Page last updated: 2024-08-24

draflazine and adenosine

draflazine has been researched along with adenosine in 33 studies

Research

Studies (33)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	28 (84.85)	18.2507
2000's	3 (9.09)	29.6817
2010's	2 (6.06)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Heitman, LH; IJzerman, AP; Vlachodimou, A	1
Aksnes, G; Ilebekk, A; Kirkebøen, KA; Lande, K	1
Chang-Chun, C; Flameng, W; Masuda, M; Möllhoff, T; Van Belle, H	1
Flameng, W; Möllhoff, T; Sukehiro, S; Van Aken, H; Van Belle, H	1
Chen, CC; Demeulemeester, A; Flameng, W; Hendrikx, M; Masuda, M; Van Belle, H	1
Van Belle, H; Ver Donck, KL; Verheyen, WJ	1
Van Belle, H	1
Bootsma, G; de Vries, A; Rongen, GA; Smits, P; Thien, T; Ver Donck, K	1
De Abreu, RA; Rongen, GA; Smits, P; Thien, T; Van Belle, H; Ver Donck, K; Willemsen, JJ	1
Belardinelli, L; Bruns, RF; Dennis, D; Kollias-Baker, C; Linden, J; Ruble, J	1
Belardinelli, L; Kollias-Baker, C; Pelleg, A; Xu, J	1
Beukers, MW; IJzerman, AP; Kerkhof, CJ; Soudijn, W	1
Parratt, JR; Van Belle, H; Wainwright, CL	1
Hammond, JR; Jones, KW	1
de Haan, HH; de Haan, J; Hasaart, TH; Van Belle, H; Van Reempts, JL	1
Van Belle, H; Ver Donck, K; Verheyen, W	1
Galiñanes, M; Hearse, DJ; Qiu, Y; Van Belle, H	1
Lambrou, J; Lenders, JW; Rongen, GA; Smits, P; Thien, T; Van Belle, H; Willemsen, JJ	1
Belardinelli, L; Dennis, DM; Martens, JR; Raatikainen, MJ	1
Crabbé, R; Danhof, M; Dupont, A; Heykants, J; Jacqmin, P; Snoeck, E; Van Belle, H; Van Gool, R; Van Peer, A; Ver Donck, K; Woestenborghs, R	1
Ishizaki, N; Jin, MB; Starzl, TE; Subbotin, V; Tanaka, H; Todo, S; Zhang, S; Zhu, Y	1
Lasley, RD; Martin, BJ; Mentzer, RM	1
Danhof, M; Dupont, AG; Heykants, J; Jacqmin, P; Piotrovskij, V; Snoeck, E; Van Belle, H; Van Bortel, L; Van Gool, R; Van Peer, A; Ver Donck, K; Woestenborghs, R	1
Grund, F; Ilebekk, A; Jynge, P; Kirkebøen, KA; Offstad, J; Sommerschild, HT	1
Belardinelli, L; Dennis, DM; Lozza, G; Monopoli, A; Olsson, RA; Ongini, E; Shryock, JC; Snowdy, S; Zhang, Y	1
Danhof, M; Dupont, AG; Jacqmin, P; Snoeck, E; Van Belle, H; Van Peer, A; Ver Donck, K	1
Deussen, A; Kelm, M; Schäfer, S; Stappert, M	1
Abbink-Zandbergen, EJ; Lutterman, JA; Schaper, NC; Smits, P; Tack, CJ; Vervoort, G	1
Deindl, E; Ilebekk, A; Jynge, P; Kirkebøen, KA; Lunde, PK; Sommerschild, HT	1
Kanegae, Y; Kawachi, Y; Masuda, M; Miyamoto, K; Nishida, T; Tominaga, R; Yasui, H	1
Karasawa, A; Katagiri, C; Kusaka, H; Mizutani, M; Nan-ya, K; Nishikawa, S; Noji, T; Sano, J	1
Baldwin, SA; Cass, CE; Damaraju, V; Paproski, RJ; Tackaberry, T; Visser, F; Young, JD; Zhang, J	1
Fong, M; Kambayashi, J; Liu, Y; Yoshitake, M	1

Trials

3 trial(s) available for draflazine and adenosine

Article	Year
High-grade nucleoside transport inhibition stimulates ventilation in humans. Journal of clinical pharmacology, 1995, Volume: 35, Issue:4 Topics: Adenosine; Adult; Biological Transport; Cross-Over Studies; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Male; Middle Aged; Nucleosides; Piperazines; Platelet Aggregation Inhibitors; Plethysmography; Respiration; Thorax; Tidal Volume	1995
Hemodynamic and neurohumoral effects of various grades of selective adenosine transport inhibition in humans. Implications for its future role in cardioprotection. The Journal of clinical investigation, 1995, Volume: 95, Issue:2 Topics: Adenosine; Adult; Blood Pressure; Caffeine; Carrier Proteins; Cross-Over Studies; Diastole; Dose-Response Relationship, Drug; Double-Blind Method; Epinephrine; Heart Rate; Humans; Infusions, Intra-Arterial; Injections, Intravenous; Male; Membrane Proteins; Middle Aged; Norepinephrine; Nucleoside Transport Proteins; Piperazines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Antagonists; Reference Values; Systole; Vasodilation	1995
Population analysis of the non linear red blood cell partitioning and the concentration-effect relationship of draflazine following various infusion rates. British journal of clinical pharmacology, 1997, Volume: 43, Issue:6 Topics: Adenosine; Adult; Area Under Curve; Binding, Competitive; Cohort Studies; Dose-Response Relationship, Drug; Double-Blind Method; Erythrocyte Count; Erythrocytes; Half-Life; Humans; Injections, Intravenous; Male; Middle Aged; Piperazines; Platelet Aggregation Inhibitors; Regression Analysis; Software; White People	1997

Other Studies

30 other study(ies) available for draflazine and adenosine

Article	Year
Label-free detection of transporter activity via GPCR signalling in living cells: A case for SLC29A1, the equilibrative nucleoside transporter 1. Scientific reports, 2019, 09-24, Volume: 9, Issue:1 Topics: Cell Line, Tumor; Equilibrative Nucleoside Transporter 1; Humans; Ligands; Membrane Transport Proteins; Osteosarcoma; Receptors, G-Protein-Coupled; Receptors, Purinergic P1; Signal Transduction	2019
Role of adenosine for reactive hyperemia in normal and stunned porcine myocardium. The American journal of physiology, 1992, Volume: 263, Issue:4 Pt 2 Topics: Adenosine; Adenosine Deaminase; Animals; Coronary Disease; Female; Hemodynamics; Hyperemia; Male; Myocardial Reperfusion Injury; Piperazines; Reference Values; Swine	1992
Effects of nucleoside transport inhibition on long-term ex vivo preservation of canine hearts. The Journal of thoracic and cardiovascular surgery, 1992, Volume: 104, Issue:6 Topics: Adenine Nucleotides; Adenosine; Animals; Biological Transport; Cardioplegic Solutions; Creatine Kinase; Dogs; Hypoxanthines; In Vitro Techniques; Inosine; Myocardial Reperfusion; Myocardium; Organ Preservation; Piperazines; Purine Nucleosides; Time Factors; Ventricular Function, Left	1992
Successful transplantation after long-term preservation of dog hearts. Anesthesiology, 1992, Volume: 77, Issue:2 Topics: Adenosine; Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphate; Animals; Dogs; Heart; Heart Transplantation; Inosine; Myocardial Reperfusion Injury; Myocardium; Organ Preservation; Piperazines; Time Factors	1992
Cardioprotective effects of nucleoside transport inhibition in rabbit hearts. The Annals of thoracic surgery, 1991, Volume: 52, Issue:6 Topics: Adenosine; Animals; Cardiac Output; Coronary Circulation; Inosine; Myocardial Reperfusion Injury; Myocardium; Piperazines; Rabbits	1991
Nucleoside transport inhibition and fMLP-stimulated whole blood luminescence. Journal of molecular and cellular cardiology, 1991, Volume: 23, Issue:7 Topics: Adenosine; Biological Transport; Dilazep; Dipyridamole; Humans; Luminescent Measurements; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Piperazines; Respiratory Burst	1991
Myocardial protection by nucleoside transport inhibition. Transplantation proceedings, 1995, Volume: 27, Issue:5 Topics: Adenine Nucleotides; Adenosine; Animals; Biological Transport; Cardiotonic Agents; Heart; Humans; In Vitro Techniques; Myocardial Ischemia; Myocardium; Piperazines	1995
Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. Circulation research, 1994, Volume: 75, Issue:6 Topics: Adenosine; Allosteric Regulation; Animals; Binding Sites; Brain; Bundle of His; Drug Synergism; Female; Guinea Pigs; Heart; Humans; In Vitro Techniques; Male; Membranes; Myocardium; Piperazines; Radioligand Assay; Receptors, Purinergic P1; Thiophenes	1994
Novel approach for enhancing atrioventricular nodal conduction delay mediated by endogenous adenosine. Circulation research, 1994, Volume: 75, Issue:6 Topics: Adenosine; Animals; Atrioventricular Node; Bundle of His; Coronary Vessels; Female; Guinea Pigs; Hypoxia; In Vitro Techniques; Male; Piperazines; Receptors, Purinergic P1; Thiophenes; Tubercidin; Vasodilation	1994
Nucleoside transport inhibition and platelet aggregation in human blood: R75231 and its enantiomers, draflazine and R88016. European journal of pharmacology, 1994, Jan-01, Volume: 266, Issue:1 Topics: Adenosine; Adenosine Diphosphate; Binding Sites; Biological Transport; Blood Platelets; Erythrocytes; Humans; Piperazines; Platelet Aggregation; Platelet Aggregation Inhibitors; Radioligand Assay; Stereoisomerism; Thioinosine	1994
The antiarrhythmic effects of the nucleoside transporter inhibitor, R75231, in anaesthetized pigs. British journal of pharmacology, 1993, Volume: 109, Issue:2 Topics: Adenosine; Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Blood Pressure; Coronary Vessels; Dose-Response Relationship, Drug; Electrocardiography; Myocardial Ischemia; Nucleosides; Piperazines; Swine; Ventricular Fibrillation; Ventricular Function	1993
Interaction of the mioflazine derivative R75231 with the nucleoside transporter: evidence for positive cooperativity. European journal of pharmacology, 1993, Jul-15, Volume: 246, Issue:2 Topics: Adenosine; Animals; Binding, Competitive; Carrier Proteins; Cerebral Cortex; Erythrocyte Membrane; Half-Life; Humans; In Vitro Techniques; Kinetics; Membrane Proteins; Nucleoside Transport Proteins; Piperazines; Rabbits; Synaptosomes; Thioinosine; Uridine	1993
The effect of adenosine transport inhibition on cardiovascular function and survival after severe asphyxia in fetal lambs. Pediatric research, 1993, Volume: 33, Issue:2 Topics: Adenosine; Animals; Biological Transport, Active; Blood Pressure; Cardiovascular System; Coronary Circulation; Female; Fetal Hypoxia; Heart Rate, Fetal; Oxygen; Piperazines; Pregnancy; Sheep	1993
Role of nucleoside transport inhibition and endogenous adenosine in prevention of catecholamine induced death in rabbits. Cardiovascular research, 1993, Volume: 27, Issue:1 Topics: Adenosine; Aminophylline; Animals; Biological Transport, Active; Epinephrine; Female; Heart; Male; Norepinephrine; Nucleosides; Piperazines; Rabbits	1993
Metabolic and functional effects of the nucleoside transport inhibitor R75231 in the ischaemic and blood reperfused rabbit heart. Cardiovascular research, 1993, Volume: 27, Issue:1 Topics: Adenine Nucleotides; Adenosine; Animals; Biological Transport, Active; Coronary Vessels; Female; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion Injury; Myocardium; Nucleosides; Piperazines; Rabbits; Regional Blood Flow; Vascular Resistance	1993
Presynaptic inhibition of norepinephrine release from sympathetic nerve endings by endogenous adenosine. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 27, Issue:4 Topics: Adenosine; Adult; Feedback; Humans; Infusions, Intra-Arterial; Male; Middle Aged; Norepinephrine; Pilot Projects; Piperazines; Presynaptic Terminals; Synaptic Transmission	1996
Modulation of atrioventricular nodal function by metabolic and allosteric regulators of endogenous adenosine in guinea pig heart. Circulation, 1996, Nov-15, Volume: 94, Issue:10 Topics: Adenosine; Allosteric Regulation; Animals; Atrioventricular Node; Biological Transport; Body Fluids; Enzyme Inhibitors; Guinea Pigs; Heart; Heart Conduction System; In Vitro Techniques; Myocardium; Nucleosides; Pericardium; Piperazines; Platelet Aggregation Inhibitors; Thiophenes; Tubercidin	1996
The implications of non-linear red blood cell partitioning for the pharmacokinetics and pharmacodynamics of the nucleoside transport inhibitor draflazine. British journal of clinical pharmacology, 1996, Volume: 42, Issue:5 Topics: Adenosine; Adult; Carrier Proteins; Erythrocytes; Humans; Male; Membrane Proteins; Nucleoside Transport Proteins; Piperazines	1996
Attenuation of ischemic liver injury by augmentation of endogenous adenosine. Transplantation, 1997, Jan-27, Volume: 63, Issue:2 Topics: Adenosine; Animals; Dogs; Female; Infusions, Intravenous; Ischemia; Lipid Peroxidation; Liver; Liver Function Tests; Malondialdehyde; Piperazines; Platelet Aggregation Inhibitors; Reperfusion Injury; Time Factors	1997
Infarct size reduction with the nucleoside transport inhibitor R-75231 in swine. The American journal of physiology, 1997, Volume: 272, Issue:4 Pt 2 Topics: Adenosine; Animals; Blood Pressure; Cardiotonic Agents; Coronary Circulation; Female; Heart Rate; Hemodynamics; Inosine; Male; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; Piperazines; Swine; Time Factors; Ventricular Function, Left	1997
Importance of endogenous adenosine during ischemia and reperfusion in neonatal porcine hearts. Circulation, 1997, Nov-04, Volume: 96, Issue:9 Topics: Adenosine; Animals; Animals, Newborn; Creatine Kinase; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Piperazines; Swine; Theophylline	1997
The A2A adenosine receptor mediates coronary vasodilation. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 284, Issue:3 Topics: Adenosine; Animals; Coronary Vessels; Female; Guinea Pigs; Male; Perfusion; Phenethylamines; Piperazines; Pyrimidines; Receptors, Purinergic P1; Triazoles; Tubercidin; Vasodilation; Xanthines	1998
Physiological red blood cell kinetic model to explain the apparent discrepancy between adenosine breakdown inhibition and nucleoside transporter occupancy of draflazine. The Journal of pharmacology and experimental therapeutics, 1998, Volume: 286, Issue:1 Topics: Adenosine; Carrier Proteins; Erythrocytes; Humans; Membrane Proteins; Models, Biological; Nucleoside Transport Proteins; Piperazines	1998
Quantification of extracellular and intracellular adenosine production: understanding the transmembranous concentration gradient. Circulation, 1999, Apr-20, Volume: 99, Issue:15 Topics: Adenine; Adenosine; Adenosine Deaminase Inhibitors; Adenosine Kinase; Animals; Biological Transport; Bradykinin; Coronary Circulation; Cytosol; Depression, Chemical; Dipyridamole; Drug Synergism; Enzyme Inhibitors; Extracellular Space; Guinea Pigs; Heart; Models, Biological; Myocardium; Osmolar Concentration; Oxygen; Oxygen Consumption; Piperazines; Thioinosine; Tubercidin	1999
The role of adenosine in insulin-induced vasodilation. Journal of cardiovascular pharmacology, 1999, Volume: 34, Issue:3 Topics: Adenosine; Adolescent; Adult; Analysis of Variance; Forearm; Humans; Insulin; Piperazines; Platelet Aggregation Inhibitors; Purinergic P1 Receptor Antagonists; Receptors, Purinergic P1; Regional Blood Flow; Theophylline; Vascular Resistance; Vasodilation; Vasodilator Agents	1999
Elevated levels of endogenous adenosine alter metabolism and enhance reduction in contractile function during low-flow ischemia: associated changes in expression of Ca(2+)-ATPase and phospholamban. Journal of molecular and cellular cardiology, 1999, Volume: 31, Issue:10 Topics: Adenosine; Animals; Calcium-Binding Proteins; Calcium-Transporting ATPases; Cardiotonic Agents; Energy Metabolism; Female; Gene Expression Regulation; Heart; In Vitro Techniques; Male; Myocardial Contraction; Myocardial Ischemia; Myocardial Reperfusion; Myocardium; Oxygen Consumption; Piperazines; Swine; Theophylline; Ventricular Function, Left	1999
The differential cardioprotective effects of nucleoside transport inhibitor on moderate and deep hypothermic ischemia with cold cardioplegia. Surgery today, 2000, Volume: 30, Issue:9 Topics: Adenine Nucleotides; Adenosine; Adenosine Triphosphate; Animals; Cold Temperature; Coronary Circulation; Drug Evaluation; Heart Arrest, Induced; In Vitro Techniques; Male; Models, Animal; Myocardial Contraction; Piperazines; Rats; Rats, Wistar	2000
Adenosine uptake inhibition ameliorates cerulein-induced acute pancreatitis in mice. Pancreas, 2002, Volume: 25, Issue:4 Topics: Acute Disease; Adenosine; Amylases; Animals; Biological Transport; Ceruletide; Dipyridamole; Female; Lipase; Mice; Mice, Inbred BALB C; Models, Chemical; Pancreatitis; Piperazines; Pyrimidinones; Quinazolines; Theophylline	2002
Mutation of Trp29 of human equilibrative nucleoside transporter 1 alters affinity for coronary vasodilator drugs and nucleoside selectivity. The Biochemical journal, 2008, Sep-01, Volume: 414, Issue:2 Topics: Adenosine; Biological Transport; Dilazep; Dipyridamole; Enzyme Activation; Equilibrative Nucleoside Transporter 1; Humans; Kinetics; Models, Biological; Mutation; Nucleosides; Piperazines; Protein Binding; Thioinosine; Tryptophan; Vasodilator Agents	2008
Cilostazol increases tissue blood flow in contracting rabbit gastrocnemius muscle. Circulation journal : official journal of the Japanese Circulation Society, 2010, Volume: 74, Issue:1 Topics: Adenosine; AMP Deaminase; Animals; Cilostazol; Dose-Response Relationship, Drug; Electric Stimulation; Male; Milrinone; Models, Animal; Muscle Contraction; Muscle, Skeletal; Phosphodiesterase 3 Inhibitors; Piperazines; Rabbits; Regional Blood Flow; Tetrazoles; Vasodilator Agents	2010