Compounds > donepezil

donepezil and warfarin

donepezil has been researched along with warfarin in 15 studies

Research

Studies (15)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (6.67)	18.2507
2000's	2 (13.33)	29.6817
2010's	10 (66.67)	24.3611
2020's	2 (13.33)	2.80

Authors

Authors	Studies
Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ	1
Ekins, S; Williams, AJ; Xu, JJ	1
Honda, K; Izumi, T; Miyaji, Y; Nakayama, S; Okazaki, O; Okudaira, N; Shiosakai, K; Sugiyama, D; Suzuki, W; Takakusa, H; Watanabe, A	1
Chang, G; Di, L; Huang, Y; Lin, Z; Liston, TE; Scott, DO; Troutman, MD; Umland, JP	1
Ambroso, JL; Ayrton, AD; Baines, IA; Bloomer, JC; Chen, L; Clarke, SE; Ellens, HM; Harrell, AW; Lovatt, CA; Reese, MJ; Sakatis, MZ; Taylor, MA; Yang, EY	1
Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Foley, K; Friedhoff, LT; Tiseo, PJ	1
Andrisano, V; Bertucci, C; Cavrini, V; Gotti, R; Pomponio, R	1
Eto, F	1
Andrisano, V; Bartolini, M; Cavalli, A; Ceccarini, L; Gobbi, S; Piazzi, L; Rampa, A; Recanatini, M; Rizzo, S	1
Jiang, N; Kong, LY; Lan, JS; Li, F; Wang, J; Wang, X; Wang, ZM; Wu, JJ; Xie, SS	1
Chand, K; Hiremathad, A; Keri, RS	1
Bharate, SB; Gairola, S; Nuthakki, VK; Sharma, A; Singh, B	1
Gu, J; Li, F; Lian, B; Wu, X; Yu, M; Zhang, C; Zhao, AZ; Zou, Z	1

Reviews

2 review(s) available for donepezil and warfarin

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
[Treatment of vascular dementia]. Nihon rinsho. Japanese journal of clinical medicine, 2004, Volume: 62 Suppl Topics: Activities of Daily Living; Anticoagulants; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Humans; Indans; Patient Care Team; Piperidines; Quality of Life; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Warfarin	2004

Trials

1 trial(s) available for donepezil and warfarin

Article	Year
The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin. British journal of clinical pharmacology, 1998, Volume: 46 Suppl 1 Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anticoagulants; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Drug Interactions; Humans; Indans; Male; Middle Aged; Piperidines; Warfarin	1998

Other Studies

12 other study(ies) available for donepezil and warfarin

Article	Year
Developing structure-activity relationships for the prediction of hepatotoxicity. Chemical research in toxicology, 2010, Jul-19, Volume: 23, Issue:7 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; Tetracyclines; Thiophenes	2010
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals, 2010, Volume: 38, Issue:12 Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands	2010
Combination of GSH trapping and time-dependent inhibition assays as a predictive method of drugs generating highly reactive metabolites. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Glutathione; Pharmacology; Sulfur Radioisotopes	2011
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals, 2011, Volume: 39, Issue:7 Topics: Animals; Brain; Dogs; Guinea Pigs; Humans; Macaca fascicularis; Mice; Rats; Species Specificity	2011
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds. Chemical research in toxicology, 2012, Oct-15, Volume: 25, Issue:10 Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Decision Trees; Drug Evaluation, Preclinical; Drug-Related Side Effects and Adverse Reactions; Glutathione; Humans; Liver; Pharmaceutical Preparations; Protein Binding	2012
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals, 2012, Volume: 40, Issue:12 Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship	2012
Study of donepezil binding to serum albumin by capillary electrophoresis and circular dichroism. Analytical and bioanalytical chemistry, 2003, Volume: 377, Issue:5 Topics: Bilirubin; Binding Sites; Bromphenol Blue; Circular Dichroism; Donepezil; Electrophoresis, Capillary; Humans; Indans; Ketoprofen; Piperidines; Protein Binding; Reproducibility of Results; Serum Albumin; Time Factors; Warfarin	2003
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238. Bioorganic & medicinal chemistry, 2010, Mar-01, Volume: 18, Issue:5 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Combined Chemotherapy Protocols; Benzylamines; Binding Sites; Bleomycin; Cholinesterase Inhibitors; Computer Simulation; Coumarins; Donepezil; Humans; Indans; Lomustine; Methotrexate; Peptide Fragments; Piperidines; Recombinant Proteins; Stilbenes; Structure-Activity Relationship; Tetrahydronaphthalenes	2010
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease. Bioorganic & medicinal chemistry, 2016, Apr-01, Volume: 24, Issue:7 Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Donepezil; Dose-Response Relationship, Drug; Drug Design; Eels; Humans; Indans; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Structure-Activity Relationship	2016
Development of coumarin-benzofuran hybrids as versatile multitargeted compounds for the treatment of Alzheimer's Disease. Chemical biology & drug design, 2018, Volume: 92, Issue:2 Topics: Alzheimer Disease; Amyloid beta-Peptides; Benzofurans; Binding Sites; Cholinesterase Inhibitors; Coumarins; Donepezil; Drug Design; Humans; Molecular Docking Simulation; Peptide Fragments; Structure-Activity Relationship	2018
A Coumarin-Donepezil Hybrid as a Blood-Brain Barrier Permeable Dual Cholinesterase Inhibitor: Isolation, Synthetic Modifications, and Biological Evaluation of Natural Coumarins. ChemMedChem, 2022, 09-16, Volume: 17, Issue:18 Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Blood-Brain Barrier; Chalcones; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Donepezil; Humans; Molecular Docking Simulation; Structure-Activity Relationship	2022
Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway. Metabolic brain disease, 2022, Volume: 37, Issue:8 Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Cognition; Coumarins; Cyclic AMP Response Element-Binding Protein; Donepezil; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Maze Learning; Memory; Memory Disorders; Mice; Scopolamine; Signal Transduction	2022