doxifluridine has been researched along with floxuridine in 672 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 131 (19.49) | 18.7374 |
| 1990's | 229 (34.08) | 18.2507 |
| 2000's | 240 (35.71) | 29.6817 |
| 2010's | 67 (9.97) | 24.3611 |
| 2020's | 5 (0.74) | 2.80 |
| Authors | Studies |
|---|---|
| Cook, AF; Holman, MJ; Kramer, MJ; Trown, PW | 1 |
| González-Díaz, H; Orallo, F; Quezada, E; Santana, L; Uriarte, E; Viña, D; Yáñez, M | 1 |
| Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A | 1 |
| Araki, H; Hashimoto, T; Kodama, M; Yasui, K; Yoshioka, T | 1 |
| Yuan, H; Zhang, Z | 1 |
| Inaji, H; Miura, S; Morimoto, K; Ohta, J; Taguchi, T; Ueda, N; Yayoi, K | 1 |
| Hashimoto, M; Hosoda, Y; Katai, H; Koh, J; Maeda, K; Murayama, Y; Sakai, S; Sano, M; Yamamoto, O | 1 |
| Itoh, N; Kurimoto, N; Tamura, T; Yasuzawa, Y; Yoshimoto, I | 1 |
| Irie, K; Kawahara, T; Okumura, T; Ota, J; Sakai, K; Shimoyama, T; Taguchi, T; Terasawa, T; Yamamoto, M; Yasutake, K | 1 |
| Furuya, K; Kashu, Y; Kiyasu, Y; Moriuchi, A; Sakai, K; Satoh, H; Shigematsu, S; Tanaka, T | 1 |
| Araya, S; Fukumoto, M; Hayashi, H; Kawabata, K; Kimura, H; Masai, Y; Meyer, C; Nio, Y; Tseng, CC; Tsubono, M | 1 |
| Kato, M; Minato, H; Noguchi, A; Sawai, K; Takahashi, T | 1 |
| Bajetta, E; Colleoni, M; de Braud, F; Nelli, P; Nolè, F; Zilembo, N | 1 |
| Katoh, T; Kawahara, T; Kobayakawa, K; Takatsuka, Y; Tsumura, I | 1 |
| Cloos, J; Noordhuis, P; Peters, GJ; Pinedo, HM; Smid, K; van der Wilt, CL | 1 |
| Fujimura, N; Ishida, C; Koyama, S; Maezato, K; Makino, N; Matsukawa, Y; Matsumoto, K; Mizuno, Y; Naitoh, M; Yamamoto, E | 1 |
| Aikawa, T; Hirai, T; Kotsuma, Y; Maeura, Y; Miyauchi, K; Takatsuka, Y; Yayoi, E | 1 |
| Ebata, K; Endo, M; Horiuchi, J; Kamata, R; Saito, T; Sanuki, E; Sato, K; Sekiguchi, K; Shibuya, H; Yamashita, T | 1 |
| Eliason, JF; Givel, JC; Laurent, PL; Odartchenko, N; Suardet, L; Tevaearai, HT | 1 |
| Ikeda, M; Noda, K; Ochiai, K; Saito, Y; Sato, A; Suzuki, M; Takada, M; Terashima, Y; Yajima, A; Yoshida, K | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Tanaka, T; Tanaka, Y | 1 |
| Senderoff, RI; Smith, DR; Sokoloski, TD; Weber, PA | 1 |
| Ohtagaki, S; Toge, T; Toi, M; Yagi, M; Yoshinaka, K | 1 |
| de Bruijn, EA; Geng, Y; Gheuens, E | 1 |
| Fukuda, S; Iwasaki, Y; Kawai, Y; Miyamoto, H; Nozue, M; Todoroki, T; Ueda, H | 1 |
| Maeda, H; Miyamoto, T; Mochinaga, N; Tsunoda, T | 1 |
| Fujimaki, M; Kurokawa, M; Kuroki, Y; Ochiai, H; Okamoto, M; Tazawa, K; Yamashita, I | 1 |
| Neijt, JP; ten Bokkel Huinink, WW; van der Burg, ME; van Oosterom, AT; Vermorken, JB; Willemse, PH | 1 |
| Adachi, S; Akaza, H; Ishitsuka, H; Kanazawa, K; Miwa, M; Nitta, K; Sekiguchi, F; Tokita, H | 1 |
| Calabresi, F; Repetto, M | 1 |
| Ido, T; Ishiwata, K; Kameyama, M; Sato, K; Yoshimoto, T | 1 |
| Fukuoka, H; Fukushima, S; Hosaka, M; Kinoshita, Y; Kondo, I; Kubota, Y; Miura, T; Miyai, K; Moriyama, M; Shuin, T | 1 |
| Akebi, N; Josen, T; Kobashi, K; Matsumura, Y; Nanba, K; Nasu, Y; Ochi, J; Ohmori, H; Saika, T; Tanahashi, T | 1 |
| Kawahara, T; Kikkawa, N; Kobayakawa, K; Tsuchiya, Y; Tsumura, I | 1 |
| Eda, H; Ishitsuka, H; Tanaka, Y | 1 |
| Hasegawa, K; Ikeda, M; Kinugasa, M; Kobashi, Y; Noda, K; Odagiri, H; Ohiwa, T; Sekiba, K; Takeuchi, K; Watanabe, Y | 1 |
| Akazai, Y; Fuchimoto, S; Iwagaki, H; Matsubara, N; Orita, K; Shiiki, S; Watanabe, T | 1 |
| Bishop, JF; Guentert, TW; Hill, HS; Hillcoat, BL; Morris, RG; Olver, IN; Reece, PA | 1 |
| Griffiths, JR; Maxwell, RJ; Prior, MJ | 1 |
| Eda, H; Fujimoto, K; Ishida, M; Ishitsuka, H; Miwa, M; Ninomiya, Y; Sahara, H; Umeda, I; Yokose, K | 1 |
| Harada, T; Hirano, M; Kikkawa, H; Masuda, S; Matsu, T; Saito, H; Sakatoku, M; Tatsuzawa, T | 1 |
| Alberto, P; Mermillod, B; Winkelmann, JJ | 1 |
| Hiromoto, M; Kobayashi, K; Kumagai, K; Masuo, K; Nakayama, A; Nishida, Y; Sanada, Y; Yasui, A | 1 |
| Imai, S; Morimoto, H; Nio, Y; Shiraishi, T; Tobe, T; Tseng, CC; Tsubono, M | 1 |
| Imaoka, S; Inaji, H; Iwanaga, T; Koyama, H; Miyauchi, K; Nishizawa, Y; Noguchi, S; Yamamoto, H | 1 |
| De Clercq, E; Iigo, M; Miwa, M | 1 |
| Aikawa, T; Hirai, T; Kaji, M; Kitada, M; Kotsuma, Y; Maeura, Y; Miyauchi, K; Satomi, T; Takatsuka, Y; Yayoi, E | 1 |
| Bishop, JF; Guentert, TW; Hillcoat, BL; Morris, RG; Olver, IN; Reece, PA | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Miwa, M; Ninomiya, Y; Ryu, M; Umeda, I; Yokose, K | 1 |
| Izumi, T; Kumagai, K; Kurihara, M; Masuo, K; Nishida, Y; Sanada, Y; Yasui, A | 1 |
| Arima, S; Fukamura, T; Haruta, J; Hashimoto, M; Jyozaki, H; Okamoto, K; Shimura, H; Umeno, T | 1 |
| Kaneda, T; Kasuya, Y; Matsuyama, M; Shinoda, T; Tohnai, I; Zhao, L | 1 |
| Fukuda, H; Kitahara, T; Nagamine, H; Nakaguchi, K; Nakano, Y; Onoe, K | 1 |
| Majima, H; Mayama, M; Oguro, M; Wakatsuki, S; Watanabe, S | 1 |
| Inaba, M; Mitsuhashi, J; Ozawa, S | 1 |
| Adachi, I; Douden, K; Hayashi, H; Hikishima, H; Iwa, T; Munemoto, Y; Okada, Y; Omura, K; Watanabe, Y | 1 |
| Kawada, S; Kondo, H; Ootani, I; Sato, T; Shibata, T; Suzuki, H | 1 |
| Kumar, AM; Nayak, R | 1 |
| Fukushima, T; Hara, Y; Hashimoto, T; Hirakawa, T; Kono, A; Tanaka, M; Tomonaga, M; Yamashita, M | 1 |
| Nakagawa, Y | 1 |
| Laurensse, E; Leyva, A; Peters, GJ; Pinedo, HM | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH; Tan, YY | 1 |
| Tsukagoshi, S | 3 |
| Ando, J; Kosaka, A; Sumiyoshi, K | 1 |
| Braakhuis, BJ; de Bruijn, EA; Laurensse, EJ; Peters, GJ; Pinedo, HM; van Walsum, M | 1 |
| Araki, E; Hoshi, A; Iigo, M; Nakajima, Y | 1 |
| Baba, T; Furukohri, N; Itoh, T; Munakata, A; Ogasawara, H; Saitoh, S; Sakata, Y; Tamura, Y; Tsushima, K; Yoshida, Y | 1 |
| Alberto, P; Bruyere, A; Decoster, G; Holdener, EE; Paschoud, N; Peytremann, R; Righetti, A; Winkelmann, JJ | 1 |
| De Clercq, E; Hoshi, A; Iigo, M; Nakajima, Y; Nishikata, K; Odagiri, H; Okudaira, N | 1 |
| Au, JL; Bramer, SL; Gunnarsson, LC | 1 |
| Au, JL; Gunnarsson, LC | 1 |
| Imamura, Y; Matsusita, K; Okutani, T; Ono, S; Oya, M; Tokisue, M; Yasutake, K; Yoshimura, Y | 1 |
| Ishikawa, T; Ishitsuka, H; Ohkawa, T; Tanaka, Y | 1 |
| Baba, K; Kawano, H; Matsuda, M; Matsuoka, Y; Morinaga, H; Nagao, K; Nagase, H; Nishimura, R; Ueno, Y | 1 |
| Decoster, G; Heim, ME; Queisser, W; Schuster, D | 1 |
| Braakhuis, BJ; Laurensse, EJ; Peters, GJ; Pinedo, HM | 1 |
| Enomoto, T; Watanabe, A | 1 |
| Calcanis, A; Drings, P | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Kawata, S; Miyazaki, M; Ohta, M; Shimura, T; Shrestha, RD; Sugasawa, H; Takahashi, O | 1 |
| Furue, H; Kanamaru, R; Kimura, K; Komita, T; Murakami, M; Nakao, I; Ohta, K; Saito, T; Wakui, A; Yokoyama, M | 1 |
| Abe, O; Kimura, K; Kimura, T; Kurihara, M; Nakao, I; Niitani, H; Ohta, K; Saito, T; Urushizaki, I; Yoshida, Y | 1 |
| Abe, O; Ogawa, N; Taguchi, T; Terasawa, T; Tominaga, T; Yoshida, Y | 1 |
| de Bruijn, EA; Pinedo, HM; Reeuwijk, HJ; Tjaden, UR; van Oosterom, AT | 1 |
| Edwards, IR; Ferry, DG; Hung, CT; Perrier, DG; Schaaf, LJ | 1 |
| Hayashi, K; Kitamura, M; Kosaki, G; Takahashi, I; Tominaga, T | 1 |
| Irie, K; Kawahara, T; Okajima, K; Sakai, K; Satomi, T; Taguchi, T; Terasawa, T; Tomita, K; Yamaguchi, A; Yamamoto, M | 1 |
| Amano, R; Hujii, Y; Ishida, T; Iwamoto, K; Komuro, K; Mitsumori, N; Murai, R; Nagasaki, Y; Nagayama, A; Yamazaki, M | 1 |
| Alberto, P; Bruntsch, U; Cavalli, F; Clavel, M; Gundersen, S; Pinedo, H; Renard, J; Rozencweig, M; Siegenthaler, P | 1 |
| Okumura, T | 1 |
| Imamura, Y; Irie, K; Nakamura, T; Suehiro, I; Yasutake, K; Yoshida, M; Yoshimura, Y | 1 |
| Baba, H; Kunimoto, T; Nitta, K; Sasaki, T; Takeuchi, M; Tanaka, T; Uehara, N | 1 |
| Armand, JP; Bernadou, J; Béteille, JP; Bon, M; Lopez, A; Malet-Martino, MC; Martino, R | 3 |
| Hoshino, A; Kamiya, O; Kawakubo, A; Nagata, K; Ogasawara, T; Ohara, K; Ono, Y; Ozaki, Y; Sugiura, I; Suzuki, A | 1 |
| Armstrong, RD; Cadman, EC; Takimoto, CH | 1 |
| Endoh, F; Fujimoto, S; Igarashi, K; Miyazaki, M; Ohta, M; Okui, K; Shrestha, RD; Togawa, Y | 1 |
| Fosså, SD; Heier, MS | 2 |
| Armand, JP; Bastit, P; Cappelaere, P; Fargeot, P; Fumoleau, P; Hurteloup, P; Keiling, R; Kerbrat, P; Metz, R; Schraub, S | 1 |
| Hara, Y; Karube, Y; Kono, A; Matsushima, Y; Sugata, S | 1 |
| Faure, F; Hollande, E; Malet-Martino, MC; Martino, R; Palevody, C; Vialaneix, JP | 1 |
| Hachisuka, K; Hiraiwa, K; Hoshino, A; Kamiya, O; Kinoshita, T; Murakami, M; Ota, K; Yamada, M; Yamaguchi, A; Yasue, M | 1 |
| Lankelma, J; Laurensse, EJ; Leyva, A; Peters, GJ; Pinedo, HM; van Dijk, J; van Groeningen, C | 1 |
| Fujita, F; Fujita, M; Shimozuma, K; Taguchi, T | 1 |
| Kurihara, M; Taguchi, S | 1 |
| Fosså, SD; Heier, MS; Heintz, R | 1 |
| Aas, M; Flokkmann, A; Fosså, SD; Heier, M; Heintz, R; Linder-Ciccolunghi, S; Moe, B | 1 |
| Au, JL; Canobbio, L; Rustum, YM; Trave, F | 1 |
| Fujita, F; Fujita, M; Hirai, T; Taguchi, T | 1 |
| Cook, A; Ishitsuka, H; Miwa, M | 1 |
| Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T | 1 |
| Fujita, F; Fujita, M; Inaba, H; Sakamoto, Y; Shimozuma, K; Taguchi, T; Yamauchi, T | 1 |
| Berger, MR; Garzon, FT; Keppler, BK; Schmähl, D | 1 |
| Taguchi, T | 3 |
| Armand, JP; Bernadou, J; Malet-Martino, MC; Martino, R; Roché, H | 1 |
| Akwari, OE; Goodwin, BJ; Neuss, MN; Stevenson, DF | 1 |
| Berg-Johnsen, J; Heier, MS; Langmoen, IA | 1 |
| Ishitsuka, H; Kamiyama, T; Miwa, M; Nishimura, J | 1 |
| Armand, JP; Bernadou, J; Malet-Martino, MC; Martino, R; Servin, P | 1 |
| Fujimoto, S; Ogawa, M; Wang, Y | 1 |
| Eda, H; Fukuda, H; Ishikawa, T; Ishitsuka, H; Matsuura, N; Miwa, M; Ninomiya, Y; Tanaka, Y | 1 |
| Hasegawa, K; Hatta, Y; Kawachi, M; Kurihara, M; Niitani, H; Suwa, T; Taguchi, S; Tsuboi, E; Yasui, A; Yoshimori, K | 1 |
| Fujimoto, K; Ishitsuka, H; Matsuura, N; Miwa, M; Ninomiya, Y; Ryu, M | 1 |
| Eda, H; Fujimoto, K; Fukuda, H; Ishitsuka, H; Miwa, M | 1 |
| Alberto, P; Cavalli, F; Germano, G; Joss, R; Kaplan, S; Martz, G; Mermillod, B; Spati, B; Weber, W | 1 |
| Alberto, P; Cavalli, F; Decoster, G; Jungi, WF; Mermillod, B; Obrecht, JP; Siegenthaler, P | 1 |
| Alley, PA; Choong, YS; Lee, SP | 1 |
| Au, JL; Bramer, SL; Wientjes, MG | 1 |
| Ichihara, S; Kuruma, I; Odagiri, H; Semura, E; Tateishi, M; Utoh, M | 1 |
| Komaki, K; Konishi, Y; Miki, H; Monden, Y; Morimoto, T; Ooshimo, K; Tanaka, T; Uomine, Y; Yamakawa, T | 1 |
| Almersjö, O; Berne, M; Gustavsson, B; Spears, P; Sundström, E | 1 |
| Dobbs, BR; Edwards, IR; Perrier, DG; Schaaf, LJ | 2 |
| Hattori, T; Hirabayashi, N; Kirihara, Y; Niimoto, M; Nishiyama, M; Nosoh, Y; Saeki, T; Takagami, S | 1 |
| Au, JL; Wientjes, MG | 1 |
| Gocho, Y; Ishitani, K; Kogo, Y; Kouda, K; Koyama, R; Matsuda, M; Nagai, T; Niitsu, Y; Saijo, N; Urushizaki, I | 1 |
| Bernheim, JL; De Dobbeleer, GB; Roobol, C | 1 |
| Chiang, TT; Lai, KH; Lay, CS; Lee, SD; Ng, WW; Tsai, YT; Wang, JY; Wang, SS; Yang, CF; Yeh, YS | 1 |
| Iigo, M; Ishitsuka, H; Miwa, M; Nitta, K | 1 |
| Iwao, N; Koda, T; Kurahori, T; Miyaji, J; Okahisa, N; Sonoda, T; Sumi, S; Yanagimoto, H | 1 |
| Hoshi, A; Iigo, M; Nishimura, S; Yamaizumi, Z | 1 |
| Aoyama, A; Hirata, K; Niitani, H; Ootsuka, M; Shibuya, M; Shimabukuro, Z; Yano, T | 1 |
| Choong, YS; Lee, SP | 1 |
| Fujimoto, S; Inoue, K; Ogawa, M; Wang, Y | 1 |
| Fujita, M; Nakano, Y; Ohota, J; Taguchi, T | 1 |
| Creaven, PJ; Madajewicz, S; Mittelman, A | 1 |
| Shibui, S | 1 |
| Hartmann, HR; Matter, A | 1 |
| Ishitsuka, H; Miwa, M; Nakamura, J | 1 |
| Au, JL; Luccioni, CM; Rustum, YM; Wientjes, MG | 1 |
| Abele, R; Alberto, P; Bollag, W; Germano, G; Heintz, R; Seematter, RJ | 1 |
| Cadman, E; Grant, S | 1 |
| Aubert, C; Cano, JP; Coassolo, P; Rigault, JP; Sommadossi, JP | 1 |
| Carter, GL; Cory, JG | 1 |
| Isobe, K; Iwase, H; Kimura, K; Kuwabara, T; Sato, A; Suga, S; Takada, T; Yokoyama, Y; Yoshida, Y | 1 |
| Aubert, C; Cano, JP; Gouveia, J; Mathé, G; Ribaud, P; Sommadossi, JP | 1 |
| Au, JL; Minowada, J; Rustum, YM; Srivastava, BI | 1 |
| Armstrong, RD; Cadman, E | 1 |
| Armstrong, RD; Connolly, KM; Diasio, RB; Kaplan, AM | 1 |
| Hara, Y; Ishitsuka, H; Karube, Y; Kono, A; Matsushima, Y; Sugata, S | 1 |
| Armstrong, RD; Cadman, E; Gesmonde, J; Wu, T | 1 |
| Kimura, K; Suga, S | 1 |
| Doi, Y; Fujita, H; Kawaguchi, K; Nakagawa, H; Nakagawa, Y; Ogawa, K | 1 |
| Armstrong, RD; Cadman, E; Connolly, KM; Kaplan, AM | 1 |
| Almersjö, O; Berne, M; Gastavsson, B; Waldenström, J | 1 |
| Miki, Y; Miwa, M; Nomura, K; Shibui, S; Watanabe, T | 1 |
| Abele, R; Alberto, P; Cavalli, F; Hartmann, D; Hofmann, V; Holdener, EE; Kaplan, S; Ryssel, HJ; Siegenthaler, P | 1 |
| Abele, R; Cavalli, F; Grossenbacher, R; Kaplan, E; Schmid, HJ | 1 |
| Bollag, W; Hartmann, HR | 2 |
| Imai, S; Nakazawa, M; Tamatsu, H; Watari, H | 1 |
| Fujita, F; Fujita, M; Taguchi, T | 1 |
| Hara, Y | 1 |
| Hara, Y; Kono, A; Tanaka, M | 1 |
| Fujii, S; Shirasaka, T | 1 |
| Cooper, AJ; Goeting, N; Morgan, GR; Taylor, I; Trotter, GA | 1 |
| Eguchi, K; Fujita, J; Hoshi, A; Nomori, H; Saijo, N; Sasaki, Y; Shimizu, E; Shinkai, T; Tominaga, K | 1 |
| Armstrong, RD; Diasio, RB | 1 |
| Chandler, WF; Doan, KM; Ensminger, WD; Greenberg, HS; Gyves, JW; Kindt, GW; Phillips, TW; Seeger, JF | 1 |
| Fukuoka, K; Ishitsuka, H; Itoga, A; Maruyama, HB; Miwa, M; Takemoto, K | 1 |
| Ishitsuka, H; Kitta, K; Ohta, Y; Sueki, K; Takemoto, K; Yagi, Y | 1 |
| Fukazawa, H; Hongu, Y; Ichihara, S; Shimizu, H; Suzuki, S | 1 |
| Cano, JP; Sommadossi, JP | 1 |
| Fujioka, A; Nakano, K; Okabe, H; Saito, H; Takeda, S; Toko, T; Unemi, N | 1 |
| Inaba, M; Ohnishi, Y; Sato, S; Tashiro, T; Yamori, T; Yoshimura, M | 1 |
| Fujimura, T; Gotoh, K; Ishida, Y; Maeura, Y; Matsunaga, S; Miyazaki, H; Munetomo, Y; Nakata, E; Okajima, K; Toyohara, M | 1 |
| Bajetta, E; Bozzetti, F; Buzzoni, R; Cappuzzo, F; Colleoni, M; Di Bartolomeo, M; Doci, R; Guenzi, A; Somma, L; Stampino, CG | 1 |
| Iida, T; Kimura, T; Kitamura, H; Kobayashi, T; Matsumoto, Y; Murohisa, B; Nagashima, T; Nakaya, Y; Shibata, M; Uchimura, M | 1 |
| Adachi, H; Kobori, O; Kurihara, M; Kurihara, T; Murakami, H; Saito, K; Tamura, Y | 1 |
| Cao, S; Durrani, FA; Mayhew, EG; Peters, GJ; Rustum, YM; Van Laar, JA | 1 |
| Ishikawa, S; Katsube, T; Konno, S; Miura, K; Naritaka, Y; Ogawa, K; Shimakawa, T; Wagatsuma, Y; Wakasugi, S; Watanabe, T | 1 |
| Ishihata, R; Kasukawa, R; Kuwana, T; Nishimaki, T; Obara, K | 1 |
| Bicknell, R; Harris, AL; Moghaddam, A; Patterson, AV; Stratford, IJ; Talbot, DC; Zhang, H | 1 |
| Urushizaki, I | 1 |
| Akiyama, S; Furukawa, T; Haraguchi, M; Sumizawa, T | 1 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Nakano, M; Saneyoshi, M | 1 |
| Hayashi, K; Taniguchi, T; Toi, M; Tominaga, T | 1 |
| Ishikawa, T; Ishitsuka, H; Tanaka, Y; Ura, M; Yamamoto, T | 1 |
| Fujimoto, T; Iihara, K; Kitada, M; Murotani, M; Okumura, Y; Shibata, T; Takada, T; Takami, M; Tsukahara, Y; Watanabe, T | 1 |
| Barduagni, M; Bertuccelli, M; Calabresi, F; Carrai, M; Ceribelli, A; Cianci, C; De Marco, S; Falcone, A; Pfanner, E; Ricci, S | 1 |
| Aida, I; Kasuga, Y; Ohwada, M; Sato, I; Suzuki, M; Tamura, T | 1 |
| Adachi, E; Baba, H; Kounoe, S; Matsuoka, H; Miyazaki, N; Nagamine, S; Ohshiro, T; Saito, T; Seo, Y; Shiromizu, A | 1 |
| Eliason, JF; Givel, JC; Laurent, PL; Odartchenko, N; Tevaearai, HT | 1 |
| Hamano, K; Inada, N; Kawase, A; Kirita, T; Mabuchi, G; Miyashita, M; Seshimo, A | 1 |
| De Bruijn, EA; Eggermont, A; Gheuens, E; Van Bockstaele, D; van de Vrie, W; van der Heyden, S; Van Oosterom, A | 1 |
| Jin, H; Kano, M; Kinugasa, A; Nishigami, T; Sawada, K; Shimoyama, T; Shintani, S; Wada, M; Yamamura, M; Yamashita, M | 1 |
| Kikkawa, N; Kobayashi, K; Mishima, H; Shin, E; Takatsuka, Y; Tamaki, Y; Tono, T; Yagyu, T | 1 |
| Mori, T; Takahashi, K; Takahashi, T | 1 |
| Hiratsuka, M; Imaoka, S; Ishikawa, O; Kabuto, T; Kameyama, M; Nakamori, S; Nakano, H; Ohigashi, H; Sasaki, Y; Yasuda, T | 1 |
| Haruta, A; Ikeda, S; Jyozaki, H; Tanaka, S; Toriya, H; Umeno, T | 1 |
| Matoba, N; Nagata, T; Niiyama, H; Yoshida, J | 1 |
| Asaumi, S; Iino, Y; Ishikawa, H; Iwanami, K; Kawashima, K; Kobayashi, J; Kubota, K; Matsumoto, H; Morishita, Y; Yokoe, T | 1 |
| Hanaoka, T; Hikita, H; Horigome, N; Kouzu, S; Kuwae, K; Miyakawa, M; Senga, O; Yoshida, K | 1 |
| Horichi, H; Kumaki, T; Matsuki, N; Shima, K; Tajima, H; Takeda, T | 1 |
| Ito, T; Komatsu, Y; Moriya, N; Ogasawara, H; Saito, S; Sakata, Y; Sugimoto, N; Tamura, Y; Tsushima, K; Yamada, Y | 2 |
| Akashi, Y; Hachiya, Y; Miyoshi, A; Noshiro, H; Tohma, H | 1 |
| Eriguchi, M; Fujii, Y; Hasumi, K; Itoyanagi, H; Saegusa, Y | 1 |
| Ebihara, Y; Hirota, T; Koyanagi, Y; Kusama, M; Matsunaga, T; Nakamura, Y; Sekine, M; Serizawa, H | 1 |
| Antimi, M; Majoli, L; Minelli, M; Pandolfi, A; Papa, G; Stampino, CG | 1 |
| Akita, Y; Anzai, K; Arai, K; Ishii, M; Itoh, T; Kawada, T; Kawamura, M; Mitamura, K; Nishida, H; Onuki, M | 1 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Morinaga, A; Nakano, M; Saneyoshi, M | 1 |
| Hachisuka, K; Honda, H; Honda, K; Maeda, A; Nakazato, H; Tsuruga, N; Yamaguchi, A; Yoshizaki, S; Yura, J | 1 |
| Fukagawa, H; Hirohashi, Y; Iwanaga, A; Iyama, A; Kitahara, K; Miyazaki, K; Mori, M; Sasatomi, E; Tsutsumi, N; Yakushiji, H | 1 |
| Etoh, T; Maeda, Y; Matoba, N; Nagata, T; Niiyama, H; Yoshida, J | 1 |
| Funatsuka, M; Naitoh, A; Tamura, K; Yamamoto, T; Yano, S | 1 |
| Conte, PF; Ducci, F; Falcone, A; Laddaga, M; Pandolfi, A; Spagnesi, S; Stampino, CG | 1 |
| Eda, H; Fujimoto-Ouchi, K; Ishikawa, T; Ishitsuka, H; Mori, K; Ninomiya, Y; Tamura, S; Tanaka, Y | 1 |
| Kurihara, M | 1 |
| Kumagai, K; Masuo, K; Nishida, Y; Yasui, A; Yoshitoshi, A | 1 |
| Hanyu, F; Hayashi, T; Igarashi, T; Suzuki, M; Watanabe, K; Yoshida, K | 1 |
| Fukui, H; Imamura, I; Takechi, T; Takeda, S; Wada, H; Yabumoto, M; Yamada, Y | 1 |
| Aoyagi, K; Kakegawa, T; Kodama, I; Kofuji, K; Kumegawa, H; Maruiwa, M; Ohta, J; Takeda, J; Tanaka, T | 1 |
| Akazawa, S; Betsuyaku, T; Imamura, A; Koizumi, W; Kurihara, M; Morise, K; Ohkubo, S; Sasai, T; Takahashi, H; Yoshida, S | 1 |
| el Kouni, MH; el Kouni, MM; Naguib, FN | 1 |
| Eda, H; Fujimoto, K; Hino, A; Ishitsuka, H; Tanaka, Y; Ura, M; Wada, K; Watanabe, S | 1 |
| Alberto, P | 1 |
| Barbour, KW; Berger, FG; Berger, SH; Hughey, CT | 1 |
| Masuyama, H; Shimizu, S; Suzuki, H; Takeshita, T; Tanahasi, T; Toyama, T | 1 |
| Hirayama, R; Ichikawa, W; Mishima, Y; Miyanaga, T; Nihei, Z; Sawai, S; Shoji, Y; Yamashita, T; Yoshinaga, K | 1 |
| De Lena, M; Guerrieri, A; Lorusso, V; Palmisano, F; Zambonin, PG | 1 |
| Amadori, D; Bajetta, E; Calabresi, F; Colleoni, M; Comella, G; Lorusso, V; Marangolo, M; Rosso, R; Scanni, A; Sobrero, A | 1 |
| Fukuda, I; Irie, K; Iwanaga, T; Kikkawa, N; Okumura, S; Sakai, K; Shimoyama, T; Taguchi, T; Terasawa, T; Yasutake, K | 1 |
| Kikkawa, N; Tsumura, I | 1 |
| Dohi, K; Gotoh, T; Kataoka, T; Nishiki, M; Okamoto, T; Sadamoto, S | 1 |
| Eda, H; Fujimoto, K; Ishikawa, T; Ishitsuka, H; Ohiwa, T; Tanaka, Y; Tatsuno, K; Watanabe, S | 1 |
| Fujii, A; Hamano, K; Kamio, T; Katoh, T; Kimura, T; Muraki, H; Yamamoto, K | 1 |
| Higashi, Y; Inoue, K; Kanoh, T; Kurihara, T; Suemasu, K; Tabei, T | 1 |
| Hirano, M; Kato, A; Kikkawa, H; Kitagawa, K; Masuda, S; Mori, H; Murakami, N; Oosawa, T; Saito, H; Watanabe, S | 1 |
| Agata, N; Hirano, S; Iguchi, H; Izumi, H; Mase, T; Takeuchi, T; Tone, H | 1 |
| Ishikawa, S; Katsube, T; Konno, S; Miura, K; Naritaka, Y; Ogawa, K; Shimakawa, T; Wakasugi, S; Watanabe, T; Yagawa, H | 1 |
| Abe, H; Kurosu, Y; Niki, M; Tsuzuki, H; Ueda, H | 1 |
| Artale, S; Bajetta, E; Carnaghi, C; Colleoni, M; Di Bartolomeo, M; Di Leo, A; Pandolfi, A; Rimassa, L; Zilembo, N | 1 |
| Mizuno, M; Ogino, M; Tanaka, Y; Tokuda, H; Yamauchi, M | 1 |
| Abe, O; Abe, R; Enomoto, K; Iino, Y; Koyama, H; Nakazato, H; Nomura, Y; Tominaga, T | 1 |
| Hirayama, R; Kojima, K; Mishima, Y; Nakamura, T; Nihei, Z; Shirota, Y; Tohyama, Y; Yasuda, S | 1 |
| Andou, T; Hori, K; Kimura, S; Koumoto, T; Takagaki, M; Tsuji, K | 1 |
| Fukushima, S; Hamada, A; Kawaguchi, T; Nakano, M; Saneyoshi, M; Shimizu, S | 2 |
| Kimura, M; Koida, T; Sekihara, M | 1 |
| Anderson, TD; Hayes, TJ; Horii, I; Inoue, T | 1 |
| Furukawa, J; Kinuta, M; Maruhashi, S; Maruyama, H; Masuda, N; Matsui, S; Okamura, J; Ooi, H; Takiguchi, S; Tateishi, H; Tokunaga, M; Yano, H; Yayoi, E | 1 |
| Matsumine, T; Matsumoto, J; Minami, T; Takami, M; Takanishi, K | 1 |
| Palmisano, F; Zambonin, CG | 1 |
| Fujiwara, T; Hizuta, A; Iwagaki, H; Orita, K; Perdomo, JA; Tanaka, N | 1 |
| Bajetta, E; Bordogna, G; Comella, G; Di Bartolomeo, M; Gebbia, V; Moreschi, M; Scanni, A; Somma, L; Stampino, CG; Turci, D | 1 |
| Baldini, E; Ceribelli, A; Comella, G; Conte, PF; Falcone, A; Pfanner, E; Ricci, S; Sarcina, R; Stampino, CG; Tibaldi, C | 1 |
| Hoshino, K; Ikeda, H; Kamoshita, N; Kobayashi, J; Koyama, T; Morishita, Y; Nakamura, M; Tanaka, T | 1 |
| Hino, A; Ishitsuka, H; Matsumoto, T; Mori, K; Nishida, M; Yoshikubo, T | 1 |
| Arano, Y; Hirano, M; Ishikawa, N; Kikuchi, T; Kitsukawa, H; Kurokawa, M; Murakami, N; Nagao, S; Saito, H | 1 |
| Fukushima, M; Nakano, K; Saito, H; Satake, H; Takechi, T; Takeda, S; Uchida, J; Unemi, N | 1 |
| Gangi, J; Matsui, T; Miyoshi, K; Sezaki, N; Shinoura, S | 1 |
| Kato, Y; Matsukawa, S; Muraoka, R; Tanigawa, N | 1 |
| Doi, O; Furukawa, H; Hiratsuka, M; Imaoka, S; Ishikawa, O; Iwanaga, T; Kabuto, T; Kameyama, M; Nakamori, S; Ohigashi, H; Sasaki, Y; Yasuda, T; Yokouchi, H | 1 |
| Arase, Y; Chayama, K; Ikeda, K; Kobayashi, M; Koida, I; Kumada, H; Murashima, N; Saitoh, S; Suzuki, Y; Tsubota, A | 1 |
| Abe, S; Akao, S; Ishikawa, H; Kojima, M; Soma, R; Yoshida, M | 1 |
| Ariga, T; Kinoshita, H; Maeda, T; Maruyama, T; Ohshima, I; Ozaki, M; Shimada, H; Shoko, T; Takeda, A; Yoshimura, S | 1 |
| Fujiwara, K; Gotoh, K; Houkan, T; Midoro, K; Ootsu, K; Yukishige, K | 1 |
| Ando, S; Katanuma, A; Maekubo, H; Mori, M; Tsuji, K | 1 |
| Fujimaki, M; Katuyama, S; Kuroki, Y; Okamoto, M; Sakamoto, T; Tazawa, K; Yamashita, I | 1 |
| Baba, H; Kohnoe, S; Matsuoka, H; Morita, M; Saito, T; Seo, Y; Taketomi, A; Tomoda, H | 1 |
| Kuribayashi, H; Nishibe, M; Nishihara, H; Sato, T; Watanabe, I | 1 |
| Artale, S; Bajetta, E; Bignami, P; Buzzoni, R; Del Vecchio, M; Di Bartolomeo, M; Magnani, E; Somma, L; Zunino, F | 1 |
| Endo, M; Fujimoto-Ouchi, K; Ishitsuka, H; Matsumoto, T; Tanaka, Y | 1 |
| Enomoto, M; Fukunari, H; Ichikawa, W; Iwasaki, A; Kitago, K; Nihei, Z; Sanada, K; Shibata, M; Tomita, H | 1 |
| Asanuma, F; Miyagawa, T; Toyoda, H; Uesato, K; Yamada, Y | 1 |
| Hamada, A; Hasegawa, T; Kawaguchi, T; Nakano, M; Shimidzu, S | 1 |
| Asano, K; Fujita, H; Izumi, R; Kanno, M; Kojima, Y; Konishi, K; Matsuki, N; Miyata, R; Miyazaki, I; Mura, T; Nishimura, G; Ooto, T; Sasaki, T; Sawa, T; Syouji, M; Takada, M; Takeyama, S; Takigawa, Y; Takita, Y; Ueda, H; Ueno, K; Yamazaki, H | 1 |
| Paillard, F | 1 |
| Denning, C; Pitts, JD | 1 |
| Katsumata, K; Kawasaki, M; Koyanagi, Y; Kusama, M; Moriwaki, R; Murano, A; Nagakawa, Y; Ogata, T; Shibata, K; Yamamoto, K | 1 |
| Aiba, S; Endo, K; Fujii, T; Horiguchi, J; Iino, Y; Ishida, T; Kishi, S; Kusaba, T; Maemura, M; Morishita, Y; Ohwada, S; Shiozaki, H; Sugamata, N; Takano, A; Takei, H; Takeyoshi, I; Yokoe, T; Yokomori, T | 1 |
| Fujita, I; Hiramoto, Y; Ikeda, K; Kiyama, T; Matsukura, N; Mizutani, T; Oguri, T; Okuda, T; Onda, M; Shirakawa, T; Takita, M; Teramoto, T; Tokunaga, A; Yoshiyuki, T | 1 |
| Fukase, Y; Ishikawa, T; Ishitsuka, H; Sawada, N; Sekiguchi, F | 1 |
| Shin, E; Takatsuka, Y | 1 |
| Hen-mi, K; Ishida, Y; Iwai, N; Kaneko, I; Matsumoto, S; Nakamura, T; Ohtoshi, M; Satoh, B; Shibagaki, F; Soda, M; Sugihara, J; Yamasaki, T | 1 |
| Amaike, H; Kan, K; Kawachi, H; Mizuta, N; Naitoh, K; Ohmori, K; Ohmori, Y; Tsuruta, A; Yanada, M | 1 |
| Hatae, M; Onishi, Y | 1 |
| Hasegawa, K; Hasuo, Y; Hatae, M; Honjo, H; Kobashi, Y; Kudo, T; Mizutani, K; Nishimura, R; Noda, K; Ochiai, K; Onishi, Y; Ozaki, M; Sasaki, H; Sato, S; Sugiyama, T; Terashima, Y; Yajima, A; Yakushiji, M; Yamamoto, K; Yamamoto, T | 1 |
| Adachi, A; Nishida, T; Ohta, Y; Sasaki, N; Shima, Y; Yamayoshi, T | 1 |
| Mastrolitti, S; Palmisano, F; Zambonin, CG | 1 |
| Nakagawa, T; Sawai, Y; Yamaoka, K | 1 |
| Fukase, Y; Ishikawa, T; Ishitsuka, H; Sekiguchi, F; Yamamoto, T | 1 |
| Ichikawa, W; Iida, S; Miyanaga, T; Nihei, Z; Nishi, N; Osanai, T; Shimizu, C; Sugihara, K; Togo, S; Uetake, H; Yamashita, T | 1 |
| Furukawa, H; Hiratsuka, M; Imaoka, S; Ishikawa, O; Kabuto, T; Kameyama, M; Murata, K; Nakano, H; Ohigashi, H; Sasaki, Y; Tsugawa, T; Yasuda, T | 1 |
| Furukawa, H; Gotoh, T; Hioki, K; Hirakawa, K; Isozaki, H; Iwanaga, T; Kikkawa, N; Kuwata, H; Kuwata, K; Matsunaga, S; Miyazaki, H; Nakajima, T; Nakano, H; Nakazato, H; Okajima, K; Sowa, M; Takahashi, S; Takami, M; Takebayashi, J; Tokuda, H; Toyohara, M; Tsukahara, Y; Watanabe, A; Yagi, M; Yamasaki, Y | 1 |
| Bajetta, E; Biganzoli, L; Buzzoni, R; Carnaghi, C; Cassata, A; Di Bartolomeo, M; Galante, E; Mariani, L; Spagnoli, I; Stampino, CG | 1 |
| Amano, M; Haba, A; Ikeda, K; Izawa, H; Kanoh, T; Monden, M; Monden, T; Ohnishi, T; Okamura, J; Sekimoro, M; Tomita, N; Tsujie, M | 1 |
| Horie, H; Hosoya, Y; Ishizuka, T; Kanazawa, K; Kashiwagi, H; Kojima, M; Konishi, H; Shitou, K | 1 |
| Fujita, K; Hirano, Y; Suzuki, K; Takayama, T; Ushiyama, T | 1 |
| Chimori, Y; Fujita, Y; Ikoma, H; Nanri, M; Oguro, A; Yamane, E | 1 |
| Henmi, K; Ishida, Y; Iwai, N; Kaneko, I; Matsumoto, S; Nabeyama, A; Nakamoto, M; Ohtoshi, M; Ono, S; Shibagaki, F; Soda, M; Takao, K; Yamasaki, T; Yamasaki, Y | 1 |
| Agostino, I; Andreoli, F; Bartolini, P; Gemelli, MT; Neri, B; Pantalone, D; Pernice, ML; Scatizzi, M; Siliani, GM | 1 |
| Akatsuka, H; Igari, H; Ishihata, R; Ito, K; Kojima, Y; Sato, Y; Sekikawa, K; Takano, M | 1 |
| Collins, WP; Farzaneh, F; Hata, K; Miyazaki, K; Stevenson, DP | 1 |
| Kihara, M; Maeda, M; Matsusaka, K; Miyauchi, A | 1 |
| Ishikawa, T; Ishitsuka, H; Miwa, M; Mori, K; Nishida, M; Sawada, N; Shimma, N; Umeda, I; Ura, M | 1 |
| Fujitake, S; Kataoka, S; Maeda, Y; Nozaki, H; Shimizu, M; Tohyama, M | 2 |
| Fukumura, K; Higashimori, M; Nakagawa, T; Yamaoka, K | 1 |
| Hasegawa, M; Kitagawa, S; Sato, S | 1 |
| Ahn, MJ; Baik, HK; Choi, IY; Choi, NW; Han, DS; Jeon, YC; Jun, DW; Lee, HG; Nam, YS; Park, HK; Sohn, JH | 1 |
| Cano, JP; Cuq, P; Evrard, A; Pèlegrin, A; Robert, B; Vian, L | 1 |
| Tominaga, T | 1 |
| Fujii, H; Kumagai, K; Terai, Y; Ueda, M; Ueki, K; Ueki, M; Yanagihara, T; Yoshizawa, K | 1 |
| Fujita, K; Hirano, Y; Suzuki, K; Ushiyama, T | 1 |
| Ishikawa, S; Miyazaki, M; Morimoto, Y; Nagai, I; Sumimura, J | 1 |
| Koizumi, W; Kurihara, M; Nakamaru, N; Okayasu, I; Saigenji, K | 1 |
| González Barón, M | 1 |
| De Bruijn, EA; Highley, MS; Maes, RA; Reeuwijk, HJ; Tjaden, UR; Van Der Heyden, SA; Van Oosterom, AT; Van Slooten, H | 1 |
| Higashi, Y; Inoue, K; Kurosumi, M; Suemasu, K; Tabei, T | 1 |
| Fujiwara, Y; Kanyama, H; Miyoshi, Y; Monden, M; Ohue, M; Sakita, I; Sekimoto, M; Tamaki, Y; Tomita, N; Yamano, T | 1 |
| Fushimi, H; Hazama, K; Honda, M; Inoue, Y; Matsuo, Y; Takao, T; Tanaka, Y; Yamamoto, S | 1 |
| Morimoto, T; Nishiki, M; Senoo, T; Sonoo, H; Takashima, S | 1 |
| Aihara, S; Hiki, Y; Ishikawa, H; Kakita, A; Kanazawa, H; Ohtani, Y | 1 |
| Hoshino, K; Ikeda, H; Koyama, T; Morishita, Y; Nakamura, M | 1 |
| Kuroda, T; Mizutani, H; Nakamura, Y; Tadaoka, N; Takahashi, N | 1 |
| Egashira, Y; Gotoh, M; Hirata, I; Inoue, R; Inoue, T; Itabashi, T; Iyama, M; Katsu, K; Kurisu, Y; Shimamoto, C; Takiuchi, H; Tanaka, M | 1 |
| Endo, M; Fukase, Y; Ishikawa, T; Ishitsuka, H; Sawada, N; Shinbori, N; Tanaka, Y | 1 |
| Cano, JP; Ciccolini, J; Cuq, P; Evrard, A; Vian, L | 1 |
| Kazui, T; Kimura, T; Kobayashi, T; Sugimura, H; Suzuki, K; Uno, T; Yoshida, M; Yoshida, T | 1 |
| Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
| Ekimoto, H; Mashiba, H; Matsumoto, S; Okamoto, K | 1 |
| Fukuda, K; Kim, YH; Kitano, H; Kokufu, I; Taniguchi, H; Yamada, K; Yamamoto, M; Yano, T | 2 |
| Aoki, T; Kaise, H; Koyanagi, Y; Kusama, M; Matsunaga, T; Nakamura, Y; Nakayama, S; Yoneda, K | 1 |
| Artale, S; Bajetta, E; Bozzetti, F; Buzzoni, R; Di Bartolomeo, M; Mazzaferro, V; Ricci, SB; Stani, SC; Toffolatti, L | 1 |
| Koizumi, W; Kokutou, M; Koshida, Y; Kurihara, M; Saigenji, K; Soh, I; Tanabe, S; Tanigawa, H; Watanabe, M | 1 |
| Arime, I; Kunisue, H; Kurebayashi, J; Shimozuma, K; Sonoo, H; Tanaka, K; Udagawa, K; Yamamoto, S; Yamamoto, Y | 1 |
| Ikemoto, S; Kishimoto, T; Sugimura, K; Wada, S; Yamamoto, K; Yasumoto, R | 1 |
| Fukushima, H; Goya, T; Hanaoka, T; Matsuda, M; Sato, K; Tanaka, R | 1 |
| Kawasaki, K; Kishibuchi, M; Nishi, T; Yagyu, T; Yamasaki, M; Yasui, M; Yayoi, E | 1 |
| Kido, T; Nakahara, M; Nakao, K; Nishi, H; Tsujimoto, M; Yamanishi, H | 1 |
| Goto, T; Ishimaru, K; Kano, Y; Kiyono, T; Koga, T; Nishiwaki, M; Okuda, K; Sumiyama, M; Tsujitsuka, K | 1 |
| Adenis, A; Conroy, T; Paillot, B | 1 |
| Musha, N; Oka, K; Saito, H; Sando, N; Sasaki, M; Setu, M; Setu, Y; Sunami, E | 1 |
| Hohya, I; Idezuki, Y; Ishida, H; Nakada, H; Suzuki, T; Takeuchi, I; Yamada, H | 1 |
| Hayashida, H; Higuchi, K; Okada, Y; Soga, H; Yoshiki, T | 1 |
| Amano, M; Haba, A; Monden, M; Monden, T; Ohue, M; Sakita, I; Sekimoto, M; Tamaki, Y; Tomita, N | 1 |
| Fujimoto, S; Nakajima, N; Nakazato, H; Saitoh, N; Takiguchi, N | 1 |
| Amano, G; Furuta, A; Harada, Y; Ikegaki, H; Kijima, G; Ohnuki, K; Ohuchi, N; Satomi, S; Yoshida, R | 1 |
| Gen, T; Hara, Y; Igarashi, K; Jibiki, M; Kawasaki, T; Kikuchi, M; Kudoh, A; Noguchi, N; Yabata, E | 1 |
| Kokawa, Y; Naito, Y; Oura, S; Sakurai, T; Tamaki, T; Umemura, T; Yoshimura, G | 1 |
| Britten, C; Hammond, L; Hidalgo, M; Rothenberg, ML; Sharma, A; Sharma, S; Siu, L; Villalona-Calero, M; Weiss, GR | 1 |
| Fujii, T; Hanaoka, T; Ishida, K; Kawashima, K; Mihara, Y; Takahashi, T | 1 |
| Field, WN; Hussey, HJ; Inagaki, N; Ishitsuka, H; Tanaka, Y; Tisdale, MJ; Todorov, PT | 1 |
| Mai, M; Nishioka, K; Taguchi, T; Takahashi, Y; Urushizaki, I | 1 |
| Hirakawa, Y; Kawaguchi, Y; Kuwata, K; Matsushima, E; Nagayama, S | 1 |
| Ashino, Y; Kanno, A; Kanzaki, N; Kashimura, S; Kawahara, Y; Miyazawa, M; Muto, A; Sato, M | 1 |
| Katagata, N; Matsuoka, T; Nomizu, T; Takenoshita, S; Tsuchiya, A; Watanabe, F; Yabuta, T; Yamaki, Y | 1 |
| Au, JL | 1 |
| Kimura, T; Kobayashi, T | 1 |
| Chiba, K; Ebato, T; Fukuda, M; Fukuoka, H; Fukushima, S; Hirokawa, M; Hosaka, M; Ikeda, I; Kanno, H; Kitami, K; Kondo, I; Kubota, Y; Masuda, M; Miura, T; Miyai, K; Moriyama, M; Noguchi, K; Noguchi, S; Sasaki, K; Sato, K; Senga, Y | 1 |
| Takahashi, H; Todo, S | 1 |
| Akasaka, Y; Hata, Y; Nakanishi, Y; Ogita, M; Sasaki, F; Sawada, Y; Takahashi, H; Uchino, J; Yoshimoto, M | 1 |
| Iwase, T; Iwata, H; Miura, S; Mizutani, M; Murai, H | 1 |
| Kim, NK; Min, JS; Noh, JK; Park, JK; Yun, SH | 1 |
| Fan, J; Ma, ZC; Qin, LX; Tang, ZY; Wang, BL; Wang, JH; Wu, ZQ; Zeng, ZC; Zhong, CS; Zhou, J | 1 |
| Allegrini, G; Bartolozzi, C; Brunetti, I; Conte, PF; Di Marsico, R; Falcone, A; Fontana, E; Lencioni, M; Masi, G; Orlandini, C; Pfanner, E; Stampino, CG | 1 |
| Aiba, K; Horikoshi, N; Saotome, T; Yoshida, N | 1 |
| Arai, K; Inoue, S; Iwasaki, Y; Kawahara, Y; Kitamura, M; Maeshiro, T; Miyamoto, Y; Ohashi, M; Saiura, A; Takahashi, T; Tanaka, S; Umekita, N | 1 |
| Maeda, Y; Sasaki, F; Taguchi, K; Takahashi, H; Todo, S; Watanabe, K | 1 |
| Furukawa, J; Hashimoto, T; Katsumoto, Y; Nakaguchi, K; Okajima, S; Shingai, T; Sue, F; Takekuni, K; Teshima, S; Yoshioka, S; Yukawa, M | 1 |
| Katayama, A; Mafune, K; Makuuchi, M | 1 |
| Fujii, M; Kaiga, T; Ueda, T; Watanabe, Y | 1 |
| Ino, H; Kanaya, Y; Kawasaki, K; Maruyama, S; Okumoto, T; Otani, J; Soda, M; Yokoyama, N | 1 |
| Akao, S; Hiraide, H; Ishikawa, H; Maruyama, M; Matsumoto, F; Mochizuki, H; Okamura, H; Sato , K; Tabei, T; Tamakuma, S; Touma, M; Yagi, Y | 1 |
| Emoto, K; Etoh, T; Ichiba, Y; Imaoka, Y; Ishizaki, Y; Sumimoto, R; Takahashi, M; Tokumoto, N | 1 |
| Matubara, Y; Oyamatu, M; Tamiya, Y | 1 |
| Aoki, S; Hamamatsu, C; Hirata, K; Hirayama, T; Kawasaki, H; Matsunaga, T; Nakagawa, N; Nakayama, I; Oono, K; Sasaki, K; Shibata, K; Takaoka, A; Takasaka, H; Yabana, T; Yamamoto, Y | 1 |
| Gu, J; Liu, H; Qiao, X; Tong, F; Wang, S; Yang, D; Zhang, J | 1 |
| Fukuda, Y; Hirao, S; Kinoshita, H; Koyama, I; Mayumi, K; Takatori, H; Terakura, M; Tsukazaki, Y | 1 |
| Jung, HC; Kim, NK; Min, JS; Park, JK; Roh, JK; Sung, JS; Yun, SH | 1 |
| Matsuzaki, A; Morita, T; Tokue, A | 1 |
| Fujimoto-Ouchi, K; Tanaka, Y; Tominaga, T | 1 |
| Baba, H; Ebuchi, M; Kure, N; Maruyama, M; Nagahama, T; Toukairin, Y; Yoshida, T | 1 |
| Casado, FJ; Fernández-Veledo, S; García-Manteiga, JM; Guillén-Gómez, E; Larrayoz, IM; Lloberas, J; Lostao, MP; Mata, JF; Pastor-Anglada, M | 1 |
| Cho, JH; Kim, NK; Min, JS; Seong, J; Suh, CO | 1 |
| Aoyama, H; Asaga, T; Iwase, H; Kimura, M; Mitsuyama, S; Nishimura, R; Tominaga, T | 1 |
| Aihara, N; Fukunaga, M; Iba, T; Kidokoro, A; Suda, M; Sugiyama, K | 2 |
| Chazal, M; Dubreuil, A; Etienne, MC; Fischel, JL; Marchetti, S; Milano, G | 1 |
| Arai, T; Esaki, Y; Fukazawa, T; Sawabe, M; Takubo, K; Tsuru, M | 1 |
| Kato, S; Onda, M; Tanaka, N; Tanaka-Nozaki, M | 1 |
| Ishii, R; Koda, K; Miyazaki, M; Oda, K; Takiguchi, N | 1 |
| Fujita, H; Hiki, Y; Ike, H; Mitomi, T; Otani, Y; Oya, K; Sadahiro, S; Shimada, H; Yamaguchi, S | 1 |
| Eriguchi, M; Matsuzawa, A; Nonaka, Y; Takeda, Y; Yanagie, H; Yoshizaki, I | 1 |
| Akaike, H; Ashizawa, I; Chiba, S; Imamura, K; Mitui, T; Miyauchi, Y; Muto, S; Nakagomi, H; Nakazawa, M; Okuda, J; Takahashi, M | 1 |
| Fujioka, M; Hashimoto, D; Hoshino, T; Inokuma, S; Ishida, H; Ishizuka, N; Matsumoto, Y; Miura, T; Murata, N; Nakada, H; Odaka, A; Ohsawa, T; Takeuchi, I; Yamada, H; Yokoyama, M | 1 |
| Kunisue, H; Kurebayashi, J; Kurosumi, M; Otsuki, T; Sonoo, H; Tanaka, K; Yamamoto, S | 1 |
| Higashigawa, M; Kagawa, Y; Kakito, H; Kawasaki, H; Kojima, M; Ohkubo, T; Ooi, A; Sakurai, M | 1 |
| Chino, Y; Ogata, M; Suzuki, Y; Tani, T; Ubukata, N; Yoshihara, K | 1 |
| Araki, Y; Hayashi, A; Ishibashi, N; Kishimoto, Y; Konishi, J; Matono, K; Mituoka, M; Miyagi, Y; Nakagawa, M; Nozoe, Y; Ogata, Y; Sasatomi, T; Shirouzu, K | 1 |
| Egawa, N; Kamisawa, T; Karasawa, K; Okamoto, A; Takahashi, T; Tsuruta, K | 1 |
| Baldwin, SA; Cass, CE; Clarke, ML; Coupland, RW; Dabbagh, L; Jennings, LL; Koski, SL; Mackey, JR; Santos, CL; Vsianska, M; Young, JD | 1 |
| Katagiri, T; Kitahara, S; Nonaka, K; Ogata, H; Shiba, T | 1 |
| Fujitani, K; Hirao, M; Kobayashi, K; Tamaki, Y; Tsujinaka, T | 1 |
| Fujioka, A; Fukushima, M; Nakagawa, F; Nukatsuka, M; Ohshimo, H | 1 |
| Abe, O; Abe, R; Asaishi, K; Enomoto, K; Hattori, T; Hayasaka, H; Hirata, K; Izuo, M; Kimijima, I; Koyama, H; Miura, S; Monden, Y; Morimoto, T; Nakazato, H; Nomura, Y; Ohashi, Y; Ota, J; Senoo, T; Sonoo, H; Sugimachi, K; Taguchi, T; Toge, T; Toi, M; Tominaga, T; Uchino, J; Watanabe, H; Yamaguchi, S; Yoshida, M | 1 |
| Otsuka, T; Tashiro, S; Terashima, Y | 1 |
| Aoyagi, K; Basaki, Y; Chikahisa, L; Hashimoto, A; Miyadera, K; Okabe, S; Wierzba, K; Yamada, Y; Yonekura, K | 1 |
| Imatomi, M; Miyamoto, H; Nakata, A; Saitoh, T; Yoshida, S | 1 |
| Iwahashi, M; Nagata, T; Nakamori, M; Yamaue, H | 1 |
| Boku, N; Fukuda, H; Ikeda, N; Iwase, H; Koizumi, W; Ohtsu, A; Saito, H; Shimada, Y; Tsuji, Y; Yoshida, S | 1 |
| Anazawa, S; Aoki, T; Mukai, H; Ogawa, M; Satou, K; Takao, Y; Yamazaki, Y | 1 |
| Konishi, H; Matsuda, M; Minouchi, T; Morita, K; Nakajima, M; Yamaji, A | 1 |
| Abe, O; Ohashi, Y; Toi, M; Tominaga, T | 1 |
| Aoki, T; Kaise, H; Koyanagi, Y; Kusama, M; Matunaga, T; Misaka, T; Nakayama, S; Ota, D | 1 |
| Fujioka, A; Fukushima, M; Kitazato, K; Nakagawa, F; Nukatsuka, M; Ohshimo, H | 1 |
| Andreola, S; Baratti, D; Bozzetti, F; Mariani, L; Spinelli, P; Stani, SC; Valvo, F | 1 |
| Hirata, H; Matsuyama, H; Yamakawa, G | 1 |
| Fujita, K; Hirano, Y; Kageyama, S; Suzuki, K; Takayama, T; Ushiyama, T | 1 |
| Hotokezaka, M; Ishimitsu, T; Matsumoto, S; Nakamura, K; Takeda, S | 1 |
| Hiraoka, M; Inaji, H; Inoue, T; Kodama, H; Kono, M; Kono, N; Koyama, H; Sako, M; Suzuki, R | 1 |
| Hara, A; Harada, T; Iwamoto, S; Izumi, N; Matsubara, C; Satake, K; Tsunematsu, I | 1 |
| Ideguchi, K; Ikeda, Y; Mori, T; Nakagawa, K; Okamoto, K; Sakata, K; Yasumitsu, T | 1 |
| Ito, T; Nakamura, A; Sato, A; Taguchi, S; Tomita, T | 1 |
| Asaumi, Y; Hara, T; Hirano, M; Kikkawa, H; Kikuchi, T; Murakami, N; Nozawa, H; Takizawa, M; Uno, Y | 1 |
| Azuma, T; Hatada, T; Inoue, Y; Kusunoki, M; Miki, C; Mohri, T; Ojima, E | 1 |
| Qiao, X; Wang, S; Wang, Z; Ye, Y; Yu, Y; Zhu, F | 1 |
| Fukuoka, M; Hamada, M; Kaniwa, N; Matsumoto, Y; Murayama, N; Nakajima, Y; Ohno, Y; Ozawa, S; Sawada, J | 1 |
| Abe, K; Araya, M; Fujiwara, H; Irinoda, T; Nakaya, T; Oyama, K; Saito, K; Takagane, A; Takahashi, M; Terashima, M; Yonezawa, H | 1 |
| Kurihara, M; Matsukawa, M; Nakamachi, M; Sato, A; Shimada, K; Ushio, J; Yamamoto, W | 1 |
| Brunner, M; Eichler, HG; Locker, G; Mader, RM; Mueller, M; Rizovski, B; Schrolnberger, C; Steger, GG; Wenzel, C | 1 |
| Homma, N; Inoue, Y; Muranaka, K; Obata, R; Tamaki, Y; Yanagi, Y | 1 |
| Ahn, JH; Kang, YK; Kim, JC; Kim, JG; Kim, TW; Kim, WK; Lee, JH; Lee, JS; Min, YJ; Yu, CS | 1 |
| Ishikawa, T; Ouchi, KF; Tanaka, Y; Yanagisawa, M | 1 |
| Fukushima, M; Ono, Y; Sawada, M | 1 |
| Konishi, H; Minouchi, T; Morita, K; Sato, T; Yamaji, A; Yoshimoto, T | 1 |
| Blesch, KS; Burger, HU; Gieschke, R; Reigner, B; Steimer, JL | 1 |
| Kim, R; Murakami, S; Toge, T | 1 |
| Abe, O; Asaishi, K; Hirata, K; Ikeda, T; Kimijima, I; Koyama, H; Miura, S; Monden, Y; Morimoto, T; Noguchi, S; Nomura, Y; Ohashi, Y; Ota, J; Sonoo, H; Sugimachi, K; Toge, T; Toi, M; Tominaga, T; Yamaguchi, S | 1 |
| Sakaguchi, K; Tsuchie, K; Yoneyama, F | 1 |
| Machida, Y; Nagai, T; Onishi, H; Yoshino, T | 1 |
| Koda, K; Kodaira, S; Miyazaki, M; Nakazato, H; Ogawa, K; Saito, N; Sarashina, H; Suwa, T; Suzuki, M; Watanabe, S | 1 |
| Kou, Y; Okamoto, Y; Okuyama, N; Sawada, T; Tominaga, T | 1 |
| Wu, Q; Wu, XT; Xu, BH; Zhang, YJ; Zheng, X | 1 |
| Kabashima, A; Kajiyama, K; Kuma, S; Sakaguchi, Y | 1 |
| Deneen, B; Denny, CT; Hamidi, H | 1 |
| Li, H; Wang, H; Xu, F; Zang, M | 1 |
| Fujiwara, S; Kikuchi, R; Noguchi, T; Suehiro, S; Uchida, Y | 1 |
| Shi, D; Wang, SM; Wang, WJ | 1 |
| Akao, S; Inoue, K | 1 |
| Miwa, K; Nishimura, G | 1 |
| Ciccolini, J; Dubreuil, A; Etienne, MC; Fischel, JL; Formento, JL; Formento, P; Magné, N; Marchetti, S; Milano, G; Renée, N; Tiffon, C | 1 |
| Goto, T; Kasumi, F; Kutomi, G; Makita, M; Nishimura, S; Tada, K; Tanabe, M; Tokudome, N; Yoshimoto, M | 1 |
| Kitami, C; Maruyama, S; Nihei, K; Tamiya, Y | 1 |
| Handa, R; Iijima, S; Kato, T; Kikkawa, N; Kurokawa, E; Naoi, Y; Oshima, S; Tsujie, M; Yamamoto, H | 1 |
| Heerschap, A; Kamm, YJ; Klomp, DW; Punt, CJ; van Laarhoven, HW | 1 |
| Hosogi, H; Nakagami, M; Ohsumi, K; Tokuka, A; Tokunaga, Y | 1 |
| Fujita, H; Itoh, Y; Iwase, M; Kitamura, H; Kuze, S; Nakazawa, H; Ohi, S; Oya, J; Tomono, H | 1 |
| Kato, H; Kondo, S; Sekishita, Y; Shiono, T; Suzuki, O | 1 |
| Ishii, K; Miwa, K; Nakamura, M; Ohnishi, I; Tsugawa, K | 1 |
| Higuchi, K; Ichikawa, J; Kitamura, T; Koizumi, W; Murakami, S; Nagaba, S; Nakai, H; Saigenji, K; Sasaki, T; Tahara, K; Takeuchi, H; Tanabe, S | 1 |
| Haraguchi, Y; Nakano, M; Okusawa, A; Shimizu, H; Suzuki, M; Takahashi, M | 1 |
| Li, HZ; Shi, BB; Song, ZL; Wang, H; Wang, HJ | 1 |
| Hata, T; Hikino, H; Kanazawa, A; Nagaoka, S; Nakamura, K; Ozaki, N; Sugimoto, S; Tokuka, A; Yamada, T | 1 |
| Guo, M; Jin, A; Mori, E; Mori, T; Qi, Y; Takasaki, S | 1 |
| Beryt, M; Konecny, GE; O'Callaghan, C; Pegram, MD; Pietras, R; Slamon, DJ | 1 |
| Kim, DE; Kim, DW; Kim, HJ; Roh, JK | 1 |
| Hyodo, I; Inaba, T; Miyaike, J; Nishina, T; Shiratori, Y; Suzuki, S | 1 |
| Liu, MJ; Matsuno, S; Mizoi, T; Sasak, I; Shiiba, K; Zhang, JM | 1 |
| Creer, S; Ishii, H; Kuroki, T; Mimori, K; Mori, M; Shiraishi, T; Taylor, S; Ueo, H | 1 |
| Chiba, K; Hosakawa, M; Katoh, M; Nakajima, M; Tabata, T; Tokudome, S; Yokoi, T | 1 |
| Ajani, JA; Itoh, N; Itoi, H; Shirasaka, T; Ueda, Y; Yamagishi, H; Yamashita, T | 1 |
| Ding, Q; Li, G; Wen, DG; Yan, CY; Zhang, YF | 1 |
| Cao, D; Pizzorno, G | 1 |
| Haseba, M; Nakao, S; Nakazaki, T; Shibata, K; Takahara, O; Taniguchi, H | 1 |
| Okazaki, Y; Yamada, T; Yuyama, Y | 1 |
| Fuchimoto, S; Inagaki, M; Miyoshi, K; Nakagawa, T; Ohsaki, T; Ohtsuka, S; Yumura, M | 1 |
| Ciccolini, J; Etienne-Grimaldi, MC; Fischel, JL; Formento, P; Milano, G | 1 |
| Hiro, J; Inoue, Y; Kobayashi, M; Kusunoki, M; Miki, C; Mori, K; Shirane, M; Tanaka, K; Yanagi, H | 1 |
| Hazama, S; Mori, N; Oka, M; Tamesa, T; Tangoku, A; Watanabe, Y; Yamamoto, S; Yoshimura, K | 1 |
| Harada, H; Imaizumi, H; Kosaka, T; Kuroda, M; Takashima, S; Tanaka, Y; Yokoi, M; Yoshitani, S | 1 |
| Fujitani, K; Hirao, M; Ikenaga, M; Kashiwazaki, M; Masuda, N; Mishima, H; Sawamura, T; Takeda, Y; Takeno, A; Tsujinaka, T | 1 |
| Baba, H; Emi, Y; Ishida, T; Kakeji, Y; Maehara, Y | 1 |
| Bang, SM; Chung, HW; Chung, JB; Kang, JK; Kim, JW; Lee, WJ; Park, SW; Seong, JS; Song, SY | 1 |
| Ikemoto, S; Kuratsukuri, K; Nakatani, T; Sugimura, K; Wada, S; Yoshida, N | 1 |
| Hashiguchi, H; Hirooka, Y; Kamasako, A; Nozaka, K; Ohgami, Y; Otani, S; Takebayashi, M; Tanida, O; Toyota, N; Wakatsuki, T | 1 |
| Hamada, K; Kakihara, Y; Kubota, K; Sawada, T; Tagaya, N | 1 |
| Akimoto, T; Hasegawa, K; Kishimoto, Y; Morimoto, Y; Sawai, T | 1 |
| Eliason, J; Hussain, M; Li, R; Li, Y; Sarkar, FH; Sarkar, SH | 1 |
| Ciccolini, J; Ferrero, JM; Fischel, JL; Formento, JL; Formento, P; Milano, G; Renée, N | 1 |
| Bacsó, Z; Eliason, JF; Megyeri, A; Shields, A | 1 |
| Carter, TB; Dansby, LM; Diskin, C; Radcliff, L; Stokes, TJ | 1 |
| Hasegawa, R; Hasegawa, S; Koda, K; Miyazaki, M; Oda, K; Seike, K; Takiguchi, N | 1 |
| Aoki, A; Baba, Y; Jojima, K; Matsuyama, H; Naito, K; Shimabukuro, T; Suga, A; Suyama, K; Uchiyama, K; Yamamoto, N | 1 |
| Fujimoto-Ouchi, K; Kato, T; Kikkawa, N; Mishima, H; Nishisho, I; Tanaka, Y; Tsujie, M; Tsujinaka, T; Yanagisawa, M | 1 |
| Deguchi, Y; Kamimura, K; Kaneko, I; Kii, E; Murata, T; Nonogaki, H; Tanaka, T; Tsubono, M; Yasumizu, R | 1 |
| Suda, T | 1 |
| Endo, S; Hidaka, S; Hirao, K; Hirasaki, S; Hyodo, I; Kajiwara, T; Kurita, A; Masumoto, T; Moriwaki, T; Nasu, J; Nishina, T; Tsuzuki, T | 1 |
| Ebi, H; Igarashi, T; Kawada, K; Minami, H; Saeki, T; Sasaki, Y; Sigeoka, Y; Ueda, R; Usubuchi, N | 1 |
| Fukami, Y; Hasegawa, H; Hiromatsu, T; Itazu, K; Kawai, K; Komatsu, S; Sakamoto, E; Tabata, T | 1 |
| Fan, J; Liu, YK; Shen, ZZ; Tang, ZY; Wu, ZQ; Xiao, YS; Xue, Q; Ye, SL; Zhao, Y; Zhou, J | 1 |
| Dantzig, AH; Johnston, PA; Kandasamy, RA; Perry, W; Pratt, S; Shepard, RL | 1 |
| Fujii, K; Fujino, S; Higashide, S; Hori, T; Inamoto, T; Kan, N; Lee, CJ; Maruhashi, K; Mise, K; Mitsumori, M; Nishimura, S; Okamoto, M; Okamura, T; Sawai, S; Takemoto, Y; Yamauchi, A | 1 |
| Kihara, M; Kontani, K; Yamauchi, A; Yokomise, H | 1 |
| Hayakawa, K; Miyake, K; Morimoto, T; Mukaihara, S; Nishino, M | 1 |
| Fujioka, A; Fukushima, M; Ikeda, K; Kitazato, K; Nakagawa, F; Ohshimo, H; Okabe, H; Takechi, T | 1 |
| Ishikawa, T; Nose, T; Sawada, N; Yutaka, T | 1 |
| Bollig, A; Du, QQ; Fan, ST; Liao, J; Sarkar, FH; Yu, B | 1 |
| Wang, HD; Zheng, JF | 1 |
| Hirose, K; Nishimura, M; Sawada, T | 1 |
| Fujimoto-Ouchi, K; Hata, K; Hiraga, T; Ikeda, F; Kitagaki, J; Tanaka, Y; Yoneda, T | 1 |
| Fukumitu, T; Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Ogo, S; Ohkita, A; Ozasa, H; Sasatomi, T; Shida, S; Shirouzu, K; Torigoe, S | 1 |
| Hamada, K; Kakihara, Y; Kubota, K; Mori, S; Nakagawa, A; Suzuki, N; Tachibana, M; Tagaya, N | 1 |
| Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Ogo, S; Ohkita, A; Ozasa, H; Sasatomi, T; Shirouzu, K | 1 |
| Deguchi, Y; Kamimura, K; Kaneko, I; Kii, E; Murata, T; Tsubono, M; Yasumizu, R | 1 |
| Guichard, SM; Jodrell, DI; Mayer, I | 1 |
| Aratake, K; Itabashi, M; Kameoka, S; Mitsuhashi, M; Ogawa, S; Seshimo, A; Shirotani, N | 1 |
| Hamada, T; Ichimura, W; Minagawa, N; Mino, K; Naito, H; Orimo, T; Shibazaki, W; Shinohara, T | 1 |
| Fujio, N; Fukuda, Y; Ihara, T; Koyama, I; Osugi, H; Takatori, H; Tsukazaki, T; Tsukazaki, Y | 1 |
| Lokiec, F; Rezaí, K; Urien, S | 1 |
| Ebisui, C; Fujimoto, T; Fujiwara, S; Fukuchi, S; Hasuike, Y; Hayashi, N; Kida, H; Sakita, I; Tsujie, M; Yoshida, T | 1 |
| Eguchi, H; Imaoka, S; Ishikawa, O; Kameyama, M; Kishi, K; Miyashiro, I; Murata, K; Noura, S; Ohigashi, H; Ohue, M; Sasaki, Y; Takachi, K; Tanaka, K; Yamada, T; Yano, M | 1 |
| Ebi, H; Minami, H | 1 |
| Fukumitsu, T; Ishibashi, N; Matono, K; Mizobe, T; Ogata, Y; Sasatomi, T; Shirouzu, K; Torigoe, S; Yamashita, N; Yanagawa, T | 1 |
| Cao, D; Pizzorno, G; Wan, L; Yan, R; Zeng, J | 1 |
| Akiyama, S; Baba, M; Furukawa, T; Gotanda, T; Haraguchi, M; Hongye, Z; Nakagawa, M; Sumizawa, T; Tachiwada, T; Tsuneyoshi, K | 1 |
| Fukasawa, T; Gotoh, H; Shoji, T; Taniwaka, K | 1 |
| Hatanaka, N; Hiraoka, K; Mizutani, S; Nakahara, M; Nakao, K; Okuma, K; Oyama, T; Sueyoshi, K; Taira, M; Takahashi, H; Tori, M; Uchikoshi, F; Ueshima, S; Yamagami, Y; Yoshidome, K | 1 |
| Abe, N; Fujita, S; Gonda, K; Ishigame, T; Ohki, S; Okada, R; Onogi, H; Saito, M; Sekikawa, K; Suzuki, S; Takenoshita, S | 1 |
| Ding, W; Luo, B; Ma, ZM; Sheng, JM; Teng, LS; Wang, M; Wang, SF; Wu, FS; Zhao, WH | 1 |
| Akagi, Y; Ikeda, S; Ishibashi, N; Matono, K; Mizobe, T; Mori, S; Murakami, H; Ogata, Y; Ozasa, H; Shirouzu, K | 1 |
| Goto, M; Katsu, K; Kawabe, S; Kii, T; Kuwakado, S; Nishitani, H; Ohta, S; Takiuchi, H; Tanaka, T | 1 |
| Cao, D; Pizzorno, G; Wan, L; Yan, R | 1 |
| Chung, JB; Kim, KS; Lee, WJ; Park, JY; Park, SW; Seong, J; Song, SY | 1 |
| Ikeda, M; Ishiguro, K; Kataoka, T; Komaki, K; Kurebayashi, J; Morimoto, T; Sonoo, H; Tanaka, K; Tangoku, A; Yoshizawa, K | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Masterson, AJ; Noordhuis, P; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Horii, I; Kawashima, A; Kobayashi, K; Nakano, K; Shindoh, H; Shishido, N | 1 |
| Le, HP; Müller, CE | 1 |
| Cano-Soldado, P; Casado, FJ; Hernández-Vargas, H; Molina-Arcas, M; Moreno-Bueno, G; Palacios, J; Pastor-Anglada, M | 1 |
| Akabane, H; Fujiyoshi, M; Gotoh, J; Hirokata, G; Imai, K; Kawai, T; Kita, K; Nakano, S; Takahashi, M; Yanagida, N | 1 |
| Hiro, J; Inoue, Y; Kusunoki, M; Miki, C; Nakatani, K; Nobori, T; Ojima, E; Toiyama, Y; Watanabe, H | 1 |
| Hosokawa, N; Kaji, M; Kubo, M; Miyatani, K; Mizuta, M; Shirakawa, K; Suwaki, K; Toyokawa, T; Udaka, T; Yamane, M | 1 |
| Enomoto, T; Katagiri, M; Kusachi, S; Nagao, J; Nagao, S; Nakamura, Y; Saida, Y; Sumiyama, Y; Watanabe, M | 1 |
| Kondo, T; Matsuo, R; Moon, Y; Ohkohchi, N; Ohshiro, Y; Takeshima, T; Todoroki, T; Yamamoto, Y | 1 |
| Ando, H; Bykowski, C; Dhananjeyan, MR; Erhardt, PW; Liu, J; Sarver, JG; Trendel, JA | 1 |
| Cricca, S; de Bruin, M; Laan, AC; Peters, GJ; Temmink, OH; Turksma, AW | 1 |
| Ando, Y; Hara, Y; Itoh, K; Itoh, Y; Iwase, H; Iwata, H; Karamatsu, S; Kobayashi, S; Kuzushima, T; Sugiura, H; Toyama, T; Yamashita, H; Yamashita, T | 1 |
| Peters, GJ; Prins, HJ; Temmink, OH; van Gelderop, E | 1 |
| Hatanaka, N; Mizutani, S; Nakahara, M; Nakao, K; Oyama, T; Tori, M; Uchikoshi, F; Ueshima, S; Yoshidome, K | 1 |
| Aoyagi, Y; Haku, K; Hayama, T; Matsuda, K; Mimura, T; Nakamura, K; Nozawa, K; Oomi, T; Watanabe, T; Yamada, H | 1 |
| Ebisui, C; Fujimoto, T; Fujiwara, S; Fukuchi, N; Hasuike, Y; Hayashi, N; Sakita, I; Tsujie, M; Yoshida, T | 1 |
| Ichikawa, K; Okuda, N; Takahashi, K; Yagi, Y | 1 |
| Doki, Y; Fujiwara, Y; Miyata, H; Monden, M; Takiguchi, S; Yasuda, T | 1 |
| Honda, J; Kai, N; Kikuchi, K; Kikukawa, H; Kuwahara, T; Matsumoto, K; Nakanishi, J; Takahashi, W; Ueda, S; Wada, Y | 1 |
| Amano, M; Fukunaga, M; Ikeda, K; Ikeda, M; Ikenaga, M; Ishida, H; Kato, T; Mishima, H; Monden, M; Murata, K; Ohnishi, T; Ota, H; Sakamoto, J; Sekimoto, M; Tominaga, S | 1 |
| Sasaki, T | 1 |
| Arai, W; Haruta, H; Hirashima, Y; Hosoya, Y; Hyodo, M; Kurashina, K; Nagai, H; Saito, S; Sakuma, K; Yasuda, Y; Yokoyama, T; Zuiki, T | 1 |
| Higashijima, J; Kurita, N; Miyamoto, H; Miyatani, T; Nishioka, M; Shimada, M; Yoshikawa, K | 1 |
| Murakami, S; Yamamoto, Y | 1 |
| Fujimori, Y; Hiraguri, M; Ishizone, S; Kumeda, S; Maruta, F; Miyagawa, S; Shimizu, F | 1 |
| Ishizu, K; Makuuchi, H; Sadahiro, S; Sunose, N; Tsuruo, T; Yamazaki, K; Yamori, T | 1 |
| Baldwin, J; Basche, M; Britten, CD; Camidge, DR; Darstein, C; Finn, RS; Gail Eckhardt, S; Gore, L; Holden, SN; Leong, S; Musib, L; O'Bryant, CL; Thornton, D | 1 |
| Bang, SJ; Joo, KR; Kim, H; Kim, MJ; Min, YJ; Nah, YW; Nam, CW; Park, JH; Park, NH; Shin, SJ | 1 |
| Fujitani, K; Furukawa, H; Goto, M; Imamoto, H; Imamura, H; Imano, M; Ishida, H; Kimura, Y; Narahara, H; Shimokawa, T; Takiuchi, H | 1 |
| Chang, KP; Chang, YS; Chen, LC; Hao, SP; Hsueh, C; Liang, Y; Tsang, NM; Yu, JS | 1 |
| Asaishi, K; Doi, T; Inaba, M; Kimura, M; Nishimura, R; Okamoto, Y; Okuyama, N; Takeuchi, H; Tamaki, N; Tominaga, T; Yanagita, Y | 1 |
| Hoshino, S; Maekawa, T; Mikami, K; Sakai, T; Shirakusa, T; Yamashita, Y | 1 |
| Emi, N; Ezaki, K; Handa, K; Hasegawa, A; Maruyama, F; Mizuta, S; Okamoto, M; Tsuzuki, M; Watanabe, M; Yamamoto, K; Yamamoto, Y | 1 |
| Jeong, EJ; Kim, CY; Kim, GH; Woo, YA | 1 |
| Li, RP; Liang, P; Tang, H | 1 |
| Domarkas, J; O'Hagan, D; Schweiger, LF; Winkler, M | 1 |
| Jinta, E; Sakurai, T; Shimizu, S; Suzuma, T; Umemura, T; Yoshimura, G | 1 |
| Chang, KY; Lee, YD | 1 |
| Abe, R; Fujiwara, H; Fukuyama, N; Hirano, T; Hirata, K; Hotokezaka, M; Imamura, T; Ito, H; Iwashita, A; Kato, H; Konomi, K; Kuroki, N; Miyazaki, R; Miyazaki, Y; Nakahara, S; Nakano, S; Sakamoto, Y; Shimokobe, T; Shiraishi, M; Terasaka, R | 1 |
| Higuchi, T; Iesato, H; Kawate, S; Matsumoto, H; Numaga, Y; Ohya, T; Okabe, T; Tago, K; Takeyoshi, I; Totsuka, O; Yokomori, T | 1 |
| Kitajima, Y; Miyazaki, K; Nakafusa, Y; Ohtsuka, T; Sato, S; Tanaka, M; Yakabe, T | 1 |
| Huh, JW; Kim, HR | 1 |
| Chang, Y; Chen, Y; Fan, H; Fang, F; Gupta, N; Kong, X; Liang, J; Liu, X; Wang, R | 1 |
| Beijnen, JH; Rosing, H; Schellens, JH; Vainchtein, LD | 1 |
| Baek, IH; Kang, W; Kwon, KI; Lee, BY | 1 |
| Araki, A; Hazama, S; Hinoda, Y; Kondo, H; Nagashima, A; Oka, M; Okayama, N; Shimizu, R; Yoshida, S; Yoshino, S | 1 |
| Hirakawa, M; Hirako, T; Koh, Y; Minami, S; Miyajima, N; Saitoh, T; Sasagawa, Y; Takanashi, K; Ueno, Y | 1 |
| Hataya, K; Kimura, M; Kobayashi, O; Koizumi, W; Nabeshima, K; Sato, A; Shimada, K; Takahashi, M; Tsuburaya, A; Yoshikawa, T; Yoshizawa, Y | 1 |
| Nakayama, T; Noguchi, S | 1 |
| Genda, T; Hori, S; Miki, A; Nakajima, M; Satoh, H; Sawada, Y; Suehira, M | 1 |
| Chang, YS; Chen, CC; Chen, LC; Liang, Y; Tsang, NM | 1 |
| Czejka, M; Farkouh, A; Gruenberger, B; Scheithauer, W; Schueller, J | 1 |
| Czejka, M; Farkouh, A; Scheithauer, W; Schueller, J | 1 |
| Hagedorn, C; Lipps, HJ; Magnusson, T; Ogris, M; Rupprecht, S; Seruggia, D; Wagner, E | 1 |
| Chen, Y; Liu, Q; Luo, J; Wang, J; Wang, X; Yan, Z | 1 |
| Hasegawa, I; Joh, T; Kajino, S; Kato, A; Nukaya, H; Tanaka, Y; Tokuda, H | 1 |
| Honda, T; Inagawa, H; Nishizawa, T; Soma, G; Yamamoto, I; Yoshimura, H | 1 |
| Chae, YS; Choi, GS; Jang, YS; Jeon, SW; Jun, SH; Jung, MK; Kang, BW; Kim, JG; Lee, SJ; Lim, KH; Moon, JH; Park, JS; Sohn, SK | 1 |
| Arra, C; Avallone, A; Bruzzese, F; Budillon, A; Chianese, MI; de Ruggiero, I; Di Cintio, A; Di Gennaro, E; Franco, R; Luciano, A; Moccia, T; Piro, G | 1 |
| Chen, J; Duan, X; Fan, T; Pan, D; Zhang, H | 1 |
| Ishikawa, H; Iwazaki, S; Izumi, M; Kakinuma, S; Kawate, S; Kobayashi, J; Kobayashi, M; Koyano, T; Makita, F; Nakagami, K; Nakamura, S; Ogawa, T; Ohya, T; Roppongi, T; Sakamoto, I; Sato, Y; Sunose, Y; Takeyoshi, I; Tanahashi, Y; Tomizawa, N; Yamada, T | 1 |
| Masuda, A; Nagata, Y | 1 |
| Saito, Y; Suzuki, Y; Tokuda, Y | 1 |
| Arakawa, K; Hirai, K; Ogawa, H; Sunose, Y; Takeyoshi, I; Totsuka, O; Toya, H; Yoshinari, D | 1 |
| Choijamts, B; Emoto, M; Kawarabayashi, T; Miyamoto, S; Naganuma, Y; Nakajima, K; Ogata, S; Shirota, K | 1 |
| Dolan, ME; Gorsic, LK; Huang, RS; Wen, Y; Wheeler, HE; Ziliak, DM | 1 |
| Gao, MQ; Huang, AM; Zhuo, LJ | 1 |
| Ikeda, O; Kitajima, Y; Miyoshi, A; Noshiro, H; Satoh, S; Yakabe, T | 1 |
| Jiang, J; Ju, J; Lu, B; Wu, C; Xu, X; Yan, H; Zhang, X; Zheng, X; Zhou, Q | 1 |
| Barham, W; Blackwell, TS; Chen, L; Connelly, L; Onishko, HM; Ostrowski, MC; Sherrill, TP; Yull, FE; Zabuawala, T | 1 |
| Ait-Tihyaty, M; Jean-Claude, BJ; Mihalcioiu, C; Rachid, Z | 1 |
| Kusuhara, T; Maeda, H; Nakayama, H; Tsuhako, M | 1 |
| Bellot, GL; Koh, D; Tan, WH; Tay, LL; Wang, X | 1 |
| Ishikawa, H; Iwazaki, S; Izumi, M; Kakinuma, S; Kamoshita, N; Kawate, S; Kobayashi, I; Kobayashi, J; Makita, F; Nakagami, K; Ohya, T; Okabe, T; Sakamoto, I; Sato, Y; Sunose, Y; Takeyoshi, I; Tanahashi, Y; Tomizawa, N; Yamada, T; Yoshinari, D | 1 |
| Chang, KP; Chang, YS; Chen, CC; Chen, LC; Hseuh, C; Liang, Y; Wu, CS | 1 |
| Chong, KT; Endoh, K; Fukuoka, M; Miyahara, S; Miyakoshi, H; Nagasawa, H; Nomura, M; Shuto, S; Taguchi, J; Takao, Y; Ueno, H; Wakasa, T; Yano, W; Yokogawa, T | 1 |
| Hasegawa, K; Kato, R; Kawamura, K; Kobayashi, Y; Okamoto, H; Sekiya, T; Udagawa, Y | 1 |
| Wang, QW; Xia, Q; Zhang, JM | 1 |
| Kusama, M | 1 |
| Casado, FJ; Molina-Arcas, M; Pastor-Anglada, M; Pérez-Torras, S; Trigueros-Motos, L | 1 |
| Harada, N; Kurasawa, M; Mori, K; Sato, Y; Yanagisawa, M; Yasuno, H | 1 |
| Hashizume, T; Kato, T; Kotake, K; Mori, T; Ohue, M; Sato, T; Takii, Y; Tango, T | 1 |
| Kondo, J; Nagashima, Y; Nakamura, M; Nishimura, T; Okada, T; Sakata, K | 1 |
| Chang, HM; Jang, SJ; Jung, HY; Kang, YK; Kim, BS; Kim, GY; Kim, TW; Lee, JL; Min, YJ; Oh, ST; Park, BK; Park, I; Park, YS; Ryu, MH; Yang, DH; Yook, JH; Zang, DY | 1 |
| Buchner, P; Czejka, M; Dittrich, C; Mihola, E; Sahmanovic, A; Steininger, T | 1 |
| Baek, IH; Kim, MS; Kwon, KI; Lee, BY | 1 |
| Fukuda, S; Furuya, T; Hazama, S; Kawaoka, T; Nishimura, T; Oka, M; Ozasa, H; Shimizu, R; Yoshino, S | 1 |
| Araki, A; Eto, R; Hazama, S; Hinoda, Y; Kanekiyo, S; Kondo, H; Nagashima, A; Oka, M; Okayama, N; Shimizu, R; Uchiyama, T; Yamamoto, T; Yoshida, S; Yoshino, S | 1 |
| Baba, K; Eishi, Y; Fukamachi, H; Funasaka, C; Inokuchi, M; Jang, SJ; Kato, K; Kawachi, H; Kim, JH; Kim, MJ; Kim, WH; Kojima, K; Park, YS; Seol, HS; Shimada, S; Yook, JH; Yuasa, Y | 1 |
| Albain, KS; Blanke, CD; Coleman, D; Ely, B; Gold, PJ; Gotay, C; Lenz, HJ; Louie, SG; Raghavan, D; Shields, AF | 1 |
| Abe, H; Edamatsu, T; Fujieda, A; Fujioka, M; Mekata, E; Murata, S; Naka, S; Shimizu, T; Shiomi, H; Sonoda, H; Tani, T; Umeda, T; Wada, T; Yamamoto, H | 1 |
| Chang, HM; Jang, SJ; Jung, HY; Kang, YK; Kim, BS; Kim, JH; Kim, TW; Lee, JL; Lee, YJ; Park, YS; Ryu, MH; Yang, DH; Yoo, C; Yook, JH; Zang, DY | 1 |
| Cass, CE; Damaraju, VL; Kuzma, M; Mowles, D; Sawyer, MB; Wilson, M | 1 |
| Gao, Q; Liu, J; Liu, Y; Wang, QW; Ye, DJ; Zhang, JM | 1 |
| Czejka, M; Dittrich, C; Gintersdorfer, S; Kitzmueller, M; Lichtneckert, M; Neudorfer, C; Poxhofer, M; Schreiber, V | 1 |
| Buchner, P; Czejka, M; Farkouh, A; Georgopoulos, A; Gruenberger, B; Scheithauer, W; Schueller, J | 1 |
| Anthony, J; Dakshinamurthy, S; Gopal, D; Manambrakat, V; Padinjattayil, DS; Peter Dhassiah, M; Ramalingam, K; Rangamaran, VR; Shivasankarasubbiah, KT; Thilagam, ML; Thirunavukkarasu, S; Valsalan, VN | 1 |
| Han, J; Kim, JH; Kim, JS; Kumar, R; Lim, HJ; Lim, JY; Ren, WX | 1 |
| Bae, KS; Cho, JM; Choi, HJ; Go, SI; Kang, MH; Kim, DC; Kim, HG; Kim, MJ; Lee, JH; Lee, US; Lee, WS | 1 |
| Chen, Q; Li, H; Lin, JM; Wu, J; Zhang, J | 1 |
| Chen, X; Dai, X; Deng, P; Ding, L; Ji, C; Zhong, D | 1 |
| Liu, Q; Wang, Q; Ye, D; Zhang, J | 1 |
| Baken, BC; Erlinghagen, V; Fuhr, U; Kubeš, V; Novotný, V; Peroutka, R; Queckenberg, C; Van Os, SH; Wargenau, M | 1 |
| Amano, H; Fukuda, T; Kawashima, M; Nakahara, M; Noriyuki, T; Ono, N; Saito, R; Sasada, T; Takei, D; Takemoto, Y; Yamaki, M; Yoshida, M | 1 |
| Hwang, SH; Kim, SG | 1 |
| Kitade, Y; Kitamura, Y; Kito, S; Nagaoka, K; Nakashima, R; Tanaka, K | 1 |
| Doki, Y; Fujita, J; Fujitani, K; Fujiwara, Y; Hirao, M; Imamura, H; Kimura, Y; Moon, JH; Mori, M; Takiguchi, S; Tamura, S; Yano, M | 1 |
| Chionh, F; Lau, D; Price, T; Tebbutt, N; Yeung, Y | 1 |
| Ito, Y; Kobuchi, S; Sakaeda, T; Yazaki, Y | 1 |
| Acosta, J; Feldser, DM; Wang, W | 1 |
| Fujita, KI; Ishida, H; Ishikawa, F; Kubota, Y; Ohkuma, R; Sasaki, Y; Sekido, M; Shibanuma, M; Takahashi, T; Tsunoda, T | 1 |
| He, S; Jiang, Y; Pu, K; Xie, C | 1 |
| Beijnen, JH; Cats, A; de Vries, N; Deenen, MJ; Huitema, ADR; Jacobs, BAW; Joerger, M; Meulendijks, D; Rosing, H; Schellens, JHM | 1 |
| Bao, L; Chen, Z; He, H; Huang, Y; Li, P; Xiao, G; Xu, L; Yang, R; Zhang, Y | 1 |
| Cai, Z; Lin, X; Liu, X; Ma, Y; Wu, M; Xue, F | 1 |
| Bartfeld, S; Bauer, M; Cheng, PF; Dobrovolna, J; Dohlman, A; Gall, AA; Hurwitz, R; Jacobs, M; Janscak, P; Lampart, S; Levesque, MP; Meyer, TF; Mihai, AI; Müller, A; Nascakova, Z; Pfannkuch, L; Salama, NR; Shen, X; Töpfer, A; Weber, A | 1 |
| Li, K; Liu, J; Si, S; Xu, J; Xue, P | 1 |
| Jiang, WL; Li, CY; Mao, GJ; Tan, M; Tan, ZK; Wang, WX | 1 |
30 review(s) available for doxifluridine and floxuridine
| Article | Year |
|---|---|
[A comparative study with 5'-DFUR alone or in combination with tamoxifen (TAM) or medroxyprogesterone acetate (MPA) for advanced or recurrent breast cancer].
Topics: Adult; Aged; Breast Neoplasms; Drug Administration Schedule; Drug Therapy, Combination; Female; Floxuridine; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Recurrence, Local; Tamoxifen | 1992 |
Doxifluridine in advanced colorectal cancer.
Topics: Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Isomerism | 1991 |
New potential treatment modalities for disseminated prostatic cancer.
Topics: Androgen Antagonists; Animals; Antibiotics, Antineoplastic; Antibodies, Monoclonal; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma; Castration; Combined Modality Therapy; Cyclophosphamide; Floxuridine; Folic Acid Antagonists; Hormones; Humans; Interferons; Isomerism; Male; Methotrexate; Naphthacenes; Nitrosourea Compounds; Organoplatinum Compounds; Prostatic Neoplasms; Thymus Hormones; Tumor Stem Cell Assay | 1984 |
[Peritoneal dissemination of cecal cancer disappearing in a patient taking 5'-DFUR for 3 years].
Topics: Adenocarcinoma; Antibiotics, Antineoplastic; Cecal Neoplasms; Female; Floxuridine; Humans; Middle Aged; Neoplasms, Second Primary; Ovarian Neoplasms; Peritoneal Neoplasms; Remission Induction | 1994 |
[Process of making a protocol for advanced gastric cancer chemotherapy--using 5'-DFUR+CDDP as an example].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Protocols; Drug Administration Schedule; Floxuridine; Humans; Quality of Life; Stomach Neoplasms; Survival Rate | 1993 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Neoplasms, Experimental; Rectal Neoplasms; Remission Induction; Stomach Neoplasms; Survival Rate | 1996 |
[Treatment strategy for recurrent breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Aromatase Inhibitors; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Epirubicin; Female; Floxuridine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Infusions, Intravenous; Medroxyprogesterone Acetate; Neoplasm Recurrence, Local; Palliative Care; Survival Rate; Tamoxifen | 1998 |
[PyNPase expression and cancer progression in the colorectum].
Topics: Antineoplastic Agents; Biomarkers, Tumor; Blotting, Western; Colorectal Neoplasms; Disease Progression; Floxuridine; Humans; Macrophages; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases | 1998 |
[Gastrointestinal cancer and oral anticancer agents].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Camptothecin; Drug Combinations; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Irinotecan; Organoplatinum Compounds; Oxonic Acid; Prodrugs; Pyridines; Tegafur; Uracil | 1999 |
[Recent development of oral anti-cancer drugs for breast cancer].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Breast Neoplasms; Clinical Trials, Phase II as Topic; Cyclophosphamide; Drug Administration Schedule; Fadrozole; Female; Floxuridine; Fluorouracil; Gonadotropin-Releasing Hormone; Humans; Medroxyprogesterone Acetate; Survival Rate; Tamoxifen; Toremifene | 1999 |
[Oral fluoropyrimidines in oncology].
Topics: Administration, Oral; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Clinical Trials as Topic; Combined Modality Therapy; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Neoplasm Recurrence, Local; Neoplasms; Tegafur; Time Factors; Uracil | 1998 |
[A case report of gastric carcinoma with complete remission of paraaortic lymph node metastasis by 5'-DFUR and MMC administration after resection of primary tumor].
Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Combined Modality Therapy; Floxuridine; Gastrectomy; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Remission Induction; Stomach Neoplasms | 1999 |
[New drugs in gastrointestinal oncology. Current status and future directions].
Topics: Antineoplastic Agents; Camptothecin; Capecitabine; Deoxycytidine; Docetaxel; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gemcitabine; Humans; Irinotecan; Organoplatinum Compounds; Oxaliplatin; Paclitaxel; Quinazolines; Taxoids; Tegafur; Thiophenes; Vinblastine; Vinorelbine | 1999 |
New anticancer agents.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Agents; Cyclin-Dependent Kinases; DNA; Floxuridine; Humans; Microtubules; Organoplatinum Compounds; Signal Transduction; Thymidylate Synthase; Uracil | 1999 |
[Thymidine phosphorylase as a prognostic factors of breast cancers].
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Disease-Free Survival; Female; Floxuridine; Humans; Lymphatic Metastasis; Predictive Value of Tests; Prognosis; Thymidine Phosphorylase | 2000 |
[Oral cancer chemotherapy in the clinic].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Hematologic Neoplasms; Humans; Melphalan; Quality of Life; Tamoxifen; Tegafur; Uracil | 2000 |
Adrenalectomy for solitary adrenal metastasis from colorectal carcinoma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Pneumonectomy; Rectal Neoplasms; Tegafur; Uracil | 2000 |
Survival benefits of adjuvant chemotherapy with oral doxifluridine (5'-DFUR) following radiotherapy in patients with unresectable pancreatic cancer.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Middle Aged; Pancreatic Neoplasms; Prognosis; Radiotherapy Dosage; Retrospective Studies; Survivors | 2001 |
[Chemotherapy of gastric cancer--a review of clinical trials in Japan].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Clinical Trials as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Drug Administration Schedule; Drug Combinations; Floxuridine; Humans; Japan; Methotrexate; Mitomycin; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2002 |
[Doxifluridine for treatment of colorectal cancer].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Pentosyltransferases; Prodrugs; Prognosis; Pyrimidine Phosphorylases; Thymidine Phosphorylase | 2003 |
[A case of 10-year survival after combination chemotherapy of 5'-deoxy-5-fluorouridine and cisplatin and adjuvant surgery for gastric cancer with liver metastasis].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Gastrectomy; Humans; Liver Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Neoplasm Staging; Splenectomy; Stomach Neoplasms; Survivors | 2004 |
Uridine phosophorylase: an important enzyme in pyrimidine metabolism and fluoropyrimidine activation.
Topics: Animals; Antimetabolites, Antineoplastic; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Humans; Neoplasms; Pyrimidines; Uridine; Uridine Phosphorylase | 2004 |
[Effectiveness of chemoradiotherapy for three cases of squamous cell anal carcinoma].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Carcinoma, Squamous Cell; Chemotherapy, Adjuvant; Cisplatin; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymphatic Metastasis; Middle Aged; Radiotherapy, Adjuvant; Tegafur; Uracil | 2004 |
[Current combination chemotherapy containing paclitaxel for advanced, recurrent gastric cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Oxonic Acid; Paclitaxel; Pyridines; Quality of Life; Stomach Neoplasms; Tegafur | 2004 |
Uridine phosphorylase in breast cancer: a new prognostic factor?
Topics: Animals; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Breast Neoplasms; Capecitabine; Deoxycytidine; Enzyme Induction; Female; Floxuridine; Fluorouracil; Gene Expression Regulation; Humans; Mice; Prodrugs; Prognosis; Pyrimidinones; Treatment Outcome; Uridine Phosphorylase | 2006 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
Chronic myeloid leukemia following chemotherapy with 5'-deoxy-5-fluorouridine for gastric cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Floxuridine; Humans; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Male; Neoplasms, Second Primary; Stomach Neoplasms; Time Factors | 2008 |
Therapeutic usefulness of postoperative adjuvant chemotherapy with Tegafur-Uracil (UFT) in patients with breast cancer: focus on the results of clinical studies in Japan.
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Clinical Trials as Topic; Deoxycytidine; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Japan; Methotrexate; Oxonic Acid; Tegafur; Uracil | 2010 |
Oral versus intravenous fluoropyrimidines for colorectal cancer.
Topics: Administration, Oral; Adult; Antineoplastic Agents; Camptothecin; Capecitabine; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Irinotecan; Male; Neoadjuvant Therapy; Organoplatinum Compounds; Palliative Care; Pyridines; Pyrimidines; Randomized Controlled Trials as Topic; Tegafur; Uracil | 2017 |
Off and back-on again: a tumor suppressor's tale.
Topics: Alleles; Animals; CRISPR-Cas Systems; Floxuridine; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Genetic Engineering; Genetic Vectors; Humans; Mice; Mice, Transgenic; Neoplasms, Experimental; Recombinases; RNA Interference | 2018 |
124 trial(s) available for doxifluridine and floxuridine
| Article | Year |
|---|---|
[Co-operative clinical evaluation of 5'-DFUR tablets for breast cancer at 31 institutions].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Middle Aged; Tablets | 1992 |
[Combination therapy of doxifluridine (5'-DFUR) + cyclophosphamide (CPA) + tamoxifen (TAM) for advanced or recurrent breast cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5'-DFUR with Other Drugs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Middle Aged; Soft Tissue Neoplasms; Tamoxifen | 1992 |
[Multi-institutional trials of radiation and Furtulon combination therapy for malignant tumors].
Topics: Administration, Oral; Antineoplastic Agents; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Neoplasms; Radiotherapy Dosage | 1992 |
[Clinical trial of 5'-DFUR against various malignant tumors].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasms; Stomach Neoplasms | 1985 |
[Clinical trial of 5'-deoxy-5-fluorouridine (5'-DFUR) in advanced cancer patients].
Topics: Aged; Antineoplastic Agents; Breast Neoplasms; Clinical Trials as Topic; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Stomach Neoplasms | 1985 |
[Clinical trial of a new fluorinated pyrimidine, 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Adult; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Clinical Trials as Topic; Drug Administration Schedule; Female; Floxuridine; Humans; Middle Aged; Neoplasm Recurrence, Local | 1986 |
Wernicke-Korsakoff-like syndrome in patients with colorectal carcinoma treated with high-dose doxifluridine (5'-dFUrd).
Topics: Adult; Aged; Brain Diseases; Carcinoid Tumor; Carcinoma; Cerebellar Diseases; Colonic Neoplasms; Electroencephalography; Electromyography; Female; Floxuridine; Humans; Male; Middle Aged; Nervous System Diseases; Neural Conduction; Neurologic Examination; Rectal Neoplasms; Time Factors; Wernicke Encephalopathy | 1986 |
Phase I/II tolerability/pharmacokinetic study with one-hour intravenous infusion of doxifluiridine (5'-dFUrd) 3 g/m2 VS 5 g/m2 QD x 5 per month.
Topics: Adenocarcinoma; Antineoplastic Agents; Cecal Neoplasms; Colonic Neoplasms; Drug Evaluation; Drug Tolerance; Female; Floxuridine; Humans; Infusions, Intravenous; Male; Middle Aged; Random Allocation; Rectal Neoplasms; Sigmoid Neoplasms; Time Factors | 1986 |
[Randomized comparison of continuous and intermittent oral administration of 5'-deoxy-5-fluorouridine in the treatment of advanced gastric cancer; a phase II trial by the Multi-institutional Cooperative Study Group].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Male; Middle Aged; Stomach Neoplasms | 1987 |
A randomized comparison of doxifluridine and fluorouracil in colorectal carcinoma.
Topics: Adenocarcinoma; Antineoplastic Agents; Clinical Trials as Topic; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Random Allocation; Rectal Neoplasms | 1988 |
The pharmacokinetics of doxifluridine and 5-fluorouracil after single intravenous infusions of doxifluridine to patients with colorectal cancer.
Topics: Adult; Aged; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Half-Life; Humans; Infusions, Intravenous; Male; Middle Aged | 1988 |
Clinical trial of doxifluridine in the treatment of primary hepatocellular carcinoma.
Topics: Aged; Carcinoma, Hepatocellular; Clinical Trials as Topic; Female; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Taiwan | 1986 |
[Combination therapy of high dose 5'-DFUR+MMC for advanced or recurrent gastric cancer. 5'-DFUR Joint Research Group in the Osaka District for Gastric Cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Diarrhea; Drug Administration Schedule; Female; Floxuridine; Humans; Injections, Intravenous; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Stomach Neoplasms; Survival Analysis | 1995 |
Doxifluridine and leucovorin: an oral treatment combination in advanced colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Gastrointestinal Diseases; Humans; Leucovorin; Male; Middle Aged; Survival Rate; Treatment Outcome | 1995 |
[Effect of 5'-deoxy-5-fluorouridine (5'-DFUR) on the activity of pyrimidine nucleoside phosphorylase (pyNPase) in normal and tumor tissues of human stomach].
Topics: Antineoplastic Agents; Female; Floxuridine; Humans; Interleukin-1; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Stomach; Stomach Neoplasms | 1995 |
[The effect of combination treatment consisted of 5'-deoxy-5-fluorouridine and medroxyprogesterone acetate for recurrent breast cancer patient].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Middle Aged; Soft Tissue Neoplasms | 1995 |
Oral doxifluridine in elderly patients with metastatic colorectal cancer: a multicenter phase II study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Diarrhea; Feasibility Studies; Female; Floxuridine; Humans; Italy; Male; Neoplasm Metastasis; Remission Induction | 1994 |
[5-FU concentrations in the blood and tumor tissue after 5'-DFUR or UFT administration in the patients with uterine cervical cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Middle Aged; Tegafur; Uracil; Uterine Cervical Neoplasms | 1995 |
[Pharmacological study of 5'-DFUR oral administration and the clinical responses against gastrointestinal carcinoma].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pancreatic Neoplasms; Stomach Neoplasms; Treatment Outcome | 1995 |
[Combination with intra-hepatic arterial infusion of low-dose cisplatin and oral administration of high-dose doxyfluridine in patients with liver metastases of gastric cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Stomach Neoplasms | 1994 |
[Hepatic arterial infusion after hepatectomy for liver metastases of colorectal carcinoma to prevent residual hepatic recurrence].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Hepatectomy; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm, Residual; Prognosis | 1994 |
[Adjuvant chemo-endocrine chemotherapy with gastrin antagonist after resection of liver metastasis in colorectal cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Doxorubicin; Female; Floxuridine; Gastrins; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Proglumide | 1994 |
[A study of preoperative administration of 5'-DFUR in patients with colo-rectal cancer].
Topics: Administration, Oral; Antineoplastic Agents; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Lymphatic Metastasis; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1994 |
[Randomized controlled study of sequential methotrexate and 5-fluorouracil therapy with or without 5'-deoxy-5-fluorouridine against advanced gastrointestinal cancer. Hirosaki Cooperative Study Group for Cancer Chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Leucovorin; Male; Methotrexate; Middle Aged; Quality of Life; Survival Analysis | 1994 |
A phase I safety study of doxifluridine and interferon-alpha-2a in patients with advanced neoplastic disease.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Male; Middle Aged; Neoplasms; Recombinant Proteins | 1993 |
[Evaluation of combination chemotherapy for advanced gastric carcinoma as a neoadjuvant chemotherapy with CDDP, MMC, etoposide and 5'-DFUR].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Etoposide; Female; Floxuridine; Humans; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Stomach Neoplasms | 1994 |
[Study of 5'-DFUR treatment as postoperative adjuvant chemotherapy for stomach and colorectal cancer. Tokai GATS Group (pilot study)].
Topics: Administration, Oral; Antineoplastic Agents; Chemotherapy, Adjuvant; Colorectal Neoplasms; Diarrhea; Drug Administration Schedule; Floxuridine; Humans; Mitomycin; Pilot Projects; Postoperative Care; Remission Induction; Stomach Neoplasms; Survival Rate | 1994 |
[Sequential methotrexate/5-fluorouracil therapy with 5'-deoxy-5-fluorouridine against advanced gastric cancer: comparison between bolus injection and drip infusion of 5-fluorouracil administration. Hirosaki Cooperative Study Group for Cancer Chemotherapy]
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Alopecia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Injections, Intravenous; Leukopenia; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms | 1994 |
A phase I-II study of oral doxifluridine plus radiotherapy in radiosensitive tumors of the pelvic region.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Combined Modality Therapy; Female; Floxuridine; Humans; Male; Middle Aged; Pelvic Neoplasms; Prodrugs; Radiation Tolerance | 1993 |
A phase II study of combination therapy with 5'-deoxy-5-fluorouridine and cisplatin in the treatment of advanced gastric cancer with primary foci.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Floxuridine; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Treatment Outcome | 1993 |
Phase II study of an oral combination of doxifluridine, prednimustine and idarubicin (FUPRIDA) for first line treatment of advanced breast cancer.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Floxuridine; Humans; Idarubicin; Middle Aged; Prednimustine | 1993 |
Prospective randomised trial comparing fluorouracil versus doxifluridine for the treatment of advanced colorectal cancer.
Topics: Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leukopenia; Male; Middle Aged; Prospective Studies | 1993 |
[Influence of intratumor administration of OK-432 on the tumor selectivity of 5'-DFUR].
Topics: Antineoplastic Agents; Floxuridine; Humans; Injections, Intralesional; Isomerism; Pentosyltransferases; Picibanil; Prodrugs; Pyrimidine Phosphorylases; Stomach Neoplasms | 1995 |
[A randomized controlled study of maintenance therapy with (2"R)-4'-O-tetrahydropyranyladriamycin for advanced and recurrent breast cancer. Clinical Study Group of THP for Breast Cancer in Japan].
Topics: Adult; Alopecia; Anorexia; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Humans; Japan; Middle Aged; Nausea; Neoplasm Recurrence, Local; Survival Analysis; Vomiting | 1996 |
[Survival and changes of clinical laboratory data in phase II study with 5'-DFUR].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Blood Cell Count; Breast Neoplasms; Cachexia; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Neoplasms, Experimental; Rectal Neoplasms; Remission Induction; Stomach Neoplasms; Survival Rate | 1996 |
Effect of low dose cyclophosphamide on the synthesis of acute phase protein and its significance for cancer chemotherapy.
Topics: Acute-Phase Proteins; Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Cyclophosphamide; Floxuridine; Humans; Middle Aged; Neoplasm Proteins | 1996 |
Randomized phase II noncomparative trial of oral and intravenous doxifluridine plus levo-leucovorin in untreated patients with advanced colorectal carcinoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antidotes; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Survival Rate | 1996 |
Phase II study of oral doxifluridine in elderly patients with advanced non-small-cell lung cancer.
Topics: Administration, Oral; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Diarrhea; Drug Administration Schedule; Drug Tolerance; Feasibility Studies; Female; Floxuridine; Home Care Services; Humans; Isomerism; Lung Neoplasms; Male; Remission Induction | 1996 |
[Significance of 5'-deoxy-5-fluorouridine (5'-DFUR) administration before surgery for advanced gastric and colonic cancers--activity of pyrimidine nucleoside phosphorylase (PyNPase) and serum immunosuppressive acidic protein (IAP)].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Immunosuppressive Agents; Male; Middle Aged; Neoplasm Proteins; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases; Stomach Neoplasms | 1996 |
A prospective randomized administration of 5'-deoxy-5-fluorouridine as adjuvant chemotherapy for hepatocellular carcinoma treated with transcatheter arterial chemoembolization.
Topics: Adult; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Combined Modality Therapy; Embolization, Therapeutic; Female; Floxuridine; Humans; Male; Middle Aged; Multivariate Analysis; Prospective Studies; Survival Rate; Treatment Outcome | 1997 |
[The alteration of PyNPase activity in breast cancers due to preoperative oral administration of 5'-DFUR].
Topics: Administration, Oral; Adult; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Humans; Middle Aged; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1997 |
Doxifluridine in colorectal cancer patients resistant to 5-fluorouracil (5-FU) containing regimens.
Topics: Administration, Oral; Adult; Aged; Antidotes; Antimetabolites, Antineoplastic; Antineoplastic Agents; Colorectal Neoplasms; Drug Resistance, Neoplasm; Drug Therapy, Combination; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Liver Neoplasms; Lung Neoplasms; Male; Middle Aged; Tomography, X-Ray Computed | 1997 |
A combination chemoendocrine therapy of mitoxantrone, doxifluridine, and medroxyprogesterone acetate for anthracycline-resistant advanced breast cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Medroxyprogesterone; Middle Aged; Mitoxantrone | 1998 |
[Correlation between pyrimidine nucleoside phosphorylase (PyNPase)/thymidine phosphorylase/platelet-derived endothelial cell growth factor and histological prognostic factor, and influence of 5'-deoxy-5-fluorouridine (5'-DFUR) administration on PyNPase ac
Topics: Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Middle Aged; Neoplasm Proteins; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases; Stomach Neoplasms; Thymidine Phosphorylase | 1998 |
[Effect of 5'-DFUR used concurrently in radiotherapy and immunotherapy uterine cervical cancer--pilot study. Study of 5'-DFUR for Uterine Cervical Cancer].
Topics: Adjuvants, Immunologic; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Immunotherapy; Middle Aged; Pilot Projects; Sizofiran; Uterine Cervical Neoplasms | 1998 |
[Correlation between pyrimidine nucleoside phosphorylase (PyNPase)/platelet-derived endothelial cell growth factor and histological prognostic factor, and influences of 5'-deoxy-5-fluorouridine (5'-DFUR) administration on PyNPase levels. 5'-DFUR Joint Res
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Enzyme-Linked Immunosorbent Assay; Floxuridine; Humans; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases; Stomach Neoplasms; Thymidine Phosphorylase | 1998 |
Oral doxifluridine plus levoleucovorin in elderly patients with advanced breast cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antidotes; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Methotrexate; Neoplasm Staging | 1998 |
[Comparative study of 5'-DFUR administration in patients with elderly cancer].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Colonic Neoplasms; Female; Floxuridine; Humans; Male; Pilot Projects; Stomach Neoplasms | 1998 |
Results of leucovorin and doxifluridine oral regimen in the treatment of metastatic colorectal cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Female; Floxuridine; Humans; Italy; Leucovorin; Male; Middle Aged; Treatment Outcome | 1998 |
[Effect of CDDP/5'-DFUR combination chemotherapy for advanced or recurrent gastric cancer].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Child; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis; Male; Middle Aged; Stomach Neoplasms; Survival Analysis | 1998 |
Combination chemotherapy of oral 5'-deoxy-5-fluorouridine and cisplatin in advanced gastric cancer: a phase II study.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Intravenous; Male; Middle Aged; Stomach Neoplasms | 1998 |
[Therapeutic efficacy of pirarubicin cyclophosphamide and doxifluridine in advanced and metastatic breast cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Leukopenia; Middle Aged; Neoplasm Recurrence, Local | 1999 |
[Antitumor effect of 5'-DFUR and PyNPase activity in colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Colorectal Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1999 |
[Usefulness of low dose 5'-DFUR (5'-deoxy-5-fluorouridine) for advanced or recurrent breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local | 1999 |
Drug-induced apoptosis and p53, BCL-2 and BAX expression in breast cancer tissues in vivo and in fibroblast cells in vitro.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Breast Neoplasms; Cell Division; Drug Screening Assays, Antitumor; Female; Fibroblasts; Flow Cytometry; Floxuridine; Humans; Immunoenzyme Techniques; Immunohistochemistry; Middle Aged; Prodrugs; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Tumor Cells, Cultured; Tumor Suppressor Protein p53 | 1999 |
[Two regimens of combined 5'-deoxy-5-fluorouridine and cisplatin showing different dose intensities--investigation based on relative performances].
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Dose-Response Relationship, Drug; Drug Administration Schedule; Floxuridine; Humans; Stomach Neoplasms; Survival Analysis | 1999 |
Selective augmentations of intratumoral 5-fluorouracil concentration by local immunotherapy with OK-432 and fibrinogen.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Chemotherapy, Adjuvant; Colon; Colorectal Neoplasms; Combined Modality Therapy; Drug Synergism; Female; Fibrinogen; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoadjuvant Therapy; Picibanil; Rectum | 2000 |
A phase III randomized study comparing oral doxifluridine and oral 5-fluorouracil after curative resection of gastric cancer.
Topics: Administration, Oral; Adult; Aged; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms; Time Factors | 2000 |
[Clinical efficacy of low-dose weekly docetaxel combined with oral 5'-deoxy-5-fluorouridine (5'-DFUR) in advanced or metastatic breast cancer: a pilot trial].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Floxuridine; Humans; Middle Aged; Neoplasm Metastasis; Paclitaxel; Pilot Projects; Taxoids | 2000 |
[Long-term outcome of preoperative chemotherapy with 5'-deoxy-5-fluorouridine (5'-DFUR) for gastric cancer].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Female; Floxuridine; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Invasiveness; Stomach Neoplasms; Survival Rate; Treatment Outcome | 2000 |
[5'-DFUR chemoprophylaxis in superficial bladder cancer. Kanagawa Urology 5'-DFUR Study Group].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Floxuridine; Humans; Isomerism; Male; Middle Aged; Neoplasm Recurrence, Local; Prospective Studies; Urinary Bladder Neoplasms | 2000 |
A prospective randomized trial comparing intravenous 5-fluorouracil and oral doxifluridine as postoperative adjuvant treatment for advanced rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Postoperative Period; Prospective Studies; Quality of Life; Rectal Neoplasms; Treatment Outcome | 2000 |
Phase I clinical trial of oral furtulon and combined hepatic arterial chemoembolization and radiotherapy in unresectable primary liver cancers, including clinicopathologic study.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemoembolization, Therapeutic; Combined Modality Therapy; Female; Floxuridine; Hepatic Artery; Humans; Liver Neoplasms; Male; Middle Aged; Radiation-Sensitizing Agents | 2000 |
Oral doxifluridine in advanced hepatocellular carcinoma: A phase II study.
Topics: Administration, Oral; Aged; Ambulatory Care; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Survival Analysis | 2000 |
5'-deoxy-5-fluorouridine, medroxyprogestrone acetate and mitoxantrone hydrochloride for advanced or recurrent breast cancer.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Evaluation; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Salvage Therapy; Time Factors | 2001 |
[Clinical evaluation of effects and improvement in quality of life from palliative therapy of combination chemotherapy with Furtulon and consecutive low-dose cisplatin in cases of unresectable advanced gastrointestinal carcinoma].
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Floxuridine; Gastrointestinal Neoplasms; Humans; Male; Middle Aged; Palliative Care; Quality of Life | 2001 |
Intravenous 5-fluorouracil versus oral doxifluridine as preoperative concurrent chemoradiation for locally advanced rectal cancer: prospective randomized trials.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Prospective Studies; Quality of Life; Rectal Neoplasms | 2001 |
[Preoperative chemotherapy for advanced colorectal carcinomas--comparison of histological effect between 5'-DFUR + leucovorin tablet and 5'-DFUR alone].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Leucovorin; Lymphatic Metastasis; Male; Middle Aged; Preoperative Care; Tablets | 2001 |
Preoperative chemoradiotherapy with oral doxifluridine plus low-dose oral leucovorin in unresectable primary rectal cancer.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Diarrhea; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Preoperative Care; Radiotherapy; Rectal Neoplasms; Thrombocytopenia | 2001 |
[A phase I study of docetaxel (TXT) and doxifluridine (5'-DFUR) combination therapy in patients with advanced and recurrent breast cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Intravenous; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Taxoids | 2001 |
[The efficacy of combination chemotherapy of 5'-deoxy-5-fluorouridine (5'-DFUR), cyclophosphamide (CPA) and medroxyprogesterone acetate (MPA) for bone metastasis in breast cancer patients].
Topics: Adult; Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Pain, Intractable; Palliative Care; Quality of Life | 2001 |
Variations in 5-fluorouracil concentrations of colorectal tissues as compared with dihydropyrimidine dehydrogenase (DPD) enzyme activities and DPD messenger RNA levels.
Topics: Antimetabolites, Antineoplastic; Colon; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Oxidoreductases; Rectum; RNA, Messenger | 2001 |
[Combination chemotherapy of doxifluridine plus mitomycin C for colorectal lung metastasis--phase II study].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Survival Rate | 2001 |
[Adjuvant chemotherapy after curative resection for gastric cancer-5'-DFUR + cisplatin vs 5'-DFUR].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Gastrectomy; Humans; Male; Middle Aged; Prospective Studies; Stomach Neoplasms | 2002 |
The effect of adjuvant 5'-deoxy-5-fluorouridine in early stage breast cancer patients: results from a multicenter randomized controlled trial.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Disease-Free Survival; Female; Floxuridine; Humans; Middle Aged; Recurrence; Time Factors; Treatment Outcome | 2002 |
A phase II study of doxifluridine in elderly patients with advanced gastric cancer: the Japan Clinical Oncology Group Study (JCOG 9410).
Topics: Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Registries; Stomach Neoplasms; Survival Rate | 2002 |
Prognostic and predictive value of thymidine phosphorylase activity in early-stage breast cancer patients.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Humans; Japan; Middle Aged; Predictive Value of Tests; Prognosis; Randomized Controlled Trials as Topic; Retrospective Studies; Stromal Cells; Survival Analysis; Thymidine Phosphorylase; Tumor Cells, Cultured | 2002 |
Preoperative chemoradiation in patients with resectable rectal cancer: results on tumor response.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Staging; Rectal Neoplasms; Treatment Outcome | 2002 |
[Assessment of complications in a randomized controlled study on multimodality therapy for patients following breast-conserving surgery: Kansai Breast Cancer Radiotherapy Research Group (5'-KBR)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Mastectomy, Segmental; Radiotherapy; Tamoxifen | 2002 |
Oral doxifluridine plus leucovorin in metastatic colorectal cancer: randomized phase II trial with intravenous 5-fluorouracil plus leucovorin.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis; Survival Analysis | 2003 |
Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged | 2003 |
Randomized controlled trial comparing oral doxifluridine plus oral cyclophosphamide with doxifluridine alone in women with node-positive breast cancer after primary surgery.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Humans; Japan; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Odds Ratio; Survival Analysis; Treatment Outcome | 2003 |
A randomized controlled trial of postoperative adjuvant immunochemotherapy for colorectal cancer with oral medicines.
Topics: Adjuvants, Immunologic; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunosuppressive Agents; Lymphatic Metastasis; Male; Middle Aged; Prognosis; Recurrence; Time Factors; Treatment Outcome | 2003 |
[Prevention and treatment of bladder tumors recurrence with furtulon].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Follow-Up Studies; Humans; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Treatment Outcome; Urinary Bladder Neoplasms | 2000 |
The potential for oral combination chemotherapy of 5'-deoxy-5-fluorouridine, a 5-FU prodrug, and cyclophosphamide for metastatic breast cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Floxuridine; Humans; Middle Aged; Neoplasm Metastasis; Prodrugs; Survival Rate; Treatment Outcome | 2003 |
[Immunotherapy of metastatic renal cell carcinoma: report of 28 cases].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Combined Modality Therapy; Drug Therapy, Combination; Female; Floxuridine; Humans; Immunotherapy; Injections, Subcutaneous; Interferons; Interleukin-2; Kidney Neoplasms; Male; Middle Aged; Neoplasm Metastasis; Treatment Outcome | 2004 |
The ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase in tumour tissues of patients with metastatic gastric cancer is predictive of the clinical response to 5'-deoxy-5-fluorouridine.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Enzyme-Linked Immunosorbent Assay; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Prospective Studies; Stomach Neoplasms; Survival Analysis; Thymidine Phosphorylase; Treatment Outcome | 2004 |
Gene expression profiles of colorectal carcinoma in response to neo-adjuvant chemotherapy.
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoma; Chemotherapy, Adjuvant; Colorectal Neoplasms; Drug Interactions; Female; Floxuridine; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genes, fos; Humans; Infusions, Intravenous; Irinotecan; Male; Middle Aged; Neoadjuvant Therapy; Treatment Outcome; Up-Regulation | 2004 |
The efficacy of long-term oral chemotherapy with 5'-deoxy-5-fluorouridine and cyclophosphamide for recurrent breast cancer.
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Pain; Palliative Care; Quality of Life | 2004 |
A prospective randomized study of gemcitabine with doxifluridine versus paclitaxel with doxifluridine in concurrent chemoradiotherapy for locally advanced pancreatic cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Female; Floxuridine; Gemcitabine; Humans; Male; Middle Aged; Paclitaxel; Pancreatic Neoplasms; Radiotherapy Dosage | 2004 |
Novel prophylactic effect of doxifluridine in superficial bladder cancer.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Carcinoma, Transitional Cell; Cystectomy; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Follow-Up Studies; Humans; Immunohistochemistry; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Probability; Proportional Hazards Models; Prospective Studies; Reference Values; Risk Assessment; Survival Analysis; Treatment Outcome; Urinary Bladder Neoplasms | 2004 |
Sequential treatment with irinotecan and doxifluridine: optimal dosing schedule in murine models and in a phase I study for metastatic colorectal cancer.
Topics: Adult; Aged; Animals; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Diarrhea; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Maximum Tolerated Dose; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Transplantation, Heterologous | 2005 |
A phase I study of doxifluridine combined with weekly paclitaxel for metastatic gastric cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Maximum Tolerated Dose; Middle Aged; Paclitaxel; Stomach Neoplasms | 2005 |
Pharmacokinetic and pharmacodynamic comparison of fluoropyrimidine derivatives, capecitabine and 5'-deoxy-5-fluorouridine (5'-DFUR).
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Middle Aged | 2005 |
[Bi-weekly chemotherapy with medium-dose docetaxel for advanced and recurrent breast cancers (The 15th study of Keiji Breast Cancer Study Group)].
Topics: Adult; Aged; Alopecia; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Bone Marrow; Breast Neoplasms; Docetaxel; Drug Administration Schedule; Female; Floxuridine; Humans; Middle Aged; Neoplasm Recurrence, Local; Taxoids | 2005 |
Pharmacokinetic modelling of 5-FU production from capecitabine--a population study in 40 adult patients with metastatic cancer.
Topics: Adult; Aged; Algorithms; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Camptothecin; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Irinotecan; Middle Aged; Models, Biological; Molecular Structure; Neoplasm Metastasis; Neoplasms; Prodrugs; Sesquiterpenes | 2005 |
Apoptosis induced by preoperative oral 5'-DFUR administration in gastric adenocarcinoma and its mechanism of action.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Apoptosis Regulatory Proteins; Cell Proliferation; Disease Progression; Fas Ligand Protein; Female; Floxuridine; Gene Expression Regulation, Neoplastic; Humans; Immunohistochemistry; Male; Membrane Glycoproteins; Middle Aged; Prognosis; Proliferating Cell Nuclear Antigen; Stomach Neoplasms; Thymidine Phosphorylase; Tumor Necrosis Factors | 2006 |
Concurrent chemoradiotherapy with doxifluridine and paclitaxel for extrahepatic bile duct cancer.
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Extrahepatic; Combined Modality Therapy; Female; Floxuridine; Humans; Infusions, Intravenous; Male; Middle Aged; Paclitaxel; Survival Analysis; Treatment Outcome | 2006 |
[Evaluation of safety and efficacy for bi-weekly Docetaxel and 5'-DFUR combination therapy in patients with advanced or recurrent breast cancer--Phase I study].
Topics: Administration, Oral; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Docetaxel; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Maximum Tolerated Dose; Middle Aged; Neoplasm Recurrence, Local; Taxoids | 2006 |
Clinical usefulness of oral combination chemotherapy of 5'-deoxy-5-fluorouridine (5'-DFUR) and cyclophosphamide for metastatic breast cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Floxuridine; Humans; Middle Aged; Prospective Studies; Treatment Outcome | 2006 |
Docetaxel, low-dose estramustine, and doxifluridine in hormone-refractory metastatic prostate cancer.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Disease Progression; Docetaxel; Estramustine; Floxuridine; Granulocyte Colony-Stimulating Factor; Humans; Japan; Male; Middle Aged; Neutropenia; Prostate-Specific Antigen; Prostatic Neoplasms; Quality of Life; Survival Rate; Taxoids | 2008 |
A phase II study of irinotecan in combination with doxifluridine, an intermediate form of capecitabine, in patients with metastatic colorectal cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Hematologic Diseases; Humans; Irinotecan; Leukocyte Count; Male; Middle Aged; Neoplasm Metastasis; Sample Size; Survival Analysis | 2008 |
Pyrimidine nucleoside phosphorylase and dihydropyrimidine dihydrogenase activities as predictive factors for the efficacy of doxifluridine together with mitomycin C as adjuvant chemotherapy in primary colorectal cancer.
Topics: Adult; Aged; Antineoplastic Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Humans; Male; Middle Aged; Mitomycin; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases; Recurrence; Survival Analysis; Treatment Outcome | 2007 |
A clinical study of docetaxel with or without 5'DFUR as a second-line chemotherapy for advanced gastric cancer.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Female; Floxuridine; Humans; Male; Middle Aged; Pilot Projects; Prognosis; Stomach Neoplasms; Survival Rate; Taxoids | 2007 |
A phase I safety, tolerability, and pharmacokinetic study of enzastaurin combined with capecitabine in patients with advanced solid tumors.
Topics: Adult; Aged; Antibiotics, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cohort Studies; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Indoles; Male; Middle Aged; Monocytes; Neoplasms; Phosphorylation; Protein Kinase C; Protein Kinase C beta | 2008 |
Fixed dose rate infusion of gemcitabine with oral doxifluridine and leucovorin for advanced unresectable pancreatic cancer: a phase II study.
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Deoxycytidine; Disease-Free Survival; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Humans; Infusions, Intravenous; Leucovorin; Male; Middle Aged; Pancreatic Neoplasms; Remission Induction; Survival Analysis; Treatment Outcome | 2008 |
Multi-center phase II study for combination therapy with paclitaxel/doxifluridine to treat advanced/recurrent gastric cancer showing resistance to S-1 (OGSG 0302).
Topics: Adenocarcinoma; Aged; Anemia; Anorexia; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Drug Combinations; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Neutropenia; Oxonic Acid; Paclitaxel; Peritoneal Neoplasms; Stomach Neoplasms; Survival Rate; Tegafur; Thrombocytopenia | 2008 |
Efficacy of doxifluridine combined with weekly paclitaxel therapy in the treatment of advanced or recurrent breast cancer: results of the JMTO BC01 phase II trial.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Disease-Free Survival; Female; Floxuridine; Humans; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Survival Analysis | 2008 |
[A randomized controlled trial of postoperative adjuvant chemotherapy for colorectal cancer-optimal duration of the treatment].
Topics: Adult; Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Colorectal Neoplasms; Floxuridine; Follow-Up Studies; Humans; Middle Aged; Prospective Studies; Survival Rate; Time Factors | 2009 |
Phase I study of irinotecan and doxifluridine for metastatic colorectal cancer focusing on the UGT1A1*28 polymorphism.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Polymorphism, Genetic | 2010 |
A phase II study of doxifluridine and docetaxel combination chemotherapy for advanced or recurrent gastric cancer.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Docetaxel; Female; Floxuridine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasm Recurrence, Local; Stomach Neoplasms; Survival Rate; Taxoids; Treatment Outcome | 2009 |
Plasma disposition of capecitabine and its metabolites 5'DFCR and 5'DFUR in a standard and dose-intensified monotherapy regimen.
Topics: Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Cross-Over Studies; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2011 |
Hepatic arterial infusion with oxaliplatin, irinotecan and doxifluridine for unresectable liver metastases of colorectal cancer.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemoembolization, Therapeutic; Colorectal Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Iodized Oil; Irinotecan; Liver Neoplasms; Male; Middle Aged; Organoplatinum Compounds; Oxaliplatin | 2010 |
A phase II study of weekly paclitaxel and doxifluridine combination chemotherapy for advanced/recurrent gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cell Differentiation; Female; Floxuridine; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Paclitaxel; Stomach Neoplasms; Survival Rate; Treatment Outcome | 2011 |
Weekly paclitaxel in combination with doxifluridine for peritoneally disseminated gastric cancer with malignant ascites.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Ascites; Dose-Response Relationship, Drug; Female; Floxuridine; Humans; Male; Middle Aged; Paclitaxel; Peritoneal Neoplasms; Remission Induction; Stomach Neoplasms; Time Factors; Treatment Outcome | 2011 |
Factors predicting the response to oral fluoropyrimidine drugs: a phase II trial on the individualization of postoperative adjuvant chemotherapy using oral fluorinated pyrimidines in stage III colorectal cancer treated by curative resection (ACT-01 Study)
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Confidence Intervals; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Floxuridine; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Neoplasm Staging; Orotate Phosphoribosyltransferase; Proportional Hazards Models; RNA, Messenger; Tegafur; Thymidine Phosphorylase; Thymidylate Synthase | 2013 |
Adjuvant chemotherapy for gastric cancer: a randomised phase 3 trial of mitomycin-C plus either short-term doxifluridine or long-term doxifluridine plus cisplatin after curative D2 gastrectomy (AMC0201).
Topics: Adolescent; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Female; Floxuridine; Follow-Up Studies; Gastrectomy; Humans; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Neoplasm Staging; Prognosis; Prospective Studies; Stomach Neoplasms; Survival Rate; Time Factors; Young Adult | 2013 |
Combination phase II study of weekly paclitaxel and 5'-DFUR for unresectable or recurrent gastric cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Stomach Neoplasms; Survival Rate | 2013 |
UDP-glucuronosyltransferase (UGT) 1A1*28 polymorphism-directed phase II study of irinotecan with 5'-deoxy-5-fluorouridine (5'-DFUR) for metastatic colorectal cancer.
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Glucuronosyltransferase; Humans; Irinotecan; Male; Middle Aged; Neoplasm Metastasis; Polymorphism, Genetic; Survival Analysis; Time Factors; Treatment Outcome | 2013 |
Higher capecitabine AUC in elderly patients with advanced colorectal cancer (SWOGS0030).
Topics: Age Factors; Aged; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Glomerular Filtration Rate; Humans; Male; Metabolic Clearance Rate; Middle Aged; Sex Factors | 2013 |
Enhanced efficacy of postoperative adjuvant chemotherapy in advanced gastric cancer: results from a phase 3 randomized trial (AMC0101).
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Female; Floxuridine; Humans; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Stomach Neoplasms | 2014 |
Simultaneous determination of capecitabine and its three nucleoside metabolites in human plasma by high performance liquid chromatography-tandem mass spectrometry.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Male; Neoplasms; Tandem Mass Spectrometry; Therapeutic Equivalency | 2015 |
Pharmacokinetics and pharmacogenetics of capecitabine and its metabolites following replicate administration of two 500 mg tablet formulations.
Topics: Activation, Metabolic; Administration, Oral; Adult; Aged; Alleles; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carboxylesterase; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Genotype; Humans; Liver; Male; Methylenetetrahydrofolate Reductase (NADPH2); Middle Aged; Neoplasm Proteins; Polymorphism, Single Nucleotide; Prodrugs; Tablets; Therapeutic Equivalency; Thymidine Phosphorylase; Thymidylate Synthase | 2015 |
Randomized Controlled Trial of Adjuvant Chemotherapy with Fluoropyrimidines
Topics: Adult; Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Analysis; Tegafur; Uracil | 2017 |
520 other study(ies) available for doxifluridine and floxuridine
| Article | Year |
|---|---|
Fluorinated pyrimidine nucleosides. 3. Synthesis and antitumor activity of a series of 5'-deoxy-5-fluoropyrimidine nucleosides.
Topics: Animals; Antineoplastic Agents; Flucytosine; Fluorouracil; Mice; Pyrimidine Nucleosides; Sarcoma 180; Structure-Activity Relationship | 1979 |
Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.
Topics: Computational Biology; Drug Design; Humans; Isoenzymes; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Quantitative Structure-Activity Relationship | 2008 |
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship | 2010 |
[A case of multiple pulmonary metastases from duodenal cancer showing partial response using 5'-DFUR and a small dose of MMC].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Duodenal Neoplasms; Female; Floxuridine; Humans; Lung Neoplasms; Mitomycin; Pancreaticoduodenectomy | 1992 |
Some factors affecting sister-chromatid differentiation (SCD) and sister-chromatid exchange (SCE) in Hordeum vulgare.
Topics: Analysis of Variance; Ascorbic Acid; Bromodeoxyuridine; Cell Division; Doxorubicin; Floxuridine; Free Radicals; Hordeum; Maleic Hydrazide; Mitomycin; Mutagenicity Tests; Sister Chromatid Exchange; Sulfhydryl Compounds; Temperature | 1992 |
[A case of advanced breast cancer responding to low-dose 5'-DFUR].
Topics: Aged; Antineoplastic Agents; Bone Neoplasms; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis | 1992 |
[A case report; 5'-DFUR reduced gastric cancer with multiple liver metastasis].
Topics: Adenocarcinoma; Antineoplastic Agents; Floxuridine; Humans; Liver Neoplasms; Male; Middle Aged; Stomach Neoplasms; Tomography, X-Ray Computed | 1992 |
[A case of gastric cancer with recurrent bone metastases successfully treated with induced hypertension chemotherapy using cisplatin].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Blood Pressure; Bone and Bones; Bone Neoplasms; Chemotherapy, Adjuvant; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Gastrectomy; Humans; Radionuclide Imaging; Stomach Neoplasms; Tegafur | 1992 |
A comparative study of the antitumor activities of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine (Ro09-1390) on human digestive organ cancer xenograft lines transplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Digestive System Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Neoplasm Transplantation; Prodrugs; Transplantation, Heterologous | 1992 |
[Two cases of pulmonary metastasis of colorectal cancer successfully treated with oral 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Humans; Lung; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Remission Induction; Sigmoid Neoplasms; Tomography, X-Ray Computed | 1992 |
Reversal of resistance to doxifluridine and fluorouracil in metastatic colorectal cancer: the role of high-dose folinic acid.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Male; Middle Aged; Neoplasm Metastasis | 1992 |
[Successful treatment of disseminated breast cancer with combination therapy of 5'-deoxy-5'-fluorouridine (5'-DFUR), medroxyprogesterone acetate (MPA) and cyclophosphamide (CPA)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Papillary; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Medroxyprogesterone; Medroxyprogesterone Acetate; Menopause; Middle Aged; Pleural Neoplasms; Soft Tissue Neoplasms | 1992 |
Effect of folinic acid on fluorouracil activity and expression of thymidylate synthase.
Topics: Animals; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Leucovorin; Mice; Mice, Inbred BALB C; Thymidine; Thymidylate Synthase; Tumor Cells, Cultured; Uridine Monophosphate | 1992 |
[A case of recurrent esophageal cancer maintaining complete long-term response after 5'-DFUR and ftorafur administrations].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Esophageal Neoplasms; Floxuridine; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Tegafur | 1992 |
Interactions of interferon-alpha 2a with 5'-deoxy-5-fluorouridine in colorectal cancer cells in vitro.
Topics: Antineoplastic Agents; Cell Division; Colorectal Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Thymidine Phosphorylase; Tumor Cells, Cultured | 1992 |
[Phase II study of 5'-DFUR in uterine cervical cancer and ovarian cancer].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Administration, Oral; Adult; Aged; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Middle Aged; Ovarian Neoplasms; Uterine Cervical Neoplasms | 1991 |
Anticachectic activity of 5'-deoxy-5-fluorouridine in a murine tumor cachexia model, colon 26 adenocarcinoma.
Topics: Acute-Phase Proteins; Adenocarcinoma; Animals; Antineoplastic Agents; Biomarkers, Tumor; Cachexia; Colonic Neoplasms; Floxuridine; Isomerism; Male; Mice; Mice, Inbred Strains | 1990 |
Evaluation of antiproliferative agents using a cell-culture model.
Topics: Animals; Bleomycin; Cell Count; Cell Division; Cells, Cultured; Colorimetry; Cricetinae; Cytarabine; Drug Evaluation, Preclinical; Floxuridine; Fluorouracil; Tetrazolium Salts; Thiazoles; Time Factors; Uridine | 1990 |
[5'-deoxy-5-fluorouridine (5'-DFUR), mitomycin C (MMC), etoposide and medroxy progesterone acetate (MPA) in a previously treated patient with advanced breast cancer].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Etoposide; Female; Floxuridine; Humans; Liver Neoplasms; Lymphatic Metastasis; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Mitomycin; Mitomycins; Remission Induction | 1991 |
Activation and cytotoxicity of 5'-deoxy-5-fluorouridine in c-H-ras transformed NIH 3T3 cells.
Topics: Animals; Biotransformation; Cell Survival; Cell Transformation, Neoplastic; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Genes, ras; Mice; Mice, Nude; Structure-Activity Relationship; Transfection; Tumor Cells, Cultured | 1991 |
[5-fluorouracil concentration in gastroenterological tumor tissues, in adjacent normal tissues, and in serum after preoperative oral administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Colonic Neoplasms; Floxuridine; Fluorouracil; Gallbladder Neoplasms; Humans; Stomach Neoplasms | 1991 |
[5-Fluorouracil level and pyrimidine nucleoside phosphorylase activity in cancer patients after oral administration of doxifluridine (5'-DFUR)].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Stomach Neoplasms | 1991 |
[Antitumor activity of T-506, a novel synthetic FUDR derivative, on murine colon cancer and its hepatic metastasis].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorodeoxyuridylate; Liver Neoplasms; Mice; Mice, Inbred BALB C; Tegafur; Uracil | 1991 |
Phase II clinical trial of doxifluridine in patients with advanced ovarian cancer.
Topics: Adult; Aged; Antineoplastic Agents; Drug Evaluation; Female; Floxuridine; Humans; Kidney; Middle Aged; Ovarian Neoplasms | 1991 |
[Comparative studies on the antitumor activity of fluorinated pyrimidine derivatives against human bladder, cervical and ovarian cancer xenografts in nude mice].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Nude; Ovarian Neoplasms; Tegafur; Uracil; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms | 1991 |
Metabolic fates of 2'-deoxy-5-[18F]fluorouridine in tumor-bearing mice and human plasma.
Topics: Animals; Biotransformation; Brain Neoplasms; Floxuridine; Fluorine Radioisotopes; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Neoplasms, Experimental; Tissue Distribution | 1991 |
[Phase II study of 5'-DFUR (Furtulon) capsule for bladder cancer].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Carcinoma, Squamous Cell; Carcinoma, Transitional Cell; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Male; Middle Aged; Nausea; Urinary Bladder Neoplasms | 1991 |
[Phase II study of 5'-DFUR treatment of the bladder and prostatic cancer].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Anorexia; Antineoplastic Agents; Diarrhea; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Multicenter Studies as Topic; Nausea; Prostatic Neoplasms; Urinary Bladder Neoplasms | 1991 |
[A case of pulmonary metastasis from colon cancer responding completely to high-dose 5'-DFUR plus MMC combination chemotherapy].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Intravenous; Lung Neoplasms; Mitomycin | 1991 |
5'-Deoxy-5-fluorouridine improves cachexia by a mechanism independent of its antiproliferative action in colon 26 adenocarcinoma-bearing mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Cachexia; Cell Division; Colonic Neoplasms; Drug Resistance; Drug Screening Assays, Antitumor; Floxuridine; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neoplasm Transplantation; Time Factors; Tumor Cells, Cultured | 1991 |
[Investigation of 5-fluorouracil (5-FU) levels and pyrimidine nucleoside phosphorylase activities in the tissues from patients with uterine cervical and ovarian cancers after oral administration of 5'-DFUR].
Topics: Administration, Oral; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Ovarian Neoplasms; Ovary; Pentosyltransferases; Pyrimidine Phosphorylases; Uterine Cervical Neoplasms; Uterus | 1991 |
Comparative antitumor activity of 5-fluorouracil and its prodrugs in combination with hyperthermia in vitro.
Topics: Antineoplastic Agents; Cell Survival; Floxuridine; Fluorouracil; Hot Temperature; Humans; Infant, Newborn; Prodrugs; Tegafur; Tumor Cells, Cultured | 1991 |
Pharmacokinetic study of doxifluridine given by 5-day stepped-dose infusion.
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms | 1990 |
In vivo 19F NMR spectroscopy of the antimetabolite 5-fluorouracil and its analogues. An assessment of drug metabolism.
Topics: Animals; Antineoplastic Agents; beta-Alanine; Carcinoid Tumor; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Liver; Magnetic Resonance Spectroscopy; Neoplasms, Experimental; Rats; Rats, Inbred Strains; Tegafur | 1990 |
Comparative antitumor activity and intestinal toxicity of 5'-deoxy-5-fluorouridine and its prodrug trimethoxybenzoyl-5'-deoxy-5-fluorocytidine.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Prodrugs | 1990 |
[A study on preoperative administration of doxifluridine in carcinoma of the colon and rectum].
Topics: Adenocarcinoma; Administration, Oral; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care | 1990 |
[Doxifluridine toxicity, a fluorouracil analog with low myelosuppressive effect].
Topics: Administration, Oral; Antineoplastic Agents; Bone Marrow; Central Nervous System; Floxuridine; Heart; Humans; Infusions, Intravenous; Leukopenia; Thrombocytopenia | 1990 |
[A progressive gastric cancer in which preoperative oral chemotherapy resulted in a histopathological "Grade 2" rating].
Topics: Adenocarcinoma; Antineoplastic Agents; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Gastrectomy; Gastroscopy; Humans; Male; Middle Aged; Remission Induction; Stomach Neoplasms | 1990 |
[Chemotherapy with fluoropyrimidines for MOPC-104E plasmacytoma transplanted in mice with CCl4 induced chronic liver dysfunction].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carbon Tetrachloride Poisoning; Chemical and Drug Induced Liver Injury; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Plasmacytoma; Tegafur; Uracil | 1990 |
[Combination therapy with 5'DFUR and MPA as a second line treatment for advanced/recurrent breast cancer].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Floxuridine; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Recurrence, Local | 1990 |
Optimal treatment regimens for 5'-deoxy-5-fluorouridine, with or without (E)-5-(2-bromovinyl)-2'-deoxyuridine, against various tumors in mice.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Antiviral Agents; Bromodeoxyuridine; Colonic Neoplasms; Drug Therapy, Combination; Floxuridine; Fluorouracil; Liver Neoplasms; Lung Neoplasms; Mice; Mice, Inbred BALB C; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases | 1990 |
[The study of 5-FU levels and pyrimidine nucleoside phosphorylase (PyNPase) activity in human breast cancer tissue after administration of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1990 |
A phase I study of doxifluridine as a five-day stepped-dose continuous infusion.
Topics: Adult; Aged; Antineoplastic Agents; Cohort Studies; Dose-Response Relationship, Drug; Drug Evaluation; Female; Floxuridine; Humans; Infusions, Intravenous; Male; Middle Aged; Neoplasms; Remission Induction | 1990 |
Comparative studies on the antitumor and immunosuppressive effects of the new fluorouracil derivative N4-trimethoxybenzoyl-5'-deoxy-5-fluorocytidine and its parent drug 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Deoxycytidine; Floxuridine; Immunosuppressive Agents; Male; Mice; Mice, Inbred Strains; Prodrugs; Tumor Cells, Cultured | 1990 |
[Preoperative chemotherapy and anti-cancer effect of gastric carcinoma].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Evaluation; Floxuridine; Fluorouracil; Gastrectomy; Humans; Middle Aged; Neoplasm Staging; Preoperative Care; Stomach Neoplasms | 1990 |
[Study of tissue drug concentration of fluorinated pyrimidine anticancer drugs--comparison of 5'DFUR and UFT].
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colon; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Lymph Nodes; Tegafur; Uracil | 1990 |
[Experimental study relating to the anti-cancer effect of doxifluridine].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Squamous Cell; Drug Screening Assays, Antitumor; Female; Floxuridine; Methylcholanthrene; Mice; Mice, Inbred Strains; Skin Neoplasms | 1990 |
[A resected case of gastric carcinoma with complete remission of Virchow's node metastasis by 5'-DFUR administration].
Topics: Adenocarcinoma; Antineoplastic Agents; Combined Modality Therapy; Female; Floxuridine; Gastrectomy; Humans; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neck; Remission Induction; Stomach Neoplasms | 1990 |
[A markedly effective combination therapy of 5'-DFUR and MMC in advanced gastric cancer--a case report].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Humans; Mitomycin; Mitomycins; Remission Induction; Stomach Neoplasms | 1990 |
Kinetic analysis of 5-fluorouracil action against various cancer cells.
Topics: Animals; Antineoplastic Agents; Cell Cycle; Colonic Neoplasms; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Leukemia P388; Mice; RNA, Ribosomal; S Phase; Time Factors; Uridine | 1990 |
[A study on pre-operative administration of 5'-DFUR in carcinomas of the gastric, breast, thyroid and colon].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases; Stomach Neoplasms; Thyroid Neoplasms; Tissue Distribution | 1990 |
[Two cases of obstructive jaundice due to extrahepatic carcinoma of the bile duct with marked response to daily oral administration of etoposide].
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Cholestasis, Extrahepatic; Common Bile Duct Neoplasms; Etoposide; Female; Floxuridine; Humans; Male; Middle Aged; Picibanil; Remission Induction; Tegafur; Uracil | 1990 |
Glycosidic bond cleavage of 5-fluoro-2'-deoxyuridine and 5-fluorouridine by amino acyl-tRNA synthetases.
Topics: Animals; Chromatography, Thin Layer; Cytoplasm; Floxuridine; Glycoside Hydrolases; Glycosides; Hydrolysis; Liver; Lysine-tRNA Ligase; Rats; Rats, Inbred Strains; Uridine | 1990 |
[5'-Deoxy-5-fluorouridine and 5-fluorouracil concentrations and thymidine phosphorylase activity in brain tumors following intravenous administration of 5'-deoxy-5-fluorouridine].
Topics: Adult; Aged; Astrocytoma; Brain Neoplasms; Cerebral Ventricle Neoplasms; Child; Choroid Plexus; Ependymoma; Female; Floxuridine; Fluorouracil; Glioma; Humans; Infant; Male; Middle Aged; Papilloma; Pentosyltransferases; Thymidine Phosphorylase | 1985 |
[Pharmacokinetics of anticancer drugs in hamsters with tongue carcinoma].
Topics: Animals; Bleomycin; Carcinoma; Cricetinae; Floxuridine; Kinetics; Male; Mesocricetus; Peplomycin; Tissue Distribution; Tongue Neoplasms | 1986 |
Modulation of cytotoxicity and metabolism of 5-fluorouracil in two intestine cell lines.
Topics: Cell Cycle; Cell Line; DNA; Drug Synergism; Floxuridine; Fluorouracil; Humans; Hypoxanthine; Hypoxanthines; In Vitro Techniques; Inosine; Organophosphorus Compounds; Pentosyltransferases; Pyrimidine Phosphorylases; Ribosemonophosphates; RNA; Thymidine; Thymidylate Synthase | 1986 |
Correlation between ribosomal RNA production and RNA-directed fluoropyrimidine cytotoxicity.
Topics: Animals; Cell Nucleus; Cell Survival; Cytoplasm; DNA; Floxuridine; Fluorouracil; Mice; RNA; RNA, Messenger; RNA, Ribosomal; Sarcoma 180; Uridine | 1987 |
[Problems in the development of analogs of anticancer drugs].
Topics: Antineoplastic Agents; Bleomycin; Cisplatin; Doxorubicin; Floxuridine; Organoplatinum Compounds; Vincristine | 1988 |
[The serum and tissue concentration of FT-207, 5'-DFUR and 5-FU in patients with breast cancer by preoperative administration of UFT and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Floxuridine; Fluorouracil; Humans; Lymph Nodes; Preoperative Care; Tegafur; Tissue Distribution; Uracil | 1989 |
Enhanced therapeutic efficacy of 5'deoxy-5-fluorouridine in 5-fluorouracil resistant head and neck tumours in relation to 5-fluorouracil metabolising enzymes.
Topics: Animals; Antineoplastic Agents; Carcinoma; Colonic Neoplasms; Drug Resistance; Female; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Isomerism; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Pyrimidine Phosphorylases | 1989 |
Enhanced antitumor effect of 5'-deoxy-5-fluorouridine by oral administration with L-cysteine.
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Chromatography, High Pressure Liquid; Colonic Neoplasms; Cysteine; Drug Synergism; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Lung Neoplasms; Male; Mice | 1989 |
[Two cases of gastrointestinal cancers with major responses to sequential methotrexate 5-FU plus 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Leucovorin; Liver Neoplasms; Lymphatic Metastasis; Male; Methotrexate; Middle Aged; Neoplasm Recurrence, Local; Remission Induction; Stomach Neoplasms | 1989 |
Phase I study of oral doxifluridine using two schedules.
Topics: Adult; Aged; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Drug Tolerance; Female; Floxuridine; Humans; Isomerism; Male; Middle Aged; Neoplasms | 1989 |
Enhancing effect of bromovinyldeoxyuridine on antitumor activity of 5'-deoxy-5-fluorouridine against adenocarcinoma 755 in mice. Correlation with pharmacokinetics of plasma 5-fluorouracil levels.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bromodeoxyuridine; Chromatography, High Pressure Liquid; Drug Synergism; Floxuridine; Fluorouracil; Half-Life; Male; Mice; Neoplasm Transplantation; Spectrophotometry, Ultraviolet | 1989 |
Biologic activity of 5'-deoxy-5-fluorouridine by rectal administration.
Topics: Administration, Rectal; Animals; Antineoplastic Agents; Female; Floxuridine; Leukocyte Count; Neoplasms, Experimental; Platelet Count; Rats | 1989 |
Absorption of 5'-deoxy-5-fluorouridine from colon.
Topics: Animals; Antineoplastic Agents; Biological Availability; Colon; Feces; Female; Floxuridine; Intestinal Absorption; Rats; Tissue Distribution | 1989 |
[A study of combined chemotherapy with MMC, ADM, CDDP, VP-16 and 5'DFUR (MAC-VD) in advanced cancers of digestive organs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Colonic Neoplasms; Doxorubicin; Drug Administration Schedule; Etoposide; Female; Floxuridine; Gallbladder Neoplasms; Humans; Infusions, Intravenous; Male; Middle Aged; Mitomycin; Mitomycins; Splenic Neoplasms; Stomach Neoplasms | 1989 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with radiation therapy in mice bearing colon 26 adenocarcinoma.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Bone Marrow; Colonic Neoplasms; Combined Modality Therapy; Female; Floxuridine; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Spleen; Thymus Gland; Weight Gain | 1989 |
[A case of multiple pulmonary metastases from rectal cancer which responded completely to combination chemotherapy using 5'-DFUR and MMC].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Tolerance; Floxuridine; Humans; Lung Neoplasms; Male; Mitomycin; Mitomycins; Rectal Neoplasms; Remission Induction | 1989 |
Phase I-II trial of doxifluridine (5'DFUR) administered as long-term continuous infusion using a portable infusion pump for advanced colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine; Humans; Infusion Pumps; Isomerism; Male; Middle Aged; Rectal Neoplasms; Time Factors | 1989 |
Fluoropyrimidine metabolism in human head and neck cancer xenografts and murine colon tumors.
Topics: Animals; Colonic Neoplasms; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Head and Neck Neoplasms; Humans; Mice; Neoplasm Transplantation; Orotate Phosphoribosyltransferase; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured | 1989 |
[Effect of combination chemotherapy of 5'-DFUR, cyclophosphamide and tamoxifen in a case of advanced breast cancer].
Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis; Tamoxifen | 1989 |
[Furtulon (doxifluridine) in the treatment of non-small cell bronchial carcinoma].
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Carcinoma, Squamous Cell; Drug Evaluation; Female; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged | 1987 |
[Anticancer treatment with a combination of antimetabolites of polyamine and pyrimidine].
Topics: Animals; DNA Replication; Drug Therapy, Combination; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Nude; Mitoguazone; Ornithine; Polyamines; Spermine; Stomach Neoplasms | 1985 |
[Phase I study of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Leukocyte Count; Lung Neoplasms; Male; Middle Aged; Nausea; Neoplasms | 1985 |
[Phase II study of 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with malignant cancer--a multi-institutional cooperative study].
Topics: Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Leukopenia; Male; Nausea; Neoplasms; Stomach Neoplasms | 1985 |
[A comparative study of 5'-DFUR and tegafur in recurrent breast cancer].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Capsules; Diarrhea; Drug Administration Schedule; Female; Floxuridine; Humans; Middle Aged; Nausea; Neoplasm Recurrence, Local; Soft Tissue Neoplasms; Tegafur | 1985 |
Pharmacology of 5'-deoxy-5-fluorouridine in patients with resistant ovarian cancer.
Topics: Adult; Aged; Antineoplastic Agents; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Middle Aged; Ovarian Neoplasms | 1985 |
Analysis of 5'-deoxy-5-fluorouridine and 5-fluorouracil in human plasma and urine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Humans; Hydrogen-Ion Concentration; Kinetics; Spectrophotometry, Ultraviolet | 1985 |
[Phase II study of 5'-DFUR in gastrointestinal and breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Leukopenia; Lymphatic Metastasis; Male; Melanoma; Middle Aged; Nausea; Rectal Neoplasms; Stomach Neoplasms | 1985 |
[Phase II study of 5'-DFUR (5'-deoxy-5-fluorouridine) by the Cooperative Study Group].
Topics: Administration, Oral; Adult; Aged; Anorexia; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Diarrhea; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Head and Neck Neoplasms; Humans; Male; Middle Aged; Nausea; Neoplasms; Rectal Neoplasms; Stomach Neoplasms | 1985 |
[A case of remission of metastatic gastric cancer lesions in the chest and abdominal wall by 5'-DFUR administration].
Topics: Abdominal Muscles; Adenocarcinoma; Administration, Oral; Antineoplastic Agents; Female; Floxuridine; Gastrectomy; Humans; Lymphatic Metastasis; Middle Aged; Necrosis; Peritoneal Neoplasms; Skin Neoplasms; Stomach Neoplasms; Thorax | 1985 |
Phase II study of 5'-deoxy-5-fluorouridine (doxifluridine) in advanced malignant melanoma.
Topics: Drug Evaluation; Floxuridine; Humans; Melanoma | 1986 |
The therapeutic effects of orally administered 5'-deoxy-5-fluorouridine, 1-(2-tetrahydrofuryl)-5-fluorouracil and 5-fluorouracil on experimental murine tumors.
Topics: Animals; Antineoplastic Agents; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Neoplasms, Experimental; Tegafur | 1985 |
Evidence for the importance of 5'-deoxy-5-fluorouridine catabolism in humans from 19F nuclear magnetic resonance spectrometry.
Topics: Aged; Antineoplastic Agents; beta-Alanine; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Urea | 1986 |
Precursor-dependent differences in the incorporation of fluorouracil in RNA.
Topics: Animals; Cell Survival; Cells, Cultured; Floxuridine; Fluorouracil; Mice; RNA, Neoplasm; Sarcoma, Experimental; Thymidine; Uridine | 1986 |
Combined therapy of polyamine antimetabolites and antitumor drugs for human gastric cancer xenotransplanted into nude mice.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Carcinoma; Eflornithine; Floxuridine; Fluorouracil; Mice; Mice, Inbred BALB C; Mice, Nude; Mitoguazone; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Ornithine; Stomach Neoplasms | 1986 |
Phase II clinical evaluation of doxifluridine.
Topics: Adult; Aged; Alopecia; Antineoplastic Agents; Breast Neoplasms; Central Nervous System Diseases; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine; Heart Diseases; Hematologic Diseases; Humans; Infusions, Parenteral; Kidney Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Nausea; Neoplasms; Rectal Neoplasms | 1986 |
Partial purification of a thymidine phosphorylase from human gastric cancer.
Topics: Floxuridine; Humans; In Vitro Techniques; Pentosyltransferases; Stomach Neoplasms; Thymidine; Thymidine Phosphorylase; Uridine | 1986 |
Noninvasive fluorine-19 NMR study of fluoropyrimidine metabolism in cell cultures of human pancreatic and colon adenocarcinoma.
Topics: Adenocarcinoma; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorine; Fluorouracil; Humans; Macromolecular Substances; Magnetic Resonance Spectroscopy; Pancreatic Neoplasms; Spectrum Analysis | 1986 |
[Clinical trial of 5'-deoxy-5-fluorouridine in malignant tumors under cooperative study (phase II study)].
Topics: Aged; Aged, 80 and over; Breast Neoplasms; Colonic Neoplasms; Drug Evaluation; Female; Floxuridine; Humans; Lung Neoplasms; Male; Rectal Neoplasms; Stomach Neoplasms | 1986 |
Toxicity and antitumor effect of 5-fluorouracil and its rescue by uridine.
Topics: Animals; Body Temperature Regulation; Carcinoma; Colonic Neoplasms; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Hematopoiesis; Leukocyte Count; Mice; Uridine | 1986 |
[Combination chemotherapy of human gastrointestinal and breast cancer xenografts in nude mice with 5'-deoxy-5-fluorouridine and mitomycin C].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Colonic Neoplasms; Female; Floxuridine; Humans; Male; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms | 1986 |
[Cancer chemotherapy of unresectable primary gastric cancer].
Topics: Aged; Aged, 80 and over; Antineoplastic Agents; Floxuridine; Humans; Male; Stomach Neoplasms | 1986 |
Passage of 5'-dFUrd and its metabolites 5-FU and 5-FUH2 to CSF in a clinical phase 1 study.
Topics: Adult; Aged; Drug Evaluation; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Male; Middle Aged | 1986 |
Role of administration route in the therapeutic efficacy of doxifluridine.
Topics: Administration, Oral; Animals; Biological Availability; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Infusions, Intravenous; Injections, Intravenous; Kinetics; Neoplasm Transplantation; Rats; Rats, Inbred F344 | 1987 |
[Evaluation by multiple regression analysis of factors influencing the chemosensitivity of human tumors xenografted into nude mice].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Colony-Forming Units Assay; Doxorubicin; Floxuridine; Humans; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Nimustine; Nitrosourea Compounds; Regression Analysis; Tegafur; Tumor Stem Cell Assay; Uracil | 1987 |
Enzymatic cleavage of various fluorinated pyrimidine nucleosides to 5-fluorouracil and their antiproliferative activities in human and murine tumor cells.
Topics: Animals; Cell Division; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Substrate Specificity; Thymidine Phosphorylase; Uridine Phosphorylase | 1986 |
[Combination chemotherapy with 3 or 4 drugs on human breast and gastrointestinal cancer xenografts in nude mice (II)].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Fluorouracil; Humans; Methotrexate; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Stomach Neoplasms; Tegafur; Vindesine | 1987 |
[Effects of alternating chemotherapy with 2 non-cross-resistant drug combinations on human alimentary and breast cancer xenografts in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cisplatin; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Mice; Mice, Nude; Mitomycin; Mitomycins; Neoplasm Transplantation; Pancreatic Neoplasms; Vindesine | 1987 |
Comparative antitumor activity of ruthenium derivatives with 5'-deoxy-5-fluorouridine in chemically induced colorectal tumors in SD rats.
Topics: Adenocarcinoma; Animals; Colonic Neoplasms; Dimethylnitrosamine; Floxuridine; Imidazoles; Male; Organometallic Compounds; Rats; Rats, Inbred Strains; Rectal Neoplasms; Ruthenium | 1987 |
[5'-DFUR (doxifluridine)].
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Evaluation; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Liver Neoplasms, Experimental; Mice; Sarcoma, Experimental | 1987 |
Excretion of doxifluridine catabolites in human bile assessed by 19F NMR spectrometry.
Topics: Adenocarcinoma; Adult; Antineoplastic Agents; Bile; Colonic Neoplasms; Floxuridine; Humans; Magnetic Resonance Spectroscopy; Male | 1987 |
Painful palmar and plantar erythema associated with hepatic artery infusion of 5-fluoro-2'deoxyuridine.
Topics: Erythema; Female; Floxuridine; Foot Dermatoses; Hand Dermatoses; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Middle Aged | 1987 |
Reduced hippocampal field potentials during administration of fluoropyrimidines in vitro.
Topics: Action Potentials; Animals; Evoked Potentials; Floxuridine; Fluorouracil; Hippocampus; In Vitro Techniques; Nerve Fibers; Rats; Rats, Inbred Strains; Synapses | 1987 |
[Conversion of 5'-deoxy-5-fluorouridine to 5-FU by pyrimidine nucleoside phosphorylases in normal and tumor tissues from rodents bearing tumors and cancer patients].
Topics: Animals; Antineoplastic Agents; Carcinoma 256, Walker; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Leukemia P388; Mice; Neoplasms; Neoplasms, Experimental; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Sarcoma 180 | 1987 |
[A new anticancer drug, 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Floxuridine; Humans; Male; Middle Aged; Neoplasms | 1987 |
Human urinary excretion of doxifluridine and metabolites during a 5-day chemotherapeutic schedule using fluorine-19 nuclear magnetic resonance spectrometry.
Topics: Adult; Antineoplastic Agents; Floxuridine; Humans; Magnetic Resonance Spectroscopy; Male; Time Factors | 1987 |
Enhanced antitumor activity of 5'-deoxy-5-fluorouridine against Lewis lung carcinoma in aged hybrid (C57BL/6 x DBA/2) F1 mice.
Topics: Age Factors; Animals; Antineoplastic Agents; Floxuridine; Hybridization, Genetic; Lethal Dose 50; Lung Neoplasms; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Neoplasms, Experimental; Prodrugs; Uridine Phosphorylase | 1987 |
[Antitumor effects of 5'-deoxy-5-fluorouridine (5'-DFUR) against various murine tumors in combination with recombinant interferon alpha or cytostatics].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Interferon Type I; Male; Mice; Mice, Inbred Strains; Neoplasms, Experimental; Recombinant Proteins | 1987 |
[Antitumor activity and toxicity to the immune system and intestine, of the fluorinated pyrimidines FUra, 5'-DFUR, tegafur and UFT].
Topics: Animals; Antibody Formation; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Bone Marrow; Female; Floxuridine; Intestines; Leukopenia; Lung Neoplasms; Male; Mice; Mice, Inbred C3H; Mice, Inbred Strains; Spleen; Tegafur; Thymus Gland; Uracil | 1988 |
[Comparative studies on the antitumor activity of the fluorinated pyrimidines 5'-DFUR, tegafur, UFT and FUra on various murine tumors].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Floxuridine; Fluorouracil; Leukemia P388; Liver Neoplasms, Experimental; Lung Neoplasms; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Inbred Strains; Neoplasms, Experimental; Sarcoma 180; Tegafur; Uracil | 1988 |
A phase II study of doxifluridine in patients with advanced breast cancer.
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Drug Evaluation; Female; Floxuridine; Humans; Middle Aged | 1988 |
Comparison of the pyrimidine nucleoside phosphorylase activity in human tumors and normal tissues.
Topics: Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Spectrophotometry; Stomach Neoplasms | 1988 |
Effect of uridine coadministration on 5'-deoxy-5-fluorouridine disposition in rats.
Topics: Administration, Oral; Animals; Biological Availability; Biotransformation; Floxuridine; Injections, Intravenous; Intestinal Absorption; Metabolic Clearance Rate; Rats; Rats, Inbred F344; Uridine | 1988 |
Determination of 5-fluorouracil in plasma and liver after oral administration of 5'-deoxy-5-fluorouridine using gas chromatography-mass spectrometry.
Topics: Administration, Oral; Adult; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Liver; Middle Aged | 1988 |
[Clinical trial of 5'-DFUR in patients with recurrent breast cancer].
Topics: Administration, Oral; Adult; Aged; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local | 1988 |
Inhibition of thymidylate synthase after administration of doxifluridine in a transplantable colon carcinoma in the rat.
Topics: Animals; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Male; Neoplasm Transplantation; Rats; Rats, Inbred Strains; Thymidylate Synthase | 1988 |
Experimental and clinical studies on the anticancer agent, doxifluridine (5'-DFUR), Satellite symposium to the 25th annual meeting of the Japan Society for Cancer Therapy. Sapporo, Japan, 7 October 1987. Abstracts.
Topics: Animals; Antineoplastic Agents; Floxuridine; Humans | 1988 |
The in vitro stability of doxifluridine in whole blood and plasma.
Topics: Drug Stability; Floxuridine; Fluorouracil; Half-Life; Humans | 1988 |
The antiproliferative effects of fluoropyrimidine derivatives against human tumor xenografts in a subrenal capsule assay.
Topics: Animals; Antineoplastic Agents; Body Weight; Cell Division; Colorectal Neoplasms; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Nude; Stomach Neoplasms; Subrenal Capsule Assay; Tegafur; Transplantation, Heterologous | 1988 |
Inhibition of intestinal pyrimidine nucleoside phosphorylases.
Topics: Animals; Antineoplastic Agents; Cells, Cultured; Female; Floxuridine; Intestines; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Inbred Strains | 1987 |
Neurological manifestations in a phase 2 study of 13 patients treated with doxyfluridine.
Topics: Adult; Age Factors; Aged; Antineoplastic Agents; Body Weight; Brain Diseases; Cerebellar Diseases; Colonic Neoplasms; Female; Floxuridine; Humans; Middle Aged; Nervous System Diseases; Peripheral Nervous System Diseases; Rectal Neoplasms | 1985 |
[Clinical phase II study of 5'-DFUR for cancer of the digestive organs by a cooperative study group].
Topics: Adenocarcinoma; Adenocarcinoma, Mucinous; Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Male; Middle Aged; Stomach Neoplasms | 1985 |
5-Fluoro-5'-deoxyuridine is an inhibitor of uridylate nucleotidase in L1210 leukaemia.
Topics: 5'-Nucleotidase; Animals; Antimetabolites, Antineoplastic; Biotransformation; Cell Cycle; DNA, Neoplasm; Floxuridine; Fluorouracil; Leukemia L1210; Mice; Nucleotidases; Pentosyltransferases; Pyrimidine Phosphorylases; RNA, Neoplasm; Thymidylate Synthase | 1986 |
Potentiation of the chemotherapeutic action of 5'-deoxy-5-fluorouridine in combination with guanosine and related compounds.
Topics: Animals; Drug Synergism; Floxuridine; Guanine Nucleotides; Guanosine; Guanosine Monophosphate; Inosine; Leukemia P388; Leukemia, Experimental; Male; Mast-Cell Sarcoma; Mice; Mice, Inbred Strains; Uric Acid | 1987 |
[A case of gastric cancer in which long-term administration of 5'-deoxy-5-fluorouridine (5'-DFUR) proved effective].
Topics: Adenocarcinoma, Mucinous; Antineoplastic Agents; Female; Floxuridine; Humans; Long-Term Care; Middle Aged; Stomach Neoplasms | 1987 |
Elevation of plasma levels of fluorinated pyrimidines by guanosine 5'-monophosphate.
Topics: Animals; Deoxycytidine; Drug Interactions; Floxuridine; Fluorouracil; Guanine Nucleotides; Guanosine Monophosphate; Guanosine Triphosphate; Inosine Monophosphate; Male; Mice | 1987 |
[Experimental results of survivals with different dose schedule of 5-FU and 5'-DFUR].
Topics: Animals; Antineoplastic Agents; Drug Administration Schedule; Floxuridine; Fluorouracil; Lung Neoplasms; Male; Mice | 1985 |
The degradation of 5'-deoxy-5-fluorouridine by pyrimidine nucleoside phosphorylase in normal and cancer tissues.
Topics: Animals; Colon; Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Humans; Hydrogen-Ion Concentration; Intestine, Small; Kinetics; Lymph Nodes; Mice; Pentosyltransferases; Pyrimidine Phosphorylases; Spectrophotometry, Ultraviolet; Tissue Distribution | 1985 |
Antitumor activity of a new fluoropyrimidine derivative, 5'-deoxy-5-fluorouridine, against murine and human experimental tumors.
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Humans; Leukemia L1210; Leukemia P388; Male; Melanoma; Mice; Mice, Nude; Neoplasm Transplantation; Neoplasms, Experimental | 1985 |
[Clinical effect of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Antineoplastic Agents; Breast Neoplasms; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Humans; Male; Stomach Neoplasms | 1985 |
[Pyrimidine nucleoside phosphorylase in brain tumors and anti-tumor effect of 5'-DFUR].
Topics: Animals; Antineoplastic Agents; Brain Neoplasms; Floxuridine; Glioma; Isomerism; Mice; Mice, Inbred C57BL; Neoplasm Transplantation; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Rats, Inbred Strains | 1984 |
Antiproliferative action of a novel fluorinated uridine analog, 5'-deoxy-5-fluorouridine, measured in vitro and in vivo on four different murine tumor lines.
Topics: Animals; Cell Line; Drug Evaluation, Preclinical; Floxuridine; Isomerism; Lung Neoplasms; Lymphoma; Melanoma; Mice; Neoplasms, Experimental; Sarcoma 180 | 1982 |
A simple and convenient assay method for phosphorolysis of 5'-deoxy-5-fluorouridine.
Topics: Animals; Bacteriological Techniques; Floxuridine; Humans; Mice; Mice, Inbred Strains; Micrococcus; Mutation; Pentosyltransferases; Sarcoma 180; Uridine Phosphorylase | 1981 |
Reversed-phase ion-pair high-performance liquid chromatographic assay of 5-fluorouracil, 5'-deoxy-5-fluorouridine, their nucleosides, mono-, di-, and triphosphate nucleotides with a mixture of quaternary ammonium ions.
Topics: Chromatography, High Pressure Liquid; Deoxyuracil Nucleotides; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Isomerism; Structure-Activity Relationship; Uracil Nucleotides; Uridine | 1982 |
Phase I clinical study with 5'-deoxy-5-fluorouridine, a new fluoropyrimidine derivative.
Topics: Adult; Aged; Agranulocytosis; Antineoplastic Agents; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Half-Life; Humans; Kinetics; Leukocyte Count; Leukopenia; Male; Middle Aged; Neoplasms; Platelet Count; Stomatitis; Thrombocytopenia | 1982 |
Modulation of 1-beta-D-arabinofuranosylcytosine metabolism and cytotoxicity in L1210 cells by fluoropyrimidine pretreatment.
Topics: Animals; Arabinofuranosylcytosine Triphosphate; Cell Line; Cell Survival; Clone Cells; Cytarabine; Deoxyribonucleotides; Deoxyuridine; Drug Interactions; Floxuridine; Fluorodeoxyuridylate; Fluorouracil; Leukemia L1210; Mice; Uridine | 1982 |
Quantitative analysis of 5-fluorouracil and 5,6-dihydrofluorouracil in plasma by gas chromatography mass spectrometry.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Fluorouracil; Gas Chromatography-Mass Spectrometry; Humans; Time Factors; Uracil | 1982 |
Evidence that 5'-deoxy-5-fluorouridine may not be activated by the same mechanism as 5-fluorouracil.
Topics: Animals; Biotransformation; Cells, Cultured; Floxuridine; Fluorouracil; Inosine; Liver Neoplasms, Experimental | 1982 |
Studies on the designing of chemotherapy for gastric cancer in man, based on the tumor tissue concentration of anticancer agents.
Topics: Antineoplastic Agents; Floxuridine; Fluorouracil; Gastric Mucosa; Humans; Stomach Neoplasms; Tegafur | 1982 |
Kinetics and metabolism of a new fluoropyrimidine, 5'-deoxy-5-fluorouridine, in humans.
Topics: Colonic Neoplasms; Drug Evaluation; Floxuridine; Humans; Isomerism; Kinetics; Neoplasm Metastasis; Pancreatic Neoplasms | 1983 |
Differential selectivity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in cultured human B lymphocytes and mouse L1210 leukemia.
Topics: Animals; Antineoplastic Agents; Ascitic Fluid; B-Lymphocytes; Biotransformation; Cell Division; Cells, Cultured; DNA; Female; Floxuridine; Fluorouracil; Humans; Leukemia L1210; Mice; Mice, Inbred DBA; Uridine Phosphorylase | 1983 |
5'-Deoxy-5-fluorouridine selective toxicity for human tumor cells compared to human bone marrow.
Topics: Antineoplastic Agents; Bone Marrow; Breast Neoplasms; Cell Survival; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Leukemia, Myeloid, Acute; Neoplasms; Osteosarcoma | 1983 |
Decreased immunosuppression associated with antitumor activity of 5-deoxy-5-fluorouridine compared to 5-fluorouracil and 5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Survival; Female; Floxuridine; Fluorouracil; Immunosuppression Therapy; Inflammation; Male; Mice; Mice, Inbred C57BL; Pyrans; Thioglycolates; Uridine | 1983 |
Activation of 5'-deoxy-5-fluorouridine by thymidine phosphorylase in human tumors.
Topics: Animals; Biotransformation; Floxuridine; Guinea Pigs; Humans; Male; Mice; Middle Aged; Neoplasms; Pentosyltransferases; Thymidine Phosphorylase | 1983 |
Cytotoxic activity of 5'-deoxy-5-fluorouridine in cultured human tumors.
Topics: Breast Neoplasms; Cell Line; Cell Survival; Colonic Neoplasms; Drug Evaluation, Preclinical; Female; Floxuridine; Humans; Lethal Dose 50; Leukemia, Myeloid, Acute; Neoplasms; Osteosarcoma; Pancreatic Neoplasms | 1983 |
[Pharmacological and pharmacodynamic aspects of cancer chemotherapy, with special reference to 5-fluorouracil and its derivatives].
Topics: Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Floxuridine; Fluorouracil; Humans; Kinetics; Neoplasms; Tegafur; Uracil | 1982 |
[Pharmacokinetics of 5'-deoxy-5-fluorouridine (5'-DFUR)].
Topics: Administration, Oral; Animals; Cricetinae; Floxuridine; Kinetics; Male; Mice; Neoplasms, Experimental; Rabbits; Sarcoma 180; Tissue Distribution | 1983 |
Mechanism of cytotoxic activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; DNA, Neoplasm; Floxuridine; Neoplasm Proteins; RNA, Neoplasm; Thymidylate Synthase | 1983 |
Simultaneous analysis of 5'-deoxy-5-fluorouridine and 5-fluorouracil in plasma by analytical isotachophoresis.
Topics: Electrophoresis; Floxuridine; Fluorouracil; Humans | 1983 |
[Activities of pyrimidine nucleoside phosphorylase in brain tumors and antitumor effect of 5'-DFUR].
Topics: Antineoplastic Agents; Astrocytoma; Brain Neoplasms; Floxuridine; Glioma; Humans; Meningeal Neoplasms; Meningioma; Oligodendroglioma; Pentosyltransferases; Pyrimidine Phosphorylases; Sarcoma | 1983 |
Detection of fluoropyrimidines and their metabolites in biological samples by fluorine-19 NMR: application to 5'-deoxy-5-fluorouridine.
Topics: Female; Floxuridine; Fluorine; Humans; Magnetic Resonance Spectroscopy | 1983 |
Phase II study of doxifluridine in advanced colorectal adenocarcinoma.
Topics: Adenocarcinoma; Adult; Aged; Antineoplastic Agents; Chemical Phenomena; Chemistry; Colonic Neoplasms; Drug Eruptions; Drug Evaluation; Female; Floxuridine; Heart; Humans; Leukopenia; Male; Middle Aged; Nausea; Rectal Neoplasms; Thrombocytopenia; Vomiting | 1983 |
Phase II study of doxifluridine in advanced squamous cell carcinoma of the head and neck.
Topics: Aged; Antineoplastic Agents; Bone Marrow Diseases; Carcinoma, Squamous Cell; Drug Administration Schedule; Drug Evaluation; Female; Floxuridine; Head and Neck Neoplasms; Humans; Male; Middle Aged | 1984 |
Tumor specific conversion of a pyrimidine antimetabolite.
Topics: Animals; Antineoplastic Agents; Cell Line; Floxuridine; Fluorouracil; Isomerism; Mice; Neoplasms, Experimental | 1984 |
31P-topical nuclear magnetic resonance (31P-TMR) studies of cardiotoxic effects of 5-fluorouracil (5-FU) and 5'-deoxy-5-fluorouridine (5'-DFUR).
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Electrocardiography; Floxuridine; Fluorouracil; Guinea Pigs; Heart; Magnetic Resonance Spectroscopy; Male; Myocardium; Phosphocreatine | 1984 |
New approach to metabolism of 5'-deoxy-5-fluorouridine in humans with fluorine-19 NMR.
Topics: Antineoplastic Agents; Female; Floxuridine; Fluorine; Humans; Kinetics; Lung Neoplasms; Magnetic Resonance Spectroscopy; Perfusion; Uterine Neoplasms | 1984 |
[Effects of 5'-deoxy-5-fluorouridine on human gastrointestinal and breast cancers xenografted to nude mice].
Topics: Adenocarcinoma; Administration, Oral; Animals; Breast Neoplasms; Carcinoma; Colonic Neoplasms; Female; Floxuridine; Humans; Male; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Transplantation; Rectal Neoplasms; Stomach Neoplasms; Tegafur | 1984 |
[5'-Deoxy-5-fluorouridine enzymatic activation from the masked compound to 5-fluorouracil in human malignant tissues].
Topics: Administration, Oral; Aged; Animals; Antineoplastic Agents; Enzyme Activation; Female; Floxuridine; Fluorouracil; Humans; Infusions, Parenteral; Liver Neoplasms; Lung Neoplasms; Male; Mice; Neoplasms; Pentosyltransferases; Pyrimidine Phosphorylases; Sarcoma, Experimental; Stomach Neoplasms; Uridine Phosphorylase; Uterine Neoplasms | 1984 |
[Measurement of 5'-deoxy-5-fluorouridine (5'-DFUR) by high-performance liquid chromatography and studies on pharmacokinetics of 5'-DFUR and 5-fluorouracil by oral and intravenous administration].
Topics: Administration, Oral; Aged; Chromatography, High Pressure Liquid; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Injections, Intravenous; Kinetics; Male; Middle Aged; Stomach Neoplasms | 1984 |
[Development of fluoropyrimidine derivatives].
Topics: Animals; DNA Replication; Floxuridine; Fluorouracil; Mice; Phosphorylation; Pyrimidine Nucleotides; Rats; Sarcoma, Experimental; Tegafur; Uracil | 1984 |
Prognostic factors and in vitro cytotoxic sensitivity in colorectal cancer.
Topics: Antineoplastic Agents; Cell Division; Cell Survival; Cells, Cultured; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Neoplasm Staging; Prognosis; Rectal Neoplasms; Thymidine; Tumor Stem Cell Assay | 1984 |
Phase II study of oral administration of 5'-deoxy-5-fluorouridine (5'-DFUR) for solid tumors.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Bone Marrow; Drug Evaluation; Female; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged | 1984 |
Metabolism and biological activity of 5'-deoxy-5-fluorouridine, a novel fluoropyrimidine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Cells, Cultured; Chromatography, Liquid; Floxuridine; Fluorouracil; Male; Mice; Neoplasm Transplantation; Phosphotransferases; Structure-Activity Relationship; Thymidylate Synthase | 1980 |
New implantable continuous administration and bolus dose intracarotid drug delivery system for the treatment of malignant gliomas.
Topics: Adult; Animals; Antineoplastic Agents; Brain Neoplasms; Carmustine; Carotid Arteries; Chemotherapy, Cancer, Regional Perfusion; Female; Floxuridine; Glioblastoma; Humans; Macaca mulatta; Male; Methotrexate; Middle Aged | 1982 |
Role of uridine phosphorylase for antitumor activity of 5'-deoxy-5-fluorouridine.
Topics: Animals; Biotransformation; Floxuridine; Fluorouracil; Leukemia L1210; Male; Mice; Pentosyltransferases; Sarcoma 180; Tegafur; Thymidine; Uridine; Uridine Phosphorylase | 1980 |
Tumor inhibitory effects of a new fluorouracil derivative: 5'-deoxy-5-fluorouridine.
Topics: Animals; Female; Floxuridine; Lethal Dose 50; Lung Neoplasms; Mice; Neoplasms, Experimental; Sarcoma 180; Skin Neoplasms | 1980 |
Comparative studies on the immunosuppressive effect among 5'-deoxy-5-fluorouridine, ftorafur, and 5-fluorouracil.
Topics: Animals; Antibody Formation; Erythrocytes; Female; Floxuridine; Fluorouracil; Graft Rejection; Hypersensitivity, Delayed; Immunity, Cellular; Immunosuppressive Agents; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Transplantation; Tegafur | 1980 |
Tissue distribution of 5'-deoxy-5-fluorouridine and derived 5-fluorouracil in tumor-bearing mice and rats.
Topics: Animals; Carcinoma 256, Walker; Female; Floxuridine; Fluorouracil; Male; Mice; Rats; Sarcoma 180; Tegafur; Tissue Distribution | 1980 |
Overview of new anticancer drugs of interest in Japan.
Topics: Antineoplastic Agents; Doxorubicin; Floxuridine; Humans; Imidazoles; Japan | 1980 |
Determination of a novel fluoropyrimidine, 5'-deoxy-5-fluorouridine, in plasma by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Floxuridine; Half-Life; Humans; Infusions, Parenteral; Pancreatic Neoplasms | 1981 |
[Augmentation of chemotherapeutic efficaciousness of UFT by oral l-leucovorin--growth-inhibitory activity of combination against human tumor xenograft].
Topics: Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Female; Floxuridine; Humans; Leucovorin; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Tegafur; Transplantation, Heterologous; Uracil | 1995 |
[Combination therapy of doxifluridine, pirarubicin and cisplatin for human gastric cancers implanted in nude mice].
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Cisplatin; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Stomach Neoplasms | 1995 |
[A case of advanced gastric cancer successfully treated with combination chemotherapy using THP, 5'-DFUR and CDDP, followed by surgical resection].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drug Administration Schedule; Floxuridine; Gastrectomy; Humans; Liver Neoplasms; Male; Stomach Neoplasms | 1995 |
Modulation of the antitumour activity of cisplatin alone and in combination with 5-fluoro-2'-deoxyuridine by N-phosphonacetyl-L-aspartate in murine colon carcinoma no. 26.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Aspartic Acid; Cisplatin; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Interactions; Female; Floxuridine; Mice; Mice, Inbred BALB C; Phosphonoacetic Acid; Tumor Cells, Cultured | 1995 |
[Study on pyrimidine nucleoside phosphorylase (PyNPase) activity in resected tissues of patients with gastric cancer].
Topics: Adult; Aged; CD4-CD8 Ratio; Female; Floxuridine; Gastrectomy; Humans; Lymphatic Metastasis; Lymphocyte Activation; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Stomach; Stomach Neoplasms; Tuberculin | 1995 |
[A successful 5'-DFUR and CDDP combination therapy for an advanced gastric cancer complicated with multiple liver metastases].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Floxuridine; Humans; Liver Neoplasms; Male; Stomach Neoplasms | 1995 |
Increased sensitivity to the prodrug 5'-deoxy-5-fluorouridine and modulation of 5-fluoro-2'-deoxyuridine sensitivity in MCF-7 cells transfected with thymidine phosphorylase.
Topics: Antineoplastic Agents; Biological Availability; Breast; Breast Neoplasms; Cell Communication; Cell Division; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Prodrugs; Thymidine; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1995 |
[Chemotherapy for older cancer patients].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Non-Small-Cell Lung; Carcinoma, Small Cell; Drug Administration Schedule; Etoposide; Female; Floxuridine; Granulocyte Colony-Stimulating Factor; Humans; Lung Neoplasms; Lymphoma, Non-Hodgkin; Male; Neoplasms; Neoplasms, Multiple Primary; Palliative Care; Quality of Life | 1993 |
Sensitivity of human KB cells expressing platelet-derived endothelial cell growth factor to pyrimidine antimetabolites.
Topics: Cell Division; Floxuridine; Fluorouracil; Humans; KB Cells; RNA; Tegafur; Thymidine Kinase; Thymidine Phosphorylase; Transfection | 1993 |
Inhibition of 5'-deoxy-5-fluorouridine phosphorolysis by acyclopyrimidinenucleosides in intestinal tissue homogenates.
Topics: Animals; Antineoplastic Agents; Floxuridine; Humans; In Vitro Techniques; Intestinal Mucosa; Intestines; Kinetics; Male; Mice; Mice, Inbred C57BL; Phosphorus; Pyrimidinones; Rabbits; Rats; Uridine Phosphorylase | 1995 |
Selective inhibition of spontaneous pulmonary metastasis of Lewis lung carcinoma by 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Carcinoma, Lewis Lung; Cell Division; Collagenases; Cytokines; Drug Synergism; Floxuridine; Lung Neoplasms; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured; Up-Regulation | 1995 |
[A case of pulmonary metastasis from colon cancer successfully treated with high-dose 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Agents; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged; Pneumonectomy; Remission Induction | 1995 |
Interferon alpha and 5'-deoxy-5-fluorouridine in colon cancer: effects as single agents and in combination on growth of xenograft tumours.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Interferon Type I; Male; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Recombinant Proteins; Transplantation, Heterologous | 1994 |
[Study of PyNPase activity in patients with gastric cancer--the association with preoperative IAP values].
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Female; Floxuridine; Gastrectomy; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Proteins; Neoplasm Staging; Pentosyltransferases; Prognosis; Pyrimidine Phosphorylases; Spleen; Stomach Neoplasms | 1995 |
5'-Deoxy-5-fluorouridine increases daunorubicin uptake in multidrug-resistant cells and its activity is related with P-gp 170 expression.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma; Carrier Proteins; Colonic Neoplasms; Daunorubicin; Drug Resistance; Flow Cytometry; Floxuridine; Membrane Glycoproteins; Prodrugs; Rats; Tumor Cells, Cultured | 1994 |
Simultaneous occurrence of adenomas in stomach, duodenal bulb, and colon: disappearance of gastric and duodenal adenomas during oral administration of 5'-deoxy-5-fluorouridine.
Topics: Adenoma; Aged; Antineoplastic Agents; Carcinoma, Hepatocellular; Colonic Neoplasms; Duodenal Neoplasms; Floxuridine; Humans; Isomerism; Liver Neoplasms; Male; Neoplasms, Multiple Primary; Stomach Neoplasms | 1994 |
[A case of advanced gastric cancer with liver metastasis disappeared by oral administration of 5'-deoxy-5-fluorouridine after absolute non-curative operation].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Chemotherapy, Adjuvant; Floxuridine; Gastrectomy; Humans; Liver Neoplasms; Male; Pancreatectomy; Postoperative Care; Splenectomy; Stomach Neoplasms | 1994 |
[A case of recurrent breast cancer responding to combination therapy with mitoxantrone (MIT), 5'-deoxy-5-fluorouridine (5'-DFUR) and medroxyprogesterone acetate (MPA)].
Topics: Adenocarcinoma; Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Middle Aged; Mitoxantrone; Ovariectomy | 1994 |
[A case of complete response of breast cancer with pulmonary metastases to combination therapy of 5'-DFUR and MPA].
Topics: Breast Neoplasms; Chemotherapy, Adjuvant; Drug Therapy, Combination; Female; Floxuridine; Humans; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone; Middle Aged; Remission Induction | 1994 |
[A case of cutaneous and brain metastasis of gastric carcinoma, treated effectively by chemotherapy with CDDP, MMC, etoposide and 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cisplatin; Drug Administration Schedule; Etoposide; Female; Floxuridine; Humans; Infusions, Intravenous; Mitomycin; Neoplasm Invasiveness; Skin Neoplasms; Stomach Neoplasms; Treatment Outcome | 1994 |
[A case of advanced breast cancer with multiple lung metastases responding well to postoperative combined administration of doxifluridine (5'-DFUR) and tamoxifen].
Topics: Adenocarcinoma, Papillary; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Female; Floxuridine; Humans; Lung Neoplasms; Mastectomy, Radical; Remission Induction; Tamoxifen | 1994 |
[Effects of 5'-DFUR against BALB/c retroperitoneal sarcoma with spontaneous liver metastases].
Topics: Animals; Antineoplastic Agents; Female; Floxuridine; Liver Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Retroperitoneal Neoplasms; Sarcoma, Experimental | 1994 |
[A case of inflammatory breast cancer successfully treated with 5'-DFUR and MPA].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Breast Neoplasms; Female; Floxuridine; Humans; Mastectomy, Extended Radical; Mastitis; Medroxyprogesterone Acetate | 1994 |
Differential effects of acyclothymidine, a potent pyrimidine nucleoside phosphorylase inhibitor, on the pharmacokinetics of doxifluridine in rabbits via oral administration.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Chromatography, High Pressure Liquid; Drug Interactions; Floxuridine; Fluorouracil; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rabbits; Uracil | 1993 |
[A comparative study on the serum and tissue 5-FU concentrations in patients with hepatocellular carcinoma after preoperative oral administration of UFT and 5'-DFUR].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Hepatocellular; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Tegafur; Uracil | 1994 |
[A histological observation after a short-term administration of 5'-DFUR and tamoxifen in patients with advanced breast cancer].
Topics: Aged; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Floxuridine; Humans; Middle Aged; Tamoxifen; Treatment Outcome | 1993 |
[Antitumor activity of various cytostatics in mice bearing murine advanced tumors].
Topics: Animals; Antineoplastic Agents; Cachexia; Cyclophosphamide; Drug Screening Assays, Antitumor; Floxuridine; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Inbred DBA; Neoplasm Metastasis; Neoplasm Staging; Neoplasm Transplantation; Neoplasms, Experimental | 1993 |
The significance of preoperative chemotherapy for early gastric carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Preoperative Care; Prognosis; Stomach Neoplasms; Tegafur; Uracil | 1993 |
[Study on the relationship between concentrations of 5-FU and PyNPase activity in tumor tissue during oral 5'-DFUR treatment in patients with advanced colorectal cancer].
Topics: Adenocarcinoma; Administration, Oral; Adult; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1994 |
[Comparison of gastrointestinal toxicity of 5-FU derivatives].
Topics: Administration, Oral; Amine Oxidase (Copper-Containing); Animals; Antineoplastic Agents; Digestive System; Floxuridine; Intestine, Large; Intestine, Small; Male; Mice; Tegafur | 1993 |
[A case of advanced gastric cancer with liver and lung metastasis effectively treated by combined chemo-immunotherapy of MMC, 5'-DFUR, OK-432].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Humans; Immunotherapy; Liver Neoplasms; Lung Neoplasms; Male; Mitomycin; Picibanil; Stomach Neoplasms | 1993 |
Differences in activities and substrate specificity of human and murine pyrimidine nucleoside phosphorylases: implications for chemotherapy with 5-fluoropyrimidines.
Topics: Animals; Floxuridine; Fluorouracil; Humans; Liver; Mice; Placenta; Species Specificity; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 1993 |
Cytokines induce thymidine phosphorylase expression in tumor cells and make them more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Antineoplastic Agents; Blotting, Northern; Cell Division; Colonic Neoplasms; Cytokines; Depression, Chemical; Drug Synergism; Enzyme Induction; Floxuridine; Fluorouracil; Humans; Interferon-gamma; Interleukin-1; RNA, Messenger; Stomach Neoplasms; Thymidine Phosphorylase; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha | 1993 |
Functional effects of a naturally occurring amino acid substitution in human thymidylate synthase.
Topics: Base Sequence; Binding Sites; Floxuridine; Fluorouracil; Histidine; Humans; Hydrogen-Ion Concentration; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Temperature; Tetrahydrofolates; Thymidylate Synthase; Tumor Cells, Cultured; Tyrosine | 1993 |
[A case of long surviving inflammatory breast cancer with bone metastasis, treated by intra-arterial infusion chemotherapy followed by extended mastectomy].
Topics: Bone Neoplasms; Breast Neoplasms; Chemotherapy, Adjuvant; Doxorubicin; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Mastectomy, Extended Radical; Middle Aged; Prognosis; Subclavian Artery; Tamoxifen; Thoracic Arteries | 1993 |
[Preoperative intra-arterial injection of mitoxantrone for locally advanced breast cancer].
Topics: Administration, Oral; Adult; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Humans; Injections, Intra-Arterial; Mastectomy; Middle Aged; Mitoxantrone; Preoperative Care | 1993 |
Solid-phase extraction of fluoropyrimidine derivatives on a copper-modified strong cation exchanger: determination of doxifluridine, 5-fluorouracil and its main metabolites in serum by high-performance liquid chromatography with ultraviolet detection.
Topics: Adsorption; Antineoplastic Agents; Cations; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Copper; Floxuridine; Fluorouracil; Humans; Isomerism; Spectrophotometry, Ultraviolet | 1993 |
[Combination therapy of high dose doxifluridine (5'-DFUR)+mitomycin C (MMC) for advanced or recurrent colorectal cancer. Joint Research Group in the Osaka Area for Combination Therapy of 5'-DFUR with Other Drugs].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Follow-Up Studies; Humans; Injections, Intravenous; Male; Middle Aged; Mitomycin; Neoplasm Recurrence, Local; Rectal Neoplasms; Survival Rate | 1993 |
[A case of bilateral pulmonary metastasis from rectal cancer successfully treated with resection after high-dose 5'-DFUR plus MMC combination chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Female; Floxuridine; Humans; Lung Neoplasms; Middle Aged; Mitomycin; Pneumonectomy; Rectal Neoplasms | 1993 |
[A case of breast cancer with multiple organ metastases in which single low dose administration of 5'-DFUR proved effective].
Topics: Antineoplastic Agents; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis; Mastectomy, Radical; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Metastasis; Prognosis; Quality of Life; Tamoxifen | 1993 |
Cytokines induce uridine phosphorylase in mouse colon 26 carcinoma cells and make the cells more susceptible to 5'-deoxy-5-fluorouridine.
Topics: Animals; Antineoplastic Agents; Cell Division; Colonic Neoplasms; Cytokines; Dose-Response Relationship, Drug; Drug Synergism; Enzyme Induction; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Interferon-gamma; Interleukin-1; Mice; RNA, Neoplasm; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Uridine; Uridine Phosphorylase | 1993 |
[Influences of 5'-deoxy-5-fluorouridine (5'-DFUR) on cell cycle in patients with breast cancer].
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; DNA, Neoplasm; Female; Flow Cytometry; Floxuridine; Humans; Ploidies | 1993 |
[Usefulness of contact thermography for the evaluation of chemotherapeutic effectiveness in breast cancer].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Cyclophosphamide; Doxorubicin; Female; Floxuridine; Humans; Methotrexate; Middle Aged; Mitomycin; Thermography; Vindesine | 1993 |
[A case of recurrent colon cancer treated markedly effective with 5'-DFUR].
Topics: Administration, Oral; Aged; Antineoplastic Agents; Colonic Neoplasms; Floxuridine; Humans; Liver Neoplasms; Lymphatic Metastasis; Male | 1993 |
Antitumor effects of pirarubicin and epirubicin in combination with doxifluridine and cisplatin against mouse P388 leukemia.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Doxorubicin; Drug Screening Assays, Antitumor; Epirubicin; Female; Floxuridine; Leukemia P388; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA | 1995 |
[Successful combination chemotherapy for a post-operative gastric cancer patient with multiple liver metastases and elevated CEA].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Combined Modality Therapy; Doxorubicin; Floxuridine; Gastrectomy; Humans; Liver Neoplasms; Male; Mitomycin; Remission Induction; Stomach Neoplasms | 1996 |
Oral chemotherapy with doxifluridine and folinic acid in biliary tract cancer.
Topics: Adult; Aged; Antidotes; Antineoplastic Agents; Biliary Tract Neoplasms; Drug Therapy, Combination; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged | 1995 |
[A case of hepatocellular carcinoma responding to oral administration of 5'-DFUR].
Topics: Administration, Oral; Aged; alpha-Fetoproteins; Antineoplastic Agents; Carcinoma, Hepatocellular; Female; Floxuridine; Humans; Liver Cirrhosis; Liver Neoplasms; Remission Induction | 1996 |
[A case of nonresectable advanced gastric cancer responding to combined chemotherapy with 5'-DFUR, CDDP, and MMC].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Floxuridine; Humans; Male; Mitomycin; Neoplasm Invasiveness; Stomach Neoplasms | 1996 |
[A case of effective chemotherapy by combination of 5'-DFUR and MMC for recurrent colon cancer with multiple liver metastasis].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Liver Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Mitomycin; Postoperative Period | 1996 |
Modulation of the pharmacokinetics of 5'-deoxy-5-fluorouridine and 5-fluorouracil in rats by oral co-administration of acyclothymidine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Drug Interactions; Enzyme Inhibitors; Floxuridine; Fluorouracil; Intestines; Liver; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Uracil | 1996 |
[A case of recurrent breast cancer responding to long-term treatment with 5'-DFUR combined with MPA].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Recurrence, Local | 1996 |
Comparative immunotoxicity assessment of N4-Trimethoxybenzoyl-5'-deoxy-5- fluorocytidine (Ro 09-1390) and 5'-deoxy-5-fluorouridine (5'-DFUR) in BDF1 mice.
Topics: Animals; Body Weight; Bone Marrow; Corticosterone; Deoxycytidine; Dose-Response Relationship, Drug; Floxuridine; Immunohistochemistry; Immunosuppressive Agents; Isomerism; Male; Mice; Organ Size; Reticulocyte Count; Thymus Gland | 1996 |
[Intra-arterial infusion chemotherapy for liver metastases from breast cancer].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Medroxyprogesterone; Middle Aged | 1996 |
[A case resectable hepatic metastases of breast cancer following intrahepatic arterial chemotherapy].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Female; Floxuridine; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Lymphatic Metastasis; Middle Aged; Mitomycin; Survival Rate; Tamoxifen | 1996 |
Gas chromatography-mass spectrometry identification of a novel N3-methylated metabolite of 5'-deoxy-5-fluorouridine in plasma of cancer patients undergoing chemotherapy.
Topics: Antineoplastic Agents; Chromatography, High Pressure Liquid; Floxuridine; Gas Chromatography-Mass Spectrometry; Humans; Neoplasms; Prodrugs; Reference Standards | 1996 |
Acyclothymidine alleviates intestinal toxicity of 5'-deoxy-5-fluorouridine without loss of antitumor activity in mice.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Body Weight; Carcinoma, Lewis Lung; Drug Synergism; Enzyme Inhibitors; Floxuridine; Intestines; Isomerism; Mice; Thymidine Phosphorylase; Uracil | 1996 |
[Unresectable gastric cancer followed by remarkably effective tumor disappearance and good quality of life for 10 months after CDDP/5'-DFUR combination chemotherapy--a case report].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Cisplatin; Esophageal Neoplasms; Female; Floxuridine; Humans; Infusions, Intravenous; Liver Neoplasms; Lymphatic Metastasis; Neoplasm Invasiveness; Quality of Life; Stomach Neoplasms | 1996 |
Preparation of anti-human thymidine phosphorylase monoclonal antibodies useful for detecting the enzyme levels in tumor tissues.
Topics: Animals; Antibodies, Monoclonal; Enzyme-Linked Immunosorbent Assay; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasms; Thymidine Phosphorylase | 1996 |
[Antimetastatic effects of UFT on murine liver metastasis model using L5178YHM lymphoma].
Topics: Animals; Body Weight; Drug Combinations; Floxuridine; Leukemia L5178; Liver Neoplasms; Male; Mice; Tegafur; Uracil | 1996 |
[A case of advanced gastric cancer that responded to long-term administration of low-dose 5'-DFUR].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis; Stomach Neoplasms | 1997 |
Enhancement of drug sensitivity and a bystander effect in PC-9 cells transfected with a platelet-derived endothelial cell growth factor thymidine phosphorylase cDNA.
Topics: Antineoplastic Agents; Cell Communication; DNA, Complementary; Drug Screening Assays, Antitumor; Floxuridine; Humans; Platelet-Derived Growth Factor; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1997 |
[PyNPase activity in primary and metastatic colorectal cancer].
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Colorectal Neoplasms; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 1997 |
[The relation between pyrimidine nucleoside phosphorylase (PyNPase) activity in colorectal cancer tissues and pathological effects].
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Humans; Male; Middle Aged; Pentosyltransferases; Preoperative Care; Pyrimidine Phosphorylases | 1997 |
Antitumor effects of 5'-deoxy-5-fluorouridine in combination with recombinant human interleukin 2 on murine colon carcinoma 26.
Topics: Animals; Antineoplastic Agents; Cell Division; Cell Line; Colonic Neoplasms; Drug Therapy, Combination; Female; Floxuridine; Humans; Interleukin-2; Isomerism; Mice; Mice, Inbred BALB C; Recombinant Proteins | 1997 |
[Successful 5'-DFUR, CDDP and MMC combination therapy and 5'-DFUR and carboplatin combination therapy for a patient with inoperable advanced gastric cancer with peritonitis carcinomatosa].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Cisplatin; Drug Administration Schedule; Floxuridine; Humans; Male; Mitomycin; Peritonitis; Stomach Neoplasms; Survivors | 1997 |
Inhibitory effects of fluorinated pyrimidines, 5'-DFUR, UFT and T-506, in a model of hepatic metastasis of mouse colon 26 adenocarcinoma-assessment of inhibitory activity and adverse reactions at the maximum tolerated dose.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents; Body Weight; Colonic Neoplasms; Dose-Response Relationship, Drug; Drug Combinations; Female; Floxuridine; Fluorodeoxyuridylate; Liver Neoplasms, Experimental; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Tegafur; Uracil | 1997 |
[Pyrimidine nucleoside phosphorylase activity, 5-fluorouracil concentration and thymidylate synthase inhibition rate in colorectal cancer after oral administration of 5'-doxifluridine].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases; Thymidylate Synthase | 1997 |
[A case of advanced breast cancer receiving combination therapy with 5'-DFUR and MPA with remarkable results].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Papillary; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Lymph Node Excision; Lymphatic Metastasis; Medroxyprogesterone Acetate | 1997 |
[Efficacy of combination chemotherapy of cyclophosphamide and 5'-deoxy-5-fluorouridine in a mammary tumor xenograft model, MX-1].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cell Division; Cyclophosphamide; Drug Synergism; Female; Floxuridine; Humans; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Transplantation, Heterologous | 1997 |
[Combination therapy with 5'-DFUR, MMC and CDDP in patient with far advanced gastric cancer: report of a case].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Floxuridine; Gastrectomy; Humans; Lymph Node Excision; Male; Middle Aged; Mitomycin; Stomach Neoplasms | 1997 |
[Complete tumor regression obtained by chemoendocrine therapy including toremifene in two cases of pulmonary metastasis of breast cancer with a history of tamoxifen treatment].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Floxuridine; Humans; Lung Neoplasms; Middle Aged; Mitomycin; Remission Induction; Tamoxifen; Toremifene | 1997 |
Inhibition of 5'-deoxy-5-fluorouridine phosphorolysis by acyclothymidine in tumor cell homogenates.
Topics: Animals; Antineoplastic Agents; Enzyme Inhibitors; Floxuridine; Humans; Kinetics; Mice; Mice, Inbred C57BL; Thymidine Phosphorylase; Tumor Cells, Cultured; Uracil | 1997 |
[Effect on 5'-deoxy-5-fluorouridine (5'-DFUR) of pyrimidine nucleoside phosphorylase (PyNPase), matrix metalloprotease and serum IAP values. Hokuriku Colorectal Cancer Chemotherapy Study Group].
Topics: Adult; Aged; Antineoplastic Agents; Colonic Neoplasms; Extracellular Matrix; Female; Floxuridine; Humans; Lymphatic Metastasis; Male; Metalloendopeptidases; Middle Aged; Neoplasm Invasiveness; Neoplasm Proteins; Pentosyltransferases; Pyrimidine Phosphorylases; Rectal Neoplasms | 1997 |
Bystander effects in enzyme/prodrug gene therapy.
Topics: Antineoplastic Agents; Floxuridine; Ganciclovir; Gap Junctions; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Neoplasms; Prodrugs; Thymidine Kinase; Thymidine Phosphorylase | 1997 |
Bystander effects of different enzyme-prodrug systems for cancer gene therapy depend on different pathways for intercellular transfer of toxic metabolites, a factor that will govern clinical choice of appropriate regimes.
Topics: Animals; Apoptosis; Cell Communication; Cell Line; Cricetinae; Drug Synergism; Floxuridine; Ganciclovir; Gap Junctions; Genetic Therapy; Genetic Vectors; Herpesvirus 1, Human; Humans; Mice; Neoplasms; Prodrugs; Thymidine Kinase; Thymidine Phosphorylase; Tumor Cells, Cultured | 1997 |
[Efficacy of combination chemotherapy with mitoxantrone, vincristine, doxifluridine and prednisolone for recurrence of breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Intravenous; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Prednisolone; Vincristine | 1997 |
[Successful treatment of hepatic metastasis of gastric cancer with 5'-DFUR and Lentinan].
Topics: Adenocarcinoma; Aged; Antibodies, Neoplasm; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Humans; Lentinan; Liver Neoplasms; Stomach Neoplasms; Thymidine Phosphorylase | 1998 |
Positive correlation between the efficacy of capecitabine and doxifluridine and the ratio of thymidine phosphorylase to dihydropyrimidine dehydrogenase activities in tumors in human cancer xenografts.
Topics: Animals; Antineoplastic Agents; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Mice; Neoplasm Transplantation; Oxidoreductases; Thymidine Phosphorylase | 1998 |
[A CR case of amylase-producing tumor treated by hyperthermochemotherapy].
Topics: Adenocarcinoma; Amylases; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Female; Floxuridine; Humans; Hyperthermia, Induced; Middle Aged; Mitomycin; Neoplasms, Unknown Primary; Peritoneal Neoplasms | 1998 |
[A case of complete response of metastasis of cervical cancer with a combination of CBDCA and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Female; Floxuridine; Humans; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Mediastinum; Middle Aged; Remission Induction; Uterine Cervical Neoplasms | 1998 |
[Successful treatment of pseudomyxoma peritonei using combination chemotherapy of intraperitoneal low-dose CDDP and oral 5'-DFUR administration].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Drug Administration Schedule; Female; Floxuridine; Humans; Injections, Intraperitoneal; Peritoneal Neoplasms; Pseudomyxoma Peritonei | 1998 |
Determination of N3-methyl-5'-deoxy-5-fluorouridine, a novel metabolite of doxifluridine, in body fluids by high performance liquid chromatography.
Topics: Ammonium Sulfate; Antineoplastic Agents; Bromouracil; Chromatography, High Pressure Liquid; Floxuridine; Humans; Prodrugs; Reference Standards; Spectrophotometry, Ultraviolet | 1998 |
Effect of coadministered uridine on intestinal first-pass metabolism of 5'-deoxy-5-fluorouridine in conscious rats--an evaluation by method of portal-systemic concentration difference.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Arteries; Drug Interactions; Floxuridine; Fluorouracil; Intestinal Absorption; Intestinal Mucosa; Intestines; Male; Portal System; Portal Vein; Rats; Rats, Wistar; Uridine | 1998 |
Antitumor activities of a novel fluoropyrimidine, N4-pentyloxycarbonyl-5'-deoxy-5-fluorocytidine (capecitabine).
Topics: Analysis of Variance; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents; Capecitabine; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Mice; Mice, Inbred BALB C; Neoplasm Metastasis; Pyrimidines; Subrenal Capsule Assay | 1998 |
[Intra-arterial injection therapy of mitoxantrone for locally advanced breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Catheters, Indwelling; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Lymphatic Metastasis; Mastectomy; Middle Aged; Mitoxantrone | 1998 |
[Adjuvant intra-arterial chemotherapy with gastrin receptor antagonist after hepatic resection in colorectal cancer metastasis].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Doxorubicin; Drug Administration Schedule; Floxuridine; Hepatectomy; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Mitomycin; Proglumide; Receptors, Cholecystokinin | 1998 |
[Three cases of colorectal cancer with lung metastasis successfully treated with combination chemotherapy using 5'-DFUR and MMC].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Male; Middle Aged; Mitomycin; Quality of Life | 1998 |
[The correlation between thymidine phosphorylase activity of renal cancer cells and the chemosensitivity to 5-FU and 5'-DFUR].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Kidney Neoplasms; Thymidine Phosphorylase; Tumor Cells, Cultured | 1998 |
[Comparative study of 5'-DFUR administration of single time per day versus two or three times].
Topics: Adult; Aged; Antineoplastic Agents; Breast Neoplasms; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Middle Aged | 1998 |
Thymidine phosphorylase activity and prodrug effects in a three-dimensional model of angiogenesis: implications for the treatment of ovarian cancer.
Topics: Adult; Animals; Antineoplastic Agents; Female; Floxuridine; Humans; Isomerism; Microcirculation; Neovascularization, Pathologic; Ovarian Neoplasms; Prodrugs; Rats; Rats, Wistar; Recombinant Proteins; Thymidine Phosphorylase; Tumor Cells, Cultured | 1998 |
[A case of stage IV breast cancer showing long-term complete response to combination therapy with 5'-DFUR and MPA].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Combined Modality Therapy; Female; Floxuridine; Humans; Lymphatic Metastasis; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction | 1998 |
Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue.
Topics: Animals; Capecitabine; Carboxylic Ester Hydrolases; Cytidine Deaminase; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Liver; Male; Mice; Neoplasms; Thymidine Phosphorylase | 1998 |
[A case of giant advanced breast cancer responding remarkably to chemo-endocrine therapy chiefly with doxifluridine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cyclophosphamide; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Pleural Effusion, Malignant; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen | 1998 |
Pharmacokinetic analysis program based on tank-in-series model, MULTI(TIS), for evaluation of capacity-limited local disposition.
Topics: Animals; Dose-Response Relationship, Drug; Floxuridine; In Vitro Techniques; Liver; Male; Oxacillin; Penicillins; Perfusion; Pharmacokinetics; Rats; Rats, Wistar; Software; Time Factors | 1998 |
Uptake of doxifluridine by rabbit small intestinal brush-border membrane vesicles.
Topics: Animals; Antineoplastic Agents; Floxuridine; Hydrogen-Ion Concentration; In Vitro Techniques; Intestine, Small; Intracellular Membranes; Microvilli; Rabbits | 1998 |
Enhancement of 5-fluorouracil cytotoxicity by human thymidine-phosphorylase expression in cancer cells: in vitro and in vivo study.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinoma; Colonic Neoplasms; Drug Synergism; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Neoplasm Proteins; Thymidine Phosphorylase; Transfection | 1999 |
Effects of sex steroids and growth factors on invasive activity and 5'-deoxy-5-fluorouridine sensitivity in ovarian adenocarcinoma OMC-3 cells.
Topics: Basement Membrane; Cell Division; Cell Movement; Collagenases; Culture Media, Conditioned; Cystadenocarcinoma, Mucinous; Drug Resistance, Neoplasm; Enzyme Induction; Epidermal Growth Factor; ErbB Receptors; Estradiol; Female; Fibronectins; Floxuridine; Humans; Matrix Metalloproteinase 3; Neoplasm Invasiveness; Neoplasm Proteins; Ovarian Neoplasms; Prodrugs; Progesterone; Receptors, Estrogen; Receptors, Progesterone; Thymidine Phosphorylase; Transforming Growth Factor alpha; Tumor Cells, Cultured; Urokinase-Type Plasminogen Activator | 1998 |
[Interferons alpha-2a and gamma increase the antitumor activity, detected by histoculture drug response assay, of doxifluridine against clinical renal cell cancers].
Topics: Antineoplastic Agents; Cell Death; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Interferon-gamma; Kidney Neoplasms; Recombinant Proteins | 1999 |
[Comparative study of 5'-deoxy-5-fluorouridine between older cancer patients versus younger cancer patients].
Topics: Adult; Age Factors; Aged; Aged, 80 and over; Antineoplastic Agents; Breast Neoplasms; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Male; Middle Aged; Stomach Neoplasms | 1999 |
Prediction of response to 5'-deoxy-5-fluorouridine (5'-DFUR) in patients with inoperable advanced gastric cancer by immunostaining of thymidine phosphorylase/platelet-derived endothelial cell growth factor.
Topics: Adult; Aged; Antibodies, Monoclonal; Antineoplastic Agents; Female; Floxuridine; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Humans; Male; Middle Aged; Predictive Value of Tests; Regression Analysis; Stomach Neoplasms; Thymidine Phosphorylase; Treatment Outcome | 1999 |
Pharmacokinetics and bioavailability of oral 5'-deoxy-5-fluorouridine in cancer patients.
Topics: Administration, Oral; Adult; Aged; Antineoplastic Agents; Biological Availability; Female; Floxuridine; Humans; Middle Aged; Neoplasms | 1999 |
Enhancement of the anti-tumor effect of 5'-deoxy-5-fluorouridine by transfection of thymidine phosphorylase gene into human colon cancer cells.
Topics: Animals; Antineoplastic Agents; Colonic Neoplasms; Combined Modality Therapy; Feasibility Studies; Floxuridine; Genetic Therapy; Humans; Mice; Mice, Nude; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1999 |
[Combination of 5'-DFUR and MMC for recurrent rectal cancer with pulmonary metastasis].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Floxuridine; Humans; Lung Neoplasms; Male; Mitomycin; Rectal Neoplasms | 1999 |
[Effective chemo-endocrine combination therapy for obstructive-jaundice caused by multiple liver metastasis of recurrent breast cancer--a case report].
Topics: Aged; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cholestasis; Cyclophosphamide; Doxorubicin; Drainage; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Mastectomy, Radical; Medroxyprogesterone Acetate; Tamoxifen; Tegafur; Toremifene; Uracil | 1999 |
[Endocrine chemotherapy (high-dose toremifene + 5'-DFUR) found markedly effective for 2 cases of metastatic breast cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Female; Floxuridine; Humans; Lung Neoplasms; Middle Aged; Remission Induction; Toremifene | 1999 |
[A case of gastric carcinoma treated effectively with 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Agents; Cardia; Drug Administration Schedule; Floxuridine; Humans; Male; Stomach Neoplasms; Thymidine Phosphorylase | 1999 |
[A case of breast cancer with liver metastases responding remarkably to combination therapy of mitoxantrone (MIT), doxifluridine (5'-DFUR) and medroxyprogesterone acetate (MPA)].
Topics: Administration, Oral; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Resistance, Neoplasm; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Medroxyprogesterone Acetate; Middle Aged; Mitoxantrone; Tamoxifen | 1999 |
Induction of thymidine phosphorylase expression and enhancement of efficacy of capecitabine or 5'-deoxy-5-fluorouridine by cyclophosphamide in mammary tumor models.
Topics: Animals; Antineoplastic Agents; Antineoplastic Agents, Alkylating; Antineoplastic Combined Chemotherapy Protocols; Body Weight; Capecitabine; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; Kinetics; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasm Transplantation; Thymidine Phosphorylase; Time Factors; Up-Regulation | 1999 |
Increased cytotoxicity and bystander effect of 5-fluorouracil and 5-deoxy-5-fluorouridine in human colorectal cancer cells transfected with thymidine phosphorylase.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Survival; Cloning, Molecular; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Humans; Recombinant Proteins; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 1999 |
UFT and its metabolites inhibit the angiogenesis induced by murine renal cell carcinoma, as determined by a dorsal air sac assay in mice.
Topics: 4-Butyrolactone; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Cell Division; Diffusion Chambers, Culture; Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Hydroxybutyrates; Kidney Neoplasms; Male; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Neovascularization, Pathologic; Tegafur; Tumor Cells, Cultured; Uracil | 1999 |
[Evaluation of antitumor activity of etoposide administered orally for 21 consecutive days against human uterine cancer subcutaneous and/or orthotopic xenografts in nude mice].
Topics: Adenocarcinoma; Administration, Oral; Animals; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Carcinoma, Squamous Cell; Cisplatin; Etoposide; Female; Floxuridine; Humans; Irinotecan; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Skin; Transplantation, Heterologous; Uterine Neoplasms | 1999 |
[A case of adriamycin and methotrexate-resistant recurrent breast cancer treated with doxifluridine and mitomycin C].
Topics: Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Doxorubicin; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Lymphatic Metastasis; Methotrexate; Middle Aged; Mitomycin; Neoplasm Recurrence, Local | 1999 |
[A breast cancer patient with docetaxel-resistant pleural recurrence with remarkable response to doxifluridine and cyclophosphamide].
Topics: Administration, Oral; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Breast Neoplasms; Cranial Irradiation; Cyclophosphamide; Docetaxel; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Middle Aged; Neoadjuvant Therapy; Paclitaxel; Pleural Neoplasms; Quality of Life; Taxoids | 1999 |
Chemoradiotherapy as preoperative treatment in locally advanced unresectable pancreatic cancer patients: results of a feasibility study.
Topics: Adult; Aged; Antidotes; Antineoplastic Agents; Combined Modality Therapy; Disease Progression; Feasibility Studies; Female; Floxuridine; Humans; Leucovorin; Male; Middle Aged; Neoplasm Staging; Pancreatectomy; Pancreatic Neoplasms; Survival Rate | 1999 |
[Doxifluridine decreases serum levels of interleukin-6 in a cancer cachexia model].
Topics: Animals; Antineoplastic Agents; Breast Neoplasms; Cachexia; Cell Division; Female; Floxuridine; Humans; Interleukin-6; Mice; Mice, Nude; Neoplasm Transplantation; Pentosyltransferases; Pyrimidine Phosphorylases; Tumor Cells, Cultured | 1999 |
Augmentation of antitumor activity of 5'-deoxy-5-fluorouridine by thymosin fraction 5 in mouse bladder cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; Immunosuppressive Agents; Male; Mice; Mice, Inbred C3H; Prodrugs; Thymosin; Tumor Cells, Cultured; Urinary Bladder Neoplasms | 1999 |
[Successful endocrine chemotherapy in patients with multiple bone metastases of breast cancer--a case report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone; Middle Aged; Tamoxifen | 1999 |
[A case of intra-arterial infusion chemotherapy for liver metastases of breast cancer].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Papillary; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Hepatic Artery; Humans; Infusion Pumps, Implantable; Infusions, Intra-Arterial; Liver Neoplasms; Medroxyprogesterone; Middle Aged | 1999 |
[Successful treatment of pleuritis carcinomatosa using combination therapy of 5'-DFUR, MPA and CPA as maintenance therapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Pleurisy | 1999 |
[Long-term complete response in a case of unresectable rectal cancer following chemoradiation].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Remission Induction; Tegafur; Uracil | 2000 |
[A case of diffusely infiltrating carcinoma of the sigmoid colon associated with lymphangitis carcinomatosa effectively treated with sequential MTX.5-FU and 5'-DFUR].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Floxuridine; Fluorouracil; Humans; Lymphangitis; Male; Methotrexate; Sigmoid Neoplasms | 2000 |
[Case report of a patient with invading bladder cancer and lymph node swelling which decreased following 5'-DFUR treatment].
Topics: Aged; Antineoplastic Agents; Child, Preschool; Floxuridine; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Neoplasm Invasiveness; Urinary Bladder Neoplasms | 2000 |
[A case of recurrent breast cancer with carcinoma erysipeloides responding to sequential therapy with docetaxel (TXT) and doxifluridine (5'-DFUR) accompanied by leucovorin (LV)].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma; Cyclophosphamide; Docetaxel; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Injections, Intra-Arterial; Leucovorin; Mastectomy; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Skin Neoplasms; Taxoids | 2000 |
[Pain relief with alendronate therapy in a breast cancer patient with bone metastasis].
Topics: Aged; Alendronate; Antineoplastic Agents; Antineoplastic Agents, Hormonal; Bone Neoplasms; Breast Neoplasms; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Pain; Sternum | 2000 |
[Efficacy of combined chemoendocrine therapy with doxifluridine, cyclophosphamide, and fadrozole hydrochloride hydrate in a case of stage T4N3M1 breast cancer].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Fadrozole; Female; Floxuridine; Humans; Lymphatic Metastasis | 2000 |
Effect of a fluorinated pyrimidine on cachexia and tumour growth in murine cachexia models: relationship with a proteolysis inducing factor.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Appetite Stimulants; Blood Proteins; Body Weight; Cachexia; Clone Cells; Colonic Neoplasms; Female; Floxuridine; Humans; Interleukin-6; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Mice, Nude; Muscle Proteins; Neoplasm Proteins; Neoplasm Transplantation; Proteoglycans; Transplantation, Heterologous; Tumor Cells, Cultured; Uterine Cervical Neoplasms | 2000 |
Prolonged stable disease effects survival in patients with solid gastric tumor: analysis of phase II studies of doxifluridine.
Topics: Antimetabolites, Antineoplastic; Clinical Trials, Phase II as Topic; Disease Progression; Floxuridine; Humans; Multicenter Studies as Topic; Stomach Neoplasms; Survival Analysis | 2000 |
[Comparison of pharmacokinetics of 5-FU and alpha-fluoro-beta-alanine, a metabolite of 5-FU, in plasma after administration of UFT, tegafur, 5-FU or doxifluridine to rats].
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; beta-Alanine; Floxuridine; Fluorouracil; Male; Rats; Rats, Sprague-Dawley; Tegafur; Uracil | 2000 |
[A patient with multiple pulmonary metastases from colonic cancer who survived for 5 years by effectual administration of 5'-DFUR].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Carcinoembryonic Antigen; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms | 2000 |
[Chemotherapy with mitoxantrone for the treatment of recurrent breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Medroxyprogesterone Acetate; Middle Aged; Mitoxantrone; Neoplasm Recurrence, Local; Vincristine | 2000 |
[A case of effective bisphosphonate therapy of sequential pamidronate and incadronate for bone metastases from breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Diphosphonates; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Pamidronate | 2000 |
Disposition and availability of 5-fluorouracil prodrug 5'-deoxy-5-fluorouridine after oral administration in rats.
Topics: Absorption; Administration, Oral; Animals; Antimetabolites, Antineoplastic; Biological Availability; Female; Floxuridine; Fluorouracil; Prodrugs; Rats; Rats, Inbred F344 | 1987 |
Intratumoral pyrimidine nucleoside phosphorylase (PyNPase) activity predicts a selective effect of adjuvant 5'-deoxy-5-fluorouridine (5'DFUR) on breast cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Chromatography, High Pressure Liquid; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Lymphatic Metastasis; Mastectomy, Radical; Menopause; Middle Aged; Mitomycin; Neoplasm Proteins; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Tamoxifen; Thymidine Phosphorylase; Treatment Outcome | 2000 |
A case of metastatic breast cancer achieving complete response by combination therapy with 5'-deoxy-5-fluorouridine and cyclophosphamide.
Topics: Antineoplastic Combined Chemotherapy Protocols; Biotransformation; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Cyclophosphamide; Female; Floxuridine; Humans; Lung Neoplasms; Lymphatic Metastasis; Mastectomy, Modified Radical; Middle Aged; Neoplasm Proteins; Neoplasm Recurrence, Local; Prodrugs; Remission Induction; Thymidine Phosphorylase | 2000 |
[Two patients with liver metastasis from gastric cancer who responded remarkably to combined therapy of 5'-DFUR and PSK].
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Female; Floxuridine; Gastrectomy; Humans; Liver Neoplasms; Middle Aged; Pentosyltransferases; Proteoglycans; Pyrimidine Phosphorylases; Remission Induction; Stomach Neoplasms | 2000 |
Correlation between elevated intratumoral thymidine phosphorylase and prognosis of node-positive breast carcinoma undergoing adjuvant doxifluridine treatment.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, Breast; Chemotherapy, Adjuvant; Combined Modality Therapy; Disease-Free Survival; Enzyme Inhibitors; Estrogens; Female; Floxuridine; Genes, erbB-2; Humans; Life Tables; Lymphatic Metastasis; Middle Aged; Neoplasm Proteins; Neoplasms, Hormone-Dependent; Progesterone; Prognosis; Receptors, Estrogen; Receptors, Progesterone; Survival Analysis; Thymidine Phosphorylase | 2000 |
[A case of locally advanced rectal carcinoma with liver metastasis treated with a combination of CRT, HAI, and systemic chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Cimetidine; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Radiotherapy Dosage; Rectal Neoplasms; Suppositories | 2000 |
[A case of advanced breast cancer that responded remarkably to chemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone Acetate; Middle Aged | 2000 |
[A case of breast cancer with multiple organ metastases responding remarkably to combination therapy of CAF (cyclophosphamide, adriamycin and 5-FU), 5'-DFUR and MPA (medroxyprogesterone acetate)].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction | 2000 |
[Effectiveness of high-dose, intermittent 5'-DFUR therapy for advanced gastric cancer].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Dose-Response Relationship, Drug; Drug Administration Schedule; Floxuridine; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Peritoneal Neoplasms; Stomach Neoplasms | 2001 |
[Survival of 2 years and 7 months with 5'-DFUR treatment in a patient with peritoneal gastric cancer recurrence].
Topics: Aged; Antimetabolites, Antineoplastic; Drug Administration Schedule; Floxuridine; Humans; Male; Peritoneal Neoplasms; Stomach Neoplasms; Survivors | 2001 |
[Weekly low dose CPT-11 for multiple lung metastases of colon cancer on an out-patient treatment: a case report].
Topics: Adult; Ambulatory Care; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Lung Neoplasms | 2001 |
[Advanced breast cancer with multiple bone metastases successfully treated with combined chemoendocrine-therapy of CEF (cyclophosphamide, epirubicin, 5-fluorouracil) and 5'-DFUR (5'-deoxy-5-fluorouridine) + MPA (medroxyprogesterone acetate)--a case report
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Therapy, Combination; Epirubicin; Female; Floxuridine; Fluorouracil; Humans; Medroxyprogesterone; Middle Aged; Progesterone Congeners; Treatment Outcome | 2001 |
Enhancement of sensitivity to capecitabine in human renal carcinoma cells transfected with thymidine phosphorylase cDNA.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Renal Cell; Cell Survival; Deoxycytidine; Disease Models, Animal; DNA, Complementary; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Kidney Neoplasms; Mice; Mice, Inbred BALB C; Mice, Nude; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured; Xenograft Model Antitumor Assays | 2001 |
Schedule dependency of antitumor activity in combination therapy with capecitabine/5'-deoxy-5-fluorouridine and docetaxel in breast cancer models.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Deoxycytidine; Disease Models, Animal; Docetaxel; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Nude; Paclitaxel; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation; Xenograft Model Antitumor Assays | 2001 |
Role of the human concentrative nucleoside transporter (hCNT1) in the cytotoxic action of 5[Prime]-deoxy-5-fluorouridine, an active intermediate metabolite of capecitabine, a novel oral anticancer drug.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Capecitabine; Carrier Proteins; Cell Survival; CHO Cells; Cloning, Molecular; Cricetinae; Deoxycytidine; DNA, Complementary; Drug Screening Assays, Antitumor; Fetus; Floxuridine; Fluorouracil; Humans; Liver; Membrane Transport Proteins; Oocytes; Prodrugs; Transfection; Xenopus laevis | 2001 |
Impact of thymidine phosphorylase surexpression on fluoropyrimidine activity and on tumour angiogenesis.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Formazans; Neoplasm Transplantation; Neovascularization, Pathologic; Pentosyltransferases; Pyrimidine Phosphorylases; Rats; Tetrazolium Salts; Thymidine Phosphorylase; Transfection; Tumor Cells, Cultured | 2001 |
Three-dimensional organization of the hepatic microvasculature in hereditary hemorrhagic telangiectasia.
Topics: Adenocarcinoma; Aged; Aged, 80 and over; Angiography; Antimetabolites, Antineoplastic; Autopsy; Biopsy, Needle; Female; Floxuridine; Heart Failure; Hepatic Artery; Hepatic Encephalopathy; Humans; Image Processing, Computer-Assisted; Liver; Liver Neoplasms; Microcirculation; Telangiectasia, Hereditary Hemorrhagic | 2001 |
Thymidine phosphorylase expression is useful in selecting adjuvant chemotherapy for stage III gastric cancer.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Thymidine Phosphorylase; Treatment Outcome | 2001 |
Docetaxel alone or orally combined with 5-fluorouracil and its derivatives: effects on mouse mammary tumor cell line MM2 in vitro and in vivo.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Docetaxel; Drug Synergism; Female; Floxuridine; Fluorouracil; Mammary Neoplasms, Experimental; Mice; Mice, Inbred C3H; Paclitaxel; Prodrugs; Taxoids; Thymidine Phosphorylase; Tumor Cells, Cultured; Up-Regulation | 2001 |
[A patient with recurrent breast cancer whose liver metastasis regressed following combined use of weekly docetaxel and MPA.5'-DFUR].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Docetaxel; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Liver Neoplasms; Medroxyprogesterone Acetate; Paclitaxel; Taxoids | 2001 |
[Effect of peroral doxifluridine plus hepatic arterial infusion for synchronous liver metastasis of colorectal cancer--correlation with the expression of thymidine phosphorylase and dihydropyrimidine dehydrogenase in primary colorectal cancer lesions].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colorectal Neoplasms; Dihydrouracil Dehydrogenase (NADP); Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Male; Middle Aged; Oxidoreductases; Survival Rate; Thymidine Phosphorylase | 2001 |
Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts.
Topics: Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Cachexia; Docetaxel; Drug Interactions; Female; Floxuridine; Gene Expression Regulation, Neoplastic; Humans; Interleukin-6; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Paclitaxel; Taxoids; Tegafur; Thymidine Phosphorylase; Transplantation, Heterologous; Tumor Cells, Cultured | 2001 |
Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine.
Topics: Administration, Oral; Animals; Antineoplastic Agents; Carcinoma, Ehrlich Tumor; Drug Combinations; Floxuridine; Fluorouracil; Intestinal Mucosa; Leukemia L1210; Male; Mice; Tegafur; Uracil | 2001 |
[Hepatic infusion of docetaxel using PEIT for a patient with stage IV breast cancer].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Cyclophosphamide; Docetaxel; Drug Administration Schedule; Ethanol; Fadrozole; Female; Floxuridine; Hepatic Artery; Humans; Infusions, Intra-Arterial; Injections, Intralesional; Liver Neoplasms; Middle Aged; Paclitaxel; Taxoids | 2001 |
[A case of lung metastasis from colon cancer treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Colonic Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Lung Neoplasms; Middle Aged | 2001 |
Immunohistochemical variation of human equilibrative nucleoside transporter 1 protein in primary breast cancers.
Topics: Affinity Labels; Animals; Antibodies, Monoclonal; Antibody Formation; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Carcinoma, Ductal, Breast; Carcinoma, Lobular; Deoxycytidine; Drug Resistance, Neoplasm; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Fluorouracil; Humans; Immunoenzyme Techniques; Membrane Transport Proteins; Mice; Neoplasm Invasiveness; Neoplasm Proteins; Neoplasm Staging; Thioinosine | 2002 |
[A 5'-DFUR + CPA + THP therapy that was effective for paclitaxel-refractory pulmonary metastasis of breast cancer--a case report].
Topics: Adult; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Lung Neoplasms; Paclitaxel | 2002 |
[Antimetastatic and antitumor effects of fluoropyrimidines alone and combined with taxanes in a murine model of breast cancer metastatic to the lung].
Topics: Aminoacridines; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Bridged-Ring Compounds; Disease Models, Animal; Drug Combinations; Female; Floxuridine; Humans; Lung Neoplasms; Mice; Mice, Inbred ICR; Mice, SCID; Neoplasm Transplantation; Taxoids; Tegafur; Uracil | 2002 |
[A case of long surviving advanced recurrent breast cancer with multiple bone metastases responding to treatment with 5'-DFUR combined with MPA].
Topics: Adenocarcinoma, Scirrhous; Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Mastectomy, Radical; Medroxyprogesterone; Survivors | 2002 |
gamma-Hydroxybutyric acid and 5-fluorouracil, metabolites of UFT, inhibit the angiogenesis induced by vascular endothelial growth factor.
Topics: Angiogenesis Inhibitors; Animals; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma; Carcinoma, Renal Cell; Chemotaxis; Colonic Neoplasms; DNA Replication; Drug Combinations; Endothelial Growth Factors; Endothelium, Vascular; Female; Fibroblast Growth Factor 2; Floxuridine; Fluorouracil; Humans; Intercellular Signaling Peptides and Proteins; Kidney Neoplasms; Lung Neoplasms; Lymphokines; Mice; Mice, Inbred BALB C; Mice, Inbred ICR; Neoplasm Proteins; Neovascularization, Pathologic; Prodrugs; Prostheses and Implants; Recombinant Proteins; Sodium Oxybate; Stomach Neoplasms; Tegafur; Tumor Cells, Cultured; Uracil; Vascular Endothelial Growth Factor A; Vascular Endothelial Growth Factors; Xenograft Model Antitumor Assays | 2001 |
[Successful treatment of advanced recurent breast cancer using DMpC therapy as maintenance therapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Neoplasm Recurrence, Local | 2002 |
Overexpression of pyrimidine nucleoside phosphorylase enhances the sensitivity to 5'-deoxy-5-fluorouridine in tumour cells in vitro and in vivo.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasms; Combined Modality Therapy; DNA, Complementary; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Female; Floxuridine; Fluorouracil; Genetic Therapy; Humans; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Pentosyltransferases; Prodrugs; Pyrimidine Phosphorylases; Transfection; Tumor Cells, Cultured | 2002 |
[A case report of effective chemoradiation with 5'-DFUR and concomitant preoperative radiotherapy of the lower rectum].
Topics: Adenocarcinoma; Antimetabolites, Antineoplastic; Drug Administration Schedule; Female; Floxuridine; Humans; Middle Aged; Preoperative Care; Rectal Neoplasms | 2002 |
Probable metabolic interaction of doxifluridine with phenytoin.
Topics: Anticonvulsants; Antimetabolites, Antineoplastic; Antineoplastic Agents, Alkylating; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Brain Neoplasms; Cyclophosphamide; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Interactions; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Phenytoin | 2002 |
[A case of breast cancer with multiple bone metastases that responded remarkably to doxifluridine (5'-DFUR), cyclophosphamide (CPA), medroxyprogesterone acetate (MPA) and pamidronate disodium therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Diphosphonates; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Pamidronate; Quality of Life | 2002 |
[The antitumor activity of DPD inhibitory-fluoropyrimidine (DIF) and non-DIF alone or in combination with paclitaxel against orthotopically implanted human breast cancer].
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Humans; Mice; Mice, Inbred ICR; Neoplasm Transplantation; Oxidoreductases; Paclitaxel; Pyrimidines; Tegafur; Uracil | 2002 |
Metastatic urothelial cancer showing an efficacy by low-dose cisplatin.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Floxuridine; Humans; Infusions, Intravenous; Lymphatic Metastasis; Male; Outpatients; Radiography; Ureteral Neoplasms; Urothelium | 2002 |
Thymidine phosphorylase activity in renal cell carcinoma: relationship between histological parameters and chemosensitivity to fluorouracil-related drugs.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Renal Cell; Floxuridine; Fluorouracil; Humans; Kidney; Kidney Neoplasms; Reference Values; Thymidine Phosphorylase | 2002 |
[A case of colon cancer with multiple liver metastases and lymph nodes metastases successfully treated by 5'-deoxy-5-fluorouridine].
Topics: Administration, Oral; Aged; Antimetabolites, Antineoplastic; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Hepatectomy; Humans; Liver Neoplasms; Lymphatic Metastasis; Male | 2002 |
[One case of locally advanced breast cancer in which multidisciplinary treatment, chiefly, therapy with preoperative intraarterial infusion of docetaxel (TXT), was successful].
Topics: Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Docetaxel; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Medroxyprogesterone Acetate; Middle Aged; Neoadjuvant Therapy; Paclitaxel; Taxoids | 2002 |
[A case of multiple skin metastases from gastric cancer successfully treated with docetaxel combined with doxifluridine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Administration Schedule; Floxuridine; Gastrectomy; Humans; Male; Paclitaxel; Skin Neoplasms; Splenectomy; Stomach Neoplasms; Taxoids | 2002 |
[A case of recurrent gastric cancer that responded dramatically to docetaxel and 5'-DFUR combination chemotherapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Docetaxel; Drug Administration Schedule; Floxuridine; Fluorouracil; Gastrectomy; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Paclitaxel; Pancreatic Neoplasms; Stomach Neoplasms; Taxoids; Treatment Outcome | 2002 |
[A case of colon metastasis to the lung treated successfully with combined chemotherapy of CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Humans; Irinotecan; Lung Neoplasms; Male; Middle Aged; Rectal Neoplasms; Tegafur; Uracil | 2002 |
Expression of extracellular signal-regulated kinase and its relationship with clinicopathological characteristics of breast cancer.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Female; Floxuridine; Humans; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Staging | 2002 |
Cytosolic and microsomal activation of doxifluridine and tegafur to produce 5-fluorouracil in human liver.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Aryl Hydrocarbon Hydroxylases; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2A6; Cytochrome P-450 Enzyme System; Cytosol; Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Mixed Function Oxygenases; Steroid Hydroxylases; Tegafur; Thymidine Phosphorylase | 2002 |
Role of thymidine phosphorylase and dihydropyrimidine dehydrogenase in tumour progression and sensitivity to doxifluridine in gastric cancer patients.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Dihydrouracil Dehydrogenase (NADP); Disease Progression; Enzyme-Linked Immunosorbent Assay; Female; Floxuridine; Humans; Male; Middle Aged; Oxidoreductases; Stomach Neoplasms; Survival Analysis; Thymidine Phosphorylase | 2002 |
Effectiveness of doxifluridine (5'-DFUR)/docetaxel against advanced/recurrent gastric cancer showing resistance to various anticancer drug regimens.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Drug Resistance, Neoplasm; Fatal Outcome; Floxuridine; Gastrectomy; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Stomach Neoplasms; Taxoids | 2002 |
Penetration of capecitabine and its metabolites into malignant and healthy tissue of patients with advanced breast cancer.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Electrophoresis, Capillary; Extracellular Space; Floxuridine; Fluorouracil; Humans; Prodrugs; Skin Neoplasms; Tissue Distribution | 2002 |
Subconjunctival doxifluridine administration suppresses rat choroidal neovascularization through activated thymidine phosphorylase.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Choroidal Neovascularization; Chromatography, High Pressure Liquid; Conjunctiva; Disease Models, Animal; Enzyme Activation; Female; Floxuridine; Fluorescein Angiography; Injections; Rats; Rats, Inbred BN; Thymidine Phosphorylase | 2003 |
[Optimal dosing schedule in combination therapy with irinotecan and doxifluridine in a human colorectal cancer xenograft model].
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Colorectal Neoplasms; Dose-Response Relationship, Drug; Drug Administration Schedule; Floxuridine; Humans; Irinotecan; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation | 2003 |
[A case of advanced recurrent breast cancer responding to treatment with weekly docetaxel combined with doxorubicin].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Docetaxel; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Lymphatic Metastasis; Mastectomy, Modified Radical; Medroxyprogesterone Acetate; Middle Aged; Paclitaxel; Skin Neoplasms; Taxoids | 2003 |
Depression of phenytoin metabolic capacity by 5-fluorouracil and doxifluridine in rats.
Topics: Animals; Anticonvulsants; Antimetabolites, Antineoplastic; Cytochrome P-450 Enzyme System; Down-Regulation; Drug Interactions; Floxuridine; Fluorouracil; Male; Microsomes, Liver; Phenytoin; Rats; Rats, Sprague-Dawley | 2003 |
Effects of introduction of dThdPase cDNA on sensitivity to 5'-deoxy-5-fluorouridine and tumor angiogenesis.
Topics: Breast Neoplasms; Cell Line; Cell Line, Tumor; Cell Survival; DNA, Complementary; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Floxuridine; Genetic Vectors; Humans; Immunohistochemistry; Inhibitory Concentration 50; Neoplasm Transplantation; Neovascularization, Pathologic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrazolium Salts; Thiazoles; Thymidine Phosphorylase; Time Factors; Transfection | 2003 |
Massive mucinous carcinoma of the breast untreated for 6 years.
Topics: Adenocarcinoma, Mucinous; Biopsy, Needle; Breast Neoplasms; Chemotherapy, Adjuvant; Female; Floxuridine; Follow-Up Studies; Humans; Immunohistochemistry; Mastectomy; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Skin Neoplasms; Skin Ulcer; Time Factors; Tomography, X-Ray Computed; Treatment Outcome | 2003 |
Preparation and characterization of chitosan microspheres containing doxifluridine.
Topics: Animals; Antimetabolites, Antineoplastic; Chemistry, Pharmaceutical; Chitin; Chitosan; Drug Implants; Floxuridine; Fluorouracil; Male; Mice; Microspheres; Rats; Rats, Wistar; Tegafur | 2003 |
[Evaluation of weekly paclitaxel and doxifluridine (5'-DFUR) combination therapy in patients with advanced or recurrent breast cancer].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Humans; Leukopenia; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Pilot Projects | 2003 |
[Oral combination chemotherapy of 5'-deoxy-5-fluorouridine (furtulon) and cyclophosphamide for advanced breast cancer].
Topics: Administration, Oral; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Floxuridine; Humans; Middle Aged | 2003 |
[A case of liver metastasis of colon cancer demonstrating complete remission with combination chemotherapy of 5'-DFUR and MMC].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Hepatectomy; Humans; Liver Neoplasms; Male; Mitomycin; Remission Induction | 2003 |
Functional analysis of the EWS/ETS target gene uridine phosphorylase.
Topics: 3T3 Cells; Animals; DNA; Floxuridine; Humans; Mice; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Protein Structure, Tertiary; Proto-Oncogene Protein c-fli-1; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-ets; ras Proteins; Recombinant Fusion Proteins; RNA-Binding Protein EWS; Transcription Factors; Transcription, Genetic; Transfection; Up-Regulation; Uridine Phosphorylase | 2003 |
[A case of multiple lung metastases of colon cancer with long-term survival following 5'-DFUR and cimetidine therapy].
Topics: Adenocarcinoma; Adjuvants, Immunologic; Aged; Antimetabolites, Antineoplastic; Cimetidine; Colonic Neoplasms; Drug Therapy, Combination; Female; Floxuridine; Histamine H2 Antagonists; Humans; Lung Neoplasms | 2003 |
[Effect of preoperative oral 5'-DFUR on PyNPase level in gastrointestinal malignant tumor tissues].
Topics: Administration, Oral; Adult; Aged; Combined Modality Therapy; Female; Floxuridine; Gastrointestinal Neoplasms; Humans; Immunohistochemistry; Male; Middle Aged; Pentosyltransferases; Pyrimidine Phosphorylases | 2003 |
[PyNPase and DPD expression potentially predict response to 5'-DFUR treatment for node-positive breast cancer patients].
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Carcinoma, Ductal, Breast; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Humans; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Oxidoreductases; Pentosyltransferases; Pyrimidine Phosphorylases; Receptors, Estrogen; Receptors, Progesterone | 2003 |
ZD1839 (Iressa) modifies the activity of key enzymes linked to fluoropyrimidine activity: rational basis for a new combination therapy with capecitabine.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Cycle; Cell Division; Cell Line, Tumor; Cell Survival; Deoxycytidine; DNA Primers; Floxuridine; Fluorouracil; Gefitinib; Head and Neck Neoplasms; Humans; Models, Chemical; Polymerase Chain Reaction; Pyrimidines; Quinazolines; RNA; RNA, Messenger; Time Factors; Transcription, Genetic | 2003 |
[A case of multiple liver metastases of colon cancer with PyNPase-positive successfully treated with 5'-DFUR].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colectomy; Colonic Neoplasms; Combined Modality Therapy; Floxuridine; Humans; Liver Neoplasms; Male; Pentosyltransferases; Pyrimidine Phosphorylases; Remission Induction | 2003 |
[A case of hepatic metastasis and local recurrence from rectal cancer responding to hepatic arterial infusion and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Floxuridine; Fluorouracil; Hepatic Artery; Humans; Infusions, Intra-Arterial; Irinotecan; Leucovorin; Liver Neoplasms; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Tegafur; Uracil | 2003 |
In vivo monitoring of capecitabine metabolism in human liver by 19fluorine magnetic resonance spectroscopy at 1.5 and 3 Tesla field strength.
Topics: Aged; Antimetabolites, Antineoplastic; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorine; Fluorouracil; Humans; Liver; Liver Neoplasms; Magnetic Resonance Spectroscopy; Male; Middle Aged; Prodrugs | 2003 |
A case of chest wall recurrence of breast cancer treated with paclitaxel weekly, 5'-deoxy-5-fluorouridine, arterial embolization and chest wall resection.
Topics: Angiography; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal; Embolization, Therapeutic; Female; Floxuridine; Humans; Middle Aged; Paclitaxel; Plastic Surgery Procedures; Thoracic Wall; Tomography, X-Ray Computed | 2003 |
[A case of advanced breast cancer with multiple lung, bone and lymph node metastases successfully treated with 5'-DFUR alone].
Topics: Aged; Antimetabolites, Antineoplastic; Bone Neoplasms; Breast Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Mastectomy, Simple | 2003 |
Positive response to oral chemoendocrine combination therapy using 5"-deoxy-5-fluorouridine for locally advanced breast cancer with carcinomatous pleurisy: report of a case.
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Breast Neoplasms; Drug Therapy, Combination; Endocrine System; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Recurrence, Local; Pleural Effusion, Malignant; Quality of Life; Tamoxifen | 2003 |
[A case of breast cancer with lung and bone metastasis treated successfully by oral combination chemotherapy of 5'-deoxy-5-fluorouridine and cyclophosphamide].
Topics: Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Combined Modality Therapy; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Lung Neoplasms; Mastectomy, Segmental; Middle Aged; Quality of Life | 2003 |
[Two cases of metastatic or recurrent rectal cancer responding to combined chemotherapy of low-dose CPT-11 and 5'-DFUR as second-line chemotherapy].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Dose-Response Relationship, Drug; Drug Administration Schedule; Floxuridine; Humans; Infusions, Intravenous; Irinotecan; Liver Neoplasms; Male; Middle Aged; Quality of Life; Rectal Neoplasms | 2004 |
[A case of advanced gastric cancer successfully treated with neoadjuvant chemotherapy of combined weekly paclitaxel and doxifluridine (5'-DFUR)].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Drug Administration Schedule; Floxuridine; Gastrectomy; Humans; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Paclitaxel; Stomach Neoplasms | 2004 |
Therapeutic effects of novel anti-tumor reagent, apoptosis inducing nucleosides from CD57+HLA-DRbright natural suppressor cell line on human gastric carcinoma-bearing SCID mice.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Body Weight; CD57 Antigens; Chromatography, High Pressure Liquid; Floxuridine; HLA-DR Antigens; Humans; Male; Mice; Mice, SCID; Nucleosides; Stomach Neoplasms; T-Lymphocytes, Regulatory; Tumor Cells, Cultured | 2004 |
Rational combinations of trastuzumab with chemotherapeutic drugs used in the treatment of breast cancer.
Topics: Animals; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Cell Line, Tumor; Cell Survival; Cyclophosphamide; Deoxycytidine; Disease Models, Animal; DNA, Neoplasm; Docetaxel; Doxorubicin; Drug Synergism; Enzyme-Linked Immunosorbent Assay; Epirubicin; Female; Floxuridine; Gemcitabine; Gene Expression Regulation, Neoplastic; Guanine Nucleotide Exchange Factors; Humans; Mice; Mice, Nude; Neoplastic Stem Cells; Paclitaxel; Proto-Oncogene Proteins; Receptor, ErbB-2; Taxoids; Transplantation, Heterologous; Trastuzumab; Tumor Stem Cell Assay; Up-Regulation; Vinblastine; Vinorelbine | 2004 |
Doxifluridine-induced neurotoxicity with normal dihydropyrimidine dehydrogenase activity.
Topics: Aged; Antimetabolites, Antineoplastic; Biotransformation; Cerebellar Nuclei; Chemotherapy, Adjuvant; Combined Modality Therapy; Dihydrouracil Dehydrogenase (NADP); Dysarthria; Floxuridine; Gait Disorders, Neurologic; Gastrectomy; Humans; Magnetic Resonance Imaging; Male; Nystagmus, Pathologic; Paresthesia; Stomach Neoplasms; Tremor | 2004 |
[Thymidine phosphorylase expressed in monocyte-macrophages enhanced anticancer effect of 5'-deoxy-5-fluorouridine on colorectal carcinoma cells].
Topics: Adenocarcinoma; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Antimetabolites, Antineoplastic; Cell Line, Tumor; Colorectal Neoplasms; Enzyme-Linked Immunosorbent Assay; Floxuridine; Humans; Immunohistochemistry; Macrophages; Monocytes; Thymidine Phosphorylase; U937 Cells | 2004 |
Prediction of 5'-deoxy-5-fluorouridine sensitivity in colorectal cancer cases by thymidine phosphorylase activity and preliminary identification of susceptibility related genes.
Topics: Aged; Antimetabolites, Antineoplastic; Cell Division; Cell Line, Tumor; Colonic Neoplasms; Colorectal Neoplasms; Female; Floxuridine; Gene Expression Regulation, Neoplastic; Genetic Predisposition to Disease; Humans; Male; Middle Aged; RNA, Messenger; Thymidine Phosphorylase | 2004 |
Bioactivation of capecitabine in human liver: involvement of the cytosolic enzyme on 5'-deoxy-5-fluorocytidine formation.
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cytosol; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; In Vitro Techniques; Microsomes, Liver; Prodrugs; Pyridines; Thymidine Phosphorylase | 2004 |
S-1-induced, prolonged complete regression of lung metastasis from gastric cancer refractory to 5'-DFUR: a case report with pharmacokinetic study.
Topics: Adenocarcinoma, Mucinous; Administration, Oral; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Drug Combinations; Esophagectomy; Female; Floxuridine; Fluorouracil; Gastrectomy; Humans; Lung Neoplasms; Middle Aged; Oxonic Acid; Pyridines; Radiography, Thoracic; Remission Induction; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed | 2004 |
[Enhancement effect of interferon gamma on the sensitivity of RT4 bladder cancer cells to 5'-deoxy-5-fluorouridine,and 5-fluorouracil through up-regulation of PD-ECGF/TP].
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Synergism; Floxuridine; Fluorouracil; Humans; Interferon-gamma; RNA, Messenger; Thymidine Phosphorylase; Up-Regulation; Urinary Bladder Neoplasms | 2004 |
[A case of liver metastasis of colon cancer responding remarkably to 5'-DFUR].
Topics: Adenocarcinoma; Aged; Antimetabolites, Antineoplastic; Colon, Sigmoid; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Humans; Liver Neoplasms; Male; Remission Induction; Sigmoid Neoplasms | 2004 |
[A long-surviving patient with Stage IV breast cancer with no recurrence after combined therapy of medroxy progesterone acetate (MPA) and intra-arterial infusion chemotherapy].
Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Epirubicin; Female; Floxuridine; Humans; Infusions, Intra-Arterial; Lymphatic Metastasis; Mastectomy, Segmental; Medroxyprogesterone Acetate; Neoplasm Staging; Survivors; Tamoxifen | 2004 |
[Combination therapy with Anastrozole and 5'-DFUR as a treatment for metastatic breast cancer].
Topics: Aged; Aged, 80 and over; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Nitriles; Postmenopause; Receptors, Estrogen; Survival Rate; Triazoles | 2004 |
Lack of contribution of dihydrofluorouracil and alpha-fluoro-beta-alanine to the cytotoxicity of 5'-deoxy-5-fluorouridine on human keratinocytes.
Topics: Antineoplastic Agents; beta-Alanine; Cell Line, Tumor; Dihydrouracil Dehydrogenase (NADP); Dose-Response Relationship, Drug; Floxuridine; Fluorouracil; Foot Dermatoses; Hand Dermatoses; Humans; Inhibitory Concentration 50; Keratinocytes; Syndrome; Thymidine Phosphorylase | 2004 |
[A case of disseminated tumor from cecal cancer with survival for over 5 years after twice surgical resection and systemic chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Cecal Neoplasms; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Irinotecan; Leucovorin; Male; Neoplasm Seeding; Peritoneal Neoplasms; Reoperation | 2004 |
[A case of long-term survival after chemo-radiation for postoperative local recurrence of rectal cancer].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Combined Modality Therapy; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Rectal Neoplasms | 2004 |
Comparative antitumor activity of 5-fluorouracil and 5'-deoxy-5-fluorouridine in combination with interferon-alpha in renal cell carcinoma cell lines.
Topics: Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Renal Cell; Drug Screening Assays, Antitumor; Floxuridine; Fluorouracil; Humans; Interferon-alpha; Kidney Neoplasms; Tumor Cells, Cultured | 2004 |
[Successful combination therapy with 5'-DFUR and MPA for breast cancer with spinal and vertebral metastases].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cyclophosphamide; Doxorubicin; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Magnetic Resonance Imaging; Mastectomy; Medroxyprogesterone Acetate; Middle Aged; Remission Induction; Spinal Cord Neoplasms; Spinal Neoplasms | 2004 |
[Docetaxel (TXT), epirubicin (EPI) and doxifluridine (5'-DFUR) combination neoadjuvant chemotherapy for outpatients with locally advanced breast cancer].
Topics: Adenocarcinoma, Scirrhous; Adult; Aged; Ambulatory Care; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Chemotherapy, Adjuvant; Combined Modality Therapy; Cystadenocarcinoma, Serous; Docetaxel; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Humans; Middle Aged; Preoperative Care; Taxoids | 2004 |
[Significance of tissue thymidine phosphorylase and dihydropyrimidine dehydrogenase activities in ovarian cancer].
Topics: 5'-Nucleotidase; Adenocarcinoma, Scirrhous; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Ovarian Neoplasms; Survival Rate | 2004 |
Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells.
Topics: Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Docetaxel; Floxuridine; Gene Expression; Gene Expression Profiling; Humans; Male; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Taxoids | 2005 |
Taxotere-5'-deoxy-5-fluorouridine combination on hormone-refractory human prostate cancer cells.
Topics: Antineoplastic Agents, Phytogenic; Cell Line, Tumor; Docetaxel; Drug Screening Assays, Antitumor; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Floxuridine; Humans; Male; Prostatic Neoplasms; Taxoids; Thymidine Phosphorylase; Thymidylate Synthase | 2005 |
Development of a stereological method to measure levels of fluoropyrimidine metabolizing enzymes in tumor sections using laser scanning cytometry.
Topics: Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Line, Tumor; Cell Proliferation; Dihydrouracil Dehydrogenase (NADP); Esophageal Neoplasms; Floxuridine; Fluorescent Antibody Technique; Fluorescent Dyes; Humans; Laser Scanning Cytometry; Neoplasms; Pyrimidines; Thymidine Phosphorylase | 2005 |
Doxycycline may reduce the incidence of aneurysms in haemodialysis vascular accesses.
Topics: Adult; Aged; Aneurysm; Arteriovenous Shunt, Surgical; Catheters, Indwelling; Female; Floxuridine; Humans; Incidence; Male; Middle Aged; Renal Dialysis | 2005 |
Thymidine phosphorylase expression and efficacy of adjuvant doxifluridine in advanced colorectal cancer patients.
Topics: Administration, Oral; Aged; Antibodies, Monoclonal; Antimetabolites, Antineoplastic; Cell Differentiation; Cell Line, Tumor; Chemotherapy, Adjuvant; Colorectal Neoplasms; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Prognosis; Risk; Thymidine Phosphorylase; Time Factors; Treatment Outcome | 2005 |
[Weekly paclitaxel administration and intraabdominal CBDCA injection possibly beneficial treatment for recurrent breast cancer associated with metastatic ovarian cancer and peritoneal dissemination after operation--a case report].
Topics: Adenocarcinoma, Scirrhous; Anastrozole; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carboplatin; Drug Administration Schedule; Female; Floxuridine; Humans; Hysterotomy; Infusions, Intravenous; Injections, Intraperitoneal; Middle Aged; Nitriles; Ovarian Neoplasms; Paclitaxel; Peritoneal Neoplasms; Triazoles | 2005 |
[Effective reduction of elevated tumor markers by exemestane--a 12-year follow-up of a case of bone metastatic breast cancer].
Topics: Aged; Androstadienes; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Bone Neoplasms; Breast Neoplasms; Carcinoembryonic Antigen; Drug Administration Schedule; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Mucin-1; Radionuclide Imaging | 2005 |
[A case of recurrent breast cancer with multiple lung, adrenal, inferior vena cava tumor thrombus and bone metastases successfully treated with 5'-DFUR and hormonal therapy].
Topics: Adult; Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Papillary; Combined Modality Therapy; Cyclophosphamide; Drug Administration Schedule; Epirubicin; Female; Floxuridine; Follow-Up Studies; Humans; Leuprolide; Lung Neoplasms; Mastectomy, Radical; Neoplastic Cells, Circulating; Tamoxifen; Vena Cava, Inferior | 2005 |
Transfection of thymidine phosphorylase cDNA to human hepatocellular carcinoma cells enhances sensitivity to fluoropyrimidine but augments endothelial cell migration.
Topics: Antigens, Neoplasm; Antimetabolites, Antineoplastic; Carcinoma, Hepatocellular; Cell Movement; Disease-Free Survival; DNA Topoisomerases, Type II; DNA-Binding Proteins; DNA, Complementary; Floxuridine; Humans; Immunohistochemistry; In Situ Hybridization, Fluorescence; Liver Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; Survival Analysis; Thymidine Phosphorylase; Transfection | 2005 |
The multidrug resistance protein 5 (ABCC5) confers resistance to 5-fluorouracil and transports its monophosphorylated metabolites.
Topics: Adenosine Triphosphate; Antimetabolites, Antineoplastic; Apoptosis; Biological Transport; Cells, Cultured; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Kidney; Multidrug Resistance-Associated Proteins; Phosphorylation; Thioguanine; Thymidylate Synthase | 2005 |
[Two cases of advanced breast cancer responding to oral chemoendocrine therapy with 5'-deoxy-5-fluorouridine, medroxyprogesterone acetate and cyclophosphamide (DMpC)].
Topics: Administration, Oral; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Carcinoma, Ductal, Breast; Cyclophosphamide; Drug Administration Schedule; Female; Floxuridine; Humans; Leukopenia; Lymph Nodes; Lymphatic Metastasis; Medroxyprogesterone Acetate; Middle Aged | 2005 |
Effects of oral 5-fluorouracil drugs on hepatic fat content in patients with colon cancer.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Chi-Square Distribution; Colonic Neoplasms; Fatty Liver; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Retrospective Studies; Tegafur; Tomography, X-Ray Computed; Uracil | 2005 |
Correlations between antitumor activities of fluoropyrimidines and DPD activity in lung tumor xenografts.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Humans; Lung Neoplasms; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Orotate Phosphoribosyltransferase; Oxonic Acid; Pyridines; Tegafur; Thymidine Phosphorylase; Treatment Outcome; Uracil; Xenograft Model Antitumor Assays | 2005 |
Enhancement of antitumor activity of 5'-deoxy-5-fluorouridine (Furtulon) by taxane in human gastric cancer xenografts.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bridged-Ring Compounds; Cell Line, Tumor; Floxuridine; Humans; Immunohistochemistry; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Stomach Neoplasms; Taxoids; Thymidine Phosphorylase; Time Factors; Treatment Outcome; Up-Regulation; Xenograft Model Antitumor Assays | 2005 |
Combination of 5-deoxy-5-fluorouridine and tamoxifen show cell-type specific antagonistic and cooperative effects on cytotoxicity in human mammary carcinoma cells.
Topics: Antineoplastic Agents; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Synergism; Flow Cytometry; Floxuridine; Humans; Tamoxifen; Time Factors | 2005 |
5-Fluorouracil concentration in blood, liver and tumor tissues and apoptosis of tumor cells after preoperative oral 5'-deoxy-5-fluorouridine in patients with hepatocellular carcinoma.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Carcinoma, Hepatocellular; Female; Floxuridine; Fluorouracil; Humans; Liver; Liver Neoplasms; Male; Middle Aged; Preoperative Care | 2005 |
[Long-term survival in a case of large bowel cancer--efficacy of CPT-11-based chemotherapy].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Colorectal Neoplasms; Drug Administration Schedule; Female; Floxuridine; Humans; Irinotecan; Lung Neoplasms; Lymphatic Metastasis; Mitomycin; Peritoneal Neoplasms; Survivors | 2005 |
Preferential inhibition of bone metastases by 5'-deoxy-5-fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model.
Topics: Administration, Oral; Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Capecitabine; Cell Line, Tumor; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Luciferases; Mammary Neoplasms, Experimental; Mice; Mice, Inbred BALB C; Time Factors; Transfection; Treatment Outcome | 2005 |
The benefit of post-operative adjuvant chemotherapy using oral fluoropyrimidines in rectal cancer.
Topics: Administration, Oral; Adult; Aged; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Female; Floxuridine; Humans; Male; Middle Aged; Rectal Neoplasms; Retrospective Studies; Survival Rate; Tegafur | 2005 |
[Experience with capecitabine in patients with anthracycline and/or taxane-resistant recurrent breast cancer].
Topics: Administration, Oral; Anthracyclines; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Drug Resistance, Neoplasm; Female; Floxuridine; Fluorouracil; Humans; Middle Aged; Taxoids | 2005 |
The MMP-9 expression determined the efficacy of postoperative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Disease-Free Survival; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Retrospective Studies; Survival Rate; Tegafur; Uracil | 2006 |
[Experience of weekly paclitaxel combined with orally administered doxifluridine therapy for advanced and recurrent gastric cancer-preliminary study].
Topics: Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Feasibility Studies; Female; Floxuridine; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Stomach Neoplasms | 2005 |
Simultaneous determination of capecitabine and its metabolites by HPLC and mass spectrometry for preclinical and clinical studies.
Topics: Animals; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Humans; Liver; Mice; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2005 |
[Prediction and treatment of peritoneal dissemination in gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Humans; Ileus; Lymphatic Metastasis; Male; Middle Aged; Oxonic Acid; Paclitaxel; Peritoneal Cavity; Peritoneal Lavage; Peritoneal Neoplasms; Predictive Value of Tests; Prognosis; Pyridines; Stomach Neoplasms; Survival Rate; Tegafur | 2005 |
[Case report--postoperative continuous intraarterial infusion of small doses of 5-FU successfully controlled residual tumor and liver metastasis of stage IV gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Disease-Free Survival; Doxorubicin; Drug Combinations; Floxuridine; Fluorouracil; Gastrectomy; Humans; Infusions, Intra-Arterial; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Methotrexate; Mitomycin; Neoplasm Staging; Picibanil; Proteoglycans; Stomach Neoplasms; Tegafur; Uracil | 2005 |
[A case of advanced gastric cancer with direct invasion of the transverse colon responding to paclitaxel/5'-DFUR combined therapy].
Topics: Adenocarcinoma, Scirrhous; Antineoplastic Combined Chemotherapy Protocols; Colon, Transverse; Colonic Neoplasms; Drug Administration Schedule; Floxuridine; Humans; Ileus; Male; Middle Aged; Neoplasm Invasiveness; Paclitaxel; Peritoneal Neoplasms; Quality of Life; Stomach Neoplasms | 2005 |
[A case of metastatic colon cancer treated with oxaliplatin combination chemotherapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Male; Organoplatinum Compounds; Oxaliplatin; Quality of Life | 2005 |
[A case of chemoradiation with tissue expander for local reccurence of rectal cancer].
Topics: Adenocarcinoma, Mucinous; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Floxuridine; Humans; Irinotecan; Middle Aged; Neoplasm Recurrence, Local; Quality of Life; Radiotherapy Dosage; Rectal Neoplasms; Tissue Expansion Devices | 2005 |
[Pharmacokinetic comparison of capecitabine and 5'-deoxy-5-fluorouridine (doxifluridine; 5'-DFUR)].
Topics: Antimetabolites, Antineoplastic; Area Under Curve; Breast Neoplasms; Capecitabine; Clinical Trials, Phase II as Topic; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Prodrugs | 2005 |
Upregulation of thymidine phosphorylase in rectal cancer tissues by mitomycin C.
Topics: Adult; Aged; Analysis of Variance; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Disease-Free Survival; Female; Floxuridine; Fluorouracil; Humans; Immunohistochemistry; Male; Middle Aged; Mitomycin; Rectal Neoplasms; Thymidine Phosphorylase; Up-Regulation | 2006 |
Modulation of uridine phosphorylase gene expression by tumor necrosis factor-alpha enhances the antiproliferative activity of the capecitabine intermediate 5'-deoxy-5-fluorouridine in breast cancer cells.
Topics: Animals; Base Sequence; Capecitabine; Deoxycytidine; DNA Primers; Drug Synergism; Electrophoretic Mobility Shift Assay; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Mammary Neoplasms, Experimental; Mice; NF-kappa B; Tumor Necrosis Factor-alpha; Uridine Phosphorylase | 2006 |
Induction of thymidine phosphorylase expression by AZT contributes to enhancement of 5'-DFUR cytotoxicity.
Topics: Antimetabolites; Cell Survival; Drug Synergism; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transfection; U937 Cells; Zidovudine | 2006 |
[A long-term survivor with stage IV gastric cancer due to postoperative weekly paclitaxel and 5'-DFUR combination therapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Signet Ring Cell; Combined Modality Therapy; Drug Administration Schedule; Female; Floxuridine; Gastrectomy; Humans; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Staging; Paclitaxel; Quality of Life; Salvage Therapy; Stomach Neoplasms; Survivors | 2006 |
[Combined chemotherapy with weekly Paclitaxel and doxifluridine for advanced and recurrent gastric cancers].
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Female; Floxuridine; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Retrospective Studies; Stomach Neoplasms; Survival Analysis | 2006 |
[A case of recurrent gastric cancer effectively treated by combination chemotherapy of weekly paclitaxel and 5'- DFUR after showing resistance to weekly paclitaxel].
Topics: Adenocarcinoma; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Combined Modality Therapy; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Gastrectomy; Humans; Lung Neoplasms; Lymph Node Excision; Paclitaxel; Quality of Life; Stomach Neoplasms | 2006 |
The expression of vascular endothelial growth factor determines the efficacy of post-operative adjuvant chemotherapy using oral fluoropyrimidines in stage II or III colorectal cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Colorectal Neoplasms; Combined Modality Therapy; Disease-Free Survival; Female; Floxuridine; Humans; Male; Neoplasm Invasiveness; Neoplasm Recurrence, Local; Neoplasm Staging; Postoperative Period; Retrospective Studies; Survival Rate; Tegafur; Vascular Endothelial Growth Factor A | 2006 |
[A case of gastric cancer with multiple liver metastases resistant to TS-1 responding to chemotherapy with paclitaxel plus doxifluridine].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Drug Administration Schedule; Drug Combinations; Drug Resistance, Neoplasm; Floxuridine; Humans; Irinotecan; Liver Neoplasms; Male; Oxonic Acid; Paclitaxel; Pyridines; Stomach Neoplasms; Tegafur | 2006 |
The role of thymidine phosphorylase and uridine phosphorylase in (fluoro)pyrimidine metabolism in peripheral blood mononuclear cells.
Topics: Cells, Cultured; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Leukocytes, Mononuclear; Pyrimidines; RNA; Substrate Specificity; Thymidine; Thymidine Phosphorylase; Uridine Phosphorylase | 2006 |
Relationship between AUC of 5'-DFUR and toxicity of capecitabine, fluoropyrimidine carbamate analogs, and 5'-DFUR in monkeys, mice, and rats.
Topics: Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capecitabine; Carbamates; Deoxycytidine; Floxuridine; Fluorouracil; Intestines; Macaca fascicularis; Male; Mice; Rats; Rats, Sprague-Dawley | 2006 |
Rapid microwave-assisted fluorination yielding novel 5'-deoxy-5'-fluorouridine derivatives.
Topics: Floxuridine; Fluorine; Microwaves; Molecular Structure; Time Factors | 2006 |
Human equilibrative nucleoside transporter-1 (hENT1) is required for the transcriptomic response of the nucleoside-derived drug 5'-DFUR in breast cancer MCF7 cells.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cell Membrane; Cell Survival; Equilibrative Nucleoside Transporter 1; Female; Floxuridine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Oligonucleotide Array Sequence Analysis; Protein Biosynthesis; Transcription, Genetic | 2006 |
[A case of local recurrence of rectal cancer in long-term responding to combined therapy of low-dose CPT-11 and 5'-DFUR].
Topics: Adenocarcinoma; Administration, Oral; Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Carcinoembryonic Antigen; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Humans; Irinotecan; Male; Neoplasm Recurrence, Local; Rectal Neoplasms; Remission Induction | 2006 |
Irinotecan cytotoxicity does not necessarily depend on the UGT1A1 polymorphism but on fluoropyrimidine: a molecular case report.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colonic Neoplasms; Female; Floxuridine; Fluorouracil; Glucuronosyltransferase; Humans; Irinotecan; Polymorphism, Genetic | 2006 |
[Effectiveness of preoperative chemoradiotherapy for advanced rectal cancer].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Drug Administration Schedule; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Neoplasm Staging; Pelvis; Preoperative Care; Radiotherapy Dosage; Radiotherapy, Adjuvant; Rectal Neoplasms; Rectum; Survival Rate | 2006 |
[A case of advanced gastric cancer--efficacy of combination therapy of doxifluridine and weekly paclitaxel].
Topics: Adenocarcinoma; Aged; Antineoplastic Combined Chemotherapy Protocols; Aorta; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Gastrectomy; Humans; Lymph Nodes; Lymphatic Metastasis; Male; Paclitaxel; Remission Induction; Stomach Neoplasms | 2006 |
[A case of stage IVA intrahepatic biliary tract cancer successfully treated with gemcitabine].
Topics: Administration, Oral; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; CA-19-9 Antigen; Carcinoembryonic Antigen; Deoxycytidine; Drug Administration Routes; Floxuridine; Gemcitabine; Humans; Liver Neoplasms; Male; Middle Aged; Neoplasm Staging; Tomography, X-Ray Computed | 2006 |
Rapid and simultaneous determination of capecitabine and its metabolites in mouse plasma, mouse serum, and in rabbit bile by high-performance liquid chromatography.
Topics: Animals; Bile; Calibration; Capecitabine; Chromatography, High Pressure Liquid; Deoxycytidine; Floxuridine; Fluorouracil; Mice; Plasma; Rabbits; Reproducibility of Results; Serum | 2007 |
Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines.
Topics: Cell Line, Tumor; Colonic Neoplasms; Drug Resistance, Neoplasm; Enzyme Inhibitors; Floxuridine; Humans; Kinetics; Pyrimidines; Substrate Specificity; Thymidine Phosphorylase; Uridine; Uridine Phosphorylase | 2007 |
The Hollow Fibre Assay as a model for in vivo pharmacodynamics of fluoropyrimidines in colon cancer cells.
Topics: Administration, Oral; Animals; Apoptosis; Capecitabine; Cell Cycle; Cell Line, Tumor; Colonic Neoplasms; Deoxycytidine; Drug Combinations; Drug Synergism; Enzyme Inhibitors; Flow Cytometry; Floxuridine; Fluorouracil; Humans; Mice; Mice, Inbred BALB C; Pyrrolidines; Sensitivity and Specificity; Thymidine Phosphorylase; Thymine; Treatment Outcome; Trifluridine; Tumor Cells, Cultured; Uracil; Xenograft Model Antitumor Assays | 2007 |
Unresectable gastric cancer with multiple liver metastases effectively treated with combined paclitaxel and doxifluridine chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Floxuridine; Humans; Liver Neoplasms; Male; Paclitaxel; Stomach Neoplasms; Treatment Outcome | 2006 |
[A treatment for pulmonary metastases from colorectal cancer by pre-operative CPT-11/5'-DFUR combination therapy].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Colorectal Neoplasms; Female; Floxuridine; Humans; Irinotecan; Lung Neoplasms; Middle Aged; Neoadjuvant Therapy; Pneumonectomy | 2006 |
[A case of colon cancer liver metastases treated by combined therapies].
Topics: Antineoplastic Combined Chemotherapy Protocols; Catheter Ablation; Chemotherapy, Adjuvant; Colon, Sigmoid; Combined Modality Therapy; Floxuridine; Fluorouracil; Hepatectomy; Humans; Jaundice, Obstructive; Leucovorin; Liver Neoplasms; Lymph Node Excision; Male; Middle Aged; Sigmoid Neoplasms; Stents; Tegafur | 2006 |
[A case of recurrent gastric cancer with peritoneal dissemination responding to doxifluridine/paclitaxel combination chemotherapy as third-line treatment].
Topics: Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Combined Modality Therapy; Drug Administration Schedule; Floxuridine; Gastrectomy; Humans; Male; Middle Aged; Paclitaxel; Peritoneal Neoplasms; Splenectomy; Stomach Neoplasms | 2007 |
[Combination therapy with bi-weekly docetaxel and 5'-deoxy-5-fluorouridine for advanced gastric cancer].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Docetaxel; Drug Administration Schedule; Floxuridine; Gastrectomy; Humans; Liver Neoplasms; Lymph Node Excision; Lymph Nodes; Lymphatic Metastasis; Male; Middle Aged; Stomach Neoplasms; Taxoids | 2007 |
[An inadvertent contraindicated combined use of newly prescribed TS-1 and unused doxifluridine].
Topics: Aged; Contraindications; Drug Combinations; Floxuridine; Humans; Male; Medication Errors; Oxonic Acid; Rectal Neoplasms; Self Medication; Tegafur | 2007 |
Doxifluridine combined with weekly paclitaxel for second-line treatment in patients with gastric cancer resistant to TS-1.
Topics: Abdominal Neoplasms; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Administration Schedule; Drug Resistance, Neoplasm; Female; Floxuridine; Humans; Japan; Liver Neoplasms; Lung Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Recurrence, Local; Paclitaxel; Pilot Projects; Silicates; Stomach Neoplasms; Survival Analysis; Time Factors; Titanium; Treatment Outcome; Tumor Burden | 2007 |
[Evaluation of combination therapy of high-dose toremifene and oral chemotherapy].
Topics: Administration, Oral; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Capecitabine; Cyclophosphamide; Deoxycytidine; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Liver Neoplasms; Lung Neoplasms; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Neoplasm Recurrence, Local; Oxonic Acid; Quality of Life; Skin Neoplasms; Tegafur; Toremifene | 2007 |
Development and characterization of a model of liver metastasis using human colon cancer HCT-116 cells.
Topics: Adenocarcinoma; Animals; Antimetabolites, Antineoplastic; Antineoplastic Agents, Phytogenic; Camptothecin; Cell Adhesion; Cell Line, Tumor; Collagen Type II; Colonic Neoplasms; Female; Fibronectins; Floxuridine; Fluorouracil; Humans; Irinotecan; Laminin; Liver Neoplasms; Mice; Mice, Inbred C57BL; Mice, Nude; Models, Biological; Neoplasm Metastasis; Paclitaxel | 2007 |
Heterogeneous ribonucleoprotein k and thymidine phosphorylase are independent prognostic and therapeutic markers for nasopharyngeal carcinoma.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Biomarkers, Pharmacological; Biomarkers, Tumor; Carcinoma; Cytoplasm; Drug Resistance, Neoplasm; Female; Floxuridine; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Male; Middle Aged; Nasopharyngeal Neoplasms; Prognosis; Survival Analysis; Thymidine Phosphorylase | 2008 |
Immunochemotherapy with PSK and fluoropyrimidines improves long-term prognosis for curatively resected colorectal cancer.
Topics: Aged; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Colorectal Neoplasms; Combined Modality Therapy; Drug Combinations; Female; Floxuridine; Fluorouracil; Humans; Immunotherapy; Kaplan-Meier Estimate; Male; Middle Aged; Prognosis; Proportional Hazards Models; Proteoglycans; Retrospective Studies; Tegafur; Uracil | 2008 |
Simultaneous determination of doxifluridine and 5-fluorouracil in monkey serum by high performance liquid chromatography with tandem mass spectrometry.
Topics: Administration, Oral; Animals; Antimetabolites, Antineoplastic; Chromatography, High Pressure Liquid; Drug Stability; Floxuridine; Fluorouracil; Linear Models; Macaca fascicularis; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
[Establishment of a 5-DFUR-resistant human hepatocellular carcinoma cell model and preliminary study of the mechanisms of the drug resistance].
Topics: Antimetabolites, Antineoplastic; ATP Binding Cassette Transporter, Subfamily B, Member 1; Carcinoma, Hepatocellular; Cell Line, Tumor; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Floxuridine; Glutathione Transferase; Humans; Liver Neoplasms; Proto-Oncogene Proteins c-bcl-2 | 2008 |
Fluorinase-coupled base swaps: synthesis of [18F]-5'-deoxy-5'-fluorouridines.
Topics: Bacterial Proteins; Floxuridine; Fluorine Radioisotopes; Isotope Labeling; Oxidoreductases | 2008 |
[Doxifluridine, medroxyprogesterone acetate and cyclophosphamide (DMpC) combination therapy is effective against recurrent triple negative breast cancer--a case report].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Middle Aged; Neoplasm Recurrence, Local; Positron-Emission Tomography; Tomography, X-Ray Computed | 2008 |
Ring-opening polymerization of epsilon-caprolactone initiated by the antitumor agent doxifluridine.
Topics: Antineoplastic Agents; Caproates; Floxuridine; Lactones; Magnetic Resonance Spectroscopy; Molecular Structure; Polymers | 2009 |
[A case of complete response for advanced gastric cancer with liver metastasis treated with combination chemotherapy of weekly paclitaxel and doxifluridine].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Biomarkers, Tumor; Floxuridine; Humans; Liver Neoplasms; Male; Neoplasm Staging; Paclitaxel; Remission Induction; Stomach Neoplasms; Tomography, X-Ray Computed; Treatment Outcome | 2009 |
[Complete response obtained with first-line therapy as S-1, followed by second-line 5'-DFUR plus paclitaxel therapy in a patient with multiple liver and lymph node metastases from gastric cancer].
Topics: Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antigen; Drug Combinations; Floxuridine; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Oxonic Acid; Paclitaxel; Remission Induction; Stomach Neoplasms; Tegafur; Tomography, X-Ray Computed | 2009 |
Postoperative chemotherapy after neoadjuvant chemoradiation and surgery for rectal cancer: is it essential for patients with ypT0-2N0?
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Disease-Free Survival; Female; Floxuridine; Fluorouracil; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Neoplasm Recurrence, Local; Rectal Neoplasms; Retrospective Studies; Tegafur; Uracil | 2009 |
Peroxisome proliferator-activated receptor gamma coactivator-1alpha enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
Topics: Antimetabolites, Antineoplastic; Base Sequence; Cell Line, Tumor; Cell Proliferation; DNA Primers; Electrophoretic Mobility Shift Assay; Enzyme Induction; ERRalpha Estrogen-Related Receptor; Floxuridine; Humans; Neoplasms; Polymerase Chain Reaction; Receptors, Estrogen; Transcription Factors; Transcription, Genetic; Uridine Phosphorylase | 2009 |
A new, validated HPLC-MS/MS method for the simultaneous determination of the anti-cancer agent capecitabine and its metabolites: 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, 5-fluorouracil and 5-fluorodihydrouracil, in human plasma.
Topics: 1-Propanol; Acetonitriles; Antimetabolites, Antineoplastic; Capecitabine; Chemical Precipitation; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Stability; Floxuridine; Fluorouracil; Furans; Humans; Linear Models; Pyrimidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Trichloroacetic Acid; Uracil; Vidarabine | 2010 |
Comparison of average, scaled average, and population bioequivalence methods for assessment of highly variable drugs: an experience with doxifluridine in beagle dogs.
Topics: Animals; Dogs; Drug Evaluation, Preclinical; Floxuridine; Models, Statistical; Therapeutic Equivalency | 2010 |
[A long term survivor of advanced gastric cancer treated with multi-drug combination chemotherapy].
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Agents, Phytogenic; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Cisplatin; Floxuridine; Humans; Irinotecan; Male; Paclitaxel; Stomach Neoplasms | 2009 |
Increased anticoagulant activity of warfarin used in combination with doxifluridine.
Topics: Administration, Oral; Aged; Anticoagulants; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dose-Response Relationship, Drug; Female; Floxuridine; Fluorouracil; Humans; International Normalized Ratio; Warfarin | 2010 |
Epstein-Barr virus latent membrane protein 1 induces the chemotherapeutic target, thymidine phosphorylase, via NF-kappaB and p38 MAPK pathways.
Topics: Antimetabolites, Antineoplastic; Carcinoma; Cell Line, Tumor; Floxuridine; Humans; Nasopharyngeal Neoplasms; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Protein Structure, Tertiary; Signal Transduction; Thymidine Phosphorylase; Viral Matrix Proteins | 2010 |
Plasma disposition of capecitabine (CCB) and its metabolites 5'-deoxy-5-fluorocytidine (5'-DFCR) and 5'-deoxy-5-fluorouracil (5'-DFUR) with two different capecitabine/oxaliplatin dosage regimens.
Topics: Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Organoplatinum Compounds; Oxaliplatin | 2010 |
Controlled removal of a nonviral episomal vector from transfected cells.
Topics: Animals; Female; Floxuridine; Gene Expression Regulation; Genetic Therapy; Genetic Vectors; Matrix Attachment Regions; Mice; Mice, Inbred BALB C; Plasmids; Transfection | 2010 |
[Bi-weekly docetaxel and doxifluridine combination therapy in pretreated patients with unresectable and/or advanced gastric cancer].
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Docetaxel; Female; Floxuridine; Humans; Liver Neoplasms; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Staging; Stomach Neoplasms; Survival Rate; Taxoids | 2010 |
The relationship between clinicopathological factors and the reduction of pyrimidine nucleoside phosphorylase activity after preoperative administration of 5'-deoxy-5-fluorouridine.
Topics: Antimetabolites, Antineoplastic; Colorectal Neoplasms; Floxuridine; Humans; Pentosyltransferases; Pyrimidine Phosphorylases | 2010 |
Clinical significance of microsatellite instability for stage II or III colorectal cancer following adjuvant therapy with doxifluridine.
Topics: Adult; Aged; Aged, 80 and over; Chemotherapy, Adjuvant; Cohort Studies; Colorectal Neoplasms; Female; Floxuridine; Humans; Male; Microsatellite Instability; Middle Aged; Neoplasm Staging; Young Adult | 2011 |
Vorinostat synergises with capecitabine through upregulation of thymidine phosphorylase.
Topics: Animals; Antineoplastic Agents; Apoptosis; Capecitabine; Cell Line, Tumor; Cell Proliferation; Deoxycytidine; Drug Synergism; Female; Floxuridine; Fluorouracil; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Hydroxamic Acids; Mice; Mice, Inbred BALB C; Thymidine Phosphorylase; Thymidylate Synthase; Up-Regulation; Vorinostat; Xenograft Model Antitumor Assays | 2010 |
Nearly monodispersed core-shell structural Fe3O4@DFUR-LDH submicro particles for magnetically controlled drug delivery and release.
Topics: Antimetabolites, Antineoplastic; Drug Delivery Systems; Ferrosoferric Oxide; Floxuridine; Hydroxides; Magnetics | 2011 |
Bladder tumor associated with phenacetin abuse: a case report and a review of the literature.
Topics: Aged, 80 and over; Analgesics, Non-Narcotic; Antineoplastic Combined Chemotherapy Protocols; Doxorubicin; Floxuridine; Humans; Male; Phenacetin; Radiography; Substance-Related Disorders; Urinary Bladder Neoplasms | 2007 |
Combination therapy by trastuzumab with 5'-deoxy-5-fluorouridine and cyclophosphamide in patients with metastatic breast cancer.
Topics: Adult; Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antimetabolites, Antineoplastic; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Disease-Free Survival; Female; Floxuridine; Humans; Middle Aged; Neoplasm Metastasis; Receptor, ErbB-2; Trastuzumab | 2009 |
[A case of gastric cancer with lung, Virchow and para-aortic lymph node metastases treated successfully using PTX/5'-DFUR].
Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Combined Modality Therapy; Fatal Outcome; Floxuridine; Gastrectomy; Humans; Lung Neoplasms; Lymph Node Excision; Lymphatic Metastasis; Male; Middle Aged; Paclitaxel; Stomach Neoplasms; Tomography, X-Ray Computed | 2011 |
Metronomic doxifluridine chemotherapy combined with the anti-angiogenic agent TNP-470 inhibits the growth of human uterine carcinosarcoma xenografts.
Topics: Angiogenesis Inhibitors; Animals; Antineoplastic Combined Chemotherapy Protocols; Carcinosarcoma; Cell Line, Tumor; Cyclohexanes; Endothelial Cells; Female; Floxuridine; Humans; Mice; Mice, Inbred BALB C; O-(Chloroacetylcarbamoyl)fumagillol; Sesquiterpenes; Thrombospondin 1; Thymidine Phosphorylase; Uterine Neoplasms; Vascular Endothelial Growth Factor A; Xenograft Model Antitumor Assays | 2011 |
Chemotherapeutic-induced apoptosis: a phenotype for pharmacogenomics studies.
Topics: Antineoplastic Agents; Apoptosis; Biomarkers, Pharmacological; Carboplatin; Caspases; Cell Line, Tumor; Cisplatin; Cytarabine; Floxuridine; Genome-Wide Association Study; Glutamates; Guanine; Humans; Paclitaxel; Pemetrexed; Pharmacogenetics; Phenotype; Quantitative Trait Loci; Twins, Monozygotic | 2011 |
[Improved sensitivity of gastric carcinoma cells to fluorouracil-related drugs by transfection of thymidine phosphorylase gene].
Topics: Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Deoxycytidine; Floxuridine; Fluorouracil; Humans; Plasmids; Recombinant Proteins; RNA, Messenger; Sensitivity and Specificity; Stomach Neoplasms; Thymidine Phosphorylase; Transfection | 2011 |
Second-line chemotherapy with paclitaxel and doxifluridine after failure of S-1 in elderly patients with unresectable advanced or recurrent gastric cancer.
Topics: Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Floxuridine; Humans; Male; Neoplasm Recurrence, Local; Oxonic Acid; Paclitaxel; Retrospective Studies; Stomach Neoplasms; Tegafur | 2011 |
Prognostic significance of miR-181b and miR-21 in gastric cancer patients treated with S-1/Oxaliplatin or Doxifluridine/Oxaliplatin.
Topics: Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Drug Combinations; Female; Floxuridine; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Kaplan-Meier Estimate; Male; MicroRNAs; Middle Aged; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Stomach Neoplasms; Tegafur; Treatment Outcome | 2011 |
NF-kappaB activation within macrophages leads to an anti-tumor phenotype in a mammary tumor lung metastasis model.
Topics: Animals; CD11b Antigen; Chemokine CXCL9; Female; Floxuridine; I-kappa B Kinase; Lung; Lung Neoplasms; Macrophages; Mammary Neoplasms, Experimental; Mice; Mice, Transgenic; NF-kappa B; Phenotype; Polyomavirus; Promoter Regions, Genetic; Reactive Oxygen Species; Receptors, Colony-Stimulating Factor; Signal Transduction; Veins | 2011 |
Inhibition of EGFR phosphorylation in a panel of human breast cancer cells correlates with synergistic interactions between gefitinib and 5'-DFUR, the bioactive metabolite of Xeloda.
Topics: Antineoplastic Agents; Breast Neoplasms; Capecitabine; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cell Survival; Deoxycytidine; Drug Synergism; ErbB Receptors; Female; Floxuridine; Fluorouracil; Gefitinib; Gene Expression Regulation, Enzymologic; Humans; Inhibitory Concentration 50; Methotrexate; Phosphorylation; Protein Processing, Post-Translational; Quinazolines; Thymidine Phosphorylase; Thymidylate Synthase | 2012 |
Phosphorylation of 5'-deoxy-5-fluorouridine with inorganic phosphorylating agents.
Topics: Floxuridine; Imides; Phosphorylation; Polyphosphates; Water | 2011 |
Reliability of tumor primary cultures as a model for drug response prediction: expression profiles comparison of tissues versus primary cultures from colorectal cancer patients.
Topics: Adenocarcinoma; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Camptothecin; Capecitabine; Cisplatin; Colorectal Neoplasms; Deoxycytidine; Down-Regulation; Doxorubicin; Etoposide; Floxuridine; Fluorescent Antibody Technique; Fluorouracil; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Genomic Instability; Humans; Irinotecan; Metaphase; Paclitaxel; Polymerase Chain Reaction; Predictive Value of Tests; Protein Array Analysis; Reproducibility of Results; Tegafur; Tissue Array Analysis; Tumor Cells, Cultured; Up-Regulation; Uracil | 2012 |
Heterogeneous ribonucleoprotein K and thymidine phosphorylase are independent prognostic and therapeutic markers for oral squamous cell carcinoma.
Topics: Antimetabolites, Antineoplastic; Carcinoma, Squamous Cell; CASP8 and FADD-Like Apoptosis Regulating Protein; Female; Floxuridine; Heterogeneous-Nuclear Ribonucleoprotein K; Humans; Male; Middle Aged; Mouth Neoplasms; Prognosis; Retrospective Studies; Thymidine Phosphorylase | 2012 |
Synthesis and discovery of N-carbonylpyrrolidine- or N-sulfonylpyrrolidine-containing uracil derivatives as potent human deoxyuridine triphosphatase inhibitors.
Topics: Antineoplastic Agents; Cell Proliferation; Crystallography, X-Ray; Drug Screening Assays, Antitumor; Drug Synergism; Floxuridine; HeLa Cells; Humans; Models, Molecular; Protein Conformation; Pyrophosphatases; Pyrrolidines; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship; Thymidylate Synthase; Uracil | 2012 |
The effect of chemotherapy or radiotherapy on thymidine phosphorylase and dihydropyrimidine dehydrogenase expression in cancer of the uterine cervix.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Carcinoma, Squamous Cell; Chemoradiotherapy; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Fluorouracil; Humans; Ifosfamide; Middle Aged; Neoadjuvant Therapy; Organoplatinum Compounds; Peplomycin; Thymidine Phosphorylase; Uterine Cervical Neoplasms | 2012 |
[Influence of interferon-α2a on thymidine phosphorylase expression and anticancer activity of 5'-deoxy-fluorouridine in human colon carcinoma cell lines LOVO and SW480].
Topics: Cell Line, Tumor; Colonic Neoplasms; Floxuridine; Humans; Interferon alpha-2; Interferon-alpha; Recombinant Proteins; Thymidine Phosphorylase | 2012 |
[Doxifluridine, medroxyprogesterone acetate and cyclophosphamide(DMpC)combination therapy found effective for case of chest wall recurrent breast cancer with bone and pleural metastases].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Breast Neoplasms; Cyclophosphamide; Female; Floxuridine; Humans; Medroxyprogesterone Acetate; Pleural Neoplasms; Quality of Life; Recurrence; Thoracic Wall | 2012 |
Aquaporin 3 (AQP3) participates in the cytotoxic response to nucleoside-derived drugs.
Topics: Antineoplastic Agents; Apoptosis; Aquaporin 3; Blotting, Western; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Size; Cell Survival; Cyclin-Dependent Kinase Inhibitor p21; Deoxycytidine; Dose-Response Relationship, Drug; fas Receptor; Floxuridine; Fluorouracil; Gemcitabine; Gene Expression Regulation, Neoplastic; HT29 Cells; Humans; MCF-7 Cells; Nucleosides; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Up-Regulation | 2012 |
Predictive markers of capecitabine sensitivity identified from the expression profile of pyrimidine nucleoside-metabolizing enzymes.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Cell Line, Tumor; Cytidine Deaminase; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Mice; Mice, Nude; Neoplasms; Nucleoside-Phosphate Kinase; Orotate Phosphoribosyltransferase; Ribonucleotide Reductases; RNA, Messenger; Thymidine Kinase; Thymidine Phosphorylase; Thymidylate Synthase; Uridine Kinase; Uridine Phosphorylase | 2013 |
[A case report of complete response by weekly paclitaxel and 5'-DFUR combination chemotherapy for recurrenced gastric cancer with peritoneal dissemination].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Floxuridine; Gastrectomy; Humans; Male; Paclitaxel; Peritoneal Neoplasms; Recurrence; Stomach Neoplasms | 2012 |
Validation of a simple assay for the quantification of the capecitabine metabolites 5'-DFCR and 5'-DFUR for drug monitoring in patients receiving outpatient chemotherapy.
Topics: Calibration; Chromatography, High Pressure Liquid; Deoxycytidine; Drug Monitoring; Drug Stability; Floxuridine; Humans; Limit of Detection; Outpatients; Sensitivity and Specificity; Solid Phase Extraction | 2013 |
Pharmacokinetic analysis of doxifluridine and its metabolites, 5-fluorouracil and 5-fluorouridine, after oral administration in beagle dogs.
Topics: Administration, Oral; Algorithms; Animals; Antimetabolites, Antineoplastic; Area Under Curve; Capsules; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Dogs; Floxuridine; Fluorouracil; Indicators and Reagents; Mass Spectrometry; Tandem Mass Spectrometry; Uridine | 2013 |
CD49f(high) cells retain sphere-forming and tumor-initiating activities in human gastric tumors.
Topics: Animals; Antineoplastic Agents; Biomarkers, Tumor; Doxorubicin; Drug Resistance, Neoplasm; Floxuridine; Fluorouracil; Humans; Inhibitory Concentration 50; Integrin alpha6; Mice; Mice, Inbred BALB C; Mice, Inbred NOD; Mice, Nude; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells; Spheroids, Cellular; Stomach Neoplasms; Tumor Cells, Cultured | 2013 |
Protein-bound polysaccharide-K augments the anticancer effect of fluoropyrimidine derivatives possibly by lowering dihydropyrimidine dehydrogenase expression in gastrointestinal cancers.
Topics: Antineoplastic Agents; Cell Proliferation; Colonic Neoplasms; Dihydrouracil Dehydrogenase (NADP); Floxuridine; Fluorouracil; Gastrointestinal Neoplasms; Gene Expression Regulation, Neoplastic; HCT116 Cells; Humans; Leukocytes, Mononuclear; Polysaccharides; Protein Binding; Thymidylate Synthase | 2013 |
Comparative in vitro evaluation of transportability and toxicity of capecitabine and its metabolites in cells derived from normal human kidney and renal cancers.
Topics: Antimetabolites, Antineoplastic; Biological Transport; Biotransformation; Capecitabine; Cell Line, Tumor; Deoxycytidine; Equilibrative Nucleoside Transporter 1; Equilibrative-Nucleoside Transporter 2; Floxuridine; Fluorouracil; Gene Expression Regulation, Neoplastic; Humans; Hydrogen-Ion Concentration; Interferon-alpha; Kidney Tubules, Proximal; Kinetics; Nucleosides; Signal Transduction; Thymidine Phosphorylase | 2013 |
[Enhanced anticancer effects of 5'-DFUR on colorectal cancer cell lines SW480 and LOVO by transfection with thymidine phosphorylase cDNA].
Topics: Cell Line, Tumor; Colonic Neoplasms; Floxuridine; Fluorouracil; Humans; Thymidine Phosphorylase; Transcription, Genetic; Transfection | 2013 |
Impact of co-administered drugs on drug monitoring of capecitabine in patients with advanced colorectal cancer.
Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Administration Schedule; Drug Interactions; Drug Monitoring; Floxuridine; Fluorouracil; Humans; Pantoprazole; Proton Pump Inhibitors | 2014 |
Clinical pharmacokinetics of capecitabine and its metabolites in combination with the monoclonal antibody bevacizumab.
Topics: Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; Colorectal Neoplasms; Deoxycytidine; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged | 2014 |
Ultraviolet and 5'fluorodeoxyuridine induced random mutagenesis in Chlorella vulgaris and its impact on fatty acid profile: a new insight on lipid-metabolizing genes and structural characterization of related proteins.
Topics: Acetyl-CoA Carboxylase; Analysis of Variance; Base Sequence; Biofuels; Chlorella vulgaris; Chromatography, Thin Layer; DNA Primers; Fatty Acid Desaturases; Fatty Acids; Floxuridine; Industrial Microbiology; Lipid Metabolism; Microscopy, Electron, Transmission; Models, Molecular; Molecular Sequence Data; Mutagenesis; Oxazines; Polymerase Chain Reaction; Sequence Analysis, DNA; Ultraviolet Rays | 2015 |
Mitochondrial induced and self-monitored intrinsic apoptosis by antitumor theranostic prodrug: in vivo imaging and precise cancer treatment.
Topics: Animals; Antineoplastic Agents; Apoptosis; Cell Line, Tumor; Floxuridine; Humans; Lung Neoplasms; Mice; Mitochondria; Molecular Targeted Therapy; Optical Imaging; Prodrugs | 2014 |
Can thymidine phosphorylase be a predictive marker for gemcitabine and doxifluridine combination chemotherapy in cholangiocarcinoma?: case series.
Topics: Adult; Bile Duct Neoplasms; Bile Ducts, Intrahepatic; Biomarkers, Tumor; Cholangiocarcinoma; Deoxycytidine; Drug Therapy, Combination; Fatal Outcome; Female; Floxuridine; Follow-Up Studies; Gemcitabine; Humans; Immunohistochemistry; Middle Aged; Thymidine Phosphorylase; Tomography, X-Ray Computed | 2014 |
An in vitro liver model on microfluidic device for analysis of capecitabine metabolite using mass spectrometer as detector.
Topics: Antimetabolites, Antineoplastic; Biosensing Techniques; Capecitabine; Cell Survival; Coculture Techniques; Equipment Design; Floxuridine; Hep G2 Cells; Humans; Lab-On-A-Chip Devices; Liver; MCF-7 Cells; Prodrugs; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization | 2015 |
[Transfection of thymidine phosphorylase cDNA with lentiviral vector enhances the anticancer effect of 5'-deoxy-5-fluorouridine on colorectal cancer cell lines HT29 and LS174T].
Topics: Antineoplastic Agents; Cell Line; Cell Line, Tumor; Colorectal Neoplasms; DNA, Complementary; Floxuridine; Fluorouracil; Genetic Vectors; HT29 Cells; Humans; RNA, Messenger; Thymidine Phosphorylase; Transfection | 2015 |
[A Case of Long-Term Survival in a Patient with Small Intestinal Adenocarcinoma with Peritoneal Dissemination].
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Floxuridine; Humans; Intestinal Obstruction; Jejunal Neoplasms; Male; Middle Aged; Paclitaxel; Peritoneal Neoplasms; Time Factors | 2016 |
The association between the duration of fluoropyrimidine-based adjuvant chemotherapy and survival in stage II or III gastric cancer.
Topics: Adenocarcinoma; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Capecitabine; Chemotherapy, Adjuvant; Cisplatin; Drug Combinations; Female; Floxuridine; Follow-Up Studies; Humans; Lymphatic Metastasis; Male; Middle Aged; Neoplasm Invasiveness; Neoplasm Staging; Organoplatinum Compounds; Oxaliplatin; Oxonic Acid; Prognosis; Retrospective Studies; Stomach Neoplasms; Survival Rate; Tegafur; Time Factors; Uracil | 2016 |
Doxifluridine-conjugated 2-5A analog shows strong RNase L activation ability and tumor suppressive effect.
Topics: Antineoplastic Agents; Carbon-13 Magnetic Resonance Spectroscopy; Endoribonucleases; Enzyme Activation; Female; Floxuridine; HeLa Cells; Humans; Mass Spectrometry; Proton Magnetic Resonance Spectroscopy | 2016 |
Circadian variations in the pharmacokinetics of capecitabine and its metabolites in rats.
Topics: Animals; Antimetabolites, Antineoplastic; Capecitabine; Circadian Rhythm; Deoxycytidine; Floxuridine; Fluorouracil; Male; Prodrugs; Rats, Wistar | 2018 |
Rabeprazole intake does not affect systemic exposure to capecitabine and its metabolites, 5'-deoxy-5-fluorocytidine, 5'-deoxy-5-fluorouridine, and 5-fluorouracil.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Area Under Curve; Capecitabine; Cell Proliferation; Chromatography, High Pressure Liquid; Colorectal Neoplasms; Deoxycytidine; Drug Interactions; Female; Floxuridine; Fluorouracil; Humans; Male; Middle Aged; Prospective Studies; Proton Pump Inhibitors; Rabeprazole | 2019 |
An Organic Afterglow Protheranostic Nanoassembly.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Dimerization; Drug Delivery Systems; Floxuridine; Hydrogen Peroxide; Infrared Rays; Luminescent Agents; Mice; Nanoparticles; Neoplasms; Polyethylene Glycols; Prodrugs; Theranostic Nanomedicine; Tissue Distribution; Tumor Microenvironment; Uridine | 2019 |
Pharmacokinetics of Capecitabine and Four Metabolites in a Heterogeneous Population of Cancer Patients: A Comprehensive Analysis.
Topics: Adult; Aged; Antimetabolites, Antineoplastic; Capecitabine; Deoxycytidine; Dihydrouracil Dehydrogenase (NADP); Female; Floxuridine; Gastrectomy; Humans; Male; Middle Aged; Neoplasms; Pharmacogenomic Variants; Prodrugs | 2019 |
Glycosyl ortho-(1-phenylvinyl)benzoates versatile glycosyl donors for highly efficient synthesis of both O-glycosides and nucleosides.
Topics: Benzoates; Biological Products; Capecitabine; Chemistry Techniques, Synthetic; Chemistry, Pharmaceutical; Floxuridine; Glycosides; Glycosylation; Molecular Structure; Nucleosides | 2020 |
Doxifluridine-based pharmacosomes delivering miR-122 as tumor microenvironments-activated nanoplatforms for synergistic treatment of hepatocellular carcinoma.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Floxuridine; Gene Expression Regulation, Neoplastic; Humans; Hydrogen Peroxide; Liver Neoplasms; MicroRNAs; Tumor Microenvironment | 2021 |
The ALPK1/TIFA/NF-κB axis links a bacterial carcinogen to R-loop-induced replication stress.
Topics: Adaptor Proteins, Signal Transducing; Bacterial Proteins; Cell Line, Tumor; DNA; DNA Damage; DNA Replication; Floxuridine; Glycosyltransferases; Helicobacter Infections; Helicobacter pylori; Host-Pathogen Interactions; Humans; Lipopolysaccharides; Mutation; NF-kappa B; Protein Kinases; Reactive Oxygen Species; Stomach Neoplasms | 2020 |
Construction of synergistic pH/H
Topics: A549 Cells; Dose-Response Relationship, Drug; Drug Carriers; Drug Delivery Systems; Drug Liberation; Floxuridine; HeLa Cells; Humans; Hydrogen Peroxide; Hydrogen-Ion Concentration; Molecular Structure; Neoplasms; Optical Imaging; Prodrugs; Structure-Activity Relationship; Tumor Microenvironment | 2022 |
A novel near-infrared theranostic probe for accurate cancer chemotherapy
Topics: Animals; Antineoplastic Agents; Boronic Acids; Cell Line, Tumor; Coumarins; Floxuridine; Fluorescent Dyes; HEK293 Cells; Humans; Hydrogen Peroxide; Male; Mice, Inbred BALB C; Neoplasms; Optical Imaging; Precision Medicine; Thymidine Phosphorylase | 2021 |