dpc-423 and apixaban

dpc-423 has been researched along with apixaban* in 1 studies

Other Studies

1 other study(ies) available for dpc-423 and apixaban

Article	Year
Phenyltriazolinones as potent factor Xa inhibitors. Bioorganic & medicinal chemistry letters, 2010, Feb-15, Volume: 20, Issue:4 We have discovered that phenyltriazolinone is a novel and potent P1 moiety for coagulation factor Xa. X-ray structures of the inhibitors with a phenyltriazolinone in the P1 position revealed that the side chain of Asp189 has reoriented resulting in a novel S1 binding pocket which is larger in size to accommodate the phenyltriazolinone P1 substrate. Topics: Anticoagulants; Crystallography, X-Ray; Drug Design; Factor Xa Inhibitors; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Pyrazoles; Pyridones; Sulfones	2010

Article

Year

Phenyltriazolinones as potent factor Xa inhibitors.

Bioorganic & medicinal chemistry letters, 2010, Feb-15, Volume: 20, Issue:4

We have discovered that phenyltriazolinone is a novel and potent P1 moiety for coagulation factor Xa. X-ray structures of the inhibitors with a phenyltriazolinone in the P1 position revealed that the side chain of Asp189 has reoriented resulting in a novel S1 binding pocket which is larger in size to accommodate the phenyltriazolinone P1 substrate.

Topics: Anticoagulants; Crystallography, X-Ray; Drug Design; Factor Xa Inhibitors; Humans; Isoxazoles; Models, Molecular; Molecular Structure; Pyrazoles; Pyridones; Sulfones

2010