dorzolamide and taxane

Taxanes are a class of microtubule stabilising agents used to treat a wide range of malignancies. Taxane drug-induced cystoid macula oedema (TDICMO) is a known but rare complication of therapy. First reported with Docetaxel in 2003 and Paclitaxel in 2007, there are currently less than 20 cases of TDICMO in the literature. Although most cases resolve following taxane cessation, several authors have tried using carbonic anhydrase inhibitors or intravitreal bevacizumab to accelerate resolution or when taxane therapy cannot be discontinued. We report the first published case of TDICMO treated with a single-eye trial of topical dorzolamide versus intravitreal bevacizumab.

Topics: Administration, Topical; Aged; Angiogenesis Inhibitors; Bevacizumab; Bridged-Ring Compounds; Carbonic Anhydrase Inhibitors; Humans; Intravitreal Injections; Macular Edema; Male; Sulfonamides; Taxoids; Thiophenes