dronabinol and am-356
dronabinol has been researched along with am-356 in 46 studies
Research
Studies (46)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 12 (26.09) | 18.2507 |
| 2000's | 27 (58.70) | 29.6817 |
| 2010's | 7 (15.22) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Buzard, DJ; Han, S; Jones, RM; Thatte, J | 1 |
| Griffin, G; Pertwee, RG | 1 |
| Fernández-Ruiz, JJ; García-Palomero, E; Lin, SY; Makriyannis, A; Ramos, JA; Romero, J | 1 |
| Fernández-Ruiz, JJ; Makriyannis, A; Muñoz, RM; Ramos, JA; Romero, J; Villanua, MA | 1 |
| Burkey, RT; Nation, JR | 1 |
| Brodkin, J; Moerschbaecher, JM | 1 |
| Aberman, J; Carriero, D; Hill, A; Lin, SY; Makriyannis, A; Salamone, JD | 1 |
| Corchero, J; Fernandez-Ruiz, JJ; Fuentes, JA; Manzanares, J; Ramos, JA; Romero, J | 1 |
| de Miguel, R; Fernández-Ruiz, JJ; García-Gil, L; González, S; Makriyannis, A; Muñoz, RM; Ramos, JA; Romero, J; Villanua, MA | 1 |
| Goutopoulos, A; Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A | 2 |
| Goutopoulos, A; Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A; Sheppard, R | 1 |
| Brown, S; Derleth, C; Hsieh, C; Mackie, K | 1 |
| Bonner, TI; Buckley, NE; Compton, DR; Járai, Z; Kunos, G; Lake, KD; Martin, BR; Mezey, E; Razdan, RK; Varga, K; Wagner, JA; Zimmer, A; Zimmer, AM | 1 |
| Järbe, TU; Lamb, RJ; Lin, S; Makriyannis, A | 2 |
| Breivogel, CS; Martin, BR; Rorrer, WK; Selley, DE; Sim-Selley, LJ; Zimmer, A; Zimmer, AM | 1 |
| Bátkai, S; Járai, Z; Kunos, G; Wagner, JA | 1 |
| Brune, K; Hinz, B; Pahl, A; Ramer, R | 1 |
| Darmani, NA | 1 |
| Järbe, TU; Lamb, RJ; Liu, Q; Makriyannis, A | 2 |
| Díaz-Laviada, I; Ruiz-Llorente, L; Sánchez, AM; Sánchez, MG | 1 |
| Baskfield, CY; Martin, BR; Wiley, JL | 1 |
| Kraft, B; Kress, HG; Wintersberger, W | 1 |
| Alici, T; Appel, JB | 1 |
| Grenard, P; Julien, B; Karsak, M; Li, L; Lotersztajn, S; Mallat, A; Teixeira-Clerc, F; Van Nhieu, JT; Zimmer, A | 1 |
| Järbe, TU; Liu, Q; Makriyannis, A | 1 |
| Brune, K; Hinz, B; Ramer, R; Rösch, S | 1 |
| Hille, B; Lauckner, JE; Mackie, K | 1 |
| Ahn, KH; D'Antona, AM; Kendall, DA | 1 |
| Cichewicz, DL; Haller, VL; Welch, SP | 1 |
| Goldberg, SR; Justinova, Z; Makriyannis, A; Piomelli, D; Solinas, M; Tanda, G; Vadivel, SK; Wertheim, CE; Yasar, S | 1 |
| Connor, M; Roberts, LA; Ross, HR | 1 |
| Ginsburg, BC; Lamb, RJ; McMahon, LR | 1 |
| DiPatrizio, NV; Järbe, TU; Li, C; Makriyannis, A | 1 |
| Hinz, B; Ramer, R | 2 |
| Järbe, TU; Li, C; Makriyannis, A; Vadivel, SK | 2 |
| Järbe, TU; Li, C; Liu, Q; Makriyannis, A | 1 |
| Börner, C; Höllt, V; Kraus, J; Schraven, B; Smida, M | 1 |
| Baskfield, CY; Matthew Walentiny, D; Vann, RE; Wiley, JL | 1 |
| Halikhedkar, A; Järbe, TU; LeMay, BJ; Makriyannis, A; Vadivel, SK; Wood, J; Zvonok, A | 1 |
| Kokona, D; Thermos, K | 1 |
| Papadogkonaki, S; Theodorakis, Κ; Thermos, K | 1 |
Reviews
1 review(s) available for dronabinol and am-356
| Article | Year |
|---|---|
Therapeutic utility of cannabinoid receptor type 2 (CB(2)) selective agonists.
Topics: Animals; Drug Design; Humans; Ligands; Models, Molecular; Molecular Conformation; Receptor, Cannabinoid, CB2; Structure-Activity Relationship; Substrate Specificity | 2013 |
Other Studies
45 other study(ies) available for dronabinol and am-356
| Article | Year |
|---|---|
A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens.
Topics: Adenosine Triphosphate; Animals; Arachidonic Acids; Clonidine; Dose-Response Relationship, Drug; Down-Regulation; Dronabinol; Drug Tolerance; Electric Stimulation; In Vitro Techniques; Injections, Intraperitoneal; Male; Mice; Morphine; Muscle Contraction; Muscle, Smooth; Neuromuscular Junction; Norepinephrine; Receptors, Opioid; Vas Deferens | 1995 |
Extrapyramidal effects of methanandamide, an analog of anandamide, the endogenous CB1 receptor ligand.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Dose-Response Relationship, Drug; Dronabinol; Extrapyramidal Tracts; Ligands; Male; Motor Activity; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Stereotyped Behavior | 1996 |
Time course of the effects of different cannabimimetics on prolactin and gonadotrophin secretion: evidence for the presence of CB1 receptors in hypothalamic structures and their involvement in the effects of cannabimimetics.
Topics: Animals; Arachidonic Acids; Autoradiography; Dronabinol; Endocannabinoids; Gonadotropins, Pituitary; Hypothalamus; Male; Piperidines; Polyunsaturated Alkamides; Prolactin; Pyrazoles; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Time Factors | 1997 |
(R)-methanandamide, but not anandamide, substitutes for delta 9-THC in a drug-discrimination procedure.
Topics: Animals; Arachidonic Acids; Cannabinoids; Cyclohexanols; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Generalization, Stimulus; Hallucinogens; Male; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley | 1997 |
SR141716A antagonizes the disruptive effects of cannabinoid ligands on learning in rats.
Topics: Animals; Arachidonic Acids; Cannabinoids; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Learning; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rimonabant | 1997 |
A detailed characterization of the effects of four cannabinoid agonists on operant lever pressing.
Topics: Animals; Arachidonic Acids; Benzoxazines; Conditioning, Operant; Cyclohexanols; Dronabinol; Male; Morpholines; Naphthalenes; Rats | 1998 |
Chronic administration of cannabinoids regulates proenkephalin mRNA levels in selected regions of the rat brain.
Topics: Animals; Arachidonic Acids; Brain Chemistry; Corpus Striatum; Cyclohexanols; Dronabinol; Drug Tolerance; Enkephalins; In Situ Hybridization; Male; Mammillary Bodies; Nucleus Accumbens; Organ Specificity; Paraventricular Hypothalamic Nucleus; Periaqueductal Gray; Protein Precursors; Rats; Rats, Sprague-Dawley; RNA, Messenger; Time Factors; Ventromedial Hypothalamic Nucleus | 1998 |
Effects of cannabinoids on prolactin and gonadotrophin secretion: involvement of changes in hypothalamic gamma-aminobutyric acid (GABA) inputs.
Topics: Animals; Arachidonic Acids; Dronabinol; gamma-Aminobutyric Acid; Gonadotropins; Hypothalamus; Male; Prolactin; Protein Binding; Rats; Rats, Wistar; Receptors, Cannabinoid; Receptors, Drug; RNA, Messenger | 1998 |
Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats.
Topics: Animals; Arachidonic Acids; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Generalization, Response; Hallucinogens; Male; Morphine; Narcotics; Rats; Rats, Sprague-Dawley | 1998 |
Effects of delta-9-tetrahydrocannabinol and (R)-methanandamide on open-field behavior in rats.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Defecation; Dronabinol; Grooming; Male; Psychomotor Performance; Psychotropic Drugs; Rats; Rats, Sprague-Dawley; Urination | 1998 |
Internalization and recycling of the CB1 cannabinoid receptor.
Topics: Acids; Ammonium Chloride; Animals; Arachidonic Acids; Benzoxazines; Calcium Channel Blockers; Cannabinoids; Cells, Cultured; Clathrin; Coated Vesicles; Cyclohexanols; Dronabinol; Drug Tolerance; Endocytosis; Endosomes; Excitatory Amino Acid Antagonists; GTP-Binding Proteins; Immunosuppressive Agents; Morpholines; Mutagenesis; Naphthalenes; Phosphorylation; Piperidines; Protein Binding; Protein Structure, Tertiary; Pyrazoles; Rats; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Transfection; Up-Regulation; Virulence Factors, Bordetella | 1999 |
Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.
Topics: Animals; Arachidonic Acids; Cannabidiol; Cannabinoids; Dronabinol; Endocannabinoids; Endothelium, Vascular; Mesenteric Arteries; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Knockout; Nitric Oxide; Piperidines; Polyunsaturated Alkamides; Potassium Channels; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Receptor, Cannabinoid, CB2; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vasodilation; Vasodilator Agents | 1999 |
Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats: a systematic replication.
Topics: Animals; Arachidonic Acids; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Generalization, Stimulus; Hallucinogens; Male; Rats; Rats, Sprague-Dawley; Reinforcement Schedule | 2000 |
Effects of Delta 9-tetrahydrocannabinol, (R)-methanandamide, SR 141716,and d-amphetamine before and during daily Delta 9-tetrahydrocannabinol dosing.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Dextroamphetamine; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Drug Tolerance; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Rimonabant; Time Factors | 2000 |
Agonist efficacy and receptor efficiency in heterozygous CB1 knockout mice: relationship of reduced CB1 receptor density to G-protein activation.
Topics: Animals; Arachidonic Acids; Benzoxazines; Binding Sites; Brain; Cannabinoids; Cell Membrane; Cerebellum; Corpus Striatum; Crosses, Genetic; Dronabinol; Female; Globus Pallidus; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Gyrus Cinguli; Heterozygote; Hippocampus; Kinetics; Mice; Mice, Inbred C57BL; Mice, Knockout; Morpholines; Naphthalenes; Organ Specificity; Receptors, Cannabinoid; Receptors, Drug | 2001 |
Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors.
Topics: Animals; Arachidonic Acids; Blood Pressure; Brain; Cannabinoids; Coronary Circulation; Coronary Vessels; Dronabinol; Endocannabinoids; Heart Rate; Hemodynamics; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Vascular Resistance; Vasodilation | 2001 |
(R)-methanandamide and Delta 9-THC as discriminative stimuli in rats: tests with the cannabinoid antagonist SR-141716 and the endogenous ligand anandamide.
Topics: Adjuvants, Immunologic; Animals; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Psychotropic Drugs; Pyrazoles; Rats; Rats, Sprague-Dawley; Reaction Time; Rimonabant | 2001 |
R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism.
Topics: Analgesics, Non-Narcotic; Arachidonic Acids; Blotting, Western; Brain Neoplasms; Cannabinoid Receptor Modulators; Cell Line; Central Nervous System; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Enzyme Activation; Enzyme Inhibitors; Flavonoids; Glioma; Humans; Imidazoles; Interleukin-1; Isoenzymes; Membrane Proteins; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphorylation; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Pyridines; Receptors, Cannabinoid; Receptors, Drug; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Tumor Cells, Cultured; Virulence Factors, Bordetella | 2001 |
The potent emetogenic effects of the endocannabinoid, 2-AG (2-arachidonoylglycerol) are blocked by delta(9)-tetrahydrocannabinol and other cannnabinoids.
Topics: Animals; Antiemetics; Arachidonic Acids; Cannabinoid Receptor Modulators; Cannabinoids; Cyclohexanols; Dose-Response Relationship, Drug; Dronabinol; Emetics; Endocannabinoids; Female; Glycerides; Humans; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Receptors, Cannabinoid; Receptors, Drug; Rimonabant; Shrews | 2002 |
(R)-Methanandamide and delta9-tetrahydrocannabinol-induced operant rate decreases in rats are not readily antagonized by SR-141716A.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Conditioning, Operant; Dronabinol; Drug Interactions; Hallucinogens; Injections, Intraperitoneal; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2003 |
Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(2) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction.
Topics: 3-Phosphoinositide-Dependent Protein Kinases; Animals; Arachidonic Acids; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Cell Survival; Cells, Cultured; Cerebellum; Chromones; Dronabinol; Flavonoids; Gene Expression Regulation; Humans; Liver; Lymphocytes; Male; Microscopy, Fluorescence; Mitogen-Activated Protein Kinases; Morpholines; Nerve Growth Factor; PC12 Cells; Phosphorylation; Piperidines; Polymerase Chain Reaction; Prostate; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Signal Transduction; Spleen | 2003 |
Differential effects of delta9-tetrahydrocannabinol and methanandamide in CB1 knockout and wild-type mice.
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dronabinol; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant | 2004 |
Cannabinoid receptor-independent suppression of the superoxide generation of human neutrophils (PMN) by CP55 940, but not by anandamide.
Topics: Adult; Arachidonic Acids; Cyclohexanols; Dronabinol; Endocannabinoids; Female; Humans; Male; Neutrophils; Polyunsaturated Alkamides; Receptors, Cannabinoid; Superoxides | 2004 |
Increasing the selectivity of the discriminative stimulus effects of delta 9-tetrahydrocannabinol: complete substitution with methanandamide.
Topics: Animals; Arachidonic Acids; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Rats; Rats, Sprague-Dawley; Reaction Time | 2004 |
Antifibrogenic role of the cannabinoid receptor CB2 in the liver.
Topics: Adult; Aged; Animals; Apoptosis; Arachidonic Acids; Cell Division; Cells, Cultured; Dronabinol; Endocannabinoids; Female; Fibroblasts; Glycerides; Humans; Liver; Liver Cirrhosis; Male; Mice; Mice, Knockout; Middle Aged; Myocytes, Smooth Muscle; Rats; Receptor, Cannabinoid, CB2 | 2005 |
Antagonism of discriminative stimulus effects of delta(9)-THC and (R)-methanandamide in rats.
Topics: Animals; Arachidonic Acids; Camphanes; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Drug Antagonism; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Stereoisomerism | 2006 |
R(+)-methanandamide and other cannabinoids induce the expression of cyclooxygenase-2 and matrix metalloproteinases in human nonpigmented ciliary epithelial cells.
Topics: Arachidonic Acids; Cannabinoids; Cells, Cultured; Cilia; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Dronabinol; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Enzymologic; Humans; Matrix Metalloproteinases; Nitrobenzenes; p38 Mitogen-Activated Protein Kinases; Phosphorylation; RNA, Messenger; Sulfonamides; Tissue Inhibitor of Metalloproteinase-1 | 2006 |
The cannabinoid agonist WIN55,212-2 increases intracellular calcium via CB1 receptor coupling to Gq/11 G proteins.
Topics: Analgesics; Animals; Arachidonic Acids; Benzoxazines; Calcium; Cannabinoids; Cell Line; Cyclohexanols; Cytoplasm; DNA, Complementary; Dronabinol; Endocannabinoids; Endoplasmic Reticulum; Excitatory Amino Acid Antagonists; Fluorescent Dyes; Fura-2; Glycerides; GTP-Binding Protein alpha Subunits, Gq-G11; Hippocampus; Humans; Immunosuppressive Agents; Morpholines; Naphthalenes; Neurons; Pertussis Toxin; Piperidines; Protein Binding; Protein Conformation; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Ryanodine; Time Factors; Type C Phospholipases | 2005 |
Mutations of CB1 T210 produce active and inactive receptor forms: correlations with ligand affinity, receptor stability, and cellular localization.
Topics: Amino Acid Sequence; Amino Acid Substitution; Arachidonic Acids; Benzoxazines; Cells, Cultured; Cyclic AMP; Dronabinol; Drug Stability; Guanosine 5'-O-(3-Thiotriphosphate); Hot Temperature; Humans; Kidney; Ligands; Morpholines; Mutation; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Threonine | 2006 |
Non-cannabinoid CB1, non-cannabinoid CB2 antinociceptive effects of several novel compounds in the PPQ stretch test in mice.
Topics: Acetaminophen; Amides; Analgesics; Animals; Arachidonic Acids; Benzamides; Benzoquinones; Camphanes; Capsaicin; Carbamates; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ethanolamines; Hyperalgesia; Male; Mesencephalon; Mice; Mice, Inbred ICR; Narcotic Antagonists; Pain; Palmitic Acids; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Opioid; Rimonabant; Spinal Cord; TRPV Cation Channels | 2006 |
Discriminative stimulus functions of AM-1346, a CB1R selective anandamide analog in rats trained with Delta9-THC or (R)-methanandamide (AM-356).
Topics: Analysis of Variance; Animals; Arachidonic Acids; Dextroamphetamine; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Hallucinogens; Injections, Intraperitoneal; Male; Morphine; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Regression Analysis; Reinforcement Schedule; Rimonabant; Time Factors | 2006 |
The endogenous cannabinoid anandamide produces delta-9-tetrahydrocannabinol-like discriminative and neurochemical effects that are enhanced by inhibition of fatty acid amide hydrolase but not by inhibition of anandamide transport.
Topics: Amidohydrolases; Animals; Arachidonic Acids; Benzamides; Biological Transport, Active; Brain Chemistry; Carbamates; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Furans; Hallucinogens; Injections, Intraperitoneal; Injections, Intravenous; Male; Microdialysis; Nucleus Accumbens; Polyunsaturated Alkamides; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Reinforcement Schedule; TRPV Cation Channels | 2007 |
Methanandamide activation of a novel current in mouse trigeminal ganglion sensory neurons in vitro.
Topics: Animals; Arachidonic Acids; Calcium Channel Blockers; Diterpenes; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Dronabinol; Drug Interactions; Electric Stimulation; Endocannabinoids; Female; In Vitro Techniques; Male; Membrane Potentials; Mice; Mice, Inbred C57BL; Mice, Knockout; Neurons, Afferent; Patch-Clamp Techniques; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rimonabant; Trigeminal Ganglion; TRPV Cation Channels | 2008 |
Cannabinoid agonists differentially substitute for the discriminative stimulus effects of Delta(9)-tetrahydrocannabinol in C57BL/6J mice.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cannabinoids; Cyclohexanols; Data Interpretation, Statistical; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Drug Interactions; Hallucinogens; Male; Mice; Mice, Inbred C57BL; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Receptor, Cannabinoid, CB1; Reinforcement Schedule; Rimonabant | 2008 |
Effects of AM1346, a high-affinity CB1 receptor selective anandamide analog, on open-field behavior in rats.
Topics: Animals; Arachidonic Acids; Behavior, Animal; Defecation; Dose-Response Relationship, Drug; Dronabinol; Drug Inverse Agonism; Exploratory Behavior; Grooming; Male; Motor Activity; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Stereotyped Behavior; Vocalization, Animal | 2007 |
Inhibition of cancer cell invasion by cannabinoids via increased expression of tissue inhibitor of matrix metalloproteinases-1.
Topics: Arachidonic Acids; Biocompatible Materials; Cannabinoid Receptor Antagonists; Cannabinoids; Cell Movement; Collagen; Cytological Techniques; Down-Regulation; Dronabinol; Drug Combinations; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; HeLa Cells; Humans; Immunoblotting; Laminin; Lung Neoplasms; Matrix Metalloproteinase 1; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Proteoglycans; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tissue Inhibitor of Metalloproteinase-1; Transfection; TRPV Cation Channels; Uterine Cervical Neoplasms | 2008 |
Discriminative stimulus effects of the cannabinoid CB1 receptor antagonist rimonabant in rats.
Topics: Animals; Arachidonic Acids; Avoidance Learning; Camphanes; Discrimination Learning; Discrimination, Psychological; Dose-Response Relationship, Drug; Drinking; Dronabinol; Hallucinogens; Indoles; Injections, Intraperitoneal; Lithium Chloride; Male; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Rimonabant; Taste | 2008 |
Discriminative stimulus functions in rats of AM1346, a high-affinity CB1R selective anandamide analog.
Topics: Animals; Arachidonic Acids; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Ligands; Male; Piperidines; Polyunsaturated Alkamides; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant; Structure-Activity Relationship | 2009 |
Cannabinoid receptor type 1- and 2-mediated increase in cyclic AMP inhibits T cell receptor-triggered signaling.
Topics: Arachidonic Acids; Cannabinoids; Cell Proliferation; CSK Tyrosine-Protein Kinase; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dronabinol; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Indoles; Interleukin-2; Jurkat Cells; Lymphocyte Activation; Lymphocyte Specific Protein Tyrosine Kinase p56(lck); Morpholines; Multiple Sclerosis; Phosphorylation; Protein-Tyrosine Kinases; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Receptors, Antigen, T-Cell; Signal Transduction; src-Family Kinases; T-Lymphocytes | 2009 |
Discriminative stimulus functions of methanandamide and delta(9)-THC in rats: tests with aminoalkylindoles (WIN55,212-2 and AM678) and ethanol.
Topics: Animals; Arachidonic Acids; Benzoxazines; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Ethanol; Indoles; Male; Morpholines; Naphthalenes; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Signal Transduction | 2010 |
Cyclooxygenase-2 and tissue inhibitor of matrix metalloproteinases-1 confer the antimigratory effect of cannabinoids on human trabecular meshwork cells.
Topics: Arachidonic Acids; Cell Line, Transformed; Cell Migration Inhibition; Cell Survival; Cyclooxygenase 2; Dronabinol; Humans; Tissue Inhibitor of Metalloproteinase-1; Trabecular Meshwork | 2010 |
Dissimilar cannabinoid substitution patterns in mice trained to discriminate Δ(9)-tetrahydrocannabinol or methanandamide from vehicle.
Topics: Animals; Arachidonic Acids; Cyclohexanols; Discrimination Learning; Dose-Response Relationship, Drug; Dronabinol; Female; Generalization, Stimulus; Male; Mice; Mice, Inbred C57BL; Piperidines; Psychotropic Drugs; Pyrazoles; Receptor, Cannabinoid, CB1; Rimonabant; Sex Factors | 2011 |
Differentiation between low- and high-efficacy CB1 receptor agonists using a drug discrimination protocol for rats.
Topics: Animals; Arachidonic Acids; Benzoxazines; Cyclic AMP; Cyclohexanols; Discrimination, Psychological; Dose-Response Relationship, Drug; Dronabinol; Indoles; Isomerism; Male; Molecular Structure; Morpholines; Naphthalenes; Piperidines; Pyrazoles; Random Allocation; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Rimonabant | 2014 |
Synthetic and endogenous cannabinoids protect retinal neurons from AMPA excitotoxicity in vivo, via activation of CB1 receptors: Involvement of PI3K/Akt and MEK/ERK signaling pathways.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amacrine Cells; Animals; Apoptosis; Arachidonic Acids; Cannabinoid Receptor Agonists; Choline O-Acetyltransferase; Dose-Response Relationship, Drug; Dronabinol; Endocannabinoids; Enzyme Inhibitors; Excitatory Amino Acid Agonists; Fluorescent Antibody Technique, Indirect; In Situ Nick-End Labeling; Intravitreal Injections; Male; MAP Kinase Signaling System; Neuroprotective Agents; Nitric Oxide Synthase Type I; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1 | 2015 |
Endogenous and synthetic cannabinoids induce the downregulation of cannabinoid CB1 receptor in retina.
Topics: Animals; Arachidonic Acids; Blotting, Western; Down-Regulation; Dronabinol; Endocannabinoids; Excitatory Amino Acid Antagonists; Female; Injections, Intraperitoneal; Male; MAP Kinase Signaling System; Phosphorylation; Polyunsaturated Alkamides; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Real-Time Polymerase Chain Reaction; Receptor, Cannabinoid, CB1; Retina; Signal Transduction | 2019 |