doxepin and diphenhydramine

doxepin has been researched along with diphenhydramine in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19903 (15.00)18.7374
1990's1 (5.00)18.2507
2000's9 (45.00)29.6817
2010's7 (35.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Booth, RG; Brown, RL; Bucholtz, EC; Tropsha, A; Wyrick, SD1
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Johans, C; Kinnunen, PK; Söderlund, T; Suomalainen, P1
Bleich, S; Gulbins, E; Kornhuber, J; Reichel, M; Terfloth, L; Tripal, P; Wiltfang, J1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Greene, SL; Reed, CE; Schroeter, AL1
Bernstein, JE; Soltani, K; Whitney, DH1
Carlson, BB; Salamone, JD; Trevitt, JT1
Duan, X; Funaki, Y; Ishikawa, Y; Itoh, M; Iwata, R; Kato, M; Miyake, M; Tashiro, M; Watanuki, S; Yanai, K1
Eschler, DC; Klein, PA1
Huang, ZL; Li, R; Qu, WM; Takata, Y; Urade, Y; Wang, YQ; Zhang, MQ; Zhang, Z1
Elad, S; Yarom, N1
Curtis, A; Ko, SJ; Le-Rademacher, JG; Leenstra, JL; Loprinzi, CL; Martenson, JA; Miller, RC; Novotny, PJ; Qin, R; Reiter, PL; Rine, G; Singh, AK; Sio, TT; Tan, AD1

Reviews

3 review(s) available for doxepin and diphenhydramine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016
An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus.
    Journal of drugs in dermatology : JDD, 2010, Volume: 9, Issue:8

    Topics: Administration, Cutaneous; Diphenhydramine; Doxepin; Evidence-Based Medicine; Histamine Antagonists; Humans; Nonprescription Drugs; Pruritus; Randomized Controlled Trials as Topic

2010

Trials

4 trial(s) available for doxepin and diphenhydramine

ArticleYear
Double-blind crossover study comparing doxepin with diphenhydramine for the treatment of chronic urticaria.
    Journal of the American Academy of Dermatology, 1985, Volume: 12, Issue:4

    Topics: Adolescent; Adult; Aged; Antibodies, Antinuclear; Autoantibodies; Blood Sedimentation; Child; Chronic Disease; Clinical Trials as Topic; Complement System Proteins; Diphenhydramine; Double-Blind Method; Doxepin; Female; Humans; Male; Middle Aged; Thyroid Function Tests; Thyroid Gland; Urticaria

1985
Inhibition of histamine-induced pruritus by topical tricyclic antidepressants.
    Journal of the American Academy of Dermatology, 1981, Volume: 5, Issue:5

    Topics: Administration, Topical; Amitriptyline; Antidepressive Agents, Tricyclic; Diphenhydramine; Double-Blind Method; Doxepin; Humans; Pruritus

1981
Brain histamine H1 receptor occupancy of orally administered antihistamines, bepotastine and diphenhydramine, measured by PET with 11C-doxepin.
    British journal of clinical pharmacology, 2008, Volume: 65, Issue:6

    Topics: Administration, Oral; Adult; Brain; Carbon Radioisotopes; Diphenhydramine; Doxepin; Histamine H1 Antagonists; Histamine H1 Antagonists, Non-Sedating; Humans; Male; Piperidines; Positron-Emission Tomography; Pyridines; Receptors, Histamine H1; Sleep Stages

2008
Effect of Doxepin Mouthwash or Diphenhydramine-Lidocaine-Antacid Mouthwash vs Placebo on Radiotherapy-Related Oral Mucositis Pain: The Alliance A221304 Randomized Clinical Trial.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Administration, Topical; Adult; Aged; Aged, 80 and over; Antacids; Diphenhydramine; Double-Blind Method; Doxepin; Fatigue; Female; Head and Neck Neoplasms; Humans; Lidocaine; Linear Models; Male; Middle Aged; Mouthwashes; Pain; Radiation Injuries; Stomatitis

2019

Other Studies

13 other study(ies) available for doxepin and diphenhydramine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Synthesis, evaluation, and comparative molecular field analysis of 1-phenyl-3-amino-1,2,3,4-tetrahydronaphthalenes as ligands for histamine H(1) receptors.
    Journal of medicinal chemistry, 1999, Aug-12, Volume: 42, Issue:16

    Topics: Animals; Binding Sites; Binding, Competitive; Brain; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ligands; Models, Molecular; Pyrilamine; Radioligand Assay; Structure-Activity Relationship; Tetrahydronaphthalenes

1999
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Surface activity profiling of drugs applied to the prediction of blood-brain barrier permeability.
    Journal of medicinal chemistry, 2004, Mar-25, Volume: 47, Issue:7

    Topics: Blood-Brain Barrier; Lipid Bilayers; Micelles; Permeability; Pharmaceutical Preparations; Structure-Activity Relationship; Surface Properties

2004
Identification of new functional inhibitors of acid sphingomyelinase using a structure-property-activity relation model.
    Journal of medicinal chemistry, 2008, Jan-24, Volume: 51, Issue:2

    Topics: Algorithms; Animals; Cell Line; Cell Line, Tumor; Chemical Phenomena; Chemistry, Physical; Enzyme Inhibitors; Humans; Hydrogen-Ion Concentration; Molecular Conformation; Quantitative Structure-Activity Relationship; Rats; Sphingomyelin Phosphodiesterase

2008
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
Effects of H1 antagonists on cholinomimetic-induced tremulous jaw movements: studies of diphenhydramine, doxepin, and mepyramine.
    Pharmacology, biochemistry, and behavior, 2000, Volume: 65, Issue:4

    Topics: Animals; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Benzodiazepines; Cholinergic Agents; Clozapine; Diphenhydramine; Dose-Response Relationship, Drug; Doxepin; Histamine H1 Antagonists; Jaw; Male; Movement; Olanzapine; Pirenzepine; Pyrilamine; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Receptors, Muscarinic; Tacrine; Tremor

2000
Doxepin and diphenhydramine increased non-rapid eye movement sleep through blockade of histamine H1 receptors.
    Pharmacology, biochemistry, and behavior, 2015, Volume: 129

    Topics: Animals; Diphenhydramine; Doxepin; Electroencephalography; Electromyography; Eye Movements; Histamine H1 Antagonists; Male; Mice; Mice, Knockout; Polysomnography; Sleep

2015
The Search for an Effective Therapy and Pain Relief for Oral Mucositis.
    JAMA, 2019, 04-16, Volume: 321, Issue:15

    Topics: Antacids; Diphenhydramine; Doxepin; Humans; Lidocaine; Mouthwashes; Pain; Stomatitis

2019