doxepin and chlorpheniramine

doxepin has been researched along with chlorpheniramine in 20 studies

Research

Studies (20)

TimeframeStudies, this research(%)All Research%
pre-19906 (30.00)18.7374
1990's3 (15.00)18.2507
2000's6 (30.00)29.6817
2010's4 (20.00)24.3611
2020's1 (5.00)2.80

Authors

AuthorsStudies
Creveling, CR; Daly, JW; Lewandowski, GA; McNeal, ET1
Andrews, PR; Craik, DJ; Martin, JL1
Chiang, GH; Unger, SH1
Strassburg, CP; Tukey, RH1
Topliss, JG; Yoshida, F1
Lombardo, F; Obach, RS; Waters, NJ1
Ahman, M; Holmén, AG; Wan, H1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV1
Chen, L; He, Z; Li, H; Liu, J; Liu, X; Sui, X; Sun, J; Wang, Y; Zhang, W1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A1
Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ1
Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K1
Hatazawa, J; Ido, T; Ishiwata, K; Itoh, M; Iwata, R; Meguro, K; Takahashi, T; Watanabe, T; Yanai, K; Yokoyama, H1
Barr, RJ; Drayton, G; Goldsobel, AB; Indianer, L; Katz, RM; Peter, JB; Rachelefsky, GS; Rohr, AS; Siegel, SC; Spector, SL1
Lassen, JB1
Sullivan, TJ1
Ido, T; Ito, K; Itoh, M; Iwata, R; Ryu, JH; Sawai, Y; Watanabe, T; Yanai, K1
Itoh, M; Okamura, N; Watanabe, T; Yanai, K1
Baek, SY; Kim, HI; Kim, JH; Kim, YK; Shin, DW; Woo, IS1

Reviews

2 review(s) available for doxepin and chlorpheniramine

ArticleYear
Human UDP-glucuronosyltransferases: metabolism, expression, and disease.
    Annual review of pharmacology and toxicology, 2000, Volume: 40

    Topics: Autoimmunity; Chromosome Mapping; Glucuronides; Glucuronosyltransferase; Humans; Hyperbilirubinemia; Neoplasms; Steroids; Terminology as Topic

2000
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
    Drug discovery today, 2016, Volume: 21, Issue:4

    Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk

2016

Trials

2 trial(s) available for doxepin and chlorpheniramine

ArticleYear
Efficacy of doxepin in the treatment of chronic idiopathic urticaria.
    The Journal of allergy and clinical immunology, 1986, Volume: 78, Issue:5 Pt 1

    Topics: Chlorpheniramine; Codeine; Doxepin; Histamine; Humans; Skin; Skin Tests; Urticaria

1986
Pharmacologic modulation of the whealing response to histamine in human skin: identification of doxepin as a potent in vivo inhibitor.
    The Journal of allergy and clinical immunology, 1982, Volume: 69, Issue:3

    Topics: Adult; Antidepressive Agents, Tricyclic; Chlorpheniramine; Dose-Response Relationship, Immunologic; Double-Blind Method; Doxepin; Histamine; Histamine H1 Antagonists; Humans; Placebos; Skin Tests

1982

Other Studies

16 other study(ies) available for doxepin and chlorpheniramine

ArticleYear
[3H]Batrachotoxinin A 20 alpha-benzoate binding to voltage-sensitive sodium channels: a rapid and quantitative assay for local anesthetic activity in a variety of drugs.
    Journal of medicinal chemistry, 1985, Volume: 28, Issue:3

    Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Anesthetics, Local; Animals; Batrachotoxins; Calcium Channel Blockers; Cyclic AMP; Guinea Pigs; Histamine H1 Antagonists; In Vitro Techniques; Ion Channels; Neurotoxins; Sodium; Tranquilizing Agents; Tritium

1985
Functional group contributions to drug-receptor interactions.
    Journal of medicinal chemistry, 1984, Volume: 27, Issue:12

    Topics: Animals; Calorimetry; Kinetics; Models, Biological; Protein Binding; Receptors, Cell Surface; Receptors, Drug; Structure-Activity Relationship

1984
Octanol-physiological buffer distribution coefficients of lipophilic amines by reversed-phase high-performance liquid chromatography and their correlation with biological activity.
    Journal of medicinal chemistry, 1981, Volume: 24, Issue:3

    Topics: Amines; Animals; Buffers; Chromatography, High Pressure Liquid; Histamine Release; Lipid Metabolism; Octanols; Protein Binding; Rats; Serum Albumin, Bovine; Sodium-Potassium-Exchanging ATPase; Solubility; Structure-Activity Relationship

1981
QSAR model for drug human oral bioavailability.
    Journal of medicinal chemistry, 2000, Jun-29, Volume: 43, Issue:13

    Topics: Administration, Oral; Biological Availability; Humans; Models, Biological; Models, Molecular; Pharmaceutical Preparations; Pharmacokinetics; Structure-Activity Relationship

2000
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
    Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7

    Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding

2008
Relationship between brain tissue partitioning and microemulsion retention factors of CNS drugs.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Brain; Central Nervous System; Chromatography, Liquid; Emulsions; Mass Spectrometry

2009
Physicochemical determinants of human renal clearance.
    Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15

    Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight

2009
Prediction of volume of distribution values in human using immobilized artificial membrane partitioning coefficients, the fraction of compound ionized and plasma protein binding data.
    European journal of medicinal chemistry, 2009, Volume: 44, Issue:11

    Topics: Blood Proteins; Chemistry, Physical; Computer Simulation; Humans; Membranes, Artificial; Models, Biological; Pharmaceutical Preparations; Protein Binding; Tissue Distribution

2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
    Chemical research in toxicology, 2010, Volume: 23, Issue:1

    Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship

2010
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2010, Volume: 118, Issue:2

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics

2010
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
    Toxicological sciences : an official journal of the Society of Toxicology, 2013, Volume: 136, Issue:1

    Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests

2013
Histamine H1 receptors in human brain visualized in vivo by [11C]doxepin and positron emission tomography.
    Neuroscience letters, 1992, Mar-30, Volume: 137, Issue:2

    Topics: Adult; Brain; Carbon Isotopes; Chlorpheniramine; Doxepin; Humans; Injections, Intravenous; Male; Pyrilamine; Receptors, Histamine H1; Tomography, Emission-Computed

1992
The effect of p-chloroamphetamine on motility in rats after inhibition of monoamine synthesis, storage, uptake and receptor interaction.
    Psychopharmacologia, 1974, Jan-14, Volume: 34, Issue:3

    Topics: Amitriptyline; Amphetamine; Animals; Biogenic Amines; Catecholamines; Chlorine; Chlorpheniramine; Chlorpromazine; Desipramine; Dibenzazepines; Dose-Response Relationship, Drug; Doxepin; Female; Haloperidol; Imipramine; Methyltyrosines; Motor Activity; Rats; Receptors, Cholinergic; Serotonin Antagonists; Spiro Compounds; Time Factors

1974
Histamine H1 receptor occupancy in human brains after single oral doses of histamine H1 antagonists measured by positron emission tomography.
    British journal of pharmacology, 1995, Volume: 116, Issue:1

    Topics: Administration, Oral; Adult; Animals; Brain; Carbon Radioisotopes; Chlorpheniramine; Doxepin; Guinea Pigs; Histamine H1 Antagonists; Humans; Male; Receptors, Histamine H1; Terfenadine; Tomography, Emission-Computed

1995
[Functional neuropharmacology in the human brain using positron emission tomography: PET imaging of impaired cognitive performance induced by sedative antihistamines].
    Nihon yakurigaku zasshi. Folia pharmacologica Japonica, 1998, Volume: 112 Suppl 1

    Topics: Animals; Brain; Chlorpheniramine; Cognition; Doxepin; Histamine Antagonists; Histamine H1 Antagonists; Humans; Male; Receptors, Histamine H1; Sleep Stages; Tomography, Emission-Computed

1998
Development and validation of a simultaneous analytical method for non-steroidal therapeutic compounds in cosmetics using liquid chromatography-tandem mass spectrometry.
    Journal of separation science, 2021, Volume: 44, Issue:12

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Bufexamac; Chlorpheniramine; Chromatography, High Pressure Liquid; Clotrimazole; Cosmetics; Doxepin; Fusidic Acid; Ketotifen; ortho-Aminobenzoates; Phthalazines; Tacrolimus; Tandem Mass Spectrometry

2021
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