dopamine-glucuronide and noradrenaline-sulfate

dopamine-glucuronide has been researched along with noradrenaline-sulfate* in 3 studies

Other Studies

3 other study(ies) available for dopamine-glucuronide and noradrenaline-sulfate

ArticleYear
Amine sulfate formation in the central nervous system.
    Federation proceedings, 1986, Volume: 45, Issue:8

    The sulfates of norepinephrine, dopamine (DA), and serotonin (5-hydroxytryptamine [5HT]) are present in the cerebrospinal fluid (CSF) of laboratory animals and humans. The amounts of sulfated amines in human CSF always greatly exceed the amounts of the free amines. The enzyme responsible for sulfation, phenol sulfotransferase (PST) (EC 2.8.2.1), has been detected in the brain tissue of several species, including humans. PST in the human brain has a high affinity for the amines but it is a low-capacity enzyme. Accordingly, sulfation appears to be of greater significance in the economy of the amines under quiescent conditions than during conditions of increased release of transmitter. Recent evidence suggests that a fraction of the conjugated amines in CSF enters from plasma because in the African green monkey, DA sulfate and 5HT sulfate cross the blood-CSF barrier after i.v. injection. In addition, in humans there are no increases in the concentration of amine sulfates from lumbar to ventricular CSF that would also be compatible with a partly peripheral origin for the amine sulfates. However, it appears that at least a portion of the amine sulfates in CSF originate in the central nervous system because the ratios of [CSF amine sulfates]/[plasma sulfates] are never as high after i.v. injection as under basal conditions.

    Topics: Animals; Arylsulfotransferase; Brain; Carbidopa; Chlorocebus aethiops; Contraceptives, Oral, Combined; Dopamine; Homovanillic Acid; Humans; Levodopa; Norepinephrine; Serotonin; Sulfurtransferases

1986
Free and conjugated catecholamines in digestive tissues of rats.
    Life sciences, 1985, Oct-21, Volume: 37, Issue:16

    Using a radioenzymatic technique, the highest concentrations of free catecholamines were found in the duodenum, and the lowest in the liver of untreated rats. When compared to the antrum, the concentration of free dopamine was higher, and that of norepinephrine lower in the fundus. As far as conjugated catecholamines are concerned, the tissue concentrations of both sulfo- and glucurono-conjugates were usually low, and often non detectable, with an exception: the concentration of glucurono-conjugated dopamine was very high in the duodenum, ileum, and liver of untreated rats.

    Topics: Animals; Dopamine; Duodenum; Epinephrine; Glucuronidase; Ileum; Intestine, Small; Liver; Norepinephrine; Rats; Stomach; Sulfatases; Tissue Distribution

1985
Role of conjugation and red blood cells for inactivation of circulating catecholamines.
    The American journal of physiology, 1984, Volume: 247, Issue:1 Pt 2

    We investigated the extent of catecholamine (CA) conjugation in plasma and accumulation inside red blood cells (RBCs) after forced immobilization of the rat. A control blood sample was obtained from undisturbed rats resting in home cages via an indwelling aortic catheter. Then rats were immobilized for 2 h, and blood samples were taken during stress at 15 min and 2 h and at 30 min poststress. Both sulfate and glucuronide conjugates were deconjugated by enzymatic hydrolysis and measured by radioenzymatic thin-layer chromatographic methods. In plasma of resting rats, the major conjugate of norepinephrine (NE) is sulfate and that of epinephrine (E) and dopamine (DA) is glucuronide; total conjugates in plasma are 53, 57, and 97% of total NE, E, and DA, respectively. During stress, sulfate conjugates of NE, E, and DA increased significantly along with free NE, E, and DA. DA glucuronide unexpectedly declined at 2 h of stress and 30 min poststress. Concentrations of free CAs rose in RBCs during stress, as did NE sulfate, the only conjugate present in RBC lysate. We conclude that both CA conjugation and RBC accumulation are enhanced when large amounts of free CA enter the circulation as a result of immobilization stress and that the relative importance of these inactivation pathways is different for the three CAs.

    Topics: Animals; Catecholamines; Chromatography, Thin Layer; Dopamine; Epinephrine; Erythrocytes; Glucuronates; Immobilization; Male; Norepinephrine; Rats; Rats, Gunn; Rats, Inbred Strains; Stress, Physiological

1984
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