donepezil has been researched along with scopolamine hydrobromide in 104 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (6.73) | 18.2507 |
| 2000's | 29 (27.88) | 29.6817 |
| 2010's | 51 (49.04) | 24.3611 |
| 2020's | 17 (16.35) | 2.80 |
| Authors | Studies |
|---|---|
| Chaudhaery, SS; Nath, C; Nazir, A; Roy, KK; Sammi, SR; Saxena, AK; Saxena, G; Shakya, N | 1 |
| Cantin, LD; Chen, H; Kenna, JG; Noeske, T; Stahl, S; Walker, CL; Warner, DJ | 1 |
| Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K | 1 |
| Cai, P; Kong, LY; Liu, QH; Wang, XB; Wang, ZM; Wu, JJ; Xu, DQ; Yang, XL | 1 |
| Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M | 1 |
| Cheng, DH; Ren, H; Tang, XC | 1 |
| Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H | 1 |
| Kojima, J; Nakajima, K; Nakayama, K; Ochiai, M | 1 |
| Poorheidari, G; Pratt, JA; Stanhope, KJ | 1 |
| Braida, D; Colibretti, L; Griffini, P; Lamperti, M; Paladini, E; Sala, M | 1 |
| Tang, XC; Wang, T | 1 |
| Braida, D; Ottonello, F; Sala, M; Virag, W | 1 |
| Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y | 1 |
| Higashi, M; Kawashima, S; Matsuno, T; Yamaguchi, Y | 1 |
| Chen, Z; Li, R; Wei, EQ; Xu, AJ | 1 |
| Enderlin, M; Fimbel, R; Gill, R; Grottick, AJ; Haman, M; Higgins, GA; Kemp, JA; Richards, JG; Soriano, M | 1 |
| Matsuoka, N; Mutoh, S; Tokita, K; Yamazaki, M; Yamazaki, S | 1 |
| Bontempi, B; Lloyd, GK; Menzaghi, F; Risbrough, VB; Whelan, KT | 1 |
| Davis, JM; Janowsky, DS; Overstreet, DH | 1 |
| Spowart-Manning, L; van der Staay, FJ | 1 |
| Bouger, PC; van der Staay, FJ | 1 |
| Kusumoto, H; Minami, A; Shimazu, S; Takahata, K; Yoneda, F | 1 |
| Miki, A; Morimoto, T; Okada, M; Otori, Y; Tano, Y | 1 |
| Anggadiredja, K; Hiranita, T; Nawata, Y; Sakimura, K; Yamamoto, T | 1 |
| Kotani, S; Ogura, H; Teramoto, T; Yamauchi, T | 1 |
| Chen, P; Corsa, JA; Gillman, KW; Gribkoff, VK; Hodges, DB; Hogan, JB; Jones, KM; Leet, JE; Lindner, MD; Orie, AF; Rose, GM | 1 |
| Bouchard, K; Hohnadel, E; Terry, AV | 1 |
| Murai, T; Ohta, H; Okuda, S; Tanaka, T | 1 |
| Adachi, Y; Fujii, Y; Kamei, C; Yamamoto, Y | 1 |
| Bouchard, KA; Buccafusco, JJ; Hohnadel, EJ; Martin, D; Terry, AV; Warner, SE; Webster, SJ | 1 |
| Blokland, A; Riedel, WJ; Sambeth, A; Smits, LT | 1 |
| Kamei, C; Masuoka, T; Mikami, A; Yamamoto, Y; Yasuda, M | 1 |
| Belzung, C; Cachard-Chastel, M; Devers, S; Gardier, AM; Langlois, M; Lezoualc'h, F; Sicsic, S | 1 |
| Agrawal, R; Nath, C; Shukla, R; Tyagi, E | 1 |
| Bednar, M; Jackson, CE; Maruff, P; Pietrzak, RH; Snyder, PJ; Thomas, E | 1 |
| Aluisio, L; Boggs, JD; Bonaventure, P; Fraser, IC; Galici, R; Lord, B; Lovenberg, TW | 1 |
| Choi, DY; Kang, SH; Platt, B; Riedel, G | 1 |
| Dardenne, B; Detrait, ER; Hanon, E; Lamberty, Y | 1 |
| Kamei, C; Masuoka, T | 1 |
| Asai, M; Fujikawa, A; Matsuoka, N; Miyoshi, S; Nishimura, S; Noda, A | 1 |
| Bartko, SJ; Bussey, TJ; Saksida, LM; Vendrell, I | 1 |
| Hayashida, M; Matsumoto, K; Miyata, T; Shibahara, N; Tanaka, K; Yamada, M; Zhao, Q | 1 |
| Araujo, JA; de Rivera, C; Greig, NH; Ingram, DK; Milgram, NW; Sandin, J | 1 |
| Calder, N; Cho, W; Connell, J; Doran, S; Fox-Bosetti, S; Gargano, C; Hassan, A; Herman, G; Lines, C; Maruff, P; Renger, J; Verma, A | 1 |
| Akkerman, S; de Bruin, NM; de Groote, L; Houba, P; Kruse, CG; Prickaerts, J; Reneerkens, O; van Loevezijn, A; Venhorst, J | 1 |
| Abi-Saab, W; Baker, JD; Lenz, RA; Locke, C; Mohler, EG; Rueter, LE; Saltarelli, MD; Wesnes, K | 1 |
| Blokland, A; Klinkenberg, I; Sambeth, A | 1 |
| Chung, J; Han, MJ; Jang, SE; Joh, EH; Jung, IH; Kim, DH | 1 |
| Harel, BT; Maruff, P; Pietrzak, RH; Snyder, PJ | 1 |
| Beniashvily, AG; Bondarenko, EV; Burminskiy, DS; Ivachtchenko, AV; Kazey, VI; Lavrovsky, Y; Lepilkina, TA; Morozova, MA; Potanin, SS; Rupchev, GE | 1 |
| Mishra, N; Sasmal, D; Singh, KK | 1 |
| Jayarajan, P; Nirogi, R; Shinde, A | 1 |
| Aderibigbe, AO; Adewole, FA; Eduviere, AT; Onwuchekwa, C; Umukoro, S | 1 |
| Gawel, K; Jenda, M; Kotlinska, JH; Labuz, K; Silberring, J | 1 |
| Chandrashekar, BR; Christopher, R; Kishore, MK; Mohanbabu, AV; Nandit, PB; Pradeepa, HD | 1 |
| Ahnaou, A; Drinkenburg, WH; Huysmans, H; Jacobs, T | 1 |
| Eom, MR; Jung, YS; Lee, J; Ma, CJ; Weon, JB | 1 |
| Hasanein, P; Mahtaj, AK | 1 |
| Hashimoto, T; Hatayama, Y; Nakamichi, K; Yoshida, N | 1 |
| Arab, HH; El-Maraghy, SA; Rizk, SM; Safar, MM | 1 |
| Bajda, M; Brus, B; Czerwińska, P; Filipek, B; Gobec, S; Malawska, B; Sałat, K; Więckowska, A; Więckowski, K | 1 |
| Gong, YX; Li, XF; Liu, LF; Luo, HY; Zhao, XY; Zheng, XH; Zhong, JQ; Zhu, QF | 1 |
| Ghumatkar, PJ; Jain, PD; Patil, SP; Sathaye, S; Tambe, RM | 1 |
| Bordet, R; Boucart, M; Bubbico, G; Defoort, S; Deguil, J; Deplanque, D; Ponchel, A; Szaffarczyk, S; Waucquier, N | 1 |
| Cannon, CE; Drott, JT; Kuduk, SD; Lange, HS; Uslaner, JM | 1 |
| Akkerman, S; Blokland, A; Prickaerts, J | 1 |
| Akkerman, S; Blokland, A; Creemers, P; De Vry, J; Prickaerts, J; Sambeth, A; Uz, T; van Duinen, M; Vanmierlo, T | 1 |
| Li, W; Ma, L; Qin, L; Yang, P; Zhang, J | 1 |
| Chen, X; Cui, W; Han, Y; Hu, S; Hu, Z; Huang, L; Lin, J; Mak, S; Nirasha, S; Wang, C; Wang, Q; Wei, X; Xiang, S; Xu, D; Xu, S; Yu, J; Zhang, J; Zhang, Z; Zhao, K; Zheng, J; Zhou, D; Zhou, W | 1 |
| Gawel, K; Gibula-Bruzda, E; Jenda, M; Kotlinska, JH; Labuz, K; Marszalek-Grabska, M; Silberring, J | 1 |
| Fernandez, AP; Futch, HS; Herrero-Labrador, R; Marco-Contelles, J; Martínez-Murillo, R; Romero, A; Samadi, A; Serrano, J; Serrano, MP; Unzeta, M | 1 |
| Cerman, J; Gazova, I; Harrison, J; Hort, J; Klovrzova, S; Laczó, J; Lobellova, V; Markova, H; Nekovarova, T; Parizkova, M; Stuchlik, A; Svoboda, J; Vales, K; Vlcek, K; Windisch, M | 1 |
| Akinyemi, AJ; Oboh, G; Ogunsuyi, O; Oyeleye, SI | 1 |
| Choudhary, S; Kaur, J; Malik, J | 1 |
| Brodney, MA; Davoren, JE; Edgerton, JR; Fortin, JP; Garnsey, M; Grimwood, S; Harris, AR; Jenkinson, S; Kenakin, T; Lazzaro, JT; Lee, CW; Lotarski, SM; Nottebaum, L; O'Neil, SV; Pettersen, B; Popiolek, M; Ramsey, S; Steyn, SJ; Thorn, CA; Webb, D; Zhang, L | 1 |
| Kaur, R; Shri, R; Singh, V | 1 |
| Benade, V; Bhyrapuneni, G; Daripelli, S; Jayarajan, P; Nirogi, R; Tirumalasetty, C | 1 |
| Benitex, Y; Bookbinder, M; Bristow, LJ; Keavy, D; King, D; Macor, JE; Morgan, DG; Olson, R; Polino, J; Signor, L; Weed, MR; Zaczek, R | 1 |
| Blake, DT; Callahan, PM; Constantinidis, C; Crawford, J; Liu, R; Terry, AV | 1 |
| Abraham, R; Benade, V; Bhyrapuneni, G; Jasti, V; Jayarajan, P; Kambhampati, R; Medapati, RB; Mekala, VR; Muddana, N; Nirogi, R; Shinde, A; Subramanian, R | 1 |
| Graf, R; Hughes, ZA; Longo, JL | 1 |
| de Bem, AF; de Sousa, G; Faria, MS; Machado, AE; Mancini, G; Moreira, ELG | 1 |
| Mirshekar, MA; Shabani, S | 1 |
| Kimura, H; Kurimoto, E; Nakashima, M; Suzuki, M | 1 |
| Chen, JQ; Duan, JA; Kang, A; Liu, P; Ma, JY; Pu, ZJ; She, W; Shi, XQ; Tan, YJ; Tang, YP; Tao, HJ; Wang, J; Zhang, J; Zhou, GS; Zhu, Y; Zhu, ZH | 1 |
| Ren, T; Wang, Q; Yang, M; Zhang, Y; Zhao, J; Zuo, Z | 1 |
| Abou-Seri, SM; Akincioglu, H; El-Sayed, NA; Ezzat, MAF; Farag, AE; Gülçin, İ | 1 |
| Aydin, S; Erol, K; Kaygisiz, B; Kilic, FS; Oner, S; Yildirim, E | 1 |
| Gzielo, K; Krawczyk, M; Nikiforuk, A; Popik, P; Potasiewicz, A | 1 |
| Boiangiu, RS; Brinza, I; Cioanca, O; Erdogan Orhan, I; Eren, G; Ertas, H; Gündüz, E; Hancianu, M; Hritcu, L | 1 |
| Hernádi, I; Knakker, B; Lendvai, B; Oláh, V; Trunk, A | 1 |
| Adebayo, AA; Ademosun, AO; Oboh, G; Popoola, TV | 1 |
| Hernádi, I; Knakker, B; Lendvai, B; Lévay, G; Oláh, V; Trunk, A | 1 |
| Aquino, J; Barros, M; Costa, CS; Maior, RS; Oliveira, AWC; Pacheco, JVN | 1 |
| Ijomone, OM; Oboh, G; Ogunsuyi, OB; Omage, FB; Rocha, JBT | 1 |
| Gu, J; Li, F; Lian, B; Wu, X; Yu, M; Zhang, C; Zhao, AZ; Zou, Z | 1 |
| Bhatt, H; Borisa, A; Faldu, K; Patel, P; Shah, J | 1 |
| Charvériat, M; Droguerre, M; Mouthon, F; Pereira, M; Valdebenito, M; Vidal, B; Vidal, L; Zimmer, L | 1 |
| Anoush, M; Bijani, S; Ebrahimi, M; Hosseini, MJ; Tayebi, N; Yazdinezhad, AR | 1 |
| da Silva, JKR; de Campos, DL; Fontes-Junior, EA; Maia, CSF; Maia, JGS; Pinheiro, BG; Queiroz, LY | 1 |
| Cunico, W; de Aguiar, MSS; de Mello, JE; de Souza Cardoso, J; Dos Santos, A; Luduvico, KP; Spanevello, R; Stefanello, F; Teixeira, FC; Vizzotto, M | 1 |
| Pattnaik, S; Yadav, YC | 1 |
| Bhatta, RS; Handa, M; Palkhade, R; Patil, GP; Sanap, SN; Shukla, R; Singh, DP | 1 |
| Adeniyi, IA; Adesanya, A; Ajayi, AM; Olayinka, GS; Olubori, MA; Onasanwo, SA; Oregbesan, PO | 1 |
1 review(s) available for donepezil and scopolamine hydrobromide
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk | 2016 |
6 trial(s) available for donepezil and scopolamine hydrobromide
| Article | Year |
|---|---|
Specific impairments in visuospatial working and short-term memory following low-dose scopolamine challenge in healthy older adults.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Geriatric Assessment; Humans; Indans; Linear Models; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Piperidines; Scopolamine; Spatial Behavior | 2008 |
Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans.
Topics: Adult; Area Under Curve; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Inverse Agonism; Drug Therapy, Combination; Histamine Agonists; Humans; Indans; Male; Maze Learning; Piperidines; Receptors, Histamine H3; Scopolamine; Young Adult | 2011 |
The scopolamine model as a pharmacodynamic marker in early drug development.
Topics: Adult; Animals; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Male; Maze Learning; Memory; Middle Aged; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Long-Evans; Scopolamine; Single-Blind Method; Species Specificity; Time Factors; Young Adult | 2012 |
Effect of cholinergic neurotransmission modulation on visual spatial paired associate learning in healthy human adults.
Topics: Adolescent; Adult; Cholinesterase Inhibitors; Cognition Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Executive Function; Humans; Indans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Paired-Associate Learning; Piperidines; Scopolamine; Time Factors; Young Adult | 2013 |
Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study.
Topics: Adult; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Middle Aged; Pilot Projects; Piperidines; Prepulse Inhibition; Pyrazoles; Pyrimidines; Reaction Time; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Scopolamine; Serotonin Antagonists; Tacrine; Treatment Outcome; Young Adult | 2014 |
Scopolamine disrupts place navigation in rats and humans: a translational validation of the Hidden Goal Task in the Morris water maze and a real maze for humans.
Topics: Adult; Animals; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Maze Learning; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Spatial Navigation; Young Adult | 2017 |
97 other study(ies) available for donepezil and scopolamine hydrobromide
| Article | Year |
|---|---|
Novel carbamates as orally active acetylcholinesterase inhibitors found to improve scopolamine-induced cognition impairment: pharmacophore-based virtual screening, synthesis, and pharmacology.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Avoidance Learning; Caenorhabditis elegans; Carbamates; Catalytic Domain; Cholinesterase Inhibitors; Databases, Factual; Hydrogen Bonding; Hydrophobic and Hydrophilic Interactions; Male; Mice; Models, Molecular; Nootropic Agents; Quantitative Structure-Activity Relationship; Scopolamine | 2010 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Bile Acids and Salts; Cell Line; Chemical and Drug Induced Liver Injury; Humans; Quantitative Structure-Activity Relationship | 2012 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation | 2016 |
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1996 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1996 |
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed | 1997 |
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Motor Activity; Piperidines; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine; Tacrine | 1997 |
Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: a comparison with the cholinesterase inhibitor E2020.
Topics: 4-Aminopyridine; Animals; Apamin; Choice Behavior; Cholinesterase Inhibitors; Conditioning, Operant; Donepezil; Indans; Male; Muscarinic Antagonists; Piperidines; Potassium Channel Blockers; Potassium Channels; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine | 1998 |
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Topics: Amnesia; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Male; Maze Learning; Morpholines; Motor Activity; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1998 |
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine | 2000 |
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
Topics: Animals; Avoidance Learning; Basal Nucleus of Meynert; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning Disabilities; Male; Maze Learning; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 2000 |
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Choline O-Acetyltransferase; Cognition; Donepezil; Dose-Response Relationship, Drug; Enzyme Induction; Hippocampus; Indans; Male; Maze Learning; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2001 |
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Memory Disorders; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2002 |
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia.
Topics: Alzheimer Disease; Animals; Brain Infarction; Brain Ischemia; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Male; Memory Disorders; Muscarinic Antagonists; Perforant Pathway; Piperidines; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Scopolamine | 2002 |
Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats.
Topics: Aging; Animals; Avoidance Learning; Basal Nucleus of Meynert; Benzamides; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Indans; Male; Memory Disorders; Nootropic Agents; Piperazines; Piperidines; Rats; Rats, Wistar; Scopolamine | 2002 |
Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors.
Topics: Age Factors; Animals; Attention; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cognition; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Indans; Lethal Dose 50; Male; Mecamylamine; Memory, Short-Term; Mice; Mice, Inbred C57BL; Motor Activity; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenols; Piperidines; Psychomotor Performance; Pyrrolidines; Reaction Time; Receptors, Nicotinic; Scopolamine; Seizures | 2003 |
Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study.
Topics: Animals; Behavior, Animal; Body Temperature; Cholinesterase Inhibitors; Diarrhea; Donepezil; Drug Interactions; Indans; Isoflurophate; Male; Motor Activity; Muscarinic Antagonists; Neurotoxicity Syndromes; Piperidines; Rats; Scopolamine | 2004 |
The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Drug Administration Routes; Exploratory Behavior; Indans; Maze Learning; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Piperidines; Reaction Time; Reproducibility of Results; Scopolamine; Space Perception; Species Specificity; Time Factors | 2004 |
Effects of the cholinesterase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats.
Topics: Animals; Brain; Cholinesterase Inhibitors; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Memory, Short-Term; Mental Recall; Motivation; Motor Activity; Nootropic Agents; Orientation; Piperidines; Rats; Rats, Wistar; Reaction Time; Scopolamine; Space Perception; Trichlorfon | 2005 |
Effects of selegiline alone or with donepezil on memory impairment in rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Aziridines; Behavior, Animal; Choline; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Escape Reaction; Fenclonine; Indans; Male; Maze Learning; Memory Disorders; Piperidines; Rats; Rats, Inbred F344; Reaction Time; Scopolamine; Selegiline; Time Factors | 2005 |
Protective effect of donepezil on retinal ganglion cells in vitro and in vivo.
Topics: Administration, Oral; Animals; Axotomy; Benzopyrans; Cell Survival; Cells, Cultured; Cholinergic Antagonists; Cholinesterase Inhibitors; Cytoprotection; Donepezil; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutamic Acid; Indans; Mecamylamine; Neuroprotective Agents; Nitriles; Optic Nerve Injuries; Piperidines; Rats; Retinal Ganglion Cells; Scopolamine | 2006 |
Suppression of methamphetamine-seeking behavior by nicotinic agonists.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Lidocaine; Male; Mecamylamine; Methamphetamine; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine | 2006 |
Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cholinergic Agents; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Immunohistochemistry; Indans; Male; Neural Inhibition; Neurons; Organogenesis; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine | 2006 |
Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping.
Topics: Animals; Attention; Cholinesterase Inhibitors; Cognition Disorders; Conditioning, Psychological; Donepezil; Indans; Male; Maze Learning; Memory; Muscarinic Antagonists; Piperidines; Psychomotor Disorders; Rats; Rats, Sprague-Dawley; Scopolamine | 2006 |
Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Gait Disorders, Neurologic; Galantamine; Indans; Inhibition, Psychological; Male; Nootropic Agents; Piperidines; Rats; Reflex, Startle; Scopolamine | 2007 |
Characteristics of object location memory in mice: Behavioral and pharmacological studies.
Topics: Age Factors; Analysis of Variance; Animals; Association Learning; Behavioral Research; Cholinesterase Inhibitors; Donepezil; Exploratory Behavior; Indans; Male; Memory; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Piperidines; Scopolamine; Sensitivity and Specificity; Space Perception; Spatial Behavior; Statistics, Nonparametric | 2007 |
Ginkgo biloba extract improves spatial memory in rats mainly but not exclusively via a histaminergic mechanism.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Diphenhydramine; Donepezil; Ginkgo biloba; Histamine; Histamine H1 Antagonists; Indans; Male; Maze Learning; Memory; Memory Disorders; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Piperidines; Plant Extracts; Pyrilamine; Rats; Rats, Wistar; Scopolamine; Synaptic Transmission; Treatment Outcome | 2007 |
The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates.
Topics: Aging; Animals; Cholinesterase Inhibitors; Computers; Conditioning, Operant; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indans; Macaca mulatta; Male; Maze Learning; Memory; Muscarinic Antagonists; Piperidines; Psychomotor Performance; Rats; Rats, Long-Evans; Rats, Wistar; Scopolamine | 2008 |
Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG?
Topics: Animals; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Indans; Male; Memory; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Scopolamine | 2007 |
Participation of cholinergic system in memory deficits induced by blockade of hippocampal mGlu(1) receptors.
Topics: Animals; Cholinergic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Indans; Male; Maze Learning; Mecamylamine; Memory Disorders; Piperidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Scopolamine | 2007 |
Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice.
Topics: Amyloid beta-Protein Precursor; Analysis of Variance; Aniline Compounds; Animals; Benzofurans; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Hippocampus; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Motor Activity; Nootropic Agents; Piperidines; Scopolamine; Serotonin 5-HT4 Receptor Agonists; Statistics, Nonparametric | 2008 |
Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Brain; Cholinergic Fibers; Donepezil; Hypoglycemic Agents; Indans; Insulin; Male; Melatonin; Mice; Motor Activity; Nootropic Agents; Piperidines; Reaction Time; Scopolamine; Transfer, Psychology | 2008 |
JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Cholinesterase Inhibitors; Cognition; Conditioning, Operant; Donepezil; Drinking Behavior; Drug Evaluation, Preclinical; Histamine Agonists; Histamine Antagonists; Imidazoles; Indans; Learning; Microdialysis; Morpholines; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Scopolamine; Synaptic Transmission; Thiourea | 2009 |
Scopolamine-induced deficits in social memory in mice: reversal by donepezil.
Topics: Animals; Anti-Anxiety Agents; Cholinesterase Inhibitors; Diazepam; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Indans; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neuropsychological Tests; Nootropic Agents; Piperidines; Random Allocation; Scopolamine; Social Behavior; Time Factors | 2009 |
The inhibitory avoidance test optimized for discovery of cognitive enhancers.
Topics: Animals; Avoidance Learning; Donepezil; Drug Evaluation, Preclinical; Drug Interactions; Indans; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Scopolamine; Tacrine | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Learning Disabilities; Male; Maze Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Theta Rhythm | 2009 |
Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys.
Topics: Animals; Brain; Cholinesterase Inhibitors; Consciousness; Donepezil; Drug Combinations; Fluorodeoxyglucose F18; Glucose; Indans; Macaca mulatta; Male; Piperidines; Positron-Emission Tomography; Scopolamine | 2009 |
A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.
Topics: Animals; Automation; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cues; Dicyclomine; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indans; Male; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Nootropic Agents; Paired-Associate Learning; Piperidines; Reaction Time; Reward; Scopolamine; Time Factors; Touch; User-Computer Interface | 2011 |
Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice.
Topics: Alzheimer Disease; Animals; Choline O-Acetyltransferase; Cognition Disorders; Conditioning, Psychological; Disease Models, Animal; Donepezil; Down-Regulation; Drugs, Chinese Herbal; Fear; Indans; Learning; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; Olfactory Bulb; Phytotherapy; Piperidines; Poria; Receptors, Muscarinic; Scopolamine | 2011 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine | 2011 |
Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Exploratory Behavior; Guanidines; Indans; Male; Maze Learning; Memory Disorders; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Scopolamine; Serotonin Antagonists; Sulfonamides | 2011 |
Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Biperiden; Cholinergic Neurons; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Electroencephalography; Evoked Potentials, Auditory; Hippocampus; Indans; Male; Muscarinic Antagonists; Nerve Tissue Proteins; Piperidines; Rats; Rats, Wistar; Receptor, Muscarinic M1; Schizophrenia; Scopolamine; Sensory Gating | 2013 |
Lancemaside A isolated from Codonopsis lanceolata and its metabolite echinocystic acid ameliorate scopolamine-induced memory and learning deficits in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Codonopsis; Cyclic AMP Response Element-Binding Protein; Donepezil; Dose-Response Relationship, Drug; Indans; Intestinal Mucosa; Intestines; Learning Disabilities; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Oleanolic Acid; Phytotherapy; Piperidines; Plant Extracts; Rhizome; Scopolamine | 2012 |
Attenuating Aβ1-42-induced toxicity by a novel acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Anthracenes; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Glutathione; Immunohistochemistry; Indans; Male; Maze Learning; Memory; Memory Disorders; Mice; Microscopy, Electron, Scanning; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Muscarinic Antagonists; Oxidation-Reduction; Peptide Fragments; Piperidines; Psychomotor Performance; Pyrazoles; Scopolamine; Tissue Fixation | 2013 |
Effect of olanzapine on scopolamine induced deficits in differential reinforcement of low rate 72s (DRL-72s) schedule in rats: involvement of the serotonergic receptors in restoring the deficits.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Cholinesterase Inhibitors; Conditioning, Operant; Donepezil; Haloperidol; Impulsive Behavior; Indans; Male; Muscarinic Antagonists; Olanzapine; Piperidines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reinforcement, Psychology; Scopolamine; Serotonin Antagonists; Sulfones | 2013 |
Free radical scavenging effect of donepezil as the possible contribution to its memory enhancing activity in mice.
Topics: Animals; Antioxidants; Biomarkers; Donepezil; Free Radical Scavengers; Free Radicals; Glutathione; Indans; Lipopolysaccharides; Male; Malondialdehyde; Memory; Memory Disorders; Mice; Oxidative Stress; Piperidines; Scopolamine | 2014 |
Influence of cholinesterase inhibitors, donepezil and rivastigmine on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference in rats.
Topics: Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Donepezil; Drug-Seeking Behavior; Indans; Male; Mecamylamine; Morphine; Motor Activity; Muscarinic Antagonists; Narcotics; Nicotinic Antagonists; Phenylcarbamates; Piperidines; Rats, Wistar; Rivastigmine; Scopolamine; Space Perception | 2014 |
Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats.
Topics: Administration, Oral; Amnesia; Animals; Cognition; Donepezil; Dose-Response Relationship, Drug; Indans; Maze Learning; Piperidines; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Scopolamine; Vitex | 2015 |
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential.
Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm | 2014 |
Cognitive enhancing effect of the fermented Gumiganghwal-tang on scopolamine-induced memory impairment in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Dietary Supplements; Disease Models, Animal; Donepezil; Fermentation; GPI-Linked Proteins; Hippocampus; Indans; Male; Maze Learning; Memory Disorders; Mice, Inbred ICR; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Nootropic Agents; Piperidines; Plant Extracts; Republic of Korea; Scopolamine | 2016 |
Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Cholinergic Antagonists; Cinnamates; Depsides; Donepezil; Indans; Male; Memory; Memory Disorders; Neuroprotective Agents; Piperidines; Rats, Wistar; Reaction Time; Rosmarinic Acid; Scopolamine | 2015 |
Procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice.
Topics: Aging; Animals; Donepezil; Drug Synergism; Flumazenil; GABA-A Receptor Agonists; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Naphthyridines; Nootropic Agents; Oxadiazoles; Piperidines; Rats; Scopolamine | 2014 |
Bone Marrow-Derived Endothelial Progenitor Cells Protect Against Scopolamine-Induced Alzheimer-Like Pathological Aberrations.
Topics: Adipose Tissue; Alzheimer Disease; Animals; Cell Movement; Cells, Cultured; Cognition Disorders; Cytokines; Disease Models, Animal; Donepezil; Endothelial Progenitor Cells; Gene Expression Profiling; Hippocampus; Indans; Intercellular Signaling Peptides and Proteins; Learning Disabilities; Male; Maze Learning; Mesenchymal Stem Cell Transplantation; Nerve Tissue Proteins; Neurotransmitter Agents; Piperidines; Random Allocation; Rats; Rats, Wistar; Scopolamine | 2016 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2015 |
[Design, synthesis and biological evaluation of novel [1,3] dioxolo [4,5-f]isoindolone derivatives].
Topics: Animals; Cholinesterase Inhibitors; Dioxoles; Donepezil; Drug Design; Indans; Inhibitory Concentration 50; Isoindoles; Memory Disorders; Mice; Piperidines; Scopolamine | 2015 |
Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cognition Disorders; Donepezil; Glial Fibrillary Acidic Protein; Indans; Male; Maze Learning; Mice; Motor Activity; Muscarinic Agonists; Neuroprotective Agents; Nootropic Agents; Phloretin; Piperidines; Scopolamine | 2015 |
Donepezil increases contrast sensitivity for the detection of objects in scenes.
Topics: Adult; Cholinergic Antagonists; Cholinesterase Inhibitors; Contrast Sensitivity; Donepezil; Humans; Indans; Male; Pattern Recognition, Visual; Piperidines; Reaction Time; Scopolamine; Signal Detection, Psychological; Young Adult | 2015 |
The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys.
Topics: Animals; Association Learning; Attention; Cholinesterase Inhibitors; Cognition; Discrimination, Psychological; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Memory; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Psychomotor Performance; Quinolizines; Receptor, Muscarinic M1; Scopolamine | 2015 |
Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach.
Topics: Animals; Cholinesterase Inhibitors; Discrimination, Psychological; Donepezil; Indans; Learning; Male; Memory; Phosphodiesterase 5 Inhibitors; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Rolipram; Scopolamine; Vardenafil Dihydrochloride | 2016 |
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Donepezil; Indans; Male; Memory; Mice; Mice, Inbred C57BL; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Piperidines; Rats, Wistar; Recognition, Psychology; Rolipram; Scopolamine; Spatial Memory; Vomiting | 2016 |
Cholinergic modulation of auditory steady-state response in the auditory cortex of the freely moving rat.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Electrodes, Implanted; Indans; Male; Microelectrodes; Piperidines; Rats, Wistar; Scopolamine | 2016 |
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Indans; Indoles; Male; Maze Learning; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Piperidines; Pyrroles; Scopolamine; Sunitinib | 2016 |
Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine.
Topics: Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Donepezil; Ethanol; Indans; Male; Mecamylamine; Muscarinic Antagonists; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Reinforcement, Psychology; Rivastigmine; Scopolamine | 2016 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Gliosis; Hep G2 Cells; Hippocampus; Humans; Indans; Indoles; Learning; Male; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Plaque, Amyloid; Proof of Concept Study; Recognition, Psychology; Scopolamine; Tacrine | 2017 |
Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System.
Topics: Adenosine Deaminase; Animals; Brain; Catalase; Cholinergic Neurons; Cholinesterase Inhibitors; Curcumin; Donepezil; Drug Synergism; Glutathione; Indans; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Nitric Oxide; Piperidines; Rats; Recognition, Psychology; Scopolamine; Superoxide Dismutase | 2017 |
Standardized extract of Lactuca sativa Linn. and its fractions abrogates scopolamine-induced amnesia in mice: A possible cholinergic and antioxidant mechanism.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior, Animal; Catalase; Cholinergic Agents; Donepezil; Dose-Response Relationship, Drug; Glutathione; Indans; Lactuca; Male; Malondialdehyde; Maze Learning; Memory; Mice; Nitrites; Piperidines; Plant Extracts; Plant Leaves; Scopolamine; Superoxide Dismutase | 2018 |
Design and Synthesis of γ- and δ-Lactam M
Topics: Allosteric Regulation; Amphetamine; Animals; Ataxia; Diarrhea; Dogs; Donepezil; Drug Design; Female; Humans; Indans; Isoindoles; Lactams; Male; Mice, Inbred C57BL; Microsomes, Liver; Oxazoles; Piperidines; Rats, Wistar; Receptor, Muscarinic M1; Scopolamine; Seizures; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Vomiting | 2017 |
Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Behavior, Animal; Biphenyl Compounds; Brain; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Ganoderma; GPI-Linked Proteins; Indans; Male; Memory; Mice; Nootropic Agents; Picrates; Piperidines; Reaction Time; Recognition, Psychology; Scopolamine; Time Factors | 2017 |
Simultaneous monitoring of electroencephalographic characteristics in animals subjected to behavioral tests: a preclinical investigation.
Topics: Amphetamine; Animals; Brain; Central Nervous System Agents; Donepezil; Electrocorticography; Electrodes, Implanted; Exploratory Behavior; Indans; Male; Motor Activity; Neuropsychological Tests; Piperidines; Rats, Wistar; Recognition, Psychology; Scopolamine; Telemetry | 2017 |
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Donepezil; Indans; Macaca fascicularis; Male; Paired-Associate Learning; Piperidines; Quinuclidines; Reaction Time; Scopolamine; Space Perception; Spiro Compounds; Task Performance and Analysis; Thiophenes; Treatment Outcome; Visual Perception | 2017 |
Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys.
Topics: Animals; Attention; Basal Nucleus of Meynert; Central Nervous System Stimulants; Cholinesterase Inhibitors; Deep Brain Stimulation; Donepezil; Macaca mulatta; Male; Mecamylamine; Methylphenidate; Muscarinic Antagonists; Neural Pathways; Nicotinic Antagonists; Scopolamine | 2018 |
SUVN-502, a novel, potent, pure, and orally active 5-HT6 receptor antagonist: pharmacological, behavioral, and neurochemical characterization.
Topics: Acetylcholine; Animals; Behavior, Animal; Brain; Brain Waves; CHO Cells; Cricetulus; Culture Media, Serum-Free; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Electroencephalography; Glutamic Acid; Indoles; Male; Maze Learning; Memantine; Memory Disorders; Microdialysis; Nootropic Agents; Piperazines; Rats; Rats, Wistar; Receptors, Serotonin; Recognition, Psychology; Scopolamine; Serotonin; Serotonin Antagonists | 2019 |
The location discrimination reversal task in mice is sensitive to deficits in performance caused by aging, pharmacological and other challenges.
Topics: Aging; Animals; Conditioning, Operant; Discrimination, Psychological; Dizocilpine Maleate; Donepezil; Inflammation; Lipopolysaccharides; Male; Mice; Rolipram; Scopolamine; Space Perception | 2018 |
Hypercholesterolemia impairs contextual fear conditioning memory formation in female mice: evidence for cholinergic dysfunction.
Topics: Acetylcholine; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Conditioning, Classical; Donepezil; Fear; Female; Hypercholesterolemia; Memory; Mice, Inbred C57BL; Mice, Knockout; Receptors, LDL; Scopolamine | 2018 |
Diosmin is neuroprotective in a rat model of scopolamine-induced cognitive impairment.
Topics: Animals; Cognitive Dysfunction; Diosmin; Disease Models, Animal; Donepezil; Hippocampus; Long-Term Potentiation; Male; Maze Learning; Memory; Neuroprotective Agents; Rats; Rats, Wistar; Scopolamine; Tumor Necrosis Factor-alpha | 2018 |
TAK-071, a muscarinic M1 receptor positive allosteric modulator, attenuates scopolamine-induced quantitative electroencephalogram power spectral changes in cynomolgus monkeys.
Topics: Allosteric Regulation; Alpha Rhythm; Animals; Delta Rhythm; Donepezil; Dose-Response Relationship, Drug; Electroencephalography; Macaca fascicularis; Muscarinic Agonists; Pyridines; Receptor, Muscarinic M1; Scopolamine; Theta Rhythm; Thiadiazoles | 2019 |
Studies of the Anti-amnesic Effects and Mechanisms of Single and Combined Use of Donepezil and Ginkgo Ketoester Tablet on Scopolamine-Induced Memory Impairment in Mice.
Topics: Acetylcholine; Acetylcholinesterase; Amnesia; Animals; Benzothiazoles; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Drug Therapy, Combination; Ginkgo biloba; Ginkgolides; Ligands; Malondialdehyde; Memory Disorders; Mice, Inbred ICR; Molecular Docking Simulation; Picrates; Plant Extracts; Receptor, trkB; Scopolamine; Sulfonic Acids; Superoxide Dismutase; Tablets | 2019 |
Reduced systemic exposure and brain uptake of donepezil in rats with scopolamine-induced cognitive impairment.
Topics: Animals; Brain; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Rats; Scopolamine | 2020 |
Design, synthesis, in vitro and in vivo evaluation of novel pyrrolizine-based compounds with potential activity as cholinesterase inhibitors and anti-Alzheimer's agents.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Kinetics; Ligands; Mice; Molecular Docking Simulation; Protein Aggregates; Protein Structure, Tertiary; Scopolamine; Structure-Activity Relationship | 2019 |
The effects and mechanisms of the action of galangin on spatial memory in rats.
Topics: Animals; Avoidance Learning; Cholinesterase Inhibitors; Donepezil; Flavonoids; Maze Learning; Mecamylamine; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine; Spatial Memory | 2019 |
Positive allosteric modulators of alpha 7 nicotinic acetylcholine receptors enhance procognitive effects of conventional anti-Alzheimer drugs in scopolamine-treated rats.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Cholinergic Antagonists; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Galantamine; Isoxazoles; Memantine; Nootropic Agents; Phenylurea Compounds; Rats; Recognition, Psychology; Scopolamine | 2020 |
Cognitive Facilitation and Antioxidant Effects of an Essential Oil Mix on Scopolamine-Induced Amnesia in Rats: Molecular Modeling of In Vitro and In Vivo Approaches.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior Rating Scale; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Gas Chromatography-Mass Spectrometry; Inhibitory Concentration 50; Limonene; Male; Memory Disorders; Molecular Docking Simulation; Oils, Volatile; Oxidative Stress; Rats; Rats, Wistar; Scopolamine | 2020 |
Dissociating cholinergic influence on alertness and temporal attention in primates in a simple reaction time paradigm.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Macaca mulatta; Male; Reaction Time; Scopolamine | 2020 |
Shaddock (
Topics: Acetylcholinesterase; Animals; Antioxidants; Butyrylcholinesterase; Cholinergic Agents; Citrus; Cognition; Donepezil; Maze Learning; Memory Disorders; Plant Extracts; Rats; Rats, Wistar; Reactive Oxygen Species; Scopolamine | 2022 |
Delay-dependent cholinergic modulation of visual short-term memory in rhesus macaques.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Dementia; Disease Models, Animal; Donepezil; Macaca mulatta; Male; Memory Disorders; Memory, Short-Term; Muscarinic Antagonists; Pattern Recognition, Visual; Psychomotor Performance; Scopolamine; Time Factors | 2021 |
Scopolamine and MK-801 impair recognition memory in a new spontaneous object exploration task in monkeys.
Topics: Acetylcholinesterase; Animals; Callithrix; Dizocilpine Maleate; Donepezil; Excitatory Amino Acid Antagonists; Female; Haplorhini; Male; Memory; Memory Disorders; Muscarinic Antagonists; Nootropic Agents; Open Field Test; Receptors, Muscarinic; Recognition, Psychology; Scopolamine | 2021 |
Effect of chlorogenic acid plus donepezil on critical neurocortical enzyme activities, inflammatory markers, and synaptophysin immunoreactivity in scopolamine-assaulted rats, supported by multiple ligand simultaneous docking.
Topics: Animals; Antioxidants; Butyrylcholinesterase; Chlorogenic Acid; Cholinesterase Inhibitors; Donepezil; Ligands; Monoamine Oxidase; Rats; Rats, Wistar; Scopolamine; Synaptophysin | 2022 |
Protective effects of isofraxidin against scopolamine-induced cognitive and memory impairments in mice involve modulation of the BDNF-CREB-ERK signaling pathway.
Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Cognition; Coumarins; Cyclic AMP Response Element-Binding Protein; Donepezil; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Maze Learning; Memory; Memory Disorders; Mice; Scopolamine; Signal Transduction | 2022 |
Insights of Valacyclovir in Treatment of Alzheimer's Disease: Computational Docking Studies and Scopolamine Rat Model.
Topics: Acetylcholinesterase; Acyclovir; Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antiviral Agents; Butyrylcholinesterase; Donepezil; Humans; Prodrugs; Rats; Scopolamine; Valacyclovir | 2022 |
Pharmaco-fUS in cognitive impairment: Lessons from a preclinical model.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cognitive Dysfunction; Donepezil; Humans; Indans; Mice; Piperidines; RNA-Binding Protein FUS; Scopolamine | 2022 |
Thymus daenensis extract prevents scopolamine‑induced memory impairment through declining oxidative stress in rats.
Topics: Animals; Antioxidants; Donepezil; Glutathione; Male; Malondialdehyde; Maze Learning; Memory Disorders; Neuroprotective Agents; Oxidative Stress; Plant Extracts; Rats; Rats, Wistar; Scopolamine | 2022 |
Aniba canelilla (Kunth) Mez essential oil and its primary constituent, 1-nitro-2-phenylethane, inhibits acetylcholinesterase and reverse memory impairment in rodents.
Topics: Acetylcholinesterase; Animals; Donepezil; Lauraceae; Maze Learning; Memory Disorders; Mice; Oils, Volatile; Rats; Rats, Wistar; Rodentia; Scopolamine | 2023 |
Therapeutic potential of blackberry extract in the preventing memory deficits and neurochemical alterations in the cerebral cortex, hippocampus and cerebellum of a rat model with amnesia.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Cerebellum; Cerebral Cortex; Donepezil; Hippocampus; Male; Maze Learning; Memory Disorders; Oxidative Stress; Rats; Rubus; Scopolamine | 2023 |
Hesperetin-loaded polymeric nanofibers: assessment of bioavailability and neuroprotective effect.
Topics: Acetylcholinesterase; Amnesia; Animals; Biological Availability; Donepezil; Maze Learning; Nanofibers; Neuroprotective Agents; Rats; Rats, Wistar; Scopolamine | 2023 |
Simultaneous Intranasal Codelivery of Donepezil and Memantine in a Nanocolloidal Carrier: Optimization, Pharmacokinetics, and Pharmacodynamics Studies.
Topics: Administration, Intranasal; Animals; Brain; Donepezil; Emulsions; Memantine; Mice; Nanoparticles; Particle Size; Scopolamine | 2023 |
Olax subscorpioidea prevented scopolamine-induced memory impairment through the prevention of oxido-inflammatory damage and modulation of cholinergic transmission.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinergic Agents; Donepezil; Hippocampus; Maze Learning; Memory Disorders; Mice; Neuroinflammatory Diseases; Nootropic Agents; Olacaceae; Oxidative Stress; Plant Extracts; Scopolamine | 2024 |