherma, M; Vadivel, SK; Zanettini, C | 1 |
| Shekhar, C | 1 |
| Ahmad, S; Groblewski, T; Ndong, C; O'Donnell, D | 1 |
| Cao, J; Cooper, TB; Finnell, RH; He, W; Hungund, BL; Hyson, RL; Psychoyos, D; Vinod, KY; Wlodarczyk, B; Xie, S | 1 |
| Cheng, K; Li, F; Lovinger, DM; Rice, KC; Wu, X; Xiong, W; Zhang, L | 1 |
| Rogers, TJ | 1 |
| Bacigaluppi, M; Bari, M; Brambilla, E; Butti, E; Cambiaghi, M; Cebrian Silla, A; Centonze, D; Comi, G; D'Adamo, P; De Ceglia, R; De Chiara, V; Garcia-Verdugo, JM; Leocani, L; Maccarrone, M; Martino, G; Musella, A; Muzio, L; Quattrini, A; Rossi, S; Teneud, L | 1 |
| Di Marzo, V; Skaper, SD | 1 |
| Busquets-Garcia, A; Maldonado, R; Ozaita, A; Puighermanal, E | 1 |
| Coppola, M; Mondola, R | 1 |
| Feliszek, M; Ilayan, E; Malinowska, B; Schlicker, E | 1 |
| Bart, Y; Eliasi, Y; Livneh, I; Monovich, E; Sagie, S | 1 |
| Abdelrahman, M; Gamage, TF; Greig, IR; Ignatowska-Jankowska, BM; Lichtman, AH; Pertwee, RG; Poklis, J; Ross, RA; Thakur, GA; Tichkule, R; Trembleau, L; Wiley, JL | 1 |
| Chavant, F; Duranti, A; Francheteau, M; Gennequin, B; Maccarrone, M; Makriyannis, A; Nader, J; Rapino, C; Solinas, M; Thiriet, N | 1 |
| Bindila, L; Jergas, B; Lutz, B; Schlicker, E; Schulte, K | 1 |
| Beardsley, PM; Burston, JJ; Lichtman, AH; Poklis, JL; Vann, RE; Walentiny, DM; Wiley, JL; Wright, MJ | 1 |
| Bagher, AM; Denovan-Wright, EM; Dupré, DJ; Kelly, ME; Laprairie, RB | 1 |
| Fišar, Z; Hroudová, J; Singh, N | 1 |
| De Angelis, V; de Groot, PG; Herczenik, E; Koekman, AC; Maas, C; Roest, M; Weeterings, C | 1 |
| Bari, M; Feole, M; Fezza, F; Florio, R; Maccarrone, M; Talamonti, E | 1 |
| Vann, RE; Walentiny, DM; Wiley, JL | 1 |
| Kokona, D; Thermos, K | 1 |
| Aguilar, DD; Giuffrida, A; Lodge, DJ | 1 |
| Lu, HC; Mackie, K | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Redhi, GH; Scherma, M; Schindler, CW; Vadivel, SK | 1 |
| Alapafuja, SO; Bergman, J; Kangas, BD; Leonard, MZ; Makriyannis, A; Nikas, SP; Shukla, VG | 1 |
| Frieling, H; Haase, A; Jahn, K; Martin, U; Naujock, M; Stanslowsky, N; Venneri, A; Wegner, F | 1 |
| Cravatt, BF; Lefever, TW; Lichtman, AH; Marusich, JA; Pulley, NS; Wiley, JL | 1 |
| Filipek, S; Jakowiecki, J | 1 |
| Bedse, G; Gaulden, AD; Hartley, ND; Kingsley, PJ; Marnett, LJ; Neale, E; Patel, S; Patrick, TA; Plath, N; Uddin, MJ | 1 |
| Arnold, WR; Das, A; Weigle, AT | 1 |
| Cuccurazzu, B; Grilli, M; Nazzaro, C; Parolaro, D; Prini, P; Rubino, T; Tonini, R; Trusel, M; Zamberletti, E | 1 |
| Chanda, D; Glatz, JFC; Neumann, D | 1 |
| Almada, M; Braga, J; Correia-da-Silva, G; Cunha, SC; Fonseca, BM; Gonçalves, D; Maia, J; Midão, L; Teixeira, N | 1 |
| Aria, F; Bonini, SA; Gianoncelli, A; Kumar, A; Maccarinelli, G; Mastinu, A; Memo, M; Premoli, M | 1 |
| Papadogkonaki, S; Theodorakis, Κ; Thermos, K | 1 |
| Nguyen, T | 1 |
| Kogan, NM; Mechoulam, R; Pacher, P | 1 |
| Giuffrida, A; Martinez, AA; Seillier, A | 1 |
| Molla, HM; Tseng, KY | 1 |
| Chapman, KD; Kilaru, A | 1 |
| Braga, J; Correia-da-Silva, G; Cunha, SC; Fonseca, BM; Gonçalves, D; Maia, J; Teixeira, N | 1 |
| Avilia, G; Bifulco, M; Coppola, L; Laezza, C; Navarra, G; Pagano, C; Savarese, B | 1 |
| Baio, G; Curran, HV; Freeman, TP; Hindocha, C; Hua, DY; Lees, R; Mofeez, A; Morgan, CJ; Shaban, N | 1 |
| Di Marzo, V; Gertsch, J; Grether, U; Howlett, AC; Hua, T; Maccarrone, M; Makriyannis, A; Piomelli, D; Ueda, N; van der Stelt, M | 1 |
34 review(s) available for dronabinol and anandamide
| Article | Year |
|---|---|
The endocannabinoid system: drug targets, lead compounds, and potential therapeutic applications.
Topics: Amides; Amidohydrolases; Amines; Animals; Arachidonic Acids; Binding Sites; Cannabinoid Receptor Modulators; Drug Design; Endocannabinoids; Esters; Ethers; Glycerides; Humans; Ligands; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Receptors, Cannabinoid | 2005 |
Sensing with TRP channels.
Topics: Animals; Humans; Ligands; Models, Biological; Phylogeny; Temperature; Transient Receptor Potential Channels | 2005 |
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.
Topics: Animals; Drug Design; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Substrate Specificity | 2013 |
Relationships between eicosanoids and cannabinoids. Are eicosanoids cannabimimetic agents?.
Topics: Adenylyl Cyclases; Animals; Arachidonic Acid; Arachidonic Acids; Cannabinoids; Dronabinol; Eicosanoids; Endocannabinoids; Polyunsaturated Alkamides; Psychotropic Drugs; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1995 |
Cannabinoid receptors and their endogenous agonist, anandamide.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cell Membrane; Dronabinol; Endocannabinoids; GTP-Binding Proteins; Humans; Models, Neurological; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Swine | 1998 |
Endocannabinoids.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cannabis; Dronabinol; Endocannabinoids; Glycerides; Humans; Mice; Polyunsaturated Alkamides; Signal Transduction; Structure-Activity Relationship | 1998 |
A hydrolase enzyme inactivating endogenous ligands for cannabinoid receptors.
Topics: Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; COS Cells; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Esterases; Ethanolamine; Fatty Acids; Hydrolysis; Intestine, Small; Ligands; Liver; Nerve Tissue Proteins; Organ Specificity; Organophosphonates; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Drug; Recombinant Fusion Proteins; Swine | 1998 |
Recent progress in the neurotoxicology of natural drugs associated with dependence or addiction, their endogenous agonists and receptors.
Topics: Acetylcholine; Arachidonic Acids; Brain Chemistry; Cannabis; Dronabinol; Endocannabinoids; Endorphins; Humans; Marijuana Abuse; Morphine; Morphine Dependence; Nicotine; Opium; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Receptors, Nicotinic; Receptors, Opioid; Tobacco Use Disorder | 1999 |
From gan-zi-gun-nu to anandamide and 2-arachidonoylglycerol: the ongoing story of cannabis.
Topics: Animals; Arachidonic Acids; Cannabis; Clinical Trials as Topic; Dronabinol; Endocannabinoids; Glycerides; Humans; Polyunsaturated Alkamides | 1999 |
Cannabimimetic fatty acid derivatives: the anandamide family and other endocannabinoids.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Endocannabinoids; Fatty Acids; Hallucinogens; Humans; Polyunsaturated Alkamides | 1999 |
Endocannabinoids and vascular function.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Endothelium, Vascular; Glycerides; Humans; Muscle, Smooth, Vascular; Neurons, Afferent; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 2000 |
The cannabinoid system and cytokine network.
Topics: Animals; Anti-Inflammatory Agents; Arachidonic Acids; Cannabinoids; Cytokines; Dronabinol; Endocannabinoids; Humans; Marijuana Smoking; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Tumor Necrosis Factor-alpha | 2000 |
[Cannabinoids, cannabinoid receptor and immune response].
Topics: Adjuvants, Immunologic; Animals; Antibody Formation; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Humans; Immunity, Cellular; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 2000 |
[A novel analgesics made from Cannabis].
Topics: Analgesics; Arachidonic Acids; Cannabidiol; Cannabinoids; Cannabis; Dronabinol; Drug Combinations; Drugs, Investigational; Endocannabinoids; Europe; Humans; Multiple Sclerosis; Pain; Plant Extracts; Polyunsaturated Alkamides | 2004 |
Cannabinoids in bipolar affective disorder: a review and discussion of their therapeutic potential.
Topics: Arachidonic Acids; Bipolar Disorder; Cannabidiol; Cannabinoids; Dronabinol; Endocannabinoids; Humans; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2005 |
New insights into endocannabinoid degradation and its therapeutic potential.
Topics: Arachidonic Acid; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabis; Cell Membrane; Chemistry, Pharmaceutical; Dronabinol; Endocannabinoids; Glycerides; Humans; Lipoprotein Lipase; Monoacylglycerol Lipases; Neoplasms; Nervous System Diseases; Phosphatidylethanolamines; Phospholipase D; Polyunsaturated Alkamides | 2006 |
The endocannabinoid system: a new target for the regulation of energy balance and metabolism.
Topics: Adipocytes; Adiponectin; Animals; Appetite Regulation; Arachidonic Acids; Cannabinoid Receptor Modulators; Carbohydrate Metabolism; Diabetes Mellitus, Type 2; Dronabinol; Eating; Endocannabinoids; Energy Metabolism; Humans; Lipid Metabolism; Obesity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Randomized Controlled Trials as Topic; Receptor, Cannabinoid, CB1; Rimonabant | 2007 |
Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Endocannabinoids; Glycerides; Humans; Marijuana Abuse; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2008 |
Targeting fatty acid amide hydrolase (FAAH) to treat pain and inflammation.
Topics: Amidohydrolases; Analgesics; Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acids; Disease Models, Animal; Dronabinol; Drug Delivery Systems; Drug Evaluation, Preclinical; Endocannabinoids; Glycerides; Humans; Inflammation; Mice; Mice, Knockout; Pain; Peroxisome Proliferator-Activated Receptors; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Opioid; TRPV Cation Channels | 2009 |
[Cannabinoids in the control of pain].
Topics: Amino Acid Sequence; Analgesics, Non-Narcotic; Anti-Inflammatory Agents, Non-Steroidal; Antiemetics; Arachidonic Acids; Cachexia; Cannabinoids; Cannabis; Dronabinol; Endocannabinoids; Humans; Molecular Sequence Data; Nausea; Pain; Phytotherapy; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2008 |
Behavioral pharmacology of cannabinoids with a focus on preclinical models for studying reinforcing and dependence-producing properties.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Conditioning, Classical; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Humans; Macaca mulatta; Marijuana Abuse; Mice; Motivation; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Reward; Self Administration; Substance Withdrawal Syndrome; Synaptic Transmission | 2008 |
Cannabinoids and the gut: new developments and emerging concepts.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cannabis; Dronabinol; Drug Evaluation, Preclinical; Drug Tolerance; Endocannabinoids; Gastrointestinal Diseases; Gastrointestinal Tract; Genetic Variation; Humans; Models, Biological; Polyunsaturated Alkamides; Receptors, Cannabinoid | 2010 |
Cellular and intracellular mechanisms involved in the cognitive impairment of cannabinoids.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cognition; Cognition Disorders; Dronabinol; Endocannabinoids; Glycerides; Hippocampus; Humans; Memory; Neuronal Plasticity; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Synaptic Transmission; TOR Serine-Threonine Kinases | 2012 |
[Short-and long-term effects of cannabinoids on memory, cognition and mental illness].
Topics: Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Cognition; Dronabinol; Endocannabinoids; Humans; Memory; Mental Disorders; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Time Factors | 2013 |
Endocannabinoids, related compounds and their metabolic routes.
Topics: Animals; Arachidonic Acids; Dronabinol; Endocannabinoids; Ethanolamines; Fatty Acids; Glycerides; Humans; Polyunsaturated Alkamides | 2014 |
An Introduction to the Endogenous Cannabinoid System.
Topics: Arachidonic Acids; Cannabinoid Receptor Agonists; Dronabinol; Endocannabinoids; Glycerides; Humans; Neuronal Plasticity; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Schizophrenia | 2016 |
The endocannabinoid system: Overview of an emerging multi-faceted therapeutic target.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Autocrine Communication; Cells; Dronabinol; Endocannabinoids; Glycerides; Humans; Mice; Molecular Targeted Therapy; Paracrine Communication; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Swine | 2019 |
Cannabimimetic plants: are they new cannabinoidergic modulators?
Topics: Animals; Arachidonic Acids; Biological Evolution; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Cannabis; Dronabinol; Endocannabinoids; Fruit; Humans; Phytochemicals; Plants; Polyunsaturated Alkamides; Receptors, Cannabinoid | 2019 |
Beyond THC and Endocannabinoids.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Dronabinol; Endocannabinoids; Glycerides; Humans; Polyunsaturated Alkamides | 2020 |
Neural substrates underlying the negative impact of cannabinoid exposure during adolescence.
Topics: Adolescent; Animals; Arachidonic Acids; Attention; Cognition; Dronabinol; Endocannabinoids; Executive Function; gamma-Aminobutyric Acid; Glycerides; Humans; Polyunsaturated Alkamides; Prefrontal Cortex; Receptor, Cannabinoid, CB1; Risk-Taking | 2020 |
The endocannabinoid system.
Topics: Animals; Arachidonic Acids; Cannabis; Central Nervous System; Dronabinol; Endocannabinoids; Glycerides; Humans; Ligands; Plant Extracts; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Signal Transduction | 2020 |
A Delightful Trip Along the Pathway of Cannabinoid and Endocannabinoid Chemistry and Pharmacology.
Topics: Cannabinoids; Child; Dronabinol; Endocannabinoids; Humans; Polyunsaturated Alkamides | 2023 |
Cannabinoids in the Modulation of Oxidative Signaling.
Topics: Antioxidants; Cannabidiol; Cannabinoids; Cannabis; Dronabinol; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species | 2023 |
Goods and Bads of the Endocannabinoid System as a Therapeutic Target: Lessons Learned after 30 Years.
Topics: Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoids; Cannabis; Carrier Proteins; Child; Dronabinol; Endocannabinoids; Hallucinogens; Humans | 2023 |
2 trial(s) available for dronabinol and anandamide
| Article | Year |
|---|---|
Lack of effect of cannabis-based treatment on clinical and laboratory measures in multiple sclerosis.
Topics: Adult; Arachidonic Acids; Cannabidiol; Cannabinoids; Dronabinol; Drug Combinations; Endocannabinoids; Female; Humans; Lymphocytes; Male; Middle Aged; Multiple Sclerosis; Muscle Spasticity; Pain; Plant Extracts; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reflex, Stretch; Treatment Outcome; Young Adult | 2009 |
Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder.
Topics: Cannabidiol; Cannabis; Double-Blind Method; Dronabinol; Endocannabinoids; Hallucinogens; Humans; Marijuana Abuse | 2023 |
193 other study(ies) available for dronabinol and anandamide
| Article | Year |
|---|---|
Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Amidohydrolases; Animals; Arachidonic Acids; Base Sequence; Binding, Competitive; Calcium; Calcium Channel Blockers; Cannabinoids; CHO Cells; Cricetinae; Endocannabinoids; Enzyme Activation; Humans; Intracellular Fluid; Ion Channels; Kinetics; Mice; Molecular Sequence Data; Phospholipases; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection | 1995 |
Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands.
Topics: Animals; Binding, Competitive; Brain; Cannabinoids; Cell Membrane; Cells, Cultured; CHO Cells; Cricetinae; Cyclohexanols; Guanine Nucleotides; Humans; Ligands; Rats; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Recombinant Proteins; Sodium; Structure-Activity Relationship; Transfection | 1996 |
Potent anandamide analogs: the effect of changing the length and branching of the end pentyl chain.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoids; Endocannabinoids; Magnetic Resonance Spectroscopy; Mass Spectrometry; Mice; Molecular Structure; Polyunsaturated Alkamides; Radioligand Assay; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 1997 |
A 3D-QSAR study on the structural requirements for binding to CB(1) and CB(2) cannabinoid receptors.
Topics: Arachidonic Acids; Cannabinoids; Drug Design; Endocannabinoids; Indoles; Ligands; Models, Biological; Models, Molecular; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2000 |
3D-QSAR studies on cannabinoid CB1 receptor agonists: G-protein activation as biological data.
Topics: Animals; Cannabinoid Receptor Modulators; Cerebellum; GTP-Binding Proteins; In Vitro Techniques; Ligands; Male; Models, Molecular; Molecular Structure; Quantitative Structure-Activity Relationship; Radioligand Assay; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 | 2006 |
The orphan receptor GPR55 is a novel cannabinoid receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Binding Sites; Binding, Competitive; Cannabidiol; Cannabinoids; Cell Line; Cloning, Molecular; Cyclohexanols; Down-Regulation; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ligands; Mice; Molecular Sequence Data; Organ Specificity; Polymerase Chain Reaction; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; RNA, Messenger; Signal Transduction; Structure-Activity Relationship | 2007 |
Δ(9) -Tetrahydrocannabinol and N-arachidonyl glycine are full agonists at GPR18 receptors and induce migration in human endometrial HEC-1B cells.
Topics: Arachidonic Acids; Cell Line, Tumor; Cell Movement; Dronabinol; Endometrium; Female; Glycine; HEK293 Cells; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Receptors, G-Protein-Coupled; RNA, Messenger; Transfection | 2012 |
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties.
Topics: Humans; Ligands; Molecular Docking Simulation; Pyrazoles; Receptor, Cannabinoid, CB2; Structure-Activity Relationship | 2016 |
FABP1: A Novel Hepatic Endocannabinoid and Cannabinoid Binding Protein.
Topics: Animals; Endocannabinoids; Fatty Acid-Binding Proteins; Female; Fluorescent Dyes; Humans; Liver; Male; Mice; Mice, Inbred C57BL; Receptors, Cannabinoid | 2016 |
Pot, heroin unlock new areas for neuroscience.
Topics: Amides; Animals; Arachidonic Acids; Brain; Cannabinoids; Dronabinol; Endocannabinoids; Enkephalin, Leucine; Fatty Acids, Unsaturated; Heroin; Humans; Morphine; Polyunsaturated Alkamides; Receptors, Opioid; Structure-Activity Relationship; Tea | 1992 |
Anandamide decreases naloxone-precipitated withdrawal signs in mice chronically treated with morphine.
Topics: Animals; Arachidonic Acids; Body Weight; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Mice; Mice, Inbred Strains; Morphine; Naloxone; Polyunsaturated Alkamides; Substance Withdrawal Syndrome | 1995 |
The preimplantation mouse embryo is a target for cannabinoid ligand-receptor signaling.
Topics: Animals; Arachidonic Acids; Base Sequence; Binding Sites; Blastocyst; Cannabidiol; Cannabinoids; Colforsin; Cyclic AMP; Dronabinol; Endocannabinoids; Fallopian Tubes; Female; Hallucinogens; Mice; Molecular Sequence Data; Polyunsaturated Alkamides; Pregnancy; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Signal Transduction; Uterus | 1995 |
Changes in rat brain cannabinoid binding sites after acute or chronic exposure to their endogenous agonist, anandamide, or to delta 9-tetrahydrocannabinol.
Topics: Analgesics; Animals; Arachidonic Acids; Brain Chemistry; Calcium Channel Blockers; Cannabinoids; Cannabis; Cyclohexanols; Dronabinol; Endocannabinoids; In Vitro Techniques; Kinetics; Male; Membranes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 1995 |
Stimulation of anandamide biosynthesis in N-18TG2 neuroblastoma cells by delta 9-tetrahydrocannabinol (THC).
Topics: Arachidonic Acid; Arachidonic Acids; Chromatography, Thin Layer; Dronabinol; Endocannabinoids; Ethanolamine; Ethanolamines; Neuroblastoma; Polyunsaturated Alkamides; Tumor Cells, Cultured | 1995 |
Cannabinoid ligand-receptor signaling in the mouse uterus.
Topics: Animals; Arachidonic Acids; Autoradiography; Base Sequence; Blotting, Northern; Calcium Channel Blockers; Cannabidiol; Cannabinoids; Cannabis; Colforsin; Cyclic AMP; DNA Primers; Dronabinol; Endocannabinoids; Female; Gene Expression; GTP-Binding Proteins; Mice; Mice, Inbred Strains; Molecular Sequence Data; Pertussis Toxin; Polymerase Chain Reaction; Polyunsaturated Alkamides; Pregnancy; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Signal Transduction; Tritium; Uterus; Virulence Factors, Bordetella | 1995 |
The endogenous cannabinoid receptor ligand, anandamide, inhibits the motor behavior: role of nigrostriatal dopaminergic neurons.
Topics: Animals; Arachidonic Acids; Cannabinoids; Corpus Striatum; Dronabinol; Endocannabinoids; Male; Motor Activity; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Dopamine; Receptors, Drug; Substantia Nigra | 1995 |
Effects of anandamide (endogen cannabinoid) on anterior pituitary hormone secretion in adult ovariectomized rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Female; Follicle Stimulating Hormone; Luteinizing Hormone; Ovariectomy; Pituitary Gland, Anterior; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1995 |
Discriminative stimulus effects of anandamide in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1995 |
Characterization of anandamide- and fluoroanandamide-induced antinociception and cross-tolerance to delta 9-THC after intrathecal administration to mice: blockade of delta 9-THC-induced antinociception.
Topics: Analgesics; Animals; Arachidonic Acids; Binding Sites; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Tolerance; Endocannabinoids; Injections, Spinal; Mice; Narcotic Antagonists; Pertussis Toxin; Polyunsaturated Alkamides; Potassium Channel Blockers; Rats; Spinal Cord; Synaptosomes; Virulence Factors, Bordetella | 1995 |
Low doses of anandamides inhibit pharmacological effects of delta 9-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Female; GTP-Binding Proteins; Mice; Mice, Inbred ICR; Polyunsaturated Alkamides; Species Specificity; Tumor Cells, Cultured | 1995 |
The pharmacological activity of anandamide, a putative endogenous cannabinoid, in mice.
Topics: Analgesics; Animals; Arachidonic Acids; Binding, Competitive; Brain; Calcium Channel Blockers; Cyclohexanols; Dronabinol; Drug Administration Routes; Drug Interactions; Endocannabinoids; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Polyunsaturated Alkamides; Receptors, Purinergic P2; Tritium | 1994 |
Anandamide (arachidonylethanolamide), a brain cannabinoid receptor agonist, reduces sperm fertilizing capacity in sea urchins by inhibiting the acrosome reaction.
Topics: Acrosome; Animals; Arachidonic Acid; Arachidonic Acids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Fertilization; Ionomycin; Male; Nigericin; Ovum; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Sea Urchins; Spermatozoa | 1994 |
delta 9-Tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats.
Topics: Amides; Animals; Arachidonic Acids; Catalepsy; Dronabinol; Drug Synergism; Endocannabinoids; Fatty Acids, Unsaturated; Globus Pallidus; Injections, Intraventricular; Muscimol; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1993 |
Effect of the brain constituent anandamide, a cannabinoid receptor agonist, on the hypothalamo-pituitary-adrenal axis in the rat.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Amides; Animals; Arachidonic Acids; Brain Chemistry; Corticosterone; Corticotropin-Releasing Hormone; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Hypothalamus; Kinetics; Male; Median Eminence; Pituitary Gland; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Drug; Swine | 1994 |
Cross-tolerance between delta-9-tetrahydrocannabinol and the cannabimimetic agents, CP 55,940, WIN 55,212-2 and anandamide.
Topics: Amides; Animals; Arachidonic Acids; Benzoxazines; Body Temperature; Cannabinoids; Cyclohexanols; Dronabinol; Drug Tolerance; Electric Stimulation; Endocannabinoids; Fatty Acids, Unsaturated; Male; Mice; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Vas Deferens | 1993 |
Pharmacological activity of the cannabinoid receptor agonist, anandamide, a brain constituent.
Topics: Amides; Animals; Arachidonic Acids; Behavior, Animal; Body Temperature; Brain Chemistry; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Female; Injections, Intraperitoneal; Male; Mice; Mice, Inbred C57BL; Motor Activity; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Stimulation, Chemical | 1993 |
Pharmacology. Medical uses of marijuana?
Topics: Amides; Animals; Arachidonic Acids; Cannabis; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Humans; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1993 |
Structure-activity analysis of anandamide analogs: relationship to a cannabinoid pharmacophore.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Dronabinol; Endocannabinoids; Mice; Models, Molecular; Molecular Conformation; Polyunsaturated Alkamides; Structure-Activity Relationship | 1996 |
Anandamides: tolerance and cross-tolerance to delta 9-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Ethanolamines; Fatty Acids, Unsaturated; Female; Mice; Mice, Inbred C57BL; Mice, Inbred Strains; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Time Factors | 1995 |
Anandamide and delta 9-THC dilation of cerebral arterioles is blocked by indomethacin.
Topics: Administration, Topical; Animals; Arachidonic Acids; Arterioles; Cannabinoids; Cerebrovascular Circulation; Cyclooxygenase Inhibitors; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Indomethacin; Male; Polyunsaturated Alkamides; Rabbits; Vasodilation | 1995 |
Anandamide- and delta9-tetrahydrocannabinol-evoked arachidonic acid mobilization and blockade by SR141716A [N-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4 -methyl-1H-pyrazole-3-carboximide hydrochloride].
Topics: Amidohydrolases; Animals; Arachidonic Acid; Arachidonic Acids; Astrocytes; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant; Virulence Factors, Bordetella | 1996 |
Mechanism of the hypotensive action of anandamide in anesthetized rats.
Topics: Anesthesia; Animals; Arachidonic Acids; Blood Pressure; Cannabinoids; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Pressoreceptors; Rats; Rats, Sprague-Dawley; Sympathetic Nervous System | 1996 |
Ontogenetic development of the response to anandamide and delta 9-tetrahydrocannabinol in mice.
Topics: Aging; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Female; Male; Mice; Mice, Inbred C57BL; Motor Activity; Pain Measurement; Polyunsaturated Alkamides | 1996 |
Anandamide, an endogenous cannabinoid, inhibits Shaker-related voltage-gated K+ channels.
Topics: Animals; Arachidonic Acids; Brain; Cells, Cultured; Dronabinol; Endocannabinoids; Kv1.2 Potassium Channel; Patch-Clamp Techniques; Phospholipase D; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shaker Superfamily of Potassium Channels; Structure-Activity Relationship; Transfection | 1996 |
Time-course of the effects of anandamide, the putative endogenous cannabinoid receptor ligand, on extrapyramidal function.
Topics: Animals; Arachidonic Acids; Corpus Striatum; Dopamine; Dronabinol; Endocannabinoids; Ligands; Male; Motor Activity; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Stereotyped Behavior; Substantia Nigra; Time Factors | 1995 |
Todd's achievement.
Topics: Arachidonic Acids; Cannabinol; Dronabinol; Endocannabinoids; History, 20th Century; Polyunsaturated Alkamides | 1997 |
Receptor mediation in cannabinoid stimulated arachidonic acid mobilization and anandamide synthesis.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Blotting, Western; Cell Line; Dronabinol; Endocannabinoids; Humans; Mice; Oligonucleotides, Antisense; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Tumor Cells, Cultured | 1997 |
Nonclassical and endogenous cannabinoids: effects on the ordering of brain membranes.
Topics: Analgesics; Animals; Arachidonic Acid; Arachidonic Acids; Benzoxazines; Brain; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Male; Membrane Lipids; Morpholines; Naphthalenes; Phenanthridines; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship; Synaptic Membranes | 1997 |
Characterization of anandamide-induced tolerance: comparison to delta 9-THC-induced interactions with dynorphinergic systems.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Dynorphins; Endocannabinoids; Injections, Intraperitoneal; Injections, Spinal; Mice; Naltrexone; Narcotic Antagonists; Pain Measurement; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1997 |
Influence of fatty acid ethanolamides and delta9-tetrahydrocannabinol on cytokine and arachidonate release by mononuclear cells.
Topics: Amides; Arachidonic Acid; Arachidonic Acids; Cytokines; Dronabinol; Endocannabinoids; Ethanolamines; Humans; Leukocytes, Mononuclear; Palmitic Acids; Polyunsaturated Alkamides; Secretory Rate | 1997 |
Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Topics: Animals; Arachidonic Acids; Autoradiography; Dronabinol; Endocannabinoids; Gonadotropins, Pituitary; Hypothalamus; Male; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 1997 |
(R)-methanandamide, but not anandamide, substitutes for delta 9-THC in a drug-discrimination procedure.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Generalization, Stimulus; Hallucinogens; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1997 |
The effects of prenatally administered endogenous cannabinoid on rat offspring.
Topics: Age Factors; Animals; Arachidonic Acids; Body Weight; Cannabinoids; Dronabinol; Endocannabinoids; Female; Hypothalamus; Male; Maternal Exposure; Pituitary Gland; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Sex Factors | 1997 |
SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant | 1997 |
Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1997 |
Evaluation of cannabimimetic discriminative stimulus effects of anandamide and methylated fluoroanandamide in rhesus monkeys.
Topics: Analgesics; Animals; Arachidonic Acids; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Hallucinogens; Macaca mulatta; Male; Polyunsaturated Alkamides | 1997 |
Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission.
Topics: Animals; Arachidonic Acids; Brain; Calcium; Calcium Channel Blockers; Cannabinoids; Cerebellum; Cerebral Cortex; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Membrane Potentials; N-Methylaspartate; Neurons; Oocytes; Pertussis Toxin; Picrotoxin; Polyunsaturated Alkamides; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Receptors, N-Methyl-D-Aspartate; Synaptic Transmission; Virulence Factors, Bordetella; Wasp Venoms; Xenopus laevis | 1998 |
Identification and characterization of a novel synthetic cannabinoid CP 55,940 binder in rat brain cytosol.
Topics: Animals; Arachidonic Acids; Binding, Competitive; Cannabinoids; Cerebral Cortex; Cyclohexanols; Cytosol; Dithiothreitol; Dronabinol; Endocannabinoids; Kinetics; Male; Nucleotides; Organ Specificity; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Cytoplasmic and Nuclear; Receptors, Drug; Salts; Sulfhydryl Reagents; Temperature | 1998 |
Characterization of delta9-tetrahydrocannabinol and anandamide antinociception in nonarthritic and arthritic rats.
Topics: Analgesics; Animals; Arachidonic Acids; Arthritis, Experimental; Cannabinoids; Dronabinol; Endocannabinoids; Male; Opioid Peptides; Pain Threshold; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Effects of cannabinoids on preimplantation mouse embryo development and implantation are mediated by brain-type cannabinoid receptors.
Topics: Animals; Arachidonic Acids; Brain; Cannabinoids; Cytochrome P-450 Enzyme Inhibitors; Dronabinol; Embryo Implantation; Embryo, Mammalian; Embryonic and Fetal Development; Embryonic Development; Endocannabinoids; Enzyme Inhibitors; Female; Glycerides; Male; Mice; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Delta9-tetrahydrocannabinol, but not the endogenous cannabinoid receptor ligand anandamide, produces conditioned place avoidance.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Cannabinoids; Dronabinol; Endocannabinoids; Half-Life; Hallucinogens; Male; Motor Activity; Phenylmethylsulfonyl Fluoride; Polyunsaturated Alkamides; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug | 1998 |
Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension.
Topics: Animals; Arachidonic Acids; Blood Platelets; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Glycerides; Hypotension; Lipopolysaccharides; Macrophages; Male; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
A comparison of delta 9-THC and anandamide induced c-fos expression in the rat forebrain.
Topics: Animals; Arachidonic Acids; Body Temperature; Dronabinol; Endocannabinoids; Gene Expression; Male; Motor Activity; Neurons; Polyunsaturated Alkamides; Prosencephalon; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Tissue Distribution | 1998 |
Evaluation of cannabimimetic effects of structural analogs of anandamide in rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Discrimination, Psychological; Dronabinol; Endocannabinoids; Male; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 1998 |
Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcimycin; Cell Line; Dronabinol; Endocannabinoids; Immune System; Indomethacin; Ionophores; Lipopolysaccharides; Macrophages; Mice; Platelet Activating Factor; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 1998 |
Effects of SR 141716A after acute or chronic cannabinoid administration in dogs.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Cannabinoids; Dogs; Dronabinol; Endocannabinoids; Female; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Substance Withdrawal Syndrome; Time Factors | 1998 |
The actions of some cannabinoid receptor ligands in the rat isolated mesenteric artery.
Topics: Amides; Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Endothelium, Vascular; Ethanolamines; In Vitro Techniques; Ligands; Male; Mesenteric Arteries; Methoxamine; Morpholines; Muscle Contraction; Muscle, Smooth, Vascular; Naphthalenes; Palmitic Acids; Polyunsaturated Alkamides; Rats; Rats, Wistar | 1998 |
The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9-tetrahydrocannabinol or anandamide.
Topics: Animals; Arachidonic Acids; Discrimination Learning; Dronabinol; Endocannabinoids; Male; Memory Disorders; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 1998 |
Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: evidence for agonist-specific trafficking of intracellular responses.
Topics: Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Arachidonic Acids; Benzoxazines; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Cyclohexanols; Dronabinol; Endocannabinoids; Enzyme Activation; Humans; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction; Transfection | 1998 |
Evidence that the cannabinoid CB1 receptor is a 2-arachidonoylglycerol receptor. Structure-activity relationship of 2-arachidonoylglycerol, ether-linked analogues, and related compounds.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cell Line; Cyclohexanols; Dronabinol; Endocannabinoids; Models, Chemical; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Structure-Activity Relationship | 1999 |
Mesenteric vasodilation mediated by endothelial anandamide receptors.
Topics: Animals; Arachidonic Acid; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Endothelium, Vascular; Glycerides; Ligands; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Drug; Rimonabant; Vasoconstriction; Vasodilation | 1999 |
Inhibition of the production of endothelium-derived hyperpolarizing factor by cannabinoid receptor agonists.
Topics: Animals; Arachidonic Acids; Biological Factors; Calcium; Cells, Cultured; Cyclic AMP; Cytochrome P-450 Enzyme System; Dronabinol; Endocannabinoids; Female; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rabbits; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Swine; Vasoconstriction | 1999 |
Presynaptic cannabinoid and imidazoline receptors in the human heart and their potential relationship.
Topics: Adrenergic Uptake Inhibitors; Arachidonic Acids; Atrial Function; Corticosterone; Cyclohexanols; Desipramine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Electrophysiology; Endocannabinoids; Excitatory Amino Acid Agonists; Female; Guanidine; Humans; Imidazoles; Imidazoline Receptors; Ligands; Male; Norepinephrine; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Receptors, Presynaptic; Sympathetic Nervous System; Sympathomimetics | 1999 |
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Topics: Animals; Arachidonic Acids; Cannabidiol; Cannabinoids; Dronabinol; Endocannabinoids; Endothelium, Vascular; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation; Vasodilator Agents | 1999 |
Carrier-mediated uptake of the endogenous cannabinoid anandamide in RBL-2H3 cells.
Topics: Amidohydrolases; Arachidonic Acids; Biological Transport; Cannabinoids; Carrier Proteins; Cell Line; Dronabinol; Endocannabinoids; Mast Cells; Polyunsaturated Alkamides | 2000 |
Dynorphin B and spinal analgesia: induction of antinociception by the cannabinoids CP55,940, Delta(9)-THC and anandamide.
Topics: Analgesia; Analgesics; Analgesics, Non-Narcotic; Animals; Arachidonic Acids; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dronabinol; Dynorphins; Endocannabinoids; Endorphins; Male; Pain; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Spinal Cord | 2000 |
Pharmacological characterisation of cannabinoid CB(1) receptors in the rat and mouse.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoids; Cyclohexanols; Dronabinol; Endocannabinoids; Heart Atria; In Vitro Techniques; Male; Mesenteric Artery, Inferior; Mice; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sympathetic Nervous System; Synaptic Transmission; Vas Deferens; Vascular Resistance | 2000 |
Sex steroid influence on cannabinoid CB(1) receptor mRNA and endocannabinoid levels in the anterior pituitary gland.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Endocannabinoids; Estradiol; Female; Gene Expression; Glycerides; Gonadal Steroid Hormones; Hydroxytestosterones; Hypothalamus; Male; Menstrual Cycle; Orchiectomy; Ovariectomy; Pituitary Gland, Anterior; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger; Sex Factors | 2000 |
Enhancement of anandamide formation in the limbic forebrain and reduction of endocannabinoid contents in the striatum of delta9-tetrahydrocannabinol-tolerant rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoid Receptor Modulators; Cannabinoids; Down-Regulation; Dronabinol; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Limbic System; Male; Marijuana Abuse; Morpholines; Naphthalenes; Phosphatidylethanolamines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sulfur Radioisotopes; Tritium | 2000 |
The CB1 cannabinoid receptor is coupled to the activation of protein kinase B/Akt.
Topics: Adenylate Cyclase Toxin; Androstadienes; Arachidonic Acids; Astrocytoma; Calcium-Calmodulin-Dependent Protein Kinases; Cannabinoids; Dronabinol; Endocannabinoids; Enzyme Activation; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Heterotrimeric GTP-Binding Proteins; HL-60 Cells; Humans; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Polyunsaturated Alkamides; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Cannabinoid; Receptors, Drug; Tumor Cells, Cultured; Virulence Factors, Bordetella; Wortmannin | 2000 |
Changes in rat brain energetic metabolism after exposure to anandamide or Delta(9)-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoids; Dronabinol; Endocannabinoids; Energy Metabolism; Lipid Peroxidation; Lipid Peroxides; Male; Mitochondria; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2000 |
CB1 cannabinoid receptor-mediated cell migration.
Topics: 8-Bromo Cyclic Adenosine Monophosphate; Adenylate Cyclase Toxin; Arachidonic Acids; Benzoxazines; Cell Movement; Cells, Cultured; Dronabinol; Endocannabinoids; Humans; Mitogen-Activated Protein Kinases; Morpholines; Naphthalenes; Pertussis Toxin; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Virulence Factors, Bordetella | 2000 |
Levels, metabolism, and pharmacological activity of anandamide in CB(1) cannabinoid receptor knockout mice: evidence for non-CB(1), non-CB(2) receptor-mediated actions of anandamide in mouse brain.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Cell Membrane; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Female; Glycerides; Guanosine 5'-O-(3-Thiotriphosphate); Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Organ Specificity; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 2000 |
Cannabinoid antagonists: a treatment in search of an illness.
Topics: Adjuvants, Immunologic; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Humans; Marijuana Abuse; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Cannabinoids inhibit the formation of new synapses between hippocampal neurons in culture.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cells, Cultured; Colforsin; Cyclic AMP; Dronabinol; Endocannabinoids; Fluorescent Dyes; Hippocampus; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Piperidines; Polyunsaturated Alkamides; Presynaptic Terminals; Pyrazoles; Pyridinium Compounds; Quaternary Ammonium Compounds; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Synapses | 2001 |
Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro.
Topics: Amides; Animals; Arachidonic Acids; Benzalkonium Compounds; Benzoxazines; Cannabinoid Receptor Modulators; Cannabinoids; Cells, Cultured; Dronabinol; Endocannabinoids; Ethanolamines; Histamine Release; Male; Mast Cells; Morpholines; Naphthalenes; p-Methoxy-N-methylphenethylamine; Palmitic Acids; Peritoneum; Polyunsaturated Alkamides; Rats; Rats, Wistar | 2001 |
Critical role of the endogenous cannabinoid system in mouse pup suckling and growth.
Topics: Animals; Animals, Newborn; Appetite; Arachidonic Acids; Cannabinoid Receptor Modulators; Chromatography, High Pressure Liquid; Dronabinol; Endocannabinoids; Growth; Mice; Milk; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2001 |
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.
Topics: Animals; Arachidonic Acids; Blood Pressure; Brain; Cannabinoids; Coronary Circulation; Coronary Vessels; Dronabinol; Endocannabinoids; Heart Rate; Hemodynamics; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vascular Resistance; Vasodilation | 2001 |
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant | 2001 |
2-Arachidonoylglycerol and anandamide oppositely modulate norepinephrine release from the rat heart sympathetic nerves.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Dronabinol; Endocannabinoids; Glycerides; Male; Myocardium; Neurotransmitter Agents; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Sympathetic Nervous System | 2001 |
Fatty acid amide hydrolase inhibitors and the marijuana debate.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Dronabinol; Endocannabinoids; Humans; Mice; Pain; Polyunsaturated Alkamides | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
Assessment of structural commonality between tetrahydrocannabinol and anandamide.
Topics: Animals; Antipsychotic Agents; Arachidonic Acids; Calcium Channel Blockers; Cells, Cultured; Dronabinol; Endocannabinoids; Humans; Male; Mice; Mice, Inbred ICR; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Structure-Activity Relationship | 2002 |
Cannabinoids and brain injury: therapeutic implications.
Topics: Animals; Arachidonic Acids; Brain; Brain Injuries; Cannabinoid Receptor Modulators; Cannabinoids; Clinical Trials, Phase III as Topic; Dronabinol; Endocannabinoids; Glycerides; Humans; Neuroprotective Agents; Pain; Polyunsaturated Alkamides; Rats | 2002 |
Role of CB1 and CB2 receptors in the inhibitory effects of cannabinoids on lipopolysaccharide-induced nitric oxide release in astrocyte cultures.
Topics: Analgesics; Animals; Arachidonic Acids; Astrocytes; Calcium Channel Blockers; Camphanes; Cannabinoids; Cells, Cultured; Cyclohexanols; Dronabinol; Endocannabinoids; Gene Expression; Lipopolysaccharides; Mice; Mice, Inbred Strains; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Postsynaptic endocannabinoid release is critical to long-term depression in the striatum.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Corpus Striatum; Dronabinol; Electric Stimulation; Endocannabinoids; Excitatory Postsynaptic Potentials; In Vitro Techniques; Mice; Mice, Knockout; Neural Inhibition; Neuronal Plasticity; Neurons; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug; Synapses | 2002 |
Observational analysis of feeding induced by Delta9-THC and anandamide.
Topics: Animals; Appetite Stimulants; Arachidonic Acids; Cannabinoid Receptor Modulators; Dronabinol; Eating; Endocannabinoids; Feeding Behavior; Male; Motivation; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Drug; Videotape Recording | 2002 |
Experimental parkinsonism alters endocannabinoid degradation: implications for striatal glutamatergic transmission.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Carrier Proteins; Corpus Striatum; Disease Models, Animal; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glutamic Acid; Glycerides; Hydrolysis; In Vitro Techniques; Membrane Potentials; Neurons; Oxidopamine; Parkinsonian Disorders; Patch-Clamp Techniques; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Synaptic Transmission | 2002 |
Decrease in efficacy and potency of nonsteroidal anti-inflammatory drugs by chronic delta(9)-tetrahydrocannabinol administration.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Arachidonic Acid; Arachidonic Acids; Aspirin; Camphanes; Diclofenac; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Indomethacin; Kinetics; Male; Mice; Mice, Inbred ICR; Pain; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug | 2002 |
Anandamide induces cough in conscious guinea-pigs through VR1 receptors.
Topics: Aerosols; Animals; Arachidonic Acids; Calcium; Camphanes; Capsaicin; Cells, Cultured; Consciousness; Cough; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Guinea Pigs; Male; Nodose Ganglion; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant | 2002 |
Cannabinoid influences on palatability: microstructural analysis of sucrose drinking after delta(9)-tetrahydrocannabinol, anandamide, 2-arachidonoyl glycerol and SR141716.
Topics: Animals; Appetite Stimulants; Arachidonic Acids; Behavior, Animal; Cannabinoid Receptor Modulators; Cannabinoids; Dose-Response Relationship, Drug; Drinking Behavior; Dronabinol; Endocannabinoids; Glycerides; Male; Neurotransmitter Agents; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Sucrose; Time Factors | 2003 |
Effects of cannabinoid receptor agonists on immunologically induced histamine release from rat peritoneal mast cells.
Topics: Adjuvants, Immunologic; Amides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antibodies, Anti-Idiotypic; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Endocannabinoids; Ethanolamines; Histamine Release; Immunoglobulin E; Male; Mast Cells; Morpholines; Naphthalenes; Ovalbumin; Palmitic Acids; Peritoneal Cavity; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug | 2003 |
Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response.
Topics: Arachidonic Acids; Calcium; Calcium Channel Blockers; Cannabinoids; Capsaicin; Cyclic AMP; Dronabinol; Endocannabinoids; Humans; Polyunsaturated Alkamides; Receptors, Cannabinoid; Receptors, Drug | 2003 |
Neuroscience. Stout guards of the central nervous system.
Topics: Animals; Anticonvulsants; Arachidonic Acids; Brain; Brain Diseases; Cannabidiol; Cannabinoid Receptor Modulators; Cannabinoids; Convulsants; Dronabinol; Endocannabinoids; Epilepsy; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; gamma-Aminobutyric Acid; Glutamic Acid; Glycerides; Humans; Kainic Acid; Mice; Neurons; Neuroprotective Agents; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Receptors, Drug; Signal Transduction | 2003 |
Cannabinoids and the human uterus during pregnancy.
Topics: Adult; Arachidonic Acids; Camphanes; Dronabinol; Endocannabinoids; Female; Humans; In Vitro Techniques; Myometrium; Piperidines; Polyunsaturated Alkamides; Pregnancy; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Rimonabant; RNA, Messenger; Uterine Contraction; Uterus | 2004 |
Cannabinoid CB1 receptor-mediated modulation of evoked dopamine release and of adenylyl cyclase activity in the human neocortex.
Topics: Adenylyl Cyclases; Amygdala; Animals; Arachidonic Acids; Benzoxazines; Binding Sites; Colforsin; Cyclic AMP; Cyclohexanols; Dopamine; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Humans; Ligands; Male; Morpholines; Naphthalenes; Neocortex; Piperidines; Polyunsaturated Alkamides; Potassium; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Synaptosomes; Tetrodotoxin; Tritium | 2004 |
Behavioral and molecular changes elicited by acute administration of SR141716 to Delta9-tetrahydrocannabinol-tolerant rats: an experimental model of cannabinoid abstinence.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Brain; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Corticosterone; Dronabinol; Drug Administration Schedule; Drug Tolerance; Endocannabinoids; Glycerides; Male; Paraventricular Hypothalamic Nucleus; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Corticotropin-Releasing Hormone; Rimonabant; RNA, Messenger; Substance Withdrawal Syndrome | 2004 |
A critical interaction between dopamine D2 receptors and endocannabinoids mediates the effects of cocaine on striatal gabaergic Transmission.
Topics: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; Amidohydrolases; Animals; Arachidonic Acids; Cerebral Cortex; Cocaine; Cyclohexanols; Dopamine Agonists; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Excitatory Postsynaptic Potentials; gamma-Aminobutyric Acid; In Vitro Techniques; Male; Neostriatum; Patch-Clamp Techniques; Polyunsaturated Alkamides; Quinpirole; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Receptors, Dopamine D2; Synaptic Transmission; Synaptosomes | 2004 |
Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide.
Topics: Adult; Arachidonic Acids; Cyclohexanols; Dronabinol; Endocannabinoids; Female; Humans; Male; Neutrophils; Polyunsaturated Alkamides; Receptors, Cannabinoid; Superoxides | 2004 |
Activation through cannabinoid receptors 1 and 2 on dendritic cells triggers NF-kappaB-dependent apoptosis: novel role for endogenous and exogenous cannabinoids in immunoregulation.
Topics: Animals; Apoptosis; Arachidonic Acids; BH3 Interacting Domain Death Agonist Protein; Blotting, Western; Bone Marrow; Cannabinoids; Carrier Proteins; Dendritic Cells; Dronabinol; Endocannabinoids; Female; Mice; Mice, Knockout; NF-kappa B; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
A comparison of the discriminative stimulus effects of delta(9)-tetrahydrocannabinol and O-1812, a potent and metabolically stable anandamide analog, in rats.
Topics: Analgesics, Non-Narcotic; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Drug; Rimonabant | 2004 |
Endocannabinoids acting at cannabinoid-1 receptors regulate cardiovascular function in hypertension.
Topics: Amidohydrolases; Angiotensin II; Animals; Arachidonic Acids; Benzamides; Benzyl Compounds; Blood Pressure; Camphanes; Carbamates; Dronabinol; Endocannabinoids; Endothelium, Vascular; Hypertension; Male; Models, Cardiovascular; Myocardial Contraction; Myocardium; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Inbred Dahl; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Up-Regulation; Vascular Resistance; Vasodilation; Ventricular Function, Left | 2004 |
Vascular effects of delta 9-tetrahydrocannabinol (THC), anandamide and N-arachidonoyldopamine (NADA) in the rat isolated aorta.
Topics: Animals; Aorta; Arachidonic Acids; Cannabinoids; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; In Vitro Techniques; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Vasomotor System | 2005 |
Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids.
Topics: Animals; Arachidonic Acids; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Cells, Cultured; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Ion Channels; Polyunsaturated Alkamides; Rats; Recombinant Proteins; Species Specificity; Temperature; TRPV Cation Channels | 2005 |
Task specificity of cross-tolerance between Delta9-tetrahydrocannabinol and anandamide analogs in mice.
Topics: Animals; Arachidonic Acids; Body Temperature; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Male; Mice; Mice, Inbred ICR; Polyunsaturated Alkamides; Psychomotor Performance; Random Allocation; Rectum | 2005 |
Hemodynamic profile, responsiveness to anandamide, and baroreflex sensitivity of mice lacking fatty acid amide hydrolase.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Baroreflex; Blood Pressure; Cannabinoid Receptor Modulators; Cannabinoids; Cardiotonic Agents; Dronabinol; Endocannabinoids; Heart; Hemodynamics; Mice; Mice, Knockout; Myocardium; Phenylephrine; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2005 |
The effects of Delta9-tetrahydrocannabinol in rat mesenteric vasculature, and its interactions with the endocannabinoid anandamide.
Topics: Animals; Apamin; Arachidonic Acids; Azepines; Barium Compounds; Biological Factors; Calcium; Cannabinoid Receptor Modulators; Capsaicin; Charybdotoxin; Chlorides; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Endothelium, Vascular; Female; In Vitro Techniques; Indoles; Male; Mesenteric Arteries; Pertussis Toxin; Piperidines; Polyunsaturated Alkamides; Potassium Channel Blockers; Potassium Channels; Pyrazoles; Rats; Rats, Wistar; Rimonabant; Vasodilation; Verapamil | 2005 |
Cocaine- and amphetamine-related transcript is involved in the orexigenic effect of endogenous anandamide.
Topics: Animals; Appetite; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dronabinol; Eating; Endocannabinoids; Food Deprivation; Immunohistochemistry; Mice; Mice, Knockout; Nerve Endings; Nerve Fibers; Nerve Tissue Proteins; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2005 |
Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones.
Topics: Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoid Receptor Modulators; Cells, Cultured; Dronabinol; Endocannabinoids; Excitatory Postsynaptic Potentials; Glutamic Acid; Glycerides; Hippocampus; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Neuronal Plasticity; Neurons; Nitric Oxide; Patch-Clamp Techniques; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2005 |
Evidence that the plant cannabinoid Delta9-tetrahydrocannabivarin is a cannabinoid CB1 and CB2 receptor antagonist.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cannabis; CHO Cells; Clonidine; Cricetinae; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); In Vitro Techniques; Male; Mice; Morpholines; Muscle Contraction; Naphthalenes; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Vas Deferens | 2005 |
Cannabinoids promote embryonic and adult hippocampus neurogenesis and produce anxiolytic- and antidepressant-like effects.
Topics: Animals; Anti-Anxiety Agents; Antidepressive Agents; Arachidonic Acids; Cannabinoids; Cell Proliferation; Cells, Cultured; Dronabinol; Endocannabinoids; Hippocampus; Male; Neurons; Polyunsaturated Alkamides; Rats; Rats, Inbred F344; Rats, Long-Evans; Rats, Wistar; Receptor, Cannabinoid, CB1; Signal Transduction; Stem Cells | 2005 |
Delta9-tetrahydrocannabinol and endogenous cannabinoid anandamide directly potentiate the function of glycine receptors.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dronabinol; Endocannabinoids; Glycine; Humans; Mutation; Neurons; Oocytes; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1; Receptors, Glycine; Ventral Tegmental Area; Xenopus laevis | 2006 |
Antidepressant-like activity and modulation of brain monoaminergic transmission by blockade of anandamide hydrolysis.
Topics: Animals; Antidepressive Agents; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Agonists; Carbamates; Dronabinol; Endocannabinoids; Hydrolysis; Male; Mice; Mice, Inbred C57BL; Neurons; Norepinephrine; Polyunsaturated Alkamides; Rats; Receptors, Cannabinoid; Serotonin | 2005 |
The cannabinoid agonist WIN 55,212-2 inhibits TNF-alpha-induced neutrophil transmigration across ECV304 cells.
Topics: Analysis of Variance; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cell Line; Cell Movement; Chemotaxis; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Flow Cytometry; Humans; Indoles; Interleukin-8; L-Lactate Dehydrogenase; Morpholines; Naphthalenes; Neutrophils; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Interleukin-8A; Receptors, Interleukin-8B; Thapsigargin; Tumor Necrosis Factor-alpha | 2006 |
Cannabinoids and neuronal damage: differential effects of THC, AEA and 2-AG on activated microglial cells and degenerating neurons in excitotoxically lesioned rat organotypic hippocampal slice cultures.
Topics: Animals; Animals, Newborn; Arachidonic Acids; Brain; Brain Damage, Chronic; Cannabinoids; Cell Count; Disease Models, Animal; Dronabinol; Endocannabinoids; Gliosis; Glycerides; Microglia; N-Methylaspartate; Nerve Degeneration; Neurons; Neuroprotective Agents; Neurotoxins; Organ Culture Techniques; Plant Lectins; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptor, Cannabinoid, CB2; Treatment Outcome | 2007 |
Inhibition of fatty-acid amide hydrolase accelerates acquisition and extinction rates in a spatial memory task.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Brain Chemistry; Cannabinoid Receptor Modulators; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Extinction, Psychological; Female; Lipid Metabolism; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Knockout; Obsessive-Compulsive Disorder; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Pyridines; Receptor, Cannabinoid, CB1; Rimonabant; Stress Disorders, Post-Traumatic | 2007 |
5-HT1A receptors are involved in the anxiolytic effect of Delta9-tetrahydrocannabinol and AM 404, the anandamide transport inhibitor, in Sprague-Dawley rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anxiety; Arachidonic Acids; Dronabinol; Endocannabinoids; Exploratory Behavior; Male; Piperazines; Polyunsaturated Alkamides; Psychotropic Drugs; Pyridines; Rats; Rats, Sprague-Dawley; Serotonin 5-HT1 Receptor Agonists; Serotonin 5-HT1 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists | 2007 |
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport, Active; Brain Chemistry; Carbamates; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Furans; Hallucinogens; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; TRPV Cation Channels | 2007 |
Nicotinic facilitation of delta9-tetrahydrocannabinol discrimination involves endogenous anandamide.
Topics: Animals; Arachidonic Acids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Synergism; Endocannabinoids; Enzyme Inhibitors; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Mecamylamine; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Pilocarpine; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reaction Time; Receptor, Cannabinoid, CB1; Receptors, Muscarinic; Receptors, Nicotinic; Reinforcement, Psychology; Scopolamine | 2007 |
Interactions of cannabidiol with endocannabinoid signalling in hippocampal tissue.
Topics: Animals; Arachidonic Acids; Benzamides; Calcium; Cannabidiol; Cannabinoid Receptor Modulators; Carbamates; Cells, Cultured; Dronabinol; Endocannabinoids; Estrenes; Glutamic Acid; Glycerides; Hippocampus; Humans; Morpholines; Pertussis Toxin; Phosphodiesterase Inhibitors; Polyunsaturated Alkamides; Pyrazoles; Pyrrolidinones; Rats; Receptor, Cannabinoid, CB1; Signal Transduction | 2007 |
Effect of cannabinoids on platelet serotonin uptake.
Topics: Adult; Arachidonic Acids; Benzoxazines; Blood Platelets; Cannabinoids; Cell Membrane; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Female; Humans; Imipramine; In Vitro Techniques; Male; Marijuana Smoking; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Serotonin; Serotonin Plasma Membrane Transport Proteins; Sex Characteristics; Viscosity | 2007 |
Attenuation of allergic contact dermatitis through the endocannabinoid system.
Topics: Animals; Arachidonic Acids; Camphanes; Cannabinoid Receptor Modulators; Cannabinoids; Chemokines; Dermatitis, Allergic Contact; Dinitrofluorobenzene; Disease Models, Animal; Down-Regulation; Dronabinol; Endocannabinoids; Female; Glycerides; Mice; Mice, Inbred C57BL; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Skin; Up-Regulation | 2007 |
Effects of anandamide and noxious heat on intracellular calcium concentration in nociceptive drg neurons of rats.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Calcium; Calcium Channel Blockers; Capsaicin; Chelating Agents; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Egtazic Acid; Endocannabinoids; Extracellular Fluid; Ganglia, Spinal; Hot Temperature; Neurons; Physical Stimulation; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; TRPV Cation Channels | 2007 |
The endocannabinoid system is dysregulated in multiple sclerosis and in experimental autoimmune encephalomyelitis.
Topics: Acute Disease; Adult; Animals; Arachidonic Acids; Brain; Cannabinoid Receptor Modulators; Corpus Striatum; Disease Models, Animal; Dronabinol; Electrophysiology; Encephalomyelitis, Autoimmune, Experimental; Endocannabinoids; Female; Glycerides; Humans; Lymphocytes; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Multiple Sclerosis; Neuroprotective Agents; Patch-Clamp Techniques; Polyunsaturated Alkamides; Synaptic Transmission; Tissue Culture Techniques | 2007 |
Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Diterpenes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Drug Interactions; Electric Stimulation; Endocannabinoids; Female; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Trigeminal Ganglion; TRPV Cation Channels | 2008 |
Anandamide and Delta9-tetrahydrocannabinol directly inhibit cells of the immune system via CB2 receptors.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Camphanes; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Endocannabinoids; Female; Immune System; In Vitro Techniques; Lymphocytes; Mice; Mice, Inbred C3H; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB2; Rosette Formation | 2007 |
Evaluation of fatty acid amides in the carrageenan-induced paw edema model.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Cannabinoids; Carrageenan; Dexamethasone; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Edema; Endocannabinoids; Ethanolamines; Female; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Oleic Acids; Polyunsaturated Alkamides | 2008 |
Novel, potent THC/anandamide (hybrid) analogs.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cell Line; Cells, Cultured; Dronabinol; Drug Evaluation, Preclinical; Endocannabinoids; Humans; Mice; Models, Molecular; Molecular Structure; Polyunsaturated Alkamides; Structure-Activity Relationship | 2007 |
Cannabinoid activation of PPAR alpha; a novel neuroprotective mechanism.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cerebral Cortex; Cyclooxygenase 2; Dronabinol; Endocannabinoids; Fatty Acids, Unsaturated; Fenofibrate; HeLa Cells; Humans; I-kappa B Kinase; Ligands; Luciferases; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Neuroprotective Agents; Oleic Acids; Polyunsaturated Alkamides; PPAR alpha; Protein Binding; Recombinant Fusion Proteins; Transfection | 2007 |
Cannabinoid receptor agonists are mitochondrial inhibitors: a unified hypothesis of how cannabinoids modulate mitochondrial function and induce cell death.
Topics: Apoptosis; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoids; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Dronabinol; Electron Transport Complex I; Electron Transport Complex II; Electron Transport Complex III; Endocannabinoids; Humans; Hydrogen Peroxide; Lung Neoplasms; Membrane Potential, Mitochondrial; Mitochondria; Models, Biological; Oxygen Consumption; Polyunsaturated Alkamides | 2007 |
Attenuation of experimental autoimmune hepatitis by exogenous and endogenous cannabinoids: involvement of regulatory T cells.
Topics: Alanine Transaminase; Animals; Apoptosis; Arachidonic Acids; Aspartate Aminotransferases; Cannabinoid Receptor Modulators; Cells, Cultured; Chemokines; Concanavalin A; Cytokines; Disease Models, Animal; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Female; Hepatitis, Autoimmune; Hepatocytes; In Situ Nick-End Labeling; Leukocytes; Liver; Mice; Mice, Inbred C57BL; Mice, Knockout; Polyunsaturated Alkamides; Receptors, Cannabinoid; T-Lymphocytes, Regulatory; Time Factors; Treatment Outcome | 2008 |
Lack of a significant effect of cannabinoids upon the uptake of 2-deoxy-D-glucose by Caco-2 cells.
Topics: Arachidonic Acids; Caco-2 Cells; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Cyclohexanols; Deoxyglucose; Dronabinol; Endocannabinoids; Humans; Indoles; Intestinal Absorption; Piperidines; Polyunsaturated Alkamides; Pyrazoles | 2008 |
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.
Topics: Animals; Arachidonic Acids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
Apparent affinity estimates of rimonabant in combination with anandamide and chemical analogs of anandamide in rhesus monkeys discriminating Delta9-tetrahydrocannabinol.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Discrimination Learning; Discrimination, Psychological; Dronabinol; Drug Therapy, Combination; Endocannabinoids; Female; Injections, Intravenous; Macaca mulatta; Male; Molecular Structure; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Structure-Activity Relationship | 2009 |
Dynamic changes of the endogenous cannabinoid and opioid mesocorticolimbic systems during adolescence: THC effects.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cerebral Cortex; Chromatography, High Pressure Liquid; Dronabinol; Endocannabinoids; Enkephalin, Methionine; Glycerides; Limbic System; Male; Mass Spectrometry; Neostriatum; Neural Pathways; Nucleus Accumbens; Opioid Peptides; Polyunsaturated Alkamides; Prefrontal Cortex; Psychotropic Drugs; Radioimmunoassay; Rats; Rats, Long-Evans; Receptor, Cannabinoid, CB1; Receptors, Opioid, mu | 2008 |
Anandamide effects on 5-HT(3) receptors in vivo.
Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Dronabinol; Endocannabinoids; Freezing Reaction, Cataleptic; Male; Mice; Mice, Knockout; Motor Activity; Ondansetron; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Serotonin, 5-HT3; Serotonin 5-HT3 Receptor Antagonists | 2008 |
Fatty acid amide hydrolase inhibition heightens anandamide signaling without producing reinforcing effects in primates.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Behavior, Animal; Benzamides; Brain; Cannabinoid Receptor Modulators; Carbamates; Chromatography, Liquid; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Male; Polyunsaturated Alkamides; Rats; Rats, Wistar; Reinforcement Schedule; Reinforcement, Psychology; Saimiri; Self Administration | 2008 |
Effect of cannabinoids upon the uptake of folic acid by BeWo cells.
Topics: Arachidonic Acids; Carrier Proteins; Cell Culture Techniques; Cell Line, Tumor; Cyclohexanols; Dronabinol; Drug Administration Schedule; Endocannabinoids; Female; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Hydrogen-Ion Concentration; Indoles; Membrane Transport Proteins; Piperidines; Placenta; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cell Surface | 2009 |
Cannabinoid 1 receptor activation inhibits transient receptor potential vanilloid type 1 receptor-mediated cationic influx into rat cultured primary sensory neurons.
Topics: Animals; Arachidonic Acids; Bradykinin; Capsaicin; Cations, Divalent; Cells, Cultured; Cobalt; Dinoprostone; Dronabinol; Endocannabinoids; Female; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sensory Receptor Cells; TRPV Cation Channels | 2009 |
Discriminative stimulus properties of delta9-tetrahydrocannabinol (THC) in C57Bl/6J mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Nicotine; Phenylmethylsulfonyl Fluoride; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2009 |
Suppression of amygdalar endocannabinoid signaling by stress contributes to activation of the hypothalamic-pituitary-adrenal axis.
Topics: Amidohydrolases; Amygdala; Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Corticosterone; Dronabinol; Drug Interactions; Endocannabinoids; Hypothalamo-Hypophyseal System; Male; Microinjections; Piperidines; Pituitary-Adrenal System; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Restraint, Physical; Signal Transduction; Stress, Psychological | 2009 |
Chronic Delta9-tetrahydrocannabinol during adolescence increases sensitivity to subsequent cannabinoid effects in delayed nonmatch-to-position in rats.
Topics: Age Factors; Amphetamine; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Choice Behavior; Conditioning, Operant; Dopamine Uptake Inhibitors; Dronabinol; Drug Interactions; Endocannabinoids; Male; Muscarinic Antagonists; Polyunsaturated Alkamides; Psychotropic Drugs; Rats; Rats, Long-Evans; Scopolamine; Time Factors | 2010 |
Dopaminergic augmentation of delta-9-tetrahydrocannabinol (THC) discrimination: possible involvement of D(2)-induced formation of anandamide.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Brain; Conditioning, Operant; Discrimination, Psychological; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Male; Polyunsaturated Alkamides; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptors, Dopamine D1; Receptors, Dopamine D2; Up-Regulation | 2010 |
Pharmacological characterization of cannabinoid receptor activity in the rat-isolated ileum myenteric plexus-longitudinal muscle preparation.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclohexanols; Dronabinol; Electric Stimulation; Endocannabinoids; Female; Ileum; In Vitro Techniques; Male; Morpholines; Myenteric Plexus; Naphthalenes; Polyunsaturated Alkamides; Rats; Rats, Wistar; Receptors, Cannabinoid | 2010 |
Regulation of subthalamic neuron activity by endocannabinoids.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Modulators; Carbamates; Cerebral Cortex; Dose-Response Relationship, Drug; Dronabinol; Electrophysiology; Endocannabinoids; Globus Pallidus; Immunohistochemistry; Injections, Intraventricular; Male; Microinjections; Neurons; Piperidines; Polyunsaturated Alkamides; Prefrontal Cortex; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Subthalamic Nucleus | 2010 |
FAAH-/- mice display differential tolerance, dependence, and cannabinoid receptor adaptation after delta 9-tetrahydrocannabinol and anandamide administration.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Benzoxazines; Brain; Cannabinoid Receptor Modulators; Dose-Response Relationship, Drug; Dronabinol; Drug Tolerance; Endocannabinoids; Guanosine 5'-O-(3-Thiotriphosphate); Male; Marijuana Abuse; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Protein Binding; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sulfur Isotopes; Tritium | 2010 |
Inhibition of monoamine oxidase activity by cannabinoids.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Inhibitory Concentration 50; Iproniazid; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Morpholines; Naphthalenes; Polyunsaturated Alkamides; Swine | 2010 |
Cannabinoid-1 receptor activation induces reactive oxygen species-dependent and -independent mitogen-activated protein kinase activation and cell death in human coronary artery endothelial cells.
Topics: Acetylcysteine; Arachidonic Acids; Cell Death; Cell Line; Coronary Vessels; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Endothelial Cells; Humans; Mitogen-Activated Protein Kinases; Morpholines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reactive Oxygen Species; Receptor, Cannabinoid, CB1; Rimonabant; Signal Transduction | 2010 |
Effects of cannabinoids on capsaicin receptor activity following exposure of primary sensory neurons to inflammatory mediators.
Topics: Animals; Arachidonic Acids; Bradykinin; Capsaicin; Cells, Cultured; Cobalt; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Inflammation Mediators; Male; Nerve Growth Factor; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Sensory Receptor Cells; TRPV Cation Channels | 2010 |
The endocannabinoid system links gut microbiota to adipogenesis.
Topics: Adipogenesis; Adipose Tissue; Animals; Arachidonic Acids; Bacterial Translocation; Caco-2 Cells; Cannabinoid Receptor Modulators; Disease Models, Animal; Dronabinol; Endocannabinoids; Glycerides; Humans; Intestinal Mucosa; Intestines; Lipopolysaccharides; Male; Mice; Mice, Inbred C57BL; Myeloid Differentiation Factor 88; Obesity; Permeability; Piperidines; Polyunsaturated Alkamides; Prebiotics; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; RNA, Messenger | 2010 |
Temporal and spatial distribution of the cannabinoid receptors (CB1, CB2) and fatty acid amide hydroxylase in the rat ovary.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Blotting, Western; Cannabinoid Receptor Modulators; Corpus Luteum; Dronabinol; Endocannabinoids; Female; Granulosa Cells; Oocytes; Ovarian Follicle; Ovary; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2 | 2010 |
Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Cardiovascular Agents; Cell Line; Coronary Vessels; Dronabinol; Endocannabinoids; Humans; Indoles; Indomethacin; Lysophospholipids; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB2; Sphingosine; Vasodilation | 2010 |
Nigrostriatal denervation changes the effect of cannabinoids on subthalamic neuronal activity in rats.
Topics: Action Potentials; Analysis of Variance; Animals; Arachidonic Acids; Basal Ganglia; Benzoxazines; Cannabinoids; Chi-Square Distribution; Denervation; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Injections; Injections, Intraventricular; Male; Morpholines; Naphthalenes; Neural Inhibition; Neurons; Oxidopamine; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Substantia Nigra; Subthalamic Nucleus | 2011 |
Reinforcing and neurochemical effects of cannabinoid CB1 receptor agonists, but not cocaine, are altered by an adenosine A2A receptor antagonist.
Topics: Adenosine A2 Receptor Antagonists; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cocaine; Corpus Striatum; Dopamine; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Injections, Intravenous; Male; Marijuana Abuse; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A; Receptor, Cannabinoid, CB1; Receptors, Presynaptic; Reinforcement, Psychology; Saimiri; Self Administration; Xanthines | 2011 |
The endogenous cannabinoid anandamide shares discriminative stimulus effects with ∆(9)-tetrahydrocannabinol in fatty acid amide hydrolase knockout mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Behavior, Animal; Discrimination, Psychological; Dronabinol; Endocannabinoids; Gene Knockout Techniques; Male; Mice; Oleic Acids; Polyunsaturated Alkamides | 2011 |
Modeling of ligand binding to G protein coupled receptors: cannabinoid CB1, CB2 and adrenergic β 2 AR.
Topics: Amino Acid Motifs; Arachidonic Acids; Binding Sites; Dronabinol; Endocannabinoids; Fenoterol; Humans; Hydrogen Bonding; Indoles; Ligands; Molecular Dynamics Simulation; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Adrenergic, beta-2; Stereoisomerism; Thermodynamics | 2011 |
The fatty acid amide hydrolase inhibitor URB 597: interactions with anandamide in rhesus monkeys.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Discrimination, Psychological; Dronabinol; Drug Interactions; Drug Therapy, Combination; Endocannabinoids; Female; Macaca mulatta; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2011 |
Cannabinoid CB1 receptors regulate neuronal TNF-α effects in experimental autoimmune encephalomyelitis.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Corpus Striatum; Dizocilpine Maleate; Dronabinol; Encephalomyelitis, Autoimmune, Experimental; Endocannabinoids; Etanercept; Excitatory Postsynaptic Potentials; Female; Glutamic Acid; Immunoglobulin G; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Degeneration; Neurons; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Receptors, Tumor Necrosis Factor; Tumor Necrosis Factor-alpha | 2011 |
Inhibitory CB1 and activating/desensitizing TRPV1-mediated cannabinoid actions on CGRP release in rodent skin.
Topics: Animals; Arachidonic Acids; Calcitonin Gene-Related Peptide; Cannabinoid Receptor Modulators; Capsaicin; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Hot Temperature; Male; Mice; Mice, Knockout; Polyunsaturated Alkamides; Psychotropic Drugs; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1; Sensory System Agents; Skin; TRPV Cation Channels | 2011 |
The non-psychoactive plant cannabinoid, cannabidiol affects cholesterol metabolism-related genes in microglial cells.
Topics: Animals; Arachidonic Acids; beta-Cyclodextrins; Cannabidiol; Cell Death; Cell Line; Cholesterol; Culture Media, Serum-Free; Dronabinol; Endocannabinoids; Gene Expression Regulation; Interleukin-1beta; Lipid Metabolism; Lipopolysaccharides; Mice; Microglia; Oligonucleotide Array Sequence Analysis; Plants; Polyunsaturated Alkamides; RNA, Messenger; Time Factors | 2011 |
The anandamide transport inhibitor AM404 reduces the rewarding effects of nicotine and nicotine-induced dopamine elevations in the nucleus accumbens shell in rats.
Topics: Animals; Arachidonic Acids; Behavior, Addictive; Behavior, Animal; Conditioning, Psychological; Dopamine; Dronabinol; Endocannabinoids; Male; Motor Activity; Nicotine; Nicotinic Agonists; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Reward | 2012 |
Mixed signals: cannabinoid system offers new therapeutic possibilities as well as challenges.
Topics: Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoids; Dronabinol; Endocannabinoids; Glycerides; Humans; Neurodegenerative Diseases; Polyunsaturated Alkamides; Receptors, Cannabinoid; Signal Transduction | 2011 |
Cloning and pharmacological characterization of the dog cannabinoid CB₂receptor.
Topics: Amino Acid Sequence; Animals; Arachidonic Acids; Base Sequence; Benzoxazines; Binding, Competitive; Camphanes; CHO Cells; Cloning, Molecular; Colforsin; Cricetinae; Cricetulus; Cyclic AMP; Cyclohexanols; Dogs; Dronabinol; Endocannabinoids; Humans; Mice; Molecular Sequence Data; Morpholines; Naphthalenes; Pan troglodytes; Polyunsaturated Alkamides; Pyrazoles; Rats; Receptor, Cannabinoid, CB2; Sequence Alignment | 2011 |
Cannabinoid receptor 1 signaling in embryo neurodevelopment.
Topics: Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Chick Embryo; Chromatography, Liquid; Dronabinol; Embryo, Mammalian; Endocannabinoids; Endpoint Determination; Female; Glycerides; Mass Spectrometry; Mice; Neurogenesis; Polyunsaturated Alkamides; Prosencephalon; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Signal Transduction; Substance-Related Disorders | 2012 |
A common molecular basis for exogenous and endogenous cannabinoid potentiation of glycine receptors.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cell Line; Cells, Cultured; Computer Simulation; Dronabinol; Electrophysiological Phenomena; Endocannabinoids; Female; Humans; Hydrogen Bonding; Male; Models, Molecular; Mutagenesis, Site-Directed; Neurons; Patch-Clamp Techniques; Polyunsaturated Alkamides; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Glycine; Recombinant Proteins; Spinal Cord | 2012 |
The molecular basis for neuroimmune receptor signaling.
Topics: Analgesics, Opioid; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Modulators; Cannabinoids; Chemokine CXCL12; Dronabinol; Endocannabinoids; Female; HIV Envelope Protein gp120; HIV-1; Humans; Lymphocyte Activation; Lymphocytes; MicroRNAs; Morphine; Narcotics; Neostriatum; Nervous System; Neurons; Polyunsaturated Alkamides; Pregnancy; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, G-Protein-Coupled; Receptors, Opioid, mu; Signal Transduction; T-Lymphocytes; T-Lymphocytes, Cytotoxic | 2012 |
Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity.
Topics: 4-Aminopyridine; Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Carbamates; Corpus Striatum; Disease Models, Animal; Dronabinol; Endocannabinoids; Epilepsy; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Ganciclovir; Glutamic Acid; Lateral Ventricles; Lipopolysaccharides; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neural Stem Cells; Neuroprotective Agents; Polyunsaturated Alkamides; Stem Cells; Stroke | 2012 |
Endocannabinoids in nervous system health and disease: the big picture in a nutshell.
Topics: Arachidonic Acids; Brain; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Dronabinol; Electrical Synapses; Endocannabinoids; Glycerides; Humans; Inflammation; Neurodegenerative Diseases; Neurogenesis; Neuroprotective Agents; Nociceptors; Polyunsaturated Alkamides; Receptors, Cannabinoid; Synaptic Transmission | 2012 |
Palmitoylethanolamide: from endogenous cannabimimetic substance to innovative medicine for the treatment of cannabis dependence.
Topics: Amides; Arachidonic Acids; Dronabinol; Endocannabinoids; Ethanolamines; Humans; Marijuana Abuse; Models, Biological; Molecular Structure; Palmitic Acids; Polyunsaturated Alkamides; Substance Withdrawal Syndrome; TRPV Cation Channels | 2013 |
Do cannabinoids exhibit a tyramine-like effect?
Topics: Adrenergic Uptake Inhibitors; Animals; Arachidonic Acids; Benzoxazines; Cannabidiol; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Glycerides; Kidney Cortex; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Norepinephrine; Norepinephrine Plasma Membrane Transport Proteins; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Time Factors; Tyramine | 2013 |
In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569.
Topics: Allosteric Regulation; Amidohydrolases; Animals; Arachidonic Acids; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Cannabinoid Receptor Modulators; Catalepsy; Cyclohexanols; Dronabinol; Drug Evaluation; Eating; Endocannabinoids; Female; Hypothermia; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nociception; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Prior stimulation of the endocannabinoid system prevents methamphetamine-induced dopaminergic neurotoxicity in the striatum through activation of CB2 receptors.
Topics: Animals; Arachidonic Acids; Benzamides; Benzodioxoles; Cannabinoid Receptor Modulators; Carbamates; Central Nervous System Stimulants; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Methamphetamine; Mice, Inbred C57BL; Neostriatum; Neurotoxicity Syndromes; Piperidines; Polyunsaturated Alkamides; Random Allocation; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Tumor Necrosis Factor-alpha; Tyrosine 3-Monooxygenase | 2014 |
O-2050 facilitates noradrenaline release and increases the CB1 receptor inverse agonistic effect of rimonabant in the guinea pig hippocampus.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoid Receptor Antagonists; Cerebral Cortex; Dronabinol; Drug Interactions; Endocannabinoids; Glycerides; Guinea Pigs; Hippocampus; In Vitro Techniques; Male; Morpholines; Naphthalenes; Norepinephrine; Piperidines; Polyunsaturated Alkamides; Pyrans; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Endocannabinoid contribution to Δ9-tetrahydrocannabinol discrimination in rodents.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Brain; Discrimination, Psychological; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Monoacylglycerol Lipases; Polyunsaturated Alkamides; Rats; Receptor, Cannabinoid, CB1 | 2014 |
Type 1 cannabinoid receptor ligands display functional selectivity in a cell culture model of striatal medium spiny projection neurons.
Topics: Animals; Arachidonic Acids; Arrestin; Benzoxazines; Blotting, Western; Cannabinoid Receptor Agonists; Cannabinoids; Cells, Cultured; Corpus Striatum; Cyclohexanols; Dendritic Spines; Dronabinol; Endocannabinoids; Fluorescence Resonance Energy Transfer; Glycerides; GTP-Binding Proteins; Ligands; Luminescent Proteins; Mice; Models, Biological; Morpholines; Naphthalenes; Neurons; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1; Signal Transduction | 2014 |
Cannabinoid-induced changes in respiration of brain mitochondria.
Topics: Animals; Arachidonic Acids; Benzoxazines; Brain; Cannabidiol; Cannabinoid Receptor Agonists; Cannabinoids; Cell Respiration; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Endocannabinoids; Energy Metabolism; Mitochondria; Morpholines; Naphthalenes; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptor, Cannabinoid, CB1; Signal Transduction; Swine | 2014 |
Endocannabinoids control platelet activation and limit aggregate formation under flow.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Arachidonic Acids; Blood Platelets; Calcium; Cannabis; Collagen; Dronabinol; Endocannabinoids; Fibrinogen; Humans; Integrin beta3; Intracellular Signaling Peptides and Proteins; Phosphorylation; Platelet Activation; Platelet Aggregation; Platelet Membrane Glycoprotein IIb; Polyunsaturated Alkamides; Protein-Tyrosine Kinases; Receptor, Cannabinoid, CB2; Receptor, PAR-1; Signal Transduction; Syk Kinase; Thrombosis | 2014 |
Phenotypic assessment of THC discriminative stimulus properties in fatty acid amide hydrolase knockout and wildtype mice.
Topics: Amidohydrolases; Analysis of Variance; Animals; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cannabinoid Receptor Antagonists; Carbamates; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Glycerides; Male; Mice; Mice, Knockout; Piperazines; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant | 2015 |
Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amacrine Cells; Animals; Apoptosis; Arachidonic Acids; Cannabinoid Receptor Agonists; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; MAP Kinase Signaling System; Neuroprotective Agents; Nitric Oxide Synthase Type I; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2015 |
THC and endocannabinoids differentially regulate neuronal activity in the prefrontal cortex and hippocampus in the subchronic PCP model of schizophrenia.
Topics: Animals; Arachidonic Acids; Benzamides; Carbamates; Disease Models, Animal; Dronabinol; Endocannabinoids; Hippocampus; Male; Phencyclidine; Polyunsaturated Alkamides; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Schizophrenia; Up-Regulation | 2016 |
Self-administration of the anandamide transport inhibitor AM404 by squirrel monkeys.
Topics: Animals; Arachidonic Acids; Benzamides; Cannabinoid Receptor Antagonists; Carbamates; Cocaine; Dose-Response Relationship, Drug; Dronabinol; Drug-Seeking Behavior; Endocannabinoids; Male; Nicotine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Reinforcement, Psychology; Reward; Rimonabant; Saimiri; Self Administration | 2016 |
Comparisons of Δ9-Tetrahydrocannabinol and Anandamide on a Battery of Cognition-Related Behavior in Nonhuman Primates.
Topics: Animals; Arachidonic Acids; Attention; Behavior, Animal; Benzamides; Carbamates; Cognition; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Memory, Short-Term; Motivation; Piperidines; Polyunsaturated Alkamides; Psychomotor Performance; Pyrazoles; Reversal Learning; Rimonabant; Saimiri | 2016 |
Functional effects of cannabinoids during dopaminergic specification of human neural precursors derived from induced pluripotent stem cells.
Topics: Arachidonic Acids; Cannabinoid Receptor Agonists; DNA Methylation; Dopaminergic Neurons; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Fetal Blood; Humans; In Vitro Techniques; Induced Pluripotent Stem Cells; Neural Stem Cells; Neurogenesis; Polyunsaturated Alkamides | 2017 |
Just add water: cannabinoid discrimination in a water T-maze with FAAH(-/-) and FAAH(+/+) mice.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzodioxoles; Brain; Discrimination, Psychological; Dronabinol; Endocannabinoids; Glycerides; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Polyunsaturated Alkamides; Water | 2016 |
Hydrophobic Ligand Entry and Exit Pathways of the CB1 Cannabinoid Receptor.
Topics: Arachidonic Acids; Cannabinoid Receptor Agonists; Dronabinol; Endocannabinoids; Humans; Hydrophobic and Hydrophilic Interactions; Ligands; Lipid Bilayers; Molecular Dynamics Simulation; Polyunsaturated Alkamides; Receptor, Cannabinoid, CB1 | 2016 |
Functional Redundancy Between Canonical Endocannabinoid Signaling Systems in the Modulation of Anxiety.
Topics: Adaptation, Ocular; Animals; Anti-Anxiety Agents; Anxiety; Arachidonic Acids; Benzodioxoles; Brain; Cannabinoid Receptor Agonists; Cyclohexanols; Disease Models, Animal; Dronabinol; Endocannabinoids; Excitatory Postsynaptic Potentials; Glycerides; Heterocyclic Compounds, 1-Ring; Locomotion; Male; Mice; Mice, Inbred ICR; Piperidines; Polyunsaturated Alkamides; Pyridines; Signal Transduction | 2017 |
Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2.
Topics: Arachidonic Acids; Cannabinoids; Cells, Cultured; Cytochrome P-450 CYP2J2; Cytochrome P-450 Enzyme System; Dronabinol; Endocannabinoids; Epoxy Compounds; Humans; Polyunsaturated Alkamides | 2018 |
Adult Cellular Neuroadaptations Induced by Adolescent THC Exposure in Female Rats Are Rescued by Enhancing Anandamide Signaling.
Topics: Adaptation, Psychological; Animals; Arachidonic Acids; Benzamides; Carbamates; Dentate Gyrus; Depression; Dronabinol; Endocannabinoids; Female; Marijuana Abuse; Neurogenesis; Neuronal Plasticity; Polyunsaturated Alkamides; Prefrontal Cortex; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Sexual Maturation; Signal Transduction; Synapses; Tissue Culture Techniques | 2018 |
Effects of cannabis tetrahydrocannabinol on endocannabinoid homeostasis in human placenta.
Topics: Amidohydrolases; Arachidonic Acids; Cannabis; Dronabinol; Endocannabinoids; Female; Homeostasis; Humans; Placenta; Polyunsaturated Alkamides; Pregnancy; Psychotropic Drugs; Receptor, Cannabinoid, CB1 | 2019 |
Endogenous and synthetic cannabinoids induce the downregulation of cannabinoid CB1 receptor in retina.
Topics: Animals; Arachidonic Acids; Blotting, Western; Down-Regulation; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Female; Injections, Intraperitoneal; Male; MAP Kinase Signaling System; Phosphorylation; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Retina; Signal Transduction | 2019 |
Working out with weed.
Topics: Adult; Arachidonic Acids; Athletic Performance; Cannabidiol; Cannabis; Doping in Sports; Dronabinol; Endocannabinoids; Exercise; Female; Humans; Inflammation; Male; Marijuana Use; Motivation; Performance-Enhancing Substances; Polyunsaturated Alkamides; Reproducibility of Results; Young Adult | 2019 |
Differential effects of Δ9-tetrahydrocannabinol dosing on correlates of schizophrenia in the sub-chronic PCP rat model.
Topics: Animals; Arachidonic Acids; Disease Models, Animal; Dronabinol; Endocannabinoids; Glycogen Synthase Kinase 3 beta; Male; Motor Activity; Neurons; Phencyclidine; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Schizophrenia; Signal Transduction; Ventral Tegmental Area | 2020 |
Impact of tetrahydrocannabinol on the endocannabinoid 2-arachidonoylglycerol metabolism: ABHD6 and ABHD12 as novel players in human placenta.
Topics: Arachidonic Acids; Dronabinol; Endocannabinoids; Female; Glycerides; Humans; Monoacylglycerol Lipases; Placenta; Polyunsaturated Alkamides; Pregnancy; Psychotropic Drugs | 2020 |