doxepin and desmethyldoxepin

doxepin has been researched along with desmethyldoxepin in 46 studies

Research

Studies (46)

Timeframe	Studies, this research(%)	All Research%
pre-1990	22 (47.83)	18.7374
1990's	10 (21.74)	18.2507
2000's	10 (21.74)	29.6817
2010's	2 (4.35)	24.3611
2020's	2 (4.35)	2.80

Authors

Authors	Studies
Cooper, JK; Gurnsey, T; Hawes, EM; Hubbard, JW; Korchinski, ED; McKay, G; Midha, KK; Schwede, R	1
Bakish, D; Hrdina, PD; Lapierre, YD; Swenson, S	1
Alertsen, AR; Matheson, I; Pande, H	1
Dilger, C; Jaeger, H; Salama, Z	1
Brown, MA; Haight, KR; Old, L; Remillard, AJ; Sutherland, DL	1
Emm, T; Lesko, LJ; Perkal, MB	1
Amsel, LP; Hinsvark, ON; Rotenberg, KS; Wecker, MT; Woodworth, JR	1
Abernethy, DR; Todd, EL	1
Iisalo, E; Scheinin, M; Virtanen, R	2
Brown, MA; Haight, KR; McKay, G	1
Booth, J; Hackett, LP; Ilett, KF; Kemp, J	1
Cork, RC; Crago, BR; Davis, TP; Hameroff, SR; Neuman, C; Scherer, K; Womble, JR	1
Fann, WE; Faulkner, RD; Lee, CS; Lewis, WA; Pitts, WM	1
Faulkner, RD; Lee, C	1
Faulkner, RD; Lee, CS; Senekjian, HO	1
Brennan, FJ	1
Davis, TP; Hameroff, SR; Veggeberg, SK; Watts, KL	1
Bianchi, GN; Burrows, GD; Maguire, KP; Norman, TR; Wurm, JM	1
Embil, K; Torosian, G	1
Iisalo, E; Irjala, K; Virtanen, R	1
Bogaert, MG; Deberdt, R; Rosseel, MT; Vranckx, C	1
Kabra, PM; Mar, NA; Marton, LJ	1
Iisalo, E; Mattila, V; Salonen, JS; Scheinin, M; Virtanen, R	1
Adamczyk, M; Fishpaugh, JR; Harrington, C	1
Hubbard, JW; McKay, G; Midha, KK; Yan, J	1
Hubbard, JW; McKay, G; Midha, KK; Yan, JH	1
Hubbard, JW; Midha, KK; Rawson, MJ	2
Moore, CM; Negrusz, A; Perry, JL	1
Frey, OR; Scheidt, P; von Brenndorff, AI	1
Cohen, L; Drake, LA; Flood, JG; Gillies, R; Phillips, SB; Riordan, AT; Stiller, MJ	1
Ahokas, JT; Ching, MS; Ghabrial, H; Haritos, VS	2
Badenhorst, D; de Jager, AD; Hundt, AF; Hundt, HK; Scanes, T; Sutherland, FC; Swart, KJ	1
Hagedorn, HW; Meiser, H; Schulz, R; Zankl, H	1
Gleiter, CH; Meineke, I; Meyer-Barner, M; Schreeb, KH	1
Friedberg, T; Härtter, S; Hiemke, C; Tybring, G; Weigmann, H	1
Albert, KS; Eradiri, O; Lai, JC; Sista, S	1
Koski, A; Ojanperä, I; Sajantila, A; Sistonen, J; Vuori, E	1
Dettling, A; Gronewold, A; Haffner, HT; Skopp, G	1
Barclay, ML; Begg, EJ; Moore, GA; Zhang, M	1
Fassbender, K; Maurer, HH; Remane, D; Schomburg, R; Spiegel, J	1
Deckert, J; Hommers, LG; Menke, A; Samanski, L; Scherf-Clavel, M; Unterecker, S	1
Deckert, J; Hommers, L; Menke, A; Scherf-Clavel, M; Unterecker, S; Zebner, J	1
Aleksanyan, A; Armoudjian, Y; Gevorgyan, A; Harutyunyan, A; Margaryan, T; Mikayelyan, A; Sargsyan, M; Zakaryan, H	1

Reviews

2 review(s) available for doxepin and desmethyldoxepin

Article	Year
Bioequivalence: issues and options. Journal of pharmacokinetics and biopharmaceutics, 1997, Volume: 25, Issue:6 Topics: Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents, Tricyclic; Doxepin; Humans; Ketoprofen; Nortriptyline; Stereoisomerism; Therapeutic Equivalency	1997
The role of metabolites in bioequivalence. Pharmaceutical research, 2004, Volume: 21, Issue:8 Topics: Area Under Curve; Biotransformation; Clinical Trials as Topic; Doxepin; Guidelines as Topic; Humans; Liver; Nortriptyline; Pharmaceutical Preparations; Pharmacokinetics; Therapeutic Equivalency; United States; United States Food and Drug Administration	2004

Trials

6 trial(s) available for doxepin and desmethyldoxepin

Article	Year
Doxepin-cimetidine interaction: increased doxepin bioavailability during cimetidine treatment. Journal of clinical psychopharmacology, 1986, Volume: 6, Issue:1 Topics: Absorption; Adult; Biological Availability; Cimetidine; Doxepin; Drug Interactions; Female; Humans; Male; Random Allocation; Time Factors	1986
Doxepin effects on chronic pain, depression and plasma opioids. The Journal of clinical psychiatry, 1982, Volume: 43, Issue:8 Pt 2 Topics: Adult; Aged; beta-Endorphin; Chronic Disease; Depression; Double-Blind Method; Doxepin; Endorphins; Enkephalins; Female; Humans; Male; Middle Aged; Pain; Placebos; Random Allocation; Sensory Thresholds; Sleep	1982
Doxepin plasma levels and anxiolytic response. International pharmacopsychiatry, 1980, Volume: 15, Issue:4 Topics: Adult; Anxiety Disorders; Clinical Trials as Topic; Doxepin; Female; Humans; Male; Middle Aged; Time Factors	1980
Stereoselective in vivo and in vitro studies on the metabolism of doxepin and N-desmethyldoxepin. Xenobiotica; the fate of foreign compounds in biological systems, 1997, Volume: 27, Issue:12 Topics: Adult; Animals; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Digestive System; Dogs; Doxepin; Guinea Pigs; Half-Life; Humans; Indicators and Reagents; Male; Mass Spectrometry; Rabbits; Rats; Rats, Inbred Lew; Stereoisomerism; Subcellular Fractions; Xenobiotics	1997
Pharmacokinetics of doxepin in subjects with pruritic atopic dermatitis. Journal of the American Academy of Dermatology, 1999, Volume: 41, Issue:2 Pt 1 Topics: Administration, Topical; Adult; Anti-Inflammatory Agents; Antipruritics; Dermatitis, Atopic; Double-Blind Method; Doxepin; Drug Combinations; Female; Humans; Male; Ointments; Triamcinolone Acetonide	1999
Pharmacokinetics of a novel diltiazem HCl extended-release tablet formulation for evening administration. Journal of clinical pharmacology, 2003, Volume: 43, Issue:10 Topics: Adult; Biological Availability; Chronotherapy; Circadian Rhythm; Cross-Over Studies; Delayed-Action Preparations; Diltiazem; Doxepin; Drug Administration Schedule; Female; Humans; Male; Middle Aged; Pharmacokinetics; Tablets	2003

Other Studies

38 other study(ies) available for doxepin and desmethyldoxepin

Article	Year
Stereoselective pharmacokinetics of doxepin isomers. European journal of clinical pharmacology, 1992, Volume: 42, Issue:5 Topics: Adolescent; Adult; Antidepressive Agents, Tricyclic; Doxepin; Humans; Male; Middle Aged; Stereoisomerism; Time Factors	1992
Cis- and trans-isomers of doxepin and desmethyldoxepin in the plasma of depressed patients treated with doxepin. Therapeutic drug monitoring, 1990, Volume: 12, Issue:2 Topics: Chromatography, Gas; Depressive Disorder; Doxepin; Humans; Stereoisomerism	1990
Respiratory depression caused by N-desmethyldoxepin in breast milk. Lancet (London, England), 1985, Nov-16, Volume: 2, Issue:8464 Topics: Adult; Doxepin; Female; Humans; Infant, Newborn; Milk, Human; Respiration Disorders	1985
High-performance liquid chromatographic determination of trans-doxepin and desmethyldoxepin. Arzneimittel-Forschung, 1988, Volume: 38, Issue:10 Topics: Antidepressive Agents, Tricyclic; Calibration; Chemical Phenomena; Chemistry; Chromatography, High Pressure Liquid; Doxepin; Humans; Isomerism; Perazine; Predictive Value of Tests; Quality Control; Reference Standards	1988
The influence of cimetidine versus ranitidine on doxepin pharmacokinetics. European journal of clinical pharmacology, 1987, Volume: 32, Issue:2 Topics: Adolescent; Adult; Cimetidine; Doxepin; Drug Interactions; Half-Life; Humans; Kinetics; Male; Ranitidine	1987
Simultaneous determination of doxepin and nordoxepin in serum using high-performance liquid chromatography. Journal of chromatography, 1987, Aug-07, Volume: 419 Topics: Chromatography, High Pressure Liquid; Doxepin; Humans; Indicators and Reagents	1987
Pharmacokinetic evaluation of two doxepin products. Clinical therapeutics, 1986, Volume: 8, Issue:3 Topics: Antidepressive Agents, Tricyclic; Biological Availability; Doxepin; Humans; Kinetics; Time Factors	1986
Effect of single and repeated doses of activated charcoal on the pharmacokinetics of doxepin. International journal of clinical pharmacology, therapy, and toxicology, 1985, Volume: 23, Issue:1 Topics: Adult; Charcoal; Doxepin; Female; Half-Life; Humans; Intestinal Absorption; Kinetics; Male	1985
Cimetidine-doxepin interaction. Journal of clinical psychopharmacology, 1985, Volume: 5, Issue:4 Topics: Cimetidine; Doxepin; Drug Interactions; Humans; Male; Middle Aged; Ranitidine; Time Factors	1985
Excretion of doxepin and N-desmethyldoxepin in human milk. British journal of clinical pharmacology, 1985, Volume: 20, Issue:5 Topics: Adult; Breast Feeding; Depressive Disorder; Doxepin; Female; Humans; Infant; Milk, Human	1985
Multiple-dose doxepin kinetics in depressed patients. Clinical pharmacology and therapeutics, 1983, Volume: 34, Issue:4 Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Doxepin; Humans; Kinetics; Male; Middle Aged; Time Factors	1983
Comparative assays for doxepin and desmethyldoxepin using high-performance liquid chromatography and high-performance thin-layer chromatography. Journal of pharmaceutical sciences, 1983, Volume: 72, Issue:10 Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dogs; Doxepin; Humans; Time Factors	1983
Hemodialysis of doxepin and desmethyldoxepin in uremic patients. Artificial organs, 1984, Volume: 8, Issue:2 Topics: Adult; Aged; Depression; Doxepin; Half-Life; Humans; Middle Aged; Renal Dialysis; Uremia	1984
Electrophysiological effects of desmethylimipramine and desmethyldoxepin on canine cardiac Purkinje fibers. Toxicology and applied pharmacology, 1984, Jun-30, Volume: 74, Issue:2 Topics: Action Potentials; Animals; Desipramine; Dogs; Doxepin; Female; Heart Conduction System; In Vitro Techniques; Male; Membrane Potentials; Purkinje Fibers	1984
Sensitive and quantitative determination of plasma doxepin and desmethyldoxepin in chronic pain patients by gas chromatography and mass spectrometry. Journal of chromatography, 1983, Apr-08, Volume: 273, Issue:2 Topics: Chronic Disease; Double-Blind Method; Doxepin; Drug Evaluation; Gas Chromatography-Mass Spectrometry; Humans; Pain; Patient Compliance	1983
Solubility and ionization characteristics of doxepin and desmethyldoxepin. Journal of pharmaceutical sciences, 1982, Volume: 71, Issue:2 Topics: Doxepin; Hydrogen-Ion Concentration; Solubility; Thermodynamics	1982
Protein binding of doxepin and desmethyldoxepin. Acta pharmacologica et toxicologica, 1982, Volume: 51, Issue:2 Topics: Anticoagulants; Blood Proteins; Doxepin; Humans; Protein Binding	1982
Plasma levels of the cis- and trans-isomers of doxepin and desmethyldoxepin after administration of doxepin to patients. Arzneimittel-Forschung, 1981, Volume: 31, Issue:1 Topics: Doxepin; Female; Humans; Kinetics; Male; Stereoisomerism	1981
Simultaneous liquid chromatographic analysis of amitriptyline, nortriptyline, imipramine, desipramine, doxepin, and nordoxepin. Clinica chimica acta; international journal of clinical chemistry, 1981, Apr-09, Volume: 111, Issue:2-3 Topics: Amitriptyline; Antidepressive Agents, Tricyclic; Chromatography, Liquid; Desipramine; Doxepin; Humans; Imipramine; Nortriptyline	1981
Single dose pharmacokinetics of doxepin in healthy volunteers. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:5 Topics: Administration, Oral; Adult; Doxepin; Erythrocytes; Female; Half-Life; Humans; Kinetics; Male; Radioimmunoassay	1980
Radioimmunoassay for doxepin and desmethyldoxepin. Acta pharmacologica et toxicologica, 1980, Volume: 47, Issue:4 Topics: Antibody Specificity; Chromatography, High Pressure Liquid; Doxepin; Humans; Mental Disorders; Radioimmunoassay; Time Factors	1980
Quantitative determination of E- and Z-doxepin and E- and Z-desmethyldoxepin by high-performance liquid chromatography. Therapeutic drug monitoring, 1995, Volume: 17, Issue:4 Topics: Antidepressive Agents, Tricyclic; Calibration; Chromatography, High Pressure Liquid; Doxepin; Drug Monitoring; Humans	1995
Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography. Journal of chromatography. B, Biomedical sciences and applications, 1997, Mar-28, Volume: 691, Issue:1 Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Doxepin; Humans; Kinetics; Linear Models; Quality Control; Sensitivity and Specificity; Stereoisomerism	1997
Detection of doxepin and its major metabolite desmethyldoxepin in hair following drug therapy. Journal of analytical toxicology, 1998, Volume: 22, Issue:6 Topics: Adult; Antidepressive Agents, Tricyclic; Depression; Doxepin; Female; Gas Chromatography-Mass Spectrometry; Hair; Humans; Reproducibility of Results; Substance Abuse Detection	1998
Adverse effects in a newborn infant breast-fed by a mother treated with doxepin. The Annals of pharmacotherapy, 1999, Volume: 33, Issue:6 Topics: Adult; Antidepressive Agents, Tricyclic; Breast Feeding; Doxepin; Female; Humans; Infant, Newborn; Milk, Human	1999
Stereoselective measurement of E- and Z-doxepin and its N-desmethyl and hydroxylated metabolites by gas chromatography-mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications, 1999, Dec-24, Volume: 736, Issue:1-2 Topics: Antidepressive Agents, Tricyclic; Calibration; Doxepin; Gas Chromatography-Mass Spectrometry; Humans; Hydrogen-Ion Concentration; Hydroxylation; Microsomes, Liver; Nortriptyline; Sensitivity and Specificity; Stereoisomerism	1999
Determination of doxepin and desmethyldoxepin in human plasma using liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Biomedical sciences and applications, 2000, May-26, Volume: 742, Issue:1 Topics: Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Doxepin; Humans; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization	2000
Role of cytochrome P450 2D6 (CYP2D6) in the stereospecific metabolism of E- and Z-doxepin. Pharmacogenetics, 2000, Volume: 10, Issue:7 Topics: Cytochrome P-450 CYP2D6; Doxepin; Humans; Hydroxylation; Methylation; Microsomes, Liver; Quinidine; Recombinant Proteins	2000
The isomeric metabolites of doxepin in equine serum and urine. Journal of pharmaceutical and biomedical analysis, 2002, Jun-20, Volume: 29, Issue:1-2 Topics: Animals; Antidepressive Agents, Tricyclic; Chromatography, Gas; Doping in Sports; Doxepin; Female; Horses; Mass Spectrometry; Stereoisomerism	2002
Pharmacokinetics of doxepin and desmethyldoxepin: an evaluation with the population approach. European journal of clinical pharmacology, 2002, Volume: 58, Issue:4 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; Doxepin; Female; Humans; Injections, Intravenous; Male; Middle Aged; Models, Biological	2002
The N-demethylation of the doxepin isomers is mainly catalyzed by the polymorphic CYP2C19. Pharmaceutical research, 2002, Volume: 19, Issue:7 Topics: Aryl Hydrocarbon Hydroxylases; Catalysis; Cytochrome P-450 CYP2C19; Doxepin; Humans; Isoenzymes; Isothiocyanates; Microsomes, Liver; Mixed Function Oxygenases; Tranylcypromine	2002
A fatal doxepin poisoning associated with a defective CYP2D6 genotype. The American journal of forensic medicine and pathology, 2007, Volume: 28, Issue:3 Topics: Adult; Antidepressive Agents, Tricyclic; Cytochrome P-450 CYP2D6; Doxepin; Forensic Toxicology; Genotype; Humans; Male	2007
Doxepin and nordoxepin concentrations in body fluids and tissues in doxepin associated deaths. Forensic science international, 2009, Sep-10, Volume: 190, Issue:1-3 Topics: Adult; Antidepressive Agents, Tricyclic; Bile; Brain Chemistry; Chromatography, Liquid; Doxepin; Female; Forensic Toxicology; Gastrointestinal Contents; Humans; Kidney; Liver; Lung; Male; Mass Spectrometry; Middle Aged; Muscle, Skeletal; Substance-Related Disorders	2009
Determination of perhexiline and its metabolite hydroxyperhexiline in human plasma by liquid chromatography/tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Oct-01, Volume: 877, Issue:27 Topics: Chromatography, Liquid; Doxepin; Humans; Linear Models; Perhexiline; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2009
Doxepin concentrations in plasma and cerebrospinal fluid. Journal of neural transmission (Vienna, Austria : 1996), 2011, Volume: 118, Issue:4 Topics: Adult; Aged; Antidepressive Agents, Tricyclic; Depressive Disorder; Doxepin; Female; Humans; Male; Middle Aged; Young Adult	2011
Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2. International clinical psychopharmacology, 2019, Volume: 34, Issue:2 Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents; Antipsychotic Agents; Clozapine; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A; Desvenlafaxine Succinate; Doxepin; Drug Monitoring; Female; Glucuronosyltransferase; Humans; Male; Middle Aged; Mirtazapine; Nortriptyline; Paliperidone Palmitate; Quetiapine Fumarate; Retrospective Studies; Risperidone; Smoking; Venlafaxine Hydrochloride	2019
Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients. European journal of clinical pharmacology, 2020, Volume: 76, Issue:1 Topics: Adult; Aged; Aged, 80 and over; Amitriptyline; Antidepressive Agents, Tricyclic; Atrioventricular Block; Bundle-Branch Block; Doxepin; Electrocardiography; Female; Heart; Heart Function Tests; Humans; Male; Middle Aged; Nortriptyline; Retrospective Studies; Risk Factors	2020
High-throughput protein precipitation method with 96-well plate for determination of doxepin and nordoxepin in human plasma using LC-MS/MS. Biomedical chromatography : BMC, 2020, Volume: 34, Issue:8 Topics: Chemical Precipitation; Chromatography, Liquid; Doxepin; Drug Stability; High-Throughput Screening Assays; Humans; Linear Models; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry	2020