drimane and alpha-chymotrypsin

One new drimane-type sesquiterpenoid, 3 β-angeloyloxy-7-epifutronolide (1), and one new natural product, polygonumate (2), along with six known drimane-type sesquiterpenes [dendocarbin L (3), (+) winterin (4), (+) fuegin (5), changweikangic acid A (6), futronolide (7), and 7-ketoisodrimenin (8)] were isolated from the whole plant of Polygonum hydropiper Linn. Their structures were determined using spectroscopic techniques. Single-crystal X-ray diffraction study on dendocarbin L (3) and ¹³C-NMR spectroscopic data of (+) winterin (4) are described for the first time. Compound 6 was evaluated for inhibitions of α-chymotrypsin, acetylcholinesterase, and butyrylcholinesterase enzymes.

Topics: Acetylcholinesterase; Butyrylcholinesterase; Chymotrypsin; Crystallography, X-Ray; Magnetic Resonance Spectroscopy; Molecular Structure; Plant Extracts; Plants, Medicinal; Polycyclic Sesquiterpenes; Polygonum; Sesquiterpenes; X-Ray Diffraction