Compounds > doxorubicin hydrochloride

doxorubicin hydrochloride and paclitaxel

doxorubicin hydrochloride has been researched along with paclitaxel in 29 studies

Research

Studies (29)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (6.90)29.6817
2010's21 (72.41)24.3611
2020's6 (20.69)2.80

Authors

AuthorsStudies
Ando, M; Bai, J; Bai, L; Bai, Y; Deng, Q; Hasegawa, T; Hirose, K; Kataoka, T; Koyanagi, R; Nagai, K; Sakai, J; Tsukumo, Y; Wang, J; Wang, L; Xing, F; Xue, H; Zhang, S; Zhao, M1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Prinz, H; Schmidt, P; Unger, E; Zuse, A1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Agrawal, SK; Rani, R; Roy, P; Saxena, AK; Singh, J; Sondhi, SM1
Baasner, S; Böhm, KJ; Gerlach, M; Günther, EG; Müller, K; Nickel, HC; Prinz, H; Schmidt, P; Unger, E1
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ1
Cao, R; Chen, Z; Peng, W; Ren, Z; Shi, B; Song, H; Yi, W; Yu, L1
Ekins, S; Williams, AJ; Xu, JJ1
Cao, R; Chen, Z; Fan, W; Guo, L; Ma, Q; Shi, B; Song, H; Sun, J1
Batista-Gonzalez, A; Brunhofer, G; Fallarero, A; Gopi Mohan, C; Karlsson, D; Shinde, P; Vuorela, P1
Bedi, PM; Budhiraja, A; Gupta, MK; Kaur, C; Nepali, K; Saxena, AK; Sharma, S1
Cao, D; Chen, L; Li, L; Liu, L; Ma, L; Tang, M; Wang, F; Wang, G; Wang, J; Wen, J; Wu, W; Xiang, M; Xiang, W; Yang, J; Yang, Z; You, J; Zhang, R; Zhu, J1
Guo, YX; Hu, XY; Kang, YQ; Lee, KH; Li, RJ; Lin, ZM; Lou, HX; Morris-Natschke, SL; Wang, S; Wu, JY; Yuan, HQ; Zhang, JZ; Zhou, JC; Zhu, RX1
Bi, C; Fu, H; Li, Y; Shao, R; Song, D; Su, F; Tang, S; Wang, S; Zhang, C1
Bai, P; Cao, D; Chen, L; Lei, L; Liu, Y; Ma, B; Ma, L; Tang, M; Wang, C; Wang, F; Wang, T; Wang, X; Xu, B; Yan, W; Yang, T; Yang, Z; Zhou, Y1
Hu, QW; Li, L; Lou, HX; Niu, HM; Sun, B; Xie, F; Yuan, HQ; Zheng, HB1
Hu, QW; Li, L; Lou, HX; Niu, HM; Sun, B; Tang, H; Yuan, HQ; Zheng, HB1
Cao, D; Chen, L; Chen, Y; He, L; Li, D; Shao, M; Shen, M; Wang, F; Wang, T; Yan, W; Yang, Z; Zhou, Y1
Cho, WJ; Han, J; Jin, Y; Khadka, DB; Kwon, Y; Park, S1
Bai, C; Chen, J; Chen, Y; Chong, C; Ding, Y; Gao, Y; Geng, Y; Li, J; Wang, M; Wu, L; Yu, J; Zhang, Q1
Bai, P; Chen, L; Hu, M; Li, Y; Tang, M; Yan, W; Yang, J; Yang, Z1
Bi, Y; Li, W; Ma, C; Shuai, W; Sun, H; Xu, F; Xu, J; Xu, S; Yao, H; Zhu, Z1
Dong, JY; Huang, G; Li, SS; Meng, QQ; Zhang, QJ; Zhao, HR; Zhu, BQ1
Ji, A; Li, L; Li, X; Liu, J; Liu, Z; Lou, H; Qian, L; Qiao, Y; Sun, Y; Wang, X; Xu, Y; Zhao, X1
Chen, ZS; Li, W; Liu, Y; Shuai, W; Tan, Y; Xu, J; Xu, S; Yang, DH; Yang, L; Yao, H; Zheng, T; Zhu, H; Zhu, Z1
Han, L; Huang, X; Jin, X; Li, X; Liang, B; Ouyang, F; Xu, Y; Yan, J; Zhan, M; Zhang, Q1
Bai, P; Chen, L; Fu, S; Han, K; He, W; Li, J; Li, Y; Liu, J; Liu, Y; Shi, M; Tang, M; Xie, L; Yan, W; Yang, J; Yang, Z; Ye, H; Zhang, C; Zhu, Z1
Cai, Z; Ghaleb, H; Huang, W; Jiang, Y; Liu, Y; Qian, H; Qiu, Q; Shi, W; Yin, Z; Zhang, P; Zhou, J; Zou, F1
Li, X; Lin, H; OuYang, F; Pang, Y; Yan, J; Zhang, W; Zhou, J1

Other Studies

29 other study(ies) available for doxorubicin hydrochloride and paclitaxel

ArticleYear
Bioactive guaianolides from siyekucai (Ixeris chinensis).
    Journal of natural products, 2006, Volume: 69, Issue:10

    Topics: Antineoplastic Agents, Phytogenic; Asteraceae; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Humans; Inhibitory Concentration 50; Intercellular Adhesion Molecule-1; Molecular Structure; Plants, Medicinal; Sesquiterpenes, Guaiane; Tumor Cells, Cultured

2006
Sulfonate derivatives of naphtho[2,3-b]thiophen-4(9H)-one and 9(10H)-anthracenone as highly active antimicrotubule agents. Synthesis, antiproliferative activity, and inhibition of tubulin polymerization.
    Journal of medicinal chemistry, 2007, Nov-29, Volume: 50, Issue:24

    Topics: Anthracenes; Cell Cycle; Cell Line, Tumor; Colchicine; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthalenes; Nocodazole; Podophyllotoxin; Structure-Activity Relationship; Thiophenes; Tubulin; Tubulin Modulators

2007
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Solvent free synthesis, anti-inflammatory and anticancer activity evaluation of tricyclic and tetracyclic benzimidazole derivatives.
    Bioorganic & medicinal chemistry letters, 2010, Apr-01, Volume: 20, Issue:7

    Topics: Anti-Inflammatory Agents; Antineoplastic Agents; Benzimidazoles; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Microwaves; Neoplasms; Ovarian Neoplasms

2010
Synthesis, antiproliferative activity and inhibition of tubulin polymerization by 1,5- and 1,8-disubstituted 10H-anthracen-9-ones bearing a 10-benzylidene or 10-(2-oxo-2-phenylethylidene) moiety.
    European journal of medicinal chemistry, 2010, Volume: 45, Issue:8

    Topics: Anthracenes; Antineoplastic Agents; Benzylidene Compounds; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Humans; Protein Multimerization; Protein Structure, Quaternary; Tubulin

2010
Developing structure-activity relationships for the prediction of hepatotoxicity.
    Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes

2010
Synthesis of novel beta-carbolines with efficient DNA-binding capacity and potent cytotoxicity.
    Bioorganic & medicinal chemistry letters, 2010, Jul-01, Volume: 20, Issue:13

    Topics: Animals; Antineoplastic Agents; Binding Sites; Carbolines; Cattle; Cell Line, Tumor; Cell Proliferation; DNA; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Molecular Structure; Solubility; Stereoisomerism; Structure-Activity Relationship

2010
A predictive ligand-based Bayesian model for human drug-induced liver injury.
    Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12

    Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands

2010
Synthesis and biological evaluation of 1,9-disubstituted β-carbolines as potent DNA intercalating and cytotoxic agents.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:10

    Topics: Antineoplastic Agents; Carbolines; Cell Line, Tumor; Cytotoxins; DNA; Drug Screening Assays, Antitumor; Humans; Inhibitory Concentration 50; Intercalating Agents; Neoplasms

2011
Exploration of natural compounds as sources of new bifunctional scaffolds targeting cholinesterases and beta amyloid aggregation: the case of chelerythrine.
    Bioorganic & medicinal chemistry, 2012, Nov-15, Volume: 20, Issue:22

    Topics: Acetylcholinesterase; Amyloid beta-Peptides; Benzophenanthridines; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Humans; Isoquinolines; Kinetics; Molecular Docking Simulation; Structure-Activity Relationship

2012
Chalcone based azacarboline analogues as novel antitubulin agents: design, synthesis, biological evaluation and molecular modelling studies.
    European journal of medicinal chemistry, 2014, Oct-06, Volume: 85

    Topics: Antineoplastic Agents; Carbolines; Cell Line, Tumor; Chalcone; Chemistry Techniques, Synthetic; Drug Design; Humans; Models, Molecular; Molecular Conformation; Structure-Activity Relationship; Tubulin Modulators

2014
Synthesis and biological evaluation of novel millepachine derivatives as a new class of tubulin polymerization inhibitors.
    Journal of medicinal chemistry, 2014, Oct-09, Volume: 57, Issue:19

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcones; Drug Resistance, Multiple; Fluorescent Antibody Technique; Hep G2 Cells; Humans; Mice, Inbred BALB C; Structure-Activity Relationship; Tubulin Modulators; Xenograft Model Antitumor Assays

2014
Notolutesins A-J, dolabrane-type diterpenoids from the Chinese liverwort Notoscyphus lutescens.
    Journal of natural products, 2014, Sep-26, Volume: 77, Issue:9

    Topics: Antineoplastic Agents, Phytogenic; Circular Dichroism; Crystallography, X-Ray; Diterpenes; Drug Screening Assays, Antitumor; Drugs, Chinese Herbal; Hepatophyta; Humans; Inhibitory Concentration 50; Male; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular

2014
Synthesis and biological evaluation of sophoridinol derivatives as a novel family of potential anticancer agents.
    ACS medicinal chemistry letters, 2014, Nov-13, Volume: 5, Issue:11

    Topics:

2014
Design, Synthesis, and Evaluation of in Vitro and in Vivo Anticancer Activity of 4-Substituted Coumarins: A Novel Class of Potent Tubulin Polymerization Inhibitors.
    Journal of medicinal chemistry, 2016, 06-23, Volume: 59, Issue:12

    Topics: Animals; Antineoplastic Agents; Cell Proliferation; Coumarins; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Human Umbilical Vein Endothelial Cells; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Polymerization; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Tumor Cells, Cultured; Wound Healing

2016
Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors.
    European journal of medicinal chemistry, 2016, Oct-04, Volume: 121

    Topics: Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chemistry Techniques, Synthetic; Drug Design; Humans; Macrocyclic Compounds; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Quaternary; Structure-Activity Relationship; Tubulin Modulators

2016
Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents.
    European journal of medicinal chemistry, 2017, Mar-31, Volume: 129

    Topics: Antineoplastic Agents; Bibenzyls; Cell Line, Tumor; Cell Proliferation; Drug Design; Humans; Macrocyclic Compounds; Models, Molecular; Molecular Docking Simulation; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2017
Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents.
    European journal of medicinal chemistry, 2017, Sep-29, Volume: 138

    Topics: Aniline Compounds; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Molecular Structure; Polymerization; Quinolines; Structure-Activity Relationship; Tubulin

2017
Design, synthesis, and biological evaluation of 1,3-diarylisoquinolines as novel topoisomerase I catalytic inhibitors.
    European journal of medicinal chemistry, 2018, Jan-01, Volume: 143

    Topics: Antineoplastic Agents; Biocatalysis; Cell Line, Tumor; Cell Proliferation; DNA Topoisomerases, Type I; Dose-Response Relationship, Drug; Drug Design; Drug Screening Assays, Antitumor; Humans; Isoquinolines; Molecular Structure; Polymerization; Structure-Activity Relationship; Topoisomerase I Inhibitors; Tubulin

2018
Syntheses and anti-pancreatic cancer activities of rakicidin A analogues.
    European journal of medicinal chemistry, 2018, May-10, Volume: 151

    Topics: Adenocarcinoma; Antineoplastic Agents; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Combinatorial Chemistry Techniques; Humans; Lipopeptides; Neoplastic Stem Cells; Pancreatic Neoplasms; Peptides, Cyclic; Structure-Activity Relationship; Tumor Hypoxia

2018
Discovery of novel β-carboline/acylhydrazone hybrids as potent antitumor agents and overcome drug resistance.
    European journal of medicinal chemistry, 2018, May-25, Volume: 152

    Topics: Animals; Antineoplastic Agents; Carbolines; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Drug Discovery; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Female; Humans; Hydrazones; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms, Experimental; Structure-Activity Relationship

2018
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
    European journal of medicinal chemistry, 2019, Feb-01, Volume: 163

    Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Line, Tumor; Colchicine; Drug Design; Drug Screening Assays, Antitumor; Heterografts; Humans; Indoles; K562 Cells; Neoplasms; Quinolines; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2019
Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents.
    European journal of medicinal chemistry, 2019, Mar-01, Volume: 165

    Topics: Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Drug Screening Assays, Antitumor; Humans; Naphthoquinones; Oximes; Structure-Activity Relationship; Sulfur

2019
Discovery of lysosome-targeted covalent anticancer agents based on isosteviol skeleton.
    European journal of medicinal chemistry, 2021, Jan-01, Volume: 209

    Topics: A549 Cells; Antineoplastic Agents; Cell Death; Diterpenes, Kaurane; Drug Design; Humans; Lysosomes; Neoplasms

2021
Discovery of novel N-benzylbenzamide derivatives as tubulin polymerization inhibitors with potent antitumor activities.
    European journal of medicinal chemistry, 2021, Apr-15, Volume: 216

    Topics: Animals; Antineoplastic Agents; Apoptosis; Benzamides; Binding Sites; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Colchicine; Drug Design; Drug Screening Assays, Antitumor; Humans; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Neoplasms; Neovascularization, Physiologic; Structure-Activity Relationship; Tubulin; Tubulin Modulators

2021
Structure modification and biological evaluation of indole-chalcone derivatives as anti-tumor agents through dual targeting tubulin and TrxR.
    European journal of medicinal chemistry, 2022, Jan-05, Volume: 227

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Chalcones; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Humans; Indoles; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Structure-Activity Relationship; Thioredoxin-Disulfide Reductase; Tubulin; Tubulin Modulators

2022
Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.
    Journal of medicinal chemistry, 2022, 02-10, Volume: 65, Issue:3

    Topics: Animals; Antineoplastic Agents; Apoptosis; Binding Sites; Carbolines; Cell Line, Tumor; Cell Proliferation; Drug Design; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Female; G2 Phase Cell Cycle Checkpoints; Humans; Mice, Inbred BALB C; Mice, Nude; Molecular Structure; Neoplasms; Protein Binding; Rats; Structure-Activity Relationship; Tubulin; Tubulin Modulators; Xenograft Model Antitumor Assays

2022
Exploration of novel phthalazinone derivatives as potential efflux transporter inhibitors for reversing multidrug resistance and improving the oral absorption of paclitaxel.
    European journal of medicinal chemistry, 2022, Apr-05, Volume: 233

    Topics: ATP Binding Cassette Transporter, Subfamily G, Member 2; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Humans; Neoplasm Proteins; Neoplasms; Paclitaxel

2022
Discovery of a Novel Stilbene Derivative as a Microtubule Targeting Agent Capable of Inducing Cell Ferroptosis.
    Journal of medicinal chemistry, 2022, 03-24, Volume: 65, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Ferroptosis; Humans; Microtubules; Neoplasms; Stilbenes

2022