dothiepin-hydrochloride and vinpocetine

The studies made showed that employment of amitriptylinum in patients presenting with depressive disturbances against the background of the organic affection of the brain resulted in origination od side effects, which fact failed to promote the reduction of depressive symptomatology. The use of azaphenum is not very effective. Protiadenum, a new antidepressant, does not induce side effects like amitriptylinum and was noted to be more effective than azaphenum. Protiadenum combined with nootropil and those drugs improving cerebral microcirculation (cavintonum) enhance efficiency of psychopharmacotherapy of depressive disorders in persons with organic affection of brain, who had become victims of the Chernobyl accident, which fact permits recommending such therapy in the complex of curative measures in the given contingent of patients.

Topics: Adult; Antidepressive Agents, Tricyclic; Depressive Disorder; Dothiepin; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Nootropic Agents; Piracetam; Power Plants; Radioactive Hazard Release; Ukraine; Vinca Alkaloids