donepezil has been researched along with piperidines in 2202 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 173 (7.86) | 18.2507 |
| 2000's | 1103 (50.09) | 29.6817 |
| 2010's | 884 (40.15) | 24.3611 |
| 2020's | 42 (1.91) | 2.80 |
| Authors | Studies |
|---|---|
| Haginaka, J; Seyama, C | 1 |
| Iimura, Y; Sugimoto, H; Yamanishi, Y; Yamatsu, K | 1 |
| Asakawa, N; Matsui, K; Oda, Y; Ohe, H; Tanaka, S | 1 |
| Kozikowski, AP; Pang, YP | 1 |
| Fujii, T; Fujimoto, K; Kawashima, K; Sato, A; Suzuki, T; Yoshizawa, M | 1 |
| Benini, L; Cacciarelli, N; Galli, A; Mori, F | 1 |
| Dawson, GR; Iversen, SD | 1 |
| Hasegawa, J; Kamakura, H; Mihara, M; Morishita, N; Ohnishi, A; Tanaka, T; Tomono, Y; Yamazaki, K | 1 |
| Hasegawa, J; Mihara, M; Morishita, N; Ohnishi, A; Shimamura, Y; Tomono, Y; Yamazaki, K | 1 |
| Asakawa, N; Nochi, S; Sato, T | 1 |
| Giacobini, E; Sherman, KA; Williams, E; Zhu X, D | 1 |
| Braida, D; Griffini, P; Lamperti, M; Maggi, A; Paladini, E; Sala, M | 1 |
| Iimura, Y; Inoue, A; Kawai, T; Kawakami, Y; Sugimoto, H; Wakita, M | 1 |
| Hopfinger, AJ; Inoue, A; Kawai, T; Kawakami, Y; Sugimoto, H; Wakita, M | 1 |
| Palacios, JM | 1 |
| Nightingale, SL | 1 |
| Schneider, LS | 5 |
| Cheng, DH; Ren, H; Tang, XC | 1 |
| Fricker, J | 1 |
| Bailey, C | 1 |
| Benfield, P; Bryson, HM | 1 |
| Nichols, ME | 1 |
| Cayton, H; Harvey, RJ; Kelly, CA | 1 |
| Gray, S | 1 |
| Wagner, N | 1 |
| Ando, I; Kakiuchi, T; Ouchi, Y; Tsukada, H | 1 |
| Field, MJ; Rupniak, NM; Tye, SJ | 1 |
| Kojima, J; Nakajima, K; Nakayama, K; Ochiai, M | 1 |
| Geldmacher, DS | 3 |
| Anderson, R; Higgins, GA | 1 |
| Henry, RG; Wekstein, DR | 1 |
| Heath, ML | 2 |
| Hastie, I; Robertson, M; Roscoe, T | 1 |
| Shintani, EY; Uchida, KM | 1 |
| Ross, JS; Shua-Haim, JR | 1 |
| Greenhalgh, T | 1 |
| Best, L; Milne, R; Stein, K | 1 |
| Boothby, H; Jameel, H; Khalaf, S; Mahomed, S; Seth, V; Zaidi, SM | 1 |
| Jones, RW; Mann, JB; Saunders, SA | 1 |
| Wilkinson, D | 2 |
| Doody, RS; Farlow, MR; Friedhoff, LT; Mohs, R; Rogers, SL | 1 |
| Friedhoff, LT; Rogers, SL | 2 |
| Eisner, E | 1 |
| Barner, EL; Gray, SL | 1 |
| Lichtman, SW; Seliger, G; Taverni, JP | 1 |
| Royston, MC; Shah, A | 1 |
| Poorheidari, G; Pratt, JA; Stanhope, KJ | 1 |
| Honma, A | 1 |
| Melzer, D | 1 |
| Kendall, MJ; Misson, J | 1 |
| Collier, J | 1 |
| Cole, MG; Elie, LM | 1 |
| Cummings, JL; Tom, T | 1 |
| Braida, D; Colibretti, L; Griffini, P; Lamperti, M; Paladini, E; Sala, M | 1 |
| Larson, EB | 1 |
| Doody, RS; Friedhoff, LT; Mohs, RC; Rogers, SL | 1 |
| Sparano, N | 1 |
| Ancill, RJ; Geizer, M | 1 |
| Post, SG | 1 |
| Bourke, D; Druckenbrod, RW | 1 |
| Post, SG; Whitehouse, PJ | 1 |
| Nordberg, A; Svensson, AL | 1 |
| Cheng, DH; Tang, XC | 1 |
| Tang, XC; Wang, T | 1 |
| Dempsey, G; Phillips, R; Stewart, A | 1 |
| Grossberg, GT; Lake, JT | 1 |
| Peskind, ER | 1 |
| Bryant, CA; Jackson, SH; Kinirons, MT; Ouldred, E | 1 |
| Dening, T; Lawton, C | 1 |
| Hodges, J | 1 |
| Burke, WJ; Keller, BK; Magnuson, TM | 1 |
| Cummings, JL | 4 |
| Sunderland, T; Tune, LE | 1 |
| Carey, JE; Frey, KA; Kilbourn, MR; Kuhl, DE; Mulholland, GK; Sherman, PS; Wieland, DM | 1 |
| Hier, DB; Pavel, D; Warren, S | 1 |
| MacKnight, C; Rockwood, K; Shea, C | 1 |
| Castellani, WJ; Sprung, J; Srinivasan, V; Udayashankar, S | 1 |
| Bouman, WP; Pinner, G | 1 |
| Bayer, BL; Burke, WJ; Knop, D; McNeilly, DP; Roccaforte, WH; Wengel, SP | 1 |
| Hu, GY; Lin, JH; Tang, XC | 2 |
| Catt, KE; DeKosky, ST; Kaufer, DI; Lopez, OL | 1 |
| Karlawish, JH; Whitehouse, PJ | 1 |
| Cooper, NM; Friedhoff, LT; Lee, JN; Pederson, JE; Rogers, SL; Sukovaty, R | 1 |
| Friedhoff, LT; Rogers, SL; Tiseo, PJ | 1 |
| Friedhoff, LT; Perdomo, CA; Tiseo, PJ | 4 |
| Foley, K; Friedhoff, LT; Tiseo, PJ | 3 |
| Friedhoff, LT; Perdomo, CA; Tiseo, PJ; Vargas, R | 1 |
| Levy, R | 1 |
| Evans, M | 1 |
| Baxter, T; Black, D; Prempeh, H | 1 |
| Watson, JP; Wise, ME; Zamar, AC | 1 |
| Benazzi, F | 2 |
| Rogers, SL | 1 |
| Lacomblez, L | 1 |
| Doody, RS | 5 |
| Bhattacharjya, A; Brod, M; Brodaty, H; Dor, A; Feldman, H; Forette, F; Gauthier, S; Hay, J; Henke, C; Hill, S; Mastey, V; Neumann, P; O'Brien, B; Pugner, K; Sano, M; Sawada, T; Shostak, D; Stone, R; Whitehouse, PJ; Wimo, A; Winblad, B | 1 |
| Derquesné, C | 1 |
| Burke, WJ; Roccaforte, WH; Wengel, SP | 3 |
| van Gool, WA | 1 |
| Larson, EB; Shadlen, MF | 1 |
| Terpstra, T | 1 |
| Hecker, J | 1 |
| Aarsland, D; Brønnick, K; Karlsen, K | 1 |
| Iimura, Y; Ogura, H; Sugimoto, H; Yamanishi, Y; Yamatsu, K | 1 |
| Greene, YM; Noviasky, J; Tariot, PN | 1 |
| Babic, T; Zurak, N | 1 |
| Cross, AJ; De Souza, RJ; Green, AR; Misra, A; Murray, TK; Snape, MF; Williams, JL | 1 |
| Doraiswamy, PM; Kishnani, PS; Krishnan, KR; Spiridigliozzi, GA; Sullivan, JA; Walter, BK | 1 |
| Mushlin, AI | 1 |
| Araki, SS; Berenbaum, PA; Duff, SB; Goldman, PA; Hermann, RC; Kuntz, KM; Leon, J; Neumann, PJ; Weinstein, MC; Williams, LW | 1 |
| Jelly, DM; Tapsfield, WG | 1 |
| Holmes, D; Matthews, H; Wilkinson, D | 1 |
| Glazier, RH; Steele, LS | 1 |
| Blackhouse, G; Gagnon, M; Gauthier, S; Goeree, R; Hux, M; Iskedjian, M; O'Brien, BJ | 1 |
| Tiseo, P | 1 |
| Mendez, MF; Perryman, KM; Younesi, FL | 1 |
| Kryger, G; Silman, I; Sussman, JL | 1 |
| Pryse-Phillips, W | 1 |
| Tang, XC; Wang, H | 1 |
| Burt, T; Demopulos, C; Sachs, GS | 1 |
| Benazzi, F; Rossi, E | 1 |
| Whitlock, JA | 1 |
| Matsui, K; Nakata, H; Oda, Y; Yoshimura, T | 1 |
| Dom, R; Lemière, J; Van Gool, D | 1 |
| Hoopes, SP | 1 |
| Carrier, L | 1 |
| Trabucchi, M | 1 |
| Doraiswamy, PM; McLendon, BM | 1 |
| Garcia, A | 1 |
| Jönsson, B; Jönsson, L; Lindgren, P; Wimo, A; Winblad, B | 1 |
| Hemingway-Eltomey, JM; Lerner, AJ | 1 |
| Warner, JP | 1 |
| Kosasa, T; Kuriya, Y; Matsui, K; Yamanishi, Y | 3 |
| Booker, JG; Nave, DW; Patrick, G; Reeves, RR; Struve, FA | 1 |
| Charlesworth, G; Shepstone, L | 1 |
| Foster, RH; Plosker, GL | 1 |
| Comas-Díaz, L; Jacobsen, FM | 1 |
| Barclay, TR; Cummings, JL; Masterman, DM; Mega, MS; O'Connor, SM | 1 |
| Benbow, S; Jolley, D; Jones, R | 1 |
| Burke, JR; Morgenlander, JC | 1 |
| Matsui, K; Mishima, M; Nagai, Y; Yoshimura, T; Yuzuriha, T | 1 |
| Kosasa, T; Kuriya, Y; Yamanishi, Y | 1 |
| Matsui, K; Taniguchi, S; Yoshimura, T | 1 |
| Bertogliati, C; Gokalsing, E; Robert, PH | 1 |
| Babic, T | 1 |
| Chen, K; Ji, R; Jiang, H; Zeng, F; Zhai, Y; Zhang, H | 1 |
| Burns, A; Page, S; Russell, E | 1 |
| Beason-Hazen, S; Fernandez, HH; Friedman, JH; Grace, J | 1 |
| Brown, LB; Corwin, C; Daffner, KR; Friedman, P; Gomez-Isla, T; Greenberg, SM; Growdon, JH; Hayden, DL; Meadows, ME; Schoenfeld, DA; Sperling, RA; Tennis, MK; Walsh, KL | 1 |
| Kaur, J; Zhang, MQ | 1 |
| Iimura, Y; Kawakami, Y; Sugimoto, H; Yamanishi, Y | 1 |
| Chowdhury, T; Ellis, A; Evans, M; Watson, D | 1 |
| Fillit, H; Gutterman, EM; Lewis, B | 1 |
| Koellner, G; Kryger, G; Millard, CB; Silman, I; Steiner, T; Sussman, JL | 1 |
| Mumenthaler, MS; O'Hara, R; Yesavage, JA | 1 |
| Buffa, C; Dallocchio, C; Mazzarello, P | 1 |
| Kakiuchi, T; Nishiyama, S; Sato, K; Tsukada, H | 1 |
| Fergusson, E; Howard, R | 1 |
| Gemmell, HG; Murray, AD; Shanks, MF; Staff, RT; Venneri, A | 1 |
| Danysz, W; Moebius, HJ; Quack, G; Wenk, GL | 1 |
| Beare, CH; Buckley, NA | 1 |
| Cummings, J; Fillit, H | 1 |
| Herrmann, N; Lanctôt, KL | 1 |
| Beyreuther, K; Emilien, G; Maloteaux, JM; Masters, CL | 1 |
| Kosasa, T; Ogura, H; Yamanishi, Y | 1 |
| Horn, N; Watts-Tobin, MA | 1 |
| Doody, RS; Ieni, JR; Pratt, RD; Rogers, SL | 1 |
| Birks J, S; Melzer, D | 1 |
| Alagiakrishnan, K; Blanchette, PL; Wong, W | 1 |
| Dooley, M; Lamb, HM | 1 |
| Brooks, RL; Cummings, JL; Donohue, JA | 1 |
| Aupperle, PM; Coyne, AC | 1 |
| Rojas-Fernandez, C | 1 |
| Braida, D; Ottonello, F; Sala, M; Virag, W | 1 |
| Fotiou, F; Fountoulakis, KN; Goulas, A; Palikaras, A; Tsolaki, M | 1 |
| Cox, C; Greene, YM; Holt, CJ; Noviasky, J; Schwid, S; Tariot, PN; Wishart, H | 1 |
| Egido, A; Gutiérrez, L; Lechuga, I; Sena, F | 1 |
| Kosasa, T; Kuriya, Y; Ogura, H; Yamanishi, Y | 3 |
| Alt, M; Carcenac, D; Demuynck-Roegel, C; Kiesmann, M; Kuntzmann, F; Martin-Hunyadi, C | 1 |
| Araki, S; Kosasa, T; Ogura, H; Yamanishi, Y | 1 |
| Baik, J; Han, IW; Koo, MS; Kwak, YT | 1 |
| Collinson, S; Terao, T | 1 |
| Barnes, CA; Houston, F; McGann, K; Meltzer, J; Orr, G; Wenk, GL | 1 |
| Fontaine, CS; Foster, BM; Martin-Cook, K; Saine, K; Svetlik, DA; Weiner, MF | 1 |
| Hashimoto, M; Imamura, T; Kazui, H; Mori, E; Tanimukai, S | 1 |
| Korbey, J; Matthews, HP; Rowden, J; Wilkinson, DG | 1 |
| Foster, NL; Frey, KA; Kilbourn, MR; Koeppe, RA; Kuhl, DE; Minoshima, S | 1 |
| Schultz, SK; Walker, MS; Whelan, FJ | 1 |
| Caligiuri, M; Galasko, D; Jeste, DV; Lacro, J; Marini, M; McClure, FS; Samuel, W; Warren, K | 1 |
| Deleu, D; Hanssens, Y | 1 |
| Ringman, JM; Simmons, JH | 1 |
| Araki, SS; Gazelle, GS; Harris, GJ; McMahon, PM; Neumann, PJ | 1 |
| Arai, M | 1 |
| Cameron, I; Curran, S; Newton, P; Petty, D; Wattis, J | 1 |
| Biederman, J; Prince, JB; Spencer, TJ; Wilens, TE; Wong, J | 1 |
| Kasa, P; Papp, H; Torok, I | 1 |
| Stahl, SM | 2 |
| Brooks, RL; Fillit, HM; Gutterman, EM | 1 |
| Amouyal-Barkate, K; Bagheri-Charabiani, H; Montastruc, JL; Moulias, S; Vellas, B | 1 |
| Dronfield, S; Egan, K; Green, AR; Marsden, CA | 1 |
| Gray, R; Yorston, GA | 1 |
| Burt, T | 1 |
| Nace, DA; Towers, AL; Verrico, MM | 1 |
| Doraiswamy, PM; Heller, JH; Kishnani, PS; Krishnan, KR; Spiridigliozzi, GA; Sullivan, JA | 1 |
| Choe, YS; Choi, Y; Hwang, SH; Kim, B; Kim, SE; Lee, J; Lee, K; Lee, SY; Sugimoto, H | 1 |
| De Vos , F; Dewolf, I; Dierckx, RA; Dumont, F; Santens, P; Slegers, G; Vermeirsch, H | 1 |
| Aotsuka, A; Fukushi, K; Irie, T; Nagatsuka, S; Ota, T; Shinotoh, H; Tanada, S; Tanaka, N | 1 |
| Nygaard, HA; Skjerve, A | 1 |
| Allington, M; Salib, E | 1 |
| Earl-Slater, A; Walley, T | 1 |
| Giacobini, E | 1 |
| Kashiwagi, Y; Kudo, T; Nakamura, Y; Nishikawa, T; Shinosaki, K; Takeda, M; Tanaka, T | 1 |
| Compton, SA; McGirr, G | 1 |
| Dunn, NR; Pearce, GL; Shakir, SA | 1 |
| Nakamura, S | 1 |
| Rojas-Fernandez, CH | 1 |
| Grutzendler, J; Morris, JC | 1 |
| Andreasen, N; Blennow, K; Davidsson, P; Eriksson, B; Hesse, C; Minthon, L | 1 |
| Heuser, I; Leins, ML; Schredl, M; Weber, B | 1 |
| Barbanti, P; Bonifati, V; Colosimo, C; Fabbrini, G; Gasparini, M; Meco, G; Vanacore, N | 1 |
| Campbell, EC; Caroff, SN; Havey, JC; Katz, IR; Mann, SC; Sullivan, KA | 1 |
| Andrisano, V; Cavrini, V; Gotti, R; Pomponio, R | 1 |
| Wilkinson, DG | 1 |
| Doody, RS; Geldmacher, DS; Gordon, B; Perdomo, CA; Pratt, RD | 1 |
| Borroni, B; Cattabeni, F; Colciaghi, F; Cottini, E; Di Luca, M; Lenzi, GL; Monastero, R; Padovani, A; Pastorino, L; Pettenati, C; Rozzini, L | 1 |
| Bryant, J; Clegg, A; De Broe, S; Gerard, K; McIntyre, L; Nicholson, T; Waugh, N | 2 |
| Angunawela, II; Barker, A | 1 |
| Devi, G; Silver, J | 1 |
| Hirai, S | 1 |
| Christie, S; DeVane, CL; George, MS; Gilliard, C; Horner, MD; Markowitz, JS; McGurk, S; Mintzer, J; Molloy, M; Nahas, Z; Owens, SD; Risch, SC | 1 |
| Araki, S; Claxton, K; Neumann, PJ; Weinstein, MC | 1 |
| Horrigan, JP | 1 |
| Bolton, TM; Rhiner, M; Slatkin, NE | 1 |
| Contreras, JM; Parrot, I; Rival, YM; Sippl, W; Wermuth, CG | 1 |
| Farlow, MR | 5 |
| Dunbar, F; Rasmusen, L; Robillard, A; Yan, B | 1 |
| Maelicke, A | 1 |
| Fu, Y; Tang, XC; Zhou, J | 1 |
| Bayley, MT; Masanic, CA; Simard, M; VanReekum, R | 1 |
| Hutchison, CW; Mrazek, L; Nathan, PJ; Stough, C | 1 |
| Hake, AM | 1 |
| Doyle, Y | 1 |
| Klein, HE; Marienhagen, J; Spiessl, H; Stöhr, H | 1 |
| Horiguchi, J; Inagaki, T; Itoga, M; Miyaoka, T; Seno, H; Tsubouchi, K; Yamamori, C | 1 |
| Grafman, J; Hallett, M; Litvan, I; Pharr, VL; Phipps, M; Salazar, A | 1 |
| Doody, RS; Ieni, JR; Mohs, RC; Morris, JC; Perdomo, CA; Pratt, RD; Rogers, SL | 1 |
| Engedal, K; Haglund, A; Soininen, H; Subbiah, P; Verhey, F; Waldemar, G; Wetterholm, AL; Wimo, A; Winblad, B; Zhang, R | 1 |
| Lampley-Dallas, VT | 1 |
| Duttagupta, S; Fillit, HM; Knopman, DS; Lloyd, JR; Max, W; Rice, DP | 1 |
| Gavrilova, SI; Zharikov, GA | 1 |
| Feldman, H; Gauthier, S; Hecker, J; Subbiah, P; Vellas, B; Whalen, E | 1 |
| Slagle, MA | 1 |
| Asada, T; Matsuda, H; Nakano, S; Takasaki, M; Uno, M | 1 |
| Archetti, S; Borroni, B; Caimi, L; Cattabeni, F; Colciaghi, F; Cottini, E; Di Luca, M; Padovani, A; Pastorino, L | 1 |
| Amici, S; Antognelli, C; Gallai, V; Lanari, A; Parnetti, L; Romani, R | 1 |
| Winblad, B | 1 |
| Sternon, J; Ventura, M | 1 |
| Farrú, R; Palacios, M; Pappa, H; Pizzorno, MT; Vilanova, PO | 1 |
| Andreani, A; Cavalli, A; Granaiola, M; Guardigli, M; Leoni, A; Locatelli, A; Morigi, R; Rambaldi, M; Recanatini, M; Roda, A | 1 |
| Macdonald, AJ | 1 |
| Kogan, EA; Korczyn, AD; Neufeld, MY; Treves, TA; Virchovsky, RG | 1 |
| Ikeda, S; Ikegami, N; Yamada, Y | 1 |
| Cruz-Reina, MM; Fajardo-Tibau, C; Garre-Olmo, J; Hernàndez-Ferràndiz, M; López-Pousa, S; Lozano-Gallego, M; Turon-Estrada, A; Vilalta-Franch, J | 1 |
| Iwado, H; Morita, Y; Shinjo, H; Ueki, A | 1 |
| Ehmann, TS; Khanbhai, I; MacEwan, GW; Wrixon, C | 1 |
| Gasser, T; Schreiter Gasser, U | 1 |
| Arahata, H; Furuya, H; Kira, J; Kuwabara, Y; Matsumoto, S; Murai, H; Nakagawa, M; Ohyagi, Y; Yamada, T | 1 |
| Chowdhury, MH; Haque, MA; Hinh, P; Li, Y; Meyer, JS; Quach, M | 1 |
| Schwam, EM; Subbiah, P | 1 |
| Abe, K; Hanyu, H; Sakurai, H; Takasaki, M; Tanaka, Y | 2 |
| Campbell, EC; Caroff, SN; Gallop, R; Havey, J; Mann, SC; Sullivan, KA | 1 |
| Bogetto, F; Cocuzza, E; Marchiaro, L; Rocca, P | 1 |
| Gasser, T; Gasser, US | 1 |
| Homma, A; Shigeta, M | 1 |
| Cummings, JL; Katz, IR; Mintzer, J; Perdomo, CA; Schwam, EM; Tariot, PN; Whalen, E | 1 |
| Bharucha, A; Chew, ML; Huber, KA; Jacob, NJ; Kastango, KB; Marin, R; Mazumdar, S; Mulsant, BH; Pollock, BG; Rosen, J; Sweet, RA | 1 |
| Higashi, M; Kawashima, S; Matsuno, T; Yamaguchi, Y | 1 |
| Furuya, R; Takahata, T; Tateishi, T; Yasui-Furukori, N | 1 |
| Deleu, D | 1 |
| Sugimoto, H | 3 |
| Adler, DN; Brenner, G; Davis, KL; Friedman, JI; Harvey, PD; Howanitz, E; Parrella, M; Temporini, H; White, L | 1 |
| Bar, F; Baruch, Y; Rabey, JM; Strous, RD; Stryjer, R | 1 |
| Haque, MS; Huxley, A; Prasher, VP | 1 |
| Bullock, R; Connolly, C | 1 |
| Andrews, PJ; Giles, DE; Gillin, JC; Orff, HJ; Perlis, ML; Smith, MT | 1 |
| Fillit, H; Futterman, R; Hill, JW; Mastey, V | 1 |
| Kawashima, T; Yamada, S | 1 |
| Hasegawa, H; Ishikawa, M; Isoma, K; Kamei, J; Kohda, T; Ogawa, Y; Ohta, M | 1 |
| Chen, Z; Li, R; Wei, EQ; Xu, AJ | 1 |
| Allain, H; Bentue-Ferrer, D; Lecavorzin, P; Polard, E; Reymann, JM; Tribut, O | 1 |
| Putt, ME; Ravina, B | 1 |
| Asakawa, N; Ishihama, Y; Kajima, T; Miwa, T; Nakamura, M | 1 |
| Almeida, OP; Coulson, BS; Fenner, SG | 1 |
| Lam, W | 1 |
| Klein, C; Rabey, JM; Werber, AE | 1 |
| Archetti, S; Borroni, B; Cattabeni, F; Colciaghi, F; Corsini, P; Di Luca, M; Padovani, A; Pastorino, L | 1 |
| Aarsland, D; Janvin, C; Laake, K; Larsen, JP | 1 |
| Patrick, G; Reeves, RR; Struve, FA | 1 |
| Anderson, MJ; Roe, CM; Spivack, B | 1 |
| Garrido Barral, A; González Moneo, MJ | 1 |
| Abe, M; Aizawa, R; Kanbayashi, T; Kaneko, Y; Kitajima, T; Ogawa, Y; Saito, Y; Shimizu, T; Sugiyama, T | 1 |
| Kamata, K; Nishijima, T; Sano, M; Suwata, J; Yoshikawa, T | 1 |
| Enderlin, M; Fimbel, R; Gill, R; Grottick, AJ; Haman, M; Higgins, GA; Kemp, JA; Richards, JG; Soriano, M | 1 |
| Arai, Y; Limura, Y; Ogura, H; Sugimoto, H; Yamanishi, Y | 1 |
| Cherry, D; Cummings, JL; Frank, JC; Hewett, L; Kemp, B; Kohatsu, ND; Mittman, B | 1 |
| Auriacombe, S; Loria-Kanza, Y; Pere, JJ; Vellas, B | 1 |
| Robert, P | 1 |
| Friedman, L; Mumenthaler, MS; O'Hara, R; Sheikh, J; Taylor, JL; Tinklenberg, J; Whitehouse, PJ; Yesavage, JA | 1 |
| Blount, PJ; McDeavitt, JT; Nguyen, CD | 1 |
| Lin, SK; Liu, HC; Sung, SM | 1 |
| Bellucci, A; Casamenti, F; Costagli, C; Pepeu, G; Scali, C; Schmidt, B | 1 |
| Aurilia, C; Barbanti, P; Fabbrini, G; Lenzi, GL; Meco, G; Pauletti, C | 1 |
| Bencherif, B; Dannals, RF; Endres, CJ; Frost, JJ; Hilton, J; Musachio, JL; Scheffel, U; Villalobos, A; Williams, S | 1 |
| Demers, L; Momoli, F; Moride, Y; Oremus, M; Perrault, A; Shukla, V; Wolfson, C | 1 |
| Doran, E; Lott, IT; Nelson, L; Osann, K | 1 |
| Burns, A; Byrne, EJ; Maurer, K | 1 |
| Rösler, M | 1 |
| Inglis, F | 1 |
| Canfora, M; De Leo, C; Girtler, N; Mariani, G; Nobili, F; Pupi, A; Rodriguez, G; Vitali, P | 1 |
| Couderc, R; Forette, F; Latour, F; Moulin, F; Rigaud, AS; Traykov, L | 1 |
| Grimley Evans, J; Price, JD | 1 |
| Matsuoka, N; Mutoh, S; Tokita, K; Yamazaki, M; Yamazaki, S | 1 |
| Jann, MW; Shirley, KL; Small, GW | 1 |
| Darcourt, J; Ebmeier, K; Koulibaly, M; Mariani, G; Migneco, O; Nobili, F; Pupi, A; Robert, PH; Rodriguez, G; Vitali, P | 1 |
| Marder, K | 3 |
| Ott, BR | 1 |
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342 review(s) available for donepezil and piperidines
| Article | Year |
|---|---|
New therapeutic approaches to Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Carbamates; Cholinergic Agents; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon | 1996 |
Donepezil.
Topics: Aged; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Rats | 1997 |
Dementia in the elderly.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Piperidines; Tacrine; United States | 1997 |
Providing dental care for patients diagnosed with Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Caregivers; Cholinesterase Inhibitors; Dental Care for Chronically Ill; Dentist-Patient Relations; Donepezil; Family Relations; Humans; Indans; Middle Aged; Nootropic Agents; Oral Hygiene; Piperidines; Prevalence; Professional-Family Relations; Tacrine | 1997 |
Donepezil: an anticholinesterase inhibitor for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anorexia; Cholinesterase Inhibitors; Diarrhea; Donepezil; Drug Administration Schedule; Drug Interactions; Humans; Indans; Nausea; Piperidines | 1997 |
Preparing yourself. Visiting loved ones with Alzheimer's disease.
Topics: Adaptation, Psychological; Adult; Aged; Alzheimer Disease; Child; Cholinesterase Inhibitors; Donepezil; Family; Humans; Indans; Piperidines; Visitors to Patients | 1997 |
Donepezil use in Alzheimer disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 1998 |
Donezepil for dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Drug Monitoring; Humans; Indans; Informed Consent; Piperidines | 1997 |
Donepezil for Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Patient Selection; Piperidines; Randomized Controlled Trials as Topic | 1997 |
[Therapeutic agents for Alzheimer's disease].
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Monoamine Oxidase Inhibitors; Neuropeptides; Phenylcarbamates; Piperidines; Receptor, Muscarinic M1; Receptors, Muscarinic; Rivastigmine; Spiro Compounds; Tacrine | 1998 |
New drug treatment for Alzheimer's disease: lessons for healthcare policy.
Topics: Advertising; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Decision Making; Donepezil; Drug Approval; Drug Industry; Editorial Policies; Evidence-Based Medicine; Government Regulation; Health Policy; Humans; Indans; Information Dissemination; Piperidines; Risk Assessment; Therapeutic Human Experimentation; United Kingdom; United States | 1998 |
Therapeutic advances: donepezil for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Contraindications; Donepezil; Drug Interactions; Drug Monitoring; Humans; Indans; Neurons, Afferent; Piperidines; United Kingdom | 1997 |
The fear of forgetfulness: a grassroots approach to an ethics of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Ethics, Medical; Female; Humans; Indans; Male; Memory Disorders; Personal Autonomy; Personhood; Physician-Patient Relations; Piperidines; Quality of Life; Risk Assessment; Self Concept; Truth Disclosure; Value of Life; Withholding Treatment | 1998 |
Pharmacotherapy for people with Alzheimer's disease: a Markov-cycle evaluation of five years' therapy using donepezil.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Cost-Benefit Analysis; Disease Progression; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Markov Chains; Models, Economic; Models, Neurological; Models, Psychological; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome; United Kingdom | 1998 |
The role of the psychiatrist in Alzheimer's disease.
Topics: Alzheimer Disease; Attitude to Health; Caregivers; Donepezil; Drug Therapy, Combination; Family Health; Forensic Psychiatry; Humans; Indans; Nootropic Agents; Patient Care Team; Physician's Role; Piperidines; Psychiatric Status Rating Scales; Psychiatry | 1998 |
Pharmacologic approaches to cognitive deficits in Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Nootropic Agents; Piperidines; Placebos; Tacrine; Treatment Outcome; Trichlorfon | 1998 |
New therapeutic approaches to cognitive impairment.
Topics: Aged; Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Humans; Indans; Monoamine Oxidase Inhibitors; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon | 1998 |
New cholinergic therapies: treatment tools for the psychiatrist.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens; Female; Humans; Indans; Male; Piperidines; Selective Serotonin Reuptake Inhibitors; Selegiline; Tacrine; Vitamin E | 1998 |
Is the placebo control obsolete in a world after donepezil and vitamin E?
Topics: Cognition Disorders; Control Groups; Controlled Clinical Trials as Topic; Donepezil; Ethics Committees, Research; Ethics, Medical; Federal Government; Government Regulation; Humans; Indans; Piperidines; Placebos; Research Design; Research Subjects; Risk Assessment; Therapeutic Human Experimentation; Vitamin E | 1998 |
Perspectives in the management of Alzheimer's disease: clinical profile of donepezil.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Donepezil; Double-Blind Method; Humans; Indans; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic | 1998 |
Clinical profile of donepezil in the treatment of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials, Phase III as Topic; Cognition; Donepezil; Drug Tolerance; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 1999 |
Donepezil update.
Topics: Aged; Alzheimer Disease; Donepezil; Follow-Up Studies; Humans; Indans; Middle Aged; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 1998 |
What's new in Alzheimer's disease treatment? Reasons for optimism about future pharmacologic options.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines; Tacrine | 1999 |
Alzheimer's disease: the advent of effective therapy.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Diagnostic Imaging; Donepezil; Female; Humans; Indans; Male; Piperidines; Risk Factors; Tacrine | 1998 |
[Discovery and development of donepezil hydrochloride for the treatment of Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Design; Humans; Indans; Piperidines; Rats; Receptors, Cholinergic; Structure-Activity Relationship | 1999 |
Rational design of anti-dementia therapy.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia; Donepezil; Drug Design; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Clinical benefits of a new piperidine-class AChE inhibitor.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Synaptic Transmission | 1999 |
Do we have drugs for dementia? No.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Ginkgo biloba; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Piperidines; Plants, Medicinal; Selegiline; Tacrine; Vitamin E | 1999 |
Treatment of Alzheimer's disease: an evaluation of the cholinergic approach.
Topics: Acetylcholine; Alzheimer Disease; Animals; Carbamates; Chemical and Drug Induced Liver Injury; Cholinergic Agents; Cholinergic Fibers; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Double-Blind Method; Drug Evaluation, Preclinical; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Receptors, Cholinergic; Receptors, Muscarinic; Receptors, Nicotinic; Rivastigmine; Tacrine | 1999 |
An economic perspective on Alzheimer's disease.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Combined Modality Therapy; Cost of Illness; Costs and Cost Analysis; Donepezil; Humans; Indans; Institutionalization; Italy; Mental Health Services; Neuropsychological Tests; Piperidines; Reality Therapy; Tacrine | 1999 |
Defining meaningful change in Alzheimer's disease trials: the donepezil experience.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Dose-Response Relationship, Drug; Guidelines as Topic; Humans; Indans; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 1999 |
Donepezil. Pharmacoeconomic implications of therapy.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Costs and Cost Analysis; Donepezil; Drug Evaluation; Economics, Pharmaceutical; Humans; Indans; Markov Chains; New Zealand; Nootropic Agents; Piperidines | 1999 |
Update on Alzheimer's disease. Promising advances in detection and treatment.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Donepezil; Estrogen Replacement Therapy; Estrogens; Female; Humans; Indans; Piperidines; Vitamin E | 1999 |
Therapeutic standards in Alzheimer disease.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Humans; Indans; Piperidines; Quality of Health Care; Quality of Life; Treatment Outcome; Vitamin E | 1999 |
Molecular modelling and QSAR of reversible acetylcholines-terase inhibitors.
Topics: Alkaloids; Alzheimer Disease; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Glaucoma; Humans; Indans; Models, Molecular; Myasthenia Gravis; Neostigmine; Physostigmine; Piperidines; Sesquiterpenes; Structure-Activity Relationship; Surface Properties; Tacrine | 2000 |
Donepezil hydrochloride (E2020) and other acetylcholinesterase inhibitors.
Topics: Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Rats; Stereoisomerism; Structure-Activity Relationship | 2000 |
Prospects for pharmacological intervention in Alzheimer disease.
Topics: Alzheimer Disease; Amyloid Precursor Protein Secretases; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Aspartic Acid Endopeptidases; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Endopeptidases; Hippocampus; Humans; Indans; N-Methylaspartate; Nerve Growth Factors; Nicotine; Piperidines; Tacrine | 2000 |
[Development of donepezil hydrochloride (Aricept) for the treatment of Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Design; Drug Evaluation, Preclinical; Humans; Indans; Nootropic Agents; Piperidines | 2000 |
Donepezil for mild and moderate Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Piperidines | 2000 |
Donepezil: a review of its use in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Donepezil; Humans; Indans; Piperidines | 2000 |
[Pharmacological properties of donepezil hydrochloride (Aricept), a drug for Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Learning Disabilities; Piperidines | 2000 |
Donepezil and related cholinesterase inhibitors as mood and behavioral controlling agents.
Topics: Affect; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Mental Disorders; Piperidines | 2000 |
Cholinesterase inhibitors stabilize Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Trichlorfon | 2000 |
[Current status of the treatment of Alzheimer's disease].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2000 |
Cholinesterase inhibitors for Alzheimer's disease.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cost-Benefit Analysis; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
The pharmacology of donepezil: a new treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Interactions; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Clinical and cost-effectiveness of donepezil, rivastigmine and galantamine for Alzheimer's disease: a rapid and systematic review.
Topics: Alzheimer Disease; Carbamates; Cost-Benefit Analysis; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2001 |
Approaches to memory loss in neuropsychiatric disorders.
Topics: Aging; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Dementia; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Memory Disorders; Nootropic Agents; Piperidines; Premenopause; Randomized Controlled Trials as Topic; Tacrine | 2000 |
[Recent development of anti-dementia drugs].
Topics: Acetylcholinesterase; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Donepezil; Free Radical Scavengers; Humans; Indans; Nerve Growth Factor; Piperidines | 2001 |
Present and future pharmacotherapeutic options for adult attention deficit/hyperactivity disorder.
Topics: Adult; Amphetamines; Antidepressive Agents; Attention Deficit Disorder with Hyperactivity; Central Nervous System Stimulants; Donepezil; Dopamine Plasma Membrane Transport Proteins; Humans; Indans; Isoxazoles; Membrane Glycoproteins; Membrane Transport Proteins; Methylphenidate; Nerve Tissue Proteins; Piperidines; Pyrrolidines | 2001 |
Use of cholinesterase inhibitors for treatment of Alzheimer disease.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
Prevalence, costs, and treatment of Alzheimer's disease and related dementia: a managed care perspective.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Cost of Illness; Donepezil; Female; Humans; Indans; Male; Managed Care Programs; Medicaid; Nootropic Agents; Piperidines; Prevalence; United States | 2001 |
[Current strategies of pathogenetic therapy of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Amino Acids; Aminoquinolines; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Estrogens; Ginkgo biloba; Humans; Indans; Memantine; Monoamine Oxidase Inhibitors; Multicenter Studies as Topic; Neuronal Plasticity; Neuroprotective Agents; Neurotransmitter Agents; Nicergoline; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Piracetam; Pyrithioxin; Rivastigmine; Selegiline; Tacrine; Time Factors | 2001 |
Platelet amyloid precursor protein forms in AD: a peripheral diagnostic tool and a pharmacological target.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Biomarkers; Blood Platelets; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2001 |
[Anticholinesterase agents in Alzheimer's disease].
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Carbamates; Cholinesterase Inhibitors; Diagnosis, Differential; Disease Progression; Donepezil; Drug Therapy, Combination; Estrogen Replacement Therapy; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Treatment Outcome | 2001 |
[A comparison of cholinesterase inhibitors and ginkgo extract in treatment of Alzheimer dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Ginkgo biloba; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Phytotherapy; Piperidines; Plant Extracts; Randomized Controlled Trials as Topic; Rivastigmine; Trichlorfon | 2001 |
Donepezil for Alzheimer's disease: pharmacodynamic, pharmacokinetic, and clinical profiles.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials, Phase III as Topic; Donepezil; Humans; Indans; Piperidines; Quality of Life; Randomized Controlled Trials as Topic | 2001 |
Donepezil hydrochloride: a treatment drug for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Structure-Activity Relationship | 2001 |
[Perspectives for drug treatment in Alzheimer's disease].
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
Successful treatment of behavioural problems in dementia using a cholinesterase inhibitor: the ethical questions.
Topics: Aged; Aged, 80 and over; Australia; Cholinesterase Inhibitors; Donepezil; Ethics; Hallucinations; Humans; Indans; Lewy Body Disease; Male; Mental Disorders; Piperidines | 2002 |
[Latest therapies for treating dementia].
Topics: Adult; Aged; Alzheimer Disease; Amitriptyline; Antidepressive Agents, Second-Generation; Antidepressive Agents, Tricyclic; Antipsychotic Agents; Clinical Trials as Topic; Cognition; Cohort Studies; Controlled Clinical Trials as Topic; Dementia, Vascular; Donepezil; Female; Fluoxetine; Galantamine; Haloperidol; Hormone Replacement Therapy; Humans; Hydroxychloroquine; Indans; Middle Aged; Nootropic Agents; Piperidines; Placebos; Practice Guidelines as Topic; Quality of Life; Randomized Controlled Trials as Topic; Selective Serotonin Reuptake Inhibitors; Time Factors; Trazodone | 2002 |
Research and development of donepezil hydrochloride, a new type of acetylcholinesterase inhibitor.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Design; Humans; Indans; Piperidines; Structure-Activity Relationship | 2002 |
Guidelines for managing Alzheimer's disease: Part II. Treatment.
Topics: Advance Directives; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Disease Progression; Donepezil; Humans; Indans; Lorazepam; Patient Education as Topic; Phenylcarbamates; Piperidines; Risperidone; Rivastigmine | 2002 |
Understanding and managing behavioural symptoms in Alzheimer's disease and related dementias: focus on rivastigmine.
Topics: Acetylcholine; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Disease Progression; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome | 2002 |
Clinical use of cholinomimetic agents: a review.
Topics: Administration, Oral; Adult; Aged; Alzheimer Disease; Brain Injuries; Carbamates; Clinical Trials as Topic; Cytidine Diphosphate Choline; Donepezil; Female; Follow-Up Studies; Humans; Indans; Injections, Intravenous; Injury Severity Score; Male; Middle Aged; Parasympathomimetics; Phenylcarbamates; Physostigmine; Piperidines; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2002 |
Donepezil and rivastigmine in the treatment of Alzheimer's disease: a best-evidence synthesis of the published data on their efficacy and cost-effectiveness.
Topics: Aged; Alzheimer Disease; Canada; Carbamates; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Humans; Indans; Middle Aged; Multicenter Studies as Topic; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2002 |
The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia.
Topics: Behavioral Symptoms; Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2002 |
The tolerability and safety of cholinesterase inhibitors in the treatment of dementia.
Topics: Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2002 |
Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors.
Topics: Aging; Alzheimer Disease; Biological Availability; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Half-Life; Humans; Indans; Intestinal Absorption; Liver; Phenylcarbamates; Piperidines; Protein Binding; Rivastigmine; Tacrine; Tissue Distribution | 2002 |
Medical treatment of Alzheimer's disease: past, present, and future.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Forecasting; Galantamine; Humans; Indans; Male; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2002 |
Drugs under investigation for attention-deficit hyperactivity disorder.
Topics: Animals; Antidepressive Agents; Atomoxetine Hydrochloride; Attention Deficit Disorder with Hyperactivity; Benzhydryl Compounds; Central Nervous System Stimulants; Clinical Trials as Topic; Cyclobutanes; Donepezil; Histamine Agonists; Humans; Indans; Modafinil; Nootropic Agents; Piperidines; Propylamines | 2002 |
Peripheral and dual binding site acetylcholinesterase inhibitors: implications in treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Binding Sites; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Molecular Conformation; Molecular Structure; Phenylcarbamates; Piperidines; Rivastigmine; Structure-Activity Relationship; Tacrine | 2001 |
Clinical and cost-effectiveness of donepezil, rivastigmine, and galantamine for Alzheimer's disease. A systematic review.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cost of Illness; Cost-Benefit Analysis; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Quality of Life; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2002 |
Donepezil: tolerability and safety in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials, Phase II as Topic; Clinical Trials, Phase III as Topic; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Randomized Controlled Trials as Topic | 2002 |
Donepezil treatment of vascular dementia.
Topics: Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2002 |
[Anti-dementia drugs for Alzheimer disease in present and future].
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Design; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; tau Proteins | 2002 |
[Mild Cognitive Impairment: potential therapeutics].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dopamine Agonists; Humans; Indans; Neuropsychological Tests; Piperidines; Severity of Illness Index; Vitamin E | 2002 |
Egg white protein-bonded columns and their applications.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Avidin; Chromatography, High Pressure Liquid; Conalbumin; Donepezil; Egg White; Flavoproteins; Indans; Ketoprofen; Piperidines; Stereoisomerism | 2000 |
[Advances in search for acetylcholinesterase inhibitor based on the double active sites hypothesis].
Topics: Alkaloids; Cholinesterase Inhibitors; Donepezil; Indans; Molecular Conformation; Molecular Structure; Piperidines; Sesquiterpenes; Tacrine | 2002 |
A clinical overview of cholinesterase inhibitors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Galantamine; Humans; Indans; Neuropsychological Tests; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2002 |
Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder.
Topics: Acetates; Amines; Anticonvulsants; Antimanic Agents; Antipsychotic Agents; Benzodiazepines; Bipolar Disorder; Calcium Channel Blockers; Carbamazepine; Clozapine; Cyclohexanecarboxylic Acids; Dibenzothiazepines; Donepezil; Fatty Acids, Omega-3; Fructose; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Lamotrigine; Lithium Carbonate; Olanzapine; Piperazines; Piperidines; Pirenzepine; Quetiapine Fumarate; Risperidone; Thiazoles; Topiramate; Treatment Outcome; Triazines; Valproic Acid | 2003 |
Donepezil for dementia due to Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2003 |
Current treatments for Alzheimer's disease: cholinesterase inhibitors.
Topics: Alzheimer Disease; Behavioral Symptoms; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Multicenter Studies as Topic; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2003 |
Dementia.
Topics: Alzheimer Disease; Anticonvulsants; Antipsychotic Agents; Carbamates; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phosphatidylcholines; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine; Vitamin E | 2003 |
Update on Alzheimer drugs (donepezil).
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2003 |
[Diffuse Lewy body disease].
Topics: Cholinesterase Inhibitors; Donepezil; History, 20th Century; Humans; Indans; Lewy Body Disease; Piperidines; Practice Guidelines as Topic | 2003 |
[Current therapy of patients with dementia].
Topics: Activities of Daily Living; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Controlled Clinical Trials as Topic; Dementia; Dementia, Vascular; Donepezil; Dopamine Agents; Female; Galantamine; Ginkgo biloba; Humans; Indans; Male; Memantine; Meta-Analysis as Topic; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Placebos; Plant Preparations; Prospective Studies; Rivastigmine; Tacrine; Time Factors | 2003 |
[Subcortical vascular encephalopathy].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amantadine; Brain; Carbamates; Clinical Trials as Topic; Dementia, Vascular; Diagnosis, Differential; Donepezil; Dopamine Agents; Gait; Humans; Indans; Magnetic Resonance Imaging; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Pilot Projects; Piperidines; Placebos; Prognosis; Risk Factors; Rivastigmine; Time Factors; Tomography, X-Ray Computed; Walking | 2003 |
[Amnestic syndrome].
Topics: Amnesia; Cholinesterase Inhibitors; Diagnostic and Statistical Manual of Mental Disorders; Donepezil; Humans; Indans; Piperidines; Syndrome; Thiamine | 2003 |
[Dementia with Lewy bodies].
Topics: Aged; Antipsychotic Agents; Brain; Cholinesterase Inhibitors; Diagnostic Imaging; Donepezil; Dopamine Agonists; Humans; Indans; Lewy Body Disease; Male; Piperidines | 2003 |
[Spinocerebellar degeneration].
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Donepezil; Female; Humans; Indans; Male; Mental Disorders; Piperidines; Spinocerebellar Degenerations; Thyrotropin-Releasing Hormone; Trinucleotide Repeat Expansion | 2003 |
[Mechanisms of action of Alzheimer medications].
Topics: Alzheimer Disease; Animals; Carbamates; Cholinesterase Inhibitors; Cognition; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Rivastigmine | 2003 |
Donepezil: in vascular dementia.
Topics: Administration, Oral; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Indans; Piperidines; Psychiatric Status Rating Scales | 2003 |
Donepezil: a clinical review of current and emerging indications.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Piperidines; Psychiatric Status Rating Scales; Receptors, Cholinergic; Schizophrenia | 2004 |
Strategies for continued successful treatment of Alzheimer's disease: switching cholinesterase inhibitors.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Rivastigmine; Treatment Failure; Treatment Outcome | 2003 |
Acetylcholinesterase inhibition in Alzheimer's Disease.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2004 |
Donepezil for vascular cognitive impairment.
Topics: Activities of Daily Living; Cognition Disorders; Dementia, Vascular; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2004 |
[Treatment of vascular dementia].
Topics: Activities of Daily Living; Anticoagulants; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Humans; Indans; Patient Care Team; Piperidines; Quality of Life; Secondary Prevention; Selective Serotonin Reuptake Inhibitors; Warfarin | 2004 |
[Drugs for the treatment of Alzheimer's disease].
Topics: Acetylcholine; Alzheimer Disease; Antidepressive Agents; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Haloperidol; Humans; Hydroxyzine; Hypnotics and Sedatives; Indans; Injections, Intramuscular; Physostigmine; Piperidines; Selective Serotonin Reuptake Inhibitors; Tacrine | 2004 |
[Prognosis in Alzheimer's disease].
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Humans; Indans; Mental Processes; Piperidines; Prognosis; Risk; Selegiline; Survival Rate; Time Factors; Vitamin E | 2004 |
[Limbic neurofibrillary tangle dementia].
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Diagnosis, Differential; Donepezil; Female; Humans; Indans; Limbic System; Male; Neurofibrillary Tangles; Piperidines | 2004 |
[Vitamin B1].
Topics: Biomarkers; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Magnetic Resonance Imaging; Piperidines; Thiamine; Thiamine Deficiency; Wernicke Encephalopathy | 2004 |
[Differential diagnosis of and therapy for senile dementia].
Topics: Aged; Alzheimer Disease; Cerebral Cortex; Cholinesterase Inhibitors; Diagnosis, Differential; Diagnostic and Statistical Manual of Mental Disorders; Diet Therapy; Donepezil; Exercise Therapy; Hippocampus; Humans; Indans; Memory; Piperidines; Platelet Aggregation Inhibitors; Psychotherapy; Reference Standards | 2004 |
Cholinesterase inhibitors used in the treatment of Alzheimer's disease: the relationship between pharmacological effects and clinical efficacy.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Animals; Behavioral Symptoms; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Tolerance; Galantamine; Humans; Indans; Piperidines; Rats; Receptors, Nicotinic | 2004 |
[Drug therapy for aged patients with Alzheimer disease].
Topics: Aged; Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Cholinesterase Inhibitors; Donepezil; Drug Design; Endopeptidases; Enzyme Inhibitors; Galantamine; Humans; Indans; Piperidines; Severity of Illness Index | 2004 |
[Memantine (Ebixa), glutaminergic modulator].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Glutamine; Humans; Indans; Memantine; Piperidines | 2004 |
Review of donepezil, rivastigmine, galantamine and memantine for the treatment of dementia in Alzheimer's disease in adults with Down syndrome: implications for the intellectual disability population.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Down Syndrome; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2004 |
NMDA receptor antagonists. A new therapeutic approach for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Excitatory Amino Acid Antagonists; Glutamic Acid; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2004 |
Evidence-based pharmacotherapy of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinergic Agents; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Evidence-Based Medicine; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Research Design; Rivastigmine | 2004 |
Ginkgo biloba compared with cholinesterase inhibitors in the treatment of dementia: a review based on meta-analyses by the cochrane collaboration.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Multicenter Studies as Topic; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Plant Extracts; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2004 |
Donepezil for the symptomatic treatment of patients with mild to moderate Alzheimer's disease: a meta-analysis of individual patient data from randomised controlled trials.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Piperidines; Randomized Controlled Trials as Topic | 2004 |
[Pre-clinical evaluation of effects of acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: PET study in conscious monkeys].
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Frontal Lobe; Haplorhini; Humans; Indans; Memory; Microdialysis; Piperidines; Positron-Emission Tomography | 2004 |
[Scope and limitations of acetylcholinesterase inhibitors].
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Design; Humans; Indans; Neuroprotective Agents; Neurotransmitter Agents; Piperidines | 2004 |
The benefits and risks associated with cholinesterase inhibitor therapy in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Basal Ganglia Diseases; Bradycardia; Central Nervous System Diseases; Cholinesterase Inhibitors; Clinical Trials as Topic; Comorbidity; Donepezil; Double-Blind Method; Drug Evaluation; Drug Interactions; Female; Galantamine; Gastrointestinal Diseases; Humans; Indans; Institutionalization; Longitudinal Studies; Male; Memantine; Meta-Analysis as Topic; Mice; Middle Aged; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Single-Blind Method; Sleep Wake Disorders; Treatment Outcome | 2004 |
[Doubtful evidence for the use of the cholinesterase inhibitor donepezil in patients with dementia--a systematic review].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Research Design | 2004 |
Mild cognitive impairment: a treatment at last?
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Humans; Indans; Piperidines | 2004 |
The safety and tolerability of donepezil in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Cardiovascular Diseases; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Humans; Indans; Piperidines; Sleep Wake Disorders; Weight Loss | 2004 |
Mechanisms of action of cognitive enhancers on neuroreceptors.
Topics: Alzheimer Disease; Animals; Donepezil; Galantamine; Humans; Indans; Nicotinic Agonists; Nootropic Agents; Piperidines; Pyrrolidinones; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic | 2004 |
Treatment of vascular dementia--evidence from clinical trials with cholinesterase inhibitors.
Topics: Aged; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Parasympathetic Nervous System; Phenylcarbamates; Piperidines; Rivastigmine | 2004 |
Donepezil in the treatment of vascular dementia.
Topics: Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Neuropsychological Tests; Piperidines; Randomized Controlled Trials as Topic | 2004 |
Representation of patients with dementia in clinical trials of donepezil.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Dementia; Donepezil; Female; Humans; Indans; Male; Middle Aged; Ontario; Patient Dropouts; Patient Selection; Piperidines; Practice Patterns, Physicians'; Randomized Controlled Trials as Topic | 2004 |
The acetylcholinesterase inhibitors for treatment of cognitive and behavioral symptoms in dementia with Lewy bodies.
Topics: Aged; Basal Ganglia Diseases; Behavior; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Cognition Disorders; Donepezil; Humans; Indans; Lewy Body Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Tacrine | 2004 |
Dementia: finding the signals in the noise.
Topics: Alzheimer Disease; Dementia; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Magnetic Resonance Imaging; Mental Status Schedule; Nootropic Agents; Piperidines; Positron-Emission Tomography; Randomized Controlled Trials as Topic; Risk Factors; Sensitivity and Specificity | 2005 |
Dementia.
Topics: Alzheimer Disease; Antipsychotic Agents; Benzodiazepines; Cognition; Dementia; Donepezil; Galantamine; Ginkgo biloba; Haloperidol; Humans; Indans; Memantine; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Risperidone; Rivastigmine; Selegiline; Tacrine; Vitamin E | 2004 |
A comparison of donepezil and galantamine in the treatment of cognitive symptoms of Alzheimer's disease: a meta-analysis.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Male; Nootropic Agents; Piperidines; Treatment Outcome | 2005 |
Cognitive, global, and functional benefits of donepezil in Alzheimer's disease and vascular dementia: results from large-scale clinical trials.
Topics: Aged; Alzheimer Disease; Cognition; Dementia, Vascular; Donepezil; Female; Humans; Indans; Male; Multicenter Studies as Topic; Neuropsychological Tests; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2005 |
Donepezil (Aricept) for treatment of Alzheimer's disease and other dementing conditions.
Topics: Alzheimer Disease; Anorexia; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Dementia; Diarrhea; Donepezil; Drug Interactions; Humans; Indans; Nausea; Piperidines; Treatment Outcome; Vomiting | 2004 |
Cholinesterase inhibitors in the treatment of dementia.
Topics: Acetylcholine; Acetylcholinesterase; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cost of Illness; Dementia; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Severity of Illness Index | 2005 |
Dementia.
Topics: Alzheimer Disease; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Tacrine | 2004 |
Cognitive performance in patients with Alzheimer's disease receiving cholinesterase inhibitors for up to 5 years.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Galantamine; Humans; Indans; Long-Term Care; Phenylcarbamates; Piperidines; Rivastigmine | 2005 |
[Community strategies for rehabilitation in senile dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Community Mental Health Services; Diagnosis, Differential; Donepezil; Family; Female; Humans; Indans; Lewy Body Disease; Male; Memory; Piperidines; Social Support; Tomography, Emission-Computed, Single-Photon | 2005 |
Refining treatment guidelines in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antiparkinson Agents; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Female; Humans; Indans; Male; Memantine; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2005 |
Pharmacologic treatment options in Alzheimer's disease: optimizing disease management.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Disease Management; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Glutamic Acid; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Tacrine; Treatment Outcome | 2005 |
Cholinesterase inhibitors for patients with Alzheimer's disease: systematic review of randomised clinical trials.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2005 |
Cholinergic treatment: what are the early neuropathological targets?
Topics: Aged; Alzheimer Disease; Brain; Cholinergic Agents; Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Hypoxia, Brain; Indans; Nervous System; Piperidines | 2005 |
Alzheimer's disease: the benefits of early treatment.
Topics: Aged; Alzheimer Disease; Cerebral Infarction; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2005 |
Dementia with cerebrovascular disease: the benefits of early treatment.
Topics: Cerebrovascular Disorders; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Diagnosis, Differential; Disease Progression; Donepezil; Humans; Indans; Nootropic Agents; Parasympathetic Nervous System; Piperidines | 2005 |
Drug therapy of dementia in elderly patients. A review.
Topics: Aged; Alzheimer Disease; Dementia; Donepezil; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2005 |
Clinical trials in mild cognitive impairment: lessons for the future.
Topics: Aged; Alzheimer Disease; Anti-Inflammatory Agents; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Lactones; Neuropsychological Tests; Phenylcarbamates; Piperidines; Rivastigmine; Severity of Illness Index; Sulfones; Vitamin E | 2006 |
A systematic review of the clinical effectiveness of donepezil, rivastigmine and galantamine on cognition, quality of life and adverse events in Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Quality of Life; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2006 |
Circadian cholinergic rhythms: implications for cholinesterase inhibitor therapy.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Circadian Rhythm; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Sleep; Sleep, REM | 2006 |
[Cognitive dysfunction and dementia associated with elderly diabetes].
Topics: Aged; Antihypertensive Agents; Brain; Cognition Disorders; Dementia; Diabetes Mellitus, Type 2; Donepezil; Glucose; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperglycemia; Hyperlipidemias; Hypertension; Indans; Piperidines; Risk; Risk Factors | 2006 |
The clinical and cost-effectiveness of donepezil, rivastigmine, galantamine and memantine for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cost-Benefit Analysis; Donepezil; Dopamine Agents; Evidence-Based Medicine; Female; Galantamine; Humans; Indans; Male; Memantine; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome; United Kingdom | 2006 |
Donepezil for dementia due to Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2006 |
Cholinesterase inhibitors for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2006 |
Dementia.
Topics: Alzheimer Disease; Benzodiazepines; Dementia; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Nootropic Agents; Olanzapine; Phenylcarbamates; Physostigmine; Phytotherapy; Piperidines; Rivastigmine; Selegiline; Tacrine | 2005 |
Advances in alternative pharmacotherapy of ADHD.
Topics: Adrenergic alpha-Agonists; Antidepressive Agents, Tricyclic; Attention Deficit Disorder with Hyperactivity; Bupropion; Clonidine; Donepezil; Humans; Indans; Piperidines; Treatment Outcome | 2005 |
Navigating patients and caregivers through the course of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Mass Screening; Memantine; Middle Aged; Neurologic Examination; Neuropsychological Tests; Patient Care Management; Physical Examination; Piperidines; Practice Guidelines as Topic; Prevalence; Randomized Controlled Trials as Topic; Severity of Illness Index; Stress, Psychological; Treatment Outcome | 2006 |
Clinical inquiries. Does treatment with donepezil improve memory for patients with mild cognitive impairment?
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Humans; Indans; Memory; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2006 |
[Cognitive impairment].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Therapy, Combination; Estrogen Replacement Therapy; Estrogens; Female; Humans; Indans; Male; Medroxyprogesterone; Menopause; Mental Status Schedule; Piperidines; Prognosis; Risk Factors; Sex Factors | 2006 |
Current and emerging pharmacological treatment options for dementia.
Topics: Acetylcholine; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Neurodegenerative Diseases; Neuroprotective Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2006 |
Rationale for combination therapy with galantamine and memantine in Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Severity of Illness Index | 2006 |
Donepezil for mild cognitive impairment.
Topics: Donepezil; Humans; Indans; Memory Disorders; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2006 |
Donepezil: a review.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2005 |
Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Male; Molecular Biology; Phenylcarbamates; Piperidines; Plaque, Amyloid; Positron-Emission Tomography; Randomized Controlled Trials as Topic; Rivastigmine; tau Proteins | 2006 |
[Mechanisms of neuroprotective effects of therapeutic acetylcholinesterase inhibitors used in treatment of Alzheimer's disease].
Topics: Alzheimer Disease; Animals; Cell Death; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Humans; Indans; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine | 2006 |
[Drug treatment for geriatric urinary disorders; current concept].
Topics: Aged; Aged, 80 and over; Amantadine; Cerebral Infarction; Cholinergic Antagonists; Cognition Disorders; Deamino Arginine Vasopressin; Diagnosis, Differential; Donepezil; Humans; Indans; Levodopa; Piperidines; Quality of Life; Serotonin Agents; Urination Disorders | 2006 |
[Pharmacotherapy for Alzheimer's disease].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2006 |
Pharmacotherapy of aphasia: myth or reality?
Topics: Amphetamine; Aphasia; Bromocriptine; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dopamine Agents; Fluoxetine; GABA Agonists; Humans; Indans; Neuroprotective Agents; Paroxetine; Physostigmine; Piperidines; Piracetam; Pyridines; Selective Serotonin Reuptake Inhibitors; Serotonin; Stroke; Zolpidem | 2007 |
[Medical treatment of Alzheimer's disease].
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Dementia, Vascular; Disease Progression; Donepezil; Evidence-Based Medicine; Galantamine; Humans; Indans; Lewy Body Disease; Memantine; Nootropic Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2006 |
Use of antidementia agents in vascular dementia: beyond Alzheimer disease.
Topics: Cholinesterase Inhibitors; Dementia, Vascular; Diagnosis, Differential; Donepezil; Dopamine Agents; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Stroke | 2006 |
Cognitive dysfunctions in schizophrenia: potential benefits of cholinesterase inhibitor adjunctive therapy.
Topics: Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Schizophrenic Psychology; Treatment Outcome | 2006 |
Relevance of donepezil in enhancing learning and memory in special populations: a review of the literature.
Topics: Alzheimer Disease; Animals; Attention; Attention Deficit Disorder with Hyperactivity; Autistic Disorder; Brain Injuries; Donepezil; Down Syndrome; Humans; Indans; Learning Disabilities; Memory Disorders; Mental Recall; Nootropic Agents; Piperidines; Schizophrenia; Treatment Outcome | 2007 |
Treatment strategies for the behavioral symptoms of Alzheimer's disease: focus on early pharmacologic intervention.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Memantine; Mental Disorders; Piperidines; Time Factors | 2007 |
The application of evidence-based principles of care in older persons (issue 5): Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Geriatric Assessment; Humans; Indans; Mental Disorders; Nootropic Agents; Phenylcarbamates; Piperidines; Positron-Emission Tomography; Rivastigmine; Tacrine | 2007 |
Early identification of cognitive deficits: preclinical Alzheimer's disease and mild cognitive impairment.
Topics: Adult; Alzheimer Disease; Cognition Disorders; Disease Progression; Donepezil; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Piperidines; Predictive Value of Tests; Randomized Controlled Trials as Topic; Risk Assessment; Time Factors; Vitamin E | 2007 |
[Delirium].
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Confusion; Delirium; Diagnosis, Differential; Donepezil; Humans; Indans; Patient Care Team; Piperidines; Risk Factors | 2007 |
Interventions for preventing delirium in hospitalised patients.
Topics: Anesthesia, Epidural; Anesthetics, Inhalation; Cytidine Diphosphate Choline; Delirium; Donepezil; Halothane; Hospitalization; Humans; Indans; Nootropic Agents; Piperidines | 2007 |
Potential ethnic modifiers in the assessment and treatment of Alzheimer's disease: challenges for the future.
Topics: Aged; Alzheimer Disease; Cross-Cultural Comparison; Donepezil; Ethnicity; Galantamine; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Thiazoles; White People | 2007 |
Donepezil: an update.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Nootropic Agents; Parkinson Disease; Piperidines | 2007 |
[Cholinesterase inhibitors and Alzheimer's disease: meta-analysis of the verification of effectiveness, origin and bias of results in published studies].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Publication Bias; Randomized Controlled Trials as Topic; Rivastigmine; Severity of Illness Index; Treatment Outcome | 2007 |
[Management of Alzheimer disease].
Topics: Aged; Alzheimer Disease; Animals; Antipsychotic Agents; Caregivers; Case Management; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dopamine Agents; Excitatory Amino Acid Antagonists; Follow-Up Studies; Forecasting; Health Education; Humans; Indans; Memantine; Mental Disorders; Meta-Analysis as Topic; Nootropic Agents; Occupational Therapy; Piperidines; Practice Guidelines as Topic; Psychotropic Drugs; Randomized Controlled Trials as Topic; Time Factors | 2007 |
Efficacy and adverse effects of cholinesterase inhibitors and memantine in vascular dementia: a meta-analysis of randomised controlled trials.
Topics: Cholinesterase Inhibitors; Databases, Bibliographic; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Evaluation; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Odds Ratio; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Time Factors; Treatment Outcome | 2007 |
Mild cognitive impairment and dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Dementia; Donepezil; Humans; Indans; Models, Psychological; Neuropsychological Tests; Piperidines; Syndrome; Terminology as Topic; Treatment Outcome | 2006 |
[Acetylcholinesterase inhibitors for dementia--an update].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Time Factors | 2007 |
Modelling disease progression in Alzheimer's disease: a review of modelling methods used for cost-effectiveness analysis.
Topics: Alzheimer Disease; Cost-Benefit Analysis; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Models, Economic; Phenylcarbamates; Piperidines; Rivastigmine | 2007 |
Donepezil for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2007 |
[Are anti-dementia drugs worthwhile?].
Topics: Activities of Daily Living; Alzheimer Disease; Antiparkinson Agents; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Dopamine Agents; Drug Therapy, Combination; Economics, Medical; Excitatory Amino Acid Antagonists; Galantamine; Germany; Health Policy; Humans; Indans; Memantine; Meta-Analysis as Topic; Neuroprotective Agents; Nootropic Agents; Parasympathomimetics; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Time Factors | 2007 |
[Therapy of cognitive deficits in schizophrenia with acetylcholinesterase inhibitors. A systematic overview].
Topics: Antipsychotic Agents; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Physostigmine; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2008 |
Recent developments in cholinesterases inhibitors for Alzheimer's disease treatment.
Topics: Alkaloids; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Indole Alkaloids; Isoquinolines; Phenylcarbamates; Physostigmine; Piperidines; Propidium; Rivastigmine; Steroids; Tacrine | 2007 |
[Alpha2-adrenergic receptors in the dorsal horn of the spinal cord--their function and the descending inhibitory systems].
Topics: Acetylcholine; Adrenergic alpha-2 Receptor Agonists; Amines; Analgesics; Animals; Brain-Derived Neurotrophic Factor; Chronic Disease; Clonidine; Cyclohexanecarboxylic Acids; Donepezil; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Neuralgia; Norepinephrine; Piperidines; Posterior Horn Cells; Receptors, Adrenergic, alpha-2; Receptors, Muscarinic | 2007 |
Practical clinical use of therapeutic agents for Alzheimer's disease.
Topics: Alzheimer Disease; Antipsychotic Agents; Behavioral Symptoms; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2007 |
[Neuronal migration in the adult brain].
Topics: Adult; Alzheimer Disease; Animals; Brain; Cell Differentiation; Cell Movement; Cell Survival; Cerebrospinal Fluid; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Ependyma; Humans; Indans; Mice; Neurons; Olfactory Bulb; Piperidines; Regenerative Medicine; Stimulation, Chemical | 2007 |
Diagnosis and management of vascular cognitive impairment.
Topics: Central Nervous System Agents; Clinical Trials as Topic; Cognition Disorders; Dementia, Vascular; Donepezil; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Risk Factors; Rivastigmine | 2007 |
Cholinesterase inhibitors for delirium.
Topics: Cholinesterase Inhibitors; Delirium; Donepezil; Humans; Indans; Piperidines | 2008 |
[Cholinesterase inhibitors in the treatment of dementia--are they useful in clinical practice?].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Dementia, Vascular; Donepezil; Evidence-Based Medicine; Galantamine; Humans; Indans; Lewy Body Disease; Phenylcarbamates; Piperidines; Rivastigmine; Time Factors; Treatment Outcome | 2008 |
Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine | 2008 |
Pharmacologic management of Alzheimer disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Memantine; N-Methylaspartate; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2008 |
The mechanisms of neurodegenerative processes and current pharmacotherapy of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Nerve Degeneration; Piperidines | 2008 |
Clinical inquiries. What could be behind your elderly patient's subjective memory complaints?
Topics: Aged; Cognition; Depression; Donepezil; Geriatric Assessment; Ginkgo biloba; Humans; Indans; Memory Disorders; Nootropic Agents; Phytotherapy; Piperidines; Polypharmacy; Thinking | 2008 |
[Novel therapeutic strategy for neurogenesis in the neurodegenerative disorders].
Topics: Animals; Cognition; Donepezil; Drug Design; Extracellular Signal-Regulated MAP Kinases; Hippocampus; Humans; Indans; Lithium Carbonate; Nerve Regeneration; Neurodegenerative Diseases; Piperidines; Stimulation, Chemical; Valproic Acid; Vanadium Compounds | 2008 |
[Treatment of Alzheimer's disease: status quo and future considerations].
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Behavioral Symptoms; Choline; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Design; Galantamine; Glutamic Acid; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Risk Factors; Rivastigmine | 2008 |
[Neuronal migration in the adult brain].
Topics: Adult Stem Cells; Alzheimer Disease; Animals; Cell Differentiation; Cell Division; Cell Movement; Cell Survival; Cerebral Ventricles; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Mice; Nerve Regeneration; Neurons; Olfactory Bulb; Piperidines | 2008 |
Diagnosis and treatment of dementia with Lewy bodies.
Topics: Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Nootropic Agents; Phenylcarbamates; Piperidines; Prognosis; Rivastigmine; Tacrine | 2008 |
Disease-modifying approaches to Alzheimer's disease: challenges and opportunities-Lessons from donepezil therapy.
Topics: Alzheimer Disease; Biomarkers; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Piperidines; Research Design | 2008 |
Results, rhetoric, and randomized trials: the case of donepezil.
Topics: Advertising; Aged; Alzheimer Disease; Conflict of Interest; Donepezil; Drug Industry; Drug Utilization; Evidence-Based Medicine; Humans; Indans; Manuscripts, Medical as Topic; Marketing; Nootropic Agents; Piperidines; Psycholinguistics; Randomized Controlled Trials as Topic | 2008 |
Efficacy and safety of donepezil, galantamine, and rivastigmine for the treatment of Alzheimer's disease: a systematic review and meta-analysis.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2008 |
Normal pressure hydrocephalus presenting as Othello syndrome: case presentation and review of the literature.
Topics: Aged; Antipsychotic Agents; Cerebral Ventricles; Cholinesterase Inhibitors; Cognition Disorders; Corpus Callosum; Delusions; Diagnosis, Differential; Donepezil; Female; Humans; Hydrocephalus, Normal Pressure; Indans; Magnetic Resonance Imaging; Memantine; Piperidines; Severity of Illness Index; Sexual Behavior; Spouses; Ventriculoperitoneal Shunt | 2008 |
Donepezil: potential neuroprotective and disease-modifying effects.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Neuroprotective Agents; Piperidines | 2008 |
Pharmacological treatment in moderate-to-severe Alzheimer's disease.
Topics: Alzheimer Disease; Donepezil; Double-Blind Method; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rivastigmine; Selegiline; Severity of Illness Index; Vitamin E | 2008 |
Reports in pharmacological treatments in geriatric psychiatry: is there anything new or just adding to old evidence?
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Therapy; Evidence-Based Medicine; Geriatric Psychiatry; Humans; Indans; Lewy Body Disease; Parkinson Disease; Piperidines | 2008 |
[Clinical and pathological findings in dementia with Lewy bodies].
Topics: Aged; Atrophy; Brain; Cholinesterase Inhibitors; Diagnosis, Differential; Diagnostic Imaging; Donepezil; Female; Humans; Indans; Lewy Body Disease; Piperidines; Reference Standards | 2008 |
[Diagnosis of and therapy for Alzheimer-type dementia].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antipsychotic Agents; Brain; Cholinesterase Inhibitors; Diagnostic and Statistical Manual of Mental Disorders; Dibenzothiazepines; Donepezil; Humans; Indans; Neurofibrils; Piperidines; Plaque, Amyloid; Quetiapine Fumarate; Reference Standards; Selective Serotonin Reuptake Inhibitors; tau Proteins | 2008 |
Integrating symptomatic- and disease-modifying treatments.
Topics: Aged; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neuropsychological Tests; Piperidines; Positron-Emission Tomography | 2008 |
[Relation between Pisa syndrome and choline esterase inhibitors in a cohort of Alzheimer's disease patients].
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Dystonia; Galantamine; Humans; Indans; Male; Piperidines; Syndrome | 2009 |
Pharmacotherapy in restorative neurology.
Topics: Brain Injuries; Donepezil; Dopamine Uptake Inhibitors; Humans; Indans; Methylphenidate; Movement; Nootropic Agents; Piperidines; Recovery of Function; Stroke | 2008 |
Three-year follow-up of a patient with early-onset Alzheimer's disease with presenilin-2 N141I mutation - case report and review of the literature.
Topics: Age of Onset; Alzheimer Disease; Cholinesterase Inhibitors; Codon; Donepezil; Electrophysiology; Excitatory Amino Acid Antagonists; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Indans; Male; Memantine; Middle Aged; Mutation, Missense; Neuropsychological Tests; Pedigree; Piperidines; Presenilin-2; Radiography; Radionuclide Imaging; Radiopharmaceuticals; tau Proteins; Time Factors; Treatment Outcome | 2008 |
Donepezil for dementia in people with Down syndrome.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Down Syndrome; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 2009 |
[Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse].
Topics: Acetylcholine; Amyloid; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Immunosuppressive Agents; Indans; Inflammation; Mice; Mice, Transgenic; Microglia; Mutation; Neurodegenerative Diseases; Piperidines; Synapses; Tacrolimus; tau Proteins | 2008 |
Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation.
Topics: Acetylcholinesterase; Animals; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Glutamates; Indans; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, Nicotinic; Tacrine; Up-Regulation | 2009 |
Pain and palliative care pharmacotherapy literature summaries and analyses.
Topics: Alzheimer Disease; Amphetamines; Anesthetics, Local; Anticoagulants; Antidepressive Agents; Depression; Donepezil; Drug Therapy; Drug-Related Side Effects and Adverse Reactions; Humans; Indans; Lidocaine; Nootropic Agents; Pain; Palliative Care; Phlebotomy; Piperidines; Prescription Drugs; Psychomotor Agitation; Randomized Controlled Trials as Topic; Sertraline; Stevens-Johnson Syndrome; Thromboembolism | 2009 |
Discontinuing Alzheimer's disease drug therapy: why, when, and how.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Approval; Drug Monitoring; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Nursing Homes; Patient Selection; Phenylcarbamates; Piperidines; Prevalence; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Severity of Illness Index; Treatment Failure; United States; Withholding Treatment | 2008 |
Donepezil (aricept) as a treatment for anorexia nervosa: a very feasible therapeutic possibility.
Topics: Animals; Anorexia Nervosa; Donepezil; Humans; Indans; Piperidines; Treatment Outcome | 2009 |
Donepezil in the treatment of patients with Alzheimer's disease.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2009 |
Treatment of Alzheimer's disease in the long-term-care setting.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Galantamine; Humans; Indans; Long-Term Care; Memantine; Phenylcarbamates; Piperidines; Rivastigmine | 2009 |
Are cholinesterase inhibitors effective in the management of the behavioral and psychological symptoms of dementia in Alzheimer's disease? A systematic review of randomized, placebo-controlled trials of donepezil, rivastigmine and galantamine.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Galantamine; Humans; Indans; Mental Disorders; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2009 |
Cholinergic deficiency involved in vascular dementia: possible mechanism and strategy of treatment.
Topics: Acetylcholine; Alkaloids; Animals; Anti-Inflammatory Agents; Cholinergic Agents; Cholinesterase Inhibitors; Dementia, Vascular; Disease Models, Animal; Donepezil; Galantamine; Humans; Indans; Inflammation; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, Cholinergic; Rivastigmine; Sesquiterpenes; Signal Transduction | 2009 |
[Final IQWiG to Ginkgo biloba].
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Clinical Trials as Topic; Cognition; Donepezil; Ginkgo biloba; Humans; Indans; Mental Processes; Nootropic Agents; Piperidines; Plant Extracts; Quality of Life | 2009 |
Donepezil treatment in severe Alzheimer's disease: a pooled analysis of three clinical trials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Middle Aged; Multicenter Studies as Topic; Nootropic Agents; Piperidines; Placebos; Randomized Controlled Trials as Topic; Severity of Illness Index; Treatment Outcome | 2009 |
Safety and tolerability of donepezil, rivastigmine and galantamine for patients with Alzheimer's disease: systematic review of the 'real-world' evidence.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2009 |
Switching from oral cholinesterase inhibitors to the rivastigmine transdermal patch.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Databases, Factual; Donepezil; Female; Humans; Indans; Male; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Retrospective Studies; Rivastigmine | 2010 |
[Care continuity for patients with Down syndrome during transition from childhood to adulthood].
Topics: Adolescent; Adult; Aged; Alzheimer Disease; Child; Comprehensive Health Care; Continuity of Patient Care; Counseling; Donepezil; Down Syndrome; Female; Humans; Indans; Male; Middle Aged; Piperidines; Psychomotor Disorders; Young Adult | 2010 |
Safety and tolerability of rivastigmine transdermal patch compared with rivastigmine capsules in patients switched from donepezil: data from three clinical trials.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Alzheimer Disease; Blood Pressure; Capsules; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Phenylcarbamates; Piperidines; Pulse; Randomized Controlled Trials as Topic; Respiration; Rivastigmine | 2010 |
Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: a systematic review.
Topics: Cholinesterase Inhibitors; Cognition; Donepezil; Emotions; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Motivation; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Rivastigmine | 2010 |
[Donepezil-induced neuroprotection of acetylcholinergic neurons in olfactory bulbectomized mice].
Topics: Alzheimer Disease; Animals; Choline O-Acetyltransferase; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Hippocampus; Humans; Indans; Mice; Neurogenesis; Neurons; Neuroprotective Agents; Nootropic Agents; Olfactory Bulb; Piperidines; Septal Nuclei | 2010 |
Effects of donepezil on activities of daily living: integrated analysis of patient data from studies in mild, moderate and severe Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Ambulatory Care; Assisted Living Facilities; Disability Evaluation; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Multicenter Studies as Topic; Nootropic Agents; Piperidines; Psychometrics; Randomized Controlled Trials as Topic; Skilled Nursing Facilities | 2010 |
Issues facing home-based medical support services.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Caregivers; Delirium; Dementia; Diagnosis, Differential; Donepezil; Home Care Services; House Calls; Humans; Indans; Lewy Body Disease; Male; Nootropic Agents; Piperidines; Psychomotor Agitation; Tokyo | 2010 |
Acetylcholinesterase Inhibitors (AChEI's) for the treatment of visual hallucinations in schizophrenia: a review of the literature.
Topics: Cholinesterase Inhibitors; Donepezil; Galantamine; Hallucinations; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2010 |
Modern care for patients with Alzheimer disease: rationale for early intervention.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cognition; Donepezil; Excitatory Amino Acid Antagonists; Humans; Immunosuppressive Agents; Indans; Memantine; Neuroprotective Agents; Phenylcarbamates; Piperidines; Psychological Tests; Rivastigmine; Severity of Illness Index; Tacrolimus | 2010 |
Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions.
Topics: Aged; Brain; Cholinesterase Inhibitors; Cross-Sectional Studies; Dementia; Diagnosis, Differential; Diagnostic Imaging; Donepezil; Early Diagnosis; Humans; Indans; Lewy Body Disease; Mental Disorders; Neuropsychological Tests; Parkinson Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2010 |
Switching cholinesterase inhibitors in older adults with dementia.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Rivastigmine; Treatment Outcome | 2011 |
Predicting cognitive decline in Alzheimer's disease: an integrated analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Female; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Piperidines; Predictive Value of Tests; Prognosis; Randomized Controlled Trials as Topic; Risk Factors | 2010 |
Progressive cholinergic decline in Alzheimer's Disease: consideration for treatment with donepezil 23 mg in patients with moderate to severe symptomatology.
Topics: Acetylcholine; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Clinical Trials as Topic; Delayed-Action Preparations; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Nerve Degeneration; Piperidines; Severity of Illness Index | 2011 |
Managing cognitive dysfunction through the continuum of Alzheimer's disease: role of pharmacotherapy.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Continuity of Patient Care; Donepezil; Humans; Indans; Memantine; Piperidines; Randomized Controlled Trials as Topic | 2011 |
[Daily functioning in dementia: pharmacological and non-pharmacological interventions demonstrate small effects on heterogeneous scales].
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Angiotensin-Converting Enzyme Inhibitors; Caregivers; Donepezil; Galantamine; Geriatric Assessment; Ginkgo biloba; Humans; Indans; Institutionalization; Memantine; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Plant Extracts; Randomized Controlled Trials as Topic; Rivastigmine | 2011 |
[Cholinesterase inhibitors for treating dementia. Review].
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine | 2010 |
Pharmacologists and Alzheimer disease therapy: to boldly go where no scientist has gone before.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Galantamine; Humans; Indans; Memantine; Neurons; Oxidative Stress; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, Serotonin; Rivastigmine | 2011 |
New drugs for Alzheimer's disease in Japan.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Japan; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2011 |
Use of memantine for the treatment of dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Dopamine Agents; Humans; Indans; Memantine; Neurodegenerative Diseases; Piperidines | 2011 |
Pharmacologic treatment for memory disorder in multiple sclerosis.
Topics: Adult; Donepezil; Ginkgo biloba; Humans; Indans; Memantine; Memory Disorders; Middle Aged; Multiple Sclerosis; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2011 |
Fragile X syndrome and targeted treatment trials.
Topics: Animals; Anti-Bacterial Agents; Antioxidants; Baclofen; Brain-Derived Neurotrophic Factor; Central Nervous System Stimulants; Clinical Trials as Topic; Dendritic Spines; Donepezil; Dopamine; Enzyme Inhibitors; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Indans; Lithium Compounds; Melatonin; Mice; Mice, Knockout; Minocycline; Nootropic Agents; Piperidines; Receptor, Metabotropic Glutamate 5; Receptors, GABA; Receptors, Metabotropic Glutamate; Signal Transduction; Vitamin E | 2012 |
Pharmacological treatment of Alzheimer disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Neuropsychological Tests; Piperidines | 2011 |
New pharmacological strategies for treatment of Alzheimer's disease: focus on disease modifying drugs.
Topics: Alzheimer Disease; Clinical Trials as Topic; Donepezil; Drug Discovery; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Phenylcarbamates; Piperidines; Plaque, Amyloid; Rivastigmine; tau Proteins | 2012 |
[Diagnosis and treatment of cognitive deficits caused by radiation in patients with brain tumours].
Topics: Animals; Biomarkers; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Cytokines; Donepezil; Humans; Hyperbaric Oxygenation; Indans; Magnetic Resonance Imaging; Neuropsychological Tests; Oxidative Stress; Piperidines; Radiosurgery; Radiotherapy; Radiotherapy, Conformal | 2011 |
Reviewing the role of donepezil in the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2012 |
Effective pharmacological management of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Time Factors; Treatment Outcome | 2011 |
The costs of Alzheimer's disease and the value of effective therapies.
Topics: Age Factors; Aging; Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Galantamine; Health Care Costs; Health Expenditures; Humans; Indans; Medicare; Medicare Part D; Memantine; Piperidines; Psychometrics; United States | 2011 |
A systematic review of adverse events in the placebo arm of donepezil trials: the role of cognitive impairment.
Topics: Aged; Alzheimer Disease; Cognitive Dysfunction; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Placebos; Randomized Controlled Trials as Topic | 2012 |
Acetylcholinesterase inhibitors for schizophrenia.
Topics: Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Psychotic Disorders; Randomized Controlled Trials as Topic; Rivastigmine; Schizophrenia; Schizophrenic Psychology | 2012 |
Symptomatic and nonamyloid/tau based pharmacologic treatment for Alzheimer disease.
Topics: Alkaloids; Alzheimer Disease; Amino Acids; Animals; Cholinesterase Inhibitors; Dietary Supplements; Disease Progression; Docosahexaenoic Acids; Donepezil; Drug Approval; Galantamine; Ginkgo biloba; Half-Life; History, 20th Century; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Psychotropic Drugs; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Sesquiterpenes; Vitamin B Complex; Vitamin E | 2012 |
Cholinesterase inhibitor adjunctive therapy for cognitive impairment and depressive symptoms in older adults with depression.
Topics: Antidepressive Agents; Cholinesterase Inhibitors; Cognition Disorders; Depression; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine | 2012 |
Cholinesterase inhibitors for dementia with Lewy bodies, Parkinson's disease dementia and cognitive impairment in Parkinson's disease.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Humans; Indans; Lewy Body Disease; Neuroprotective Agents; Parkinson Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2012 |
Economic evaluation of treatment options in patients with Alzheimer's disease: a systematic review of cost-effectiveness analyses.
Topics: Alzheimer Disease; Cost-Benefit Analysis; Donepezil; Dopamine Agents; Drug Costs; Economics, Pharmaceutical; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Piperidines; Quality-Adjusted Life Years | 2012 |
The effectiveness and cost-effectiveness of donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of Technology Appraisal No. 111): a systematic review and economic model.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Dopamine Agents; Female; Galantamine; Humans; Indans; Male; Memantine; Middle Aged; Models, Economic; Phenylcarbamates; Piperidines; Rivastigmine; Technology Assessment, Biomedical | 2012 |
Gingko biloba extract EGb 761®: clinical data in dementia.
Topics: Activities of Daily Living; Cognition; Dementia; Donepezil; Drug Therapy, Combination; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phytotherapy; Piperidines; Plant Extracts; Quality of Life | 2012 |
Hyperbaric oxygen therapy for vascular dementia.
Topics: Cognition; Combined Modality Therapy; Dementia, Vascular; Donepezil; Humans; Hyperbaric Oxygenation; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2012 |
Induction of lucid dreams: a systematic review of evidence.
Topics: Cholinesterase Inhibitors; Donepezil; Dreams; Humans; Indans; Piperidines; Sleep | 2012 |
Cognitive impairment in ICU survivors: assessment and therapy.
Topics: Cholinesterase Inhibitors; Cognition; Cognition Disorders; Cognitive Behavioral Therapy; Critical Illness; Donepezil; Dopamine Uptake Inhibitors; Humans; Indans; Intensive Care Units; Methylphenidate; Piperidines; Psychometrics; Survivors | 2012 |
Effectiveness of antidementia drugs in delaying Alzheimer's disease progression.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Dopamine Agents; Evidence-Based Medicine; Humans; Indans; Memantine; Nootropic Agents; Piperidines; Prevalence; Randomized Controlled Trials as Topic | 2013 |
Benefits of combined cholinesterase inhibitor and memantine treatment in moderate-severe Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Drug Therapy, Combination; Humans; Indans; Memantine; Piperidines; Severity of Illness Index; Treatment Outcome | 2013 |
[The fundaments of neuronal plasticity].
Topics: Animals; Central Nervous System Depressants; Donepezil; Electrical Synapses; Ethanol; Gene Expression; Hippocampus; Humans; Indans; Long-Term Potentiation; Long-Term Synaptic Depression; Models, Neurological; Neurons; Nootropic Agents; Piperidines; Rats; S100 Proteins; Synaptic Transmission | 2012 |
Assessing the prospect of donepezil in improving cognitive impairment in patients with schizophrenia.
Topics: Binding Sites; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2013 |
A 10-year perspective on donepezil.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Drug Design; Half-Life; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Severity of Illness Index | 2013 |
Higher-dose (23 mg/day) donepezil formulation for the treatment of patients with moderate-to-severe Alzheimer's disease.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2012 |
Pharmacodynamic, pharmacokinetic and pharmacogenetic aspects of drugs used in the treatment of Alzheimer's disease.
Topics: Aging; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Pharmacogenetics; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine | 2013 |
A meta-analysis of the efficacy of donepezil, rivastigmine, galantamine, and memantine in relation to severity of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Behavior; Cholinesterase Inhibitors; Cognition; Data Interpretation, Statistical; Disability Evaluation; Disease Progression; Donepezil; Female; Galantamine; Humans; Indans; Male; Memantine; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2013 |
Charles bonnet syndrome: treating nonpsychiatric hallucinations.
Topics: Aged, 80 and over; Cognition; Dementia; Donepezil; Female; Hallucinations; Humans; Indans; Nootropic Agents; Piperidines; Syndrome; Treatment Outcome; Vision Disorders | 2013 |
High-dose donepezil (23 mg/day) for the treatment of moderate and severe Alzheimer's disease: drug profile and clinical guidelines.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Patient Selection; Piperidines; Practice Guidelines as Topic | 2013 |
[Nitrergic cerebrovascular regulation as affected by donepezil].
Topics: Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nitric Oxide; Piperidines; Stimulation, Chemical; Vasodilation | 2013 |
"Shall I compare thee to a dose of donepezil?": cultural arts interventions in dementia care research.
Topics: Art Therapy; Dementia; Donepezil; Humans; Indans; Piperidines | 2014 |
Language impairment in Alzheimer's disease and benefits of acetylcholinesterase inhibitors.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Communication Disorders; Donepezil; Galantamine; Humans; Indans; Outcome Assessment, Health Care; Phenylcarbamates; Piperidines; Rivastigmine | 2013 |
Atypical aging in Down syndrome.
Topics: Adult; Aging; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Dementia; Donepezil; Down Syndrome; Female; Humans; Incidence; Indans; Intellectual Disability; Male; Metabolic Syndrome; Middle Aged; Nootropic Agents; Oxidative Stress; Peptide Fragments; Phenotype; Piperidines; Prevalence; Telomere Shortening; Treatment Outcome; United States | 2013 |
[Cholinesterase inhibitors in the treatment of mixed dementia].
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Piperidines; Treatment Outcome | 2013 |
Efficacy and safety of cognitive enhancers for patients with mild cognitive impairment: a systematic review and meta-analysis.
Topics: Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2013 |
[Donepezil in Alzheimer's disease and vascular dementia].
Topics: Alzheimer Disease; Dementia, Vascular; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Treatment Outcome | 2013 |
Drugs for cognitive loss and dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Rivastigmine | 2013 |
Emerging pharmacotherapy for cancer patients with cognitive dysfunction.
Topics: Antineoplastic Agents; Central Nervous System Stimulants; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Humans; Indans; Memantine; Neoplasms; Piperidines | 2013 |
Donepezil: an important prototype to the design of new drug candidates for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines | 2014 |
Efficacy of memantine, donepezil, or their association in moderate-severe Alzheimer's disease: a review of clinical trials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Memantine; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2013 |
[Development of therapies for Alzheimer's disease based on cholinergic hypothesis-status quo and future directions].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinergic Neurons; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Galantamine; Humans; Indans; Molecular Targeted Therapy; Neuroprostanes; Phenylcarbamates; Piperidines; Rivastigmine | 2013 |
Pharmacological treatment for memory disorder in multiple sclerosis.
Topics: Adult; Donepezil; Ginkgo biloba; Humans; Indans; Memantine; Memory Disorders; Middle Aged; Multiple Sclerosis; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2013 |
Review of the validated HPLC and LC-MS/MS methods for determination of drugs used in clinical practice for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tandem Mass Spectrometry | 2014 |
Efficacy and safety of donepezil, galantamine, rivastigmine, and memantine for the treatment of Alzheimer's disease: a systematic review and meta-analysis.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2014 |
The effect of funding sources on donepezil randomised controlled trial outcome: a meta-analysis.
Topics: Alzheimer Disease; Cognition; Donepezil; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Research Support as Topic; Treatment Outcome | 2014 |
Pharmacokinetic and pharmacodynamic evaluation of donepezil for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Biological Availability; Cholinesterase Inhibitors; Donepezil; Half-Life; Humans; Indans; Piperidines; Severity of Illness Index; Time Factors; Treatment Outcome | 2014 |
Donepezil-induced cervical dystonia in Alzheimer's disease: a case report and literature review of dystonia due to cholinesterase inhibitors.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dystonia; Female; Humans; Indans; Piperidines; Postural Balance | 2014 |
[Programs for continuing medical education: a session; 3. Dementia: diagnosis and therapy].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Cholinesterase Inhibitors; Cognitive Dysfunction; Dementia; Disease Progression; Donepezil; Education, Medical, Continuing; Galantamine; Humans; Indans; Lewy Body Disease; Nootropic Agents; Peptide Fragments; Phenylcarbamates; Piperidines; Positron-Emission Tomography; Reference Standards; Rivastigmine; tau Proteins; Tomography, Emission-Computed, Single-Photon | 2014 |
Changes in gait variability with anti-dementia drugs: a systematic review and meta-analysis.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Gait; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Piperidines | 2014 |
[Memory-enhancing drugs].
Topics: Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cyclic AMP Response Element-Binding Protein; Donepezil; Drug Discovery; Extracellular Signal-Regulated MAP Kinases; Galantamine; Hippocampus; Humans; Indans; Long-Term Potentiation; Memantine; Memory; Memory Disorders; Molecular Targeted Therapy; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Synaptic Transmission | 2014 |
[Progress of dementia medicine: Special reference to Alzheimer's disease].
Topics: Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Galantamine; Humans; Indans; Magnetic Resonance Imaging; Memantine; Neurofibrillary Tangles; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Tomography, Emission-Computed, Single-Photon | 2014 |
[Treatment of cognitive impairments in oncology: a review of longitudinal controlled studies].
Topics: Adult; Benzhydryl Compounds; Case-Control Studies; Central Nervous System Stimulants; Cognition; Cognition Disorders; Darbepoetin alfa; Donepezil; Erythropoietin; Estradiol; Executive Function; Female; Humans; Indans; Longitudinal Studies; Male; Meditation; Methylphenidate; Modafinil; Neoplasms; Piperidines | 2014 |
Developing interventions for cancer-related cognitive dysfunction in childhood cancer survivors.
Topics: Adolescent; Adult; Age Factors; Antimetabolites, Antineoplastic; Attention; Benzhydryl Compounds; Brain Neoplasms; Central Nervous System Stimulants; Child; Child, Preschool; Cognitive Dysfunction; Comorbidity; Cranial Irradiation; Donepezil; Early Intervention, Educational; Education, Special; Head and Neck Neoplasms; Human Growth Hormone; Humans; Indans; Infant; Injections, Spinal; Memory, Short-Term; Methotrexate; Methylphenidate; Modafinil; Neoplasms; Neurosurgical Procedures; Nootropic Agents; Patient Education as Topic; Piperidines; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psychomotor Performance; Quality of Life; Radiotherapy Dosage; Risk Factors; Severity of Illness Index; Sex Factors; Survivors; Thinking; Wakefulness-Promoting Agents; Young Adult | 2014 |
Understanding the beneficial and detrimental effects of donepezil and rivastigmine to improve their therapeutic value.
Topics: Acetylcholine; Acetylcholinesterase; Amyloid beta-Peptides; Apolipoproteins E; Butyrylcholinesterase; Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Microglia; Phenylcarbamates; Piperidines; Rivastigmine | 2015 |
Improving the predictive value of interventional animal models data.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Data Mining; Databases, Factual; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Exercise Therapy; Humans; Indans; Memantine; Piperidines; Species Specificity; Systems Biology; Systems Integration; Translational Research, Biomedical | 2015 |
Interventions for preventing and ameliorating cognitive deficits in adults treated with cranial irradiation.
Topics: Adult; Benzhydryl Compounds; Cognition Disorders; Cranial Irradiation; Donepezil; Humans; Indans; Memantine; Methylphenidate; Modafinil; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2014 |
Donepezil across the spectrum of Alzheimer's disease: dose optimization and clinical relevance.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Piperidines | 2015 |
Activation of sigma-1 receptor chaperone in the treatment of neuropsychiatric diseases and its clinical implication.
Topics: Animals; Donepezil; Humans; Indans; Mental Disorders; Models, Neurological; Neurotransmitter Agents; Piperidines; Receptors, sigma; Selective Serotonin Reuptake Inhibitors; Sigma-1 Receptor | 2015 |
[Treatment of vascular dementia by Chinese herbal medicine: a systematic review of randomized controlled trials of clinical studies].
Topics: Complementary Therapies; Dementia, Vascular; Donepezil; Drugs, Chinese Herbal; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 2015 |
Current Practices in the Treatment of Alzheimer Disease: Where is the Evidence After the Phase III Trials?
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials, Phase III as Topic; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Piperidines; Rivastigmine; Treatment Outcome | 2015 |
Hypothesis of Endogenous Anticholinergic Activity in Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Memantine; Piperidines | 2015 |
Namzaric--a combination of 2 old drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Combinations; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2015 |
Drugs to Enhance Motor Recovery After Stroke.
Topics: Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Humans; Indans; Levodopa; Motor Activity; Motor Skills; Piperidines; Recovery of Function; Selective Serotonin Reuptake Inhibitors; Stroke; Stroke Rehabilitation | 2015 |
Upper gastrointestinal bleed associated with cholinesterase inhibitor use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Duodenal Ulcer; Endoscopy; Gastrointestinal Hemorrhage; Humans; Indans; Lansoprazole; Male; Piperidines; Proton Pump Inhibitors; Syncope | 2015 |
Effect of Genetic Polymorphisms (SNPs) in CHRNA7 Gene on Response to Acetylcholinesterase Inhibitors (AChEI) in Patients with Alzheimer's Disease.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gene Expression Regulation; Humans; Indans; Male; Pharmacogenomic Variants; Piperidines; Polymorphism, Single Nucleotide; Treatment Outcome; Up-Regulation | 2017 |
Pharmacological interventions for cognitive decline in people with Down syndrome.
Topics: Acetylcarnitine; Adult; Antioxidants; Cognition; Cognition Disorders; Donepezil; Down Syndrome; Humans; Indans; Memantine; Middle Aged; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Simvastatin | 2015 |
Exploring the role of donepezil in dementia with Lewy bodies.
Topics: Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Lewy Body Disease; Piperidines | 2015 |
Current Treatment Options for Alzheimer's Disease and Parkinson's Disease Dementia.
Topics: Alzheimer Disease; Animals; Antiparkinson Agents; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Exercise Therapy; Galantamine; Humans; Indans; Memantine; Parkinson Disease; Piperidines; Rivastigmine; Sleep Wake Disorders; Treatment Outcome | 2016 |
The comparative efficacy and safety of cholinesterase inhibitors in patients with mild-to-moderate Alzheimer's disease: a Bayesian network meta-analysis.
Topics: Aged; Alzheimer Disease; Bayes Theorem; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Galantamine; Humans; Indans; Male; Middle Aged; Network Meta-Analysis; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2016 |
Role of Donepezil in the Management of Neuropsychiatric Symptoms in Alzheimer's Disease and Dementia with Lewy Bodies.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Lewy Body Disease; Piperidines; Psychotic Disorders | 2016 |
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Ligands; Piperidines; Tacrine | 2017 |
Promising Therapies for Alzheimer's Disease.
Topics: Allosteric Regulation; Alzheimer Disease; Animals; Donepezil; Humans; Indans; Ligands; Neuroprotective Agents; Piperidines; Receptors, Cholinergic; Rivastigmine | 2016 |
Efficacy of Cholinesterase Inhibitors in Vascular Dementia: An Updated Meta-Analysis.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Female; Galantamine; Humans; Indans; Neuropsychological Tests; Piperidines; Rivastigmine | 2016 |
Medical Therapies of Amblyopia: Translational Research to Expand Our Treatment Armamentarium.
Topics: Amblyopia; Carbidopa; Cholinesterase Inhibitors; Donepezil; Dopamine Agonists; Drug Combinations; Fluoxetine; Humans; Indans; Levodopa; Neuronal Plasticity; Piperidines; Selective Serotonin Reuptake Inhibitors; Translational Research, Biomedical; Visual Cortex | 2016 |
Acetylcholinesterase inhibitors and memantine in bipolar disorder: A systematic review and best evidence synthesis of the efficacy and safety for multiple disease dimensions.
Topics: Adult; Bipolar Disorder; Case-Control Studies; Cholinesterase Inhibitors; Clinical Trials as Topic; Depression; Depressive Disorder; Donepezil; Evidence-Based Medicine; Excitatory Amino Acid Antagonists; Female; Galantamine; Humans; Indans; Male; Memantine; Middle Aged; Piperidines; Psychotic Disorders; Randomized Controlled Trials as Topic; Treatment Outcome | 2016 |
Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Galantamine; Humans; Indans; Molecular Targeted Therapy; Piperidines; Rivastigmine; Structure-Activity Relationship | 2016 |
Psychopharmacological Studies in Mice.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dopamine; Drug Discovery; Environment; Female; Galantamine; Indans; Male; Mental Disorders; Mice; Molecular Targeted Therapy; Motivation; Piperidines; Psychopharmacology; Rats; Receptor, Serotonin, 5-HT1A; Receptor, Serotonin, 5-HT1D; Receptors, Dopamine D2; Research; Rivastigmine | 2016 |
Memantine and donepezil: a fixed drug combination for the treatment of moderate to severe Alzheimer's dementia.
Topics: Alzheimer Disease; Donepezil; Drug Therapy, Combination; Humans; Indans; Memantine; Piperidines; Practice Guidelines as Topic | 2016 |
Effect of the CYP2D6 and APOE Polymorphisms on the Efficacy of Donepezil in Patients with Alzheimer's Disease: A Systematic Review and Meta-Analysis.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Cytochrome P-450 CYP2D6; Donepezil; Humans; Indans; Nootropic Agents; Pharmacogenetics; Piperidines; Polymorphism, Single Nucleotide | 2016 |
Pharmacotherapeutic strategies in the treatment of severe Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Transdermal Patch | 2016 |
A fixed-dose combination of memantine extended-release and donepezil in the treatment of moderate-to-severe Alzheimer's disease.
Topics: Adolescent; Adult; Alzheimer Disease; Biological Availability; Cholinesterase Inhibitors; Cognition; Delayed-Action Preparations; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Memantine; Middle Aged; Nootropic Agents; Piperidines; Severity of Illness Index; Young Adult | 2016 |
Pharmacotherapies for Parkinson's disease symptoms related to cholinergic degeneration.
Topics: Animals; Cholinergic Agents; Cholinergic Neurons; Clinical Trials as Topic; Cognition Disorders; Dementia; Donepezil; Gait; Humans; Indans; Nerve Degeneration; Parkinson Disease; Piperidines; Psychotic Disorders | 2016 |
Recent Highlights on Molecular Hybrids Potentially Useful in Central Nervous System Disorders.
Topics: Analgesics; Central Nervous System Diseases; Choline; Donepezil; Epilepsy; gamma-Aminobutyric Acid; Humans; Indans; Opioid Peptides; Pain; Piperidines; Tacrine | 2017 |
Alzheimer's disease in the zebrafish: where can we take it?
Topics: Alzheimer Disease; Animals; Dementia; Disease Models, Animal; Donepezil; Humans; Indans; Memantine; Methylene Blue; Piperidines; Rodentia; Species Specificity; Zebrafish | 2017 |
Alzheimer Disease: Monotherapy vs. Combination Therapy.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Drug Therapy, Combination; Galantamine; Humans; Indans; Memantine; Piperidines; Rivastigmine | 2017 |
Acetylcholinesterase inhibitors for treating dementia symptoms - a safety evaluation.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Drug Interactions; Galantamine; Humans; Indans; Piperidines; Rivastigmine; Severity of Illness Index | 2017 |
Treatment effects between monotherapy of donepezil versus combination with memantine for Alzheimer disease: A meta-analysis.
Topics: Alzheimer Disease; Donepezil; Drug Therapy, Combination; Humans; Indans; Memantine; Nootropic Agents; Piperidines | 2017 |
Beyond symptomatic effects: potential of donepezil as a neuroprotective agent and disease modifier in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Disease Progression; Donepezil; Early Diagnosis; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Piperidines; Time Factors | 2017 |
Advances toward multifunctional cholinesterase and β-amyloid aggregation inhibitors.
Topics: Alkaloids; Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Humans; Indans; Inhibitory Concentration 50; Piperidines; Rivastigmine; Tacrine | 2017 |
Pharmacological treatment for memory disorder in multiple sclerosis.
Topics: Adult; Donepezil; Ginkgo biloba; Humans; Indans; Memantine; Memory Disorders; Multiple Sclerosis; Neuroprotective Agents; Nootropic Agents; Phytotherapy; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2017 |
Comparisons between traditional medicines and pharmacotherapies for Alzheimer disease: A systematic review and meta-analysis of cognitive outcomes.
Topics: Alzheimer Disease; Asia, Eastern; Cholinesterase Inhibitors; Cognition; Donepezil; Galantamine; Humans; Indans; Medicine, Traditional; Memantine; Nootropic Agents; Piperidines; Plant Extracts; Rivastigmine | 2018 |
Profiling donepezil template into multipotent hybrids with antioxidant properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Molecular Structure; Piperidines; Structure-Activity Relationship | 2018 |
Donepezil for dementia due to Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2018 |
The efficacy and safety of memantine for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Piperidines; Randomized Controlled Trials as Topic | 2018 |
Donepezil-based multi-functional cholinesterase inhibitors for treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Discovery; Humans; Indans; Ligands; Molecular Docking Simulation; Oxidative Stress; Piperidines | 2018 |
[The use of donepezil in gait disorders in eldery patients with dementia].
Topics: Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Gait; Gait Disorders, Neurologic; Humans; Indans; Piperidines | 2019 |
Enhancing Therapeutic Efficacy of Donepezil by Combined Therapy: A Comprehensive Review.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2021 |
Alzheimer's Disease: Efficacy of Mono- and Combination Therapy. A Systematic Review.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Humans; Indans; Memantine; Piperidines | 2022 |
The association of changes of sleep architecture related to donepezil: A systematic review and meta-analysis.
Topics: Donepezil; Humans; Indans; Piperidines; Polysomnography; Sleep | 2022 |
Compared of efficacy and safety of high-dose donepezil vs standard-dose donepezil among elderly patients with Alzheimer's disease: a systematic review and meta-analysis.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2022 |
Acetylcholinesterase inhibitors to enhance recovery from traumatic brain injury: a comprehensive review and case series.
Topics: Acetylcholinesterase; Adult; Brain Injuries, Traumatic; Child; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Piperidines; Rivastigmine | 2022 |
Challenges and Approaches of Drugs Such as Memantine, Donepezil, Rivastigmine, and Aducanumab in the Treatment, Control and Management of Alzheimer's Disease.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal, Humanized; Donepezil; Indans; Memantine; Patents as Topic; Piperidines; Rivastigmine | 2022 |
Personalized Prediction of Alzheimer's Disease and Its Treatment Effects by Donepezil: An Individual Participant Data Meta-Analysis of Eight Randomized Controlled Trials.
Topics: Alzheimer Disease; Antipsychotic Agents; Bayes Theorem; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 2022 |
460 trial(s) available for donepezil and piperidines
| Article | Year |
|---|---|
Comparison of the pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy young and elderly subjects.
Topics: Administration, Oral; Adult; Aged; Aging; Alzheimer Disease; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Female; Half-Life; Humans; Indans; Male; Metabolic Clearance Rate; Piperidines; Protein Binding | 1993 |
Pharmacokinetics of E2020, a new compound for Alzheimer's disease, in healthy male volunteers.
Topics: Adult; Alzheimer Disease; Blood Proteins; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Food; Humans; Indans; Male; Piperidines; Protein Binding; Single-Blind Method; Spectrophotometry, Ultraviolet | 1993 |
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory; Mental Status Schedule; Piperidines | 1998 |
Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: an interim analysis of the results of a US multicentre open label extension study.
Topics: Adult; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Psychiatric Status Rating Scales; United States | 1998 |
Donepezil improves cognition and global function in Alzheimer disease: a 15-week, double-blind, placebo-controlled study. Donepezil Study Group.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Piperidines; Treatment Outcome; United States | 1998 |
Donepezil for treatment of dementia with Lewy bodies: a case series of nine patients.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Dementia; Donepezil; Female; Geriatric Assessment; Humans; Indans; Lewy Bodies; Male; Mental Status Schedule; Nootropic Agents; Parkinson Disease, Secondary; Piperidines | 1998 |
Pharmacokinetic and pharmacodynamic profile of donepezil HCl following single oral doses.
Topics: Administration, Oral; Adult; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Indans; Male; Piperidines | 1998 |
Pharmacokinetic and pharmacodynamic profile of donepezil HCl following multiple oral doses.
Topics: Administration, Oral; Adult; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Indans; Male; Piperidines | 1998 |
Pharmacokinetic and pharmacodynamic profile of donepezil HCl following evening administration.
Topics: Administration, Oral; Adult; Analysis of Variance; Blood Proteins; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Piperidines | 1998 |
Metabolism and elimination of 14C-donepezil in healthy volunteers: a single-dose study.
Topics: Administration, Oral; Adult; Carbon Radioisotopes; Cholinesterase Inhibitors; Donepezil; Feces; Humans; Indans; Male; Metabolic Clearance Rate; Middle Aged; Piperidines | 1998 |
Concurrent administration of donepezil HCl and cimetidine: assessment of pharmacokinetic changes following single and multiple doses.
Topics: Administration, Oral; Adult; Cholinesterase Inhibitors; Cimetidine; Cross-Over Studies; Donepezil; Drug Interactions; Histamine H2 Antagonists; Humans; Indans; Male; Middle Aged; Piperidines | 1998 |
Concurrent administration of donepezil HCl and ketoconazole: assessment of pharmacokinetic changes following single and multiple doses.
Topics: Administration, Oral; Adult; Antifungal Agents; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indans; Ketoconazole; Male; Middle Aged; Piperidines | 1998 |
Concurrent administration of donepezil HCl and theophylline: assessment of pharmacokinetic changes following multiple-dose administration in healthy volunteers.
Topics: Administration, Oral; Adult; Bronchodilator Agents; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Drug Interactions; Humans; Indans; Male; Piperidines; Theophylline | 1998 |
Concurrent administration of donepezil HCl and digoxin: assessment of pharmacokinetic changes.
Topics: Administration, Oral; Adult; Cardiotonic Agents; Cholinesterase Inhibitors; Cross-Over Studies; Digoxin; Donepezil; Drug Interactions; Humans; Indans; Male; Piperidines | 1998 |
The effect of multiple doses of donepezil HCl on the pharmacokinetic and pharmacodynamic profile of warfarin.
Topics: Administration, Oral; Adolescent; Adult; Analysis of Variance; Anticoagulants; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Drug Interactions; Humans; Indans; Male; Middle Aged; Piperidines; Warfarin | 1998 |
An evaluation of the pharmacokinetics of donepezil HCl in patients with impaired hepatic function.
Topics: Administration, Oral; Adult; Aged; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Liver Cirrhosis; Male; Middle Aged; Piperidines | 1998 |
An evaluation of the pharmacokinetics of donepezil HCl in patients with moderately to severely impaired renal function.
Topics: Administration, Oral; Adult; Aged; Analysis of Variance; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Kidney Diseases; Male; Middle Aged; Piperidines | 1998 |
Clinical experience with Donepezil (Aricept) in the UK.
Topics: Alzheimer Disease; Clinical Protocols; Donepezil; Double-Blind Method; Humans; Indans; Licensure, Pharmacy; Nootropic Agents; Patient Selection; Piperidines; United Kingdom | 1998 |
First International Pharmacoeconomic Conference on Alzheimer's Disease: report and summary.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Humans; Indans; Middle Aged; Models, Economic; Neuroprotective Agents; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Selegiline | 1998 |
Cholinergic therapy for Down's syndrome.
Topics: Adaptation, Psychological; Adult; Cholinesterase Inhibitors; Dementia; Donepezil; Down Syndrome; Drug Administration Schedule; Female; Humans; Indans; Intelligence Tests; Male; Middle Aged; Piperidines; Treatment Outcome | 1999 |
Is donepezil effective for treating Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Piperidines; Quality of Life; Treatment Outcome | 1999 |
Donepezil in treatment-resistant bipolar disorder.
Topics: Adult; Bipolar Disorder; Cholinesterase Inhibitors; Donepezil; Drug Resistance; Female; Humans; Indans; Male; Middle Aged; Pilot Projects; Piperidines; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 1999 |
Defining meaningful change in Alzheimer's disease trials: the donepezil experience.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Dose-Response Relationship, Drug; Guidelines as Topic; Humans; Indans; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 1999 |
The effects of donepezil on the P300 auditory and visual cognitive evoked potentials of patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Event-Related Potentials, P300; Evoked Potentials, Auditory; Evoked Potentials, Visual; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Refractory Period, Electrophysiological | 1999 |
Donepezil for psychotropic-induced memory loss.
Topics: Adult; Ambulatory Care; Cholinesterase Inhibitors; Constipation; Depressive Disorder; Diarrhea; Dizziness; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Memory Disorders; Middle Aged; Piperidines; Psychotropic Drugs; Sleep Initiation and Maintenance Disorders; Xerostomia | 1999 |
Donepezil for Huntington's disease.
Topics: Adult; Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Huntington Disease; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines | 2000 |
Donepezil therapy in clinical practice: a randomized crossover study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2000 |
Changes in the rCBF images of patients with Alzheimer's disease receiving Donepezil therapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Donepezil; Female; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Nootropic Agents; Piperidines; Radiopharmaceuticals; Retrospective Studies; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2000 |
Long-term efficacy and safety of donepezil in the treatment of Alzheimer's disease: final analysis of a US multicentre open-label study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; United States | 2000 |
A 12-week, open trial of donepezil hydrochloride in patients with multiple sclerosis and associated cognitive impairments.
Topics: Adult; Aged; Attention; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Middle Aged; Multiple Sclerosis; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Verbal Learning | 2000 |
Effects of donepezil on emotional/behavioral symptoms in Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2000 |
Donepezil in Alzheimer's disease: eighteen month results from Southampton Memory Clinic.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Donepezil; Dose-Response Relationship, Drug; England; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 2000 |
Better cognitive and psychopathologic response to donepezil in patients prospectively diagnosed as dementia with Lewy bodies: a preliminary study.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Electromyography; Female; Humans; Indans; Lewy Body Disease; Male; Middle Aged; Motor Skills Disorders; Piperidines; Prospective Studies; Treatment Outcome | 2000 |
Differential increase in cerebrospinal fluid-acetylcholinesterase after treatment with acetylcholinesterase inhibitors in patients with Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Biomarkers; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Galantamine; Humans; Indans; Male; Middle Aged; Piperidines | 2001 |
Donepezil in the treatment of progressive supranuclear palsy.
Topics: Aged; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Severity of Illness Index; Supranuclear Palsy, Progressive | 2001 |
Open-label, multicenter, phase 3 extension study of the safety and efficacy of donepezil in patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Treatment Outcome | 2001 |
Amyloid precursor protein in platelets of patients with Alzheimer disease: effect of acetylcholinesterase inhibitor treatment.
Topics: Aged; Alzheimer Disease; Amyloid beta-Protein Precursor; Blood Platelets; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Piperidines | 2001 |
A double-blind placebo-controlled case study of the use of donepezil to improve cognition in a schizoaffective disorder patient: functional MRI correlates.
Topics: Adult; Basal Ganglia; Benzodiazepines; Brain; Brain Mapping; Cognition Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Therapy, Combination; Humans; Indans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Olanzapine; Piperidines; Pirenzepine; Prefrontal Cortex; Psychiatric Status Rating Scales; Psychotic Disorders; Quality of Life | 2001 |
Open-label study of donepezil in traumatic brain injury.
Topics: Adult; Brain Injuries; Chronic Disease; Donepezil; Humans; Indans; Male; Memory Disorders; Mental Disorders; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2001 |
Cholinergic modulation of speed of early information processing: the effect of donepezil on inspection time.
Topics: Adult; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Mental Processes; Parasympathetic Nervous System; Piperidines; Psychomotor Performance | 2001 |
Randomized placebo-controlled trial of donepezil in patients with progressive supranuclear palsy.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Quality of Life; Supranuclear Palsy, Progressive | 2001 |
A 1-year, placebo-controlled preservation of function survival study of donepezil in AD patients.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Time Factors | 2001 |
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Piperidines; Time Factors | 2001 |
A 24-week, randomized, double-blind study of donepezil in moderate to severe Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Least-Squares Analysis; Male; Middle Aged; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2001 |
Donepezil hydrochloride preserves regional cerebral blood flow in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Humans; Image Processing, Computer-Assisted; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Tomography, Emission-Computed, Single-Photon | 2001 |
Atrophy of the substantia innominata on magnetic resonance imaging and response to donepezil treatment in Alzheimer's disease.
Topics: Acetylcholine; Aged; Alzheimer Disease; Atrophy; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Neurons; Patient Selection; Piperidines; Predictive Value of Tests; Substantia Innominata; Treatment Outcome | 2002 |
A randomized, double-blind, placebo-controlled study of the efficacy and safety of donepezil in patients with Alzheimer's disease in the nursing home setting.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nursing Homes; Outcome Assessment, Health Care; Piperidines; Psychiatric Status Rating Scales; Severity of Illness Index | 2001 |
Comparison of citalopram, perphenazine, and placebo for the acute treatment of psychosis and behavioral disturbances in hospitalized, demented patients.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Behavioral Symptoms; Citalopram; Dementia; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Hospitalization; Humans; Indans; Male; Perphenazine; Piperidines; Placebos; Psychotic Disorders; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2002 |
A double blind placebo controlled trial of donepezil adjunctive treatment to risperidone for the cognitive impairment of schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Risperidone; Schizophrenia; Schizophrenic Psychology | 2002 |
A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Down syndrome and Alzheimer's disease--pilot study.
Topics: Adult; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Comorbidity; Donepezil; Double-Blind Method; Down Syndrome; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Pilot Projects; Piperidines; Treatment Outcome | 2002 |
Donepezil for cognitive impairment in Parkinson's disease: a randomised controlled study.
Topics: Administration, Oral; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition Disorders; Cross-Over Studies; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Parkinson Disease; Piperidines; Treatment Outcome | 2002 |
The effects of donepezil on quantitative EEG in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Humans; Indans; Male; Piperidines; Reproducibility of Results; Sensitivity and Specificity | 2002 |
Efficacy and safety of rivastigmine in patients with Alzheimer's disease who failed to benefit from treatment with donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine; Severity of Illness Index; Treatment Failure; Treatment Outcome | 2002 |
Donepezil and flight simulator performance: effects on retention of complex skills.
Topics: Adult; Aged; Aging; Aviation; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Humans; Indans; Middle Aged; Motor Skills; Piperidines; Psychomotor Performance | 2002 |
Donepezil in the treatment of hallucinations and delusions in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Basal Nucleus of Meynert; Cholinergic Fibers; Cholinesterase Inhibitors; Delusions; Donepezil; Female; Hallucinations; Humans; Indans; Male; Movement; Parkinson Disease; Piperidines; Sexual Dysfunctions, Psychological; Sleep Wake Disorders; Treatment Outcome | 2002 |
Down syndrome and Alzheimer disease: response to donepezil.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Down Syndrome; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Pilot Projects; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2002 |
Effects of long-term Donepezil therapy on rCBF of Alzheimer's patients.
Topics: Aged; Alzheimer Disease; Brain; Brain Mapping; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Regional Blood Flow; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2002 |
Presence or absence of at least one epsilon 4 allele and gender are not predictive for the response to donepezil treatment in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Donepezil; Educational Status; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Predictive Value of Tests; Sex Characteristics | 2002 |
An N-of-1 randomized controlled trial ('N-of-1 trial') of donepezil in the treatment of non-progressive amnestic syndrome.
Topics: Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Indans; Memory, Short-Term; Piperidines | 2002 |
Donepezil for cognitive impairment in Parkinson's disease: a randomized controlled trial.
Topics: Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Parkinson Disease; Piperidines; Treatment Outcome | 2002 |
Correlates of dropout, efficacy, and adverse events in treatment with acetylcholinesterase inhibitors in Korean patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Patient Dropouts; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine | 2002 |
Goal setting and attainment in Alzheimer's disease patients treated with donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Goals; Humans; Indans; Interpersonal Relations; Male; Neuropsychological Tests; Piperidines; Professional-Patient Relations; Prospective Studies; Psychometrics; Severity of Illness Index | 2002 |
An open-labeled trial of adjunctive donepezil for cognitive impairments in patients with schizophrenia.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Cognition Disorders; Donepezil; Drug Therapy, Combination; Evoked Potentials; Female; Humans; Indans; Male; Memory; Nootropic Agents; Olanzapine; Pilot Projects; Piperidines; Pirenzepine; Schizophrenia | 2003 |
Patient populations in clinical trials of the efficacy and tolerability of donepezil in patients with vascular dementia.
Topics: Aged; Brain; Cerebrovascular Circulation; Cognition; Cohort Studies; Dementia, Vascular; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychometrics; Research Design; Risk Factors | 2002 |
Treatment with donepezil in Alzheimer patients with and without cerebrovascular disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Disorders; Donepezil; Female; Germany; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Quality of Life | 2002 |
Functional, cognitive and behavioral effects of donepezil in patients with moderate Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Behavior; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index | 2002 |
Regional effects of donepezil and rivastigmine on cortical acetylcholinesterase activity in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Frontal Lobe; Humans; Indans; Magnetic Resonance Imaging; Male; Parietal Lobe; Phenylcarbamates; Piperidines; Reproducibility of Results; Rivastigmine; Temporal Lobe; Tomography, Emission-Computed | 2002 |
An economic evaluation of donepezil in mild to moderate Alzheimer's disease: results of a 1-year, double-blind, randomized trial.
Topics: Aged; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cost of Illness; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Severity of Illness Index; Treatment Outcome | 2003 |
Donepezil-treated patients with probable vascular dementia demonstrate cognitive benefits.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Patient Selection; Piperidines; Time Factors | 2002 |
Donepezil for the treatment of language deficits in adults with Down syndrome: a preliminary 24-week open trial.
Topics: Adult; Appetite; Cholinesterase Inhibitors; Diarrhea; Donepezil; Dose-Response Relationship, Drug; Down Syndrome; Female; Follow-Up Studies; Humans; Hypotension; Indans; Language Disorders; Language Tests; Male; Muscle Cramp; Nausea; Piperidines; Treatment Outcome | 2003 |
Cerebrospinal fluid levels of biomarkers and activity of acetylcholinesterase (AChE) and butyrylcholinesterase in AD patients before and after treatment with different AChE inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Enzyme-Linked Immunosorbent Assay; Galantamine; Humans; Indans; Peptide Fragments; Phenylcarbamates; Phosphorylation; Piperidines; Rivastigmine; tau Proteins | 2002 |
Acetylcholine muscarinic receptors and response to anti-cholinesterase therapy in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Quinuclidinyl Benzilate; Radionuclide Imaging; Radiopharmaceuticals; Receptor, Muscarinic M1; Receptors, Muscarinic; Reproducibility of Results; Sensitivity and Specificity; Statistics as Topic; Technetium Tc 99m Exametazime; Tissue Distribution; Treatment Outcome | 2003 |
Pharmacokinetic and safety assessments of concurrent administration of risperidone and donepezil.
Topics: Adult; Area Under Curve; Biological Availability; Cross-Over Studies; Donepezil; Drug Interactions; Humans; Indans; Male; Piperidines; Risperidone | 2003 |
Regional cerebral blood flow patterns and response to donepezil treatment in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Indans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2003 |
Cardiovascular effects of donepezil in patients with dementia.
Topics: Aged; Autonomic Nervous System; Cardiovascular System; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Heart Rate; Humans; Indans; Male; Pilot Projects; Piperidines; Regression Analysis; Sampling Studies; Syncope | 2003 |
Kinematic analysis of the effects of donepezil hydrochloride on hand motor function in patients with Alzheimer dementia.
Topics: Alzheimer Disease; Biomechanical Phenomena; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Hand; Handwriting; Humans; Indans; Male; Motor Activity; Piperidines | 2003 |
Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Anxiety; Arousal; Depression; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Nootropic Agents; Piperidines; Social Behavior Disorders; Treatment Outcome | 2002 |
A large, community-based, open-label trial of donepezil in the treatment of Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antidepressive Agents; Aspirin; Cholinesterase Inhibitors; Comorbidity; Donepezil; Female; Gastrointestinal Diseases; Humans; Indans; Male; Middle Aged; Piperidines; Risk Assessment; Vitamins | 2003 |
Efficacy of donepezil on maintenance of activities of daily living in patients with moderate to severe Alzheimer's disease and the effect on caregiver burden.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cost of Illness; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Social Behavior; Stress, Physiological; Time Factors; Treatment Outcome | 2003 |
The clinical use of P300 event related potentials for the evaluation of cholinesterase inhibitors treatment in demented patients.
Topics: Acetylcholine; Aged; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Electroencephalography; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Prospective Studies; Reaction Time; Rivastigmine; Tacrine; Treatment Outcome | 2003 |
Serum cholesterol levels modulate long-term efficacy of cholinesterase inhibitors in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Carbamates; Cholesterol; Cholinesterase Inhibitors; Disease Progression; Donepezil; Female; Genotype; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2003 |
Psychoactive drugs and pilot performance: a comparison of nicotine, donepezil, and alcohol effects.
Topics: Adult; Aircraft; Area Under Curve; Central Nervous System Depressants; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Ethanol; Female; Humans; Indans; Male; Middle Aged; Motor Skills; Nicotine; Nicotinic Agonists; Piperidines; Psychomotor Performance; Psychotropic Drugs; Space Simulation; Time Factors | 2003 |
Long term safety and efficacy of donepezil in the treatment of dementia in Alzheimer's disease in adults with Down syndrome: open label study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Down Syndrome; Humans; Indans; Long-Term Care; Middle Aged; Neuropsychological Tests; Piperidines | 2003 |
Donepezil is associated with delayed nursing home placement in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Indans; Institutionalization; Male; Nursing Homes; Piperidines; Severity of Illness Index; Time Factors | 2003 |
Effects of acetyl-L-carnitine in Alzheimer's disease patients unresponsive to acetylcholinesterase inhibitors.
Topics: Acetylcarnitine; Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Nootropic Agents; Phenylcarbamates; Pilot Projects; Piperidines; Rivastigmine | 2003 |
A long-term comparison of galantamine and donepezil in the treatment of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cognition; Donepezil; Drug Administration Schedule; Female; Galantamine; Humans; Indans; Male; Mental Status Schedule; Piperidines; Time; Treatment Outcome | 2003 |
Augmenting atypical antipsychotics with a cognitive enhancer (donepezil) improves regional brain activity in schizophrenia patients: a pilot double-blind placebo controlled BOLD fMRI study.
Topics: Adult; Antipsychotic Agents; Cholinesterase Inhibitors; Cognition Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Therapy, Combination; Humans; Indans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Outpatients; Piperidines; Placebos; Schizophrenia; Treatment Outcome | 2003 |
An open-label trial of donepezil (aricept) in the treatment of persons with mild traumatic brain injury.
Topics: Adult; Brain Injury, Chronic; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Intelligence Tests; Male; Middle Aged; Neuropsychological Tests; Pilot Projects; Piperidines | 2003 |
Donepezil in vascular dementia: a randomized, placebo-controlled study.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Double-Blind Method; Female; Heart Diseases; Humans; Hypercholesterolemia; Hypertension; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Risk Factors; Smoking; Stroke; Treatment Outcome | 2003 |
[Bioequivalence of donepezil capsule and tablet in human].
Topics: Adult; Area Under Curve; Biological Availability; Capsules; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cross-Over Studies; Donepezil; Humans; Indans; Male; Piperidines; Spectrometry, Mass, Electrospray Ionization; Tablets; Therapeutic Equivalency | 2003 |
Efficacy and tolerability of donepezil in vascular dementia: positive results of a 24-week, multicenter, international, randomized, placebo-controlled clinical trial.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Cardiovascular System; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Diarrhea; Donepezil; Double-Blind Method; Female; Headache; Humans; Indans; Internationality; Male; Middle Aged; Nausea; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2003 |
Effects of donepezil on cognitive functioning in Down syndrome.
Topics: Adolescent; Adult; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Down Syndrome; Drug Administration Schedule; Female; Humans; Indans; Language Development Disorders; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2003 |
The effect of donepezil on sedation and other symptoms in patients receiving opioids for cancer pain: a pilot study.
Topics: Adult; Aged; Analgesics, Opioid; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neoplasms; Nootropic Agents; Pain; Pilot Projects; Piperidines; Prospective Studies; Sleep Stages | 2003 |
Randomized, placebo-controlled trial of the effects of donepezil on neuronal markers and hippocampal volumes in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Aspartic Acid; Biomarkers; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Neurons; Piperidines; Placebos; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 2003 |
A randomised placebo controlled study to assess the effects of cholinergic treatment on muscarinic receptors in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Iodine Radioisotopes; Male; Middle Aged; Muscarinic Antagonists; Piperidines; Placebos; Psychometrics; Quinuclidinyl Benzilate; Sensitivity and Specificity; Severity of Illness Index; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2003 |
What happens when donepezil is suddenly withdrawn? An open label trial in dementia with Lewy bodies and Parkinson's disease with dementia.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Drug Administration Schedule; Humans; Indans; Lewy Body Disease; Neuropsychological Tests; Nootropic Agents; Parkinson Disease; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2003 |
Short-term effects of acetylcholinesterase inhibitor treatment on EEG and memory performance in Alzheimer patients: an open, controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Humans; Indans; Male; Memory; Memory Disorders; Middle Aged; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Theta Rhythm; Time Factors; Treatment Outcome | 2003 |
Quantitative EEG and perfusional single photon emission computed tomography correlation during long-term donepezil therapy in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Donepezil; Electroencephalography; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Radiopharmaceuticals; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon | 2004 |
Randomized placebo-controlled trial of donepezil in cognitive impairment in Parkinson's disease.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Parkinson Disease; Pilot Projects; Piperidines; Treatment Outcome | 2004 |
A randomized, placebo-controlled study of the efficacy and safety of sertraline in the treatment of the behavioral manifestations of Alzheimer's disease in outpatients treated with donepezil.
Topics: Aged; Alzheimer Disease; Ambulatory Care; Antidepressive Agents; Behavioral Symptoms; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 2004 |
A multinational, randomised, 12-week study comparing the effects of donepezil and galantamine in patients with mild to moderate Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Attitude of Health Personnel; Attitude to Health; Caregivers; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Galantamine; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Treatment Outcome | 2004 |
Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Male; Memantine; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index | 2004 |
A double-blind, placebo controlled, cross-over trial of adjunctive donepezil for cognitive impairment in schizophrenia.
Topics: Adult; Cognition Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 2004 |
Donepezil for Alzheimer's disease in clinical practice--The DONALD Study. A multicenter 24-week clinical trial in Germany.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cardiovascular Diseases; Cholinesterase Inhibitors; Donepezil; Electrocardiography; Female; Germany; Hemodynamics; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2004 |
Effects of cholinergic drugs and cognitive training on dementia.
Topics: Aged; Aging; Alzheimer Disease; Cholinergic Agents; Cognition; Cognitive Behavioral Therapy; Combined Modality Therapy; Dementia; Donepezil; Female; Humans; Indans; Long-Term Care; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Sex Characteristics | 2004 |
Neuropsychological test performance in healthy volunteers before and after donepezil administration.
Topics: Adult; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines | 2004 |
Alzheimer patients treated with an AchE inhibitor show higher IL-4 and lower IL-1 beta levels and expression in peripheral blood mononuclear cells.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Interleukin-1; Interleukin-4; Leukocytes, Mononuclear; Male; Piperidines | 2004 |
Effectiveness and safety of cholinesterase inhibitors in elderly subjects with Alzheimer's disease: a "real world" study.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Galantamine; Humans; Indans; Male; Neuropsychological Tests; Phenylcarbamates; Piperidines; Rivastigmine; Severity of Illness Index | 2004 |
Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cost-Benefit Analysis; Disease Progression; Donepezil; Double-Blind Method; Female; Health Care Costs; Health Resources; Humans; Indans; Institutionalization; Male; Middle Aged; Piperidines; Treatment Outcome; United Kingdom | 2004 |
Cholinergic augmentation with donepezil enhances recovery in short-term memory and sustained attention after traumatic brain injury.
Topics: Adult; Attention; Brain Injuries; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory; Middle Aged; Neuropsychological Tests; Piperidines | 2004 |
Donepezil augmentation of clozapine monotherapy in schizophrenia patients: a double blind cross-over study.
Topics: Adult; Antipsychotic Agents; Cholinesterase Inhibitors; Clozapine; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Female; Humans; Indans; Male; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Treatment Outcome | 2004 |
Lack of pharmacokinetic or pharmacodynamic interaction between memantine and donepezil.
Topics: Acetylcholinesterase; Administration, Oral; Adolescent; Adult; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Male; Memantine; Piperidines | 2004 |
The efficacy of donepezil in the treatment of neuropsychiatric symptoms in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Nootropic Agents; Patient Dropouts; Piperidines; Severity of Illness Index; Treatment Outcome; Withholding Treatment | 2004 |
Impact of donepezil treatment for Alzheimer's disease on caregiver time.
Topics: Activities of Daily Living; Alzheimer Disease; Caregivers; Donepezil; Home Nursing; Humans; Indans; Nootropic Agents; Piperidines; Time Factors | 2004 |
Economic evaluation of donepezil in moderate to severe Alzheimer disease.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Ambulatory Care; Australia; Canada; Caregivers; Cholinesterase Inhibitors; Cost of Illness; Cost-Benefit Analysis; Counseling; Donepezil; Drug Costs; Female; France; Health Resources; Home Care Services; Home Nursing; Hospitalization; Humans; Indans; Institutionalization; Male; Middle Aged; Nootropic Agents; Nursing Homes; Piperidines; Prospective Studies; Surveys and Questionnaires | 2004 |
Efficacy of donepezil in mild cognitive impairment: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2004 |
Donepezil effects on language in children with Down syndrome: results of the first 22-week pilot clinical trial.
Topics: Adolescent; Child; Cholinesterase Inhibitors; Donepezil; Down Syndrome; Female; Humans; Indans; Language; Male; Nootropic Agents; Pilot Projects; Piperidines; Time Factors; Treatment Outcome; Verbal Behavior | 2004 |
Prediction of psychiatric response to donepezil in patients with mild to moderate Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Caregivers; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Mental Status Schedule; Neuropsychological Tests; Piperidines; Predictive Value of Tests; Regional Blood Flow; Retrospective Studies; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2004 |
Donepezil and vitamin E for preventing cognitive dysfunction in small cell lung cancer patients: preliminary results and suggestions for future study designs.
Topics: Aged; Antioxidants; Carcinoma, Small Cell; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Lung Neoplasms; Male; Piperidines; Vitamin E | 2005 |
Steady-state pharmacokinetics, pharmacodynamics and tolerability of donepezil hydrochloride in hepatically impaired patients.
Topics: Administration, Oral; Adolescent; Adult; Aged; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Liver Diseases; Male; Middle Aged; Piperidines | 2004 |
Steady-state pharmacokinetics and safety of donepezil HCl in subjects with moderately impaired renal function.
Topics: Adult; Aged; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Female; Humans; Indans; Kidney Diseases; Male; Middle Aged; Piperidines; Protein Binding | 2004 |
Concurrent administration of donepezil HCl and sertraline HCl in healthy volunteers: assessment of pharmacokinetic changes and safety following single and multiple oral doses.
Topics: Administration, Oral; Adult; Antidepressive Agents; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Drug Combinations; Drug Interactions; Female; Half-Life; Humans; Indans; Male; Middle Aged; Piperidines; Selective Serotonin Reuptake Inhibitors; Sertraline | 2004 |
Repeated dosing with donepezil does not affect the safety, tolerability or pharmacokinetics of single-dose thioridazine in young volunteers.
Topics: Adult; Antipsychotic Agents; Area Under Curve; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Drug Interactions; Female; Humans; Indans; Male; Piperidines; Thioridazine | 2004 |
Concurrent administration of donepezil HCl and levodopa/carbidopa in patients with Parkinson's disease: assessment of pharmacokinetic changes and safety following multiple oral doses.
Topics: Aged; Aged, 80 and over; Antiparkinson Agents; Carbidopa; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Combinations; Drug Interactions; Female; Humans; Indans; Levodopa; Male; Middle Aged; Parkinson Disease; Piperidines | 2004 |
Concurrent administration of donepezil HCl and risperidone in patients with schizophrenia: assessment of pharmacokinetic changes and safety following multiple oral doses.
Topics: Administration, Oral; Adult; Aged; Antipsychotic Agents; Area Under Curve; Cholinesterase Inhibitors; Donepezil; Drug Combinations; Drug Interactions; Humans; Indans; Male; Middle Aged; Piperidines; Risperidone; Schizophrenia | 2004 |
Donepezil improved memory in multiple sclerosis in a randomized clinical trial.
Topics: Adolescent; Adult; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Male; Memory; Middle Aged; Multiple Sclerosis; Nootropic Agents; Piperidines; Treatment Outcome | 2004 |
An open-label, comparative study of rivastigmine, donepezil and galantamine in a real-world setting.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Humans; Indans; Male; Mental Status Schedule; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2004 |
Donepezil as an adjuvant to constraint-induced therapy for upper-limb dysfunction after stroke: an exploratory randomized clinical trial.
Topics: Arm; Cholinesterase Inhibitors; Combined Modality Therapy; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Physical Therapy Modalities; Piperidines; Prospective Studies; Stroke; Stroke Rehabilitation | 2004 |
Efficacy of donepezil in early-stage Alzheimer disease: a randomized placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chi-Square Distribution; Donepezil; Double-Blind Method; Female; Gastrointestinal Diseases; Humans; Indans; Male; Middle Aged; Piperidines | 2004 |
Effects of donepezil on Alzheimer's disease: the relationship between cognitive function and rapid eye movement sleep.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Polysomnography; Psychiatric Status Rating Scales; Sleep; Sleep Wake Disorders; Sleep, REM | 2004 |
Effects of cognitive-communication stimulation for Alzheimer's disease patients treated with donepezil.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Behavior; Cholinesterase Inhibitors; Cognition; Cognitive Behavioral Therapy; Combined Modality Therapy; Communication; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Quality of Life; Treatment Outcome | 2004 |
Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Electromyography; Female; Humans; Indans; Male; Muscle Hypertonia; Nootropic Agents; Pilot Projects; Piperidines; Treatment Outcome; Urinary Incontinence; Urodynamics | 2005 |
Central acetylcholinesterase inhibitors in the treatment of chronic traumatic brain injury-clinical experience in 111 patients.
Topics: Adolescent; Adult; Aged; Brain Damage, Chronic; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Galantamine; Humans; Indans; Male; Middle Aged; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Psychomotor Performance; Rivastigmine; Treatment Outcome | 2005 |
Preliminary study of the relationship between thyroid status and cognitive and neuropsychiatric functioning in euthyroid patients with Alzheimer dementia.
Topics: Affective Symptoms; Aged; Alzheimer Disease; Cognition Disorders; Cross-Sectional Studies; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Statistics, Nonparametric; Thyroid Function Tests; Thyrotropin; Thyroxine | 2004 |
Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cognition Disorders; Cognitive Behavioral Therapy; Combined Modality Therapy; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Patient Satisfaction; Patients; Phenylcarbamates; Physical Therapy Modalities; Piperidines; Psychomotor Disorders; Rivastigmine; Single-Blind Method; Treatment Outcome | 2004 |
Differential efficacy of treatment with acetylcholinesterase inhibitors in patients with mild and moderate Alzheimer's disease over a 6-month period.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Female; Galantamine; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Piperidines; Prospective Studies; Retrospective Studies; Rivastigmine; Severity of Illness Index; Time Factors | 2005 |
Pharmacokinetics of donepezil in Down syndrome.
Topics: Adolescent; Adult; Donepezil; Down Syndrome; Humans; Indans; Male; Nootropic Agents; Piperidines | 2005 |
Degree of inhibition of cortical acetylcholinesterase activity and cognitive effects by donepezil treatment in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Attention; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Piperidines; Positron-Emission Tomography | 2005 |
A placebo-controlled screening trial of tiagabine, sertraline and donepezil as cocaine dependence treatments.
Topics: Adult; Anticonvulsants; Cocaine-Related Disorders; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nipecotic Acids; Piperidines; Selective Serotonin Reuptake Inhibitors; Sertraline; Tiagabine | 2005 |
Neuropsychological test performance in healthy elderly volunteers before and after donepezil administration: a randomized, controlled study.
Topics: Aged; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines | 2005 |
The age-related down-regulation of the growth hormone/insulin-like growth factor-1 axis in the elderly male is reversed considerably by donepezil, a drug for Alzheimer's disease.
Topics: Aged; Aging; Alzheimer Disease; Analysis of Variance; Area Under Curve; Cholinesterase Inhibitors; Donepezil; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Indans; Insulin-Like Growth Factor I; Male; Piperidines; Single-Blind Method | 2005 |
Added donepezil for stable schizophrenia: a double-blind, placebo-controlled trial.
Topics: Capsules; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Dyskinesias; Female; Humans; Indans; Male; Middle Aged; Piperidines; Placebos; Schizophrenia; Sialorrhea; Time Factors; Treatment Outcome | 2005 |
Does donepezil treatment slow the progression of hippocampal atrophy in patients with Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Atrophy; Cholinesterase Inhibitors; Cohort Studies; Disease Progression; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genotype; Geriatric Assessment; Hippocampus; Humans; Indans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Time Factors; Treatment Outcome | 2005 |
Vitamin E and donepezil for the treatment of mild cognitive impairment.
Topics: Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Double-Blind Method; Humans; Indans; Nootropic Agents; Piperidines; Proportional Hazards Models; Treatment Failure; Vitamin E | 2005 |
Do vascular lesions and related risk factors influence responsiveness to donepezil chloride in patients with Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Brain; Brain Ischemia; Cholinesterase Inhibitors; Cognition Disorders; Demography; Donepezil; Double-Blind Method; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Piperidines; Risk Factors; Severity of Illness Index | 2005 |
Switching from donepezil to galantamine: a double-blind study of two wash-out periods.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Galantamine; Humans; Indans; Male; Piperidines | 2005 |
Detecting effects of donepezil on visual selective attention using signal detection parameters in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Attention; Cholinesterase Inhibitors; Cognition; Decision Making; Discrimination, Psychological; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Pattern Recognition, Visual; Photic Stimulation; Piperidines; Signal Detection, Psychological | 2005 |
Practice effects and the use of alternate forms in serial neuropsychological testing.
Topics: Adult; Donepezil; Double-Blind Method; Educational Status; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Practice, Psychological; Reference Values; Reproducibility of Results; Signal Detection, Psychological; Time Factors | 2005 |
A cohort study of effectiveness of acetylcholinesterase inhibitors in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Cohort Studies; Donepezil; Female; Follow-Up Studies; Galantamine; Humans; Indans; Italy; Male; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine; Time Factors; Treatment Outcome | 2005 |
Efficacy and safety of donepezil in patients with more severe Alzheimer's disease: a subgroup analysis from a randomized, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Disability Evaluation; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2005 |
Donepezil for dementia in Parkinson's disease: a randomised, double blind, placebo controlled, crossover study.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cross-Over Studies; Dementia; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Parkinson Disease; Piperidines; Treatment Outcome | 2005 |
Cholinergic enhancement of episodic memory in healthy young adults.
Topics: Adult; Attention; Cholinesterase Inhibitors; Discrimination Learning; Donepezil; Double-Blind Method; Female; Hippocampus; Humans; Indans; Male; Memory, Short-Term; Mental Recall; Neuropsychological Tests; Orientation; Pattern Recognition, Visual; Piperidines; Practice, Psychological; Psychomotor Performance; Reaction Time; Retention, Psychology; Serial Learning; Verbal Learning | 2005 |
Rivastigmine and donepezil treatment in moderate to moderately-severe Alzheimer's disease over a 2-year period.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine; Time Factors; Treatment Outcome | 2005 |
Acetylcholine esterase inhibitor donepezil improves dynamic cerebrovascular regulation in Alzheimer patients.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Blood Flow Velocity; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Echocardiography, Doppler; Female; Humans; Indans; Male; Mental Status Schedule; Piperidines | 2006 |
Treatment persistency with rivastigmine and donepezil in a large state medicaid program.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Patient Compliance; Phenylcarbamates; Piperidines; Research Design; Rivastigmine | 2005 |
Vitamin E and donepezil for the treatment of mild cognitive impairment.
Topics: Aged; Cholinesterase Inhibitors; Cognition Disorders; Confidence Intervals; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Retrospective Studies; Treatment Outcome; Vitamin E | 2005 |
Cholinergic treatment of amnesia following basal forebrain lesion due to aneurysm rupture--an open-label pilot study.
Topics: Adult; Amnesia; Aneurysm, Ruptured; Case-Control Studies; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Memory; Middle Aged; Neuropsychological Tests; Pilot Projects; Piperidines; Prosencephalon; Statistics, Nonparametric; Time Factors; Treatment Outcome | 2005 |
Patient populations in clinical studies of donepezil in vascular dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Dementia, Vascular; Donepezil; Double-Blind Method; Female; Humans; Indans; Ischemic Attack, Transient; Magnetic Resonance Imaging; Male; Middle Aged; Piperidines; Population Surveillance; Psychometrics; Severity of Illness Index; Tomography, X-Ray Computed; Treatment Outcome | 2003 |
Donepezil in vascular dementia: combined analysis of two large-scale clinical trials.
Topics: Activities of Daily Living; Aged; Cholinesterase Inhibitors; Clinical Protocols; Dementia, Vascular; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Humans; Indans; Male; Piperidines | 2005 |
Differential effects of the muscarinic M1 receptor agonist RS-86 and the acetylcholine-esterase inhibitor donepezil on REM sleep regulation in healthy volunteers.
Topics: Adult; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Multivariate Analysis; Piperidines; Reaction Time; Receptor, Muscarinic M1; Sleep, REM; Succinimides | 2006 |
Donepezil effects on mood in patients with schizophrenia and schizoaffective disorder.
Topics: Adult; Affect; Analysis of Variance; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Schizophrenic Psychology | 2006 |
Anticholinesterase effect on motor kinematic measures and brain activation in Parkinson's disease.
Topics: Analysis of Variance; Biomechanical Phenomena; Brain; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Movement; Parkinson Disease; Piperidines; Positron-Emission Tomography | 2006 |
Reality orientation therapy combined with cholinesterase inhibitors in Alzheimer's disease: randomised controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cognition; Combined Modality Therapy; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Quality of Life; Reality Therapy; Treatment Outcome | 2005 |
Neuroanatomical predictors of response to donepezil therapy in patients with dementia.
Topics: Alzheimer Disease; Brain Mapping; Cholinesterase Inhibitors; Donepezil; Hippocampus; Humans; Indans; Longitudinal Studies; Magnetic Resonance Imaging; Piperidines; Time Factors | 2005 |
Manipulating REM sleep in older adults by selective REM sleep deprivation and physiological as well as pharmacological REM sleep augmentation methods.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Piperidines; Polysomnography; Sleep Deprivation; Sleep, REM | 2006 |
Donepezil in the prevention and treatment of post-surgical delirium.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Delirium; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Pilot Projects; Piperidines; Postoperative Complications | 2005 |
Treatment of levodopa-induced dyskinesias with donepezil.
Topics: Aged; Antiparkinson Agents; Donepezil; Dyskinesia, Drug-Induced; Humans; Indans; Levodopa; Male; Middle Aged; Nootropic Agents; Piperidines | 2006 |
A double-blind, placebo-controlled trial of adjunctive donepezil in treatment-resistant mania.
Topics: Adult; Antimanic Agents; Bipolar Disorder; Brief Psychiatric Rating Scale; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Resistance; Drug Therapy, Combination; Female; Humans; Indans; Lithium Compounds; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome; Valproic Acid | 2006 |
The acetylcholinesterase inhibitor, Donepezil, regulates a Th2 bias in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cell Differentiation; Chemokine CCL2; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indans; Interleukin-4; Leukocytes, Mononuclear; Male; Phytohemagglutinins; Piperidines; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Th2 Cells | 2006 |
Beneficial effect of cholinesterase inhibitor medications on recognition memory performance in mild to moderate Alzheimer's disease: preliminary findings.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Memory Disorders; Mental Recall; Mental Status Schedule; Neuropsychological Tests; Phenylcarbamates; Piperidines; Retention, Psychology; Rivastigmine; Verbal Learning | 2006 |
Donepezil for negative signs in elderly patients with schizophrenia: an add-on, double-blind, crossover, placebo-controlled study.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Chronic Disease; Cognition Disorders; Comorbidity; Cross-Over Studies; Dementia; Depressive Disorder; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2006 |
Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child Development Disorders, Pervasive; Cholinesterase Inhibitors; Communication; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Piperidines; Social Behavior | 2006 |
The effect of donepezil on sleep and REM sleep EEG in patients with Alzheimer disease: a double-blind placebo-controlled study.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Electroencephalography; Female; Humans; Indans; Male; Piperidines; Polysomnography; Psychometrics; Sleep, REM | 2006 |
3-year study of donepezil therapy in Alzheimer's disease: effects of early and continuous therapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2006 |
Donepezil and vitamin E for mild cognitive impairment.
Topics: Alzheimer Disease; Cognition Disorders; Donepezil; Humans; Indans; Long-Term Care; Piperidines; Treatment Outcome; Vitamin E | 2006 |
Phase II study of donepezil in irradiated brain tumor patients: effect on cognitive function, mood, and quality of life.
Topics: Adult; Affect; Aged; Anger; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Fatigue; Female; Glioma; Humans; Indans; Male; Memory; Middle Aged; Piperidines; Prospective Studies; Quality of Life; Radiation Injuries | 2006 |
Effect of age on response to rivastigmine or donepezil in patients with Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Severity of Illness Index; Treatment Outcome | 2006 |
Donepezil in patients with severe Alzheimer's disease: double-blind, parallel-group, placebo-controlled study.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Humans; Indans; Middle Aged; Nursing Homes; Piperidines; Severity of Illness Index | 2006 |
Efficacy and safety of donepezil in patients with dementia with Lewy bodies: preliminary findings from an open-label study.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Feasibility Studies; Female; Humans; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2006 |
Assessing therapeutic efficacy in a progressive disease: a study of donepezil in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cognition; Disease Progression; Donepezil; Double-Blind Method; Drug Evaluation; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Single-Blind Method; Time Factors; Treatment Outcome | 2006 |
Donepezil effects on sources of cortical rhythms in mild Alzheimer's disease: Responders vs. Non-Responders.
Topics: Aged; Alzheimer Disease; Brain Mapping; Cerebral Cortex; Data Interpretation, Statistical; Donepezil; Electroencephalography; Female; Humans; Indans; Magnetoencephalography; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales | 2006 |
P300 auditory event-related potentials and neuropsychological study during donepezil treatment in vascular dementia.
Topics: Acoustic Stimulation; Aged; Dementia, Vascular; Donepezil; Electroencephalography; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2006 |
Effects of donepezil on memory and cognition in multiple sclerosis.
Topics: Adult; Analysis of Variance; Cognition; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Male; Memory; Middle Aged; Multiple Sclerosis; Neuropsychological Tests; Nootropic Agents; Piperidines; Retrospective Studies; Task Performance and Analysis; Time Factors | 2006 |
A responder analysis of memantine treatment in patients with Alzheimer disease maintained on donepezil.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Double-Blind Method; Drug Therapy, Combination; Female; Geriatric Assessment; Humans; Indans; Male; Memantine; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2006 |
Verbal repetition in patients with Alzheimer's disease who receive donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Memory, Short-Term; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome; Verbal Behavior | 2006 |
Group therapy for memory impaired patients: a partial remediation is possible.
Topics: Aged; Analysis of Variance; Attention; Donepezil; Female; Humans; Indans; Intelligence Tests; Male; Memory Disorders; Mental Recall; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychomotor Performance; Psychotherapy, Group; Stroke; Stroke Rehabilitation; Verbal Learning | 2006 |
Cardiovascular effects and risk of syncope related to donepezil in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Pressure; Cardiovascular System; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Heart Rate; Humans; Indans; Male; Piperidines; Prospective Studies; Risk; Syncope | 2006 |
Benefits of combining donepezil plus traditional Japanese herbal medicine on cognition and brain perfusion in Alzheimer's disease: a 12-week observer-blind, donepezil monotherapy controlled trial.
Topics: Aged; Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Piperidines; Single-Blind Method | 2006 |
Donepezil effects on cerebral blood flow in older adults with mild cognitive deficits.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Blood Flow Velocity; Brain; Cerebral Cortex; Cognition Disorders; Dominance, Cerebral; Donepezil; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Positron-Emission Tomography; Regional Blood Flow | 2006 |
Brain perfusion effects of cholinesterase inhibitors in Parkinson's disease with dementia.
Topics: Aged; Antiparkinson Agents; Brain; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Image Processing, Computer-Assisted; Indans; Male; Neuropsychological Tests; Parkinson Disease; Phenylcarbamates; Piperidines; Rivastigmine; Tomography, Emission-Computed, Single-Photon | 2006 |
Effects of donepezil on cortical metabolic response to activation during (18)FDG-PET in Alzheimer's disease: a double-blind cross-over trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Fluorodeoxyglucose F18; Humans; Indans; Learning; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Piperidines; Positron-Emission Tomography | 2006 |
[Clinical efficacy and safety of akatinol memantine in treatment of mild to moderate Alzheimer disease: a donepezil-controlled, randomized trial].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Female; Follow-Up Studies; Humans; Indans; Male; Memantine; Middle Aged; Piperidines | 2006 |
Acetylcholinesterase inhibitor donepezil in the treatment of cognitive deficit in schizophrenia. Subanalysis of the active branch from Czech extended double blind study.
Topics: Adolescent; Adult; Cholinesterase Inhibitors; Cognition Disorders; Czech Republic; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory; Middle Aged; Neuropsychological Tests; Piperidines; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2006 |
Effects of donepezil on neuropsychiatric symptoms in patients with dementia and severe behavioral disorders.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Demography; Donepezil; Double-Blind Method; Factor Analysis, Statistical; Female; Humans; Indans; Male; Mental Disorders; Middle Aged; Piperidines; Prevalence; Sertraline; Severity of Illness Index; Treatment Outcome | 2006 |
Behavioral effects of memantine in Alzheimer disease patients receiving donepezil treatment.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Antiparkinson Agents; Behavioral Symptoms; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memantine; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Nootropic Agents; Outcome Assessment, Health Care; Piperidines; Prospective Studies; Psychomotor Agitation; Severity of Illness Index; Time Factors | 2006 |
Cholinesterase inhibitors in advanced Dementia with Lewy bodies: increase or stop?
Topics: Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Lewy Body Disease; Parkinson Disease; Piperidines; Treatment Outcome | 2006 |
Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cognition; Donepezil; Dose-Response Relationship, Drug; Erythrocytes; Female; Humans; Indans; Male; Piperidines; Time Factors | 2006 |
Acetylcholinesterase inhibitors and sleep architecture in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Polysomnography; Rivastigmine; Sleep Stages; Sleep Wake Disorders | 2006 |
Reduced short latency afferent inhibition in diffuse axonal injury patients with memory impairment.
Topics: Adult; Afferent Pathways; Differential Threshold; Diffuse Axonal Injury; Donepezil; Female; Humans; Indans; Male; Memory Disorders; Motor Cortex; Neural Inhibition; Nootropic Agents; Piperidines; Reaction Time; Transcranial Magnetic Stimulation | 2006 |
Regional cerebral blood flow in Alzheimer's disease: comparison between short and long-term donepezil therapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Circulation; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Radionuclide Imaging; Treatment Outcome | 2006 |
Donepezil in patients with severe Alzheimer's disease: double-blind parallel-group, placebo controlled study.
Topics: Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Confidence Intervals; Donepezil; Double-Blind Method; Humans; Indans; Mental Status Schedule; Neuropsychological Tests; Piperidines; Treatment Outcome | 2006 |
Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinesterase Inhibitors; Dementia; Donepezil; Double-Blind Method; Female; Ginkgo biloba; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Piperidines; Plant Extracts | 2006 |
Therapeutic and prophylactic utility of the memory-enhancing drug donepezil hydrochloride on cognition of patients undergoing electroconvulsive therapy: a randomized controlled trial.
Topics: Adult; Cognition; Donepezil; Electroconvulsive Therapy; Humans; Indans; Male; Memory; Memory Disorders; Nootropic Agents; Piperidines; Recovery of Function; Treatment Outcome | 2006 |
Specific symptomatic changes following donepezil treatment of Alzheimer's disease: a multi-centre, primary care, open-label study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Attention; Caregivers; Cost of Illness; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Mental Recall; Mental Status Schedule; Motivation; Nootropic Agents; Orientation; Piperidines; Primary Health Care; Stereotyped Behavior; Treatment Outcome | 2007 |
A randomized, double-blind, placebo-controlled trial of donepezil hydrochloride (Aricept) for reducing the incidence of postoperative delirium after elective total hip replacement.
Topics: Aged; Aged, 80 and over; Arthroplasty, Replacement, Hip; Delirium; Donepezil; Double-Blind Method; Elective Surgical Procedures; England; Female; Hospitals, Teaching; Humans; Incidence; Indans; Length of Stay; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Odds Ratio; Piperidines; Postoperative Complications; Treatment Outcome | 2007 |
Sensory gating deficit assessed by P50/Pb middle latency event related potential in Alzheimer's disease.
Topics: Acoustic Stimulation; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cerebral Cortex; Chi-Square Distribution; Cholinesterase Inhibitors; Donepezil; Evoked Potentials; Female; Gait Disorders, Neurologic; Humans; Indans; Male; Piperidines; Reaction Time; Statistics, Nonparametric; Time Factors | 2006 |
Effect of donepezil on motor and cognitive function in Huntington disease.
Topics: Chorea; Cognition Disorders; Donepezil; Female; Humans; Huntington Disease; Indans; Male; Middle Aged; Nootropic Agents; Outcome Assessment, Health Care; Piperidines; Placebo Effect; Quality of Life; Recovery of Function; Treatment Outcome | 2006 |
Effect of butyrylcholinesterase genotype on the response to rivastigmine or donepezil in younger patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Female; Genetic Variation; Genotype; Heterozygote; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Treatment Outcome | 2006 |
Safety and efficacy of donepezil in African Americans with mild-to-moderate Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Black or African American; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Piperidines; Severity of Illness Index; Treatment Outcome | 2006 |
A 12-week, double-blind, placebo-controlled trial of donepezil as an adjunct to haloperidol for treating cognitive impairments in patients with chronic schizophrenia.
Topics: Adult; Antipsychotic Agents; Cholinesterase Inhibitors; Chronic Disease; Cognition Disorders; Donepezil; Double-Blind Method; Drug Therapy, Combination; Haloperidol; Humans; Indans; Piperidines; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2007 |
A randomized, placebo-controlled study of donepezil in poststroke aphasia.
Topics: Acetylcholine; Adult; Aphasia; Brain; Cerebrovascular Circulation; Donepezil; Double-Blind Method; Female; Humans; Indans; Language Tests; Male; Middle Aged; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Nootropic Agents; Piperidines; Placebos; Recovery of Function; Speech Therapy; Stroke; Treatment Outcome | 2006 |
Efficacy of cognitive rehabilitation in patients with mild cognitive impairment treated with cholinesterase inhibitors.
Topics: Activities of Daily Living; Aged; Cholinesterase Inhibitors; Cognition Disorders; Combined Modality Therapy; Computer-Assisted Instruction; Donepezil; Female; Galantamine; Humans; Indans; Intelligence; Longitudinal Studies; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Orientation; Phenylcarbamates; Piperidines; Problem Solving; Retrospective Studies; Rivastigmine; Software; Treatment Outcome | 2007 |
The effect of donepezil on sleep in elderly, healthy persons: a double-blind placebo-controlled study.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Nootropic Agents; Parasympathetic Nervous System; Piperidines; Polysomnography; Sleep Stages; Sleep, REM; Surveys and Questionnaires | 2006 |
The relationship between REM sleep and memory consolidation in old age and effects of cholinergic medication.
Topics: Aged; Aged, 80 and over; Aging; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory; Middle Aged; Piperidines; Psychomotor Performance; Sleep Deprivation; Sleep, REM | 2007 |
Effects of donepezil on central processing speed and attentional measures in Parkinson's disease with dementia and dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Attention; Chi-Square Distribution; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Female; Humans; Indans; Lewy Body Disease; Male; Mental Processes; Middle Aged; Nootropic Agents; Parkinson Disease; Piperidines; Reaction Time; Reference Values; Statistics, Nonparametric; Treatment Outcome | 2007 |
Preliminary findings: behavioral worsening on donepezil in patients with frontotemporal dementia.
Topics: Behavioral Symptoms; Cholinesterase Inhibitors; Compulsive Behavior; Dementia; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines | 2007 |
Efficacy and safety of donepezil over 3 years: an open-label, multicentre study in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Indans; Long-Term Care; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Single-Blind Method; Treatment Outcome | 2007 |
Qualitative estimates of medial temporal atrophy as a predictor of progression from mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Atrophy; Cognition Disorders; Dementia; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Kaplan-Meier Estimate; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Predictive Value of Tests; Reproducibility of Results; Temporal Lobe; Vitamin E | 2007 |
Clinical predictors of progression to Alzheimer disease in amnestic mild cognitive impairment.
Topics: Age Distribution; Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Antioxidants; Apolipoprotein E4; Cholinesterase Inhibitors; Cognition Disorders; Cohort Studies; Disease Progression; Donepezil; Female; Genotype; Humans; Indans; Linear Models; Male; Neuropsychological Tests; Piperidines; Placebo Effect; Predictive Value of Tests; Prognosis; Sex Distribution; Vitamin E | 2007 |
Donepezil in Alzheimer's disease: what to expect after 3 years of treatment in a routine clinical setting.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Disease Progression; Donepezil; Female; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Statistics, Nonparametric; Sweden; Treatment Outcome | 2007 |
[Clinical study of Reinhartdt and sea cucumber capsule combined with donepezil in treating Alzheimer's disease].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Animals; Capsules; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Medicine, Chinese Traditional; Middle Aged; Nootropic Agents; Piperidines; Radioimmunoassay; Sea Cucumbers; Thyroid Hormones | 2007 |
Double-blind donepezil-placebo crossover augmentation study of atypical antipsychotics in chronic, stable schizophrenia: a pilot study.
Topics: Adult; Antipsychotic Agents; Benzodiazepines; Cholinesterase Inhibitors; Clozapine; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Olanzapine; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Risperidone; Schizophrenia; Schizophrenic Psychology; Treatment Outcome | 2007 |
The DONPAD-study--treatment of dementia in patients with Parkinson's disease with donepezil.
Topics: Aged; Analysis of Variance; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Parkinson Disease; Piperidines; Time Factors | 2006 |
Longitudinal MRI findings from the vitamin E and donepezil treatment study for MCI.
Topics: Aged; Aged, 80 and over; Antioxidants; Atrophy; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Hippocampus; Humans; Incidence; Indans; Longitudinal Studies; Male; Middle Aged; Piperidines; Treatment Outcome; United States; Vitamin E | 2008 |
Quetiapine for agitation or psychosis in patients with dementia and parkinsonism.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Antiparkinson Agents; Antipsychotic Agents; Cholinesterase Inhibitors; Confounding Factors, Epidemiologic; Dementia; Dibenzothiazepines; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Parkinson Disease; Patient Selection; Piperidines; Placebo Effect; Psychomotor Agitation; Psychotic Disorders; Quetiapine Fumarate; Research Design; Severity of Illness Index; Treatment Failure | 2007 |
A randomized, double-blind, placebo-controlled trial of donepezil to improve memory in epilepsy.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Cross-Over Studies; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Epilepsy; Health Status; Humans; Indans; Memory Disorders; Neuropsychological Tests; Piperidines; Placebos; Quality of Life; Severity of Illness Index; Social Adjustment; Treatment Outcome | 2007 |
Cognitive predictors of donepezil therapy response in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Predictive Value of Tests; Prospective Studies; Severity of Illness Index | 2007 |
Donepezil for cognitive decline following coronary artery bypass surgery: a pilot randomized controlled trial.
Topics: Aged; Cardiopulmonary Bypass; Cognition Disorders; Coronary Artery Bypass; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Electrocardiography; Female; Follow-Up Studies; Humans; Indans; Male; Memory, Short-Term; Mental Recall; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Postoperative Complications; Wechsler Scales | 2007 |
Preliminary study of the safety and efficacy of donepezil hydrochloride in children with Down syndrome: a clinical report series.
Topics: Adolescent; Child; Cholinesterase Inhibitors; Cognition; Donepezil; Down Syndrome; Drug Administration Schedule; Female; Humans; Indans; Male; Piperidines; Treatment Outcome | 2007 |
Omega-3 supplementation in mild to moderate Alzheimer's disease: effects on neuropsychiatric symptoms.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Analysis of Variance; Apolipoproteins E; Cholinesterase Inhibitors; Depression; Dietary Supplements; Donepezil; Double-Blind Method; Fatty Acids, Omega-3; Female; Galantamine; Genotype; Humans; Indans; Male; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Rivastigmine; Statistics, Nonparametric; Treatment Outcome | 2008 |
Key lessons learned from short-term treatment trials of cholinesterase inhibitors for amnestic MCI.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Cohort Studies; Donepezil; History, 20th Century; Humans; Indans; Memory Disorders; Neuropsychological Tests; Outcome Assessment, Health Care; Piperidines; Placebos; Psychiatric Status Rating Scales; Psychomotor Performance; Randomized Controlled Trials as Topic; Research Design; Severity of Illness Index; Treatment Outcome; United States | 2008 |
A randomised double-blind placebo-controlled trial of folic acid supplementation of cholinesterase inhibitors in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Chi-Square Distribution; Cholinesterase Inhibitors; Dietary Supplements; Donepezil; Double-Blind Method; Female; Folic Acid; Folic Acid Deficiency; Galantamine; Homocysteine; Humans; Indans; Male; Mental Status Schedule; Phenylcarbamates; Piperidines; Placebos; Rivastigmine; Treatment Outcome; Vitamin B Complex; Vitamins | 2008 |
Efficacy and safety of donepezil in patients with schizophrenia or schizoaffective disorder: significant placebo/practice effects in a 12-week, randomized, double-blind, placebo-controlled trial.
Topics: Adult; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Placebo Effect; Practice, Psychological; Prospective Studies; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia; Time Factors | 2008 |
Does the cholinesterase inhibitor, donepezil, benefit both declarative and non-declarative processes in mild to moderate Alzheimer's disease?
Topics: Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Learning; Male; Neuropsychological Tests; Pilot Projects; Piperidines; Psychomotor Performance; Reaction Time | 2007 |
Donepezil preserves cognition and global function in patients with severe Alzheimer disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Placebos; Recovery of Function; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2007 |
Donepezil for cancer fatigue: a double-blind, randomized, placebo-controlled trial.
Topics: Aged; Disease Progression; Donepezil; Double-Blind Method; Fatigue; Female; Humans; Indans; Male; Middle Aged; Neoplasms; Nootropic Agents; Piperidines; Placebos; Telemedicine; Time Factors; Treatment Outcome | 2007 |
No effect of donepezil on neurocognition and social cognition in young persons with stable schizophrenia.
Topics: Adult; Brain; Brief Psychiatric Rating Scale; Cholinesterase Inhibitors; Cognition Disorders; Diagnostic and Statistical Manual of Mental Disorders; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Schizophrenia; Severity of Illness Index; Social Perception | 2007 |
Donepezil for the treatment of agitation in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Psychomotor Agitation; Psychotherapy; Social Support; Treatment Failure | 2007 |
Alpha-lipoic acid as a new treatment option for Alzheimer's disease--a 48 months follow-up analysis.
Topics: Aged; Alzheimer Disease; Antioxidants; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Female; Follow-Up Studies; Galantamine; Humans; Indans; Long-Term Care; Male; Mental Status Schedule; Middle Aged; Oxidative Stress; Piperidines; Thioctic Acid | 2007 |
Effectiveness of open-label donepezil treatment in patients with Alzheimer's disease discontinuing memantine monotherapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antiparkinson Agents; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Memantine; Middle Aged; Piperidines; Treatment Outcome | 2007 |
Increase of BDNF serum concentration during donepezil treatment of patients with early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain-Derived Neurotrophic Factor; Case-Control Studies; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Matched-Pair Analysis; Middle Aged; Piperidines; Up-Regulation | 2008 |
[Clinical study of combined treatment with compound Reinhartdt and Sea Cumber Capsule and donepezil for vascular dementia].
Topics: Aged; Aged, 80 and over; Capsules; Dementia, Vascular; Donepezil; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Materia Medica; Medicine, Chinese Traditional; Middle Aged; Nootropic Agents; Piperidines; Treatment Outcome | 2007 |
Efficacy of multivitamin supplementation containing vitamins B6 and B12 and folic acid as adjunctive treatment with a cholinesterase inhibitor in Alzheimer's disease: a 26-week, randomized, double-blind, placebo-controlled study in Taiwanese patients.
Topics: Aged; Alzheimer Disease; Asian People; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Folic Acid; Homocysteine; Humans; Indans; Male; Piperidines; Taiwan; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2007 |
Randomized double-blind placebo-controlled donepezil augmentation in antidepressant-treated elderly patients with depression and cognitive impairment: a pilot study.
Topics: Aged; Antidepressive Agents; Cholinesterase Inhibitors; Cognition Disorders; Depressive Disorder; Donepezil; Epidemiologic Methods; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Sertraline; Treatment Outcome | 2008 |
A 12-week open-label pilot study of donepezil for cognitive functioning and instrumental activities of daily living in late-life bipolar disorder.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Bipolar Disorder; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Piperidines; Prospective Studies; Psychiatric Status Rating Scales | 2008 |
Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebo-controlled study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Polysomnography; Psychometrics; Sleep Apnea, Obstructive; Sleep, REM; Treatment Outcome | 2008 |
A double-blind, placebo-controlled trial of donepezil for the treatment of menopause-related cognitive loss.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Memory Disorders; Menopause; Middle Aged; Piperidines; Treatment Outcome | 2007 |
Tolerability of switching from donepezil to memantine treatment in patients with moderate to severe Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Double-Blind Method; Female; Humans; Indans; Male; Memantine; Piperidines; Severity of Illness Index | 2008 |
Treatment of a whole population sample of Alzheimer's disease with donepezil over a 4-year period: lessons learned.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Cohort Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Severity of Illness Index | 2008 |
High field (1)H MRS of the hippocampus after donepezil treatment in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain Chemistry; Choline; Cholinesterase Inhibitors; Creatine; Donepezil; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Piperidines; Protons | 2008 |
Safety and tolerability of donepezil at doses up to 20 mg/day: results from a pilot study in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Electrocardiography; Female; Humans; Indans; Male; Middle Aged; Pilot Projects; Piperidines; Psychiatric Status Rating Scales; Psychometrics; Severity of Illness Index; Treatment Outcome | 2008 |
Donepezil in patients with subcortical vascular cognitive impairment: a randomised double-blind trial in CADASIL.
Topics: Adult; Aged; CADASIL; Cognition Disorders; Confidence Intervals; Donepezil; Double-Blind Method; Female; Humans; Indans; International Cooperation; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Problem Solving | 2008 |
Donepezil use in children and adolescents with tics and attention-deficit/hyperactivity disorder: an 18-week, single-center, dose-escalating, prospective, open-label study.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Cholinesterase Inhibitors; Comorbidity; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Pilot Projects; Piperidines; Prospective Studies; Severity of Illness Index; Tic Disorders | 2008 |
Donepezil treatment of patients with severe Alzheimer's disease in a Japanese population: results from a 24-week, double-blind, placebo-controlled, randomized trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Japan; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2008 |
Effect of ApoE genotype on response to donepezil in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Donepezil; Drug Resistance; Female; Follow-Up Studies; Genotype; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Treatment Outcome | 2008 |
Prediction of response to donepezil in Alzheimer's disease: combined MRI analysis of the substantia innominata and SPECT measurement of cerebral perfusion.
Topics: Aged; Alzheimer Disease; Brain; Cerebrovascular Circulation; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Outcome Assessment, Health Care; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Substantia Innominata; Subtraction Technique; Tomography, Emission-Computed, Single-Photon | 2008 |
Quantitative analysis of the effects of donepezil on regional cerebral blood flow in Alzheimer's disease by using an automated program, 3DSRT.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Indans; Male; Piperidines; Tomography, Emission-Computed, Single-Photon | 2008 |
Specific impairments in visuospatial working and short-term memory following low-dose scopolamine challenge in healthy older adults.
Topics: Aged; Aged, 80 and over; Analysis of Variance; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Geriatric Assessment; Humans; Indans; Linear Models; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Piperidines; Scopolamine; Spatial Behavior | 2008 |
Comprehensive approach of donepezil and psychosocial interventions on cognitive function and quality of life for Alzheimer's disease: the Osaki-Tajiri Project.
Topics: Aged; Alzheimer Disease; Art; Cognition Disorders; Combined Modality Therapy; Donepezil; Humans; Indans; Nootropic Agents; Nursing Homes; Occupational Therapy; Piperidines; Quality of Life; Social Support; Treatment Outcome | 2008 |
Effects of donepezil on verbal memory after semantic processing in healthy older adults.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Attention; Cholinesterase Inhibitors; Comprehension; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Memory, Short-Term; Mental Recall; Neuropsychological Tests; Nootropic Agents; Pattern Recognition, Visual; Piperidines; Retention, Psychology; Semantics; Serial Learning; Verbal Learning | 2008 |
The use of truncated area under the curves in the bioequivalence evaluation of long half-life drugs. Studies with donepezil and memantine.
Topics: Adolescent; Adult; Algorithms; Area Under Curve; Cross-Over Studies; Donepezil; Excitatory Amino Acid Antagonists; Female; Half-Life; Humans; Indans; Linear Models; Male; Memantine; Middle Aged; Models, Statistical; Nootropic Agents; Piperidines; Tablets, Enteric-Coated; Therapeutic Equivalency | 2008 |
The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Anticholesteremic Agents; Atorvastatin; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Female; Heptanoic Acids; Humans; Indans; Lipids; Male; Middle Aged; Piperidines; Pyrroles | 2008 |
An open-label pilot study of acetylcholinesterase inhibitors to promote functional recovery in elderly cognitively impaired stroke patients.
Topics: Aged; Attention; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Feasibility Studies; Female; Galantamine; Humans; Indans; Male; Middle Aged; Motivation; Motor Activity; Nootropic Agents; Pilot Projects; Piperidines; Prospective Studies; Recovery of Function; Stroke; Treatment Outcome | 2008 |
A 12-week, double-blind, placebo-controlled trial of donepezil adjunctive treatment to risperidone in chronic and stable schizophrenia.
Topics: Adult; Antipsychotic Agents; Chronic Disease; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Neuropsychological Tests; Nootropic Agents; Piperidines; Prospective Studies; Risperidone; Schizophrenia; Treatment Outcome; Young Adult | 2008 |
Predicting long-term cognitive outcome with new regression models in donepezil-treated Alzheimer patients in a naturalistic setting.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Donepezil; Female; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Models, Statistical; Nootropic Agents; Patient Dropouts; Piperidines; Predictive Value of Tests; Psychiatric Status Rating Scales; Regression Analysis; Severity of Illness Index | 2008 |
Acetylcholinesterase inhibitor in combination with cognitive training in older adults.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Combined Modality Therapy; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory Disorders; Middle Aged; Piperidines; Psychotherapy | 2008 |
A rapid and specific approach for direct measurement of donepezil concentration in human plasma by LC-MS/MS employing solid-phase extraction.
Topics: Adult; Anticoagulants; Cholinesterase Inhibitors; Chromatography, Liquid; Citalopram; Donepezil; Drug Stability; Humans; Indans; Linear Models; Male; Piperidines; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2009 |
Periventricular white matter hyperintensities increase the likelihood of progression from amnestic mild cognitive impairment to dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Antioxidants; Atrophy; Brain; Cerebral Ventricles; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Piperidines; Prospective Studies; Temporal Lobe; Time Factors; Treatment Outcome; Vitamin E | 2008 |
A three-country randomized controlled trial of a psychosocial intervention for caregivers combined with pharmacological treatment for patients with Alzheimer disease: effects on caregiver depression.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Australia; Caregivers; Cholinesterase Inhibitors; Counseling; Depression; Donepezil; Family Therapy; Female; Humans; Indans; Linear Models; Longitudinal Studies; Male; Middle Aged; Piperidines; Social Support; Spouses; Surveys and Questionnaires; United Kingdom; United States | 2008 |
Effects of donepezil on cortical activation in mild cognitive impairment: a pilot double-blind placebo-controlled trial using functional MR imaging.
Topics: Aged; Cerebral Cortex; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Nootropic Agents; Pilot Projects; Piperidines; Placebos; Severity of Illness Index | 2009 |
Cholinergic enhancement reduces spatial spread of visual responses in human early visual cortex.
Topics: Acetylcholine; Brain Mapping; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Eye Movements; Female; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Oxygen; Photic Stimulation; Piperidines; Psychophysics; Time Factors; Visual Cortex; Visual Pathways | 2008 |
Effect of donepezil on tardive dyskinesia.
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Dyskinesia, Drug-Induced; Female; Humans; Indans; Male; Middle Aged; Piperidines | 2009 |
The effects of donepezil on postlearning sleep EEG of healthy older adults.
Topics: Administration, Oral; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Electroencephalography; Female; Geriatric Assessment; Humans; Indans; Male; Middle Aged; Piperidines; Sleep; Sleep Stages; Spectrum Analysis | 2009 |
Donepezil treatment of patients with MCI: a 48-week randomized, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Double-Blind Method; Endpoint Determination; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Outcome Assessment, Health Care; Patient Compliance; Piperidines; Severity of Illness Index; Treatment Outcome | 2009 |
Serum albumin level interferes with the effect of donepezil in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Monitoring; Female; Humans; Indans; Male; Piperidines; Serum Albumin; Treatment Outcome | 2008 |
Different cholinesterase inhibitor effects on CSF cholinesterases in Alzheimer patients.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Down-Regulation; Enzyme-Linked Immunosorbent Assay; Female; Galantamine; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2009 |
Changes in cognitive domains during three years in patients with Alzheimer's disease treated with donepezil.
Topics: Aged; Algorithms; Alzheimer Disease; Analysis of Variance; Apolipoproteins E; Cognition; Donepezil; Factor Analysis, Statistical; Female; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Time Factors; Treatment Outcome | 2009 |
Cholinergic dysfunction in fragile X syndrome and potential intervention: a preliminary 1H MRS study.
Topics: Adolescent; Adult; Case-Control Studies; Choline; Cholinesterase Inhibitors; Cognition; Creatine; Donepezil; Dose-Response Relationship, Drug; Female; Fragile X Mental Retardation Protein; Fragile X Syndrome; Humans; Indans; Intelligence; Male; Nuclear Magnetic Resonance, Biomolecular; Pilot Projects; Piperidines; Prefrontal Cortex; Prospective Studies; Radiography; Time Factors; Treatment Outcome; Young Adult | 2009 |
Errorless practice as a possible adjuvant to donepezil in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Behavior Therapy; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Treatment Outcome | 2009 |
Long-term safety and efficacy of donepezil in patients with severe Alzheimer's disease: results from a 52-week, open-label, multicenter, extension study in Japan.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Nootropic Agents; Piperidines | 2009 |
Methodological improvements in quantifying cognitive change in clinical trials: an example with single-dose administration of donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Humans; Indans; Male; Maze Learning; Memory, Short-Term; Middle Aged; Neuropsychological Tests; Piperidines; Psychometrics; Reproducibility of Results; Research Design; Sensitivity and Specificity | 2009 |
A combination therapy of donepezil and cilostazol for patients with moderate Alzheimer disease: pilot follow-up study.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cilostazol; Donepezil; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Phosphodiesterase Inhibitors; Pilot Projects; Piperidines; Tetrazoles | 2009 |
Ginkgo biloba extract EGb 761(R), donepezil or both combined in the treatment of Alzheimer's disease with neuropsychiatric features: a randomised, double-blind, exploratory trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bulgaria; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Ginkgo biloba; Humans; Indans; Male; Middle Aged; Nootropic Agents; Outcome Assessment, Health Care; Piperidines; Plant Extracts | 2009 |
Selective benefit of donepezil on oral naming in Alzheimer's disease in men compared to women.
Topics: Alzheimer Disease; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Psychomotor Performance; Sex Characteristics | 2009 |
Effect of donepezil added to atypical antipsychotics on cognition in patients with schizophrenia: an open-label trial.
Topics: Adult; Antipsychotic Agents; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology | 2009 |
Donepezil delays progression to AD in MCI subjects with depressive symptoms.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Brain; Cholinesterase Inhibitors; Cognition Disorders; Depressive Disorder; Disease Progression; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Placebos; Severity of Illness Index; Time Factors; Tocopherols; Treatment Outcome | 2009 |
[Clinical observation on acupuncture combined with Yizhi Jiannao granules for treatment of Alzheimer's disease].
Topics: Acupuncture Points; Acupuncture Therapy; Administration, Oral; Aged; Alpinia; Alzheimer Disease; Combined Modality Therapy; Donepezil; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Plant Extracts; Quality of Life; Treatment Outcome | 2009 |
High occupancy of sigma1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503.
Topics: Administration, Oral; Adult; Brain; Brain Mapping; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Middle Aged; Piperazines; Piperidines; Positron-Emission Tomography; Radioligand Assay; Receptors, sigma; Young Adult | 2009 |
Smell identification test as a treatment response marker in patients with Alzheimer disease receiving donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Monitoring; Female; Humans; Indans; Male; Odorants; Olfaction Disorders; Piperidines; Predictive Value of Tests; Severity of Illness Index; Smell; Treatment Outcome | 2009 |
Clinical effects of high oral dose of donepezil for patients with Alzheimer's disease in Japan.
Topics: Aged; Alzheimer Disease; Apolipoprotein E4; Cholinesterase Inhibitors; Cognition; Disease Progression; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Genetic Predisposition to Disease; Humans; Indans; Japan; Male; Nootropic Agents; Piperidines | 2009 |
The efficacy, safety, and tolerability of donepezil for the treatment of young adults with Down syndrome.
Topics: Adult; Demography; Donepezil; Double-Blind Method; Down Syndrome; Female; Humans; Indans; Learning; Male; Nootropic Agents; Piperidines; Treatment Outcome; Young Adult | 2009 |
The long-term efficacy and tolerability of donepezil in patients with vascular dementia.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales | 2010 |
DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT.
Topics: Alzheimer Disease; Donepezil; Dopamine Agents; Evidence-Based Medicine; Humans; Indans; Memantine; Nootropic Agents; Piperidines; Research Design; Severity of Illness Index | 2009 |
Acute cognitive effects of donepezil in young, healthy volunteers.
Topics: Adult; Affect; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Humans; Indans; Male; Memory; Nootropic Agents; Piperidines; Time Factors; Young Adult | 2009 |
Can cognitive enhancers reduce the risk of falls in older people with mild cognitive impairment? A protocol for a randomised controlled double blind trial.
Topics: Accidental Falls; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Clinical Protocols; Cognition Disorders; Community-Based Participatory Research; Donepezil; Double-Blind Method; Female; Gait; Humans; Indans; Male; Patient Selection; Piperidines; Treatment Outcome | 2009 |
Brief psychosocial therapy for the treatment of agitation in Alzheimer disease (the CALM-AD trial).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Homes for the Aged; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nursing Homes; Piperidines; Psychomotor Agitation; Psychotherapy; Treatment Outcome | 2009 |
The effects of counseling spouse caregivers of people with Alzheimer disease taking donepezil and of country of residence on rates of admission to nursing homes and mortality.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Australia; Caregivers; Cholinesterase Inhibitors; Counseling; Donepezil; Female; Homes for the Aged; Humans; Indans; Institutionalization; Male; Nursing Homes; Piperidines; Social Support; Spouses; Surveys and Questionnaires; United Kingdom; United States | 2009 |
Donepezil improves episodic memory in young individuals vulnerable to the effects of sleep deprivation.
Topics: Administration, Oral; Adult; Arousal; Brain; Brain Mapping; Cholinesterase Inhibitors; Cross-Over Studies; Dominance, Cerebral; Donepezil; Double-Blind Method; Drug Administration Schedule; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Mental Recall; Nootropic Agents; Piperidines; Premedication; Recognition, Psychology; Sleep Deprivation; Verbal Learning; Young Adult | 2009 |
Effectiveness of donepezil in reducing clinical worsening in patients with mild-to-moderate alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Odds Ratio; Piperidines; Treatment Outcome | 2009 |
Donepezil treatment and the subjective effects of intravenous cocaine in dependent individuals.
Topics: Behavior, Addictive; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Humans; Indans; Infusions, Intravenous; Male; Middle Aged; Piperidines; Reinforcement, Psychology | 2010 |
A 22-week, multicenter, randomized, double-blind controlled trial of Crocus sativus in the treatment of mild-to-moderate Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Crocus; Donepezil; Double-Blind Method; Female; Humans; Indans; Iran; Male; Piperidines; Plant Extracts; Psychiatric Status Rating Scales; Severity of Illness Index | 2010 |
Memantine versus donepezil in mild to moderate Alzheimer's disease: a randomized trial with magnetic resonance spectroscopy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aspartic Acid; Brain; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Protons; Severity of Illness Index; Treatment Outcome | 2010 |
A 25-week, open-label trial investigating rivastigmine transdermal patches with concomitant memantine in mild-to-moderate Alzheimer's disease: a post hoc analysis.
Topics: Administration, Cutaneous; Aged; Aged, 80 and over; Algorithms; Alzheimer Disease; Antiparkinson Agents; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Drug Therapy, Combination; Female; Humans; Indans; Male; Memantine; Middle Aged; Neuroprotective Agents; Phenylcarbamates; Piperidines; Rivastigmine; Severity of Illness Index; Time Factors; Treatment Outcome | 2010 |
The progression of cognitive deterioration and regional cerebral blood flow patterns in Alzheimer's disease: a longitudinal SPECT study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Cerebral Arteries; Cerebral Cortex; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disability Evaluation; Disease Progression; Donepezil; Female; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Piperidines; Predictive Value of Tests; Prognosis; Sensitivity and Specificity; Severity of Illness Index; Time Factors; Tomography, Emission-Computed, Single-Photon | 2010 |
Safety and tolerability of donepezil in mild cognitive impairment: open-label extension study.
Topics: Adult; Aged; Aged, 80 and over; Amnesia; Cholinesterase Inhibitors; Cognition Disorders; Diarrhea; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Nausea; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Severity of Illness Index; Sleep Initiation and Maintenance Disorders; Spasm; Time Factors; Treatment Outcome | 2010 |
Treatment of behavioral and psychological symptoms of Alzheimer-type dementia with Yokukansan in clinical practice.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Behavioral Symptoms; Donepezil; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Mental Status Schedule; Neuropsychological Tests; Nootropic Agents; Piperidines; Statistics, Nonparametric | 2010 |
Treatment of Alzheimer's disease with a cholinesterase inhibitor combined with antioxidants.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antioxidants; Bisphenol A-Glycidyl Methacrylate; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Homocysteine; Humans; Indans; Male; Models, Biological; Oxidative Stress; Piperidines; Polyurethanes; Proteoglycans; Reactive Oxygen Species; Time Factors; Treatment Outcome | 2010 |
Randomized, placebo-controlled, clinical trial of donepezil in vascular dementia: differential effects by hippocampal size.
Topics: Adult; Aged; Aged, 80 and over; Cognition; Dementia, Vascular; Donepezil; Double-Blind Method; Female; Hippocampus; Humans; Indans; Male; Middle Aged; Nootropic Agents; Organ Size; Piperidines; Radiography | 2010 |
Cognition and function in Alzheimer's disease: identifying the transitions from moderate to severe disease.
Topics: Activities of Daily Living; Alzheimer Disease; Cognition; Disability Evaluation; Donepezil; Double-Blind Method; Humans; Indans; Nootropic Agents; Piperidines; Severity of Illness Index | 2010 |
Bioequivalence study of two different tablet formulations of donepezil using truncated areas under the curve. A single-center, single-dose, randomized, open-label, 2-way crossover study under fasting conditions.
Topics: Adult; Analysis of Variance; Area Under Curve; Calibration; Chemistry, Pharmaceutical; Cross-Over Studies; Data Interpretation, Statistical; Donepezil; Electrocardiography; Fasting; Female; Humans; Indans; Male; Mass Spectrometry; Middle Aged; Nootropic Agents; Piperidines; Tablets; Tandem Mass Spectrometry; Therapeutic Equivalency; Young Adult | 2010 |
An MRI substudy of a donepezil clinical trial in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Brain; Cognitive Dysfunction; Donepezil; Double-Blind Method; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Piperidines; Single-Blind Method | 2011 |
Efficacy and safety of donepezil in patients with Alzheimer's disease in assisted living facilities.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Assisted Living Facilities; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2010 |
Effect of donepezil on emergence of apathy in mild to moderate Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apathy; Brief Psychiatric Rating Scale; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Severity of Illness Index | 2011 |
Effect of donepezil on cognition in severe Alzheimer's disease: a pooled data analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2010 |
Effectiveness and tolerability of high-dose (23 mg/d) versus standard-dose (10 mg/d) donepezil in moderate to severe Alzheimer's disease: A 24-week, randomized, double-blind study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Piperidines; Severity of Illness Index | 2010 |
Cognitive stimulation therapy in the treatment of neuropsychiatric symptoms in Alzheimer's disease: a randomized controlled trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Behavioral Symptoms; China; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Combined Modality Therapy; Donepezil; Executive Function; Female; Humans; Indans; Male; Memory, Short-Term; Piperidines; Single-Blind Method | 2010 |
Rosiglitazone monotherapy in mild-to-moderate Alzheimer's disease: results from a randomized, double-blind, placebo-controlled phase III study.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Cholinesterase Inhibitors; Donepezil; Drug-Related Side Effects and Adverse Reactions; Edema; Female; Genotype; Humans; Hypoglycemic Agents; Indans; Intelligence Tests; Interview, Psychological; Male; Middle Aged; Nasopharyngitis; Piperidines; PPAR gamma; Rosiglitazone; Thiazolidinediones; Treatment Outcome | 2010 |
Effects of a central cholinesterase inhibitor on reducing falls in Parkinson disease.
Topics: Aged; Cholinesterase Inhibitors; Cross-Over Studies; Disability Evaluation; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Parkinson Disease; Piperidines; Postural Balance; Sensation Disorders; Severity of Illness Index; Statistics, Nonparametric | 2010 |
Cholinergic enhancement increases the effects of voluntary attention but does not affect involuntary attention.
Topics: Adult; Attention; Cholinesterase Inhibitors; Cues; Donepezil; Female; Humans; Indans; Male; Piperidines; Psychomotor Performance; Reaction Time; Spatial Behavior | 2010 |
Donepezil treatment in Alzheimer's disease patients with and without cerebrovascular lesions: a preliminary report.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Disorders; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Piperidines; Retrospective Studies; Time Factors; Treatment Outcome | 2011 |
SB-742457 and donepezil in Alzheimer disease: a randomized, placebo-controlled study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Quinolines; Serotonin Antagonists; Sulfones | 2011 |
[The effect of donepezil in comparison with conventional treatment on cognitive functioning and the performance of the patient in a prospective cohort of patients with Alzheimer's disease treated in routine clinical practice in Spain].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Cost of Illness; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Spain | 2010 |
Improved visual hallucination by donepezil and occipital glucose metabolism in dementia with Lewy bodies: the Osaki-Tajiri project.
Topics: Aged, 80 and over; Donepezil; Female; Glucose; Hallucinations; Humans; Image Interpretation, Computer-Assisted; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Nootropic Agents; Occipital Lobe; Piperidines; Positron-Emission Tomography | 2010 |
Donepezil for treatment of cognitive dysfunction in children with Down syndrome aged 10-17.
Topics: Adolescent; Behavior; Caregivers; Child; Cholinesterase Inhibitors; Cognition Disorders; Diarrhea; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Down Syndrome; Drug Tolerance; Female; Humans; Indans; Learning; Male; Neuropsychological Tests; Piperidines; Severity of Illness Index; Vomiting | 2010 |
Short-term effect of combined drug therapy and cognitive stimulation therapy on the cognitive function of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Combined Modality Therapy; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Mathematics; Neuropsychological Tests; Piperidines; Problem Solving; Reading; Verbal Learning | 2010 |
Galantamine (Reminyl) once daily outcome and satisfaction survey (RODOS) in mild to moderate Alzheimer's disease: a study in a real life population.
Topics: Aged; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cognition; Delayed-Action Preparations; Donepezil; Female; Galantamine; Humans; Indans; Male; Patient Satisfaction; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2011 |
Maintenance treatment of depression in old age: a randomized, double-blind, placebo-controlled evaluation of the efficacy and safety of donepezil combined with antidepressant pharmacotherapy.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Aging; Antidepressive Agents; Cholinesterase Inhibitors; Cognition; Depressive Disorder, Major; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Indans; Male; Nootropic Agents; Piperidines; Secondary Prevention; Treatment Outcome | 2011 |
Effects of AZD3480 on cognition in patients with mild-to-moderate Alzheimer's disease: a phase IIb dose-finding study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Neuroprotective Agents; Neuropsychological Tests; Piperidines; Pyridines; Time Factors; Treatment Outcome | 2011 |
Acute effects of donepezil in healthy young adults underline the fractionation of executive functioning.
Topics: Adolescent; Adult; Attention; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Executive Function; Humans; Indans; Male; Memory, Short-Term; Neuropsychological Tests; Piperidines; Psychomotor Performance; Reaction Time; Young Adult | 2011 |
Safety and efficacy of donepezil in children and adolescents with autism: neuropsychological measures.
Topics: Adolescent; Autistic Disorder; Child; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Executive Function; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines | 2011 |
A double-blind placebo-controlled randomized trial of Melissa officinalis oil and donepezil for the treatment of agitation in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Aromatherapy; Cholinesterase Inhibitors; Data Interpretation, Statistical; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Melissa; Middle Aged; Nootropic Agents; Patient Compliance; Piperidines; Plant Oils; Psychomotor Agitation; Quality of Life; Sample Size; Treatment Outcome | 2011 |
Donepezil significantly improves abilities in daily lives of female Down syndrome patients with severe cognitive impairment: a 24-week randomized, double-blind, placebo-controlled trial.
Topics: Activities of Daily Living; Adult; Cognition Disorders; Donepezil; Double-Blind Method; Down Syndrome; Female; Humans; Indans; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Quality of Life; Treatment Outcome | 2011 |
Multicenter randomized clinical trial of donepezil for memory impairment in multiple sclerosis.
Topics: Adolescent; Adult; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Memory Disorders; Middle Aged; Multiple Sclerosis; Neuropsychological Tests; Piperidines; Treatment Outcome; Verbal Learning; Young Adult | 2011 |
Rosiglitazone does not improve cognition or global function when used as adjunctive therapy to AChE inhibitors in mild-to-moderate Alzheimer's disease: two phase 3 studies.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chemotherapy, Adjuvant; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Hypoglycemic Agents; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Rosiglitazone; Thiazolidinediones | 2011 |
Safety and tolerability of donepezil 23 mg in moderate to severe Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Body Weight; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Emergency Services, Psychiatric; Female; Humans; Indans; Male; Piperidines; Severity of Illness Index; Sex Factors; Treatment Outcome | 2011 |
Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans.
Topics: Adult; Area Under Curve; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Donepezil; Double-Blind Method; Drug Inverse Agonism; Drug Therapy, Combination; Histamine Agonists; Humans; Indans; Male; Maze Learning; Piperidines; Receptors, Histamine H3; Scopolamine; Young Adult | 2011 |
Combination treatment in Alzheimer's disease: results of a randomized, controlled trial with cerebrolysin and donepezil.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Amino Acids; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Neuroprotective Agents; Neuropsychological Tests; Piperidines; Treatment Outcome | 2011 |
Evaluation of the regional cerebral blood flow changes during long-term donepezil therapy in patients with Alzheimer's disease using 3DSRT.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Flow Velocity; Cerebrovascular Circulation; Donepezil; Female; Humans; Imaging, Three-Dimensional; Indans; Longitudinal Studies; Male; Middle Aged; Nootropic Agents; Piperidines; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2012 |
Neural correlates of donepezil-induced cognitive improvement in patients with right hemisphere stroke: a pilot study.
Topics: Adult; Aged; Brain Mapping; Cognition Disorders; Donepezil; Female; Functional Laterality; Humans; Indans; Male; Middle Aged; Neural Pathways; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Piperidines; Stroke | 2011 |
Pharmacokinetic comparison of orally disintegrating and conventional donepezil formulations in healthy Korean male subjects: a single-dose, randomized, open-label, 2-sequence, 2-period crossover study.
Topics: Administration, Oral; Adult; Area Under Curve; Asian People; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Humans; Indans; Male; Middle Aged; Piperidines; Republic of Korea; Therapeutic Equivalency; Young Adult | 2011 |
Cognitive impairment and MS: searching for effective therapies.
Topics: Adolescent; Adult; Aged; Cognition Disorders; Disability Evaluation; Donepezil; Double-Blind Method; Executive Function; Female; Humans; Indans; Male; Middle Aged; Multiple Sclerosis; Neuropsychological Tests; Nootropic Agents; Piperidines; Retrospective Studies; Treatment Outcome; Verbal Learning; Young Adult | 2011 |
An open label trial of donepezil for enhancement of rapid eye movement sleep in young children with autism spectrum disorders.
Topics: Autistic Disorder; Child; Child Development Disorders, Pervasive; Child, Preschool; Developmental Disabilities; Donepezil; Dose-Response Relationship, Drug; Electrocardiography; Humans; Indans; Male; Nootropic Agents; Piperidines; Polysomnography; Sleep; Sleep Wake Disorders; Sleep, REM; Treatment Outcome | 2011 |
The effects of donepezil on computer-simulated driving ability among healthy older adults: a pilot study.
Topics: Aged; Aged, 80 and over; Attention; Automobile Driving; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Nootropic Agents; Pilot Projects; Piperidines; Reaction Time; User-Computer Interface | 2011 |
The scopolamine model as a pharmacodynamic marker in early drug development.
Topics: Adult; Animals; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Design; Humans; Indans; Male; Maze Learning; Memory; Middle Aged; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Long-Evans; Scopolamine; Single-Blind Method; Species Specificity; Time Factors; Young Adult | 2012 |
Donepezil impairs memory in healthy older subjects: behavioural, EEG and simultaneous EEG/fMRI biomarkers.
Topics: Aged; Analysis of Variance; Cholinesterase Inhibitors; Cognition; Cross-Over Studies; Diarrhea; Donepezil; Double-Blind Method; Electroencephalography; Female; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Male; Memory; Middle Aged; Nausea; Piperidines; Vomiting | 2011 |
Two galantamine titration regimens in patients switched from donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Galantamine; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Treatment Outcome | 2012 |
Pilot randomized trial of donepezil hydrochloride for delirium after hip fracture.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Delirium; Donepezil; Double-Blind Method; Female; Hip Fractures; Humans; Indans; Male; Pilot Projects; Piperidines; Postoperative Complications; Prospective Studies | 2011 |
Effects of donepezil on cognitive performance after sleep deprivation.
Topics: Adult; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Psychomotor Performance; Reaction Time; Sleep Deprivation; Treatment Outcome | 2011 |
Beneficial effect of donepezil on obstructive sleep apnea: a double-blind, placebo-controlled clinical trial.
Topics: Adult; Aged; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Humans; Indans; Male; Middle Aged; Oxygen; Piperidines; Placebos; Polysomnography; Sleep Apnea, Obstructive; Sleep Stages; Treatment Outcome | 2012 |
[Effects of donepezil treatment on platelets α and β secretase activities in Alzheimer's disease patients].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid Precursor Protein Secretases; Blood Platelets; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Piperidines; Treatment Outcome | 2011 |
Donepezil and memantine for moderate-to-severe Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Synergism; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Kaplan-Meier Estimate; Male; Memantine; Patient Dropouts; Piperidines; Psychological Tests; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2012 |
[Achetylcholinesterase (AChE) inhibition and serum lipokines in Alzheimer's disease: friend or foe?].
Topics: Adipokines; Adiponectin; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Appetite; Biomarkers; Body Mass Index; Cholesterol, HDL; Cholesterol, LDL; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Female; Humans; Hungary; Indans; Leptin; Lipid Metabolism; Male; Middle Aged; Nootropic Agents; Outpatients; Piperidines; Polymorphism, Single Nucleotide; Severity of Illness Index; Time Factors; Treatment Outcome; Triglycerides; Waist Circumference | 2012 |
Cardiac safety of donepezil in elderly patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Blood Pressure; Cholinesterase Inhibitors; Donepezil; Electrocardiography; Female; Gastrointestinal Diseases; Heart Rate; Humans; Hypotension; Indans; Male; Nootropic Agents; Piperidines | 2012 |
Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Brain Mapping; Cognition; Donepezil; Dopamine Agents; Female; Humans; Indans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Memantine; Neuropsychological Tests; Nootropic Agents; Oxygen; Piperidines; Regression Analysis | 2012 |
Effects of Chinese medicine for tonifying the kidney and resolving phlegm and blood stasis in treating patients with amnestic mild cognitive impairment: a randomized, double-blind and parallel-controlled trial.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Donepezil; Double-Blind Method; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Middle Aged; Phytotherapy; Piperidines; Treatment Outcome | 2012 |
Efficacy and safety of donepezil 23 mg versus donepezil 10 mg for moderate-to-severe Alzheimer's disease: a subgroup analysis in patients already taking or not taking concomitant memantine.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Geriatric Assessment; Humans; Indans; Intelligence Tests; Male; Memantine; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2012 |
Cognitive effects of the acetylcholinesterase inhibitor, donepezil, in healthy, non-treatment seeking smokers: a pilot feasibility study.
Topics: Adult; Analysis of Variance; Attention; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Feasibility Studies; Female; Humans; Indans; Male; Medication Adherence; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Piperidines; Psychomotor Performance; Reaction Time; Smoking | 2012 |
Donepezil combined with natural hirudin improves the clinical symptoms of patients with mild-to-moderate Alzheimer's disease: a 20-week open-label pilot study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Hirudins; Humans; Indans; Male; Nootropic Agents; Pilot Projects; Piperidines | 2012 |
Long-term safety and tolerability of donepezil 23 mg in patients with moderate to severe Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Ambulatory Care; Biomarkers, Pharmacological; Cognition; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Treatment Outcome | 2012 |
Effectiveness and safety of donepezil in boys with fragile x syndrome: a double-blind, randomized, controlled pilot study.
Topics: Adolescent; Child; Child Behavior Disorders; Child Development Disorders, Pervasive; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Fragile X Syndrome; Humans; Indans; Intelligence; Male; Nootropic Agents; Personality Assessment; Pilot Projects; Piperidines; Stanford-Binet Test; Treatment Outcome | 2013 |
[Chinese herbal medicine for patients with mild to moderate Alzheimer disease based on syndrome differentiation: a randomized controlled trial].
Topics: Alzheimer Disease; Cognition; Donepezil; Drugs, Chinese Herbal; Humans; Indans; Nootropic Agents; Piperidines | 2012 |
The effect of stimulation therapy and donepezil on cognitive function in Alzheimer's disease. A community based RCT with a two-by-two factorial design.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Combined Modality Therapy; Comorbidity; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Norway; Physical Therapy Modalities; Piperidines; Prevalence; Treatment Outcome | 2012 |
Donepezil for dementia with Lewy bodies: a randomized, placebo-controlled trial.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Humans; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2012 |
Donepezil in Parkinson's disease dementia: a randomized, double-blind efficacy and safety study.
Topics: Adult; Aged; Aged, 80 and over; Analysis of Variance; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Europe; Female; Humans; Indans; Male; Middle Aged; Parkinson Disease; Piperidines; Psychiatric Status Rating Scales | 2012 |
Subgroup analysis of US and non-US patients in a global study of high-dose donepezil (23 mg) in moderate and severe Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Analysis of Variance; Apolipoproteins E; Donepezil; Dopamine Agents; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Memantine; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; United States | 2012 |
The ASCOMALVA trial: association between the cholinesterase inhibitor donepezil and the cholinergic precursor choline alphoscerate in Alzheimer's disease with cerebrovascular injury: interim results.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Disorders; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Glycerylphosphorylcholine; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Piperidines; Treatment Outcome | 2012 |
Effect of CYP2D6*10 and APOE polymorphisms on the efficacy of donepezil in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Cognition; Cytochrome P-450 CYP2D6; Donepezil; Female; Follow-Up Studies; Gene Frequency; Humans; Indans; Male; Middle Aged; Mutation; Nootropic Agents; Piperidines; Polymorphism, Restriction Fragment Length | 2013 |
Functional response to cholinesterase inhibitor therapy in a naturalistic Alzheimer's disease cohort.
Topics: Activities of Daily Living; Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Disabled Persons; Donepezil; Female; Galantamine; Humans; Indans; Linear Models; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2012 |
Auditory cortical function during verbal episodic memory encoding in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Attention; Auditory Cortex; Auditory Perceptual Disorders; Cognitive Dysfunction; Donepezil; Female; Humans; Indans; Limbic System; Magnetic Resonance Imaging; Male; Memory Disorders; Memory, Episodic; Mental Recall; Middle Aged; Nootropic Agents; Piperidines; Verbal Learning; Young Adult | 2013 |
Effect of polymer, plasticizer and filler on orally disintegrating film.
Topics: Administration, Oral; Alzheimer Disease; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Stability; Drug Storage; Excipients; Female; Humans; Indans; Male; Medication Adherence; Piperidines; Plasticizers; Polymers; Solubility; Tablets; Tensile Strength; Time Factors; Young Adult | 2014 |
Donepezil treatment stabilizes functional connectivity during resting state and brain activity during memory encoding in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Magnetic Resonance Imaging; Memory; Piperidines; Time Factors | 2013 |
Cholinergic enhancement of functional networks in older adults with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Brain; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Double-Blind Method; Female; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Nerve Net; Photic Stimulation; Piperidines; Reaction Time; Up-Regulation | 2013 |
Effect of cholinergic neurotransmission modulation on visual spatial paired associate learning in healthy human adults.
Topics: Adolescent; Adult; Cholinesterase Inhibitors; Cognition Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Executive Function; Humans; Indans; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Paired-Associate Learning; Piperidines; Scopolamine; Time Factors; Young Adult | 2013 |
[Clinical research of early intervention of modified shuyu pill in vascular cognitive impairment no dementia].
Topics: Aged; Cognition Disorders; Donepezil; Drugs, Chinese Herbal; Early Medical Intervention; Female; Humans; Indans; Male; Middle Aged; Piperidines | 2013 |
Concentration of donepezil to the cognitive response in Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Memory, Long-Term; Nootropic Agents; Piperidines; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2013 |
Acute mood effect of donepezil in young, healthy volunteers.
Topics: Adult; Affect; Anxiety; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Indans; Male; Piperidines; Surveys and Questionnaires; Young Adult | 2013 |
Evaluating the cognitive effects of donepezil 23 mg/d in moderate and severe Alzheimer's disease: analysis of effects of baseline features on treatment response.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Piperidines; Severity of Illness Index; Treatment Outcome | 2013 |
Add-on clinical effects of selective antagonist of 5HT6 receptors AVN-211 (CD-008-0173) in patients with schizophrenia stabilized on antipsychotic treatment: pilot study.
Topics: Adult; Animals; Antipsychotic Agents; Attention; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred BALB C; Middle Aged; Pilot Projects; Piperidines; Prepulse Inhibition; Pyrazoles; Pyrimidines; Reaction Time; Receptors, Serotonin; Reflex, Startle; Schizophrenia; Schizophrenic Psychology; Scopolamine; Serotonin Antagonists; Tacrine; Treatment Outcome; Young Adult | 2014 |
Cognitive change in donepezil treated patients with vascular or mixed dementia.
Topics: Aged; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2013 |
Long-term safety and efficacy of donepezil in patients with dementia with Lewy bodies: results from a 52-week, open-label, multicenter extension study.
Topics: Aged; Aged, 80 and over; Data Interpretation, Statistical; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Lewy Body Disease; Male; Nootropic Agents; Parkinson Disease; Piperidines; Treatment Outcome | 2013 |
Evaluation of an 8-item Severe Impairment Battery (SIB-8) vs. the full SIB in moderate to severe Alzheimer's disease patients participating in a donepezil study.
Topics: Activities of Daily Living; Alzheimer Disease; Analysis of Variance; Cognition Disorders; Donepezil; Double-Blind Method; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2013 |
Differential effects of current specific treatments on behavioral and psychological symptoms in patients with Alzheimer's disease: a 12-month, randomized, open-label trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Behavioral Symptoms; Cholinesterase Inhibitors; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Female; Galantamine; Humans; Indans; Longitudinal Studies; Male; Memantine; Mental Disorders; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Rivastigmine | 2014 |
Effect of donepezil in Alzheimer disease can be measured by a computerized human analog of the Morris water maze.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Computers; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Pilot Projects; Piperidines; Spatial Behavior | 2014 |
Pharmacodynamics of cholinesterase inhibitors suggests add-on therapy with a low-dose carbamylating inhibitor in patients on long-term treatment with rapidly reversible inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Benzothiazoles; Blotting, Western; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Drug Therapy, Combination; Fluorescence; Follow-Up Studies; Humans; Indans; Physostigmine; Piperidines; Thiazoles; Time Factors | 2014 |
Donepezil provides positive effects to patients treated with gabapentin for neuropathic pain: an exploratory study.
Topics: Adult; Aged; Algorithms; Amines; Analgesics; Cyclohexanecarboxylic Acids; Cyclohexanols; Donepezil; Drug Therapy, Combination; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Male; Middle Aged; Neuralgia; Neuroprotective Agents; Pain Measurement; Piperidines; Quality of Life; Sample Size; Venlafaxine Hydrochloride | 2014 |
Brain-derived neurotrophic factor levels in late-life depression and comorbid mild cognitive impairment: a longitudinal study.
Topics: Aged; Aged, 80 and over; Antidepressive Agents; Brain-Derived Neurotrophic Factor; Cognitive Dysfunction; Depression; Donepezil; Enzyme-Linked Immunosorbent Assay; Female; Humans; Indans; Linear Models; Longitudinal Studies; Male; Piperidines; Time Factors | 2014 |
Donepezil treatment of older adults with cognitive impairment and depression (DOTCODE study): clinical rationale and design.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Depressive Disorder; Donepezil; Double-Blind Method; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Piperidines; Research Design | 2014 |
Efficacy and safety evaluation of HSD-1 inhibitor ABT-384 in Alzheimer's disease.
Topics: Adamantane; Aged; Alzheimer Disease; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperazines; Piperidines; Treatment Outcome | 2014 |
Population pharmacokinetic approach to evaluate the effect of CYP2D6, CYP3A, ABCB1, POR and NR1I2 genotypes on donepezil clearance.
Topics: Aged; Aged, 80 and over; Alleles; ATP Binding Cassette Transporter, Subfamily B; Cross-Sectional Studies; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Donepezil; Female; Genotype; Humans; Indans; Male; Middle Aged; Models, Biological; NADPH-Ferrihemoprotein Reductase; Piperidines; Pregnane X Receptor; Receptors, Steroid | 2014 |
The effects of combine treatment of memantine and donepezil on Alzheimer's disease patients and its relationship with cerebral blood flow in the prefrontal area.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brief Psychiatric Rating Scale; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Cost of Illness; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Prefrontal Cortex; Spectroscopy, Near-Infrared | 2014 |
Parallel improvement of cognitive functions and P300 latency following donepezil treatment in patients with Alzheimer's disease: a case-control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Cognition; Donepezil; Event-Related Potentials, P300; Evoked Potentials; Female; Humans; Indans; Male; Piperidines | 2014 |
Taste-masked and affordable donepezil hydrochloride orally disintegrating tablet as promising solution for non-compliance in Alzheimer's disease patients.
Topics: Adult; Alzheimer Disease; Donepezil; Double-Blind Method; Drug Compounding; Drug Costs; Drug Delivery Systems; Drug Liberation; Drug Stability; Drug Storage; Excipients; Glycyrrhizic Acid; Hardness; Humans; Indans; Mouth Mucosa; Nootropic Agents; Patient Preference; Piperidines; Salvia; Sweetening Agents; Tablets; Taste; Taste Perception | 2015 |
Retrospective study on the benefits of combined Memantine and cholinEsterase inhibitor treatMent in AGEd Patients affected with Alzheimer's Disease: the MEMAGE study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Comorbidity; Donepezil; Female; Galantamine; Humans; Indans; Italy; Male; Memantine; Middle Aged; Nootropic Agents; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Retrospective Studies; Rivastigmine; Time Factors; Treatment Outcome | 2014 |
The ASCOMALVA (Association between the Cholinesterase Inhibitor Donepezil and the Cholinergic Precursor Choline Alphoscerate in Alzheimer's Disease) Trial: interim results after two years of treatment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Antipsychotic Agents; Donepezil; Double-Blind Method; Female; Glycerylphosphorylcholine; Humans; Indans; Longitudinal Studies; Male; Mental Status Schedule; Middle Aged; Piperidines; Severity of Illness Index | 2014 |
A randomized study of H3 antagonist ABT-288 in mild-to-moderate Alzheimer's dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Follow-Up Studies; Histamine H3 Antagonists; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Pyridazines; Pyrroles; Treatment Outcome | 2014 |
Donepezil improves gait performance in older adults with mild Alzheimer's disease: a phase II clinical trial.
Topics: Aged; Alzheimer Disease; Anti-Dyskinesia Agents; Attention; Cholinesterase Inhibitors; Donepezil; Executive Function; Female; Gait; Gait Disorders, Neurologic; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2015 |
The effect of a combination of gabapentin and donepezil in an experimental pain model in healthy volunteers: Results of a randomized controlled trial.
Topics: Adolescent; Adult; Amines; Analgesics, Non-Narcotic; Cross-Over Studies; Cyclohexanecarboxylic Acids; Donepezil; Double-Blind Method; Drug Therapy, Combination; Electric Stimulation; Female; Follow-Up Studies; Gabapentin; gamma-Aminobutyric Acid; Healthy Volunteers; Humans; Indans; Male; Middle Aged; Nootropic Agents; Pain; Pain Measurement; Piperidines; Skin; Sural Nerve; Young Adult | 2014 |
Safety and efficacy of idalopirdine, a 5-HT6 receptor antagonist, in patients with moderate Alzheimer's disease (LADDER): a randomised, double-blind, placebo-controlled phase 2 trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Benzylamines; Cognition Disorders; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Indoles; Male; Nootropic Agents; Piperidines; Receptors, Serotonin; Serotonin Antagonists; Treatment Outcome | 2014 |
Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Apolipoprotein E4; Biomarkers; Blood Chemical Analysis; Cognitive Dysfunction; Disease Progression; Donepezil; Female; Heterozygote; Humans; Indans; Longitudinal Studies; Male; Nootropic Agents; Peptide Fragments; Piperidines; Severity of Illness Index; Simvastatin; Vitamin E | 2015 |
Management of cognitive determinants in senile dementia of Alzheimer's type: therapeutic potential of a novel polyherbal drug product.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Disease Management; Donepezil; Double-Blind Method; Drug Combinations; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Plant Components, Aerial; Plant Extracts; Plant Preparations | 2014 |
Antidementia drug treatment in people screened positive for dementia in primary care.
Topics: Aged; Aged, 80 and over; Dementia; Donepezil; Female; Galantamine; Humans; Indans; Male; Memantine; Mental Status Schedule; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Primary Health Care; Rivastigmine | 2015 |
The effectiveness of reality orientation in the treatment of Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Combined Modality Therapy; Donepezil; Female; Humans; Indans; Male; Neurological Rehabilitation; Neuropsychological Tests; Orientation; Piperidines; Severity of Illness Index; Treatment Outcome | 2015 |
Donepezil decreases annual rate of hippocampal atrophy in suspected prodromal Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Atrophy; Disease Progression; Donepezil; Double-Blind Method; Female; France; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Male; Neuroprotective Agents; Organ Size; Piperidines; Prodromal Symptoms; Treatment Outcome | 2015 |
Cholinergic modulation of stimulus-driven attentional capture.
Topics: Adult; Attention; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Photic Stimulation; Piperidines; Reaction Time; Visual Perception; Young Adult | 2015 |
[Nourishing Xin and Shen method improved mild cognitive impairment due to subcortical small vessel disease: a clinical study].
Topics: Alzheimer Disease; Biomedical Research; Cognition; Cognitive Dysfunction; Dementia; Donepezil; Drugs, Chinese Herbal; Humans; Indans; Neuropsychological Tests; Piperidines | 2015 |
Single dose pharmacokinetics of the novel transdermal donepezil patch in healthy volunteers.
Topics: Administration, Cutaneous; Adult; Chromatography, Liquid; Donepezil; Drug Tolerance; Healthy Volunteers; Humans; Indans; Male; Middle Aged; Piperidines; Single-Blind Method; Tandem Mass Spectrometry; Transdermal Patch; Young Adult | 2015 |
Donepezil for Irradiated Brain Tumor Survivors: A Phase III Randomized Placebo-Controlled Clinical Trial.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cholinesterase Inhibitors; Cognition Disorders; Combined Modality Therapy; Donepezil; Double-Blind Method; Female; Humans; Indans; Learning; Male; Memory; Middle Aged; Neoplasm Metastasis; Neuropsychological Tests; Piperidines; Treatment Outcome; Young Adult | 2015 |
Effect of ninjin'yoeito, a Kampo (traditional Japanese) medicine, on cognitive impairment and depression in patients with Alzheimer's disease: 2 years of observation.
Topics: Affect; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Depression; Donepezil; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Medicine, Kampo; Panax; Piperidines; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2016 |
Therapeutic dosage assessment based on population pharmacokinetics of a novel single-dose transdermal donepezil patch in healthy volunteers.
Topics: Adult; Cholinesterase Inhibitors; Donepezil; Healthy Volunteers; Humans; Indans; Male; Models, Biological; Piperidines; Transdermal Patch; Young Adult | 2015 |
A novel once-daily fixed-dose combination of memantine extended release and donepezil for the treatment of moderate to severe Alzheimer's disease: two phase I studies in healthy volunteers.
Topics: Adult; Alzheimer Disease; Biological Availability; Cross-Over Studies; Donepezil; Drug Therapy, Combination; Female; Healthy Volunteers; Humans; Indans; Male; Memantine; Piperidines | 2015 |
The Effect of Memantine on Cognitive Function and Behavioral and Psychological Symptoms in Mild-to-Moderate Alzheimer's Disease Patients.
Topics: Alzheimer Disease; Behavioral Symptoms; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Male; Memantine; Neuropsychological Tests; Piperidines; Prospective Studies; Severity of Illness Index | 2015 |
Cognitive Improvement during Treatment for Mild Alzheimer's Disease with a Chinese Herbal Formula: A Randomized Controlled Trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; China; Cognition; Donepezil; Double-Blind Method; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Piperidines; Treatment Outcome | 2015 |
A study of donepezil in female breast cancer survivors with self-reported cognitive dysfunction 1 to 5 years following adjuvant chemotherapy.
Topics: Adult; Affect; Aged; Breast Neoplasms; Chemotherapy, Adjuvant; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Fatigue; Feasibility Studies; Female; Humans; Indans; Memory; Middle Aged; Pilot Projects; Piperidines; Quality of Life; Self Report; Survivors | 2016 |
Effects of Donepezil on Extrapyramidal Symptoms in Patients with Dementia with Lewy Bodies: A Secondary Pooled Analysis of Two Randomized-Controlled and Two Open-Label Long-Term Extension Studies.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Datasets as Topic; Disease Progression; Donepezil; Female; Humans; Indans; Lewy Body Disease; Logistic Models; Longitudinal Studies; Male; Neuropsychological Tests; Piperidines | 2015 |
Low-Dose Atypical Antipsychotic Risperidone Improves the 5-Year Outcome in Alzheimer's Disease Patients with Sleep Disturbances.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Caregivers; Donepezil; Female; Humans; Hypnotics and Sedatives; Indans; Male; Melatonin; Neuropsychological Tests; Nootropic Agents; Nursing Homes; Piperidines; Polysomnography; Pyridines; Risperidone; Sleep Wake Disorders; Treatment Outcome; Zolpidem | 2015 |
Combined therapy of Di-Huang-Yi-Zhi with Donepezil in patients with Parkinson's disease dementia.
Topics: Aged; Aged, 80 and over; Case-Control Studies; Dementia; Donepezil; Double-Blind Method; Drug Therapy, Combination; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Middle Aged; Parkinson Disease; Piperidines | 2015 |
Selective Ability of Some CANTAB Battery Test Measures to Detect Cognitive Response to a Single Dose of Donepezil in Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cognition; Cognition Disorders; Donepezil; Female; Humans; Indans; Learning; Male; Memory; Neuropsychological Tests; Pattern Recognition, Visual; Piperidines; Prospective Studies; Psychometrics; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
Apathy Treatment in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.
Topics: Aged; Alzheimer Disease; Apathy; Caregivers; Cholinergic Agents; Donepezil; Double-Blind Method; Drug Therapy, Combination; Female; Glycerylphosphorylcholine; Humans; Indans; Male; Piperidines; Psychiatric Status Rating Scales; Psychotropic Drugs; Time Factors; Treatment Outcome | 2015 |
Effects of the Acetylcholine Release Agent ST101 with Donepezil in Alzheimer's Disease: A Randomized Phase 2 Study.
Topics: Alzheimer Disease; Cholinergic Agents; Cognition; Donepezil; Double-Blind Method; Drug Therapy, Combination; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Piperidines; Spiro Compounds; Treatment Outcome | 2015 |
APOE-ɛ4 Carrier Status and Donepezil Response in Patients with Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Cholinesterase Inhibitors; Cognition; Donepezil; Double-Blind Method; Female; Genotype; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales | 2015 |
Nursing home placement in the Donepezil and Memantine in Moderate to Severe Alzheimer's Disease (DOMINO-AD) trial: secondary and post-hoc analyses.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Double-Blind Method; Female; Homes for the Aged; Humans; Indans; Male; Memantine; Neuropsychological Tests; Nootropic Agents; Nursing Homes; Piperidines; Severity of Illness Index | 2015 |
Adequacy of Using Consensus Guidelines for Diagnosis of Dementia with Lewy Bodies in Clinical Trials for Drug Development.
Topics: Aged; Aged, 80 and over; Consensus; Dementia; Donepezil; Female; Guideline Adherence; Humans; Indans; Lewy Body Disease; Male; Piperidines; Practice Guidelines as Topic; Psychiatric Status Rating Scales | 2016 |
Cognitive Results of CANTAB Tests and Their Change Due to the First Dose of Donepezil May Predict Treatment Efficacy in Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Prospective Studies; Treatment Outcome | 2015 |
Effect of augmenting cholinergic function on gait and balance.
Topics: Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Gait Disorders, Neurologic; Humans; Indans; Parkinson Disease; Piperidines; Postural Balance | 2015 |
Predictors of cognitive decline and treatment response in a clinical trial on suspected prodromal Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognitive Dysfunction; Cross-Sectional Studies; Disease Progression; Donepezil; Double-Blind Method; Female; Follow-Up Studies; Humans; Indans; Magnetic Resonance Imaging; Male; Nootropic Agents; Piperidines; Predictive Value of Tests; Prodromal Symptoms; Treatment Outcome | 2016 |
Donepezil 23 mg in Asian patients with moderate-to-severe Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Nausea; Piperidines; Severity of Illness Index; Treatment Outcome | 2017 |
Donepezil plasma concentrations, CYP2D6 and CYP3A4 phenotypes, and cognitive outcome in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cholinesterase Inhibitors; Cognition; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Donepezil; Drug Interactions; Female; Humans; Indans; Male; Phenotype; Piperidines | 2016 |
Efficacy and Safety of ABT-126 in Subjects with Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors: A Randomized, Double-Blind, Placebo-Controlled Study.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; International Cooperation; Male; Medication Adherence; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2016 |
Efficacy and Safety of Sustained Release Donepezil High Dose versus Immediate Release Donepezil Standard Dose in Japanese Patients with Severe Alzheimer's Disease: A Randomized, Double-Blind Trial.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Delayed-Action Preparations; Donepezil; Double-Blind Method; Female; Humans; Indans; Japan; Male; Mental Status Schedule; Nootropic Agents; Outpatients; Piperidines; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 2016 |
Increased plasma donepezil concentration improves cognitive function in patients with dementia with Lewy bodies: An exploratory pharmacokinetic/pharmacodynamic analysis in a phase 3 randomized controlled trial.
Topics: Aged; Aged, 80 and over; Blood Pressure; Body Weight; Cognition; Cytochrome P-450 CYP2D6; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Lewy Body Disease; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Pulse; Severity of Illness Index; Treatment Outcome | 2016 |
Cocaine cardiovascular effects and pharmacokinetics after treatment with the acetylcholinesterase inhibitor donepezil.
Topics: Administration, Oral; Adult; Biological Availability; Cardiovascular System; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Premedication; Treatment Outcome | 2016 |
The Effect of Donepezil on Arousal Threshold and Apnea-Hypopnea Index. A Randomized, Double-Blind, Cross-Over Study.
Topics: Adult; Arousal; California; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Middle Aged; Oximetry; Piperidines; Polysomnography; Respiratory System; Severity of Illness Index; Sleep; Sleep Apnea, Obstructive; Treatment Outcome | 2016 |
Pretreatment Cognitive Profile Likely to Benefit from Donepezil Treatment in Dementia with Lewy Bodies: Pooled Analyses of Two Randomized Controlled Trials.
Topics: Aged; Cognition; Donepezil; Drug Monitoring; Female; Humans; Indans; Lewy Body Disease; Male; Mental Recall; Mental Status and Dementia Tests; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2016 |
Butyrylcholinesterase K and Apolipoprotein E-ɛ4 Reduce the Age of Onset of Alzheimer's Disease, Accelerate Cognitive Decline, and Modulate Donepezil Response in Mild Cognitively Impaired Subjects.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E4; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Piperidines; Quebec; Treatment Outcome | 2016 |
Concentration of Donepezil in the Cerebrospinal Fluid of AD Patients: Evaluation of Dosage Sufficiency in Standard Treatment Strategy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood-Brain Barrier; Capillary Permeability; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Spinal Puncture; Time Factors | 2017 |
Cost-effectiveness of donepezil and memantine in moderate to severe Alzheimer's disease (the DOMINO-AD trial).
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cost-Benefit Analysis; Donepezil; Double-Blind Method; England; Female; Health Care Costs; Humans; Indans; Memantine; Piperidines; Quality of Life; Wales | 2017 |
ABT-126 monotherapy in mild-to-moderate Alzheimer's dementia: randomized double-blind, placebo and active controlled adaptive trial and open-label extension.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinergic Agonists; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Piperidines; Quinuclidines; Thiadiazoles; Treatment Outcome | 2016 |
Reduced Regional Cortical Thickness Rate of Change in Donepezil-Treated Subjects With Suspected Prodromal Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Cerebral Cortex; Cognitive Dysfunction; Disease Progression; Donepezil; Double-Blind Method; Female; Humans; Indans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nootropic Agents; Outcome Assessment, Health Care; Piperidines; Prodromal Symptoms | 2016 |
Scopolamine disrupts place navigation in rats and humans: a translational validation of the Hidden Goal Task in the Morris water maze and a real maze for humans.
Topics: Adult; Animals; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Maze Learning; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Spatial Navigation; Young Adult | 2017 |
The Effect of the Association between Donepezil and Choline Alphoscerate on Behavioral Disturbances in Alzheimer's Disease: Interim Results of the ASCOMALVA Trial.
Topics: Aged; Alzheimer Disease; Anxiety; Apathy; Caregivers; Depression; Donepezil; Double-Blind Method; Female; Glycerylphosphorylcholine; Humans; Indans; Male; Piperidines; Psychotropic Drugs; Severity of Illness Index; Stress, Psychological; Treatment Outcome | 2017 |
Donepezil Plus Solifenacin (CPC-201) Treatment for Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Maximum Tolerated Dose; Middle Aged; Muscarinic Antagonists; Piperidines; Single-Blind Method; Solifenacin Succinate; Treatment Outcome | 2017 |
Efficacy and Safety of Donepezil in Chinese Patients with Severe Alzheimer's Disease: A Randomized Controlled Trial.
Topics: Aged; Alzheimer Disease; China; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Male; Mental Status and Dementia Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2017 |
Auditory training changes temporal lobe connectivity in 'Wernicke's aphasia': a randomised trial.
Topics: Aphasia, Wernicke; Auditory Perception; Cholinesterase Inhibitors; Comprehension; Donepezil; Double-Blind Method; Female; Humans; Indans; Magnetoencephalography; Male; Middle Aged; Neuropsychological Tests; Piperidines; Speech Perception; Temporal Lobe | 2017 |
Adherence and Tolerability of Alzheimer's Disease Medications: A Pragmatic Randomized Trial.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Costs; Drug-Related Side Effects and Adverse Reactions; Ethnicity; Female; Galantamine; Humans; Indans; Indiana; Male; Medication Adherence; Piperidines; Rivastigmine | 2017 |
Aβ levels in the jugular vein and high molecular weight Aβ oligomer levels in CSF can be used as biomarkers to indicate the anti-amyloid effect of IVIg for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Biomarkers; Brain; Cognition; Donepezil; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Indans; Jugular Veins; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Piperidines; Positron-Emission Tomography; Seizures; Treatment Outcome | 2017 |
Adverse Events With Sustained-Release Donepezil in Alzheimer Disease: Relation to Body Mass Index.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Body Mass Index; Body Weight; Cholinesterase Inhibitors; Delayed-Action Preparations; Dizziness; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nausea; Piperidines; Prospective Studies; Republic of Korea | 2017 |
The effect of electroacupuncture combined with donepezil on cognitive function in Alzheimer's disease patients: study protocol for a randomized controlled trial.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; China; Clinical Protocols; Cognition; Combined Modality Therapy; Donepezil; Electroacupuncture; Female; Humans; Indans; Male; Mental Status and Dementia Tests; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Prospective Studies; Research Design; Surveys and Questionnaires; Time Factors; Treatment Outcome | 2017 |
Changes in brain amyloid-β accumulation after donepezil administration.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Peptides; Aniline Compounds; Brain; Donepezil; Female; Functional Neuroimaging; Humans; Indans; Male; Nootropic Agents; Piperidines; Positron-Emission Tomography; Thiazoles; Time Factors | 2017 |
Acupuncture for patients with mild to moderate Alzheimer's disease: a randomized controlled trial.
Topics: Acupuncture Therapy; Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Mental Status and Dementia Tests; Piperidines; Treatment Outcome | 2017 |
Effect of Idalopirdine as Adjunct to Cholinesterase Inhibitors on Change in Cognition in Patients With Alzheimer Disease: Three Randomized Clinical Trials.
Topics: Accidental Falls; Aged; Aged, 80 and over; Alzheimer Disease; Benzylamines; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Female; Galantamine; Humans; Indans; Indoles; Male; Middle Aged; Piperidines; Rivastigmine; Serotonin Antagonists; Treatment Failure | 2018 |
Efficacy of Donepezil in the Treatment of Obstructive Sleep Apnea: A Placebo-Controlled Trial.
Topics: Adult; Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Prospective Studies; Sleep Apnea, Obstructive | 2016 |
Early-start
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Double-Blind Method; Humans; Indans; Parkinson Disease; Piperidines; Treatment Outcome | 2021 |
Safety and Pharmacokinetics of HTL0018318, a Novel M
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Humans; Indans; Piperidines | 2021 |
Effects of Body Weight on the Safety of High-Dose Donepezil in Alzheimer's Disease: Post hoc Analysis of a Multicenter, Randomized, Open-Label, Parallel Design, Three-Arm Clinical Trial.
Topics: Alzheimer Disease; Body Weight; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Indans; Piperidines; Treatment Outcome | 2021 |
Impact of Donepezil and Memantine on Behavioral and Psychological Symptoms of Alzheimer Disease: Six-month Open-label Study.
Topics: Alzheimer Disease; Behavioral Symptoms; Donepezil; Humans; Indans; Memantine; Piperidines; Prospective Studies; Treatment Outcome | 2021 |
Effect of Resveratrol Combined with Donepezil Hydrochloride on Inflammatory Factor Level and Cognitive Function Level of Patients with Alzheimer's Disease.
Topics: Alzheimer Disease; Cognition; Donepezil; Humans; Indans; Piperidines; Resveratrol | 2022 |
The measured CSF/plasma donepezil concentration ratio but not individually measured CSF and plasma concentrations significantly increase over 24 h after donepezil treatment in patients with Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2023 |
Efficacy and safety of a transdermal donepezil patch in patients with mild-to-moderate Alzheimer's disease: A 24-week, randomized, multicenter, double-blind, parallel group, non-inferiority study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Humans; Indans; Piperidines; Treatment Outcome | 2023 |
Comment on "Efficacy and safety of a transdermal donepezil patch in patients with mild-to-moderate Alzheimer's disease: A 24-week, randomized, multicenter, double-blind, parallel-group, non-inferiority study".
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Piperidines | 2023 |
Efficacy and Safety of a Transdermal Donepezil Patch in Patients with Mild to Moderate Alzheimer's Disease: Open-Label, Extension Study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Humans; Indans; Piperidines; Treatment Outcome | 2023 |
1401 other study(ies) available for donepezil and piperidines
| Article | Year |
|---|---|
Determination of enantiomers of 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020), a centrally acting acetylcholine esterase inhibitor, in plasma by liquid chromatography with fluorometric detection.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Piperidines; Rats; Reproducibility of Results; Spectrometry, Fluorescence; Stereoisomerism | 1992 |
Synthesis and structure-activity relationships of acetylcholinesterase inhibitors: 1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine hydrochloride and related compounds.
Topics: Animals; Binding Sites; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Male; Mice; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship | 1995 |
Direct determination of E2020 enantiomers in plasma by liquid chromatography-mass spectrometry and column-switching techniques.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dogs; Donepezil; Gas Chromatography-Mass Spectrometry; Indans; Male; Piperidines; Reproducibility of Results; Spectrometry, Mass, Fast Atom Bombardment; Spectrophotometry, Ultraviolet; Stereoisomerism | 1995 |
Prediction of the binding site of 1-benzyl-4-[(5,6-dimethoxy-1-indanon-2-yl)methyl]piperidine in acetylcholinesterase by docking studies with the SYSDOC program.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Computer-Aided Design; Donepezil; Drug Design; Humans; In Vitro Techniques; Indans; Models, Molecular; Molecular Conformation; Piperidines; Software; Stereoisomerism | 1994 |
Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Male; Movement; Physostigmine; Piperidines; Radioimmunoassay; Rats; Rats, Wistar; Tacrine | 1994 |
Acetylcholinesterase protection and the anti-diisopropylfluorophosphate efficacy of E2020.
Topics: Acetylcholinesterase; Acetylthiocholine; Animals; Atropine; Cholinesterase Inhibitors; Donepezil; Electrophorus; Hydrolysis; Indans; Isoflurophate; Male; Mice; Piperidines | 1994 |
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory.
Topics: Animals; Avoidance Learning; Bridged Bicyclo Compounds; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Conditioning, Classical; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Memory; Mice; Oxadiazoles; Pain Threshold; Parasympathomimetics; Physostigmine; Piperidines; Pyrazines; Quinuclidines; Rats; Receptors, Muscarinic; Thiophenes | 1993 |
Kinetic study on the inhibition of acetylcholinesterase by 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride (E2020).
Topics: Acetylcholinesterase; Brain; Catalysis; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Piperidines | 1995 |
The effect of the selective reversible acetylcholinesterase inhibitor E2020 on extracellular acetylcholine and biogenic amine levels in rat cortex.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Biogenic Monoamines; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dopamine; Indans; Male; Microdialysis; Norepinephrine; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin | 1996 |
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors.
Topics: Amnesia; Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Motor Activity; Muscarinic Antagonists; Physostigmine; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1996 |
The simulated binding of (+/-)-2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]meth yl] -1H-inden-1-one hydrochloride (E2020) and related inhibitors to free and acylated acetylcholinesterases and corresponding structure-activity analyses.
Topics: Acetylcholine; Acetylcholinesterase; Acylation; Binding Sites; Cholinesterase Inhibitors; Donepezil; Indans; Isomerism; Kinetics; Models, Molecular; Piperidines; Protein Conformation; Structure-Activity Relationship | 1996 |
The rationale for E2020 as a potent acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Indans; Models, Molecular; Piperidines; Protein Conformation; Software; Torpedo | 1996 |
Alzheimer's disease: new pharmacological perspectives.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Dihydropyridines; Donepezil; Humans; Indans; Muscarinic Agonists; Oximes; Phenylcarbamates; Piperidines; Pyridines; Rivastigmine; Tacrine; Thiadiazoles | 1996 |
From the Food and Drug Administration.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Computer Communication Networks; Donepezil; Drug Approval; Drug Information Services; Drug Labeling; Humans; Indans; Mammography; Medical Informatics; Piperidines; Publishing; United States; United States Food and Drug Administration | 1997 |
Huperzine A, a novel promising acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Alkaloids; Amnesia; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Indans; Kinetics; Male; Maze Learning; Memory; Memory, Short-Term; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1996 |
From mechanisms to drugs in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Dioxoles; Donepezil; Humans; Indans; Memory, Short-Term; Piperidines; Rats; Tacrine | 1997 |
New drug available for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 1997 |
Drug treatments for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Protocols; Donepezil; Ethics, Medical; Humans; Indans; Piperidines; Treatment Outcome | 1997 |
Advertisements for donepezil (Aricept) in the BMJ. Advertisement suggests an unrealistic improvement in mental status.
Topics: Advertising; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 1997 |
Advertisements for donepezil (Aricept) in the BMJ. Local committee has declined to approve NHS hospital prescription of donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Prescriptions; Humans; Indans; Piperidines | 1997 |
Donepezil (Aricept) for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Costs and Cost Analysis; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Piperidines | 1997 |
Functional activation of cerebral blood flow abolished by scopolamine is reversed by cognitive enhancers associated with cholinesterase inhibition: a positron emission tomography study in unanesthetized monkeys.
Topics: Animals; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Physostigmine; Piperidines; Scopolamine; Tacrine; Tomography, Emission-Computed | 1997 |
Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor E2020 in rhesus monkeys.
Topics: Acetylcholine; Analysis of Variance; Animals; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Macaca mulatta; Male; Memory; Piperidines | 1997 |
Effects of NIK-247 on cholinesterase and scopolamine-induced amnesia.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Amnesia; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Motor Activity; Piperidines; Psychotropic Drugs; Rats; Rats, Wistar; Scopolamine; Tacrine | 1997 |
Donepezil (Aricept) therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tacrine | 1997 |
Absence of central cholinergic deficits in ApoE knockout mice.
Topics: Acetylcholinesterase; Animals; Apolipoproteins E; Body Temperature; Brain; Choline O-Acetyltransferase; Cholinergic Agonists; Donepezil; Female; Indans; Male; Maze Learning; Mice; Mice, Knockout; Mice, Transgenic; Motor Activity; Piperidines; Receptors, Cholinergic | 1997 |
Donepezil, Alzheimer's disease and suxamethonium.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Humans; Indans; Neuromuscular Depolarizing Agents; Piperidines; Succinylcholine | 1997 |
A request for the 'Alzheimer's drug'.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Decision Making; Donepezil; Humans; Indans; Male; Piperidines; Referral and Consultation | 1997 |
Aricept-induced nightmares in Alzheimer's disease: 2 case reports.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dreams; Female; Humans; Indans; Male; Piperidines; Sleep Wake Disorders | 1998 |
Advertisements for donepezil. More convincing evidence of efficacy needs to be cited.
Topics: Advertising; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Industry; Humans; Indans; Piperidines | 1997 |
Advertisements for donepezil. BMJ should require advertisements to detail actual state of evidence.
Topics: Advertising; Cholinesterase Inhibitors; Donepezil; Evidence-Based Medicine; Humans; Indans; Piperidines | 1997 |
Advertisements for donepezil. National policy needs to be set for prescribing of this drug.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Health Policy; Humans; Indans; Piperidines | 1997 |
Advertisements for donepezil. Prices charged for private prescriptions for donepezil show huge variation.
Topics: Cholinesterase Inhibitors; Donepezil; Drug Costs; Humans; Indans; Piperidines; Prescription Fees | 1997 |
Advertisements for donepezil. Review of drug in Drug and Therapeutics Bulletin is uninformed.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Piperidines; Treatment Outcome | 1997 |
Donepezil medicated memory improvement in traumatic brain injury during post acute rehabilitation.
Topics: Adult; Alzheimer Disease; Brain Injuries; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Donepezil; Female; Head Injuries, Closed; Humans; Indans; Male; Memory; Memory Disorders; Mental Recall; Middle Aged; Physical Therapy Modalities; Physostigmine; Piperidines; Temporal Lobe | 1998 |
Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: a comparison with the cholinesterase inhibitor E2020.
Topics: 4-Aminopyridine; Animals; Apamin; Choice Behavior; Cholinesterase Inhibitors; Conditioning, Operant; Donepezil; Indans; Male; Muscarinic Antagonists; Piperidines; Potassium Channel Blockers; Potassium Channels; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Scopolamine | 1998 |
Drug and Therapeutics Bulletin defends its stance over donepezil.
Topics: Advertising; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Industry; Humans; Indans; Piperidines | 1998 |
Questions about donepezil.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Piperidines; Safety | 1998 |
Drug treatment for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Estrogen Replacement Therapy; Female; Humans; Indans; Male; Neuroprotective Agents; Piperidines; Selegiline; Vitamin E | 1998 |
Long-lasting antiamnesic effect of a novel anticholinesterase inhibitor (MF268).
Topics: Amnesia; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Indans; Male; Maze Learning; Morpholines; Motor Activity; Muscarinic Antagonists; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 1998 |
New drug treatments for Alzheimer disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 1998 |
Donepezil for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Humans; Indans; Middle Aged; Piperidines; Randomized Controlled Trials as Topic; Reproducibility of Results; Treatment Outcome | 1998 |
Combination of risperidone and donepezil in Lewy body dementia.
Topics: Aged; Antipsychotic Agents; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Therapy, Combination; Humans; Indans; Male; Parkinson Disease; Piperidines; Risperidone | 1998 |
Improving functioning in patients with Alzheimer's.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Treatment Outcome | 1998 |
Possible association between donepezil and worsening Parkinson's disease.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Disease Progression; Donepezil; Female; Humans; Indans; Parkinson Disease; Piperidines | 1998 |
Emerging antidementia drugs: a preliminary ethical view.
Topics: Aged; Alzheimer Disease; Beneficence; Cholinesterase Inhibitors; Dementia; Donepezil; Ethics, Medical; Female; Humans; Indans; Male; Nootropic Agents; Patient Care Planning; Piperidines; Professional-Family Relations; Quality of Life; Risk Assessment; Withholding Treatment | 1998 |
Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.
Topics: Adrenal Gland Neoplasms; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; Donepezil; Indans; Mecamylamine; Neurons; Neuroprotective Agents; Neurotoxins; Nicotinic Antagonists; PC12 Cells; Peptide Fragments; Pheochromocytoma; Piperidines; Rats; Tacrine; Tubocurarine | 1998 |
Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities.
Topics: Alkaloids; Animals; Aziridines; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Injections, Intraventricular; Male; Maze Learning; Memory; Memory, Short-Term; Neuromuscular Blocking Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Reversal of scopolamine-induced deficits in radial maze performance by (-)-huperzine A: comparison with E2020 and tacrine.
Topics: Alkaloids; Amnesia; Animals; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Sesquiterpenes; Tacrine | 1998 |
Donepezil: suspected adverse reactions.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Mixed Function Oxygenases; Piperidines | 1998 |
Advances in diagnosing and treating Alzheimer's disease.
Topics: Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tacrine | 1998 |
Purpuric rash with donepezil treatment.
Topics: Aged; Aged, 80 and over; Donepezil; Drug Eruptions; Female; Humans; Indans; Nootropic Agents; Piperidines; Purpura | 1998 |
New drug treatment for Alzheimer's disease. Doctors want to offer more than sympathy.
Topics: Alzheimer Disease; Clinical Trials as Topic; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Physician-Patient Relations; Piperidines | 1998 |
The amnestic prodrome of Alzheimer's disease.
Topics: Alzheimer Disease; Cognition; Donepezil; Education, Medical; Humans; Indans; Nootropic Agents; Piperidines; United States | 1998 |
Extrapyramidal side effects in a patient treated with risperidone plus donepezil.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Piperidines; Risperidone | 1998 |
Alzheimer's disease management.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Piperidines; Selegiline; Tacrine; Vitamin E | 1998 |
[18F]fluoroethoxy-benzovesamicol, a PET radiotracer for the vesicular acetylcholine transporter and cholinergic synapses.
Topics: Acetylcholine; Animals; Autoradiography; Brain; Calibration; Carrier Proteins; Cholinesterase Inhibitors; Donepezil; Dopamine Agonists; Female; Fluorine Radioisotopes; Haloperidol; Humans; Indans; Kinetics; Male; Membrane Transport Proteins; Mice; Organ Specificity; Piperidines; Rats; Rats, Sprague-Dawley; Stereoisomerism; Synapses; Tissue Distribution; Tomography, Emission-Computed; Vesicular Acetylcholine Transport Proteins; Vesicular Transport Proteins | 1998 |
Visual form of Alzheimer's disease and its response to anticholinesterase therapy.
Topics: Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Middle Aged; Neuropsychological Tests; Piperidines; Tomography, Emission-Computed, Single-Photon; Vision Disorders | 1998 |
[50th Annual Meeting of the American Academy of Neurology (AAN). Minneapolis, 25 April--2 May 1998. 151st Annual Meeting of the American Psychiatric Association (APA). Toronto, 31 May--3 June 1998].
Topics: Alzheimer Disease; Dementia; Diagnosis, Differential; Donepezil; Humans; Indans; Neurology; Nootropic Agents; Parkinson Disease; Piperidines; Psychiatry; Societies, Medical | 1998 |
The effects of donepezil and neostigmine in a patient with unusual pseudocholinesterase activity.
Topics: Aged; Aged, 80 and over; Anesthesia; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Female; Humans; Indans; Neostigmine; Neuromuscular Blockade; Neuromuscular Blocking Agents; Nootropic Agents; Piperidines | 1998 |
Violent behavior-associated with donepezil.
Topics: Aged; Aggression; Alzheimer Disease; Cholinesterase Inhibitors; Domestic Violence; Donepezil; Humans; Indans; Male; Paranoid Behavior; Parkinson Disease; Piperidines | 1998 |
Behavioral complications associated with donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Mental Disorders; Piperidines | 1998 |
Facilitatory effect of huperzine-A on mouse neuromuscular transmission in vitro.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; In Vitro Techniques; Indans; Male; Mice; Neuromuscular Junction; Piperidines; Sesquiterpenes; Synaptic Transmission; Taurine | 1996 |
Dementia with Lewy bodies: response of delirium-like features to donepezil.
Topics: Aged; Brain; Delirium; Dementia; Donepezil; Humans; Indans; Lewy Bodies; Magnetic Resonance Imaging; Male; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales | 1998 |
New drug treatment for Alzheimer's disease. Effects of drugs can be variable.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Treatment Outcome | 1998 |
New drug treatment for Alzheimer's disease. Drugs should not need to show cost effectiveness to justify their prescription.
Topics: Alzheimer Disease; Cost-Benefit Analysis; Donepezil; Drug Costs; Humans; Indans; Nootropic Agents; Piperidines | 1998 |
New drug treatment for Alzheimer's disease. SMAC's advice on use of donepezil is contradictory.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Practice Guidelines as Topic | 1998 |
New drug treatment for Alzheimer's disease. Treatment with metrifonate warrants multicentre trials.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Humans; Indans; Multicenter Studies as Topic; Nootropic Agents; Piperidines; Trichlorfon | 1998 |
Mania associated with donepezil.
Topics: Aged; Bipolar Disorder; Dementia; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Middle Aged; Nootropic Agents; Piperidines | 1998 |
[Drug therapy strategies in Alzheimer's disease].
Topics: Aggression; Alzheimer Disease; Anti-Anxiety Agents; Antidepressive Agents; Antipsychotic Agents; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Depression; Donepezil; Humans; Indans; Mental Disorders; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Sleep Wake Disorders; Tacrine | 1998 |
[Alzheimer's disease. Foreword].
Topics: Age Factors; Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 1998 |
Donepezil improves symptoms of delirium in dementia: implications for future research.
Topics: Aged; Alcohol Withdrawal Delirium; Cholinesterase Inhibitors; Cognition Disorders; Delirium; Dementia; Donepezil; Humans; Indans; Male; Mood Disorders; Piperidines; Treatment Outcome | 1998 |
Efficacy of donepezil in Alzheimer's disease: fact or artifact?
Topics: Alzheimer Disease; Artifacts; Clinical Trials as Topic; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Treating Alzheimer's disease with cholinergic drugs, Part 2.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Trichlorfon | 1999 |
Donepezil for dementia with Lewy bodies: a case study.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Hallucinations; Humans; Indans; Parkinson Disease; Piperidines; Treatment Outcome | 1999 |
Comparison between huperzine A, tacrine, and E2020 on cholinergic transmission at mouse neuromuscular junction in vitro.
Topics: Action Potentials; Alkaloids; Animals; Cholinesterase Inhibitors; Donepezil; Female; Indans; Male; Membrane Potentials; Mice; Muscle Fibers, Skeletal; Neuromuscular Junction; Phrenic Nerve; Piperidines; Sesquiterpenes; Tacrine | 1997 |
Donepezil overdose.
Topics: Aged; Cholinesterase Inhibitors; Cognition Disorders; Dementia, Multi-Infarct; Donepezil; Drug Overdose; Female; Humans; Indans; Piperidines; Poison Control Centers | 1999 |
Donepezil for postoperative delirium associated with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Delirium; Donepezil; Geriatric Assessment; Humans; Indans; Male; Nootropic Agents; Piperidines; Postoperative Complications; Time Factors | 1999 |
Convulsions induced by donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Piperidines; Seizures | 1999 |
A comparative study in rats of the in vitro and in vivo pharmacology of the acetylcholinesterase inhibitors tacrine, donepezil and NXX-066.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Carbachol; Cholinesterase Inhibitors; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Indoles; Injections, Intraperitoneal; Isoquinolines; Logistic Models; Male; Physostigmine; Piperidines; Rats; Structure-Activity Relationship; Tacrine; Tumor Cells, Cultured | 1999 |
Disease, drugs, decisions, and dollars.
Topics: Alzheimer Disease; Cost-Benefit Analysis; Decision Making; Donepezil; Health Care Costs; Humans; Indans; Piperidines | 1999 |
Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Costs and Cost Analysis; Disease Progression; Donepezil; Humans; Indans; Piperidines; Quality of Life | 1999 |
Guideline for primary care management of dementia. GPs may want to continue prescribing donepezil for patients.
Topics: Dementia; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Guideline for primary care management of dementia. Some recommendations given are not based directly on evidence cited.
Topics: Data Interpretation, Statistical; Dementia; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Practice Guidelines as Topic | 1999 |
Economic evaluation of donepezil for the treatment of Alzheimer's disease in Canada.
Topics: Aged; Alzheimer Disease; Canada; Cholinesterase Inhibitors; Cost-Benefit Analysis; Decision Support Techniques; Donepezil; Humans; Indans; Markov Chains; Mental Status Schedule; Piperidines | 1999 |
Use of donepezil for vascular dementia: preliminary clinical experience.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Female; Humans; Indans; Male; Piperidines | 1999 |
Structure of acetylcholinesterase complexed with E2020 (Aricept): implications for the design of new anti-Alzheimer drugs.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Indans; Macromolecular Substances; Mice; Models, Molecular; Nootropic Agents; Piperidines; Protein Conformation; Solvents; Structure-Activity Relationship; Substrate Specificity; Torpedo | 1999 |
Anticholinesterase effects of huperzine A, E2020, and tacrine in rats.
Topics: Acetylcholinesterase; Alkaloids; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Tacrine | 1998 |
Mania and donepezil.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Depressive Disorder, Major; Donepezil; Female; Humans; Indans; Male; Piperidines | 1999 |
Treating visual hallucinations with donepezil.
Topics: Age Factors; Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Hallucinations; Humans; Indans; Male; Piperidines; Visual Perception | 1999 |
Brain injury, cognitive impairment, and donepezil.
Topics: Alzheimer Disease; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Simultaneous determination of donepezil (aricept) enantiomers in human plasma by liquid chromatography-electrospray tandem mass spectrometry.
Topics: Calibration; Cholinesterase Inhibitors; Chromatography, Liquid; Donepezil; Humans; Indans; Mass Spectrometry; Piperidines; Reproducibility of Results; Stereoisomerism | 1999 |
Donepezil for Tourette's disorder and ADHD.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Comorbidity; Donepezil; Humans; Indans; Male; Nootropic Agents; Piperidines; Tourette Syndrome | 1999 |
Donepezil and paroxetine: possible drug interaction.
Topics: Aged; Aggression; Akathisia, Drug-Induced; Antidepressive Agents, Second-Generation; Confusion; Diarrhea; Donepezil; Drug Interactions; Female; Flatulence; Humans; Indans; Male; Nootropic Agents; Paroxetine; Piperidines; Sleep Initiation and Maintenance Disorders | 1999 |
Effectiveness of donepezil in treating Alzheimer's disease.
Topics: Alzheimer Disease; Donepezil; Drug Monitoring; Humans; Indans; Interview, Psychological; Mental Status Schedule; Nootropic Agents; Piperidines; Psychometrics | 1999 |
The cost-effectiveness of donepezil therapy in Swedish patients with Alzheimer's disease: a Markov model.
Topics: Aged; Alzheimer Disease; Clinical Trials as Topic; Data Collection; Donepezil; Humans; Indans; Markov Chains; Nootropic Agents; Piperidines; Sensitivity and Specificity; Sweden | 1999 |
Adverse effects of donepezil in treating Alzheimer's disease associated with Down's syndrome.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Comorbidity; Donepezil; Down Syndrome; Female; Humans; Indans; Male; Middle Aged; Piperidines; Urinary Incontinence | 1999 |
Evidence-based psychopharmacology 1. Appraising a single therapeutic trial: what is the evidence for treating early Alzheimer's disease with donepezil?
Topics: Aged; Alzheimer Disease; Donepezil; Evidence-Based Medicine; Humans; Indans; Male; Nootropic Agents; Piperidines; Psychopharmacology; Randomized Controlled Trials as Topic | 1999 |
Effect of donepezil hydrochloride (E2020) on basal concentration of extracellular acetylcholine in the hippocampus of rats.
Topics: Acetylcholine; Acetylcholinesterase; Administration, Oral; Animals; Brain; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Extracellular Space; Hippocampus; Indans; Male; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine | 1999 |
Comments on donepezil open label trial.
Topics: Cognition; Dementia; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
The spectrum of behavioral responses to cholinesterase inhibitor therapy in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Mental Disorders; Neuropsychological Tests; Piperidines; Prognosis; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 1999 |
Prescribing. Short rations.
Topics: Aged; Alzheimer Disease; Donepezil; Drug Utilization; Ethics, Medical; Health Care Rationing; Health Care Surveys; Humans; Indans; Nootropic Agents; Piperidines; United Kingdom | 1999 |
Absorption, distribution, metabolism, and excretion of donepezil (Aricept) after a single oral administration to Rat.
Topics: Administration, Oral; Animals; Bile Ducts; Blood-Brain Barrier; Brain; Carbon Radioisotopes; Catheterization; Cholinesterase Inhibitors; Donepezil; Feces; Indans; Male; Metabolic Clearance Rate; Piperidines; Rats; Rats, Sprague-Dawley; Tissue Distribution | 1999 |
Mania associated with donepezil.
Topics: Aged; Alzheimer Disease; Bipolar Disorder; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Piperidines | 1999 |
Effect of donepezil hydrochloride (E2020) on extracellular acetylcholine concentration in the cerebral cortex of rats.
Topics: Animals; Benzazepines; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Electrochemistry; Extracellular Space; Indans; Male; Microdialysis; Nootropic Agents; Peripheral Nervous System; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine | 1999 |
Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human.
Topics: Administration, Oral; Algorithms; Animals; Biotransformation; Blood Proteins; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Dogs; Donepezil; Female; Humans; In Vitro Techniques; Indans; Injections, Intravenous; Kinetics; Male; Microsomes, Liver; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Species Specificity | 1999 |
[Cholinergic hypothesis and Alzheimer's disease: the place of donepezil (Aricept)].
Topics: Aged; Alzheimer Disease; Choline Deficiency; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Neuropsychological Tests; Piperidines | 1999 |
The cholinergic hypothesis of Alzheimer's disease: a review of progress.
Topics: Alzheimer Disease; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Indans; Piperidines | 1999 |
Inhibitory effects of donepezil hydrochloride (E2020) on cholinesterase activity in brain and peripheral tissues of young and aged rats.
Topics: Aging; Animals; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Erythrocytes; Indans; Male; Peripheral Nervous System; Piperidines; Rats; Rats, Inbred F344; Tacrine | 1999 |
Synthesis and acetylcholinesterase inhibitory activity of huperzine A-E2020 combined compound.
Topics: Alkaloids; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Hippocampus; In Vitro Techniques; Indans; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Sesquiterpenes | 1999 |
New drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Carbamates; Donepezil; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Rivastigmine; Tacrine | 1999 |
Calculation of the natural history line in the long-term extension trial and the use of the 'intent-to-treat' (ITT) principle in donepezil treatment.
Topics: Alzheimer Disease; Bias; Disease Progression; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Sustained cognitive improvement following treatment of Alzheimer's disease with donepezil.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Antidepressive Agents; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Therapy, Combination; Follow-Up Studies; Humans; Indans; Medical Audit; Mental Status Schedule; Middle Aged; Nootropic Agents; Patient Selection; Piperidines; Referral and Consultation; Severity of Illness Index; Treatment Outcome | 2000 |
Donepezil use in managed Medicare: effect on health care costs and utilization.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Prescriptions; Drug Utilization; Female; Health Care Costs; Humans; Indans; Male; Managed Care Programs; Nootropic Agents; Piperidines | 1999 |
Active-site gorge and buried water molecules in crystal structures of acetylcholinesterase from Torpedo californica.
Topics: Acetylcholinesterase; Alkaloids; Amino Acid Sequence; Animals; Binding Sites; Cholinesterase Inhibitors; Crystallization; Crystallography, X-Ray; Donepezil; Edrophonium; Hydrogen Bonding; Indans; Ligands; Models, Molecular; Molecular Sequence Data; Piperidines; Protein Structure, Secondary; Reproducibility of Results; Sesquiterpenes; Static Electricity; Torpedo; Water | 2000 |
Inhibitory effect of orally administered donepezil hydrochloride (E2020), a novel treatment for Alzheimer's disease, on cholinesterase activity in rats.
Topics: Administration, Oral; Alzheimer Disease; Animals; Benzazepines; Brain; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning; Male; Memory; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine | 2000 |
Update on Alzheimer's disease: recent findings and treatments.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Risk Factors; Tacrine | 2000 |
Combination of donepezil and gabapentin for behavioral disorders in Alzheimer's disease.
Topics: Acetates; Aged; Aged, 80 and over; Alzheimer Disease; Amines; Anticonvulsants; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Donepezil; Drug Therapy, Combination; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Male; Mental Disorders; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2000 |
Age-related impairment of coupling mechanism between neuronal activation and functional cerebral blood flow response was restored by cholinesterase inhibition: PET study with microdialysis in the awake monkey brain.
Topics: Acetylcholine; Age Factors; Animals; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Extracellular Space; Glucose; Indans; Macaca mulatta; Male; Microdialysis; Neurons; Physostigmine; Piperidines; Tacrine; Tomography, Emission-Computed; Wakefulness | 2000 |
Donepezil for the treatment of psychosis in dementia with Lewy bodies.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Lewy Body Disease; Male; Piperidines; Psychotic Disorders | 2000 |
No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Memantine; Piperidines; Rats; Rats, Inbred F344; Tacrine | 2000 |
Organophosphate poisoning versus brainstem stroke.
Topics: Aged; Brain Stem Infarctions; Cholinesterase Inhibitors; Diagnosis, Differential; Donepezil; Drug Overdose; Humans; Indans; Insecticides; Male; Nootropic Agents; Organophosphorus Compounds; Piperidines | 2000 |
Practice guidelines for the diagnosis and treatment of Alzheimer's disease in a managed care setting: Part II--Pharmacologic therapy. Alzheimer's Disease (AD) Managed Care Advisory Council.
Topics: Algorithms; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Caregivers; Cholinesterase Inhibitors; Clinical Trials as Topic; Cost-Benefit Analysis; Donepezil; Drug Interactions; Estrogens; Female; Ginkgo biloba; Humans; Indans; Male; Managed Care Programs; Nootropic Agents; Patient Selection; Phytotherapy; Piperidines; Plants, Medicinal; Psychotropic Drugs; Quality of Health Care; Selegiline; Tacrine; Time Factors; Vitamin E | 2000 |
Donepezil for behavioural disorders associated with Lewy bodies: a case series.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Lewy Body Disease; Male; Nootropic Agents; Piperidines; Social Behavior Disorders; Survival Analysis; Treatment Outcome | 2000 |
Prescribing donepezil in clinical practice.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 1999 |
Use of donepezil in elderly patients with Alzheimer's disease--a Hawaii based study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Cholinesterase Inhibitors; Donepezil; Female; Hawaii; Humans; Indans; Male; Piperidines; Retrospective Studies | 2000 |
The relationship between donepezil and behavioral disturbances in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cost of Illness; Donepezil; Humans; Indans; Mental Disorders; Neuropsychological Tests; Nootropic Agents; Personality Assessment; Piperidines | 2000 |
Primary vs subspecialty care: a structured follow-up of dementia patients and their caregivers.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cohort Studies; Consumer Behavior; Donepezil; Female; Follow-Up Studies; Geriatric Psychiatry; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Patient Care Team; Pilot Projects; Piperidines; Primary Health Care; Specialization; Treatment Outcome | 2000 |
Drug interactions and donepezil.
Topics: Antidepressive Agents, Second-Generation; Antifungal Agents; Cholinesterase Inhibitors; Cimetidine; Cytochrome P-450 Enzyme Inhibitors; Donepezil; Drug Interactions; Enzyme Inhibitors; Humans; Indans; Ketoconazole; Paroxetine; Piperidines | 2000 |
Excitatory and inhibitory effects of second-generation cholinesterase inhibitors on rat gastrointestinal transit.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Gastrointestinal Transit; Hydrocarbons, Brominated; Indans; Male; Physostigmine; Piperidines; Pirenzepine; Rats; Rats, Wistar; Receptor, Muscarinic M1; Receptors, Muscarinic; Receptors, Nicotinic; Scopolamine; Tacrine | 2000 |
Changes in pupil reaction to light in Alzheimer's disease patients: a preliminary report.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Light; Piperidines; Pupil; Reaction Time; Reference Values | 2000 |
[Myocardial ischemia in a female patient treated with donepezil].
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Myocardial Ischemia; Piperidines | 2000 |
Donepezil, a centrally acting acetylcholinesterase inhibitor, alleviates learning deficits in hypocholinergic models in rats.
Topics: Animals; Avoidance Learning; Basal Nucleus of Meynert; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Learning Disabilities; Male; Maze Learning; Piperidines; Rats; Rats, Wistar; Scopolamine; Tacrine | 2000 |
[Extra-pyramidal syndrome induced by donepezil].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Basal Ganglia Diseases; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines | 2000 |
Relation between cholinesterase inhibitor and Pisa syndrome.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Dopamine Antagonists; Dystonia; Female; Humans; Indans; Memory Disorders; Middle Aged; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Posture; Psychomotor Agitation; Risperidone; Rivastigmine; Syndrome | 2000 |
Charles Bonnet syndrome and dementia.
Topics: Aged; Diagnosis, Differential; Donepezil; Female; Hallucinations; Humans; Indans; Lewy Body Disease; Nootropic Agents; Piperidines; Syndrome; Vision Disorders | 2000 |
Chronic treatment of old rats with donepezil or galantamine: effects on memory, hippocampal plasticity and nicotinic receptors.
Topics: Acetylcholinesterase; Age Factors; Animals; Cholinesterase Inhibitors; Donepezil; Excitatory Postsynaptic Potentials; Galantamine; Hippocampus; Indans; Male; Memory; Piperidines; Prefrontal Cortex; Rats; Rats, Inbred F344; Receptors, Nicotinic | 2000 |
Urinary incontinence: an unrecognised adverse effect with donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Urinary Incontinence | 2000 |
Limited donepezil inhibition of acetylcholinesterase measured with positron emission tomography in living Alzheimer cerebral cortex.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Middle Aged; Physostigmine; Piperidines; Tomography, Emission-Computed | 2000 |
Donepezil in the treatment of cognitive dysfunction associated with traumatic brain injury.
Topics: Adult; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; Indans; Intelligence; Male; Middle Aged; Piperidines; Retrospective Studies; Treatment Outcome | 2000 |
Donepezil in the treatment of Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Quality of Life | 2000 |
Treatment of REM sleep behavior disorder with donepezil: a report of three cases.
Topics: Adult; Aged; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Middle Aged; Piperidines; Polysomnography; REM Sleep Behavior Disorder | 2000 |
[Delaying Alzheimer dementia. Patient and family relieved--costs lowered].
Topics: Aged; Alzheimer Disease; Cost of Illness; Cost Savings; Donepezil; Germany; Humans; Indans; National Health Programs; Nootropic Agents; Piperidines | 2000 |
Cost-effectiveness of functional imaging tests in the diagnosis of Alzheimer disease.
Topics: Alzheimer Disease; Contrast Media; Cost-Benefit Analysis; Decision Trees; Donepezil; Health Care Costs; Humans; Indans; Magnetic Resonance Imaging; Markov Chains; Models, Economic; Nootropic Agents; Piperidines; Quality-Adjusted Life Years; Sensitivity and Specificity; Tomography, Emission-Computed, Single-Photon | 2000 |
Parkinsonism onset in a patient concurrently using tiapride and donepezil.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Dopamine Antagonists; Drug Therapy, Combination; Female; Humans; Indans; Parkinsonian Disorders; Piperidines; Tiapamil Hydrochloride | 2000 |
Use of donepezil for the treatment of mild-moderate Alzheimer's disease: an audit of the assessment and treatment of patients in routine clinical practice.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Drug Utilization; Drug Utilization Review; Family Practice; Female; Guideline Adherence; Humans; Indans; Male; Medical Records; Middle Aged; Nootropic Agents; Piperidines; Practice Patterns, Physicians'; Prognosis; Psychiatric Status Rating Scales; Retrospective Studies; Severity of Illness Index; Treatment Outcome; United Kingdom | 2000 |
Adjunctive donepezil in attention deficit hyperactivity disorder youth: case series.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Piperidines | 2000 |
Donepezil dose-dependently inhibits acetylcholinesterase activity in various areas and in the presynaptic cholinergic and the postsynaptic cholinoceptive enzyme-positive structures in the human and rat brain.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Blood Vessels; Brain; Cerebral Cortex; Cholinergic Fibers; Dendrites; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Humans; Indans; Middle Aged; Neostriatum; Neuromuscular Junction; Piperidines; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Synapses | 2000 |
The new cholinesterase inhibitors for Alzheimer's disease, Part 1: their similarities are different.
Topics: Aged; Alzheimer Disease; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, Nicotinic; Rivastigmine; Tacrine | 2000 |
Impact of donepezil on caregiving burden for patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cost of Illness; Donepezil; Female; Humans; Indans; Male; Piperidines | 2000 |
Abnormal movements with donepezil in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Movement Disorders; Piperidines | 2000 |
The new cholinesterase inhibitors for Alzheimer's disease, Part 2: illustrating their mechanisms of action.
Topics: Alzheimer Disease; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Receptors, Nicotinic; Rivastigmine | 2000 |
Comparison of donepezil-, tacrine-, rivastigmine- and metrifonate-induced central and peripheral cholinergically mediated responses in the rat.
Topics: Animals; Body Temperature; Carbamates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Hypothermia; Indans; Lacrimal Apparatus; Male; Phenylcarbamates; Piperidines; Rats; Rivastigmine; Saliva; Tacrine; Tremor; Trichlorfon | 2000 |
Hypnopompic hallucinations with donepezil.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cognition Disorders; Diagnosis, Differential; Donepezil; Electroencephalography; Hallucinations; Humans; Indans; Insecta; Male; Middle Aged; Personality; Piperidines; Sleep, REM | 2000 |
Fulminant chemical hepatitis possibly associated with donepezil and sertraline therapy.
Topics: Aged; Aged, 80 and over; Alkaline Phosphatase; Alzheimer Disease; Bilirubin; Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Donepezil; Drug Monitoring; Drug Therapy, Combination; Female; gamma-Glutamyltransferase; Humans; Indans; Liver Failure, Acute; Liver Function Tests; Nootropic Agents; Piperidines; Selective Serotonin Reuptake Inhibitors; Sertraline; Tomography, X-Ray Computed | 2000 |
Donepezil for Down's syndrome.
Topics: Adult; Age Factors; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Comorbidity; Donepezil; Dose-Response Relationship, Drug; Down Syndrome; Drug Administration Schedule; Humans; Indans; Middle Aged; Piperidines; Treatment Outcome | 2001 |
Synthesis and biological evaluation of 1-(4-[18F]fluorobenzyl)-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl]piperidine for in vivo studies of acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Brain; Donepezil; Fluorine Radioisotopes; Indans; Male; Mice; Mice, Inbred ICR; Piperidines; Radionuclide Imaging; Radiopharmaceuticals; Tissue Distribution | 2000 |
Pharmacological evaluation of [11C]donepezil as a tracer for visualization of acetylcholinesterase by PET.
Topics: Acetylcholinesterase; Animals; Binding, Competitive; Brain; Carbon Radioisotopes; Cholinesterase Inhibitors; Donepezil; Female; Indans; Isotope Labeling; Male; Mice; Piperidines; Rabbits; Radiopharmaceuticals; Tissue Distribution; Tomography, Emission-Computed | 2000 |
Effect of donepezil on brain acetylcholinesterase activity in patients with AD measured by PET.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Brain; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Time Factors; Tomography, Emission-Computed | 2001 |
Improvement in sundowning in dementia with Lewy bodies after treatment with donepezil.
Topics: Aged; Cholinesterase Inhibitors; Circadian Rhythm; Donepezil; Humans; Indans; Lewy Body Disease; Male; Piperidines; Psychomotor Agitation; Treatment Outcome | 2000 |
Carers' assessment of patients on donepezil--how reliable?
Topics: Aged; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Reproducibility of Results; Treatment Outcome | 2000 |
Donepezil and Alzheimer's dementia.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Costs; Evidence-Based Medicine; Humans; Indans; Piperidines | 2000 |
[Treatment of the elderly dementia patients].
Topics: Aged; Alzheimer Disease; Benzazepines; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Piperidines; Tacrine; Trichlorfon | 2000 |
Drugs for dementia: the first year. An audit of prescribing practice.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Drug Prescriptions; Drug Utilization; Follow-Up Studies; Guideline Adherence; Humans; Indans; Medical Audit; Piperidines; Practice Patterns, Physicians' | 2000 |
Adverse effects associated with the use of donepezil in general practice in England.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Drug Prescriptions; England; Female; Follow-Up Studies; Humans; Indans; Male; Nausea; Nootropic Agents; Piperidines; Product Surveillance, Postmarketing; Vomiting | 2000 |
Successful use of donepezil for the treatment of dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Lewy Body Disease; Nootropic Agents; Piperidines | 2001 |
Donepezil-induced REM sleep augmentation enhances memory performance in elderly, healthy persons.
Topics: Aged; Aging; Animals; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Learning; Male; Memory; Middle Aged; Nootropic Agents; Piperidines; Sleep, REM | 2001 |
Treatment of tardive dyskinesia with donepezil.
Topics: Adult; Aged; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Dyskinesia, Drug-Induced; Humans; Indans; Male; Middle Aged; Piperidines; Psychotic Disorders; Schizophrenia; Treatment Outcome | 2001 |
[Early recognition not hopeless. Alzheimer disease can be delayed].
Topics: Aged; Alzheimer Disease; Donepezil; Humans; Indans; Mental Status Schedule; Nootropic Agents; Piperidines; Treatment Outcome | 2001 |
Analysis and enantioresolution of donepezil by capillary electrophoresis.
Topics: Cholinesterase Inhibitors; Donepezil; Electrophoresis, Capillary; Indans; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2001 |
Comparison of inhibitory activities of donepezil and other cholinesterase inhibitors on acetylcholinesterase and butyrylcholinesterase in vitro.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminoquinolines; Animals; Benzazepines; Brain; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Inhibitory Concentration 50; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rivastigmine; Tacrine; Time Factors | 2000 |
Central and peripheral activity of cholinesterase inhibitors as revealed by yawning and fasciculation in rats.
Topics: Acetylcholinesterase; Animals; Benzazepines; Benzoxazines; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Fasciculation; Indans; Male; Muscarinic Antagonists; Oxazines; Piperidines; Rats; Rats, Wistar; Tacrine; Yawning | 2001 |
Anticholinesterase drugs for alcoholic Korsakoff syndrome.
Topics: Cholinesterase Inhibitors; Donepezil; Humans; Indans; Korsakoff Syndrome; Male; Middle Aged; Piperidines | 2001 |
Bayesian value-of-information analysis. An application to a policy model of Alzheimer's disease.
Topics: Alzheimer Disease; Bayes Theorem; Cost-Benefit Analysis; Decision Theory; Disease Progression; Donepezil; Humans; Indans; Information Storage and Retrieval; Nootropic Agents; Piperidines; Policy Making; Technology Assessment, Biomedical; Treatment Outcome; United States; Value of Life | 2001 |
Donepezil in the treatment of opioid-induced sedation: report of six cases.
Topics: Adult; Aged; Analgesics, Opioid; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Pain; Piperidines; Sleep Stages | 2001 |
Structure-based 3D QSAR and design of novel acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Binding Sites; Cholinesterase Inhibitors; Computer Simulation; Crystallography, X-Ray; Donepezil; Drug Design; Humans; Indans; Models, Molecular; Piperidines; Protein Conformation; Quantitative Structure-Activity Relationship; Thermodynamics; Torpedo | 2001 |
Pharmacokinetic profiles of current therapies for Alzheimer's disease: implications for switching to galantamine.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Sleep | 2001 |
Effects of washout and dose-escalation periods on the efficacy, safety, and tolerability of galantamine in patients previously treated with donepezil: ongoing clinical trials.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Administration Schedule; Galantamine; Humans; Indans; Piperidines | 2001 |
Pharmacokinetic rationale for switching from donepezil to galantamine.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Models, Biological; Piperidines | 2001 |
Huperzine A and donepezil protect rat pheochromocytoma cells against oxygen-glucose deprivation.
Topics: Alkaloids; Alzheimer Disease; Animals; Cell Size; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Glucose; Hypoxia-Ischemia, Brain; Indans; Lipid Peroxidation; Malondialdehyde; Neuroprotective Agents; Oxidative Stress; PC12 Cells; Piperidines; Rats; Sesquiterpenes; Superoxide Dismutase; Tetrazolium Salts; Thiazoles | 2001 |
Equity in the new NHS: hard lessons from implementing a local healthcare policy on donepezil.
Topics: Aged; Alzheimer Disease; Donepezil; Drug Costs; Health Services Accessibility; Humans; Indans; Nootropic Agents; Piperidines; Social Justice; State Medicine | 2001 |
[Aphasia and dementia].
Topics: Aged; Aphasia, Primary Progressive; Atrophy; Brain; Dementia; Diagnosis, Differential; Donepezil; Female; Humans; Indans; Nootropic Agents; Piperidines; Radionuclide Imaging; Temporal Lobe; Treatment Outcome | 2001 |
Pisa syndrome due to a cholinesterase inhibitor (donepezil): a case report.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dystonia; Humans; Indans; Male; Middle Aged; Piperidines; Psychomotor Disorders | 2001 |
Medications for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Donepezil; Estrogen Replacement Therapy; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2001 |
Featured CME topic: dementia. Medication update.
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Contraindications; Donepezil; Drug Interactions; Ergoloid Mesylates; Galantamine; Ginkgo biloba; Humans; Indans; Nootropic Agents; Phenylcarbamates; Phytotherapy; Piperidines; Plants, Medicinal; Rivastigmine | 2001 |
Cerebrospinal fluid acetylcholinesterase activity after long-term treatment with donepezil and rivastigmina.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Butyrylcholinesterase; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Protein Isoforms; Rivastigmine; Time Factors | 2001 |
Maintaining functional and behavioral abilities in Alzheimer disease.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine; Treatment Outcome | 2001 |
A new HPLC method to determine Donepezil hydrochloride in tablets.
Topics: Chromatography, High Pressure Liquid; Donepezil; Drug Stability; Indans; Piperidines; Reproducibility of Results; Tablets | 2002 |
Synthesis and screening for antiacetylcholinesterase activity of (1-benzyl-4-oxopiperidin-3-ylidene)methylindoles and -pyrroles related to donepezil.
Topics: Acetylcholinesterase; Donepezil; Drug Evaluation, Preclinical; Indans; Indoles; Luminescent Measurements; Models, Molecular; Nootropic Agents; Piperidines; Pyrroles; Structure-Activity Relationship | 2001 |
[Relief for caregivers. Anti-dementia drug saves costs].
Topics: Aged; Alzheimer Disease; Caregivers; Cost Control; Cost of Illness; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2001 |
Equity in the new NHS. Evidence cannot help in all situations.
Topics: Donepezil; Evidence-Based Medicine; Health Care Rationing; Humans; Indans; Nootropic Agents; Piperidines; United Kingdom | 2001 |
EEG changes during long-term treatment with donepezil in Alzheimer's disease patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Humans; Indans; Male; Middle Aged; Pilot Projects; Piperidines | 2001 |
Economic evaluation of donepezil treatment for Alzheimer's disease in Japan.
Topics: Alzheimer Disease; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Donepezil; Drug Costs; Fee Schedules; Health Policy; Humans; Indans; Japan; Markov Chains; Nootropic Agents; Piperidines; Quality of Life; Quality-Adjusted Life Years; Severity of Illness Index | 2002 |
[Effectiveness of donepezil on several cognitive functions in patients with Alzheimer's disease over 12 months].
Topics: Acetylcholine; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Female; Humans; Indans; Male; Memory; Neuropsychological Tests; Piperidines; Verbal Behavior | 2001 |
[Malignant syndrome caused by a combination of bromperidol and donepezil hydrochloride in a patient with probable dementia with Lewy bodies].
Topics: Aged; Donepezil; Drug Therapy, Combination; Hallucinations; Haloperidol; Humans; Indans; Lewy Body Disease; Male; Neuroleptic Malignant Syndrome; Nootropic Agents; Piperidines | 2001 |
Donepezil in schizophrenia--is it helpful? An experimental design case study.
Topics: Adult; Antipsychotic Agents; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Therapy, Combination; Humans; Indans; Male; Piperidines; Risperidone; Schizophrenia; Treatment Outcome | 2001 |
[A patient with probable dementia with Lewy bodies, who showed improvement of dementia and parkinsonism by the administratim of donepezil].
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Humans; Indans; Lewy Body Disease; Male; Parkinson Disease; Piperidines | 2001 |
Feasibility of vascular dementia treatment with cholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Feasibility Studies; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines | 2002 |
Unsafe prescription medication switching recommendations.
Topics: Alzheimer Disease; Donepezil; Drug Interactions; Galantamine; Humans; Indans; Nootropic Agents; Piperidines | 2001 |
Treatment of tardive dyskinesia with donepezil: a pilot study.
Topics: Adult; Aged; Antipsychotic Agents; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Dyskinesia, Drug-Induced; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Neurologic Examination; Pilot Projects; Piperidines; Psychiatric Status Rating Scales; Psychotic Disorders; Schizophrenia | 2001 |
Donepezil in the treatment of Alzheimer's disease: long-term efficacy and safety.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Donepezil; Female; Gastrointestinal Diseases; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Treatment Outcome | 2002 |
[Alzheimer dementia. Comparison of the effectiveness of cholinesterase inhibitors and gingko].
Topics: Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Confidence Intervals; Donepezil; Galantamine; Ginkgo biloba; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Parasympathomimetics; Phenylcarbamates; Phytotherapy; Piperidines; Placebos; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Rivastigmine | 2001 |
[Alzheimer dementia. Intervening as early as possible].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Prognosis | 2002 |
Ameliorative effects of azaindolizinone derivative ZSET845 on scopolamine-induced deficits in passive avoidance and radial-arm maze learning in the rat.
Topics: Alzheimer Disease; Animals; Avoidance Learning; Choline O-Acetyltransferase; Cognition; Donepezil; Dose-Response Relationship, Drug; Enzyme Induction; Hippocampus; Indans; Male; Maze Learning; Piperidines; Pyridones; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2001 |
Determination of donepezil, an acetylcholinesterase inhibitor, in human plasma by high-performance liquid chromatography with ultraviolet absorbance detection.
Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Piperidines; Reference Standards; Reproducibility of Results; Spectrophotometry, Ultraviolet | 2002 |
A 1-year, randomized, placebo-controlled study of donepezil in patients with mild to moderate AD.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Comorbidity; Donepezil; Humans; Indans; Piperidines; Placebos; Randomized Controlled Trials as Topic | 2002 |
Donepezil management of schizophrenia with associated dementia.
Topics: Aged; Antiparkinson Agents; Antipsychotic Agents; Comorbidity; Dementia; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Mental Status Schedule; Middle Aged; Nootropic Agents; Parkinson Disease; Piperidines; Psychiatric Status Rating Scales; Risperidone; Schizophrenia | 2002 |
Switching cholinesterase inhibitor therapy in Alzheimer's disease--donepezil to rivastigmine, is it worth it?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Treatment Outcome; United Kingdom | 2002 |
The effects of an orally administered cholinergic agonist on REM sleep in major depression.
Topics: Administration, Oral; Adult; Cholinergic Agents; Cholinesterase Inhibitors; Depressive Disorder, Major; Donepezil; Female; Humans; Indans; Male; Middle Aged; Piperidines; Polysomnography; Reaction Time; Single-Blind Method; Sleep, REM | 2002 |
The effect of donepezil therapy on health costs in a Medicare managed care plan.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Case-Control Studies; Cost of Illness; Cost-Benefit Analysis; Donepezil; Female; Health Care Costs; Health Expenditures; Humans; Indans; Male; Managed Care Programs; Medicare; Nootropic Agents; Piperidines; United States | 2002 |
Delirium caused by donepezil: a case study.
Topics: Aged; Alzheimer Disease; Atrophy; Cerebral Cortex; Delirium; Donepezil; Humans; Indans; Male; Nootropic Agents; Piperidines | 2002 |
Effects of T-82, a new quinoline derivative, on cholinesterase activity and extracellular acetylcholine concentration in rat brain.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Cholinesterases; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Humans; Indans; Male; Phenothiazines; Piperidines; Quinolines; Rats; Rats, Wistar; Salivation; Tacrine; Temperature | 2002 |
Reversal of scopolamine-induced spatial memory deficits in rats by TAK-147.
Topics: Animals; Benzazepines; Cholinesterase Inhibitors; Donepezil; Indans; Male; Maze Learning; Memory Disorders; Motor Activity; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine; Tacrine | 2002 |
Randomized, placebo-controlled, parallel group versus crossover study designs for the study of dementia in Parkinson's disease.
Topics: Bias; Cognition; Cross-Over Studies; Dementia; Donepezil; Effect Modifier, Epidemiologic; Humans; Indans; Nootropic Agents; Parkinson Disease; Piperidines; Randomized Controlled Trials as Topic; Research Design; Sample Size | 2002 |
A rapid method for pKa determination of drugs using pressure-assisted capillary electrophoresis with photodiode array detection in drug discovery.
Topics: Donepezil; Drug Design; Electrophoresis, Capillary; Hydrogen-Ion Concentration; Indans; Piperidines; Pressure; Technology, Pharmaceutical | 2002 |
Pharmacological treatment of cognitive deficits in Alzheimer's disease.
Topics: Alzheimer Disease; Diarrhea; Donepezil; Humans; Indans; Nausea; Nootropic Agents; Piperidines; Vomiting | 2002 |
Evaluation of cholinergic treatment in demented patients by P300 evoked related potentials.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Carbamates; Cholinesterase Inhibitors; Cognition; Donepezil; Evaluation Studies as Topic; Event-Related Potentials, P300; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Piperidines; Reaction Time; Rivastigmine; Sensitivity and Specificity; Severity of Illness Index; Tacrine | 2001 |
ApoE genotype influences the biological effect of donepezil on APP metabolism in Alzheimer disease: evidence from a peripheral model.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Analysis of Variance; Apolipoproteins E; Blood Platelets; Cholinesterase Inhibitors; Donepezil; Female; Genotype; Humans; Indans; Longitudinal Studies; Male; Nootropic Agents; Piperidines; Regression Analysis | 2002 |
Use of anticholinergic medications by older adults with dementia.
Topics: Age Factors; Aged; Aged, 80 and over; Case-Control Studies; Cholinergic Antagonists; Cholinesterase Inhibitors; Contraindications; Dementia; Donepezil; Female; Humans; Indans; Male; Piperidines; Retrospective Studies | 2002 |
Effects of donepezil (Aricept) on the rapid eye movement sleep of normal subjects.
Topics: Adult; Cholinesterase Inhibitors; Cross-Over Studies; Donepezil; Double-Blind Method; Humans; Indans; Male; Piperidines; Polysomnography; Sleep, REM | 2002 |
New acetylcholinesterase inhibitor (donepezil) treatment for Alzheimer's disease in a chronic dialysis patient.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Kidney Failure, Chronic; Male; Piperidines; Renal Dialysis | 2002 |
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia.
Topics: Alzheimer Disease; Animals; Brain Infarction; Brain Ischemia; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Male; Memory Disorders; Muscarinic Antagonists; Perforant Pathway; Piperidines; Rats; Rats, Wistar; Reaction Time; Reperfusion Injury; Scopolamine | 2002 |
Extrapyramidal side-effect due to drug combination of risperidone and donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Basal Ganglia Diseases; Donepezil; Drug Interactions; Drug Therapy, Combination; Female; Humans; Indans; Nootropic Agents; Piperidines; Risperidone | 2002 |
Effect of subchronic administration of metrifonate, rivastigmine and donepezil on brain acetylcholine in aged F344 rats.
Topics: Acetylcholine; Aging; Animals; Body Weight; Brain; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Administration Schedule; Hippocampus; Indans; Male; Muscarinic Antagonists; Phenylcarbamates; Piperidines; Pirenzepine; Rats; Rats, Inbred F344; Rivastigmine; Trichlorfon | 2002 |
PET imaging of brain acetylcholinesterase using [11C]CP-126,998, a brain selective enzyme inhibitor.
Topics: Acetylcholinesterase; Adult; Animals; Brain; Carbon Radioisotopes; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Radiation; Humans; Indans; Isoxazoles; Kinetics; Male; Mice; Piperidines; Tissue Distribution; Tomography, Emission-Computed | 2002 |
Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Donepezil; Eponyms; Female; Germany; History, 19th Century; History, 20th Century; Humans; Indans; Male; Nootropic Agents; Piperidines; Receptor for Advanced Glycation End Products; Receptors, Immunologic | 2002 |
Combination of a novel antidementia drug FK960 with donepezil synergistically improves memory deficits in rats.
Topics: Aging; Animals; Avoidance Learning; Basal Nucleus of Meynert; Benzamides; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Electroshock; Indans; Male; Memory Disorders; Nootropic Agents; Piperazines; Piperidines; Rats; Rats, Wistar; Scopolamine | 2002 |
Brain perfusion follow-up in Alzheimer's patients during treatment with acetylcholinesterase inhibitors.
Topics: Aged; Alzheimer Disease; Brain; Carbamates; Case-Control Studies; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Phenylcarbamates; Piperidines; Radiopharmaceuticals; Rivastigmine; Technetium Tc 99m Exametazime; Time Factors; Tomography, Emission-Computed, Single-Photon | 2002 |
Quaternary salts of E2020 analogues as acetylcholinesterase inhibitors for the reversal of neuromuscular block.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Indans; Neuromuscular Nondepolarizing Agents; Piperidines; Vecuronium Bromide | 2002 |
[The efficacy of donepezil in Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines | 2002 |
Quantitative EEG changes in Alzheimer patients during long-term donepezil therapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Humans; Indans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales | 2002 |
Donepezil for memory dysfunction in schizophrenia.
Topics: Antipsychotic Agents; Chronic Disease; Dibenzothiazepines; Donepezil; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Indans; Mental Recall; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Quetiapine Fumarate; Retention, Psychology; Schizophrenia; Schizophrenic Psychology | 2002 |
Comparison of functional and cognitive donepezil effects in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Piperidines | 2002 |
Fatal aspiration pneumonia during transition from donepezil to rivastigmine.
Topics: Aged; Aged, 80 and over; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Fatal Outcome; Humans; Indans; Male; Phenylcarbamates; Piperidines; Pneumonia, Aspiration; Rivastigmine | 2002 |
The impact of journal advertisements on prescribers of cholinesterase inhibitors.
Topics: Advertising; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Drug Prescriptions; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Publishing; Random Allocation; Rivastigmine | 2002 |
Do you know about donepezil and succinylcholine?
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Drug Information Services; Drug Synergism; Humans; Indans; Neuromuscular Depolarizing Agents; Piperidines; Succinylcholine | 2002 |
Effect of 3-[1-(phenylmethyl)-4-piperidinyl]-1-(2,3,4,5-tetrahydro-1H-1-benzazepin-8-yl)-1-propanone fumarate, a novel acetylcholinesterase inhibitor, on spatial cognitive impairment induced by chronic cerebral hypoperfusion in rats.
Topics: Animals; Benzazepines; Brain; Brain Ischemia; Cholinesterase Inhibitors; Coloring Agents; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Neuroprotective Agents; Organ Culture Techniques; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine; Tetrazolium Salts | 2002 |
Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.
Topics: Animals; Benzopyrans; Cholinesterase Inhibitors; Donepezil; Female; Indans; Memory; Nicotinic Agonists; Ovariectomy; Piperidines; Proline; Rats; Rats, Sprague-Dawley; Space Perception; Stimulation, Chemical; Visual Perception | 2002 |
[Acetylcholinesterase inhibitor. Helpful not just in Alzheimer dementia].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Parkinson Disease; Piperidines; Randomized Controlled Trials as Topic | 2002 |
Use of artificial networks in clinical trials: a pilot study to predict responsiveness to donepezil in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Discriminant Analysis; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Middle Aged; Neural Networks, Computer; Pilot Projects; Piperidines; Predictive Value of Tests; Reproducibility of Results; Severity of Illness Index | 2002 |
Donepezil for cognitive deficits following traumatic brain injury: a case report.
Topics: Adult; Brain Injuries; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Male; Neuropsychological Tests; Piperidines | 2002 |
A case series of D-cycloserine added to donepezil in the treatment of Alzheimer's disease.
Topics: Adolescent; Adult; Alzheimer Disease; Antimetabolites; Child; Cholinesterase Inhibitors; Cognition Disorders; Cycloserine; Donepezil; Drug Therapy, Combination; Humans; Indans; Neuropsychological Tests; Piperidines | 2002 |
A retrospective open trial of adjunctive donepezil in children and adolescents with autistic disorder.
Topics: Adolescent; Adult; Autistic Disorder; Child; Donepezil; Female; Humans; Indans; Male; Pilot Projects; Piperidines; Retrospective Studies | 2002 |
Comments on Efficacy and safety of rivastigmine in patients with Alzheimer's disease who failed to benefit from treatment with donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Carbamates; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Reproducibility of Results; Research Design; Rivastigmine | 2002 |
Effects of huperzine A on acetylcholinesterase isoforms in vitro: comparison with tacrine, donepezil, rivastigmine and physostigmine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Hippocampus; Indans; Isoenzymes; Kinetics; Male; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Tacrine | 2002 |
[Many Alzheimer patients untreated].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Germany; Humans; Indans; Piperidines; Treatment Outcome | 2002 |
FK960, a potential anti-dementia drug, increases synaptic density in the hippocampal CA3 region of aged rats.
Topics: Aging; Animals; Benzamides; Cell Count; Donepezil; Hippocampus; Indans; Male; Nootropic Agents; Piperazines; Piperidines; Rats; Rats, Inbred F344; Synapses | 2002 |
Responses to donepezil in Alzheimer's disease and Parkinson's disease.
Topics: Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Parkinson Disease; Piperidines; Tomography, Emission-Computed, Single-Photon | 2002 |
Assessing the efficacy of cholinesterase inhibitor drugs.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Treatment Failure; Treatment Outcome | 2003 |
Donepezil for nursing home patients with dementia: a reinterpretation of the evidence.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Mental Status Schedule; Nursing Homes; Piperidines | 2003 |
Getting donepezil into the nursing home.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Mental Status Schedule; Nursing Homes; Piperidines | 2003 |
Suxamethonium and donepezil: a cause of prolonged paralysis.
Topics: Aged; Anesthesia, General; Donepezil; Drug Interactions; Female; Fractures, Bone; Humans; Indans; Neuromuscular Depolarizing Agents; Nootropic Agents; Paralysis; Piperidines; Succinylcholine; Wrist Injuries | 2003 |
Donepezil and succinylcholine.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Humans; Indans; Neuromuscular Depolarizing Agents; Piperidines; Succinylcholine | 2003 |
Acetylcholinesterase inhibitors for vascular dementia and Alzheimer's disease combined with cerebrovascular disease.
Topics: Alzheimer Disease; Cerebrovascular Disorders; Cholinesterase Inhibitors; Cognition Disorders; Dementia, Vascular; Diagnosis, Differential; Donepezil; Galantamine; Humans; Indans; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Terminology as Topic; Treatment Outcome | 2003 |
[Effects of donepezil on the delayed rectifier-like potassium current in pyramidal neurons of rat hippocampus and neocortex].
Topics: Animals; Cholinesterase Inhibitors; Delayed Rectifier Potassium Channels; Donepezil; Hippocampus; In Vitro Techniques; Indans; Male; Neocortex; Neurons; Patch-Clamp Techniques; Piperidines; Potassium Channels; Potassium Channels, Voltage-Gated; Pyramidal Cells; Rats; Rats, Wistar | 2002 |
[Protective effects of tacrine and donepezil against staurosporine-induced apoptotic death].
Topics: Animals; Apoptosis; Cholinesterase Inhibitors; Donepezil; Glioma; HeLa Cells; Humans; Hybrid Cells; Indans; Mice; Neuroblastoma; Piperidines; Protective Agents; Rats; Staurosporine; Tacrine | 2002 |
Donepezil use in the treatment of dementia associated with Down syndrome.
Topics: Adult; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia; Donepezil; Down Syndrome; Female; Humans; Indans; Male; Middle Aged; Piperidines; Research Design; Sample Size | 2003 |
Tolerability of memantine in combination with cholinesterase inhibitors in dementia therapy.
Topics: Adult; Aged; Aged, 80 and over; Carbamates; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Middle Aged; Phenylcarbamates; Piperidines; Product Surveillance, Postmarketing; Rivastigmine; Surveys and Questionnaires; Tacrine; Treatment Outcome | 2003 |
Sex dimorphisms in the cognitive-enhancing action of the Alzheimer's drug donepezil in aged Rhesus monkeys.
Topics: Aging; Animals; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Macaca mulatta; Male; Piperidines; Psychomotor Performance; Sex Characteristics; Time Factors | 2003 |
[Early diagnosis and treatment of Alzheimer's disease. Implementation in the doctor's office].
Topics: Aged; Alzheimer Disease; Brief Psychiatric Rating Scale; Carbamates; Cholinesterase Inhibitors; Dihydroergotoxine; Donepezil; Family Practice; Female; Follow-Up Studies; Galantamine; Ginkgo biloba; Humans; Indans; Male; Memantine; Neuroprotective Agents; Nimodipine; Nootropic Agents; Phenylcarbamates; Piperidines; Piracetam; Psychiatric Status Rating Scales; Risk Factors; Rivastigmine; Time Factors; Vasodilator Agents | 2002 |
Mecamylamine interactions with galantamine and donepezil: effects on learning, acetylcholinesterase, and nicotinic acetylcholine receptors.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Female; Galantamine; Indans; Learning; Mecamylamine; Piperidines; Rabbits; Receptors, Nicotinic | 2003 |
Reversal of visual attention dysfunction after AMPA lesions of the nucleus basalis magnocellularis (NBM) by the cholinesterase inhibitor donepezil and by a 5-HT1A receptor antagonist WAY 100635.
Topics: Acetylcholine; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Attention; Basal Nucleus of Meynert; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Indans; Male; Photic Stimulation; Piperazines; Piperidines; Pyridines; Rats; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; Serotonin Antagonists | 2003 |
An observational clinical study of the efficacy and tolerability of donepezil in the treatment of Alzheimer's disease.
Topics: Activities of Daily Living; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Donepezil; Female; Humans; Indans; Male; Middle Aged; Parkinsonian Disorders; Piperidines; Product Surveillance, Postmarketing; Prospective Studies; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 2003 |
Long-term effects of donepezil on P300 auditory event-related potentials in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Event-Related Potentials, P300; Evoked Potentials, Auditory; Female; Follow-Up Studies; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Time Factors | 2003 |
Galantamine is an allosterically potentiating ligand of neuronal nicotinic but not of muscarinic acetylcholine receptors.
Topics: Allosteric Regulation; Animals; Carbamates; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Mice; Neurons; Phenylcarbamates; Piperidines; Receptors, Muscarinic; Receptors, Nicotinic; Recombinant Fusion Proteins; Rivastigmine; Tacrine; Trichlorfon | 2003 |
Neuroleptic malignant-like syndrome due to donepezil and maprotiline.
Topics: Aged; Alzheimer Disease; Antidepressive Agents, Second-Generation; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Humans; Indans; Male; Maprotiline; Neuroleptic Malignant Syndrome; Piperidines | 2003 |
The lowdown on Ginkgo biloba.
Topics: Acetylcarnitine; Acetylcholine; Alzheimer Disease; Animals; Antioxidants; Brain; Candy; Cognition; Dietary Sucrose; Dietary Supplements; Donepezil; Ginkgo biloba; Glucose; Humans; Indans; Memory; Neurotransmitter Agents; Phosphatidylcholines; Phosphatidylserines; Piperidines; Piracetam; Plant Extracts; Plant Preparations; Vinca Alkaloids | 2003 |
'Awakenings' in demented patients.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Awareness; Cholinesterase Inhibitors; Delusions; Depressive Disorder; Donepezil; Female; Humans; Indans; Piperidines; Risperidone; Schizophrenia; Schizophrenic Psychology; Sick Role | 2003 |
Discontinuation syndrome following donepezil cessation.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Middle Aged; Nootropic Agents; Piperidines; Substance Withdrawal Syndrome | 2003 |
Open-label study of donepezil in chronic poststroke aphasia.
Topics: Adult; Aged; Aphasia; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Pilot Projects; Piperidines; Severity of Illness Index; Stroke; Treatment Outcome | 2003 |
Evaluation of the binding characteristics of [5-(11)C-methoxy]Donepezil in the rat brain for in vivo visualization of acetylcholinesterase.
Topics: Acetylcholinesterase; Animals; Autoradiography; Brain; Brain Chemistry; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; In Vitro Techniques; Indans; Male; Piperidines; Radionuclide Imaging; Radiopharmaceuticals; Rats; Rats, Wistar | 2003 |
Acetylcholinesterase inhibitor (donepezil hydrochloride) reduces heart rate variability.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Heart Rate; Humans; Indans; Male; Piperidines | 2003 |
Cognitive enhancing properties and tolerability of cholinergic agents in mice: a comparative study of nicotine, donepezil, and SIB-1553A, a subtype-selective ligand for nicotinic acetylcholine receptors.
Topics: Age Factors; Animals; Attention; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cognition; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Drug Tolerance; Indans; Lethal Dose 50; Male; Mecamylamine; Memory, Short-Term; Mice; Mice, Inbred C57BL; Motor Activity; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Phenols; Piperidines; Psychomotor Performance; Pyrrolidines; Reaction Time; Receptors, Nicotinic; Scopolamine; Seizures | 2003 |
The value of the managed entry of new drugs: a case study of donepezil.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Decision Making; Donepezil; Drug Approval; Drug Evaluation; Drug Prescriptions; Drugs, Investigational; Health Care Rationing; Humans; Indans; Organizational Case Studies; Piperidines; Public Health Administration; State Medicine; United Kingdom | 2003 |
[Interaction of donepezil and muscular blockers in Alzheimer's disease].
Topics: Acetylcholine; Aged; Alzheimer Disease; Anesthesia, General; Atracurium; Cholinesterase Inhibitors; Colectomy; Diverticulum, Colon; Donepezil; Drug Interactions; Drug Therapy, Combination; Humans; Indans; Lorazepam; Male; Mianserin; Nootropic Agents; Piperidines; Succinylcholine | 2003 |
Co-use of donepezil and hypnotics among Alzheimer's disease patients living in the community.
Topics: Aged; Alzheimer Disease; Caregivers; Chi-Square Distribution; Cholinesterase Inhibitors; Cross-Sectional Studies; Data Collection; Donepezil; Female; Humans; Hypnotics and Sedatives; Indans; Male; Piperidines; Polypharmacy; Sleep Wake Disorders | 2003 |
Drugs in the news: an analysis of Canadian newspaper coverage of new prescription drugs.
Topics: Acetamides; Advertising; Anti-Inflammatory Agents, Non-Steroidal; Anticholesteremic Agents; Antiviral Agents; Atorvastatin; Bibliometrics; Canada; Celecoxib; Cholinesterase Inhibitors; Consumer Product Safety; Disclosure; Donepezil; Drug Industry; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Estrogen Antagonists; Heptanoic Acids; Humans; Indans; Newspapers as Topic; Oseltamivir; Patient Education as Topic; Piperidines; Pyrazoles; Pyrroles; Raloxifene Hydrochloride; Sulfonamides | 2003 |
Acetylcholine enhancement in the nucleus accumbens prevents addictive behaviors of cocaine and morphine.
Topics: Acetylcholine; Animals; Cholinesterase Inhibitors; Cocaine; Cocaine-Related Disorders; Conditioning, Psychological; Donepezil; Indans; Male; Mice; Mice, Inbred C57BL; Morphine; Morphine Dependence; Nucleus Accumbens; Pain; Piperidines; Substance Withdrawal Syndrome | 2003 |
Nicotinic acetylcholine receptor-mediated neuroprotection by donepezil against glutamate neurotoxicity in rat cortical neurons.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Donepezil; Drug Antagonism; Glutamic Acid; Indans; Neurons; Neuroprotective Agents; Neurotoxicity Syndromes; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic | 2003 |
Donepezil and athetosis in an elderly patient with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Athetosis; Donepezil; Humans; Indans; Male; Nootropic Agents; Piperidines | 2003 |
Clinical trials in stroke in 2002.
Topics: Anticholesteremic Agents; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Donepezil; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Piperidines; Stroke | 2003 |
Urinary incontinence with donepezil treatment in hospitalized children and adolescents with attention deficit hyperactivity disorder.
Topics: Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Inpatients; Male; Piperidines; Urinary Incontinence | 2003 |
Anticholinesterases in the treatment of Alzheimer's dementia--the first year's experience in Argyll & Clyde.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Protocols; Donepezil; Family Practice; Geriatric Assessment; Geriatric Psychiatry; Humans; Indans; Piperidines; Practice Guidelines as Topic; Scotland; State Medicine; Treatment Outcome | 2000 |
[Characteristics of MRI features in Alzheimer's disease patients predicting response to donepezil treatment].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Donepezil; Female; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Piperidines | 2003 |
Atrophy of the substantia innominata on magnetic resonance imaging predicts response to donepezil treatment in Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Atrophy; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Logistic Models; Magnetic Resonance Imaging; Male; Piperidines; Prognosis; Substantia Innominata; Treatment Outcome | 2003 |
[Determination of donepezil in human plasma by HPLC-MS].
Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Mass Spectrometry; Piperidines; Spectrometry, Mass, Electrospray Ionization | 2003 |
Aggressive behaviour associated with donepezil treatment: a case report.
Topics: Aged; Aggression; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Piperidines; Self-Injurious Behavior; Treatment Outcome | 2003 |
Frontotemporal dementia.
Topics: Age of Onset; Dementia; Donepezil; Fatal Outcome; Frontal Lobe; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Personality; Piperidines; tau Proteins; Temporal Lobe; Tomography, Emission-Computed, Single-Photon | 2003 |
Comparative study of donepezil and rivastigmine.
Topics: Carbamates; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2003 |
The effect of Aricept in persons with persistent memory disorder following traumatic brain injury: a pilot study.
Topics: Adult; Analysis of Variance; Brain Injuries; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Female; Humans; Indans; Male; Memory Disorders; Middle Aged; Pilot Projects; Piperidines; Psychiatric Status Rating Scales | 2003 |
Protective effect of donepezil in a primary culture of rat cortical neurons exposed to oxygen-glucose deprivation.
Topics: Animals; Cell Culture Techniques; Cell Hypoxia; Cells, Cultured; Cerebral Cortex; Donepezil; Glucose; Indans; Neurons; Neuroprotective Agents; Oxygen; Piperidines; Rats; Rats, Wistar | 2003 |
Cognitive decline in Down syndrome.
Topics: Adult; Age Factors; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Down Syndrome; Female; Humans; Indans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales | 2003 |
Donepezil for anticholinergic drug intoxication: a case report.
Topics: Amitriptyline; Cholinergic Antagonists; Delirium; Donepezil; Drug Overdose; Humans; Indans; Male; Middle Aged; Piperidines | 2003 |
Study of donepezil binding to serum albumin by capillary electrophoresis and circular dichroism.
Topics: Bilirubin; Binding Sites; Bromphenol Blue; Circular Dichroism; Donepezil; Electrophoresis, Capillary; Humans; Indans; Ketoprofen; Piperidines; Protein Binding; Reproducibility of Results; Serum Albumin; Time Factors; Warfarin | 2003 |
Beneficial effect of donepezil on sensorimotor function after stroke.
Topics: Cholinesterase Inhibitors; Donepezil; Female; Hemiplegia; Humans; Indans; Middle Aged; Piperidines; Psychomotor Performance; Stroke; Treatment Outcome | 2003 |
Donepezil and flight simulator performance: effects on retention of complex skills.
Topics: Aerospace Medicine; Cholinesterase Inhibitors; Cognition; Computer Simulation; Donepezil; Humans; Indans; Motor Skills; Piperidines; Reproducibility of Results; Retention, Psychology | 2003 |
The beneficial effect of donepezil on visual hallucinations in three patients with Parkinson's disease.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Hallucinations; Humans; Indans; Male; Middle Aged; Parkinson Disease; Piperidines; Psychomotor Disorders; Severity of Illness Index | 2003 |
The impact of drugs against dementia on cognition in aging and mild cognitive impairment.
Topics: Adult; Aged; Aged, 80 and over; Aging; Cognition; Cognition Disorders; Dementia; Donepezil; Female; Galantamine; Ginkgo biloba; Humans; Indans; Male; MEDLINE; Middle Aged; Nootropic Agents; Piperidines; Plant Extracts | 2003 |
Editorial comment--How to treat vascular dementia?
Topics: Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Donepezil; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Treatment Outcome | 2003 |
Donepezil for the treatment of a schizophrenia patient with frontal lobotomy.
Topics: Aged; Donepezil; Frontal Lobe; Humans; Indans; Male; Piperidines; Psychosurgery; Schizophrenia | 2003 |
Donepezil in a chronic drug user--a potential treatment?
Topics: Adult; Amphetamine-Related Disorders; Attention; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Memory Disorders; N-Methyl-3,4-methylenedioxyamphetamine; Neuropsychological Tests; Piperidines | 2003 |
Donepezil for the treatment of mild to moderate Alzheimer's disease in France: the economic implications.
Topics: Aged; Alzheimer Disease; Cost-Benefit Analysis; Donepezil; France; Health Expenditures; Humans; Indans; Models, Econometric; Nootropic Agents; Piperidines; Practice Patterns, Physicians'; Severity of Illness Index | 2004 |
[Memantine brakes Alzheimer's dementia. The NMDA antagonist is effective in severe cases, too].
Topics: Activities of Daily Living; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Dopamine Antagonists; Double-Blind Method; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Piperidines; Placebos; Randomized Controlled Trials as Topic; Time Factors | 2003 |
Alzheimer's drug delays move to nursing home.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Institutionalization; Nursing Homes; Piperidines; Time Factors | 2003 |
Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.
Topics: Acetylcholinesterase; Amino Acids, Aromatic; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Donepezil; Horses; Humans; Indans; Kinetics; Mice; Models, Molecular; Mutation; Piperidines; Protein Binding; Protein Structure, Tertiary; Structure-Activity Relationship; Thermodynamics | 2003 |
Donepezil in the treatment of mild to moderate Alzheimer's disease: report of a Belgian multicenter study.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Belgium; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines | 2003 |
Effect of donepezil on EEG spectral analysis in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Spectrum Analysis | 2003 |
Donepezil-responsive alcohol-related prolonged delirium.
Topics: Aged; Alcohol Withdrawal Delirium; Alcoholism; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2003 |
Severe worsening of parkinsonism in Lewy body dementia due to donepezil.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Lewy Body Disease; Piperidines | 2003 |
Effects of donepezil on DOI-induced head twitch response in mice: implications for Tourette syndrome.
Topics: Amphetamines; Animals; Donepezil; Drug Synergism; Head Movements; Indans; Male; Mecamylamine; Mice; Mice, Inbred ICR; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Piperidines; Serotonin Receptor Agonists; Tics; Time Factors; Tourette Syndrome | 2003 |
Donepezil in vascular dementia: a viewpoint by David S. Geldmacher.
Topics: Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Piperidines | 2003 |
Donepezil in vascular dementia: a viewpoint by Gustavo C. Román.
Topics: Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Piperidines | 2003 |
Donepezil in vascular dementia: a viewpoint by Sandra E. Black.
Topics: Administration, Oral; Cholinesterase Inhibitors; Clinical Trials as Topic; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Humans; Indans; Piperidines; Psychiatric Status Rating Scales | 2003 |
Galantamine vs donepezil in the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Humans; Indans; Piperidines | 2003 |
[A case of acute cholinergic adverse effects induced by donepezil overdose: a follow-up of clinical course and plasma concentration of donepezil].
Topics: Aged; Alzheimer Disease; Arrhythmia, Sinus; Bradycardia; Cholinesterase Inhibitors; Donepezil; Drug Overdose; Electrocardiography; Female; Humans; Indans; Piperidines; Vomiting | 2003 |
Can donepezil be considered a mild antipsychotic in dementia treatment? A report of donepezil use in 6 patients.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Female; Hallucinations; Humans; Indans; Male; Mental Status Schedule; Piperidines; Treatment Outcome | 2003 |
Pharmacologic treatment expectations in the management of dementia with Lewy bodies.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Brain; Carbamates; Cholinesterase Inhibitors; Diagnosis, Differential; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Nootropic Agents; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2004 |
Ignoring the controversies: newspaper reports on Alzheimer's disease treatments.
Topics: Alzheimer Disease; Canada; Donepezil; Humans; Indans; Newspapers as Topic; Nootropic Agents; Piperidines; United Kingdom; United States; Vitamin E | 2003 |
No donepezil discontinuation effect in patients with Alzheimer's disease who were switched to rivastigmine after failing to benefit from donepezil treatment.
Topics: Aged; Alzheimer Disease; Carbamates; Donepezil; Female; Humans; Indans; Male; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Failure; Treatment Outcome | 2003 |
[Significance of treatment and adequate care in dementia--including point of medical comments in health care insurance system for elderly people by doctors].
Topics: Aged; Alzheimer Disease; Dementia; Donepezil; Health Services for the Aged; Humans; Indans; Insurance, Health; Neuropsychological Tests; Nootropic Agents; Piperidines; Quality of Life | 2003 |
Efficacy and safety of donepezil in patients with Alzheimer's disease: results of a global, multinational, clinical experience study.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Social Behavior; Treatment Outcome | 2004 |
Two cases of quetiapine augmentation for donepezil-refractory visual hallucinations in dementia with Lewy bodies.
Topics: Aged; Antipsychotic Agents; Dibenzothiazepines; Donepezil; Drug Resistance; Drug Synergism; Drug Therapy, Combination; Female; Hallucinations; Humans; Indans; Lewy Body Disease; Male; Nootropic Agents; Piperidines; Quetiapine Fumarate | 2003 |
Neuroleptic malignant syndrome induced by donepezil.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Lewy Body Disease; Neuroleptic Malignant Syndrome; Piperidines | 2004 |
Technical issues in the determination of cerebrovascular reserve in elderly subjects using 15O-water PET imaging.
Topics: Acetazolamide; Aged; Aged, 80 and over; Aging; Alzheimer Disease; Attention; Blood Flow Velocity; Brain; Donepezil; Female; Humans; Indans; Male; Mental Recall; Nootropic Agents; Oxygen Consumption; Oxygen Radioisotopes; Piperidines; Reference Values; Tomography, Emission-Computed; Vasodilation; Verbal Learning | 2004 |
Donepezil modulates nicotinic receptors of substantia nigra dopaminergic neurones.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Dopamine; Electrophysiology; In Vitro Techniques; Indans; Insecticides; Membrane Potentials; Neurons; Nicotine; Nicotinic Agonists; Nootropic Agents; Organothiophosphorus Compounds; Patch-Clamp Techniques; Piperidines; Rats; Receptors, Nicotinic; Substantia Nigra; Synapses; Synaptic Transmission | 2004 |
Pharmacology of selective acetylcholinesterase inhibitors: implications for use in Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Animals; Brain; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice; Physostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Tacrine | 2004 |
Antagonism of anticholinesterase (DFP) toxicity by donepezil plus scopolamine: a preliminary study.
Topics: Animals; Behavior, Animal; Body Temperature; Cholinesterase Inhibitors; Diarrhea; Donepezil; Drug Interactions; Indans; Isoflurophate; Male; Motor Activity; Muscarinic Antagonists; Neurotoxicity Syndromes; Piperidines; Rats; Scopolamine | 2004 |
Significance of syncope in patients with Alzheimer's disease treated with cholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Pacemaker, Artificial; Piperidines; Syncope | 2003 |
Effects of acute acetylcholinesterase inhibition on the cerebral cholinergic neuronal system and cognitive function: Functional imaging of the conscious monkey brain using animal PET in combination with microdialysis.
Topics: Aging; Animals; Behavior, Animal; Carbon Radioisotopes; Cholinergic Fibers; Cholinesterase Inhibitors; Cognition; Consciousness; Donepezil; Indans; Macaca mulatta; Male; Memory, Short-Term; Microdialysis; Models, Animal; Piperidines; Prefrontal Cortex; Tomography, Emission-Computed | 2004 |
Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro.
Topics: Aconitine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Hippocampus; In Vitro Techniques; Indans; Male; Nicotinic Agonists; Nicotinic Antagonists; Pheochromocytoma; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2003 |
A case history illustrating how extended release cholinesterase inhibitors could improve management of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Carbamates; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine | 2003 |
Drug treatment of REM sleep behavior disorders in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Ambulatory Care; Benzodiazepines; Cholinesterase Inhibitors; Clonazepam; Donepezil; Dose-Response Relationship, Drug; Female; Globus Pallidus; Humans; Indans; Lewy Body Disease; Locus Coeruleus; Male; Mental Status Schedule; Middle Aged; Nerve Net; Pedunculopontine Tegmental Nucleus; Piperidines; REM Sleep Behavior Disorder; Sleep-Wake Transition Disorders; Sleep, REM; Treatment Outcome; Violence | 2003 |
Donepezil minimally effective for patients with vascular dementia.
Topics: Aged; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Donepezil; Double-Blind Method; Humans; Indans; Multicenter Studies as Topic; Piperidines; Randomized Controlled Trials as Topic; Reproducibility of Results | 2004 |
Emerging therapies for vascular dementia and vascular cognitive impairment.
Topics: Carbamates; Cardiovascular Diseases; Cerebrovascular Disorders; Cholinesterase Inhibitors; Cognition Disorders; Controlled Clinical Trials as Topic; Dementia, Vascular; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Risk Factors; Rivastigmine; Stroke; Terminology as Topic | 2004 |
Academic highlights: emerging therapeutic strategies in Alzheimer's disease.
Topics: Alzheimer Disease; Brain; Combined Modality Therapy; Diagnosis, Differential; Disease Progression; Donepezil; Humans; Indans; Memantine; Mental Status Schedule; Piperidines; Randomized Controlled Trials as Topic; Receptors, N-Methyl-D-Aspartate; Tomography, Emission-Computed | 2004 |
Enhanced cutaneous vascular response in AD subjects under donepezil therapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Donepezil; Drug Synergism; Female; Humans; Indans; Male; Middle Aged; Piperidines; Skin; Vasodilation; Vasodilator Agents | 2004 |
[A study of the effect of donepezil hydrochloride on cognitive function in patients with dementia of Alzheimer's type using WAIS-R].
Topics: Aged; Alzheimer Disease; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Wechsler Scales | 2004 |
Donepezil for alcohol-related dementia: a case report.
Topics: Aged; Alcohol-Related Disorders; Cognition Disorders; Donepezil; Drug Administration Schedule; Humans; Indans; Injections; Male; Piperidines; Time Factors; Treatment Outcome; Vitamin B 12; Vitamin B 12 Deficiency | 2004 |
Functional screening of drug target genes: m1 muscarinic acetylcholine receptor phenotypes in degenerative dementias.
Topics: Aged; Cholinesterase Inhibitors; Cohort Studies; Dementia; DNA; Donepezil; Drug Delivery Systems; Female; Genetic Testing; Humans; Indans; Male; Neurodegenerative Diseases; Nootropic Agents; Phenotype; Piperidines; Polymorphism, Genetic; Receptor, Muscarinic M1; Receptors, Muscarinic; Reverse Transcriptase Polymerase Chain Reaction | 2004 |
Memantine for patients with Alzheimer disease.
Topics: Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Dopamine Agents; Excitatory Amino Acid Antagonists; Humans; Indans; Memantine; Nootropic Agents; Piperidines; Quality of Life | 2004 |
The T-maze continuous alternation task for assessing the effects of putative cognition enhancers in the mouse.
Topics: Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Drug Administration Routes; Exploratory Behavior; Indans; Maze Learning; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Piperidines; Reaction Time; Reproducibility of Results; Scopolamine; Space Perception; Species Specificity; Time Factors | 2004 |
Another advertisement for donepezil.
Topics: Advertising; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Institutionalization; Nootropic Agents; Nursing Homes; Patient Compliance; Piperidines; Time Factors | 2004 |
Donepezil's effects remain uncertain.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Follow-Up Studies; Humans; Indans; Institutionalization; Models, Theoretical; Nootropic Agents; Nursing Homes; Patient Compliance; Piperidines; Placebos; Randomized Controlled Trials as Topic; Time Factors | 2004 |
Donepezil delay to nursing home placement study is flawed.
Topics: Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Controlled Clinical Trials as Topic; Donepezil; Humans; Indans; Institutionalization; Nootropic Agents; Nursing Homes; Piperidines; Randomized Controlled Trials as Topic; Research; Time Factors; Treatment Outcome | 2004 |
Donepezil use in Down syndrome.
Topics: Adult; Cholinesterase Inhibitors; Dementia; Donepezil; Down Syndrome; Humans; Indans; Neuropsychological Tests; Pilot Projects; Piperidines; Treatment Outcome | 2004 |
The effects of Ginkgo biloba extracts on the pharmacokinetics and pharmacodynamics of donepezil.
Topics: Administration, Oral; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Chromatography, High Pressure Liquid; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Interactions; Drug Therapy, Combination; Erythrocytes; Female; Ginkgo biloba; Humans; Indans; Male; Mental Status Schedule; Phytotherapy; Piperidines; Plant Extracts; Plant Leaves; Plants, Medicinal; Time Factors | 2004 |
Treatment of urinary incontinence with anticholinergics in patients taking cholinesterase inhibitors for dementia.
Topics: Aged; Benzhydryl Compounds; Cholinesterase Inhibitors; Cresols; Dementia; Donepezil; Drug Interactions; Drug Therapy, Combination; Female; Humans; Indans; Muscarinic Antagonists; Phenylpropanolamine; Piperidines; Tolterodine Tartrate; Urinary Incontinence | 2004 |
Effects of donepezil on motor function in patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Donepezil; Female; Humans; Indans; Male; Middle Aged; Motor Skills; Piperidines | 2004 |
Donepezil use in US nursing homes.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Drug Utilization; Female; Humans; Indans; Male; Nootropic Agents; Nursing Homes; Piperidines; Treatment Outcome; United States | 2004 |
Comparative effects of huperzine A, donepezil and rivastigmine on cortical acetylcholine level and acetylcholinesterase activity in rats.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Brain Chemistry; Carbamates; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fasciculation; Indans; Male; Neurons; Phenylcarbamates; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Sesquiterpenes; Up-Regulation | 2004 |
Cholinergic enhancement of frontal lobe activity in mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Frontal Lobe; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Piperidines | 2004 |
Effect of donepezil on group II mGlu receptor agonist- or antagonist-induced amnesia on passive avoidance in mice.
Topics: Amino Acids; Amnesia; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cyclopropanes; Donepezil; Excitatory Amino Acid Antagonists; Glycine; Indans; Male; Memory; Mice; Nootropic Agents; Piperidines; Receptors, Metabotropic Glutamate; Xanthenes | 2003 |
Comparison of the effect of TAK-147 (zanapezil) and E-2020 (donepezil) on extracellular acetylcholine level and blood flow in the ventral hippocampus of freely moving rats.
Topics: Acetylcholine; Animals; Benzazepines; Donepezil; Dose-Response Relationship, Drug; Extracellular Fluid; Hippocampus; Indans; Male; Piperidines; Rats; Rats, Wistar | 2004 |
Delay in nursing home placement with donepezil.
Topics: Aged; Alzheimer Disease; Bias; Cholinesterase Inhibitors; Data Interpretation, Statistical; Disease Progression; Donepezil; Humans; Indans; Institutionalization; Nursing Homes; Piperidines; Research Design | 2004 |
A case study in the treatment of dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Carbamates; Cognition Disorders; Donepezil; Drug Resistance; Female; Galantamine; Hallucinations; Humans; Indans; Lewy Body Disease; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Psychomotor Agitation; Rivastigmine; Social Behavior | 2004 |
The effects of Donepezil on traumatic brain injury acute rehabilitation outcomes.
Topics: Adult; Analysis of Variance; Brain Injuries; Cognition Disorders; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Length of Stay; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Rehabilitation Centers; Retrospective Studies; Treatment Outcome | 2004 |
ECT-donepezil interaction: a single case report.
Topics: Aged; Cholinesterase Inhibitors; Combined Modality Therapy; Depressive Disorder; Donepezil; Electroconvulsive Therapy; Humans; Indans; Male; Piperidines | 2004 |
AD2000: donepezil in Alzheimer's disease.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cost-Benefit Analysis; Donepezil; Drug Industry; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2004 |
Feeling cold after donepezil.
Topics: Body Temperature Regulation; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Somatosensory Disorders | 2004 |
Pruned receptor surface models and pharmacophores for three-dimensional database searching.
Topics: Amidines; Angiotensin-Converting Enzyme Inhibitors; Benzodiazepines; Celecoxib; Cholinesterase Inhibitors; Cyclooxygenase 2; Databases, Factual; Donepezil; Enalapril; Enzymes; Estradiol; Imidazoles; Indans; Isoenzymes; Ligands; Models, Molecular; Molecular Structure; Naphthalenes; Piperidines; Prostaglandin-Endoperoxide Synthases; Pyrazoles; Quantitative Structure-Activity Relationship; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Receptors, GABA-A; Sulfonamides; Thrombin | 2004 |
Understanding the latest advances in pharmacologic interventions for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Antioxidants; Carbamates; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Receptors, N-Methyl-D-Aspartate; Rivastigmine; Treatment Outcome | 2004 |
Mortality in donepezil-treated patients.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2004 |
Donepezil therapy for neuropsychiatric symptoms in AD: methods make the message.
Topics: Alzheimer Disease; Donepezil; Double-Blind Method; Humans; Indans; Nootropic Agents; Patient Dropouts; Piperidines; Randomized Controlled Trials as Topic; Research Design; Severity of Illness Index; Treatment Outcome; Withholding Treatment | 2004 |
Efficacy of donepezil treatment in Alzheimer patients with and without subcortical vascular lesions.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Comorbidity; Dementia, Vascular; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Registries; Treatment Outcome | 2004 |
[Significance of treatment and adequate care in dementia--including point of medical comments in health care insurance system for elderly people by doctors].
Topics: Aged; Alzheimer Disease; Cognition; Donepezil; Female; Humans; Indans; Insurance, Health; Neuropsychological Tests; Nootropic Agents; Physicians, Family; Piperidines; Quality of Life | 2003 |
Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys.
Topics: Age Factors; Aging; Animals; Cognition; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Macaca mulatta; Male; Memory Disorders; Neuropsychological Tests; Nootropic Agents; Piperidines; Recovery of Function; Sex Factors; Treatment Outcome | 2004 |
Cholinergic drugs for Alzheimer's disease enhance in vitro dopamine release.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Galantamine; Indans; Mice; Piperidines; Receptors, Nicotinic | 2004 |
Synthesis and evaluation of tacrine-E2020 hybrids as acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; Ligands; Models, Molecular; Nootropic Agents; Piperidines; Rats; Structure-Activity Relationship; Tacrine | 2004 |
Identification and characterization of potential impurities of donepezil.
Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Structure; Piperidines; Spectroscopy, Fourier Transform Infrared | 2004 |
Acetylcholinesterase inhibitors increase ADAM10 activity by promoting its trafficking in neuroblastoma cell lines.
Topics: Acetylcholinesterase; ADAM Proteins; ADAM10 Protein; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Atropine; Blotting, Western; Brefeldin A; Bungarotoxins; Carbachol; Cell Differentiation; Cell Fractionation; Cell Line, Tumor; Cholinergic Agonists; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Embryo, Mammalian; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Humans; Indans; Membrane Proteins; Metalloendopeptidases; Microscopy, Confocal; Muscarinic Antagonists; Neuroblastoma; Physostigmine; Piperidines; Protein Synthesis Inhibitors; Protein Transport; Tretinoin | 2004 |
9th International Conference on AD and related disorders (ICAD).
Topics: Alzheimer Disease; Alzheimer Vaccines; Amyloid beta-Peptides; Donepezil; Humans; Hypoglycemic Agents; Indans; Mannich Bases; Nootropic Agents; Piperidines; Rosiglitazone; Thiazolidinediones | 2004 |
Delaying Alzheimer's. In a new study, Aricept held it off for 18 months. Is this drug right for you?
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Placebos; Randomized Controlled Trials as Topic; Treatment Outcome; United States; Vitamin E | 2004 |
Potential treatment effects of donepezil not detected in Alzheimer's disease clinical trials: a physician survey.
Topics: Activities of Daily Living; Affect; Aged; Alzheimer Disease; Attention; Behavior; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Physicians, Family; Piperidines; Social Behavior; Surveys and Questionnaires; Treatment Outcome | 2004 |
[Limited efficacy of cholinesterase inhibitors in Alzheimer's dementia].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2004 |
[Efficacy, efficiency and evidence -- studies on donepezil].
Topics: Aged; Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2004 |
Effects of the cholinesterase inhibitors donepezil and metrifonate on scopolamine-induced impairments in the spatial cone field orientation task in rats.
Topics: Animals; Brain; Cholinesterase Inhibitors; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Memory, Short-Term; Mental Recall; Motivation; Motor Activity; Nootropic Agents; Orientation; Piperidines; Rats; Rats, Wistar; Reaction Time; Scopolamine; Space Perception; Trichlorfon | 2005 |
Efficacy of acetylcholinesterase inhibitors in frontotemporal dementia.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2004 |
A docking score function for estimating ligand-protein interactions: application to acetylcholinesterase inhibition.
Topics: Acetylcholinesterase; Binding Sites; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Humans; Indans; Ligands; Models, Molecular; Molecular Structure; Mutagenesis, Site-Directed; Piperidines; Protein Binding; Quantitative Structure-Activity Relationship | 2004 |
Treatment of typical Charles Bonnet syndrome with donepezil.
Topics: Aged; Cholinesterase Inhibitors; Diagnosis, Differential; Donepezil; Dose-Response Relationship, Drug; Female; Hallucinations; Humans; Indans; Piperidines; Vision Disorders | 2004 |
Enhancement of purinergic neurotransmission by galantamine and other acetylcholinesterase inhibitors in the rat vas deferens.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Electric Stimulation; Galantamine; In Vitro Techniques; Indans; Male; Muscle Contraction; Muscle, Smooth; Nicotine; Nicotinic Agonists; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Receptors, Purinergic; Rivastigmine; Stimulation, Chemical; Synaptic Transmission; Tacrine; Vas Deferens | 2004 |
Donepezil and cardiac syncope: case report.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electrocardiography, Ambulatory; Female; Humans; Indans; Piperidines; Syncope | 2004 |
Severe worsening of parkinsonism in Lewy body dementia due to donepezil.
Topics: Acetylcholine; Aged; Basal Ganglia; Cholinesterase Inhibitors; Disease Progression; Donepezil; Dopamine; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced; Female; Humans; Indans; Lewy Body Disease; Parkinsonian Disorders; Piperidines | 2004 |
Switching from donepezil or rivastigmine to galantamine in clinical practice.
Topics: Alzheimer Disease; Donepezil; Galantamine; Humans; Indans; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine | 2004 |
Drug therapy in Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Humans; Indans; Piperidines; Practice Guidelines as Topic | 2004 |
Treating cognitive deficits in multiple sclerosis: are we there yet?
Topics: Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Memory; Multiple Sclerosis; Nootropic Agents; Piperidines | 2004 |
Alzheimer's drugs: are they worth it?
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Treatment Outcome | 2004 |
Novel neuronal targets for the acetylcholinesterase inhibitor donepezil.
Topics: Cell Cycle; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Delivery Systems; Humans; Indans; Neurons; Piperidines | 2004 |
Impact of rivastigmine use on the risk of nursing home placement in a US sample.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Databases, Factual; Donepezil; Drug Utilization Review; Female; Humans; Indans; Insurance; Male; Nursing Homes; Phenylcarbamates; Piperidines; Proportional Hazards Models; Retrospective Studies; Risk Assessment; Rivastigmine; Time Factors; United States | 2004 |
Common Alzheimer's drug flunks test of effectiveness. Initial improvements in cognitive ability made by cholinesterase inhibitors soon disappear.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Treatment Failure | 2004 |
[A patient with probable dementia with Lewy bodies, who showed catatonia induced by donepezil: a case report].
Topics: Aged; Catatonia; Donepezil; Female; Hallucinations; Humans; Indans; Lewy Body Disease; Nootropic Agents; Parkinsonian Disorders; Piperidines | 2004 |
Severe delirium due to basal forebrain vascular lesion and efficacy of donepezil.
Topics: Aged; Basal Ganglia Cerebrovascular Disease; Basal Nucleus of Meynert; Craniopharyngioma; Delirium; Donepezil; Humans; Indans; Magnetic Resonance Imaging; Male; Nootropic Agents; Piperidines; Pituitary Neoplasms; Postoperative Complications; Prosencephalon; Sleep Wake Disorders; Vision Disorders | 2004 |
One-year change in cerebral glucose metabolism in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Brain Chemistry; Brain Mapping; Disease Progression; Donepezil; Female; Fluorodeoxyglucose F18; Glucose; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Nootropic Agents; Piperidines; Radionuclide Imaging; Radiopharmaceuticals | 2004 |
Dissociable effects of acetylcholinesterase inhibitors and phosphodiesterase type 5 inhibitors on object recognition memory: acquisition versus consolidation.
Topics: 3',5'-Cyclic-GMP Phosphodiesterases; Animals; Cholinesterase Inhibitors; Cyclic Nucleotide Phosphodiesterases, Type 5; Discrimination, Psychological; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Memory; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Piperidines; Purines; Rats; Rats, Wistar; Recognition, Psychology; Sildenafil Citrate; Sulfones; Trichlorfon | 2005 |
[Nightmares in patients with Alzheimer's disease caused by donepezil. Therapeutic effect depends on the time of intake].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Dreams; Drug Administration Schedule; Female; Humans; Indans; Male; Middle Aged; Night Terrors; Nootropic Agents; Piperidines; Time Factors; Treatment Outcome | 2005 |
[An interventional study on amnestic mild cognitive impairment with small dose donepezil].
Topics: Aged; Aged, 80 and over; Amnesia; Aspartic Acid; Cognition; Cognition Disorders; Creatine; Donepezil; Female; Hippocampus; Humans; Indans; Inositol; Magnetic Resonance Spectroscopy; Male; Memory; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines | 2004 |
Not all head-to-head trials are created equal: results from an open-label, short-term study seem inconsistent with previous donepezil literature.
Topics: Aged; Alzheimer Disease; Caregivers; Cognition; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome | 2005 |
Symptomatic effect of donepezil, rivastigmine, galantamine and memantine on cognitive deficits in the APP23 model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Galantamine; Humans; Indans; Male; Memantine; Mice; Mice, Mutant Strains; Phenylcarbamates; Piperidines; Rivastigmine; Sensitivity and Specificity | 2005 |
Donepezil for memory impairment in multiple sclerosis.
Topics: Cholinesterase Inhibitors; Donepezil; Humans; Indans; Memory Disorders; Multiple Sclerosis; Piperidines; Randomized Controlled Trials as Topic | 2005 |
Beneficial effect of donepezil in the treatment of elderly patients with tardive movement disorders.
Topics: Aged; Antipsychotic Agents; Basal Ganglia Diseases; Bipolar Disorder; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Dyskinesia, Drug-Induced; Female; Geriatric Assessment; Hospitalization; Humans; Indans; Male; Middle Aged; Piperidines; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenic Psychology; Severity of Illness Index; Treatment Outcome | 2005 |
Does donepezil improve well-being for dementia due to Alzheimer's disease?
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Piperidines; Quality of Life; Randomized Controlled Trials as Topic; Treatment Outcome | 2005 |
Donepezil blocks voltage-gated ion channels in rat dissociated hippocampal neurons.
Topics: Animals; Animals, Newborn; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Indans; Ion Channels; Kinetics; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Potassium Channels; Pyramidal Cells; Rats; Rats, Sprague-Dawley; Sodium Channels | 2005 |
Donepezil and tardive dyskinesia.
Topics: Adolescent; Cholinesterase Inhibitors; Donepezil; Dyskinesia, Drug-Induced; Humans; Indans; Male; Piperidines | 2005 |
Brain levels and acetylcholinesterase inhibition with galantamine and donepezil in rats, mice, and rabbits.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Galantamine; Indans; Male; Mice; Mice, Inbred C57BL; Piperidines; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity | 2005 |
Dramatic improvement in Down syndrome-associated cognitive impairment with donepezil.
Topics: Adult; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Down Syndrome; Female; Humans; Indans; Intellectual Disability; Male; Piperidines; Quality of Life | 2005 |
Novel dimeric acetylcholinesterase inhibitor bis7-tacrine, but not donepezil, prevents glutamate-induced neuronal apoptosis by blocking N-methyl-D-aspartate receptors.
Topics: Animals; Apoptosis; Cells, Cultured; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Glutamic Acid; Indans; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Tacrine | 2005 |
Action of cholinesterase inhibitors in patients' brains.
Topics: Acetylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Cognition; Donepezil; Humans; Indans; Piperidines | 2005 |
Successfully switching acetylcholinesterase inhibitor therapy in probable Lewy body dementia.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Lewy Body Disease; Neuroprotective Agents; Phenylcarbamates; Piperidines; Rivastigmine; Sweating | 2005 |
NICE proposes to withdraw Alzheimer's drugs from NHS.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Drug Costs; England; Formularies as Topic; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Rivastigmine; State Medicine; Wales | 2005 |
Cholinesterase inhibitors exert a protective effect on endothelial damage in Alzheimer disease patients.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Endothelium, Vascular; Female; Hemostasis; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Piperidines; Risk Factors | 2005 |
Acetylcholinesterase inhibitors effects on oncostatin-M, interleukin-1 beta and interleukin-6 release from lymphocytes of Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cells, Cultured; Cholinesterase Inhibitors; Cytokines; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Interleukin-1; Interleukin-6; Leukocytes, Mononuclear; Male; Oncostatin M; Peptides; Piperidines | 2005 |
Acetylcholinesterase inhibitors ameliorate behavioral deficits in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Psychological; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Fear; Genetics, Behavioral; Heterozygote; Humans; Indans; Learning; Memory; Memory Disorders; Mice; Mice, Transgenic; Physostigmine; Piperidines; Plaque, Amyloid; Spatial Behavior | 2005 |
Treating dementia patients with vascular lesions with donepezil: a preliminary analysis.
Topics: Aged; Alzheimer Disease; Blood Vessels; Brain; Dementia; Dementia, Vascular; Donepezil; Female; Humans; Indans; Male; Memory; Memory, Short-Term; Mental Recall; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Stroke | 2005 |
Searching for methods to detect, prevent, and treat Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Occipital Lobe; Piperidines; Predictive Value of Tests; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Treatment Outcome | 2005 |
Drug persistency patterns for patients treated with rivastigmine or donepezil in usual care settings.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Drug Administration Schedule; Female; Humans; Indans; Male; Patient Dropouts; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine | 2005 |
Economic evaluation of donepezil in moderate to severe Alzheimer disease.
Topics: Alzheimer Disease; Cost-Benefit Analysis; Donepezil; Humans; Indans; Neuropharmacology; Nootropic Agents; Piperidines; Placebos; Reproducibility of Results | 2005 |
Mild cognitive impairment--no benefit from vitamin E, little from donepezil.
Topics: Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Treatment Failure; Vitamin E | 2005 |
Effect of donepezil and lercanidipine on memory impairment induced by intracerebroventricular streptozotocin in rats.
Topics: Animals; Avoidance Learning; Brain; Calcium Channel Blockers; Cerebral Ventricles; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Dihydropyridines; Donepezil; Drug Combinations; Indans; Injections; Male; Maze Learning; Memory; Memory Disorders; Piperidines; Rats; Rats, Sprague-Dawley; Streptozocin | 2005 |
[Protective effect of Danzhi-xiaoyao San on rat brain energy or material metabolism (correction of matebolism) dealt with D-galactose].
Topics: Aldehyde Reductase; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; DNA; Donepezil; Drugs, Chinese Herbal; Galactose; Indans; Nootropic Agents; Piperidines; Proteins; Rats; Rats, Wistar; RNA, Messenger | 2005 |
Neuroprotective effect of donepezil, a nicotinic acetylcholine-receptor activator, on cerebral infarction in rats.
Topics: Animals; Donepezil; Indans; Infarction, Middle Cerebral Artery; Ischemic Preconditioning; Male; Neuroprotective Agents; Nicotinic Agonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2005 |
Protective effect of donepezil against Abeta(1-40) neurotoxicity in rat septal neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Peptides; Animals; Benzothiazoles; Cells, Cultured; Cholinergic Fibers; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Fluorescent Dyes; Immunohistochemistry; Indans; L-Lactate Dehydrogenase; Membrane Transport Proteins; Molecular Structure; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei; Thiazoles; Vesicular Acetylcholine Transport Proteins | 2005 |
Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats.
Topics: Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Conditioning, Operant; Donepezil; Drug Administration Routes; Drug Interactions; Excitatory Amino Acid Antagonists; Food Deprivation; Hippocampus; Indans; Male; Memantine; Memory Disorders; Peptide Fragments; Piperidines; Rats; Rats, Inbred F344; Reaction Time; Time Factors | 2005 |
Donepezil improved memory in multiple sclerosis in a randomized clinical trial.
Topics: Artifacts; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Humans; Indans; Memory Disorders; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Reproducibility of Results; Research Design; Treatment Outcome; Urinary Bladder, Neurogenic | 2005 |
[Post-marketing observational study of donepezil].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Drug Therapy, Combination; Humans; Indans; Nootropic Agents; Piperidines; Product Surveillance, Postmarketing; Retreatment; Treatment Outcome | 2005 |
Donepezil, tacrine and alpha-phenyl-n-tert-butyl nitrone (PBN) inhibit choline transport by conditionally immortalized rat brain capillary endothelial cell lines (TR-BBB).
Topics: Animals; Biological Transport; Blood-Brain Barrier; Brain; Cell Line, Transformed; Central Nervous System Agents; Choline; Cyclic N-Oxides; Donepezil; Endothelial Cells; Indans; Models, Biological; Nerve Tissue Proteins; Nitrogen Oxides; Organic Cation Transport Proteins; Piperidines; Plasma Membrane Neurotransmitter Transport Proteins; Rats; Symporters; Tacrine | 2005 |
Estimation of plasma IC50 of donepezil hydrochloride for brain acetylcholinesterase inhibition in monkey using N-[11C]methylpiperidin-4-yl acetate ([11C]MP4A) and PET.
Topics: Acetylcholinesterase; Algorithms; Animals; Brain; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Indans; Injections, Intravenous; Macaca mulatta; Male; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals | 2005 |
Expression and production of two selected beta-chemokines in peripheral blood mononuclear cells from patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Chemokine CCL2; Chemokine CCL5; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Leukocytes, Mononuclear; Male; Piperidines; RNA, Messenger | 2005 |
Combination drug therapies for AD: progress is slow, but we must keep trying.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Estrogens; Excitatory Amino Acid Antagonists; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Memantine; Piperidines | 2005 |
Modulation of N-methyl-D-aspartate receptors by donepezil in rat cortical neurons.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cyclic AMP-Dependent Protein Kinases; Donepezil; Dose-Response Relationship, Drug; Female; GTP-Binding Proteins; Indans; Neurons; Nootropic Agents; Piperidines; Pregnancy; Protein Kinase C; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate | 2005 |
Effect of oral administration of zanapezil (TAK-147) for 21 days on acetylcholine and monoamines levels in the ventral hippocampus of freely moving rats.
Topics: Acetylcholine; Administration, Oral; Animals; Benzazepines; Biogenic Monoamines; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Hippocampus; Indans; Male; Microdialysis; Piperidines; Rats; Rats, Wistar; Time Factors | 2005 |
Cholinesterase inhibitors ameliorate behavioral deficits induced by MK-801 in mice.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognition; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Galantamine; Indans; Learning; Male; Maze Learning; Mice; Mice, Inbred C57BL; Physostigmine; Piperidines; Receptors, Nicotinic | 2005 |
Change in perfusion, hallucinations and fluctuations in consciousness in dementia with Lewy bodies.
Topics: Aged; Cholinesterase Inhibitors; Consciousness Disorders; Donepezil; Female; Hallucinations; Hemodynamics; Humans; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Oximes; Piperidines; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon | 2005 |
Cholinesterase inhibitors for treatment of dementia associated with Parkinson's disease.
Topics: Cholinesterase Inhibitors; Comorbidity; Cross-Over Studies; Cross-Sectional Studies; Dementia; Donepezil; Double-Blind Method; Humans; Indans; Mental Status Schedule; Neuropsychological Tests; Outcome Assessment, Health Care; Parkinson Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2005 |
[Donepezil in patients with Alzheimer's disease--a critical appraisal of the AD2000 study].
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Quality of Life; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome | 2005 |
Effect of donepezil in patients with Alzheimer's disease previously untreated or treated with memantine or nootropic agents in Germany: an observational study.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Germany; Humans; Indans; Male; Memantine; Middle Aged; Nootropic Agents; Observation; Piperidines; Product Surveillance, Postmarketing; Prospective Studies; Quality of Life; Receptors, N-Methyl-D-Aspartate; Treatment Outcome | 2005 |
One-year treatment of Alzheimer's disease with acetylcholinesterase inhibitors: improvement on ADAS-cog and TMT A, no change or worsening on other tests.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Psychomotor Performance; Rivastigmine | 2005 |
Drug may temporarily slow progression of mild cognitive impairment.
Topics: Alzheimer Disease; Cognition Disorders; Donepezil; Female; Humans; Indans; Nootropic Agents; Piperidines; Vitamin E | 2005 |
Quantitative electroencephalogram analysis in dementia with Lewy bodies and Alzheimer's disease.
Topics: Aged; Algorithms; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Functional Laterality; Humans; Indans; Lewy Body Disease; Male; Piperidines | 2005 |
Inhibition of human plasma cholinesterase by malachite green and related triarylmethane dyes: mechanistic implications.
Topics: Binding Sites; Butyrylthiocholine; Choline; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Humans; Hydrogen-Ion Concentration; Indans; Kinetics; Ligands; Methyl Green; Peripheral Nerves; Phenothiazines; Piperidines; Propidium; Rosaniline Dyes; Temperature; Toluidines | 2005 |
Effects of donepezil, nicotine and haloperidol on the central serotonergic system in mice: implications for Tourette's syndrome.
Topics: Amphetamines; Animals; Behavior, Animal; Binding, Competitive; Cerebral Cortex; Corpus Striatum; Donepezil; Dose-Response Relationship, Drug; Frontal Lobe; Gene Expression; Haloperidol; Humans; Indans; Ketanserin; Male; Mesencephalon; Mice; Mice, Inbred ICR; Nicotine; Piperidines; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serotonin Antagonists; Tourette Syndrome | 2005 |
Anticholinesterase (DFP) toxicity antagonism by chronic donepezil: a potential nerve agent treatment.
Topics: Animals; Behavior, Animal; Body Temperature; Cholinesterase Inhibitors; Diarrhea; Donepezil; Hypokinesia; Indans; Injections, Intramuscular; Injections, Intraperitoneal; Isoflurophate; Male; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors | 2005 |
Causes of syncope in patients with Alzheimer's disease treated with donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Piperidines; Syncope | 2005 |
Drug persistency of two cholinesterase inhibitors: rivastigmine versus donepezil in elderly patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Phenylcarbamates; Piperidines; Rivastigmine; Time Factors | 2005 |
Effects of selegiline alone or with donepezil on memory impairment in rats.
Topics: Analysis of Variance; Animals; Antiparkinson Agents; Aziridines; Behavior, Animal; Choline; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Escape Reaction; Fenclonine; Indans; Male; Maze Learning; Memory Disorders; Piperidines; Rats; Rats, Inbred F344; Reaction Time; Scopolamine; Selegiline; Time Factors | 2005 |
Is donepezil therapy associated with reduced mortality in nursing home residents with dementia?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cohort Studies; Cross-Sectional Studies; Databases, Factual; Dementia; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Nursing Homes; Piperidines; Proportional Hazards Models; Retrospective Studies; Tacrine | 2005 |
Treatment of progressive supranuclear palsy and corticobasal degeneration.
Topics: Amantadine; Cerebral Cortex; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dopamine Agents; Dopamine Agonists; Dystonia; Globus Pallidus; Humans; Indans; Levodopa; Nerve Degeneration; Piperidines; Substantia Nigra; Supranuclear Palsy, Progressive | 2005 |
Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease.
Topics: Aged; Alleles; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Attention; Cholinesterase Inhibitors; Cognition; Donepezil; Education; Female; Gene Frequency; Genotype; Humans; Indans; Intelligence Tests; Language; Male; Neuropsychological Tests; Piperidines; Retrospective Studies | 2005 |
When the drugs don't work.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Dementia; Donepezil; Humans; Indans; Piperidines; Treatment Failure; United Kingdom | 2005 |
Cognition-enhancing effects of donepezil in traumatic brain injury.
Topics: Adult; Brain Injuries; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Treatment Outcome | 2005 |
Angle-closure glaucoma after discontinuing donepezil hydrochloride (Aricept).
Topics: Alzheimer Disease; Donepezil; Female; Glaucoma, Angle-Closure; Humans; Indans; Middle Aged; Nootropic Agents; Piperidines | 2005 |
Impact of donepezil use in routine clinical practice on health care costs in patients with Alzheimer's disease and related dementias enrolled in a large medicare managed care plan: a case-control study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Dementia; Disease Progression; Donepezil; Drug Utilization; Female; Health Care Costs; Humans; Indans; Male; Managed Care Programs; Medicare; Piperidines | 2005 |
Vitamin E and donepezil for the treatment of mild cognitive impairment.
Topics: Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Cholinesterase Inhibitors; Data Interpretation, Statistical; Disease Progression; Donepezil; Heterozygote; Humans; Indans; Piperidines; Vitamin E | 2005 |
Evidence of acetylcholinesterase inhibitors in treating Alzheimer's disease in very old patients is uncertain.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Research Design | 2005 |
Synthesis and biological evaluation as AChE inhibitors of new indanones and thiaindanones related to donepezil.
Topics: Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Drug Design; Indans; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship | 2005 |
Unequal neuroprotection afforded by the acetylcholinesterase inhibitors galantamine, donepezil, and rivastigmine in SH-SY5Y neuroblastoma cells: role of nicotinic receptors.
Topics: Aconitine; Amyloid beta-Peptides; Apoptosis; Benzopyrans; Cell Culture Techniques; Cell Line, Tumor; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Enzyme Inhibitors; Galantamine; Humans; Indans; L-Lactate Dehydrogenase; Morpholines; Neuroblastoma; Neuroprotective Agents; Nicotine; Nitriles; Okadaic Acid; Phenylcarbamates; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-bcl-2; Receptors, Nicotinic; Rivastigmine | 2005 |
Comparison of donepezil and memantine for protective effect against amyloid-beta(1-42) toxicity in rat septal neurons.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Combinations; Indans; Memantine; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Septal Nuclei | 2005 |
A comparison of the efficacy of donepezil in Parkinson's disease with dementia and dementia with Lewy bodies.
Topics: Age Factors; Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Parkinson Disease; Piperidines; Severity of Illness Index; Treatment Outcome | 2005 |
Another data/rhetoric mismatch on donepezil.
Topics: Aged; Alzheimer Disease; Bias; Case-Control Studies; Cholinesterase Inhibitors; Donepezil; Homes for the Aged; Humans; Indans; Nursing Homes; Outcome Assessment, Health Care; Patient Admission; Piperidines; Research Design | 2005 |
UK government guidance on Alzheimer's drugs postponed.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Excitatory Amino Acid Antagonists; Federal Government; Galantamine; Government Regulation; Humans; Indans; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; United Kingdom | 2005 |
Donepezil restores GH secretion in old rats without affecting the sleep/wake cycle.
Topics: Acetylcholinesterase; Aging; Animals; Arousal; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Growth Hormone; Indans; Infusion Pumps, Implantable; Insulin-Like Growth Factor I; Male; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Sleep; Sleep, REM; Wakefulness | 2006 |
Comparison of galantamine and donepezil for effects on nerve growth factor, cholinergic markers, and memory performance in aged rats.
Topics: Acetylcholinesterase; Aging; Animals; Autoradiography; Brain; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Donepezil; Enzyme-Linked Immunosorbent Assay; Galantamine; Indans; Injections, Subcutaneous; Male; Maze Learning; Memory; Motor Activity; Nerve Growth Factor; Piperidines; Rats; Rats, Inbred F344; Receptors, Cholinergic; Vesicular Acetylcholine Transport Proteins | 2006 |
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Topics: Acetylcholinesterase; Animals; Binding Sites; Cattle; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Inhibitory Concentration 50; Models, Molecular; Molecular Structure; Piperidines; Structure-Activity Relationship; Tacrine | 2005 |
[Dementia of trisomy 21. Improvement with donepezil].
Topics: Dementia; Donepezil; Down Syndrome; Humans; Indans; Nootropic Agents; Piperidines | 2005 |
Mild cognitive impairment: to treat or not to treat.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Disease Progression; Donepezil; Humans; Indans; Piperidines | 2005 |
Rationalizing therapeutic approaches in Alzheimer's disease.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Memantine; Neuropsychological Tests; Piperidines; Receptors, N-Methyl-D-Aspartate; Severity of Illness Index | 2005 |
In vivo butyrylcholinesterase activity is not increased in Alzheimer's disease synapses.
Topics: Acetylcholinesterase; Adult; Aged; Aged, 80 and over; Alzheimer Disease; Butyrylcholinesterase; Carbon Radioisotopes; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Physostigmine; Piperidines; Positron-Emission Tomography; Reproducibility of Results; Synapses | 2006 |
Cortical activation during cholinesterase-inhibitor treatment in Alzheimer disease: preliminary findings from a pharmaco-fMRI study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain Mapping; Cerebral Cortex; Cholinesterase Inhibitors; Cognition Disorders; Dominance, Cerebral; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Face; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Memory, Short-Term; Middle Aged; Pattern Recognition, Visual; Piperidines; Prosopagnosia; Psychomotor Performance | 2005 |
Stereoselective HPLC assay of donepezil enantiomers with UV detection and its application to pharmacokinetics in rats.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2006 |
Effects of histamine H(3) antagonists and donepezil on learning and mnemonic deficits induced by pentylenetetrazol kindling in weanling mice.
Topics: Animals; Avoidance Learning; Convulsants; Donepezil; Electric Stimulation; Female; Histamine Antagonists; Indans; Kindling, Neurologic; Learning Disabilities; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Nootropic Agents; Pentylenetetrazole; Piperidines; Recognition, Psychology | 2006 |
Up-regulation of nicotinic acetylcholine receptors by central-type acetylcholinesterase inhibitors in rat cortical neurons.
Topics: Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Galantamine; Glutamic Acid; Immunoblotting; Indans; Neurons; Piperidines; Protein Subunits; Rats; Rats, Wistar; Receptors, Nicotinic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors; Up-Regulation | 2005 |
Determination of donepezil hydrochloride in human and rat plasma, blood and brain microdialysates by HPLC with a short C30 column.
Topics: Animals; Brain Chemistry; Calibration; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Male; Microdialysis; Models, Chemical; Piperidines; Rats; Rats, Wistar; Technology, Pharmaceutical; Time Factors | 2006 |
Clinical analysis of cognitive function in diabetic patients by MMSE and SPECT.
Topics: Aged; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition Disorders; Diabetes Mellitus, Type 2; Donepezil; Female; Humans; Incidence; Indans; Male; Mental Status Schedule; Piperidines; Tomography, Emission-Computed, Single-Photon | 2006 |
[Concerning the contribution by Thomas Kaiser, Christiane Florack, Heinrich Franz, Peter Sawicki: donepezil in patients with Alzheimer's dementia. The AD2000 study. Med Klin 2005;100:157-60].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Practice Guidelines as Topic | 2005 |
Alarming arbitrariness in EU prescription and reimbursement criteria for anti-dementia drugs.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Dopamine Agents; European Union; Galantamine; Humans; Indans; Memantine; Neurotransmitter Agents; Phenylcarbamates; Piperidines; Reimbursement Mechanisms; Rivastigmine | 2006 |
Effects on cholinergic markers in rat brain and blood after short and prolonged administration of donepezil.
Topics: Acetylcholine; Acetylcholinesterase; Aged; Animals; Body Temperature; Brain; Cholinesterase Inhibitors; Donepezil; Electrophoresis, Polyacrylamide Gel; Female; Humans; Indans; Male; Middle Aged; Oligonucleotide Array Sequence Analysis; Piperidines; Rats; Rats, Wistar; Receptors, Cholinergic | 2005 |
Improvement in Tc-99m HMPAO brain SPECT findings during donepezil therapy in a patient with pure akinesia.
Topics: Alexia, Pure; Brain; Cholinesterase Inhibitors; Dementia; Donepezil; Gait Disorders, Neurologic; Indans; Neurodegenerative Diseases; Piperidines; Radiopharmaceuticals; Recovery of Function; Syndrome; Technetium Tc 99m Exametazime; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2005 |
Dynamic mechanism of E2020 binding to acetylcholinesterase: a steered molecular dynamics simulation.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Computer Simulation; Donepezil; Hydrophobic and Hydrophilic Interactions; Indans; Models, Chemical; Models, Molecular; Molecular Conformation; Molecular Structure; Piperidines; Quantum Theory; Stereoisomerism | 2005 |
An open trial of adjunctive donepezil in attention-deficit/hyperactivity disorder.
Topics: Adolescent; Adult; Amphetamines; Antimanic Agents; Attention Deficit Disorder with Hyperactivity; Child; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Synergism; Drug Therapy, Combination; Female; Humans; Indans; Male; Methylphenidate; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychometrics; Treatment Outcome | 2005 |
Emergent complications following donepezil switchover to galantamine in three cases of dementia with Lewy bodies.
Topics: Aged; Cholinesterase Inhibitors; Disease Progression; Donepezil; Galantamine; Humans; Indans; Lewy Body Disease; Male; Mental Status Schedule; Neuropsychological Tests; Piperidines | 2005 |
Response to rivastigmine or donepezil in Alzheimer's patients with symptoms suggestive of concomitant Lewy body pathology.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Double-Blind Method; Female; Humans; Indans; Lewy Body Disease; Male; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Retrospective Studies; Rivastigmine; Treatment Outcome | 2006 |
Interaction with sigma(1) protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil.
Topics: Animals; Avoidance Learning; Behavior, Animal; Binding Sites; Cholinesterase Inhibitors; Cloning, Molecular; Donepezil; Ethylenediamines; Female; Indans; Ligands; Male; Maze Learning; Mice; Oligodeoxyribonucleotides, Antisense; Oocytes; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor; Swimming; Xenopus | 2006 |
Dementia with parkinsonism: what is the diagnosis?
Topics: Aged; Brain; Dementia; Diagnosis, Differential; Donepezil; Fatal Outcome; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Nootropic Agents; Parkinson Disease; Piperidines; Psychiatric Status Rating Scales | 2004 |
Protective effect of donepezil in primary-cultured rat cortical neurons exposed to N-methyl-d-aspartate (NMDA) toxicity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Indans; Kainic Acid; L-Lactate Dehydrogenase; N-Methylaspartate; Neurons; Neuroprotective Agents; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Receptors, Glutamate | 2006 |
Molecular modeling, docking and ADMET studies applied to the design of a novel hybrid for treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Models, Chemical; Models, Molecular; Molecular Structure; Piperidines; Protein Structure, Secondary; Tacrine | 2006 |
Protective effect of donepezil on retinal ganglion cells in vitro and in vivo.
Topics: Administration, Oral; Animals; Axotomy; Benzopyrans; Cell Survival; Cells, Cultured; Cholinergic Antagonists; Cholinesterase Inhibitors; Cytoprotection; Donepezil; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Glutamic Acid; Indans; Mecamylamine; Neuroprotective Agents; Nitriles; Optic Nerve Injuries; Piperidines; Rats; Retinal Ganglion Cells; Scopolamine | 2006 |
Donepezil-induced nightmares in mild cognitive impairment.
Topics: Aged; Alzheimer Disease; Cognition Disorders; Donepezil; Dreams; Female; Follow-Up Studies; Humans; Indans; Mental Status Schedule; Nootropic Agents; Piperidines | 2006 |
SPECT follow-up study of cerebral blood flow changes during Donepezil therapy in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cerebrovascular Circulation; Chi-Square Distribution; Donepezil; Female; Follow-Up Studies; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Statistics, Nonparametric; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2006 |
Donepezil treatment of topiramate-related cognitive dysfunction.
Topics: Adult; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Fructose; Humans; Indans; Language Disorders; Male; Middle Aged; Migraine Disorders; Piperidines; Topiramate; Treatment Outcome | 2006 |
[Treatment of Alzheimer's disease: clinicians's lecture].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Switzerland; Treatment Outcome | 2006 |
Effect of oral donepezil on intraocular pressure in normotensive Alzheimer patients.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Intraocular Pressure; Male; Middle Aged; Piperidines; Pupil; Treatment Outcome | 2006 |
Appeals system and its outcomes in national health insurance in Taiwan.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Middle Aged; National Health Programs; Negotiating; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; Taiwan | 2006 |
Cognitive deficits in rats after forebrain cholinergic depletion are reversed by a novel NO mimetic nitrate ester.
Topics: Acetylcholine; Analysis of Variance; Animals; Behavior, Animal; Choice Behavior; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Male; Maze Learning; Mitogen-Activated Protein Kinase 3; Nitrates; Nootropic Agents; Phosphorylation; Piperidines; Prosencephalon; Protein Binding; Psychological Tests; Rats; Rats, Long-Evans; Rats, Sprague-Dawley; Reaction Time | 2007 |
Changes in cerebral neurotransmitters and metabolites induced by acute donepezil and memantine administrations: a microdialysis study.
Topics: Acetylcholine; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Extracellular Fluid; Hippocampus; Indans; Male; Memantine; Microdialysis; Neurotransmitter Agents; Norepinephrine; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Serotonin; Temporal Lobe; Ventral Tegmental Area | 2006 |
The efficacy of donepezil hydrochloride on memory functioning in three adolescents with severe traumatic brain injury.
Topics: Adolescent; Brain Injuries; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Memory; Neuropsychological Tests; Piperidines | 2006 |
Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas.
Topics: Amnesia; Animals; Avoidance Learning; Behavior, Animal; Carbon Monoxide; Cholinesterase Inhibitors; Donepezil; Indans; Inhalation Exposure; Learning Disabilities; Male; Mice; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor | 2006 |
Correlation of visual hallucinations with occipital rCBF changes by donepezil in DLB.
Topics: Aged; Aged, 80 and over; Cerebrovascular Circulation; Donepezil; Female; Hallucinations; Humans; Indans; Lewy Body Disease; Male; Occipital Lobe; Piperidines; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon | 2006 |
Donepezil for severe Alzheimer's disease.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Long-Term Care; Patient Dropouts; Piperidines; Randomized Controlled Trials as Topic; Reproducibility of Results; Severity of Illness Index | 2006 |
Pharmacological manipulation of the vasoconstrictive effects of amyloid-beta peptides by donepezil and rivastigmine.
Topics: Amyloid beta-Peptides; Animals; Donepezil; Hindlimb; Indans; Male; Peptide Fragments; Phenylcarbamates; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine; Vasoconstriction | 2006 |
Galantamine enhances dopaminergic neurotransmission in vivo via allosteric potentiation of nicotinic acetylcholine receptors.
Topics: 2-Amino-5-phosphonovalerate; Action Potentials; Analysis of Variance; Animals; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Mecamylamine; Microdialysis; Neurons; Nicotinic Antagonists; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Synaptic Transmission; Ventral Tegmental Area | 2007 |
Neuroprotection in vascular dementia.
Topics: Animals; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Heart Diseases; Humans; Hypercholesterolemia; Hypertension; Indans; Memantine; Neuroprotective Agents; Patient Selection; Piperidines; Randomized Controlled Trials as Topic; Research Design; Risk Factors; Stroke | 2006 |
Alzheimer's drug proves risky in patients with vascular dementia.
Topics: Dementia, Vascular; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2006 |
Alzheimer's drug helps brain function after radiotherapy.
Topics: Alzheimer Disease; Brain Neoplasms; Cognition Disorders; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Radiation Injuries; Radiotherapy | 2006 |
Suppression of methamphetamine-seeking behavior by nicotinic agonists.
Topics: Acetylcholinesterase; Animals; Behavior, Animal; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Lidocaine; Male; Mecamylamine; Methamphetamine; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine | 2006 |
Dementia with mood symptoms in a fragile X premutation carrier with the fragile X-associated tremor/ataxia syndrome: clinical intervention with donepezil and venlafaxine.
Topics: Aged; Antidepressive Agents, Second-Generation; Ataxia; Atrophy; Brain; Cyclohexanols; Dementia; Dominance, Cerebral; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Fragile X Mental Retardation Protein; Fragile X Syndrome; Genetic Carrier Screening; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Mood Disorders; Neurologic Examination; Neuropsychological Tests; Nootropic Agents; Piperidines; Tremor; Trinucleotide Repeats; Venlafaxine Hydrochloride | 2006 |
Pharmacological intervention for cognitive deficits and aggression in frontal lobe injury.
Topics: Adult; Aggression; Amantadine; Cognition Disorders; Conduct Disorder; Donepezil; Frontal Lobe; Humans; Indans; Male; Neurotransmitter Agents; Nootropic Agents; Piperidines; Valproic Acid | 2006 |
Bis(7)-tacrine attenuates beta amyloid-induced neuronal apoptosis by regulating L-type calcium channels.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Embryo, Mammalian; Hippocampus; Indans; Isoflurophate; Membrane Potentials; Neurons; Nimodipine; Patch-Clamp Techniques; Peptide Fragments; Piperidines; Rats; Tacrine; Time Factors | 2006 |
[Advances in Alzheimer's disease treatment].
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Clinical Trials, Phase III as Topic; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Multicenter Studies as Topic; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Placebos; Randomized Controlled Trials as Topic; Rivastigmine | 2006 |
Comparative analysis of mortality in patients with Alzheimer's disease treated with donepezil or galantamine.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chi-Square Distribution; Cholinesterase Inhibitors; Cohort Studies; Comorbidity; Donepezil; Female; Galantamine; Humans; Indans; Male; Middle Aged; Piperidines; Retrospective Studies; Treatment Outcome | 2006 |
[Cholinesterase inhibitor therapy in long term care settings].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Follow-Up Studies; Galantamine; Humans; Indans; Long-Term Care; Neuroprotective Agents; Nootropic Agents; Patient Selection; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Time Factors | 2006 |
Pain with donepezil.
Topics: Aged, 80 and over; Alzheimer Disease; Caregivers; Donepezil; Female; Humans; Indans; Nootropic Agents; Pain; Piperidines | 2006 |
Nicotine, donepezil may dampen meth craving.
Topics: Amphetamine-Related Disorders; Animals; Central Nervous System Agents; Donepezil; Humans; Indans; Methamphetamine; Nicotine; Piperidines | 2006 |
Impact of the CYP2D6 polymorphism on steady-state plasma concentrations and clinical outcome of donepezil in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cytochrome P-450 CYP2D6; Donepezil; Female; Genotype; Humans; Indans; Male; Middle Aged; Piperidines; Polymorphism, Genetic | 2006 |
[Separation and determination of donepezil hydrochloride enantiomers in plasma by capillary electrophoresis].
Topics: Animals; beta-Cyclodextrins; Cholinesterase Inhibitors; Donepezil; Electrophoresis, Capillary; Female; Indans; Male; Piperidines; Rabbits; Stereoisomerism | 2006 |
Complete atrioventricular block and ventricular tachyarrhythmia associated with donepezil.
Topics: Aged, 80 and over; Alzheimer Disease; Cardiac Pacing, Artificial; Cholinesterase Inhibitors; Donepezil; Electrocardiography; Heart Block; Humans; Indans; Male; Piperidines; Tachycardia, Ventricular; Treatment Outcome | 2006 |
Patterns of cholinesterase-inhibitor use in the nursing home setting: a retrospective analysis.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Utilization; Female; Galantamine; Homes for the Aged; Humans; Indans; Male; Middle Aged; Nursing Homes; Phenylcarbamates; Piperidines; Polypharmacy; Retrospective Studies; Rivastigmine | 2006 |
Effects of galantamine and donepezil on active and passive avoidance tests in rats with induced hypoxia.
Topics: Animals; Avoidance Learning; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Galantamine; Hypoxia, Brain; Indans; Male; Memory; Memory Disorders; Piperidines; Rats; Rats, Wistar; Sodium Nitrite; Time Factors | 2006 |
[Risperidone and cerebrovascular adverse effects in elderly patients with dementia].
Topics: Aged; Aged, 80 and over; Antipsychotic Agents; Cerebrovascular Disorders; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Female; Galantamine; Humans; Indans; Male; Piperidines; Risperidone | 2006 |
Donepezil for severe Alzheimer's disease.
Topics: Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Cognition; Donepezil; Heart Block; Humans; Indans; Piperidines | 2006 |
Donepezil for severe Alzheimer's disease.
Topics: Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Cholinesterase Inhibitors; Donepezil; Genotype; Humans; Indans; Neuroprotective Agents; Piperidines | 2006 |
Donepezil for severe Alzheimer's disease.
Topics: Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2006 |
Pharmacological evidence of cholinergic involvement in adult hippocampal neurogenesis in rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Brain-Derived Neurotrophic Factor; Bromodeoxyuridine; Cholinergic Agents; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Immunohistochemistry; Indans; Male; Neural Inhibition; Neurons; Organogenesis; Piperidines; Rats; Rats, Sprague-Dawley; Scopolamine | 2006 |
Acetylcholinesterase inhibitor acting on the brain improves detrusor overactivity caused by cerebral infarction in rats.
Topics: Analysis of Variance; Animals; Brain; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Infarction, Middle Cerebral Artery; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors; Urinary Bladder; Urinary Bladder, Overactive | 2006 |
Comparative studies of huperzine A, donepezil, and rivastigmine on brain acetylcholine, dopamine, norepinephrine, and 5-hydroxytryptamine levels in freely-moving rats.
Topics: Acetylcholine; Administration, Oral; Alkaloids; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dopamine; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Neuroprotective Agents; Norepinephrine; Phenylcarbamates; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Rivastigmine; Serotonin; Sesquiterpenes | 2006 |
Reduced short latency afferent inhibition in patients with Down syndrome and Alzheimer-type dementia.
Topics: Adult; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Down Syndrome; Female; Humans; Indans; Male; Middle Aged; Neural Inhibition; Piperidines; Transcranial Magnetic Stimulation | 2006 |
Pharmacological characterization of orally active cholinesterase inhibitory activity of Prunus persica L. Batsch in rats.
Topics: Acetylcholinesterase; Administration, Oral; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Male; Piperidines; Plant Extracts; Prunus; Rats; Rats, Wistar; Tacrine; Tissue Extracts | 2006 |
Reduction of carry-over in column-switching HPLC/MS system with automated system washing procedure for highly sensitive direct analysis of donepezil in dog plasma.
Topics: Animals; Autoanalysis; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Dogs; Donepezil; Indans; Linear Models; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2007 |
Do lesions involving the cortical cholinergic pathways help or hinder efficacy of donepezil in patients with Alzheimer's disease?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebral Cortex; Cholinergic Fibers; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Female; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Neuropsychological Tests; Piperidines; Treatment Outcome | 2006 |
Donepezil also effective in the treatment of Tourette's syndrome?
Topics: Adolescent; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Female; Follow-Up Studies; Humans; Indans; Piperidines; Tourette Syndrome | 2006 |
Role of the cholinergic system in regulating survival of newborn neurons in the adult mouse dentate gyrus and olfactory bulb.
Topics: Acetylcholine; Animals; Animals, Newborn; Cell Survival; Cholinergic Fibers; Cholinesterase Inhibitors; Dentate Gyrus; Donepezil; Humans; Indans; Male; Mice; Mice, Inbred C57BL; Neurons; Olfactory Bulb; Piperidines; Receptors, Cholinergic | 2006 |
Donepezil primarily attenuates scopolamine-induced deficits in psychomotor function, with moderate effects on simple conditioning and attention, and small effects on working memory and spatial mapping.
Topics: Animals; Attention; Cholinesterase Inhibitors; Cognition Disorders; Conditioning, Psychological; Donepezil; Indans; Male; Maze Learning; Memory; Muscarinic Antagonists; Piperidines; Psychomotor Disorders; Rats; Rats, Sprague-Dawley; Scopolamine | 2006 |
Cognitive stimulation therapy for Alzheimer's disease: the effect of cognitive stimulation therapy on the progression of mild Alzheimer's disease in patients treated with donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Combined Modality Therapy; Disease Progression; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Severity of Illness Index | 2007 |
Stability indicating methods for determination of Donepezil Hydrochloride according to ICH guidelines.
Topics: Donepezil; Drug Stability; Guidelines as Topic; Indans; International Cooperation; Molecular Structure; Pharmaceutical Preparations; Piperidines; Sensitivity and Specificity; Spectrophotometry, Ultraviolet; Stereoisomerism | 2006 |
Rapid and sensitive determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry: application to a pharmacokinetic study.
Topics: Administration, Oral; Blood Chemical Analysis; Chromatography, Liquid; Computer Simulation; Donepezil; Humans; Indans; Metabolic Clearance Rate; Models, Biological; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization; Time Factors | 2006 |
Electroanalytical determination of donepezil HCl in tablets and human serum by differential pulse and osteryoung square wave voltammetry at a glassy carbon electrode.
Topics: Algorithms; Donepezil; Electrochemistry; Electrodes; Humans; Hydrogen-Ion Concentration; Indans; Indicators and Reagents; Nootropic Agents; Oxidation-Reduction; Pharmaceutical Solutions; Piperidines; Tablets | 2006 |
Paralytic ileus after discontinuation of cholinesterase inhibitor.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Humans; Indans; Intestinal Pseudo-Obstruction; Male; Piperidines; Withholding Treatment | 2006 |
Galantamine and donepezil attenuate pharmacologically induced deficits in prepulse inhibition in rats.
Topics: Acoustic Stimulation; Analysis of Variance; Animals; Apomorphine; Behavior, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Gait Disorders, Neurologic; Galantamine; Indans; Inhibition, Psychological; Male; Nootropic Agents; Piperidines; Rats; Reflex, Startle; Scopolamine | 2007 |
Mayo Clinic office visit. Mild cognitive impairment. An interview with Ronald Petersen, M.D., Ph.D.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Humans; Indans; Memory Disorders; Nootropic Agents; Piperidines; Treatment Failure | 2006 |
Characteristics of object location memory in mice: Behavioral and pharmacological studies.
Topics: Age Factors; Analysis of Variance; Animals; Association Learning; Behavioral Research; Cholinesterase Inhibitors; Donepezil; Exploratory Behavior; Indans; Male; Memory; Mice; Mice, Inbred ICR; Muscarinic Antagonists; Piperidines; Scopolamine; Sensitivity and Specificity; Space Perception; Spatial Behavior; Statistics, Nonparametric | 2007 |
Determination of therapeutics with growth-hormone secretagogue activity in human urine for doping control purposes.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Doping in Sports; Ethylamines; Female; Galantamine; Growth Hormone; Humans; Indans; Indoles; Phenylcarbamates; Piperidines; Rivastigmine; Spectrometry, Mass, Electrospray Ionization; Substance Abuse Detection; Tandem Mass Spectrometry; Urinalysis | 2006 |
The anti-amnesic and neuroprotective effects of donepezil against amyloid beta25-35 peptide-induced toxicity in mice involve an interaction with the sigma1 receptor.
Topics: Amnesia; Amyloid beta-Peptides; Animals; Avoidance Learning; Behavior, Animal; Donepezil; Dose-Response Relationship, Drug; Ethylenediamines; Fluorescent Dyes; Galantamine; Indans; Injections, Intraventricular; Lipid Peroxidation; Male; Maze Learning; Mice; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Phenols; Phenylcarbamates; Piperidines; Receptors, sigma; Rivastigmine; Sulfoxides; Xylenes | 2006 |
Initiation of acetylcholinesterase inhibitors and complications of chronic airways disorders in elderly patients.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Chronic Disease; Cross-Over Studies; Donepezil; Female; Galantamine; Humans; Indans; Logistic Models; Male; Phenylcarbamates; Piperidines; Respiratory Tract Diseases; Rivastigmine | 2006 |
Differential effects of donepezil on methamphetamine and cocaine dependencies.
Topics: Amphetamine-Related Disorders; Animals; Behavior, Animal; Cocaine-Related Disorders; Conditioning, Psychological; Donepezil; Indans; Male; Mice; Mice, Inbred C57BL; Motor Activity; Piperidines | 2006 |
Alcohol abuse in an elderly woman taking donepezil for Alzheimer disease.
Topics: Aged, 80 and over; Alcohol Drinking; Alcoholism; Alzheimer Disease; Cholinesterase Inhibitors; Compulsive Behavior; Donepezil; Female; Humans; Impulsive Behavior; Indans; Nootropic Agents; Piperidines | 2006 |
Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain.
Topics: Animals; Behavior, Animal; Brain; Cell Death; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Amino Acid Antagonists; Female; Indans; Memantine; Neurotoxicity Syndromes; Piperidines; Rats; Rats, Sprague-Dawley | 2008 |
Quantitative determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry employing an automated liquid-liquid extraction based on 96-well format plates. Application to a bioequivalence study.
Topics: Calibration; Cholinesterase Inhibitors; Chromatography, Liquid; Donepezil; Humans; Indans; Molecular Structure; Piperidines; Reproducibility of Results; Tandem Mass Spectrometry; Therapeutic Equivalency | 2007 |
Preclinical investigation of the functional effects of memantine and memantine combined with galantamine or donepezil.
Topics: Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Conditioning, Eyelid; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Female; Galantamine; Indans; Memantine; Nootropic Agents; Piperidines; Rabbits; Receptors, N-Methyl-D-Aspartate | 2007 |
Donepezil is a strong antagonist of voltage-gated calcium and potassium channels in molluscan neurons.
Topics: Animals; Calcium Channel Blockers; Calcium Channels; Cholinesterase Inhibitors; Donepezil; Helix, Snails; In Vitro Techniques; Indans; Neurons; Piperidines; Potassium Channel Blockers; Potassium Channels, Voltage-Gated | 2007 |
Donepezilium oxalate trihydrate, a therapeutic agent for Alzheimer's disease.
Topics: Alzheimer Disease; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Hydrogen Bonding; Indans; Molecular Structure; Piperidines; Water | 2006 |
Ginkgo biloba extract improves spatial memory in rats mainly but not exclusively via a histaminergic mechanism.
Topics: Acetylcholine; Animals; Brain; Brain Chemistry; Diphenhydramine; Donepezil; Ginkgo biloba; Histamine; Histamine H1 Antagonists; Indans; Male; Maze Learning; Memory; Memory Disorders; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Piperidines; Plant Extracts; Pyrilamine; Rats; Rats, Wistar; Scopolamine; Synaptic Transmission; Treatment Outcome | 2007 |
Researcher received undisclosed payments of 300,000 dollars from Pfizer.
Topics: Biomedical Research; Conflict of Interest; Donepezil; Drug Industry; Fees and Charges; Indans; Malpractice; Piperidines; Research Personnel; Specimen Handling; United States | 2006 |
Sensitivity of butyrylcholinesterase knockout mice to (--)-huperzine A and donepezil suggests humans with butyrylcholinesterase deficiency may not tolerate these Alzheimer's disease drugs and indicates butyrylcholinesterase function in neurotransmission.
Topics: Acetylcholine; Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Butyrylcholinesterase; Chlorpyrifos; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Mice; Mice, Knockout; Neurotoxicity Syndromes; Piperidines; Sesquiterpenes; Synaptic Transmission | 2007 |
In vitro and in vivo evaluation of donepezil-sustained release microparticles for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Capsules; Cholinesterase Inhibitors; Cognition Disorders; Delayed-Action Preparations; Diffusion; Donepezil; Drug Evaluation, Preclinical; Indans; Particle Size; Piperidines; Rats; Treatment Outcome | 2007 |
In vivo evaluation of P-glycoprotein modulation of 8 PET radioligands used clinically.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cyclosporine; Donepezil; Flumazenil; Indans; Ligands; Male; Mice; Piperidines; Positron-Emission Tomography; Radioisotopes; Sensory Receptor Cells; Verapamil; Xanthines | 2007 |
Combination of rimonabant and donepezil prolongs spatial memory duration.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Drug Combinations; Indans; Male; Maze Learning; Memory; Piperidines; Pyrazoles; Rats; Receptor, Cannabinoid, CB1; Rimonabant; Spatial Behavior; Time Factors | 2007 |
Beta2-agonists and paresthesias in multiple sclerosis.
Topics: Adrenergic beta-Agonists; Albuterol; Amantadine; Analgesics, Non-Narcotic; Androstadienes; Aromatase Inhibitors; Asthma; Bronchodilator Agents; Donepezil; Drug Therapy, Combination; Female; Fluticasone; Food Hypersensitivity; Humans; Indans; Interferons; Latex Hypersensitivity; Letrozole; Mandelic Acids; Middle Aged; Multiple Sclerosis; Nebulizers and Vaporizers; Nitriles; Nootropic Agents; Parasympatholytics; Paresthesia; Piperidines; Respiratory Function Tests; Salmeterol Xinafoate; Thyroxine; Triazoles | 2007 |
Comparative analysis of mortality in patients with Alzheimer's disease treated with donepezil and galantamine.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Nootropic Agents; Piperidines | 2007 |
Cholinesterase inhibitors in dementia with Lewy bodies: a comparative analysis.
Topics: Aged; Analysis of Variance; Cholinesterase Inhibitors; Clinical Trials as Topic; Data Interpretation, Statistical; Donepezil; Female; Galantamine; Humans; Indans; Lewy Body Disease; Male; Neuropsychological Tests; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Rivastigmine; Treatment Outcome | 2007 |
The combination of donepezil and procyclidine protects against soman-induced seizures in rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Body Temperature; Brain; Convulsants; Donepezil; Electroencephalography; Indans; Male; Muscarinic Antagonists; Nootropic Agents; Piperidines; Procyclidine; Rats; Rats, Wistar; Receptors, Cholinergic; Seizures; Soman | 2007 |
"This is the kind of information we need".
Topics: Alzheimer Disease; British Columbia; Clinical Pharmacy Information Systems; Cognition Disorders; Donepezil; Drug Utilization; Health Services Needs and Demand; Humans; Indans; Pharmacology, Clinical; Piperidines; Practice Patterns, Physicians' | 2007 |
Drug may slow brain shrinkage in pre-Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Atrophy; Brain; Cognition Disorders; Disease Progression; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2006 |
Posttraumatic stress disorder-like symptoms after treatment with acetylcholinesterase inhibitors.
Topics: Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Piperidines; Stress Disorders, Post-Traumatic; Stroke; Veterans | 2007 |
Evaluation of the slopes of cognitive impairment and disability in Alzheimer's disease (AD) patients treated with acetylcholinesterase inhibitors (AChEl).
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Diagnostic and Statistical Manual of Mental Disorders; Disability Evaluation; Donepezil; Female; Follow-Up Studies; Galantamine; Humans; Indans; Male; Mental Disorders; Neuropsychological Tests; Phenylcarbamates; Piperidines; Rivastigmine; Severity of Illness Index | 2007 |
5-HT4 receptor agonists increase sAPPalpha levels in the cortex and hippocampus of male C57BL/6j mice.
Topics: Aminobenzoates; Amyloid beta-Protein Precursor; Animals; Benzofurans; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Indoles; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; para-Aminobenzoates; Piperidines; RNA, Messenger; Serotonin 5-HT4 Receptor Agonists; Serotonin 5-HT4 Receptor Antagonists; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 2007 |
Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Blotting, Western; Donepezil; Female; Humans; Indans; Male; Piperidines | 2007 |
3DSRT evaluation of responses of Alzheimer type dementia to donepezil hydrochloride therapy.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Imaging, Three-Dimensional; Indans; Male; Piperidines; Stereotaxic Techniques; Tomography, Emission-Computed, Single-Photon | 2006 |
Interaction study of aspirin or clopidogrel on pharmacokinetics of donepezil hydrochloride in rats by HPLC-fluorescence detection.
Topics: Administration, Oral; Animals; Aspirin; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Clopidogrel; Donepezil; Drug Interactions; Fluorescence; Indans; Injections, Intraperitoneal; Male; Molecular Structure; Piperidines; Rats; Rats, Wistar; Ticlopidine | 2007 |
Donepezil in the treatment of musical hallucinations.
Topics: Aged, 80 and over; Donepezil; Drug Therapy, Combination; Female; Hallucinations; Hearing Disorders; Humans; Indans; Music; Nootropic Agents; Piperidines | 2007 |
Primary progressive aphasia.
Topics: Aphasia, Primary Progressive; Cholinesterase Inhibitors; Disease Progression; Donepezil; Humans; Indans; Memantine; Piperidines; Receptors, N-Methyl-D-Aspartate | 2007 |
Development of a liquid chromatography/tandem mass spectrometry method for the quantitation of acetylcholine and related neurotransmitters in brain microdialysis samples.
Topics: Acetylcholine; Animals; Brain Chemistry; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Data Interpretation, Statistical; Donepezil; Hippocampus; Indans; Indicators and Reagents; Male; Microdialysis; Neurotransmitter Agents; Piperidines; Rats; Receptors, Serotonin; Reference Standards; Reproducibility of Results; Serotonin Antagonists; Sodium Channel Blockers; Spectrometry, Mass, Electrospray Ionization; Stereotaxic Techniques; Sulfonamides; Tetrodotoxin; Thiophenes | 2007 |
Improvement of episodic contextual memory by S 18986 in middle-aged mice: comparison with donepezil.
Topics: Aging; Animals; Benzothiadiazines; Discrimination Learning; Donepezil; Indans; Male; Memory; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Piperidines; Receptors, AMPA; Retention, Psychology; Serial Learning | 2007 |
Donepezil induces a cholinergic sprouting in basocortical degeneration.
Topics: Acetylcholine; Alzheimer Disease; Animals; Basal Nucleus of Meynert; Cerebral Cortex; Cholinergic Fibers; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Growth Cones; Indans; Male; Nerve Degeneration; Nerve Regeneration; Neural Pathways; Neuronal Plasticity; Piperidines; Presynaptic Terminals; Rats; Rats, Sprague-Dawley; Stroke; Vesicular Acetylcholine Transport Proteins | 2007 |
Effect of anti-dementia drugs on LPS induced neuroinflammation in mice.
Topics: Acetylcholinesterase; Analysis of Variance; Animals; Brain; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Indans; Inflammation; Injections, Intraperitoneal; Interleukin-2; Lipopolysaccharides; Mice; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2007 |
NICE faces legal challenge over Alzheimer's drug.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Referral and Consultation; United Kingdom | 2007 |
Long-term cost-effectiveness of donepezil for the treatment of Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cost-Benefit Analysis; Costs and Cost Analysis; Data Interpretation, Statistical; Donepezil; Female; Germany; Health Care Costs; Health Status Indicators; Humans; Indans; Long-Term Care; Male; Markov Chains; Nootropic Agents; Patient Care Planning; Piperidines; Quality-Adjusted Life Years | 2007 |
Interaction of acetylcholinesterase inhibitor donepezil with ionic channels of the neuronal membrane.
Topics: Animals; Calcium Channels; Cell Membrane; Cholinesterase Inhibitors; Donepezil; Helix, Snails; Indans; Ion Channels; Membrane Potentials; Microelectrodes; Neurons; Patch-Clamp Techniques; Piperidines | 2006 |
Treatment of post-electroconvulsive therapy delirium and agitation with donepezil.
Topics: Aged; Cholinesterase Inhibitors; Delirium; Depressive Disorder, Major; Donepezil; Electroconvulsive Therapy; Humans; Indans; Male; Piperidines; Psychomotor Agitation | 2007 |
Oral donepezil reduces hypersensitivity after nerve injury by a spinal muscarinic receptor mechanism.
Topics: Administration, Oral; Animals; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Tolerance; Guanosine 5'-O-(3-Thiotriphosphate); Indans; Male; Pain; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; Spinal Cord | 2007 |
[Dementia with Lewy bodies. Clinical improvement under treatment with an acetylcholinesterase inhibitor].
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Hallucinations; Humans; Indans; Lewy Body Disease; Male; Mental Disorders; Piperidines; Treatment Outcome | 2007 |
Cholinesterase inhibitor treatment and urinary incontinence in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine; Urinary Incontinence | 2007 |
Cholinesterase inhibitors reduce cortical Abeta in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Amyloid beta-Peptides; Autopsy; Cerebral Cortex; Cholinesterase Inhibitors; Clinical Trials as Topic; Cohort Studies; Donepezil; Drug Evaluation; Female; Galantamine; Humans; Indans; Lewy Body Disease; Male; Middle Aged; Neuroprotective Agents; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine; Tacrine; tau Proteins; Tauopathies | 2007 |
Cost-effectiveness of memantine in moderate-to-severe Alzheimer's disease patients receiving donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Clinical Trials, Phase III as Topic; Cost-Benefit Analysis; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Memantine; Models, Econometric; Nootropic Agents; Piperidines | 2007 |
Cost-effectiveness analysis of donepezil for mild to moderate Alzheimer's disease in Taiwan.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Drug Costs; Female; Follow-Up Studies; Humans; Indans; Male; Markov Chains; Middle Aged; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Psychometrics; Quality of Life; Quality-Adjusted Life Years; Taiwan; Treatment Outcome | 2008 |
Oral gabapentin activates spinal cholinergic circuits to reduce hypersensitivity after peripheral nerve injury and interacts synergistically with oral donepezil.
Topics: Administration, Oral; Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Donepezil; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Hyperalgesia; Indans; Injections, Spinal; Male; Pain; Peripheral Nerve Injuries; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Cord | 2007 |
Impairment of nonverbal recognition in Alzheimer disease: a PET O-15 study.
Topics: Adaptation, Physiological; Aged; Alzheimer Disease; Brain Mapping; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Frontal Lobe; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Male; Memory Disorders; Middle Aged; Neuropsychological Tests; Nootropic Agents; Oxygen Radioisotopes; Pattern Recognition, Visual; Phenylcarbamates; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; Rivastigmine; Temporal Lobe | 2007 |
Donepezil in the treatment of narcolepsy.
Topics: Adult; Cataplexy; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Intracellular Signaling Peptides and Proteins; Narcolepsy; Neuropeptides; Orexins; Piperidines; Sleep, REM | 2006 |
Response to letter from Garcia and colleagues on cholinesterase inhibitors and Alzheimer's disease outcomes.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Survival Rate; Treatment Outcome | 2007 |
Effect of histamine on muscimol-induced working memory deficits in radial maze performance.
Topics: Animals; Brain Chemistry; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; GABA Agonists; GABA-A Receptor Agonists; Histamine; Histidine; Indans; Male; Maze Learning; Memory Disorders; Memory, Short-Term; Microinjections; Muscimol; Piperidines; Rats; Tacrine | 2007 |
Donepezil in Alzheimer's disease: a clinical observational study evaluating individual treatment response.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Product Surveillance, Postmarketing; Treatment Outcome | 2007 |
Do extrapyramidal features in Alzheimer patients treated with acetylcholinesterase inhibitors predict disease progression?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Disease Progression; Donepezil; Female; Humans; Indans; Male; Muscle Rigidity; New South Wales; Piperidines; United Kingdom | 2007 |
Exacerbation of myoclonus by memantine in a patient with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Donepezil; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Memantine; Myoclonus; Nootropic Agents; Piperidines | 2007 |
Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow in patients with Alzheimer's disease.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Tomography, Emission-Computed, Single-Photon | 2007 |
N1phenethyl-norcymserine, a selective butyrylcholinesterase inhibitor, increases acetylcholine release in rat cerebral cortex: a comparison with donepezil and rivastigmine.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Mass Spectrometry; Microdialysis; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine | 2007 |
The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates.
Topics: Aging; Animals; Cholinesterase Inhibitors; Computers; Conditioning, Operant; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Female; Indans; Macaca mulatta; Male; Maze Learning; Memory; Muscarinic Antagonists; Piperidines; Psychomotor Performance; Rats; Rats, Long-Evans; Rats, Wistar; Scopolamine | 2008 |
Cholinergic drugs affect novel object recognition in rats: relation with hippocampal EEG?
Topics: Animals; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Electroencephalography; Evoked Potentials, Auditory; Exploratory Behavior; Hippocampus; Indans; Male; Memory; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Scopolamine | 2007 |
Alzheimer's disease: will advances made in the past turn the tide?
Topics: Alzheimer Disease; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; History, 20th Century; History, 21st Century; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Memantine; Piperidines; Tacrine | 2007 |
Donepezil potentiates nerve growth factor-induced neurite outgrowth in PC12 cells.
Topics: Animals; Bucladesine; Cholinergic Agonists; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Extracellular Signal-Regulated MAP Kinases; Indans; Nerve Growth Factors; Neurites; PC12 Cells; Phosphorylation; Piperidines; Rats | 2007 |
Acetylcholinesterase inhibitors in assisted living: patterns of use and association with retention.
Topics: Activities of Daily Living; Aged, 80 and over; Alzheimer Disease; Assisted Living Facilities; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Administration Schedule; Female; Galantamine; Health Surveys; Homes for the Aged; Humans; Indans; Male; Mental Status Schedule; Neuropsychological Tests; Phenylcarbamates; Piperidines; Retention, Psychology; Rivastigmine; Survival Analysis; Treatment Outcome | 2008 |
Participation of cholinergic system in memory deficits induced by blockade of hippocampal mGlu(1) receptors.
Topics: Animals; Cholinergic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Hippocampus; Indans; Male; Maze Learning; Mecamylamine; Memory Disorders; Piperidines; Rats; Rats, Wistar; Receptors, Metabotropic Glutamate; Scopolamine | 2007 |
Synthesis, in vitro assay, and molecular modeling of new piperidine derivatives having dual inhibitory potency against acetylcholinesterase and Abeta1-42 aggregation for Alzheimer's disease therapeutics.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cell Line; Cell Survival; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Molecular Structure; Peptide Fragments; Piperidines; Protein Structure, Tertiary; Structure-Activity Relationship | 2007 |
Comparing treatment effects in a clinical sample of patients with probable Alzheimer's disease treated with two different cholinesterase inhibitors.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine | 2007 |
Use of serum insulin-like growth factor-I levels to predict psychiatric non-response to donepezil in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Humans; Indans; Insulin-Like Growth Factor I; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Piperidines; Treatment Failure | 2008 |
Methodological matters on an Alzheimer's dementia trial: is a double-blind randomized controlled study design sufficient to draw strong conclusions on treatment? Reply to Dr Mazza and colleagues.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Double-Blind Method; Ginkgo biloba; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 2007 |
Comments on the article by Mazza et al. concerning Ginkgo biloba and donepezil: a comparison in the treatment of Alzheimer's dementia in a randomized placebo-controlled double-blind study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Double-Blind Method; Ginkgo biloba; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 2007 |
The clinical meaningfulness of ADAS-Cog changes in Alzheimer's disease patients treated with donepezil in an open-label trial.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Severity of Illness Index; Treatment Outcome | 2007 |
Is donepezil useful for improving cognitive dysfunction in bipolar disorder?
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Bipolar Disorder; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Memory Disorders; Middle Aged; Patient Dropouts; Piperidines; Private Practice; Psychiatric Status Rating Scales; Severity of Illness Index; Treatment Outcome | 2008 |
Evaluation of centrally acting cholinesterase inhibitor exposures in adults.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Gastrointestinal Diseases; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Poison Control Centers; Retrospective Studies; Rivastigmine; Tacrine | 2007 |
The uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine prolongs spatial memory in a rat delayed radial-arm maze memory task.
Topics: Animals; Binding, Competitive; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Indans; Male; Maze Learning; Memantine; Memory; Piperidines; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Rimonabant; Space Perception | 2007 |
Calculate the QT interval in patients taking drugs for dementia.
Topics: Aged; Dementia; Donepezil; Female; Humans; Indans; Long QT Syndrome; Nootropic Agents; Piperidines; Tachycardia, Ventricular | 2007 |
[Amnesic syndrome following lesion of the fornix or does reversible Korsakow's syndrome exist?].
Topics: Amnesia, Anterograde; Citalopram; Donepezil; Female; Fornix, Brain; Humans; Indans; Intracranial Aneurysm; Korsakoff Syndrome; Middle Aged; Neurosurgical Procedures; Nootropic Agents; Piperidines; Risperidone; Rupture, Spontaneous; Subarachnoid Hemorrhage; Vasospasm, Intracranial | 2007 |
Galantamine and donepezil differently affect isolation rearing-induced deficits of prepulse inhibition in mice.
Topics: Aconitine; Acoustic Stimulation; alpha7 Nicotinic Acetylcholine Receptor; Analysis of Variance; Animals; Animals, Outbred Strains; Apomorphine; Behavior, Animal; Cholinesterase Inhibitors; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Galantamine; Indans; Male; Mecamylamine; Mice; Neural Inhibition; Nicotinic Antagonists; Piperidines; Receptors, Nicotinic; Reflex, Startle; Risperidone; Social Isolation | 2008 |
NICE judgement leaves behind a nasty taste.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Formularies as Topic; Galantamine; Humans; Indans; Insurance, Health, Reimbursement; Insurance, Pharmaceutical Services; Jurisprudence; Phenylcarbamates; Piperidines; Rivastigmine; State Medicine; Time Factors; United Kingdom | 2007 |
Treatment of neuropsychiatric symptoms in patients with dementia.
Topics: Aged; Alzheimer Disease; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Patient Selection; Piperidines; Psychomotor Agitation; Psychotherapy; Social Support; Treatment Failure | 2007 |
Some treatment dilemmas in rapidly developing dementia: a case report.
Topics: Aged; Antipsychotic Agents; Benzodiazepines; Cholinesterase Inhibitors; Dementia; Depression; Disease Progression; Donepezil; Dopamine Agonists; Drug Therapy, Combination; Electrocardiography; Electroencephalography; Humans; Indans; Male; Memantine; Neuropsychological Tests; Olanzapine; Piperidines; Severity of Illness Index | 2008 |
Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats.
Topics: Animals; Behavior, Animal; Brain; Brain Ischemia; Choline O-Acetyltransferase; Cilostazol; Cognition Disorders; CREB-Binding Protein; Donepezil; Drug Combinations; Indans; Male; Maze Learning; Neuroprotective Agents; Piperidines; Proto-Oncogene Proteins c-bcl-2; Random Allocation; Rats; Rats, Sprague-Dawley; Tetrazoles; Vesicular Acetylcholine Transport Proteins | 2007 |
alpha4beta2-nicotinic receptor binding with 5-IA in Alzheimer's disease: methods of scan analysis.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Azetidines; Brain; Cholinesterase Inhibitors; Donepezil; Female; Humans; Image Processing, Computer-Assisted; Indans; Male; Neuropsychological Tests; Nootropic Agents; Observer Variation; Pilot Projects; Piperidines; Pyridines; Radiopharmaceuticals; Receptors, Nicotinic; Tomography, Emission-Computed, Single-Photon | 2008 |
Intraoperative floppy-iris syndrome associated with chronic intake of donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Intraoperative Complications; Iris Diseases; Male; Phacoemulsification; Piperidines; Syndrome | 2007 |
Drug interactions with cholinesterase inhibitors: an analysis of the French pharmacovigilance database and a comparison of two national drug formularies (Vidal, British National Formulary).
Topics: Adult; Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Databases, Factual; Donepezil; Drug Interactions; Female; Formularies as Topic; France; Galantamine; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine; United Kingdom | 2007 |
Donepezil treatment and Alzheimer disease: can the results of randomized clinical trials be applied to Alzheimer disease patients in clinical practice?
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; California; Cholinesterase Inhibitors; Clinical Protocols; Donepezil; Drug Prescriptions; Drug Utilization; Female; Follow-Up Studies; Humans; Indans; Longitudinal Studies; Male; Middle Aged; Multicenter Studies as Topic; Piperidines; Practice Patterns, Physicians'; Prospective Studies; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Treatment Outcome | 2007 |
Donepezil-induced chorea in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Chorea; Donepezil; Humans; Indans; Magnetic Resonance Imaging; Male; Piperidines; Tomography, Emission-Computed, Single-Photon | 2007 |
Development and characterization of beta-secretase monolithic micro-immobilized enzyme reactor for on-line high-performance liquid chromatography studies.
Topics: Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Caseins; Chromatography, High Pressure Liquid; Donepezil; Enzymes, Immobilized; Indans; Pepstatins; Piperidines; Spectrometry, Mass, Electrospray Ionization | 2007 |
NICE on dementia: Omitting donepezil is hardly a hardship.
Topics: Dementia; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Prejudice; Randomized Controlled Trials as Topic | 2007 |
Camptocormia in Alzheimer's disease: an association?
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Piperidines; Posture; Sleep Apnea Syndromes; Videotape Recording | 2008 |
Cognitive evaluation of disease-modifying efficacy of donepezil in the APP23 mouse model for Alzheimer's disease.
Topics: Amyloid beta-Protein Precursor; Animals; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Escape Reaction; Genotype; Indans; Infusion Pumps, Implantable; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Mice, Transgenic; Nootropic Agents; Orientation; Piperidines; Reaction Time; Retention, Psychology; Treatment Outcome | 2008 |
Prucalopride and donepezil act synergistically to reverse scopolamine-induced memory deficit in C57Bl/6j mice.
Topics: Amyloid beta-Protein Precursor; Analysis of Variance; Aniline Compounds; Animals; Benzofurans; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Hippocampus; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Motor Activity; Nootropic Agents; Piperidines; Scopolamine; Serotonin 5-HT4 Receptor Agonists; Statistics, Nonparametric | 2008 |
In vivo visualization of donepezil binding in the brain of patients with Alzheimer's disease.
Topics: Acetylcholinesterase; Administration, Oral; Aged; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Piperidines; Positron-Emission Tomography; Reproducibility of Results; Temporal Lobe; Treatment Outcome | 2008 |
Risperidone, olanzapine and quetiapine in the treatment of behavioral and psychological symptoms in patients with Alzheimer's disease: preliminary findings from a naturalistic, retrospective study.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Antipsychotic Agents; Behavior; Benzodiazepines; Cognition; Data Interpretation, Statistical; Dibenzothiazepines; Donepezil; Endpoint Determination; Female; Galantamine; Humans; Indans; Long-Term Care; Male; Neuropsychological Tests; Nootropic Agents; Olanzapine; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Quetiapine Fumarate; Retrospective Studies; Risperidone; Rivastigmine; Treatment Outcome | 2007 |
Spatial memory impairment without apoptosis induced by the combination of beta-amyloid oligomers and cerebral ischemia is related to decreased acetylcholine release in rats.
Topics: Acetylcholine; Amyloid beta-Peptides; Animals; Apoptosis; Behavior, Animal; Brain Ischemia; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Down-Regulation; Hippocampus; In Situ Nick-End Labeling; Indans; Male; Maze Learning; Memory Disorders; Microdialysis; Peptide Fragments; Piperidines; Potassium; Rats; Rats, Wistar; Space Perception | 2008 |
New gradient high-performance liquid chromatography method for determination of donepezil hydrochloride assay and impurities content in oral pharmaceutical formulation.
Topics: Administration, Oral; Chromatography, High Pressure Liquid; Donepezil; Drug Contamination; Indans; Pharmaceutical Preparations; Piperidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization | 2008 |
Modulation of celecoxib- and streptozotocin-induced experimental dementia of Alzheimer's disease by pitavastatin and donepezil.
Topics: Acetylcholinesterase; Administration, Oral; Alzheimer Disease; Animals; Brain; Celecoxib; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Escape Reaction; Female; Glutathione; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indans; Injections, Intraventricular; Male; Maze Learning; Mental Recall; Mice; Nootropic Agents; Piperidines; Pyrazoles; Quinolines; Streptozocin; Sulfonamides; Thiobarbituric Acid Reactive Substances | 2008 |
Neuroleptic malignant syndrome variant in a patient receiving donepezil and olanzapine.
Topics: Aged; Benzodiazepines; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Neuroleptic Malignant Syndrome; Olanzapine; Piperidines; Selective Serotonin Reuptake Inhibitors | 2008 |
Chronic pentylenetetrazole but not donepezil treatment rescues spatial cognition in Ts65Dn mice, a model for Down syndrome.
Topics: Acetylcholine; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Disease Models, Animal; Donepezil; Down Syndrome; Drug Administration Schedule; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Neurologic Mutants; Neural Inhibition; Pentylenetetrazole; Piperidines; Receptors, GABA-A; Treatment Outcome; Trisomy | 2008 |
Effect of donepezil and tacrine on oxidative stress in intracerebral streptozotocin-induced model of dementia in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia; Disease Models, Animal; Donepezil; Glutathione; Indans; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mice; Nootropic Agents; Oxidative Stress; Piperidines; Streptozocin; Tacrine | 2008 |
For debate: is the evidence for the efficacy of cholinesterase inhibitors in the symptomatic treatment of Alzheimer's disease convincing or not?
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Galantamine; Humans; Indans; Neuropsychological Tests; Piperidines; Severity of Illness Index; Treatment Outcome | 2008 |
Comparative effects of the alpha7 nicotinic partial agonist, S 24795, and the cholinesterase inhibitor, donepezil, against aging-related deficits in declarative and working memory in mice.
Topics: Aging; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Animals; Choice Behavior; Cholinesterase Inhibitors; Discrimination Learning; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Indans; Inhibition, Psychological; Injections, Subcutaneous; Maze Learning; Memory, Short-Term; Mice; Mice, Inbred C57BL; Nicotinic Agonists; Nootropic Agents; Piperidines; Pyridinium Compounds; Receptors, Nicotinic; Retention, Psychology | 2008 |
Does donepezil improve executive function in patients with CADASIL?
Topics: CADASIL; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Problem Solving | 2008 |
Use of donepezil in the treatment of cognitive impairments of moderate traumatic brain injury.
Topics: Brain Injuries; Cognition Disorders; Donepezil; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2008 |
Donepezil induced hypomania.
Topics: Bipolar Disorder; Donepezil; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2008 |
Cognitive performance of healthy young rats following chronic donepezil administration.
Topics: Animals; Arousal; Avoidance Learning; Behavior, Animal; Choice Behavior; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Escape Reaction; Indans; Male; Maze Learning; Mental Recall; Motivation; Motor Activity; Nootropic Agents; Orientation; Piperidines; Rats; Rats, Wistar; Reaction Time; Serial Learning | 2008 |
Summaries for patients. Drug treatment for patients with dementia: American College of Physicians and American Academy of Family Physicians recommendations.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine | 2008 |
Current pharmacologic treatment of dementia: a clinical practice guideline from the American College of Physicians and the American Academy of Family Physicians.
Topics: Activities of Daily Living; Affect; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Excitatory Amino Acid Antagonists; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Quality of Life; Rivastigmine; Tacrine | 2008 |
Donepezil-induced jaw tremor.
Topics: Aged; Donepezil; Female; Humans; Indans; Jaw; Memory Disorders; Neuropsychological Tests; Nootropic Agents; Piperidines; Severity of Illness Index; Tremor | 2008 |
Effect of insulin and melatonin on acetylcholinesterase activity in the brain of amnesic mice.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Brain; Cholinergic Fibers; Donepezil; Hypoglycemic Agents; Indans; Insulin; Male; Melatonin; Mice; Motor Activity; Nootropic Agents; Piperidines; Reaction Time; Scopolamine; Transfer, Psychology | 2008 |
Discontinuation of donepezil for the treatment of Alzheimer's disease in geriatric practice.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Japan; Kaplan-Meier Estimate; Long-Term Care; Male; Neuropsychological Tests; Piperidines; Psychometrics; Retrospective Studies; Treatment Outcome | 2008 |
Exploitation of HIV protease inhibitor Indinavir as a memory restorative agent in experimental dementia.
Topics: Acetylcholinesterase; Animals; Antibiotics, Antineoplastic; Brain; Celecoxib; Cyclooxygenase Inhibitors; Dementia; Donepezil; Female; Glutathione; HIV Protease Inhibitors; Indans; Indinavir; Male; Maze Learning; Memory; Memory Disorders; Mice; Nootropic Agents; Oxidative Stress; Piperidines; Pyrazoles; Streptozocin; Sulfonamides; Thiobarbituric Acid Reactive Substances | 2008 |
Adjunctive galantamine, but not donepezil, enhances the antipsychotic-like effect of raclopride in rats.
Topics: Animals; Antipsychotic Agents; Avoidance Learning; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Psychological; Donepezil; Dose-Response Relationship, Drug; Drug Combinations; Freezing Reaction, Cataleptic; Galantamine; Indans; Male; Piperidines; Raclopride; Rats; Rats, Wistar | 2008 |
Neuroprotective and antiamnesic effect of donepezil, a nicotinic acetylcholine-receptor activator, on rats with concussive mild traumatic brain injury.
Topics: Animals; Brain; Brain Concussion; Brain Injuries; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Hippocampus; Indans; Male; Maze Learning; Memory Disorders; Nerve Degeneration; Neuroprotective Agents; Nicotinic Agonists; Nicotinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Treatment Outcome | 2008 |
Synergistic effects of selegiline and donepezil on cognitive impairment induced by amyloid beta (25-35).
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Association Learning; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Indans; Male; Maze Learning; Mice; Mice, Inbred ICR; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Piperidines; Recognition, Psychology; Selegiline; Single-Blind Method; Statistics, Nonparametric | 2008 |
Estimated pre-morbid IQ effects on cognitive and functional outcomes in Alzheimer disease: a longitudinal study in a treated cohort.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cognition; Donepezil; Female; Follow-Up Studies; Humans; Indans; Intelligence; Intelligence Tests; Learning; Longitudinal Studies; Male; Neuroprotective Agents; Nootropic Agents; Patient Compliance; Phenylcarbamates; Piperidines; Prognosis; Reading; Rivastigmine; Self Care; Speech | 2008 |
Antagonism of morphine-induced central respiratory depression by donepezil in the anesthetized rabbit.
Topics: Animals; Cholinesterase Inhibitors; Depression, Chemical; Donepezil; Indans; Male; Morphine; Phrenic Nerve; Piperidines; Rabbits; Respiration | 2007 |
Dementia medications in palliative care #174.
Topics: Antiparkinson Agents; Cholinesterase Inhibitors; Dementia; Disease Progression; Donepezil; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Nootropic Agents; Palliative Care; Phenylcarbamates; Piperidines; Prognosis; Receptors, N-Methyl-D-Aspartate; Rivastigmine | 2008 |
AAFP and ACP release guideline on dementia treatment.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Guidelines as Topic; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine; Tacrine | 2008 |
Neuroleptic malignant syndrome and catatonia in a patient with dementia.
Topics: Aged; Anti-Anxiety Agents; Antipsychotic Agents; Benzodiazepines; Catatonia; Chlorpromazine; Cholinesterase Inhibitors; Cognition Disorders; Creatine Kinase; Dementia; Disease Progression; Donepezil; Female; Humans; Indans; Lorazepam; Muscle Rigidity; Neuroleptic Malignant Syndrome; Olanzapine; Piperidines; Recurrence; Risperidone | 2008 |
Donepezil, an acetylcholinesterase inhibitor, enhances adult hippocampal neurogenesis.
Topics: Acetylcholinesterase; Animals; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Donepezil; Hippocampus; Immunohistochemistry; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley | 2008 |
Controlled release of donepezil intercalated in smectite clays.
Topics: Acrylates; Adsorption; Aluminum Silicates; Bentonite; Cholinesterase Inhibitors; Delayed-Action Preparations; Donepezil; Drug Carriers; Drug Delivery Systems; Indans; Piperidines; Polymers; Powder Diffraction; Silicates; Spectroscopy, Fourier Transform Infrared; Thermogravimetry; Time Factors | 2008 |
Donepezil attenuates excitotoxic damage induced by membrane depolarization of cortical neurons exposed to veratridine.
Topics: Animals; Calcium; Caspase Inhibitors; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Glutamic Acid; Glycine; Indans; Membrane Potentials; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Sodium; Tetrodotoxin; Veratridine | 2008 |
Prevalence of cholinesterase inhibitors in subjects with dementia in Europe.
Topics: Cholinesterase Inhibitors; Dementia; Donepezil; Europe; Galantamine; Health Policy; Humans; Indans; Insurance, Health, Reimbursement; Phenylcarbamates; Piperidines; Practice Patterns, Physicians'; Prevalence; Rivastigmine | 2008 |
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cattle; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Structure-Activity Relationship; Tacrine | 2008 |
An odd manifestation of the Capgras syndrome: loss of familiarity even with the sexual partner.
Topics: Aged; Amnesia; Antipsychotic Agents; Atrophy; Brain; Capgras Syndrome; Donepezil; Hallucinations; Humans; Indans; Male; Memory; Movement Disorders; Neuropsychological Tests; Nootropic Agents; Parkinsonian Disorders; Piperidines; Recognition, Psychology; Risperidone; Sexual Behavior; Spouses; Tomography, Emission-Computed, Single-Photon; Tomography, X-Ray Computed | 2008 |
Study of neuroprotection of donepezil, a therapy for Alzheimer's disease.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; In Vitro Techniques; Indans; N-Methylaspartate; Neuroprotective Agents; Piperidines; Rats; Rats, Wistar | 2008 |
The new approach in development of anti-Alzheimer's disease drugs via the cholinergic hypothesis.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Drug Design; Humans; Indans; Neuroprotective Agents; Piperidines; Structure-Activity Relationship | 2008 |
Cholinesterase inhibitor donepezil dilates cerebral parenchymal arterioles via the activation of neuronal nitric oxide synthase.
Topics: Animals; Arterioles; Brain; Cholinesterase Inhibitors; Donepezil; Enzyme Activation; Indans; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Nitric Oxide Synthase Type I; Piperidines; Rats; Rats, Wistar; Vasodilation | 2008 |
Mechanisms of alpha7-nicotinic receptor up-regulation and sensitization to donepezil induced by chronic donepezil treatment.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Cells, Cultured; Donepezil; Flavonoids; Indans; MAP Kinase Signaling System; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Signal Transduction; Up-Regulation | 2008 |
Prolonged treatment with donepezil increases acetylcholinesterase expression in the central nervous system.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Autoradiography; Cholinesterase Inhibitors; Densitometry; Donepezil; Gene Expression Regulation, Enzymologic; Hippocampus; Image Processing, Computer-Assisted; In Situ Hybridization; Indans; Injections, Subcutaneous; Long-Term Care; Male; Piperidines; Rats; Rats, Wistar; RNA, Messenger | 2008 |
Comparison of cholinesterase inhibitor utilization patterns and associated health care costs in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Databases, Factual; Donepezil; Drug Costs; Female; Follow-Up Studies; Galantamine; Health Care Costs; Humans; Indans; Male; Multivariate Analysis; Patient Compliance; Phenylcarbamates; Piperidines; Practice Patterns, Physicians'; Retrospective Studies; Rivastigmine | 2008 |
Clinical and therapeutic aspects of vascular dementia.
Topics: Brain; Dementia, Vascular; Diagnostic Imaging; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic | 2008 |
Commentary on "the Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics".
Topics: Alzheimer Disease; Anticholesteremic Agents; Atorvastatin; Cholinesterase Inhibitors; Donepezil; Drug Therapy, Combination; Heptanoic Acids; Humans; Indans; Multicenter Studies as Topic; Piperidines; Pyrroles; Randomized Controlled Trials as Topic | 2008 |
The effect of donepezil on increased regional cerebral blood flow in the posterior cingulate cortex of a patient with Parkinson's disease dementia.
Topics: Aged; Cerebrovascular Circulation; Dementia; Donepezil; Gyrus Cinguli; Humans; Indans; Male; Mental Status Schedule; Neuropsychological Tests; Nootropic Agents; Parkinson Disease; Piperidines; Regional Blood Flow; Treatment Outcome | 2008 |
Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors.
Topics: Analysis of Variance; Animals; Anisoles; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Indans; Inositol 1,4,5-Trisphosphate Receptors; Macrocyclic Compounds; Microtubule-Associated Proteins; Nerve Growth Factor; Neurites; Oxazoles; PC12 Cells; Physostigmine; Piperidines; Propylamines; Rats; Receptors, sigma; Sigma-1 Receptor | 2008 |
Mechanism of neuroprotection by donepezil pretreatment in rat cortical neurons chronically treated with donepezil.
Topics: Animals; Apoptosis; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Cytoprotection; Donepezil; Enzyme Inhibitors; Glutamic Acid; Indans; Ionomycin; Ionophores; MAP Kinase Signaling System; Necrosis; Nerve Degeneration; Neurons; Neuroprotective Agents; Nicotinic Antagonists; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Nicotinic; Signal Transduction | 2008 |
Comparison of hydrophilic interaction and reversed-phase liquid chromatography coupled with tandem mass spectrometric detection for the determination of three pharmaceuticals in human plasma.
Topics: Cetirizine; Chromatography, Liquid; Donepezil; Humans; Indans; Loratadine; Piperidines; Reproducibility of Results; Tandem Mass Spectrometry | 2008 |
Effect of donepezil on innate antiviral immunity of human leukocytes.
Topics: Adult; Aged; Alzheimer Disease; Analysis of Variance; Animals; Cell Line, Transformed; Cholinesterase Inhibitors; Cytokines; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Immunity, Innate; Indans; Leukocyte Count; Leukocytes; Male; Mice; Middle Aged; NF-kappa B; Piperidines; Vesicular stomatitis Indiana virus | 2008 |
Defining treatment response to donepezil in Alzheimer's disease: responder analysis of patient-level data from randomized, placebo-controlled studies.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Humans; Indans; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Treatment Outcome | 2008 |
Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro.
Topics: Animals; Brain; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Galantamine; In Vitro Techniques; Indans; Male; Neurons; PC12 Cells; Phenylcarbamates; Piperidines; Protein Binding; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Rivastigmine | 2008 |
Variability of AChE, BChE, and ChAT genes in the late-onset form of Alzheimer's disease and relationships with response to treatment with Donepezil and Rivastigmine.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Butyrylcholinesterase; Case-Control Studies; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Donepezil; Female; Gene Frequency; Genotype; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Polymorphism, Single Nucleotide; Rivastigmine | 2009 |
[Alzheimer type dementia].
Topics: Alzheimer Disease; Apolipoprotein E4; Diagnosis, Differential; Disease Progression; Donepezil; Humans; Indans; Memantine; Neuroprotective Agents; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Risk Factors; Rivastigmine | 2008 |
Sensitive analysis of donepezil in plasma by capillary electrophoresis combining on-column field-amplified sample stacking and its application in Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Middle Aged; Nootropic Agents; Piperidines; Sensitivity and Specificity | 2008 |
Hydrophilic interaction chromatography-tandem mass spectrometry of donepezil in human plasma: application to a pharmacokinetic study of donepezil in volunteers.
Topics: Adult; Calibration; Chromatography, Liquid; Donepezil; Drug Stability; Freezing; Humans; Indans; Indicators and Reagents; Male; Nootropic Agents; Piperidines; Quality Control; Reference Standards; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2008 |
Concurrent use of anticholinergic drugs and cholinesterase inhibitors: register-based study of over 700,000 elderly patients.
Topics: Aged; Aged, 80 and over; Cholinergic Antagonists; Cholinesterase Inhibitors; Data Collection; Donepezil; Drug Therapy, Combination; Female; Health Services for the Aged; Humans; Hydroxyzine; Indans; Logistic Models; Male; Monoamine Oxidase Inhibitors; Parasympatholytics; Patients; Piperidines; Registries; Rural Population; Sweden; Urban Population; Urinary Tract | 2008 |
Randomized clinical trial results for donepezil in Alzheimer's disease: is the treatment glass half full or half empty?
Topics: Activities of Daily Living; Advertising; Aged; Alzheimer Disease; Conflict of Interest; Donepezil; Double-Blind Method; Drug Industry; Economic Competition; Evidence-Based Medicine; Humans; Indans; Marketing; Nootropic Agents; Piperidines; Randomized Controlled Trials as Topic; Treatment Outcome | 2008 |
Effect of citalopram in treating hypersexuality in an Alzheimer's disease case.
Topics: Alzheimer Disease; Brain; Citalopram; Cognition Disorders; Disease Progression; Donepezil; Fluorodeoxyglucose F18; Humans; Indans; Male; Memory Disorders; Middle Aged; Mood Disorders; Nootropic Agents; Obsessive-Compulsive Disorder; Piperidines; Positron-Emission Tomography; Selective Serotonin Reuptake Inhibitors; Serotonin; Sexual Behavior; Sexual Dysfunctions, Psychological; Treatment Outcome | 2008 |
The binding of donepezil with external mouth of K+-channels of molluscan neurons.
Topics: Animals; Binding, Competitive; Calcium Signaling; Cell Membrane; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Ganglia, Invertebrate; Indans; Ion Channel Gating; Membrane Potentials; Neurons; Patch-Clamp Techniques; Piperidines; Potassium Channel Blockers; Potassium Channels; Snails; Tetraethylammonium | 2009 |
Synthesis and biological evaluation of new donepezil-like Thiaindanones as AChE inhibitors.
Topics: Acetamides; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Inhibitory Concentration 50; Piperidines; Structure-Activity Relationship | 2008 |
Multiplicative interactions to enhance gabapentin to treat neuropathic pain.
Topics: Amines; Analgesics; Animals; Cyclohexanecarboxylic Acids; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Duloxetine Hydrochloride; Gabapentin; gamma-Aminobutyric Acid; Indans; Injections, Spinal; Ligation; Male; Neurotransmitter Uptake Inhibitors; Nootropic Agents; Pain; Pain Measurement; Peripheral Nervous System Diseases; Physical Stimulation; Piperidines; Postural Balance; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Spinal Nerves; Thiophenes | 2008 |
[Familial Alzheimer's disease with presenilin 2 N141I mutation. A case report].
Topics: Adult; Alzheimer Disease; Antidepressive Agents, Second-Generation; Brain; Citalopram; Codon; Donepezil; Electroencephalography; Female; Fluorodeoxyglucose F18; Humans; Indans; Mutation, Missense; Neuropsychological Tests; Nootropic Agents; Pedigree; Piperidines; Positron-Emission Tomography; Presenilin-2; Radiopharmaceuticals | 2008 |
Quantitation of donepezil and its active metabolite 6-O-desmethyl donepezil in human plasma by a selective and sensitive liquid chromatography-tandem mass spectrometric method.
Topics: Adult; Chromatography, Liquid; Donepezil; Fasting; Humans; Indans; Linear Models; Male; Piperidines; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Tandem Mass Spectrometry; Therapeutic Equivalency; Time Factors | 2008 |
Early postnatal maternal deprivation in rats induces memory deficits in adult life that can be reversed by donepezil and galantamine.
Topics: Acetylcholine; Acetylcholinesterase; Aging; Animals; Animals, Newborn; Brain; Disease Models, Animal; Donepezil; Female; Galantamine; Hippocampus; Indans; Learning Disabilities; Male; Maternal Deprivation; Memory Disorders; Neuropsychological Tests; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Social Behavior | 2009 |
Drug utilization review of cholinesterase inhibitors in Quebec.
Topics: Adult; Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Utilization Review; Galantamine; Humans; Indans; Middle Aged; Phenylcarbamates; Piperidines; Quebec; Rivastigmine | 2008 |
Donepezil treatment of severe Alzheimer's disease in nursing home settings. A responder analysis.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Behavior; Body Mass Index; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Nursing Homes; Piperidines; Treatment Outcome | 2008 |
Effectiveness and safety of donepezil in Hispanic patients with Alzheimer's disease: a 12-week open-label study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Hispanic or Latino; Humans; Indans; Male; Middle Aged; Piperidines | 2008 |
SPECT-identified neuroanatomical predictor of the cognitive effects of donepezil treatment in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cognition; Donepezil; Female; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Predictive Value of Tests; Tomography, Emission-Computed, Single-Photon | 2008 |
Plasma urate and progression of mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Boston; Cognition Disorders; Confounding Factors, Epidemiologic; Dementia; Disease Progression; Donepezil; Female; Humans; Incidence; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Prevalence; Survival Analysis; Uric Acid; Vitamin E | 2009 |
Neuroprotective effects of donepezil through inhibition of GSK-3 activity in amyloid-beta-induced neuronal cell death.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Apoptosis; Cell Survival; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Chromones; Donepezil; Dose-Response Relationship, Drug; Embryo, Mammalian; Glycogen Synthase Kinase 3; Indans; Indoles; Mecamylamine; Morpholines; Neurons; Neuroprotective Agents; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Peptide Fragments; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Serine; Sincalide | 2009 |
Galantamine improves apomorphine-induced deficits in prepulse inhibition via muscarinic ACh receptors in mice.
Topics: Acetylcholine; Acoustic Stimulation; Animals; Animals, Outbred Strains; Apomorphine; Behavior, Animal; Benzazepines; Cholinesterase Inhibitors; Donepezil; Dopamine; Dopamine Agonists; Dopamine Antagonists; Dose-Response Relationship, Drug; Drug Interactions; Galantamine; Indans; Inhibition, Psychological; Male; Mecamylamine; Mice; Microdialysis; Muscarinic Agonists; Muscarinic Antagonists; Nicotinic Antagonists; Oxotremorine; Piperidines; Pirenzepine; Prefrontal Cortex; Receptors, Muscarinic; Reflex, Startle; Serotonin | 2009 |
Possible Alzheimer's disease in an apolipoprotein E2 homozygote.
Topics: Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Donepezil; Female; Homozygote; Humans; Indans; Magnetic Resonance Imaging; Memory; Neurologic Examination; Neuropsychological Tests; Nootropic Agents; Piperidines; Positron-Emission Tomography; Tomography, X-Ray Computed | 2009 |
The impact of Alzheimer's disease medication on muscle relaxants.
Topics: Alzheimer Disease; Androstanols; Cholinesterase Inhibitors; Donepezil; Drug Interactions; gamma-Cyclodextrins; Humans; Indans; Neuromuscular Depolarizing Agents; Neuromuscular Nondepolarizing Agents; Piperidines; Rocuronium; Succinylcholine; Sugammadex | 2009 |
Cracking the therapeutic nut in mild cognitive impairment: better nuts and better nutcrackers.
Topics: Alzheimer Disease; Biomarkers; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Disease Progression; Donepezil; Humans; Indans; Neuropsychological Tests; Outcome Assessment, Health Care; Piperidines; Research Design; Treatment Failure | 2009 |
Successful use of donepezil in treatment of cognitive impairment caused by maintenance electroconvulsive therapy: a case report.
Topics: Adult; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Electroconvulsive Therapy; Female; Humans; Indans; Memory Disorders; Neuropsychological Tests; Nootropic Agents; Piperidines; Schizophrenia | 2009 |
Can cognitive enhancers reduce the risk of falls in people with dementia? An open-label study with controls.
Topics: Accidental Falls; Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Gait; Humans; Indans; Male; Piperidines | 2009 |
Adherence to cholinesterase inhibitors in patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Humans; Indans; Male; Medication Adherence; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine | 2009 |
Acteylcholinesterase inhibitor rivastigmine enhances cellular defenses in neuronal and macrophage-like cell lines.
Topics: Acetylcholinesterase; Cell Line; Cholinesterase Inhibitors; DNA; DNA-Binding Proteins; Donepezil; Galantamine; Gene Expression Regulation; Heat Shock Transcription Factors; Heat-Shock Response; HSP70 Heat-Shock Proteins; Humans; Indans; Macrophages; Neurons; Phenylcarbamates; Phosphorylation; Piperidines; Protein Binding; Regulatory Sequences, Nucleic Acid; Rivastigmine; RNA, Messenger; Time Factors; Transcription Factors | 2009 |
Cognitive performances of cholinergically depleted rats following chronic donepezil administration.
Topics: Acetylcholine; Analysis of Variance; Animals; Antibodies, Monoclonal; Behavior, Animal; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Exploratory Behavior; Indans; Male; Maze Learning; Neurologic Examination; Piperidines; Rats; Rats, Wistar; Ribosome Inactivating Proteins, Type 1; Saporins; Serial Learning | 2009 |
Cost-effectiveness of donepezil in the treatment of mild or moderate Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Disease Progression; Donepezil; Humans; Indans; Markov Chains; Piperidines; Quality of Life; Sensitivity and Specificity; Spain; Treatment Outcome | 2009 |
Improvements in limb kinetic apraxia by repetition of a newly designed facilitation exercise in a patient with corticobasal degeneration.
Topics: Activities of Daily Living; Apraxia, Ideomotor; Cholinesterase Inhibitors; Disease Progression; Donepezil; Female; Frontal Lobe; Hand; Humans; Indans; Middle Aged; Muscle Stretching Exercises; Neurodegenerative Diseases; Neurologic Examination; Parkinsonian Disorders; Piperidines; Recovery of Function | 2009 |
Inhibitory potency of choline esterase inhibitors on acetylcholine release and choline esterase activity in fresh specimens of human and rat neocortex.
Topics: Acetylcholine; Adolescent; Adult; Aged; Animals; Child; Child, Preschool; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Galantamine; Humans; In Vitro Techniques; Indans; Middle Aged; Neocortex; Phenylcarbamates; Physostigmine; Piperidines; Rats; Rats, Wistar; Rivastigmine; Tacrine; Young Adult | 2009 |
Donepezil treatment restores the ability of estradiol to enhance cognitive performance in aged rats: evidence for the cholinergic basis of the critical period hypothesis.
Topics: Aging; Animals; Brain; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Cognition; Conditioning, Operant; Donepezil; Estradiol; Estrogens; Female; Indans; Maze Learning; Ovariectomy; Piperidines; Rats; Rats, Sprague-Dawley; Reaction Time; Time Factors | 2009 |
Characteristic effects of anti-dementia drugs on rat sleep patterns.
Topics: Animals; Dementia; Donepezil; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Excitatory Amino Acid Antagonists; Galantamine; Indans; Male; Memantine; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Sleep; Sleep Wake Disorders; Sleep, REM | 2009 |
Donepezil improves cognitive function in mice by increasing the production of insulin-like growth factor-I in the hippocampus.
Topics: Animals; Cells, Cultured; Cognition; Donepezil; Hippocampus; Humans; Indans; Insulin-Like Growth Factor I; Male; Maze Learning; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Piperidines | 2009 |
[Effects of anti-dementia drugs on sleep-wake patterns in sleep-disturbed rats].
Topics: Animals; Donepezil; Galantamine; Indans; Male; Nootropic Agents; Piperidines; Piracetam; Rats; Rats, Wistar; Sleep; Sleep Wake Disorders; Wakefulness | 2009 |
JNJ-10181457, a selective non-imidazole histamine H(3) receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition.
Topics: Acetylcholine; Animals; Anticonvulsants; Brain; Cholinesterase Inhibitors; Cognition; Conditioning, Operant; Donepezil; Drinking Behavior; Drug Evaluation, Preclinical; Histamine Agonists; Histamine Antagonists; Imidazoles; Indans; Learning; Microdialysis; Morpholines; Muscarinic Antagonists; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Histamine H3; Scopolamine; Synaptic Transmission; Thiourea | 2009 |
In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.
Topics: Amyloid beta-Protein Precursor; Animals; Brain; Choline; Cholinesterase Inhibitors; Corpus Striatum; Creatine; Donepezil; Enzyme-Linked Immunosorbent Assay; Female; Frontal Lobe; Glutamic Acid; Hippocampus; Humans; Indans; Injections, Intraperitoneal; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred C57BL; Mice, Transgenic; Multivariate Analysis; Mutation; Parietal Lobe; Piperidines; Presenilin-1; Taurine | 2009 |
GEPT extract reduces Abeta deposition by regulating the balance between production and degradation of Abeta in APPV717I transgenic mice.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Analysis of Variance; Animals; Aspartic Acid Endopeptidases; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Drugs, Chinese Herbal; Ginsenosides; Hippocampus; Humans; Indans; Insulysin; Male; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Neprilysin; Neuropsychological Tests; Piperidines; Presenilin-1; Space Perception; Time Factors | 2009 |
Drug-induced torsades de pointes: data mining of the public version of the FDA Adverse Event Reporting System (AERS).
Topics: Adverse Drug Reaction Reporting Systems; Amiodarone; Anti-Bacterial Agents; Antidepressive Agents; Antipsychotic Agents; Cardiovascular Agents; Databases, Factual; Donepezil; Famotidine; Humans; Indans; Methadone; Mitoxantrone; Piperidines; Torsades de Pointes; United States; United States Food and Drug Administration | 2009 |
Acute but not chronic donepezil increases muscarinic receptor-mediated signaling via arachidonic acid in unanesthetized rats.
Topics: Acetylcholine; Analysis of Variance; Animals; Arachidonic Acid; Autoradiography; Brain; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Enzyme Activation; Indans; Male; Phospholipases A2; Piperidines; Rats; Rats, Inbred F344; Receptors, Muscarinic; Signal Transduction; Time Factors; Triatoma; Wakefulness | 2009 |
Dopamine D3 receptor gene polymorphism influences on behavioral and psychological symptoms of dementia (BPSD) in mild dementia of Alzheimer's type.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Behavioral Symptoms; Case-Control Studies; Chi-Square Distribution; DNA Mutational Analysis; Donepezil; Dopamine Plasma Membrane Transport Proteins; Female; Gene Frequency; Genotype; Humans; Indans; Male; Mental Status Schedule; Nootropic Agents; Piperidines; Polymorphism, Genetic; Receptors, Dopamine D3 | 2009 |
Top cited papers in international psychogeriatrics: 3. Efficacy of donepezil on behavioral symptoms in patients with moderate to severe Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cluster Analysis; Donepezil; Humans; Indans; Piperidines; Psychometrics; Randomized Controlled Trials as Topic; Research Design; Treatment Outcome | 2009 |
[How long should drug therapy be continued for Alzheimer disease?].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2009 |
Phencyclidine-induced cognitive deficits in mice are ameliorated by subsequent subchronic administration of donepezil: role of sigma-1 receptors.
Topics: Analysis of Variance; Animals; Anisoles; Brain; Cell Membrane; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Hippocampus; Immunohistochemistry; Indans; Male; Mice; Mice, Inbred ICR; Phencyclidine; Physostigmine; Piperidines; Propylamines; Receptors, sigma; Recognition, Psychology; Sigma-1 Receptor; Tritium | 2009 |
Effects of cholinesterase inhibition on brain white matter volume in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Brain; Brain Mapping; Cholinesterase Inhibitors; Cytoprotection; Disease Progression; Donepezil; Drug Synergism; Drug Therapy, Combination; Female; Galantamine; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Nerve Fibers, Myelinated; Neural Pathways; Neuroprotective Agents; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2009 |
Effects of rivastigmine and donepezil on brain acetylcholine levels in acetylcholinesterase-deficient mice.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Female; Hippocampus; Indans; Male; Mice; Mice, Knockout; Microdialysis; Phenylcarbamates; Piperidines; Rivastigmine | 2009 |
Predicting time to nursing home placement based on activities of daily living scores--a modelling analysis using data on Alzheimer's disease patients receiving rivastigmine or donepezil.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Disease Progression; Donepezil; Female; Forecasting; Humans; Indans; Male; Middle Aged; Neuroprotective Agents; Nursing Homes; Patient Transfer; Phenylcarbamates; Piperidines; Proportional Hazards Models; Prospective Studies; Psychometrics; Randomized Controlled Trials as Topic; Risk Assessment; Rivastigmine; Severity of Illness Index | 2009 |
Effects of chronic donepezil treatment and cholinergic deafferentation on parietal pyramidal neuron morphology.
Topics: Acetylcholine; Afferent Pathways; Analysis of Variance; Animals; Antibodies, Monoclonal; Biotin; Calbindins; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Dendritic Spines; Denervation; Dextrans; Donepezil; Drug Administration Schedule; Immunotoxins; Indans; Male; Parietal Lobe; Parvalbumins; Piperidines; Pyramidal Cells; Rats; Rats, Wistar; Ribosome Inactivating Proteins, Type 1; S100 Calcium Binding Protein G; Saporins | 2009 |
Additive protective effects of donepezil and nicotine against salsolinol-induced cytotoxicity in SH-SY5Y cells.
Topics: Analysis of Variance; Annexin A5; Apoptosis; Atropine; Cell Cycle; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Combinations; Drug Interactions; Flow Cytometry; Gene Expression Regulation, Neoplastic; Humans; Indans; Mecamylamine; Neuroblastoma; Nicotine; Nicotinic Agonists; Nicotinic Antagonists; Piperidines; Propidium; Salsoline Alkaloids | 2009 |
Scopolamine-induced deficits in social memory in mice: reversal by donepezil.
Topics: Animals; Anti-Anxiety Agents; Cholinesterase Inhibitors; Diazepam; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Indans; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Muscarinic Antagonists; Neuropsychological Tests; Nootropic Agents; Piperidines; Random Allocation; Scopolamine; Social Behavior; Time Factors | 2009 |
[Protection effects of acetylcholinesterase inhibitors on apoptosis].
Topics: Animals; Apoptosis; Cell Count; Cell Proliferation; Cell Survival; Chlorocebus aethiops; Cholinesterase Inhibitors; Donepezil; Drug Antagonism; HeLa Cells; Hepatitis B; Humans; Indans; Lipopolysaccharides; Piperidines; Tacrine; Vero Cells | 2008 |
Persistence with cholinesterase inhibitor therapy for dementia: an observational administrative health database study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Databases, Factual; Delayed-Action Preparations; Dementia; Donepezil; Follow-Up Studies; Galantamine; Humans; Indans; Medication Adherence; Phenylcarbamates; Piperidines; Rivastigmine | 2009 |
Response to "Results, rhetoric, and randomized trials: the case of donepezil".
Topics: Advertising; Aged; Alzheimer Disease; Conflict of Interest; Donepezil; Drug Industry; Drug Utilization; Economic Competition; Evidence-Based Medicine; Humans; Indans; Manuscripts, Medical as Topic; Marketing; Nootropic Agents; Piperidines; Psycholinguistics; Randomized Controlled Trials as Topic | 2009 |
Increase of SCF plasma concentration during donepezil treatment of patients with early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Biomarkers; Brief Psychiatric Rating Scale; Donepezil; Female; Humans; Indans; Male; Piperidines; Stem Cell Factor; Time Factors; Treatment Outcome | 2009 |
The inhibitory avoidance test optimized for discovery of cognitive enhancers.
Topics: Animals; Avoidance Learning; Donepezil; Drug Evaluation, Preclinical; Drug Interactions; Indans; Male; Mice; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Scopolamine; Tacrine | 2009 |
Donepezil-induced adverse side effects of cardiac rhythm: 2 cases report of atrioventricular block and Torsade de Pointes.
Topics: Aged, 80 and over; Atrioventricular Block; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Piperidines; Torsades de Pointes | 2009 |
The aryl acylamidase activity is much more sensitive to Alzheimer drugs than the esterase activity of acetylcholinesterase in chicken embryonic brain.
Topics: Acetylcholinesterase; Amidohydrolases; Animals; Benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(N,N-dimethyl-N-2-propenyl-), Dibromide; Brain; Chick Embryo; Chickens; Cholinesterase Inhibitors; Donepezil; Enzyme Activation; Esterases; In Vitro Techniques; Indans; Isoflurophate; Piperidines; Tacrine | 2009 |
Cholinesterase inhibitor and N-methyl-D-aspartic acid receptor antagonist use in older adults with end-stage dementia: a survey of hospice medical directors.
Topics: Age Factors; Aged; Aged, 80 and over; Antiparkinson Agents; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Health Care Surveys; Health Status Indicators; Hospice Care; Humans; Indans; Male; Memantine; Palliative Care; Physician Executives; Piperidines; Receptors, N-Methyl-D-Aspartate | 2009 |
Drug-induced sialorrhoea and excessive saliva accumulation.
Topics: Antipsychotic Agents; Benzodiazepines; Cholinesterase Inhibitors; Clozapine; Deglutition Disorders; Donepezil; Galantamine; Humans; Hypnotics and Sedatives; Indans; Phenylcarbamates; Pilocarpine; Piperidines; Quality of Life; Risperidone; Rivastigmine; Sialorrhea | 2009 |
The role of nicotinic receptors in the amelioration of cholinesterase inhibitors in scopolamine-induced memory deficits.
Topics: Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Hippocampus; Indans; Learning Disabilities; Male; Maze Learning; Mecamylamine; Muscarinic Agonists; Nicotine; Nicotinic Antagonists; Physostigmine; Pilocarpine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Scopolamine; Theta Rhythm | 2009 |
Effect of donepezil on reversal learning in a touch screen-based operant task.
Topics: Animals; Cholinesterase Inhibitors; Computer Peripherals; Conditioning, Operant; Discrimination Learning; Donepezil; Indans; Male; Piperidines; Rats; Rats, Inbred Strains; Reversal Learning | 2009 |
Cholinoceptive and cholinergic properties of cardiomyocytes involving an amplification mechanism for vagal efferent effects in sparsely innervated ventricular myocardium.
Topics: Acetylcholine; Animals; Cells, Cultured; Choline O-Acetyltransferase; Donepezil; Heart Ventricles; Humans; Indans; Mice; Muscarinic Agonists; Myocytes, Cardiac; Piperidines; Rats; RNA, Small Interfering; Vagus Nerve; Vesicular Acetylcholine Transport Proteins | 2009 |
How to manage overactive bladder in elderly individuals with dementia? A combined use of donepezil, a central acetylcholinesterase inhibitor, and propiverine, a peripheral muscarine receptor antagonist.
Topics: Aged; Aged, 80 and over; Benzilates; Chi-Square Distribution; Cholinergic Antagonists; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Male; Middle Aged; Piperidines; Prospective Studies; Surveys and Questionnaires; Treatment Outcome; Urinary Bladder, Overactive | 2009 |
Evidence of carrier-mediated transport in the penetration of donepezil into the rat brain.
Topics: Animals; Biological Transport, Active; Blood-Brain Barrier; Brain; Cell Line, Transformed; Choline; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Indans; Male; Organic Cation Transport Proteins; Piperidines; Rats; Rats, Sprague-Dawley; Transfection | 2010 |
A study of brain insulin receptors, AChE activity and oxidative stress in rat model of ICV STZ induced dementia.
Topics: Acetylcholinesterase; Animals; Antibiotics, Antineoplastic; Biomarkers; Blood Glucose; Blotting, Western; Body Weight; Brain Chemistry; Cholinesterase Inhibitors; Dementia; Donepezil; Electrophoresis, Polyacrylamide Gel; Glutathione; Indans; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Oxidative Stress; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Streptozocin | 2009 |
International price comparisons of Alzheimer's drugs: a way to close the affordability gap.
Topics: Aged; Alzheimer Disease; Cross-Cultural Comparison; Developing Countries; Donepezil; Drug Costs; Economics; Galantamine; Humans; Income; Indans; India; Memantine; Mexico; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine; United States | 2009 |
Effect of a CYP2D6 polymorphism on the efficacy of donepezil in patients with Alzheimer disease.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Apolipoproteins E; Cohort Studies; Cytochrome P-450 CYP2D6; Donepezil; Female; Follow-Up Studies; Gene Frequency; Genotype; Humans; Indans; Male; Piperidines; Polymorphism, Single Nucleotide; Prospective Studies | 2009 |
Current treatments of Alzheimer disease: are main caregivers satisfied with the drug treatments received by their patients?
Topics: Aged; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cross-Sectional Studies; Donepezil; Excitatory Amino Acid Antagonists; Female; Galantamine; Humans; Indans; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Patient Compliance; Patient Satisfaction; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Psychometrics; Rivastigmine; Socioeconomic Factors; Spain; Surveys and Questionnaires | 2009 |
Responses of hypothalamo-pituitary-adrenal axis to a cholinesterase inhibitor.
Topics: Adrenocorticotropic Hormone; Animals; Anorexia; Appetite; Appetite Regulation; Cholinesterase Inhibitors; Donepezil; Drug Administration Schedule; Hypothalamo-Hypophyseal System; Indans; Male; Neurosecretory Systems; Paraventricular Hypothalamic Nucleus; Piperidines; Pituitary-Adrenal System; Proto-Oncogene Proteins c-fos; Rats; Rats, Wistar; Up-Regulation | 2009 |
Effectiveness of donepezil, rivastigmine, and (+/-)huperzine A in counteracting the acute toxicity of organophosphorus nerve agents: comparison with galantamine.
Topics: Acetylcholinesterase; Alkaloids; Animals; Antidotes; Chemical Warfare Agents; Donepezil; Dose-Response Relationship, Drug; Galantamine; Guinea Pigs; Indans; Lethal Dose 50; Male; Phenylcarbamates; Piperidines; Poisoning; Rivastigmine; Sesquiterpenes; Soman; Time Factors; Toxicity Tests, Acute | 2009 |
Neurometabolic correlations of donepezil and rivastigmine in dementia patients: a different neuroprotective effect.
Topics: Aged; Aspartic Acid; Brain; Cognition Disorders; Dementia; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Male; Middle Aged; Neuroprotective Agents; Neuropsychological Tests; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Rivastigmine; Treatment Outcome | 2009 |
Turbocharging the brain.
Topics: Alzheimer Disease; Benzhydryl Compounds; Brain; Central Nervous System Agents; Central Nervous System Stimulants; Cognition; Donepezil; Drug Industry; Humans; Indans; Legislation, Drug; Memory; Methylphenidate; Modafinil; Nootropic Agents; Piperidines; United States; United States Food and Drug Administration | 2009 |
Occupational contact urticaria caused by donepezil.
Topics: Adult; Cholinesterase Inhibitors; Donepezil; Female; Hand Dermatoses; Humans; Indans; Nurses; Occupational Exposure; Patch Tests; Piperidines; Urticaria | 2009 |
Cholinergic protection via alpha7 nicotinic acetylcholine receptors and PI3K-Akt pathway in LPS-induced neuroinflammation.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Anti-Inflammatory Agents; Brain; Cholinesterase Inhibitors; Cyclooxygenase 2; Donepezil; Encephalitis; Glutathione; Indans; Inflammation Mediators; Interleukin-1beta; Lipopolysaccharides; Male; Malondialdehyde; Nitric Oxide Synthase Type II; Oxidative Stress; Phosphatidylinositol 3-Kinases; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Tumor Necrosis Factor-alpha | 2010 |
Cholinesterase inhibitors and incidence of bradycardia in patients with dementia in the veterans affairs new England healthcare system.
Topics: Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Cross-Sectional Studies; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Therapy, Combination; Galantamine; Heart Rate; Hospitals, Veterans; Humans; Incidence; Indans; Massachusetts; Nootropic Agents; Phenylcarbamates; Piperidines; Risk; Rivastigmine; Veterans | 2009 |
Effects of donepezil on amyloid-beta and synapse density in the Tg2576 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Biomarkers; Cholinesterase Inhibitors; Dentate Gyrus; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Hippocampus; Humans; Indans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron, Transmission; Neuroprotective Agents; Piperidines; Plaque, Amyloid; Synapses; Synaptophysin; Time; Treatment Outcome | 2009 |
Case report: combined use of donepezil and galantamine in mixed dementia.
Topics: Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Therapy, Combination; Galantamine; Humans; Indans; Male; Piperidines | 2009 |
Metabolic profiling of rat brain and cognitive behavioral tasks: potential complementary strategies in preclinical cognition enhancement research.
Topics: Animals; Behavior, Animal; Brain Chemistry; Cognition; Donepezil; Galantamine; Indans; Male; Metabolome; Piperidines; Rats; Rats, Inbred Strains; Tandem Mass Spectrometry | 2009 |
Treatment of musical hallucinosis with acetylcholinesterase inhibitors.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Hallucinations; Humans; Indans; Male; Middle Aged; Music; Piperidines | 2009 |
Anti-Alzheimer's drug, donepezil, markedly improves long-term survival after chronic heart failure in mice.
Topics: Alzheimer Disease; Animals; Disease Models, Animal; Donepezil; Heart Failure; Indans; Male; Mice; Piperidines; Survival Rate; Time Factors; Treatment Outcome | 2009 |
Effects of anti-dementia drugs on morphine-induced somnolence.
Topics: Animals; Dementia; Donepezil; Electroencephalography; Electromyography; Indans; Male; Memantine; Methylphenidate; Morphine; Piperidines; Rats; Rats, Wistar; Sleep Stages | 2009 |
Okadaic acid (ICV) induced memory impairment in rats: a suitable experimental model to test anti-dementia activity.
Topics: Animals; Brain; Calcium Signaling; Cholinesterase Inhibitors; Dementia; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glutathione; Indans; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Memantine; Memory; Memory Disorders; Neuropsychological Tests; Nitrites; Okadaic Acid; Oxidative Stress; Piperidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Treatment Outcome | 2010 |
Donepezil treatment of patients with MCI: a 48-week randomized, placebo- controlled trial.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition Disorders; Confounding Factors, Epidemiologic; Donepezil; Humans; Indans; Nootropic Agents; Observer Variation; Patient Dropouts; Piperidines; Randomized Controlled Trials as Topic | 2009 |
Dementia: Does depression predict donepezil response in MCI?
Topics: Cognition Disorders; Dementia; Depression; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2009 |
Donepezil- and scopolamine-induced rCMRglu changes assessed by PET in conscious rhesus monkeys.
Topics: Animals; Brain; Cholinesterase Inhibitors; Consciousness; Donepezil; Drug Combinations; Fluorodeoxyglucose F18; Glucose; Indans; Macaca mulatta; Male; Piperidines; Positron-Emission Tomography; Scopolamine | 2009 |
Torsades de Pointes with QT prolongation related to donepezil use.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Colitis; Donepezil; Electrocardiography; Female; Humans; Indans; Isoproterenol; Lidocaine; Long QT Syndrome; Magnesium Sulfate; Nootropic Agents; Piperidines; Potassium Chloride; Syncope; Torsades de Pointes; Treatment Outcome | 2009 |
Effect of the cholinesterase inhibitor donepezil on cardiac remodeling and autonomic balance in rats with heart failure.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Heart; Heart Failure; Heart Rate; Indans; Male; Myocardial Infarction; Piperidines; Rats; Rats, Sprague-Dawley; Vagus Nerve | 2010 |
Donepezil, an acetylcholinesterase inhibitor against Alzheimer's dementia, promotes angiogenesis in an ischemic hindlimb model.
Topics: Acetylcholine; Alzheimer Disease; Animals; Caspase 3; Caspase 7; Cholinesterase Inhibitors; Donepezil; Endothelial Cells; Hindlimb; Humans; Hypoxia; Indans; Indocyanine Green; Ischemia; Mice; Mice, Knockout; Microscopy, Fluorescence; Neovascularization, Pathologic; Piperidines; Vascular Endothelial Growth Factor A | 2010 |
[Adverse events causing discontinuation of donepezil for Alzheimer's dementia].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Appetite; Cholinesterase Inhibitors; Diarrhea; Donepezil; Female; Humans; Indans; Male; Nausea; Nootropic Agents; Piperidines; Retrospective Studies; Vomiting | 2009 |
No effect of donepezil on striatal dopamine release in mild to moderate Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Corpus Striatum; Donepezil; Dopamine; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Positron-Emission Tomography | 2010 |
Piperine, the main alkaloid of Thai black pepper, protects against neurodegeneration and cognitive impairment in animal model of cognitive deficit like condition of Alzheimer's disease.
Topics: Acetylcholinesterase; Alkaloids; Alzheimer Disease; Animals; Aziridines; Benzodioxoles; Choline; Cognition Disorders; Donepezil; Hippocampus; Indans; Injections, Intraventricular; Lipid Peroxidation; Male; Malondialdehyde; Maze Learning; Nerve Degeneration; Neuromuscular Blocking Agents; Neuroprotective Agents; Nootropic Agents; Piper nigrum; Piperidines; Polyunsaturated Alkamides; Rats; Space Perception; Thailand | 2010 |
Cholinergic activation of hippocampal neural stem cells in aged dentate gyrus.
Topics: Acetylcholine; Aging; Animals; Cell Proliferation; Cholinesterase Inhibitors; Dentate Gyrus; Donepezil; Humans; Indans; Mice; Mice, Transgenic; Microscopy, Confocal; Muscarinic Agonists; Neural Stem Cells; Neurogenesis; Neurons; Nootropic Agents; Physostigmine; Piperidines; Receptors, Muscarinic | 2011 |
Donepezil treatment and changes in hippocampal structure in very mild Alzheimer disease.
Topics: Aged; Alzheimer Disease; Atrophy; Brain Mapping; Cholinesterase Inhibitors; Cognition Disorders; Cohort Studies; Disease Progression; Donepezil; Female; Hippocampus; Humans; Image Processing, Computer-Assisted; Indans; Longitudinal Studies; Magnetic Resonance Imaging; Male; Nerve Degeneration; Piperidines; Time Factors; Treatment Outcome | 2010 |
Prescribing of drugs for Alzheimer's disease: a South African database analysis.
Topics: Aged; Alzheimer Disease; Cohort Studies; Cost-Benefit Analysis; Costs and Cost Analysis; Donepezil; Drug Prescriptions; Female; Galantamine; Humans; Indans; Male; Memantine; Nootropic Agents; Piperidines; Practice Patterns, Physicians'; Retrospective Studies; South Africa | 2010 |
Effects of donepezil, galantamine and rivastigmine in 938 Italian patients with Alzheimer's disease: a prospective, observational study.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Apolipoproteins E; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Galantamine; Genetic Variation; Genotype; Humans; Indans; Italy; Male; Outcome Assessment, Health Care; Phenylcarbamates; Piperidines; Prospective Studies; Psychiatric Status Rating Scales; Rivastigmine; Severity of Illness Index; Time Factors; Treatment Outcome | 2010 |
Changes in cognitive functions of patients with dementia of the Alzheimer type following long-term administration of donepezil hydrochloride: relating to changes attributable to differences in apolipoprotein E phenotype.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Brief Psychiatric Rating Scale; Cognition; Cross-Sectional Studies; Disease Progression; Donepezil; Humans; Indans; Longitudinal Studies; Male; Neuropsychological Tests; Nootropic Agents; Phenotype; Piperidines; Prognosis; Retrospective Studies; Treatment Outcome | 2010 |
Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits.
Topics: Animals; Buprenorphine; Cholinesterase Inhibitors; Donepezil; Indans; Male; Narcotic Antagonists; Phrenic Nerve; Piperidines; Rabbits; Respiratory Insufficiency | 2009 |
Microglia signaling as a target of donepezil.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell Line; Cell Line, Tumor; Cells, Cultured; Coculture Techniques; Disease Models, Animal; Donepezil; Encephalitis; Gene Expression; Indans; Interleukin-1beta; Mice; Microglia; Neuroimmunomodulation; NF-kappa B; Nitric Oxide; Nitric Oxide Synthase Type II; Piperidines; Rats; Signal Transduction; Tumor Necrosis Factor-alpha | 2010 |
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates.
Topics: Acetylcholinesterase; Alzheimer Disease; Amino Acid Motifs; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Drug Discovery; Humans; Indans; Models, Molecular; Piperidines; Protein Multimerization; Protein Structure, Quaternary; Quinolines; Tacrine | 2010 |
Targeting Alzheimer's disease: Novel indanone hybrids bearing a pharmacophoric fragment of AP2238.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antineoplastic Combined Chemotherapy Protocols; Benzylamines; Binding Sites; Bleomycin; Cholinesterase Inhibitors; Computer Simulation; Coumarins; Donepezil; Humans; Indans; Lomustine; Methotrexate; Peptide Fragments; Piperidines; Recombinant Proteins; Stilbenes; Structure-Activity Relationship; Tetrahydronaphthalenes | 2010 |
Mechanisms of chronic nicotine treatment-induced enhancement of the sensitivity of cortical neurons to the neuroprotective effect of donepezil in cortical neurons.
Topics: Animals; Cell Survival; Cells, Cultured; Cerebral Cortex; Donepezil; Drug Synergism; Indans; Neurons; Neuroprotective Agents; Nicotine; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Up-Regulation | 2010 |
Gonadal hormones modulate the potency of the disruptive effects of donepezil in male rats responding under a nonspatial operant learning and performance task.
Topics: Animals; Brain; Cholinesterase Inhibitors; Conditioning, Operant; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Gonadal Hormones; Hormone Replacement Therapy; Indans; Male; Piperidines; Rats; Rats, Long-Evans; Reinforcement Schedule; Testosterone | 2010 |
Drug treatment of Alzheimer's disease patients leads to expression changes in peripheral blood cells.
Topics: Alzheimer Disease; Analysis of Variance; Blood Cells; Cholinesterase Inhibitors; Clinical Trials as Topic; Donepezil; Galantamine; Gene Expression Regulation; Genome-Wide Association Study; Humans; Indans; Microarray Analysis; Phenylcarbamates; Piperidines; Principal Component Analysis; Rivastigmine; RNA | 2010 |
Cognition-enhancing properties of Dimebon in a rat novel object recognition task are unlikely to be associated with acetylcholinesterase inhibition or N-methyl-D-aspartate receptor antagonism.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Behavior, Animal; Brain Chemistry; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; Indans; Indoles; Male; Memantine; Microdialysis; Piperidines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Receptors, Histamine H1; Receptors, N-Methyl-D-Aspartate; Recognition, Psychology | 2010 |
Histological protection by donepezil against neurodegeneration induced by ischemia-reperfusion in the rat retina.
Topics: Animals; Donepezil; Indans; Male; Neurodegenerative Diseases; Neuroprotective Agents; Piperidines; Rats; Rats, Sprague-Dawley; Reperfusion Injury; Retinal Degeneration; Retinal Vessels; Vitreous Body | 2010 |
Galantamine ameliorates the impairment of recognition memory in mice repeatedly treated with methamphetamine: involvement of allosteric potentiation of nicotinic acetylcholine receptors and dopaminergic-ERK1/2 systems.
Topics: Acetylcholine; Adrenergic Uptake Inhibitors; Animals; Cholinesterase Inhibitors; Cognition; Donepezil; Dopamine; Dopamine Agonists; Galantamine; Indans; Male; Memory; Methamphetamine; Mice; Mice, Inbred ICR; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Piperidines; Receptors, Muscarinic; Receptors, Nicotinic; Recognition, Psychology | 2010 |
[Case of dementia with Lewy bodies showing cervical dystonia after donepezil administration].
Topics: Aged; Donepezil; Electromyography; Female; Humans; Indans; Lewy Body Disease; Piperidines; Torticollis | 2010 |
Phencyclidine withdrawal disrupts episodic-like memory in rats: reversal by donepezil but not clozapine.
Topics: Animals; Clozapine; Donepezil; Indans; Male; Memory Disorders; Memory, Episodic; Phencyclidine; Piperidines; Rats; Substance Withdrawal Syndrome | 2010 |
Lower Barthel Index scores predict less prescription of pharmacological therapy in elderly patients with Alzheimer disease.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Comorbidity; Donepezil; Drug Utilization; Female; Galantamine; Geriatric Assessment; Humans; Indans; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Phenylcarbamates; Piperidines; Psychiatric Status Rating Scales; Psychotropic Drugs; Rivastigmine; Socioeconomic Factors | 2010 |
Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration.
Topics: Aging; Animals; Brain; Dendritic Spines; Donepezil; Hippocampus; Indans; Male; Neurons; Nootropic Agents; Nucleus Accumbens; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Silver Staining; Statistics, Nonparametric; Time Factors | 2010 |
Effect of donepezil on the continuum of depressive symptoms, mild cognitive impairment, and progression to dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition Disorders; Depressive Disorder; Disease Progression; Donepezil; Humans; Indans; Nootropic Agents; Piperidines | 2010 |
Impact of donepezil hydrochloride on the care burden of family caregivers of patients with Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cost of Illness; Donepezil; Female; Humans; Indans; Japan; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Piperidines; Product Surveillance, Postmarketing; Prospective Studies; Surveys and Questionnaires; Treatment Outcome | 2009 |
Anticholinesterase duration in the Australian veteran population.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Australia; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Galantamine; Humans; Indans; Male; Medication Adherence; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Time Factors; Treatment Outcome; Veterans | 2010 |
Use of a novel radiometric method to assess the inhibitory effect of donepezil on acetylcholinesterase activity in minimally diluted tissue samples.
Topics: Acetylcholinesterase; Adult; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Humans; Hydrolysis; Indans; Kinetics; Male; Piperidines; Radiometry | 2010 |
Cost effectiveness of donepezil in the treatment of mild to moderate Alzheimer's disease: a UK evaluation using discrete-event simulation.
Topics: Aged; Aged, 80 and over; Algorithms; Alzheimer Disease; Caregivers; Computer Simulation; Cost of Illness; Cost-Benefit Analysis; Databases, Factual; Donepezil; Drug Costs; Female; Health Care Costs; Humans; Indans; Male; Models, Economic; Nootropic Agents; Piperidines; Quality-Adjusted Life Years; Randomized Controlled Trials as Topic; Registries; Treatment Outcome; United Kingdom | 2010 |
The selective 5-HT(1A) receptor antagonist NAD-299 increases acetylcholine release but not extracellular glutamate levels in the frontal cortex and hippocampus of awake rat.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Area Under Curve; Benzopyrans; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Extracellular Fluid; Frontal Lobe; Glutamic Acid; Hippocampus; Indans; Male; Microdialysis; Neostigmine; Piperidines; Rats; Rats, Sprague-Dawley; Serotonin Antagonists; Serotonin Receptor Agonists; Wakefulness | 2010 |
A pilot study for the effects of donepezil therapy on cerebral and optic nerve head blood flow, visual field defect in normal-tension glaucoma.
Topics: Administration, Oral; Aged; Blood Flow Velocity; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Intraocular Pressure; Iofetamine; Laser-Doppler Flowmetry; Low Tension Glaucoma; Male; Optic Disk; Pilot Projects; Piperidines; Radiopharmaceuticals; Regional Blood Flow; Tomography, Emission-Computed, Single-Photon; Vision Disorders; Visual Fields | 2010 |
Preliminary use of insulin-like growth factor-I as a biomarker for sorting high-dose donepezil responders among Japanese patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Asian People; Biomarkers; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Insulin-Like Growth Factor I; Japan; Male; Piperidines | 2010 |
Established donepezil treatment modulates task relevant regional brain activation in early Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Donepezil; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Piperidines; Psychomotor Performance; Reaction Time; Treatment Outcome | 2010 |
In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease.
Topics: Acetylcholine; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Avoidance Learning; Behavior, Animal; Cognition; Cyclic AMP Response Element-Binding Protein; Donepezil; Electroencephalography; Extracellular Signal-Regulated MAP Kinases; Glycogen Synthase Kinase 3; Indans; Indoles; Macaca mulatta; Male; Mice; Mice, Knockout; Nicotinic Agonists; Nootropic Agents; Phosphorylation; Piperidines; Psychomotor Performance; Quinuclidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; Recognition, Psychology; Social Perception; tau Proteins | 2010 |
Treatment disparities in medication prescribing for Alzheimer's: disease among ethnic groups.
Topics: Age Factors; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Healthcare Disparities; Humans; Indans; Male; Medicare; Piperidines; Practice Patterns, Physicians'; Severity of Illness Index; Sex Factors; United States | 2009 |
Inappropriate sexual behaviors associated with donepezil treatment: a case report.
Topics: Aged; Donepezil; Follow-Up Studies; Humans; Indans; Male; Masturbation; Piperidines; Sexual Behavior; Sexual Harassment | 2010 |
Donepezil, a potent acetylcholinesterase inhibitor, induces caspase-dependent apoptosis in human promyelocytic leukemia HL-60 cells.
Topics: Annexin A5; Apoptosis; Caspases; Cholinesterase Inhibitors; Cytochromes c; Cytosol; DNA Fragmentation; Donepezil; Dose-Response Relationship, Drug; Enzyme Inhibitors; HeLa Cells; HL-60 Cells; Humans; Indans; Leukemia, Promyelocytic, Acute; Membrane Potential, Mitochondrial; Piperidines; Proto-Oncogene Proteins c-bcl-2; U937 Cells | 2010 |
Risk factors for nursing home placement in Alzheimer's disease: a longitudinal study of cognition, ADL, service utilization, and cholinesterase inhibitor treatment.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Galantamine; Humans; Indans; Kaplan-Meier Estimate; Male; Middle Aged; Nursing Homes; Phenylcarbamates; Piperidines; Proportional Hazards Models; Prospective Studies; Risk Factors; Rivastigmine; Severity of Illness Index; Sex Factors; Sweden | 2011 |
How do we treat people with dementia in Croatia.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Croatia; Cross-Cultural Comparison; Cross-Sectional Studies; Donepezil; Drug Approval; Drug Costs; Humans; Indans; Memantine; National Health Programs; Nootropic Agents; Phenylcarbamates; Piperidines; Reimbursement Mechanisms; Rivastigmine | 2010 |
Predictors of adherence among Alzheimer's disease patients receiving oral therapy.
Topics: Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Dopamine Agents; Female; Galantamine; Humans; Indans; Insurance Claim Review; Logistic Models; Male; Medication Adherence; Memantine; Neuroprotective Agents; Nootropic Agents; Phenylcarbamates; Piperidines; Predictive Value of Tests; Retrospective Studies; Rivastigmine; Treatment Outcome | 2010 |
Donepezil and concurrent sertraline treatment is associated with increased hippocampal volume in a patient with depression.
Topics: Adult; Alzheimer Disease; Atrophy; Cholinesterase Inhibitors; Cognition Disorders; Depressive Disorder, Major; Diagnosis, Differential; Donepezil; Drug Therapy, Combination; Female; Follow-Up Studies; Functional Laterality; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Piperidines; Selective Serotonin Reuptake Inhibitors; Sertraline; Treatment Outcome | 2010 |
Alternative method of oral dosing for rats.
Topics: Administration, Oral; Animals; Behavior, Animal; Donepezil; Galantamine; Indans; Laboratory Animal Science; Male; Nicotine; Nootropic Agents; Piperidines; Rats; Recognition, Psychology; Stress, Physiological; Sucrose; Syringes; Time Factors | 2010 |
Investigation into the efficacy of the acetylcholinesterase inhibitor, donepezil, and novel procognitive agents to induce gamma oscillations in rat hippocampal slices.
Topics: Animals; Brain Waves; Cholinesterase Inhibitors; Donepezil; Electrophysiology; Hippocampus; Indans; Neurons; Nootropic Agents; Piperidines; Quinolones; Rats | 2010 |
Efficacy of low-dose donepezil for visual hallucinations in a patient with dementia with Lewy bodies.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Hallucinations; Humans; Indans; Lewy Body Disease; Piperidines | 2010 |
[Variability and trends in dementia drug consumption in Castile-La Mancha (Spain). Estimated prevalence of Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Galantamine; Ginkgo biloba; Humans; Indans; Memantine; Neuroprotective Agents; Nootropic Agents; Observer Variation; Phenylcarbamates; Piperidines; Plant Extracts; Rivastigmine; Spain; Substance-Related Disorders | 2010 |
The effect of donepezil treatment on cardiovascular mortality.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cardiovascular Diseases; Cholinesterase Inhibitors; Cohort Studies; Dementia, Vascular; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Nootropic Agents; Piperidines; Proportional Hazards Models; Retrospective Studies | 2010 |
Memantine-related psychotic symptoms in a patient with bipolar disorder.
Topics: Alzheimer Disease; Antimanic Agents; Bipolar Disorder; Donepezil; Drug Interactions; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Memantine; Middle Aged; Nootropic Agents; Piperidines; Psychoses, Substance-Induced | 2010 |
Prescribing trends in cognition enhancing drugs in Australia.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Australia; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Humans; Indans; Male; Memantine; Middle Aged; Nootropic Agents; Piperidines; Practice Patterns, Physicians'; Sex Factors | 2011 |
Preparation and evaluation of taste-masked donepezil hydrochloride orally disintegrating tablets.
Topics: Administration, Oral; Animals; Biological Availability; Donepezil; Drug Carriers; Drug Compounding; Humans; Indans; Male; Microscopy, Electron, Scanning; Microspheres; Particle Size; Piperidines; Polymethacrylic Acids; Rats; Rats, Sprague-Dawley; Saliva; Solubility; Surface Properties; Tablets; Taste; Taste Threshold; X-Ray Diffraction | 2010 |
Compliance assessment of ambulatory Alzheimer patients to aid therapeutic decisions by healthcare professionals.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Ambulatory Care; Computer Simulation; Decision Making; Donepezil; Female; Health Personnel; Humans; Indans; Male; Middle Aged; Nootropic Agents; Observation; Patient Compliance; Pilot Projects; Piperidines | 2010 |
Neuroprotection by donepezil against glutamate excitotoxicity involves stimulation of alpha7 nicotinic receptors and internalization of NMDA receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Calcium; Cells, Cultured; Donepezil; Glutamic Acid; Indans; Neurons; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; src-Family Kinases | 2010 |
Acetylcholinesterase inhibitors attenuate atherogenesis in apolipoprotein E-knockout mice.
Topics: Alzheimer Disease; Animals; Apolipoproteins E; Atherosclerosis; Cardiovascular Diseases; Cholinesterase Inhibitors; Cytokines; Donepezil; Indans; Inflammation; Lipopolysaccharides; Male; Mice; Mice, Knockout; Oxidative Stress; Piperidines; Sepsis | 2010 |
Investigation of responders and non-responders to long-term donepezil treatment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Female; Geriatric Assessment; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Retrospective Studies; Time Factors; Treatment Outcome | 2010 |
Effects of yokukansan and donepezil on learning disturbance and aggressiveness induced by intracerebroventricular injection of amyloid β protein in mice.
Topics: Aggression; Amyloid beta-Peptides; Animals; CHO Cells; Choline; Cricetinae; Cricetulus; Donepezil; Drugs, Chinese Herbal; Indans; Injections, Intraventricular; Learning; Membrane Transport Proteins; Mice; Piperidines; Protein Binding; Rats; Receptors, Cell Surface | 2011 |
Influence of apolipoprotein E varepsilon4 on rates of cognitive and functional decline in mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Apolipoprotein E4; Cholinesterase Inhibitors; Cognition Disorders; Disease Progression; Donepezil; Female; Follow-Up Studies; Genotype; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic; Retrospective Studies; Vitamin E | 2010 |
A new commercially viable synthetic route for donepezil hydrochloride: anti-Alzheimer's drug.
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Technology, Pharmaceutical | 2010 |
Think before you leap: donepezil reduces falls?
Topics: Accidental Falls; Cholinesterase Inhibitors; Decision Making; Donepezil; Dopamine; Humans; Indans; Parkinson Disease; Piperidines | 2010 |
Evaluation of the effect of donepezil on cerebral blood flow velocity in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Blood Flow Velocity; Cerebrovascular Circulation; Donepezil; Female; Humans; Indans; Iran; Male; Middle Aged; Middle Cerebral Artery; Nootropic Agents; Piperidines; Posterior Cerebral Artery; Retrospective Studies; Ultrasonography, Doppler, Transcranial | 2010 |
The influence of donepezil and EGb 761 on the innate immunity of human leukocytes: effect on the NF-κB system.
Topics: Animals; Cell Line; Cell Survival; Donepezil; Ginkgo biloba; Humans; Immunity, Innate; Indans; Leukocytes; Mice; NF-kappa B; Piperidines; Plant Extracts; Regression Analysis; Vesicular stomatitis Indiana virus; Virus Replication | 2010 |
Anti-inflammatory action of donepezil ameliorates tau pathology, synaptic loss, and neurodegeneration in a tauopathy mouse model.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Disease Models, Animal; Donepezil; Humans; Indans; Mice; Mice, Inbred C3H; Mice, Transgenic; Mutation; Nerve Degeneration; Piperidines; Synapses; tau Proteins; Tauopathies | 2010 |
Determining the minimum clinically important differences for outcomes in the DOMINO trial.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Data Interpretation, Statistical; Decision Making; Donepezil; Dopamine Agents; Humans; Indans; Memantine; Outcome Assessment, Health Care; Piperidines; Psychiatric Status Rating Scales; Randomized Controlled Trials as Topic | 2011 |
Cholinergic enhancement augments magnitude and specificity of visual perceptual learning in healthy humans.
Topics: Acetylcholine; Adolescent; Adult; Animals; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Learning; Neuropsychological Tests; Piperidines; Placebos; Visual Perception; Young Adult | 2010 |
Role of cytochrome P4502D6 functional polymorphisms in the efficacy of donepezil in patients with Alzheimer's disease.
Topics: Alzheimer Disease; Cohort Studies; Cytochrome P-450 CYP2D6; Donepezil; Female; Genetic Variation; Humans; Indans; Male; Nootropic Agents; Piperidines; Polymorphism, Genetic | 2011 |
Differential pharmacological responses of catatonia-like signs in frontotemporal dementia.
Topics: Aged; Amantadine; Antipsychotic Agents; Aripiprazole; Benzothiazoles; Catatonia; Citalopram; Clinical Trials as Topic; Dibenzothiazepines; Donepezil; Dopamine Agents; Excitatory Amino Acid Antagonists; Female; Frontotemporal Dementia; Humans; Hypnotics and Sedatives; Indans; Lorazepam; Memantine; Middle Aged; Nootropic Agents; Piperazines; Piperidines; Pramipexole; Quetiapine Fumarate; Quinolones; Selective Serotonin Reuptake Inhibitors | 2010 |
Low dose of donepezil improves gabapentin analgesia in the rat spared nerve injury model of neuropathic pain: single and multiple dosing studies.
Topics: Amines; Analgesics; Animals; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disease Models, Animal; Donepezil; Drug Administration Schedule; Drug Combinations; Drug Synergism; Gabapentin; gamma-Aminobutyric Acid; Indans; Male; Neuralgia; Peripheral Nervous System Diseases; Piperidines; Rats; Rats, Sprague-Dawley | 2010 |
Lack of a primary physicochemical determinant in the direct transport of drugs to the brain after nasal administration in rats: potential involvement of transporters in the pathway.
Topics: 1-Methyl-4-phenylpyridinium; Administration, Intranasal; Animals; Area Under Curve; Biological Transport; Blood-Brain Barrier; Brain; Chemical Phenomena; Donepezil; Gene Expression; HEK293 Cells; Humans; Hydrochlorothiazide; Indans; Linear Models; Male; Metoprolol; Nootropic Agents; Ofloxacin; Olfactory Mucosa; Organic Anion Transporters; Organic Anion Transporters, Sodium-Independent; Organic Cation Transport Proteins; Organic Cation Transporter 2; p-Aminohippuric Acid; Pharmaceutical Preparations; Pharmacokinetics; Piperidines; Ranitidine; Rats; Rats, Sprague-Dawley; Transfection | 2010 |
Do CYP3A and ABCB1 genotypes influence the plasma concentration and clinical outcome of donepezil treatment?
Topics: Adult; Aged; Aged, 80 and over; Alleles; Alzheimer Disease; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Donepezil; Female; Genotype; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines; Polymorphism, Single Nucleotide; Treatment Outcome; Young Adult | 2011 |
Use of antipsychotic drugs in patients with Alzheimer's disease treated with rivastigmine versus donepezil: a retrospective, parallel-cohort, hypothesis-generating study.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Antipsychotic Agents; Cholinesterase Inhibitors; Cohort Studies; Databases, Factual; Dementia; Donepezil; Female; Humans; Indans; Male; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Time Factors | 2010 |
Contribution of cyclooxygenase-dependent mechanisms to contractile responses to donepezil in the rat urinary bladder.
Topics: Animals; Atropine; Cholinesterase Inhibitors; Donepezil; Indans; Indomethacin; Male; Muscle Contraction; Neostigmine; Piperidines; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Urinary Bladder | 2010 |
Early Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Early Diagnosis; Humans; Indans; Piperidines | 2010 |
A computer-automated touchscreen paired-associates learning (PAL) task for mice: impairments following administration of scopolamine or dicyclomine and improvements following donepezil.
Topics: Animals; Automation; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Cues; Dicyclomine; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Indans; Male; Mice; Mice, Inbred C57BL; Neuropsychological Tests; Nootropic Agents; Paired-Associate Learning; Piperidines; Reaction Time; Reward; Scopolamine; Time Factors; Touch; User-Computer Interface | 2011 |
Bipolar affective disorder, type II, apparently precipitated by donepezil.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Female; Humans; Indans; Piperidines; Treatment Outcome | 2011 |
Plasma concentration of donepezil to the therapeutic response of Alzheimer's disease in Taiwanese.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Piperidines; Taiwan; Treatment Outcome | 2011 |
The emergence of pharmacotherapies for cognitive function in Down syndrome.
Topics: Adolescent; Child; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition; Donepezil; Dose-Response Relationship, Drug; Down Syndrome; Drug Tolerance; Humans; Indans; Multicenter Studies as Topic; Neuropsychological Tests; Piperidines; Randomized Controlled Trials as Topic; Time Factors; Treatment Outcome | 2010 |
Donepezil eliminates suppressive effects of β-amyloid peptide (1-42) on long-term potentiation in the hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Donepezil; Hippocampus; Indans; Long-Term Potentiation; Male; Neuroprotective Agents; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Statistics, Nonparametric | 2010 |
[The efficacy of donepezil hydrochloride on the Apathy scale in Alzheimer's disease].
Topics: Aged; Alzheimer Disease; Apathy; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2010 |
FK962 and donepezil act synergistically to improve cognition in rats: potential as an add-on therapy for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Benzamides; Cholinesterase Inhibitors; Cognition; Discrimination Learning; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Humans; Indans; Male; Models, Animal; Nootropic Agents; Photic Stimulation; Piperidines; Rats; Reward | 2011 |
Pharmacokinetic and pharmacodynamic properties of cholinesterase inhibitors donepezil, tacrine, and galantamine in aged and young Lister hooded rats.
Topics: Aging; Animals; Biological Availability; Brain; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Dose-Response Relationship, Drug; Galantamine; Half-Life; Hypothermia; Indans; Male; Metabolic Clearance Rate; Piperidines; Random Allocation; Rats; Rats, Inbred Strains; Receptor, Muscarinic M2; Salivation; Tacrine; Tears; Tremor | 2011 |
A rapid and sensitive LC-MS/MS method for quantification of donepezil and its active metabolite, 6-o-desmethyl donepezil in human plasma and its pharmacokinetic application.
Topics: Chromatography, Liquid; Donepezil; Drug Stability; Humans; Indans; Male; Piperidines; Regression Analysis; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Factors of error and effort in memory intervention for patients with Alzheimer's disease and amnesic syndrome.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amnesia; Cholinesterase Inhibitors; Cues; Donepezil; Female; Humans; Indans; Male; Mental Recall; Paired-Associate Learning; Pattern Recognition, Visual; Perceptual Masking; Piperidines | 2010 |
A case of dementia with Lewy bodies that temporarily showed symptoms similar to Creutzfeldt-Jakob disease.
Topics: Aged; Brain Ischemia; Cholinesterase Inhibitors; Creutzfeldt-Jakob Syndrome; Diagnosis, Differential; Donepezil; Hallucinations; Humans; Indans; Lewy Body Disease; Male; Mental Status Schedule; Neuropsychological Tests; Occipital Lobe; Parietal Lobe; Piperidines; Tomography, Emission-Computed, Single-Photon | 2010 |
Report of the task force on designing clinical trials in early (predementia) AD.
Topics: Advisory Committees; Alzheimer Disease; Amyloidogenic Proteins; Biomarkers; Clinical Trials as Topic; Cognition; Consensus; Disease Progression; Donepezil; Drug Industry; Early Diagnosis; Europe; Humans; Indans; International Cooperation; Nootropic Agents; Outcome Assessment, Health Care; Patient Selection; Piperidines; Positron-Emission Tomography; Research Design; Treatment Outcome; United States; United States Food and Drug Administration; Vitamin E | 2011 |
Modulatory effects of vitamin E, acetyl-L-carnitine and α-lipoic acid on new potential biomarkers for Alzheimer's disease in rat model.
Topics: Alzheimer Disease; Animals; Antioxidants; Biomarkers; Brain; Carnitine; Cholinesterase Inhibitors; Dietary Supplements; Disease Models, Animal; Donepezil; Enzyme-Linked Immunosorbent Assay; Homocysteine; Indans; Insulin-Like Growth Factor I; Interleukin-1beta; Male; Piperidines; Rats; Rats, Sprague-Dawley; Thioctic Acid; Tumor Necrosis Factor-alpha; Vitamin E | 2012 |
Insulin receptor signaling in rat hippocampus: a study in STZ (ICV) induced memory deficit model.
Topics: Animals; Blood Glucose; Chromones; Disease Models, Animal; Donepezil; Gene Expression; Hippocampus; Indans; Infusions, Intraventricular; Male; Maze Learning; Melatonin; Memory; Memory Disorders; Morpholines; Nootropic Agents; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Insulin; Signal Transduction; Streptozocin | 2011 |
Protection of cholinergic and antioxidant system contributes to the effect of berberine ameliorating memory dysfunction in rat model of streptozotocin-induced diabetes.
Topics: Acetylcholine; Administration, Oral; Analysis of Variance; Animals; Antioxidants; Ascorbic Acid; Berberine; Blood Glucose; Body Weight; Brain; Cholinesterase Inhibitors; Cholinesterases; Diabetes Mellitus, Experimental; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Exploratory Behavior; Glutathione; Hypoglycemic Agents; Indans; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Metformin; Piperidines; Rats; Rats, Wistar | 2011 |
Motor cortex excitability in Alzheimer's disease: a transcranial magnetic stimulation follow-up study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Motor Cortex; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Transcranial Magnetic Stimulation | 2011 |
Donepezil plus estradiol treatment enhances learning and delay-dependent memory performance by young ovariectomized rats with partial loss of septal cholinergic neurons.
Topics: Acetylcholine; Analysis of Variance; Animals; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Donepezil; Estradiol; Estrogens; Female; Indans; Maze Learning; Memory; Neurons; Piperidines; Rats; Rats, Sprague-Dawley; Septum of Brain | 2011 |
Donepezil attenuated oxygen-glucose deprivation insult by blocking Kv2.1 potassium channels.
Topics: Apoptosis; Cell Hypoxia; Donepezil; Dose-Response Relationship, Drug; Electric Conductivity; Electrophysiological Phenomena; Glucose; HEK293 Cells; Humans; Indans; Oxygen; Piperidines; Potassium Channel Blockers; Shab Potassium Channels; Transfection | 2011 |
Safety and tolerability of galantamine SA in dementia patients transitioned from donepezil.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Dementia; Donepezil; Galantamine; Humans; Indans; Middle Aged; Piperidines; Retrospective Studies | 2011 |
Cardio-vascular safety of acetyl cholinesterase inhibitors in patients suffering from Alzheimer's disease; factors that predict poor tolerability.
Topics: Alzheimer Disease; Cardiovascular Diseases; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Multivariate Analysis; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine | 2011 |
Donepezil inhibits diisopropylfluorophosphate-induced seizures and up-regulation of synaptotagmin 4 mRNA.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Anticonvulsants; Brain; Cholinesterase Inhibitors; Donepezil; Genes, fos; Indans; Isoflurophate; Lithium Chloride; Male; Models, Animal; Piperidines; Rats; Rats, Wistar; Receptors, Cholinergic; RNA, Messenger; Seizures; Synaptotagmins; Up-Regulation; Yawning | 2010 |
Effectiveness of adding memantine to an Alzheimer dementia treatment regimen which already includes stable donepezil therapy: a critically appraised topic.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Databases, Factual; Donepezil; Dopamine Agents; Drug Therapy, Combination; Humans; Indans; Male; Memantine; Nootropic Agents; Piperidines; Placebos; Randomized Controlled Trials as Topic; Treatment Outcome | 2011 |
Protective potential of Bacopa monniera (Brahmi) extract on aluminum induced cerebellar toxicity and associated neuromuscular status in aged rats.
Topics: Aging; Aluminum; Animals; Bacopa; Cerebellum; Donepezil; Indans; Male; Motor Activity; Neuromuscular Diseases; Nootropic Agents; Oxidative Stress; Piperidines; Plant Extracts; Rats; Rats, Wistar | 2011 |
Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).
Topics: Alzheimer Disease; Animals; Attention; Conditioning, Operant; Disease Models, Animal; Donepezil; Humans; Indans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Piperidines | 2011 |
Lewy body and parkinsonian dementia: common, but often misdiagnosed conditions: Evidence is not satisfactory.
Topics: Aged; Brain; Cholinesterase Inhibitors; Cross-Sectional Studies; Dementia; Diagnosis, Differential; Diagnostic Imaging; Donepezil; Early Diagnosis; Evidence-Based Medicine; Humans; Indans; Lewy Body Disease; Mental Disorders; Neuropsychological Tests; Parkinson Disease; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine | 2011 |
Effects of vehicles on the percutaneous absorption of donepezil hydrochloride across the excised hairless mouse skin.
Topics: Administration, Cutaneous; Animals; Donepezil; Drug Delivery Systems; Fatty Acids; Indans; Male; Mice; Mice, Hairless; Nootropic Agents; Pharmaceutical Vehicles; Piperidines; Skin; Skin Absorption | 2011 |
[Effects of early intervention with Huannao Yicong formula effective components on behavior and cholinergic system of β-amyloid precursor protein transgenic mice].
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Behavior, Animal; Cholinergic Agents; Disease Models, Animal; Donepezil; Drugs, Chinese Herbal; Early Medical Intervention; Female; Indans; Male; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nootropic Agents; Piperidines; Receptors, Neurotransmitter | 2011 |
An economic evaluation of early assessment for Alzheimer's disease in the United Kingdom.
Topics: Alzheimer Disease; Caregivers; Cognition Disorders; Cost-Benefit Analysis; Disease Progression; Donepezil; Female; Health Care Costs; Humans; Indans; Longitudinal Studies; Male; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Quality of Life; Statistics as Topic; United Kingdom | 2012 |
[Prescription differences of dementia drugs in urban and rural areas in Germany].
Topics: Aged; Alzheimer Disease; Ambulatory Care; Donepezil; Galantamine; General Practice; Germany; Humans; Indans; Medically Underserved Area; Memantine; Neuropsychiatry; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Patterns, Physicians'; Rivastigmine; Rural Population; Urban Population; Workforce | 2011 |
Acute inhibition of 11beta-hydroxysteroid dehydrogenase type-1 improves memory in rodent models of cognition.
Topics: 11-beta-Hydroxysteroid Dehydrogenase Type 1; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain; Cholinesterase Inhibitors; CREB-Binding Protein; Donepezil; Dose-Response Relationship, Drug; Electroshock; Enzyme Inhibitors; Hydrocortisone; In Vitro Techniques; Indans; Male; Memory; Mice; Mice, Inbred ICR; Microdialysis; Models, Animal; Neuropsychological Tests; Phosphorylation; Piperidines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Social Behavior | 2011 |
Pisa syndrome caused by an acetylcholinesterase inhibitor in a patient with dementia with Lewy bodies.
Topics: Aged; Cholinesterase Inhibitors; Donepezil; Dyskinesia, Drug-Induced; Female; Humans; Indans; Lewy Body Disease; Piperidines; Syndrome | 2011 |
Ameliorative effects of yokukansan on learning and memory deficits in olfactory bulbectomized mice.
Topics: Alzheimer Disease; Animals; Choline O-Acetyltransferase; Cognition Disorders; Conditioning, Psychological; Disease Models, Animal; Donepezil; Down-Regulation; Drugs, Chinese Herbal; Fear; Indans; Learning; Male; Maze Learning; Memory; Mice; Mice, Inbred Strains; Olfactory Bulb; Phytotherapy; Piperidines; Poria; Receptors, Muscarinic; Scopolamine | 2011 |
Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs.
Topics: Aging; Analysis of Variance; Animals; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Discrimination, Psychological; Disease Models, Animal; Dogs; Donepezil; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Indans; Learning Disabilities; Male; Memory Disorders; Neuropsychological Tests; Odorants; Physostigmine; Piperidines; Scopolamine | 2011 |
FDA is criticised for licensing high dose donepezil.
Topics: Alzheimer Disease; Donepezil; Dose-Response Relationship, Drug; Drug Approval; Humans; Indans; Licensure; Nootropic Agents; Piperidines; United States; United States Food and Drug Administration | 2011 |
ICV STZ induced impairment in memory and neuronal mitochondrial function: A protective role of nicotinic receptor.
Topics: Analysis of Variance; Animals; Blood Glucose; Brain; Calcium; Caspase 3; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Glutathione; Indans; Injections, Intraventricular; Male; Malondialdehyde; Maze Learning; Memory Disorders; Mitochondria; Motor Activity; Neurons; Nicotine; Piperidines; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptors, Nicotinic; Streptozocin; Tacrine | 2011 |
BCHE and CYP2D6 genetic variation in Alzheimer's disease patients treated with cholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoproteins E; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognition; Cytochrome P-450 CYP2D6; Donepezil; Female; Galantamine; Genetic Association Studies; Genetic Variation; Genotype; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Rivastigmine; Treatment Outcome | 2011 |
Bradycardia due to cholinesterase inhibitors: identify adverse effects and take them into account.
Topics: Alzheimer Disease; Bradycardia; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Risk; Rivastigmine | 2011 |
1-H MRS changes in dorsolateral prefrontal cortex after donepezil treatment in patients with mild to moderate Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cohort Studies; Donepezil; Female; Humans; Indans; Magnetic Resonance Spectroscopy; Male; Neuropsychological Tests; Piperidines; Prefrontal Cortex | 2011 |
"Reversible" Alzheimer's disease?
Topics: Aged; Alzheimer Disease; Atrophy; Cohort Studies; Combined Modality Therapy; Donepezil; Female; Fluorodeoxyglucose F18; Follow-Up Studies; Humans; Indans; Life Style; Magnetic Resonance Imaging; Male; Mental Status Schedule; Motor Activity; Neuropsychological Tests; Nootropic Agents; Piperidines; Positron-Emission Tomography; Psychometrics; Remission, Spontaneous; Temporal Lobe | 2011 |
Development and validation of a sample stabilization strategy and a UPLC-MS/MS method for the simultaneous quantitation of acetylcholine (ACh), histamine (HA), and its metabolites in rat cerebrospinal fluid (CSF).
Topics: Acetylcholine; Animals; Benzofurans; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Drug Stability; Histamine; Hydrophobic and Hydrophilic Interactions; Imidazoles; Indans; Male; Methylhistamines; Piperidines; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry | 2011 |
Donepezil-induced linear IgA disease.
Topics: Aged, 80 and over; Autoimmune Diseases; Cholinesterase Inhibitors; Donepezil; Female; Humans; Immunoglobulin A; Indans; Nootropic Agents; Piperidines | 2012 |
Relief of carotid stenosis improves impaired cognition in a rat model of chronic cerebral hypoperfusion.
Topics: Acetylcholine; Acoustic Stimulation; Analysis of Variance; Animals; Biogenic Monoamines; Brain Ischemia; Carotid Arteries; Carotid Stenosis; Cerebrovascular Circulation; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Event-Related Potentials, P300; Hippocampus; Indans; Male; Maze Learning; Microdialysis; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors | 2011 |
Donepezil, anti-Alzheimer's disease drug, prevents cardiac rupture during acute phase of myocardial infarction in mice.
Topics: Alzheimer Disease; Animals; Blood Pressure; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Electrophoresis, Polyacrylamide Gel; Heart; Heart Rate; Heart Rupture, Post-Infarction; Humans; Immunohistochemistry; Indans; Macrophages; Male; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Myocardial Infarction; Myocardium; Piperidines; Reverse Transcriptase Polymerase Chain Reaction | 2011 |
Two novel 5-HT6 receptor antagonists ameliorate scopolamine-induced memory deficits in the object recognition and object location tasks in Wistar rats.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Exploratory Behavior; Guanidines; Indans; Male; Maze Learning; Memory Disorders; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Scopolamine; Serotonin Antagonists; Sulfonamides | 2011 |
A modified formulation of Chinese traditional medicine improves memory impairment and reduces Aβ level in the Tg-APPswe/PS1dE9 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Apoptosis; Behavior, Animal; Brain; Cell Line, Tumor; Chemistry, Pharmaceutical; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Humans; Indans; Memory; Memory Disorders; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Nootropic Agents; Peptide Fragments; Phosphorylation; Piperidines; Presenilin-1; Proto-Oncogene Proteins c-akt; Reactive Oxygen Species; Time Factors | 2011 |
Recovery of hippocampal network connectivity correlates with cognitive improvement in mild Alzheimer's disease patients treated with donepezil assessed by resting-state fMRI.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cognition Disorders; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Follow-Up Studies; Hippocampus; Humans; Indans; Linear Models; Magnetic Resonance Imaging; Male; Nerve Net; Neuropsychological Tests; Piperidines; Recovery of Function; Reference Values; Severity of Illness Index; Treatment Outcome | 2011 |
Donepezil, but not galantamine, blocks muscarinic receptor-mediated in vitro and in vivo responses.
Topics: Animals; Animals, Outbred Strains; Cell Line, Tumor; Cerebral Cortex; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Galantamine; Humans; Indans; Male; Mental Disorders; Mice; Muscarinic Antagonists; Piperidines; Receptors, Muscarinic | 2011 |
Donepezil reduces cognitive impairment associated with anti-cancer drugs in a mouse model.
Topics: Analysis of Variance; Animals; Antineoplastic Combined Chemotherapy Protocols; Cognition Disorders; Cues; Disease Models, Animal; Donepezil; Female; Fluorouracil; Indans; Maze Learning; Memory; Methotrexate; Mice; Mice, Inbred BALB C; Nootropic Agents; Piperidines; Space Perception; Time Factors | 2011 |
Butyrylcholinesterase inhibitors ameliorate cognitive dysfunction induced by amyloid-β peptide in mice.
Topics: Amyloid beta-Peptides; Analysis of Variance; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Mice; Mice, Inbred ICR; Motor Activity; Peptide Fragments; Phenylcarbamates; Piperidines; Recognition, Psychology; Rivastigmine | 2011 |
Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus.
Topics: Analysis of Variance; Animals; Cholinesterase Inhibitors; Donepezil; Enzyme-Linked Immunosorbent Assay; Galantamine; Gene Expression Regulation; Hippocampus; Immunoprecipitation; Indans; Male; Mice; Mice, Inbred C57BL; Phosphorylation; Piperidines; Receptor, trkA; Receptor, trkB; Signal Transduction; Time Factors; Tyrosine | 2011 |
Disease progression and costs of care in Alzheimer's disease patients treated with donepezil: a longitudinal naturalistic cohort.
Topics: Activities of Daily Living; Aged; Alzheimer Disease; Cognition; Disease Progression; Donepezil; Female; Health Care Costs; Health Status Indicators; Humans; Indans; Institutionalization; Longitudinal Studies; Male; Models, Economic; Nootropic Agents; Piperidines; Psychometrics; Regression Analysis; Severity of Illness Index; Sweden | 2012 |
Paraoxonase 1 gene polymorphisms do not influence the response to treatment in Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Aryldialkylphosphatase; Cholinesterase Inhibitors; DNA; Donepezil; Female; Haplotypes; Heterozygote; Humans; Indans; Male; Neuropsychological Tests; Phenylcarbamates; Piperidines; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Real-Time Polymerase Chain Reaction; Rivastigmine | 2011 |
Significant dose differences in donepezil purchased from the United States and Canada.
Topics: Alzheimer Disease; Canada; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Prescription Drugs; Tablets; United States | 2011 |
Effects of cholinesterase inhibitors on postoperative outcomes of older adults with dementia undergoing hip fracture surgery.
Topics: Aged; Aged, 80 and over; Anesthesia, General; Cholinesterase Inhibitors; Cohort Studies; Critical Care; Dementia; Donepezil; Female; Galantamine; Hip Fractures; Humans; Indans; Male; Outcome and Process Assessment, Health Care; Phenylcarbamates; Piperidines; Pneumonia; Postoperative Complications; Respiratory Insufficiency; Resuscitation; Risk; Rivastigmine | 2011 |
The impact of patient and public involvement in the work of the Dementias & Neurodegenerative Diseases Research Network (DeNDRoN): case studies.
Topics: Alzheimer Disease; Biomedical Research; Community Participation; Dementia; Donepezil; Humans; Indans; Memantine; Neurodegenerative Diseases; Nootropic Agents; Organizational Case Studies; Patient Participation; Piperidines | 2013 |
SenseCam improves memory for recent events and quality of life in a patient with memory retrieval difficulties.
Topics: Cholinesterase Inhibitors; Cognitive Dysfunction; Cues; Donepezil; Environmental Monitoring; Female; Humans; Image Processing, Computer-Assisted; Indans; Medical Records; Memory Disorders; Memory, Episodic; Mental Recall; Microcomputers; Middle Aged; Nootropic Agents; Photography; Piperidines; Quality of Life; Self Report; Self-Help Devices | 2011 |
Donepezil dosing strategies: pharmacokinetic considerations.
Topics: Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Models, Theoretical; Piperidines; United States; United States Food and Drug Administration | 2011 |
Donepezil in a narrow concentration range augments control and impaired by beta-amyloid peptide hippocampal LTP in NMDAR-independent manner.
Topics: Action Potentials; Amyloid beta-Peptides; Animals; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Indans; Ion Channel Gating; Long-Term Potentiation; Male; Piperidines; Rats; Rats, Wistar; Receptors, N-Methyl-D-Aspartate; Tetanus | 2012 |
Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's di
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Binding Sites; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Isoenzymes; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Peptide Fragments; Piperidines; Rats; Structure-Activity Relationship | 2011 |
Collaborative research between academia and industry using a large clinical trial database: a case study in Alzheimer's disease.
Topics: Academies and Institutes; Alzheimer Disease; Cholinesterase Inhibitors; Cooperative Behavior; Data Mining; Databases, Factual; Donepezil; Drug Industry; Humans; Indans; Piperidines; Randomized Controlled Trials as Topic | 2011 |
Improvement of cognitive impairment following delayed CO encephalopathy.
Topics: Adolescent; Brain Diseases; Carbon Monoxide Poisoning; Cognition Disorders; Donepezil; Humans; Indans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Nootropic Agents; Piperidines | 2011 |
Effect of fatty acids on the transdermal delivery of donepezil: in vitro and in vivo evaluation.
Topics: Administration, Cutaneous; Animals; Cadaver; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Compounding; Fatty Acids, Monounsaturated; Humans; Indans; Male; Mice; Mice, Hairless; Oleic Acid; Permeability; Piperidines; Propylene Glycol; Rats; Rats, Sprague-Dawley; Skin; Skin Absorption; Solubility; Solvents; Technology, Pharmaceutical | 2012 |
Delusional parasitosis associated with donepezil.
Topics: Aged; Cognition Disorders; Delusions; Donepezil; Dose-Response Relationship, Drug; Ectoparasitic Infestations; Humans; Indans; Male; Nootropic Agents; Piperidines | 2011 |
EVP-6124, a novel and selective α7 nicotinic acetylcholine receptor partial agonist, improves memory performance by potentiating the acetylcholine response of α7 nicotinic acetylcholine receptors.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Partial Agonism; Indans; Male; Memory; Nicotinic Agonists; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Nicotinic; Thiophenes | 2012 |
A novel injectable in situ forming poly-DL-lactide and DL-lactide/glycolide implant containing lipospheres for controlled drug delivery.
Topics: Donepezil; Drug Delivery Systems; Indans; Lactic Acid; Liposomes; Piperidines; Polyesters; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer | 2012 |
Evaluation of therapeutic response to donepezil by positron emission tomography.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Chi-Square Distribution; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Monitoring; Female; Fluorodeoxyglucose F18; Glucose; Humans; Indans; Japan; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Positron-Emission Tomography; Predictive Value of Tests; Radiopharmaceuticals; Severity of Illness Index; Time Factors; Treatment Outcome | 2011 |
Isoflurane-induced spatial memory impairment in mice is prevented by the acetylcholinesterase inhibitor donepezil.
Topics: Acetylcholinesterase; Anesthetics, Inhalation; Animals; Blood Gas Analysis; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Indans; Isoflurane; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Piperidines | 2011 |
ESI-MS/MS stability-indicating bioanalytical method development and validation for simultaneous estimation of donepezil, 5-desmethyl donepezil and 6-desmethyl donepezil in human plasma.
Topics: Area Under Curve; Chromatography, Liquid; Donepezil; Drug Stability; Humans; Indans; Least-Squares Analysis; Male; Piperidines; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2012 |
AChE inhibitor: a regio- and stereo-selective 1,3-dipolar cycloaddition for the synthesis of novel substituted 5,6-dimethoxy spiro[5.3']-oxindole-spiro-[6.3″]-2,3-dihydro-1H-inden-1″-one-7-(substituted aryl)-tetrahydro-1H-pyrrolo[1,2-c][1,3]thiazole.
Topics: Acetylcholinesterase; Alzheimer Disease; Azo Compounds; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Indoles; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Models, Molecular; Molecular Conformation; Piperidines; Spiro Compounds; Structure-Activity Relationship; Temperature; Thiazoles; Thiosemicarbazones; Triazoles | 2012 |
Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis.
Topics: Anticholesteremic Agents; Atorvastatin; Catalysis; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Drug Design; Flavones; Halogenation; Heptanoic Acids; Indans; Isomerism; Light; Methylation; Molecular Structure; Oxidation-Reduction; Pharmaceutical Preparations; Photochemical Processes; Piperidines; Pyrroles; Uracil | 2011 |
Characterization of oral disintegrating film containing donepezil for Alzheimer disease.
Topics: Administration, Oral; Alzheimer Disease; Chemistry, Pharmaceutical; Donepezil; Double-Blind Method; Drug Carriers; Female; Humans; Indans; Male; Piperidines; Solubility; Sweetening Agents; Taste; Tensile Strength; Young Adult | 2012 |
Reversible and persistent decreases in cocaine self-administration after cholinesterase inhibition: different effects of donepezil and rivastigmine.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cocaine; Donepezil; Dopamine Uptake Inhibitors; Female; Indans; Male; Phenylcarbamates; Piperidines; Rats; Rats, Wistar; Reinforcement, Psychology; Rivastigmine; Self Administration | 2011 |
Unemployment in multiple sclerosis: the contribution of personality and disease.
Topics: Adult; Affect; Chi-Square Distribution; Cognition; Cognition Disorders; Cost of Illness; Cross-Sectional Studies; Disability Evaluation; Donepezil; Fatigue; Female; Humans; Indans; Learning; Logistic Models; Male; Memory; Middle Aged; Multiple Sclerosis; Neuropsychological Tests; New York; Nootropic Agents; Personality; Piperidines; Predictive Value of Tests; Randomized Controlled Trials as Topic; Retrospective Studies; Risk Assessment; Risk Factors; Severity of Illness Index; Surveys and Questionnaires; Time Factors; Unemployment | 2012 |
Determination of donepezil hydrochloride in human plasma and pharmaceutical formulations by HPLC with fluorescence detection.
Topics: Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Liquid; Donepezil; Humans; Indans; Male; Micelles; Piperidines; Spectrometry, Fluorescence | 2011 |
Re: stereopsis in drug Naïve parkinson's disease patients.
Topics: Brain; Cholinesterases; Depth Perception; Donepezil; Humans; Indans; Nootropic Agents; Parkinson Disease; Piperidines; Proto-Oncogene Proteins c-bcl-2; Up-Regulation | 2011 |
Implementation of a cost-effective HPLC/UV-approach for medical routine quantification of donepezil in human serum.
Topics: Chromatography, High Pressure Liquid; Dementia; Donepezil; Drug Monitoring; Drug Stability; Humans; Indans; Linear Models; Piperidines; Polypharmacy; Reproducibility of Results; Sensitivity and Specificity; Solid Phase Extraction; Spectrophotometry, Ultraviolet | 2012 |
Is donepezil effective for multiple sclerosis-related cognitive dysfunction? A critically appraised topic.
Topics: Cognition Disorders; Donepezil; Humans; Indans; Memory; Multiple Sclerosis; Nootropic Agents; Piperidines; Treatment Outcome | 2012 |
Toxicity and efficacy of the acetylcholinesterase (AChe) inhibitor donepezil in childhood brain tumor survivors: a pilot study.
Topics: Adolescent; Adult; Antineoplastic Agents; Brain Neoplasms; Child; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Executive Function; Female; Humans; Indans; Male; Memory; Neuropsychological Tests; Pilot Projects; Piperidines; Survivors; Treatment Outcome | 2012 |
Effectiveness of a high-throughput genetic analysis in the identification of responders/non-responders to CYP2D6-metabolized drugs.
Topics: Alleles; Alzheimer Disease; Biotransformation; Cytochrome P-450 CYP2D6; Donepezil; Drug Resistance; Gene Deletion; Gene Duplication; Gene Frequency; Genotype; High-Throughput Nucleotide Sequencing; Humans; Indans; Nootropic Agents; Piperidines; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Sampling Studies; Single-Blind Method | 2011 |
Donepezil attenuates hippocampal neuronal damage and cognitive deficits after global cerebral ischemia in gerbils.
Topics: Animals; Brain Ischemia; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Death; Cognition Disorders; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Donepezil; Gerbillinae; Hippocampus; Indans; Male; Maze Learning; Memory; Memory Disorders; Neurons; Neuroprotective Agents; Piperidines; Signal Transduction | 2012 |
Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Excitatory Postsynaptic Potentials; Hippocampus; Indans; Long-Term Potentiation; Male; Phosphodiesterase Inhibitors; Piperidines; Pyrazoles; Pyrimidines; Rats; Rats, Wistar | 2012 |
Changes in regional cerebral blood flow and functional connectivity in the cholinergic pathway associated with cognitive performance in subjects with mild Alzheimer's disease after 12-week donepezil treatment.
Topics: Aged; Alzheimer Disease; Cerebrovascular Circulation; Cholinergic Fibers; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Female; Humans; Indans; Male; Neural Pathways; Piperidines; Regional Blood Flow; Severity of Illness Index; Time Factors | 2012 |
Withdrawal syndrome after donepezil cessation in a patient with dementia.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Delirium; Dementia; Donepezil; Female; Humans; Indans; Middle Aged; Piperidines; Substance Withdrawal Syndrome; Withholding Treatment | 2012 |
[Shortening of donepezil-induced QTc prolongation with a change in the interacting drug, after electrocardiograph monitoring by community pharmacists: a case report].
Topics: Aged, 80 and over; Amlodipine; Cholinesterase Inhibitors; Community Pharmacy Services; Dihydropyridines; Donepezil; Drug Interactions; Electrocardiography, Ambulatory; Female; Humans; Indans; Pharmacists; Piperidines; Risk; Risk Management; Torsades de Pointes | 2012 |
Memory defect induced by β-amyloid plus glutamate receptor agonist is alleviated by catalpol and donepezil through different mechanisms.
Topics: Amyloid beta-Peptides; Animals; Cells, Cultured; Donepezil; Excitatory Amino Acid Agonists; Female; Indans; Iridoid Glucosides; Memory Disorders; Mice; Mice, Inbred ICR; Peptide Fragments; Piperidines; Protein Binding; Random Allocation; Receptors, Glutamate | 2012 |
Donepezil protects endothelial cells against hydrogen peroxide-induced cell injury.
Topics: Cell Survival; Cells, Cultured; Cytoprotection; Donepezil; Endothelial Cells; Endothelium, Vascular; Human Umbilical Vein Endothelial Cells; Humans; Hydrogen Peroxide; Indans; Piperidines | 2012 |
Evaluating the cost effectiveness of donepezil in the treatment of Alzheimer's disease in Germany using discrete event simulation.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cost-Benefit Analysis; Donepezil; Dopamine Agents; Germany; Humans; Indans; Memantine; Piperidines; Quality-Adjusted Life Years | 2012 |
Synergistic effect of acetylcholinesterase inhibition (donepezil) and 5-HT(4) receptor activation (RS67333) on object recognition in mice.
Topics: Analysis of Variance; Aniline Compounds; Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Indans; Indoles; Male; Mice; Piperidines; Recognition, Psychology; Serotonin Antagonists; Serotonin Receptor Agonists; Sulfonamides | 2012 |
Pisa syndrome secondary to rivastigmine: a case report.
Topics: Aged; Benzodiazepines; Cholinesterase Inhibitors; Delusions; Dementia; Donepezil; Humans; Indans; Male; Movement Disorders; Olanzapine; Phenylcarbamates; Piperidines; Posture; Rivastigmine; Syndrome | 2012 |
Acetylcholinesterase inhibitors attenuate angiogenesis.
Topics: Acetylcholine; Animals; Cells, Cultured; Cholinesterase Inhibitors; Chromones; Donepezil; Hindlimb; Indans; Interleukin-1beta; Ischemia; Mice; Mice, Inbred C57BL; Morpholines; Neovascularization, Pathologic; Neovascularization, Physiologic; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Proto-Oncogene Proteins c-akt; Vascular Endothelial Growth Factor A | 2012 |
Use of clarithromycin and adverse cardiovascular events among older patients receiving donepezil: a population-based, nested case-control study.
Topics: Aged; Aged, 80 and over; Anti-Bacterial Agents; Atrioventricular Block; Bradycardia; Cardiovascular Diseases; Case-Control Studies; Cholinesterase Inhibitors; Clarithromycin; Cohort Studies; Cytochrome P-450 CYP3A Inhibitors; Donepezil; Drug Interactions; Drug Prescriptions; Enzyme Inhibitors; Female; Humans; Indans; Macrolides; Male; Ontario; Piperidines; Syncope | 2012 |
[Pilot study of dementia medication compliance conducted among pharmacists providing home visits which evaluates the degree of drug compliance, as defined by numerous attributes, between patients at home and patients in a medical facility].
Topics: Activities of Daily Living; Cognition; Dementia; Donepezil; Health Facilities; House Calls; Humans; Indans; Nootropic Agents; Patient Care Management; Patient Compliance; Pharmacists; Pilot Projects; Piperidines; Professional Role | 2012 |
Discontinuing donepezil or starting memantine for Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Excitatory Amino Acid Antagonists; Female; Humans; Indans; Male; Memantine; Piperidines | 2012 |
Simultaneous determination of antidementia drugs in human plasma: procedure transfer from HPLC-MS to UPLC-MS/MS.
Topics: Chromatography, High Pressure Liquid; Donepezil; Drug Stability; Galantamine; Humans; Indans; Memantine; Nootropic Agents; Phenethylamines; Phenols; Phenylcarbamates; Piperidines; Plasma; Reference Standards; Reproducibility of Results; Rivastigmine; Tandem Mass Spectrometry | 2012 |
Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Indans; Male; Maze Learning; Memantine; Memory; Mice; Mice, Transgenic; Motor Activity; Piperidines; Rest; Spatial Behavior | 2012 |
How the FDA forgot the evidence: the case of donepezil 23 mg.
Topics: Alzheimer Disease; Donepezil; Drug Approval; Drug Labeling; Evidence-Based Medicine; Humans; Indans; Marketing; Nootropic Agents; Piperidines; United States; United States Food and Drug Administration | 2012 |
Case report: Post-traumatic memories triggered by donepezil in a dose-dependent pattern.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Memory, Episodic; Piperidines; Stress Disorders, Post-Traumatic | 2012 |
Bacopa monnieri increases cerebral blood flow in rat independent of blood pressure.
Topics: Animals; Bacopa; Blood Pressure; Cerebrovascular Circulation; Donepezil; Ginkgo biloba; Indans; Male; Nitroprusside; Nootropic Agents; Norepinephrine; Piperidines; Plant Extracts; Rats | 2013 |
Antioxidant enzymatic activities in Alzheimer's disease: the relationship to acetylcholinesterase inhibitors.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Catalase; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Glutathione Reductase; Humans; Indans; Male; Oxidative Stress; Phenylcarbamates; Piperidines; Rivastigmine | 2012 |
Replication study to confirm the role of CYP2D6 polymorphism rs1080985 on donepezil efficacy in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cytochrome P-450 CYP2D6; DNA Replication; Donepezil; Female; Follow-Up Studies; Genetic Markers; Humans; Indans; Male; Piperidines; Polymorphism, Genetic; Treatment Outcome | 2012 |
Acetylcholinesterase inhibitors and the risk of hip fracture in Alzheimer's disease patients: a case-control study.
Topics: Acetylcholinesterase; Aged; Aged, 80 and over; Alzheimer Disease; Body Mass Index; Case-Control Studies; Cholinesterase Inhibitors; Donepezil; Female; Hip Fractures; Humans; Indans; Male; Odds Ratio; Phenylcarbamates; Piperidines; Regression Analysis; Risk; Rivastigmine | 2012 |
A study on neuroinflammatory marker in brain areas of okadaic acid (ICV) induced memory impaired rats.
Topics: Animals; Behavior, Animal; Biomarkers; Blotting, Western; Donepezil; Excitatory Amino Acid Antagonists; Indans; Inflammation; Injections, Intraventricular; Interleukin-1beta; Male; Maze Learning; Memantine; Memory Disorders; Motor Activity; Nitrate Reductase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Nitrites; Nootropic Agents; Okadaic Acid; Piperidines; Polymerase Chain Reaction; Rats; Rats, Sprague-Dawley; Reactive Nitrogen Species; RNA, Messenger; Tumor Necrosis Factor-alpha | 2012 |
Working memory in the aged Ts65Dn mouse, a model for Down syndrome.
Topics: Aging; Animals; Antidepressive Agents; Central Nervous System Stimulants; Cognition; Conditioning, Operant; Dextroamphetamine; Donepezil; Dose-Response Relationship, Drug; Down Syndrome; Indans; Longitudinal Studies; Male; Memantine; Memory, Short-Term; Mice; Mice, Neurologic Mutants; Nootropic Agents; Piperidines; Psychomotor Performance; Rolipram | 2012 |
Effects of Gossypium herbaceam extract administration on the learning and memory function in the naturally aged rats: neuronal niche improvement.
Topics: Aging; Analysis of Variance; Animals; Avoidance Learning; Behavior, Animal; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Glutathione Peroxidase; Gossypium; Hippocampus; Indans; Learning Disabilities; Male; Malondialdehyde; Maze Learning; Memory Disorders; Nerve Growth Factor; Phosphopyruvate Hydratase; Phytotherapy; Piperidines; Plant Preparations; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Reaction Time; Superoxide Dismutase | 2012 |
Effects of AZD3480, a neuronal nicotinic acetylcholine receptor agonist, and donepezil on dizocilpine-induced attentional impairment in rats.
Topics: Animals; Attention Deficit Disorder with Hyperactivity; Behavior, Animal; Disease Models, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Female; Indans; Molecular Structure; Neurons; Nicotinic Agonists; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Signal Detection, Psychological | 2012 |
GOOD or BAD responder? Behavioural and neuroanatomical markers of clinical response to donepezil in dementia.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Biomarkers; Brain; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Magnetic Resonance Imaging; Male; Neuropsychological Tests; Piperidines; Treatment Outcome | 2012 |
Synthesis of new indole derivatives structurally related to donepezil and their biological evaluation as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Animals; Binding Sites; Brain; Cholinesterase Inhibitors; Donepezil; Indans; Indoles; Kinetics; Magnetic Resonance Spectroscopy; Male; Models, Molecular; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Structure-Activity Relationship | 2012 |
Gintonin, a ginseng-derived lysophosphatidic acid receptor ligand, attenuates Alzheimer's disease-related neuropathies: involvement of non-amyloidogenic processing.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Analysis of Variance; Animals; Brain; Calcium; Calcium-Binding Proteins; Cell Survival; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Egtazic Acid; Enzyme Inhibitors; Glycoproteins; Humans; Indans; Isoxazoles; Ligands; Maze Learning; Memory Disorders; Metalloproteases; Mice; Mice, Transgenic; Microfilament Proteins; Mutation; Neuroblastoma; Nootropic Agents; Panax; Peptide Fragments; Phytotherapy; Piperidines; Plant Proteins; Presenilin-1; Propionates; Protein Binding; Receptors, Lysophosphatidic Acid; Signal Transduction; Time Factors; Transfection | 2012 |
Successful treatment of musical hallucinations with the acetylcholinesterase inhibitor donepezil.
Topics: Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Female; Hallucinations; Humans; Indans; Music; Piperidines; Presbycusis; Severity of Illness Index; Treatment Outcome; Widowhood | 2012 |
Which cholinesterase inhibitor is the safest for the heart in elderly patients with Alzheimer's disease?
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Blood Pressure; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Heart; Humans; Indans; Male; Phenylcarbamates; Piperidines; Rivastigmine | 2012 |
Chiral HPLC analysis of donepezil, 5-O-desmethyl donepezil and 6-O-desmethyl donepezil in culture medium: application to fungal biotransformation studies.
Topics: Beauveria; Biotransformation; Chromatography, High Pressure Liquid; Culture Media; Cunninghamella; Donepezil; Indans; Molecular Structure; Piperidines; Stereoisomerism | 2012 |
The nicotinic α7 receptor agonist GTS-21 improves cognitive performance in ketamine impaired rhesus monkeys.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Benzylidene Compounds; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Indans; Ketamine; Macaca mulatta; Male; Molecular Targeted Therapy; Nicotinic Agonists; Nootropic Agents; Piperidines; Psychomotor Performance; Pyridines; Receptors, N-Methyl-D-Aspartate; Receptors, Nicotinic; Schizophrenia | 2013 |
Influences of donepezil on cardiovascular system--possible therapeutic benefits for heart failure--donepezil cardiac test registry (DOCTER) study.
Topics: Aged; Aged, 80 and over; Cardiovascular Physiological Phenomena; Donepezil; Female; Follow-Up Studies; Heart Diseases; Heart Failure; Humans; Indans; Male; Piperidines; Prospective Studies; Registries; Treatment Outcome | 2012 |
Novel object recognition as a facile behavior test for evaluating drug effects in AβPP/PS1 Alzheimer's disease mouse model.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Female; Humans; Indans; Male; Maze Learning; Mice; Mice, Inbred C57BL; Mice, Transgenic; Naltrexone; Pattern Recognition, Visual; Piperidines; Presenilin-1; Random Allocation | 2012 |
Cautious notification and continual monitoring of patients with mild cognitive impairment.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Dysfunction; Combined Modality Therapy; Donepezil; Health Behavior; Humans; Indans; Japan; Life Style; Middle Aged; Nootropic Agents; Patient Education as Topic; Physician-Patient Relations; Piperidines; Treatment Outcome; Truth Disclosure | 2012 |
[Interaction of donepezil with rocuronium].
Topics: Alzheimer Disease; Androstanols; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Humans; Indans; Neuromuscular Nondepolarizing Agents; Piperidines; Rocuronium | 2012 |
Okadaic acid induced neurotoxicity leads to central cholinergic dysfunction in rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Biomarkers; Donepezil; Gene Expression Regulation; Hippocampus; Indans; Male; Memantine; Memory Disorders; Motor Activity; Neurons; Neurotoxins; Okadaic Acid; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic; RNA, Messenger | 2012 |
[Donepezil].
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines | 2011 |
Toxic interaction between fluoxetine and donepezil: a case of cholinergic toxidrome.
Topics: Aged; Antidepressive Agents, Second-Generation; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Fluoxetine; Humans; Indans; Male; Piperidines | 2012 |
Combination therapy no advantage in Alzheimer's treatment.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dopamine Agents; Drug Therapy, Combination; Humans; Indans; Memantine; Piperidines | 2012 |
[Instrumental ADL and basic ADL].
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Piperidines | 2011 |
Continuing donepezil produces cognitive benefits in Alzheimer's.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neuropsychological Tests; Piperidines; Randomized Controlled Trials as Topic | 2012 |
Combined administration of cerebrolysin and donepezil induces plastic changes in prefrontal cortex in aged mice.
Topics: Aging; Amino Acids; Animals; Dendritic Spines; Donepezil; Drug Synergism; Indans; Male; Mice; Motor Activity; Neuronal Plasticity; Nootropic Agents; Piperidines; Prefrontal Cortex; Pyramidal Cells | 2012 |
Cholinergic deficit and response to donepezil therapy in Parkinson's disease with dementia.
Topics: Aged; Antiparasitic Agents; Brain Mapping; Case-Control Studies; Cholinergic Agents; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Parkinson Disease; Piperidines; Positron-Emission Tomography | 2012 |
Electron density study of the anti-Alzheimer's disease drug donepezil from conventional x-ray data and invariom database application.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Databases, Factual; Donepezil; Electrons; Humans; Indans; Molecular Conformation; Piperidines; Static Electricity; X-Ray Diffraction | 2012 |
Donepezil effects on hippocampal and prefrontal functional connectivity in Alzheimer's disease: preliminary report.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Functional Laterality; Hippocampus; Humans; Image Processing, Computer-Assisted; Indans; Magnetic Resonance Imaging; Male; Middle Aged; Neural Pathways; Nootropic Agents; Piperidines; Prefrontal Cortex | 2012 |
Administration of donepezil does not rescue galanin-induced spatial learning deficits.
Topics: Analysis of Variance; Animals; Disease Models, Animal; Donepezil; Galanin; Indans; Learning Disabilities; Male; Maze Learning; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Space Perception | 2012 |
Biodegradable donepezil lipospheres for depot injection: optimization and in-vivo evaluation.
Topics: Animals; Chromatography, Liquid; Delayed-Action Preparations; Donepezil; Drug Delivery Systems; Indans; Injections, Intramuscular; Injections, Subcutaneous; Lipids; Male; Microspheres; Nootropic Agents; Particle Size; Piperidines; Rabbits; Tandem Mass Spectrometry; Time Factors; Triglycerides | 2012 |
Cholinergic gating of hippocampal auditory evoked potentials in freely moving rats.
Topics: Alzheimer Disease; Animals; Behavior, Animal; Biperiden; Cholinergic Neurons; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Electroencephalography; Evoked Potentials, Auditory; Hippocampus; Indans; Male; Muscarinic Antagonists; Nerve Tissue Proteins; Piperidines; Rats; Rats, Wistar; Receptor, Muscarinic M1; Schizophrenia; Scopolamine; Sensory Gating | 2013 |
Efficacy of a high dosage of donepezil for Alzheimer's disease as examined by single-photon emission computed tomography imaging.
Topics: Aged; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2012 |
Delayed onset and prolonged interictal delirium following electroconvulsive therapy.
Topics: Cholinesterase Inhibitors; Delirium; Depressive Disorder; Donepezil; Electroconvulsive Therapy; Follow-Up Studies; Haloperidol; Humans; Hypnotics and Sedatives; Indans; Lorazepam; Male; Middle Aged; Piperidines; Risk Factors; Time Factors | 2012 |
Participation of antioxidant and cholinergic system in protective effect of naringenin against type-2 diabetes-induced memory dysfunction in rats.
Topics: Animals; Antioxidants; Blood Glucose; Body Weight; Cholinesterase Inhibitors; Cholinesterases; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Dietary Fats; Donepezil; Estrogen Antagonists; Fat Emulsions, Intravenous; Flavanones; Glutathione; Hypoglycemic Agents; Indans; Lipid Peroxidation; Male; Memory Disorders; Nitric Oxide; Parasympathetic Nervous System; Pioglitazone; Piperidines; Rats; Rats, Sprague-Dawley; Recognition, Psychology; Thiazolidinediones | 2012 |
Expression of APP, BACE1, AChE and ChAT in an AD model in rats and the effect of donepezil hydrochloride treatment.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Animals; Aspartic Acid Endopeptidases; Catalase; Choline O-Acetyltransferase; Disease Models, Animal; Donepezil; Glutathione Peroxidase; Hippocampus; Indans; Learning; Male; Memory; Piperidines; Rats; Rats, Sprague-Dawley | 2012 |
Structures of human acetylcholinesterase in complex with pharmacologically important ligands.
Topics: Acetylcholinesterase; Acetylthiocholine; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Humans; Indans; Models, Molecular; Piperidines; Protein Conformation; Torpedo | 2012 |
Acute Pisa syndrome after administration of a single dose of donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dystonia; Female; Humans; Indans; Memory Disorders; Piperidines; Postural Balance; Sensation Disorders | 2012 |
Donepezil-induced mania.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Mental Disorders; Middle Aged; Piperidines | 2012 |
Dalfampridine: is the seizure risk greater than previously thought?
Topics: 4-Aminopyridine; Donepezil; Follow-Up Studies; Humans; Indans; Middle Aged; Multiple Sclerosis; Piperidines; Potassium Channel Blockers; Risk Assessment; Seizures; Severity of Illness Index | 2013 |
Cervical dystonia in an Alzheimer's disease patient treated with donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Piperidines; Torticollis | 2013 |
Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: synthesis, biological assessment, and molecular modeling.
Topics: Acetylcholinesterase; Alzheimer Disease; Aminopyridines; Binding Sites; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Enzyme Assays; Humans; Indans; Models, Biological; Models, Molecular; Nitriles; Permeability; Piperidines; Protein Binding; Pyridines; Structure-Activity Relationship | 2012 |
Lancemaside A isolated from Codonopsis lanceolata and its metabolite echinocystic acid ameliorate scopolamine-induced memory and learning deficits in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cholinesterase Inhibitors; Codonopsis; Cyclic AMP Response Element-Binding Protein; Donepezil; Dose-Response Relationship, Drug; Indans; Intestinal Mucosa; Intestines; Learning Disabilities; Male; Maze Learning; Memory; Memory Disorders; Mice; Mice, Inbred ICR; Oleanolic Acid; Phytotherapy; Piperidines; Plant Extracts; Rhizome; Scopolamine | 2012 |
A new combination MALDI matrix for small molecule analysis: application to imaging mass spectrometry for drugs and metabolites.
Topics: Animals; Brain; Donepezil; Indans; Male; Mice; Molecular Imaging; Piperidines; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2012 |
[Drug induced parkinsonism].
Topics: Antipsychotic Agents; Benzamides; Butyrophenones; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Parkinsonian Disorders; Phenothiazines; Piperidines | 2012 |
Positive allosteric modulator of α7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates.
Topics: Allosteric Regulation; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Drug Therapy, Combination; Female; Indans; Isoxazoles; Learning; Macaca mulatta; Male; Memory; Phenylurea Compounds; Piperidines; Rats; Rats, Inbred F344; Rats, Sprague-Dawley; Receptors, Nicotinic; Species Specificity; Treatment Outcome; Up-Regulation | 2013 |
Comparative cardiovascular safety of dementia medications: a cross-national study.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cohort Studies; Dementia; Denmark; Donepezil; Female; Heart Failure; Humans; Indans; Male; Medicare; Memantine; Myocardial Infarction; Nootropic Agents; Piperidines; Receptors, N-Methyl-D-Aspartate; United States | 2012 |
Donepezil induced antecollis in a patient with Parkinson's disease dementia.
Topics: Aged; Cholinesterase Inhibitors; Dementia; Donepezil; Dyskinesia, Drug-Induced; Female; Humans; Indans; Neck Muscles; Parkinson Disease; Piperidines; Posture | 2013 |
[Why choose another cholinesterase inhibitor than donepezil?].
Topics: Cholinesterase Inhibitors; Conflict of Interest; Donepezil; Drug Costs; Humans; Indans; Lewy Body Disease; Neuropsychological Tests; Piperidines | 2012 |
Genetic testing in combination with preventive donepezil treatment for patients with amnestic mild cognitive impairment: an exploratory economic evaluation of personalized medicine.
Topics: Aged; Aged, 80 and over; Amnesia; Canada; Case-Control Studies; Chemoprevention; Cognitive Dysfunction; Cost-Benefit Analysis; Donepezil; Genetic Testing; Humans; Indans; Markov Chains; Molecular Targeted Therapy; Nootropic Agents; Piperidines; Precision Medicine; Quality-Adjusted Life Years; Severity of Illness Index; Standard of Care | 2012 |
Effect of angiotensin II on spatial memory, cerebral blood flow, cholinergic neurotransmission, and brain derived neurotrophic factor in rats.
Topics: Acetylcholine; Acetylcholinesterase; Adenosine Triphosphate; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Biphenyl Compounds; Brain-Derived Neurotrophic Factor; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Hippocampus; Imidazoles; Indans; Male; Melatonin; Memory; Oxidative Stress; Piperidines; Pyridines; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Tetrazoles | 2013 |
Application of the VSRAD, a specific and sensitive voxel-based morphometry, to comparison of entorhinal cortex atrophy between dementia with Lewy bodies and Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Data Interpretation, Statistical; Donepezil; Entorhinal Cortex; Female; Humans; Image Processing, Computer-Assisted; Indans; Lewy Body Disease; Magnetic Resonance Imaging; Male; Nootropic Agents; Piperidines; Sex Characteristics | 2012 |
Endogenous acetylcholine rescues NMDA-induced long-lasting hippocampal cell damage via stimulation of muscarinic M(1) receptors: elucidation using organic hippocampal slice cultures.
Topics: Acetylcholine; Animals; Blotting, Western; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Galantamine; Hippocampus; Indans; Mice; Mice, Inbred ICR; N-Methylaspartate; Organ Culture Techniques; Piperidines; Receptor, Muscarinic M1; Tacrine | 2013 |
Relief of hypersensitivity after nerve injury from systemic donepezil involves spinal cholinergic and γ-aminobutyric acid mechanisms.
Topics: Animals; Atropine; Bicuculline; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; GABA Agents; GABA Antagonists; GABA-A Receptor Antagonists; gamma-Aminobutyric Acid; Indans; Male; Mecamylamine; Neuralgia; Nicotinic Antagonists; Organophosphorus Compounds; Parasympatholytics; Peripheral Nerve Injuries; Piperidines; Rats; Rats, Sprague-Dawley; Spinal Nerves | 2013 |
Donepezil is ineffective in promoting motor and cognitive benefits after controlled cortical impact injury in male rats.
Topics: Animals; Brain Injuries; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Piperidines; Rats; Rats, Sprague-Dawley; Recovery of Function | 2013 |
[Determination of donepezil enantiomer in human plasma by normal-HPLC-MS/MS].
Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Piperidines; Stereoisomerism; Tandem Mass Spectrometry | 2012 |
Donepezil, an acetylcholinesterase inhibitor, attenuates nicotine self-administration and reinstatement of nicotine seeking in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Cholinesterase Inhibitors; Conditioning, Operant; Cues; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Nicotine; Piperidines; Rats; Reinforcement Schedule; Reinforcement, Psychology; Self Administration; Sucrose; Tobacco Use Disorder | 2014 |
Donepezil in low micromolar concentrations modulates voltage-gated potassium currents in pyramidal neurons of rat hippocampus.
Topics: Animals; Cells, Cultured; Cholinesterase Inhibitors; Delayed Rectifier Potassium Channels; Donepezil; Hippocampus; Indans; Patch-Clamp Techniques; Piperidines; Pyramidal Cells; Rats | 2013 |
Diverse age-related effects of Bacopa monnieri and donepezil in vitro on cytokine production, antioxidant enzyme activities, and intracellular targets in splenocytes of F344 male rats.
Topics: Aging; Animals; Bacopa; Cell Proliferation; Cells, Cultured; Cytokines; Donepezil; Enzyme Activation; Gene Expression Regulation; Humans; Immunity, Cellular; In Vitro Techniques; Indans; Intracellular Signaling Peptides and Proteins; Male; Medicine, Ayurvedic; Nervous System Diseases; Oxidative Stress; Piperidines; Rats; Rats, Inbred F344; Signal Transduction; Spleen; T-Lymphocytes | 2013 |
Donepezil abolishes anticholinergic activity in a patient with amnesia.
Topics: Aged; Amnesia; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Female; Humans; Indans; Nootropic Agents; Piperidines | 2013 |
Design, synthesis and evaluation of novel heterodimers of donepezil and huperzine fragments as acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alkaloids; Animals; Cholinesterase Inhibitors; Dimerization; Donepezil; Dose-Response Relationship, Drug; Drug Design; Indans; Molecular Structure; Piperidines; Rats; Rats, Sprague-Dawley; Sesquiterpenes; Structure-Activity Relationship | 2013 |
Characterization of cognitive deficits in a transgenic mouse model of Alzheimer's disease and effects of donepezil and memantine.
Topics: Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Donepezil; Female; Indans; Maze Learning; Memantine; Memory; Memory Disorders; Mice; Mice, Transgenic; Nootropic Agents; Piperidines; Receptors, AMPA | 2013 |
Donepezil-induced sleep spindle in a patient with dementia with Lewy bodies: a case report.
Topics: Aged, 80 and over; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Lewy Body Disease; Piperidines; Polysomnography; Psychiatric Status Rating Scales; REM Sleep Behavior Disorder; Sleep, REM; Treatment Outcome | 2012 |
Nobiletin-rich Citrus reticulata peels, a kampo medicine for Alzheimer's disease: a case series.
Topics: Aged; Alzheimer Disease; Antioxidants; Chromatography, High Pressure Liquid; Citrus; Disease Progression; Donepezil; Flavones; Humans; Indans; Japan; Medicine, Kampo; Phytotherapy; Piperidines; Statistics, Nonparametric; Treatment Outcome | 2013 |
Paeoniflorin attenuates amyloid-beta peptide-induced neurotoxicity by ameliorating oxidative stress and regulating the NGF-mediated signaling in rats.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Catalase; Choline O-Acetyltransferase; Donepezil; Glucosides; Hippocampus; Indans; Male; Malondialdehyde; Matrix Metalloproteinase 9; Maze Learning; Monoterpenes; Nerve Growth Factor; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Peptide Fragments; Piperidines; Random Allocation; Rats, Sprague-Dawley; Receptor, trkA; Spatial Memory; Superoxide Dismutase; Tissue Inhibitor of Metalloproteinase-1 | 2013 |
Preparation, characterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded PLGA nanoparticles for brain targeting.
Topics: Animals; Brain; Donepezil; Drug Delivery Systems; Indans; Lactic Acid; Nanoparticles; Particle Size; Piperidines; Polyglycolic Acid; Polylactic Acid-Polyglycolic Acid Copolymer; Rats; Rats, Sprague-Dawley; Tissue Distribution | 2014 |
Trace analysis of acetylcholinesterase inhibitors with antipsychotic drugs for Alzheimer's disease by capillary electrophoresis with on column field-amplified sample injection.
Topics: Alzheimer Disease; Antipsychotic Agents; Cholinesterase Inhibitors; Donepezil; Electrophoresis, Capillary; Humans; Indans; Phenylcarbamates; Piperidines; Rivastigmine | 2013 |
Okadaic acid-induced Tau phosphorylation in rat brain: role of NMDA receptor.
Topics: Animals; Brain; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calpain; Cholinergic Antagonists; Dizocilpine Maleate; Donepezil; Enzyme Inhibitors; Excitatory Amino Acid Antagonists; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indans; Male; Maze Learning; Memantine; Neurons; Okadaic Acid; Phosphoprotein Phosphatases; Phosphorylation; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; tau Proteins | 2013 |
[Anticholinesterases; peripheral and central effects].
Topics: Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neostigmine; Neuromuscular Blocking Agents; Neuromuscular Junction; Piperidines | 2013 |
Is drug treatment for dementia followed up in primary care? A Swedish study of dementia clinics and referring primary care centres.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Dementia; Dementia, Vascular; Donepezil; Female; Galantamine; Humans; Indans; Male; Medical Records; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Practice Patterns, Physicians'; Primary Health Care; Retrospective Studies; Rivastigmine; Sweden; Treatment Outcome | 2013 |
Effects of cholinesterase inhibitors and serotonin-1A receptor agonists on morphine-induced ventilatory depression and antinociception in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Analgesia; Animals; Buspirone; Cholinesterase Inhibitors; Donepezil; Indans; Male; Morphine; Pain; Physostigmine; Piperidines; Rats; Rats, Wistar; Respiratory Insufficiency; Serotonin 5-HT1 Receptor Agonists | 2013 |
Oxygen toxicity is reduced by acetylcholinesterase inhibition in the developing rat brain.
Topics: Animals; Animals, Newborn; Blotting, Western; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Female; Hyperoxia; Immunohistochemistry; Indans; Male; Nerve Degeneration; Oxidative Stress; Oxygen; Physostigmine; Piperidines; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction | 2013 |
Synthesis and biological activity of new donepezil-hydrazinonicotinamide hybrids.
Topics: Alzheimer Disease; Butyrylcholinesterase; Cholinesterase Inhibitors; Colorimetry; Donepezil; Indans; Inhibitory Concentration 50; Niacinamide; Piperidines | 2013 |
Acetylcholinesterase inhibition reveals endogenous nicotinic modulation of glutamate inputs to CA1 stratum radiatum interneurons in hippocampal slices.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Acetylcholine; Age Factors; Animals; Animals, Newborn; CA1 Region, Hippocampal; Cholinesterase Inhibitors; Donepezil; Electric Stimulation; Excitatory Amino Acid Antagonists; Excitatory Postsynaptic Potentials; Glutamic Acid; Guinea Pigs; In Vitro Techniques; Indans; Interneurons; Lethal Dose 50; Male; Mecamylamine; Nicotine; Nicotinic Antagonists; Patch-Clamp Techniques; Piperidines; Rats; Soman | 2013 |
Evolution of a cost-utility model of donepezil for Alzheimer's disease.
Topics: Alzheimer Disease; Costs and Cost Analysis; Decision Support Techniques; Donepezil; Humans; Indans; Models, Economic; Models, Statistical; Nootropic Agents; Piperidines; Uncertainty; United Kingdom | 2013 |
Molecular recognition of rosmarinic acid from Salvia sclareoides extracts by acetylcholinesterase: a new binding site detected by NMR spectroscopy.
Topics: Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cinnamates; Depsides; Donepezil; Glucosides; Indans; Luteolin; Models, Molecular; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Piperidines; Plant Extracts; Portugal; Rosmarinic Acid; Salvia | 2013 |
Pilot study of pharmacological treatment for frontotemporal dementia: risk of donepezil treatment for behavioral and psychological symptoms.
Topics: Apathy; Behavioral Symptoms; Delusions; Donepezil; Follow-Up Studies; Frontotemporal Dementia; Humans; Indans; Irritable Mood; Nootropic Agents; Pilot Projects; Piperidines; Psychomotor Agitation; Risk Assessment | 2013 |
Miniaturized electrochemical system for cholinesterase inhibitor detection.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Donepezil; Electrochemical Techniques; Electrodes; Equipment Design; Erythrocytes; Humans; Indans; Inhibitory Concentration 50; Mice; Mice, Inbred C57BL; Miniaturization; Piperidines | 2013 |
Blood pro-inflammatory cytokines in Alzheimer's disease in relation to the use of acetylcholinesterase inhibitors.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Donepezil; Enzyme-Linked Immunosorbent Assay; Female; Galantamine; Humans; Indans; Interleukin-1beta; Interleukin-6; Male; Phenylcarbamates; Piperidines; Rivastigmine; Sex Factors; Tumor Necrosis Factor-alpha | 2013 |
Restoring long-term potentiation impaired by amyloid-beta oligomers: comparison of an acetylcholinesterase inhibitior and selective neuronal nicotinic receptor agonists.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Amyloid beta-Peptides; Animals; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitors; Donepezil; Hippocampus; Indans; Long-Term Potentiation; Male; Nicotinic Agonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic | 2013 |
A longitudinal study of risk factors for community-based home help services in Alzheimer's disease: the influence of cholinesterase inhibitor therapy.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Chi-Square Distribution; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Home Care Services; Humans; Indans; Linear Models; Longitudinal Studies; Male; Middle Aged; Neuropsychological Tests; Phenylcarbamates; Piperidines; Proportional Hazards Models; Prospective Studies; Risk Factors; Rivastigmine; Treatment Outcome | 2013 |
Memantine is associated with longer survival than donepezil in a Veterans Affairs prescription database, 1997 to 2008.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Databases, Factual; Donepezil; Drug Prescriptions; Excitatory Amino Acid Antagonists; Humans; Indans; Male; Memantine; Middle Aged; Piperidines; Retrospective Studies; Survival Rate; United States; United States Department of Veterans Affairs | 2013 |
Utility of an effect size analysis for communicating treatment effectiveness: a case study of cholinesterase inhibitors for Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Area Under Curve; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Phenylcarbamates; Piperidines; Randomized Controlled Trials as Topic; Rivastigmine; Treatment Outcome | 2013 |
Neuroprotective effects of donepezil against Aβ42-induced neuronal toxicity are mediated through not only enhancing PP2A activity but also regulating GSK-3β and nAChRs activity.
Topics: Amyloid beta-Peptides; Animals; Donepezil; Female; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Indans; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Protein Phosphatase 2; Rats; Rats, Sprague-Dawley; Receptors, Nicotinic | 2013 |
Donepezil-induced response of Spirulina supplemented rat urinary bladder.
Topics: Animals; Cholinesterase Inhibitors; Dietary Supplements; Donepezil; Indans; Male; Piperidines; Rats; Rats, Wistar; Spirulina; Urinary Bladder | 2013 |
[Drugs used for cognitive impairment. Analysis of 1.5 million prescriptions in Argentina].
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Argentina; Child; Child, Preschool; Cholinesterase Inhibitors; Cognition Disorders; Dementia; Dementia, Vascular; Donepezil; Drug Prescriptions; Female; Galantamine; Humans; Indans; Infant; Male; Memantine; Middle Aged; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; Young Adult | 2013 |
Effects of the adenosine A2A antagonist istradefylline on cognitive performance in rats with a 6-OHDA lesion in prefrontal cortex.
Topics: Adenosine A2 Receptor Antagonists; Animals; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Dopamine; Indans; Male; Memory Disorders; Memory, Short-Term; Methamphetamine; Oxidopamine; Piperidines; Prefrontal Cortex; Purines; Rats; Rats, Sprague-Dawley | 2013 |
Psychometric evaluation of ADAS-Cog and NTB for measuring drug response.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychometrics; Randomized Controlled Trials as Topic | 2014 |
Acetylcholinesterase inhibitors: structure based design, synthesis, pharmacophore modeling, and virtual screening.
Topics: Acetylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Drug Design; Drug Evaluation, Preclinical; Humans; Indans; Molecular Docking Simulation; Piperidines; Protein Conformation; Quantitative Structure-Activity Relationship; User-Computer Interface | 2013 |
Effects of sub-chronic donepezil on brain Abeta and cognition in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Memory; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Piperidines; Presenilin-1; Synapses | 2013 |
Steady-state plasma concentration of donepezil enantiomers and its stereoselective metabolism and transport in vitro.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Drug Stability; Female; Humans; Indans; Male; Microsomes, Liver; Piperidines; Stereoisomerism | 2013 |
The anti-inflammatory effect of donepezil on experimental autoimmune encephalomyelitis in C57 BL/6 mice.
Topics: Animals; Anti-Inflammatory Agents; Blood-Brain Barrier; Brain; Cells, Cultured; Donepezil; Dose-Response Relationship, Drug; Encephalomyelitis, Autoimmune, Experimental; Evans Blue; Female; Indans; Interferon-gamma; Interleukin-4; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Mice; Mice, Inbred C57BL; Nerve Growth Factor; Phosphorylation; Piperidines; Protein Precursors; Proto-Oncogene Proteins c-akt | 2013 |
Donepezil markedly improves long-term survival in rats with chronic heart failure after extensive myocardial infarction.
Topics: Animals; Cholinesterase Inhibitors; Chronic Disease; Donepezil; Heart Failure; Indans; Male; Myocardial Infarction; Piperidines; Rats; Rats, Sprague-Dawley; Time Factors | 2013 |
Interaction study of acetylcholinestrase inhibitors on pharmacokinetics of memantine in rat plasma by HPLC-fluorescence method.
Topics: Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Drug Interactions; Galantamine; Indans; Male; Memantine; Piperidines; Rats; Rats, Wistar; Spectrometry, Fluorescence | 2013 |
Attenuating Aβ1-42-induced toxicity by a novel acetylcholinesterase inhibitor.
Topics: Acetylcholinesterase; Amyloid beta-Peptides; Animals; Anthracenes; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Glutathione; Immunohistochemistry; Indans; Male; Maze Learning; Memory; Memory Disorders; Mice; Microscopy, Electron, Scanning; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Muscarinic Antagonists; Oxidation-Reduction; Peptide Fragments; Piperidines; Psychomotor Performance; Pyrazoles; Scopolamine; Tissue Fixation | 2013 |
Efficacy of increasing donepezil in mild to moderate Alzheimer's disease patients who show a diminished response to 5 mg donepezil: a preliminary study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Caregivers; Cholinesterase Inhibitors; Cognition; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indans; Japan; Male; Middle Aged; Piperidines; Severity of Illness Index; Surveys and Questionnaires; Treatment Outcome | 2013 |
The response of the autonomic nervous system to the cholinesterase inhibitor, donepezil.
Topics: Animals; Autonomic Nervous System; Cholinesterase Inhibitors; Donepezil; Heart Rate; Indans; Male; Piperidines; Rats; Rats, Wistar | 2013 |
In vitro and in vivo correlation of disintegration and bitter taste masking using orally disintegrating tablet containing ion exchange resin-drug complex.
Topics: Administration, Oral; Adult; Donepezil; Female; Humans; Indans; Ion Exchange Resins; Male; Piperidines; Resins, Synthetic; Solubility; Tablets; Taste; Tongue; Young Adult | 2013 |
Serum adipokine levels modified by donepezil treatment in Alzheimer's disease.
Topics: Adipokines; Adiponectin; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Male; Neuropsychological Tests; Piperidines; Prospective Studies; Time Factors | 2014 |
[Donepezil as treatment of Charles Bonnet syndrome].
Topics: Acetylcholine; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Hallucinations; Humans; Indans; Piperidines; Thalamus | 2013 |
Cholinesterase inhibitor, donepezil, improves visual contrast detectability in freely behaving rats.
Topics: Animals; Choice Behavior; Cholinesterase Inhibitors; Contrast Sensitivity; Donepezil; Indans; Male; Photic Stimulation; Piperidines; Rats; Rats, Long-Evans | 2013 |
Donepezil-induced confusional state in a patient with autopsy-proven behavioral-variant frontotemporal dementia.
Topics: Adult; Behavioral Symptoms; Cholinesterase Inhibitors; Confusion; Donepezil; Frontotemporal Dementia; Humans; Indans; Male; Piperidines | 2013 |
Cholinergic interactions between donepezil and prucalopride in human colon: potential to treat severe intestinal dysmotility.
Topics: Adult; Aged; Aged, 80 and over; Benzofurans; Cholinesterase Inhibitors; Colon; Donepezil; Drug Synergism; Female; Gastrointestinal Motility; Humans; In Vitro Techniques; Indans; Male; Middle Aged; Muscle Contraction; Piperidines; Serotonin 5-HT4 Receptor Agonists | 2013 |
RP-HPLC analytical method development and optimization for quantification of donepezil hydrochloride in orally disintegrating tablet.
Topics: Acetonitriles; Administration, Oral; Buffers; Calibration; Chemistry, Pharmaceutical; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Donepezil; Drug Stability; Hydrogen-Ion Concentration; Indans; Limit of Detection; Methanol; Phosphoric Acids; Piperidines; Reference Standards; Reproducibility of Results; Solubility; Solvents; Tablets; Technology, Pharmaceutical; Time Factors | 2013 |
Acetylcholine elevation relieves cognitive rigidity and social deficiency in a mouse model of autism.
Topics: Acetylcholine; Animals; Autistic Disorder; Caudate Nucleus; Cholinesterase Inhibitors; Cognition Disorders; Corpus Striatum; Disease Models, Animal; Donepezil; Drug Administration Routes; Exploratory Behavior; Indans; Interpersonal Relations; Locomotion; Male; Maze Learning; Mice; Mice, Inbred Strains; Piperidines; Social Behavior Disorders; Stereotyped Behavior | 2014 |
Structural analysis of 2-arylidene-1-indanone derivatives by electrospray ionization tandem mass spectrometry.
Topics: Cholinesterase Inhibitors; Donepezil; Indans; Piperidines; Spectrometry, Mass, Electrospray Ionization | 2013 |
Modulation of electroosmosis and flux through skin: effect of propylene glycol.
Topics: Acetaminophen; Animals; Diffusion; Donepezil; Dose-Response Relationship, Drug; Electroosmosis; In Vitro Techniques; Indans; Mice; Piperidines; Propylene Glycol; Skin Absorption; Solubility; Viscosity | 2014 |
Impact of CYP2D6 and CYP3A4 genetic polymorphism on combined cholinesterase inhibitors and memantine treatment in mild to moderate Alzheimer's disease.
Topics: Aged; Alleles; Alzheimer Disease; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cognitive Dysfunction; Cytochrome P-450 CYP2D6; Cytochrome P-450 CYP3A; Diagnostic and Statistical Manual of Mental Disorders; DNA; Donepezil; Dopamine Agents; Drug Therapy, Combination; Female; Genotype; Humans; Indans; India; Male; Memantine; Middle Aged; Neuropsychological Tests; Nootropic Agents; Piperidines; Polymorphism, Genetic; Tandem Mass Spectrometry; Treatment Outcome | 2014 |
Effect of olanzapine on scopolamine induced deficits in differential reinforcement of low rate 72s (DRL-72s) schedule in rats: involvement of the serotonergic receptors in restoring the deficits.
Topics: Animals; Antipsychotic Agents; Behavior, Animal; Benzodiazepines; Cholinesterase Inhibitors; Conditioning, Operant; Donepezil; Haloperidol; Impulsive Behavior; Indans; Male; Muscarinic Antagonists; Olanzapine; Piperidines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Reinforcement, Psychology; Scopolamine; Serotonin Antagonists; Sulfones | 2013 |
Sex and ESR1 genotype may influence the response to treatment with donepezil and rivastigmine in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Brief Psychiatric Rating Scale; Cholinesterase Inhibitors; Donepezil; Estrogen Receptor alpha; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; Humans; Indans; Male; Middle Aged; Phenylcarbamates; Piperidines; Polymorphism, Single Nucleotide; Rivastigmine; Sex Factors | 2014 |
Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Azoles; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Electrophorus; Glutathione Peroxidase; Humans; Indans; Isoindoles; Kinetics; Ligands; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Organoselenium Compounds; Peptide Fragments; Peroxynitrous Acid; Piperidines; Protein Multimerization; Protein Structure, Secondary; Thioredoxin-Disulfide Reductase; Toxicity Tests, Acute | 2013 |
Donepezil inhibits the amyloid-beta oligomer-induced microglial activation in vitro and in vivo.
Topics: Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents; Cells, Cultured; Donepezil; Hippocampus; Indans; Inflammation Mediators; Male; Memory Disorders; Mice; Mice, Inbred ICR; Microglia; p38 Mitogen-Activated Protein Kinases; Piperidines; Rats, Sprague-Dawley; Transcription Factor RelA | 2014 |
Free radical scavenging effect of donepezil as the possible contribution to its memory enhancing activity in mice.
Topics: Animals; Antioxidants; Biomarkers; Donepezil; Free Radical Scavengers; Free Radicals; Glutathione; Indans; Lipopolysaccharides; Male; Malondialdehyde; Memory; Memory Disorders; Mice; Oxidative Stress; Piperidines; Scopolamine | 2014 |
An over expression APP model for anti-Alzheimer disease drug screening created by zinc finger nuclease technology.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anti-Inflammatory Agents, Non-Steroidal; Apoptosis; BALB 3T3 Cells; Base Sequence; Cholinesterase Inhibitors; Deoxyribonucleases; DNA Cleavage; Donepezil; Drug Evaluation, Preclinical; Galantamine; Gene Expression; Genetic Engineering; Green Fluorescent Proteins; Homologous Recombination; Humans; Ibuprofen; Indans; Mice; Molecular Sequence Data; Peptide Fragments; Piperidines; Recombinant Proteins; Zinc Fingers | 2013 |
Network dynamics predict improvement in working memory performance following donepezil administration in healthy young adults.
Topics: Adult; Brain Mapping; Brain Waves; Cholinesterase Inhibitors; Donepezil; Evoked Potentials; Female; Humans; Indans; Male; Memory, Short-Term; Mental Recall; Pattern Recognition, Visual; Performance-Enhancing Substances; Piperidines; Young Adult | 2014 |
Protective effect of donepezil hydrochloride on cerebral ischemia/reperfusion injury in mice.
Topics: Animals; Brain Ischemia; Donepezil; Hippocampus; Humans; Indans; Malondialdehyde; Memory; Mice; Neurons; Piperidines; Reperfusion Injury; Superoxide Dismutase | 2014 |
Increased levels of plasma p3-alcα35, a major fragment of Alcadeinα by γ-secretase cleavage, in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amyloid Precursor Protein Secretases; Biomarkers; Calcium-Binding Proteins; Cognition Disorders; Cohort Studies; Disease Progression; Donepezil; Endophenotypes; Female; Humans; Indans; Male; Nootropic Agents; Peptide Fragments; Piperidines | 2014 |
QSAR, docking, dynamic simulation and quantum mechanics studies to explore the recognition properties of cholinesterase binding sites.
Topics: Binding Sites; Butyrylcholinesterase; Cholinesterases; Donepezil; Drug Delivery Systems; Galantamine; Indans; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Piperidines; Quantitative Structure-Activity Relationship | 2014 |
Donepezil 23 mg: a brief insight on efficacy and safety concerns.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Piperidines; Treatment Outcome | 2013 |
[A case report of early-onset Alzheimer's disease with multiple psychotic symptoms, finally diagnosed as APPV717I mutation by genetic testing].
Topics: Alzheimer Disease; Brain; Donepezil; Genetic Testing; Humans; Indans; Male; Middle Aged; Mutation; Piperidines | 2013 |
A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system.
Topics: Animals; Apoptosis; Central Nervous System; Cerebral Cortex; Donepezil; Drug Tolerance; Humans; Indans; Morphine; Neuroprotective Agents; Nociception; Pain Measurement; Piperidines; Rats; Spinal Cord | 2014 |
A brief report on the efficacy of donepezil in pain management in Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Pain; Piperidines | 2014 |
Donepezil enhances Purkinje cell survival and alleviates motor dysfunction by inhibiting cholesterol synthesis in a murine model of Niemann Pick disease type C.
Topics: Adult Stem Cells; Animals; ATP-Binding Cassette Transporters; Cell Survival; Cells, Cultured; Cerebellum; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Gene Expression Regulation; Humans; Indans; Intracellular Signaling Peptides and Proteins; Lateral Ventricles; Liver X Receptors; Mice; Mice, Inbred BALB C; Mice, Transgenic; Movement Disorders; Mutation; Niemann-Pick C1 Protein; Niemann-Pick Disease, Type C; Orphan Nuclear Receptors; Piperidines; Proteins; Psychomotor Performance; Purkinje Cells; Sterol Regulatory Element Binding Protein 1; Sterol Regulatory Element Binding Protein 2 | 2014 |
Donepezil-associated sick sinus syndrome.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Piperidines; Sick Sinus Syndrome | 2014 |
Design, synthesis, pharmacological evaluation, QSAR analysis, molecular modeling and ADMET of novel donepezil-indolyl hybrids as multipotent cholinesterase/monoamine oxidase inhibitors for the potential treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Electrophorus; Horses; Humans; Indans; Indoles; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Quantitative Structure-Activity Relationship | 2014 |
Cilostazol add-on therapy in patients with mild dementia receiving donepezil: a retrospective study.
Topics: Aged; Cholinesterase Inhibitors; Cilostazol; Dementia; Donepezil; Drug Therapy, Combination; Female; Follow-Up Studies; Humans; Indans; Male; Neuroprotective Agents; Neuropsychological Tests; Piperidines; Prognosis; Retrospective Studies; Tetrazoles | 2014 |
Cholinergic symptoms with low serum cholinesterase from therapeutic cholinesterase inhibitor toxicity.
Topics: Aged; Bradycardia; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Humans; Indans; Lewy Body Disease; Male; Miosis; Parkinson Disease; Phenylcarbamates; Piperidines; Rivastigmine | 2014 |
Donepezil-induced mania.
Topics: Aged; Bipolar Disorder; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Humans; Indans; Male; Nootropic Agents; Piperidines | 2014 |
Antidementia drug use among community-dwelling individuals with Alzheimer's disease in Finland: a nationwide register-based study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Diagnostic and Statistical Manual of Mental Disorders; Donepezil; Drug Monitoring; Drug Prescriptions; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Female; Finland; Follow-Up Studies; Galantamine; Guideline Adherence; Humans; Indans; Male; Memantine; Nootropic Agents; Phenylcarbamates; Piperidines; Practice Guidelines as Topic; Proportional Hazards Models; Registries; Rivastigmine | 2014 |
Cardiovascular pharmacodynamics of donepezil hydrochloride on the PR and QT intervals in patients with dementia.
Topics: Aged; Cognition Disorders; Dementia; Donepezil; Electrocardiography; Female; Heart; Humans; Indans; Male; Nootropic Agents; Piperidines | 2014 |
Effect of dehydroepiandrosterone (DHEA) on memory and brain derived neurotrophic factor (BDNF) in a rat model of vascular dementia.
Topics: Acetylcholine; Animals; Brain-Derived Neurotrophic Factor; Carotid Artery, Common; Dehydroepiandrosterone; Dementia, Vascular; Donepezil; Dopamine; Hippocampus; Indans; Male; Memory; Neuroprotective Agents; Neuropsychological Tests; Norepinephrine; Piperidines; Rats; Rats, Sprague-Dawley | 2014 |
[Donepezil therapy by neuropathic pain].
Topics: Aged; Analgesics; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Neuralgia; Piperidines; Shoulder Pain; Treatment Outcome | 2013 |
Dose-dependent sigma-1 receptor occupancy by donepezil in rat brain can be assessed with (11)C-SA4503 and microPET.
Topics: Animals; Brain; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Piperazines; Piperidines; Radionuclide Imaging; Rats; Rats, Wistar; Receptors, sigma; Sigma-1 Receptor | 2014 |
Kinetic and structural analysis of the irreversible inhibition of human monoamine oxidases by ASS234, a multi-target compound designed for use in Alzheimer's disease.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Clorgyline; Donepezil; Flavin-Adenine Dinucleotide; Humans; Indans; Indoles; Kinetics; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neuroprotective Agents; Piperidines; Recombinant Proteins; Saccharomyces cerevisiae | 2014 |
Effects of donepezil dose escalation in Parkinson's patients with dementia receiving long-term donepezil treatment: an exploratory study.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indans; Long-Term Care; Male; Middle Aged; Parkinson Disease; Piperidines; Prospective Studies; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2014 |
Exploiting the buccal mucosa as an alternative route for the delivery of donepezil hydrochloride.
Topics: Animals; Calorimetry; Donepezil; Indans; Mouth Mucosa; Nootropic Agents; Piperidines; Swine | 2014 |
Sodium-glucose transporter type 3-mediated neuroprotective effect of acetylcholine suppresses the development of cerebral ischemic neuronal damage.
Topics: Acetylcholine; Animals; Animals, Outbred Strains; Astrocytes; Blood Glucose; Brain Ischemia; Cholinesterase Inhibitors; Corpus Striatum; Disease Models, Animal; Donepezil; Gene Knockdown Techniques; Hippocampus; Hypothalamus; Indans; Infarction, Middle Cerebral Artery; Male; Mice; Neurons; Piperidines; RNA, Small Interfering; Sodium-Glucose Transport Proteins; Sodium-Glucose Transporter 1; Stress, Physiological | 2014 |
Donepezil nanosuspension intended for nose to brain targeting: In vitro and in vivo safety evaluation.
Topics: Administration, Intranasal; Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Donepezil; Drug Delivery Systems; In Vitro Techniques; Indans; Nanostructures; Piperidines; Rats; Rats, Sprague-Dawley; Suspensions | 2014 |
A novel PSEN1 mutation in a patient with sporadic early-onset Alzheimer's disease and prominent cerebellar ataxia.
Topics: Adult; Alzheimer Disease; Cerebellar Ataxia; Cholinesterase Inhibitors; DNA Mutational Analysis; Donepezil; Female; Fluorodeoxyglucose F18; Humans; Indans; Magnetic Resonance Imaging; Male; Mutation; Piperidines; Positron-Emission Tomography; Presenilin-1; Young Adult | 2014 |
Donepezil and life expectancy in Alzheimer's disease: a retrospective analysis in the Tajiri Project.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Japan; Life Expectancy; Male; Nursing Homes; Piperidines; Retrospective Studies | 2014 |
The potentially protective effect of donepezil in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Atrophy; Case-Control Studies; Donepezil; Female; Hippocampus; Humans; Indans; Magnetic Resonance Imaging; Male; Mental Status Schedule; Middle Aged; Nootropic Agents; Organ Size; Piperidines; Regression Analysis; Treatment Outcome | 2014 |
Prolonged altered mental status and bradycardia following pediatric donepezil ingestion.
Topics: Accidents, Home; Bradycardia; Cholinesterase Inhibitors; Donepezil; Emergency Service, Hospital; Humans; Indans; Infant; Male; Nootropic Agents; Piperidines; Psychoses, Substance-Induced; Severity of Illness Index; Sleep Stages; Vomiting | 2014 |
Influence of cholinesterase inhibitors, donepezil and rivastigmine on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference in rats.
Topics: Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Donepezil; Drug-Seeking Behavior; Indans; Male; Mecamylamine; Morphine; Motor Activity; Muscarinic Antagonists; Narcotics; Nicotinic Antagonists; Phenylcarbamates; Piperidines; Rats, Wistar; Rivastigmine; Scopolamine; Space Perception | 2014 |
Expression of recombinant human acetylcholinesterase and its application in screening its inhibitors.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; HEK293 Cells; Humans; Indans; Inhibitory Concentration 50; Kinetics; Piperidines; Plasmids; Recombinant Proteins; Transfection | 2014 |
Donepezil + propargylamine + 8-hydroxyquinoline hybrids as new multifunctional metal-chelators, ChE and MAO inhibitors for the potential treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Hep G2 Cells; Humans; Hydroxyquinolines; Indans; Male; Memory; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Pargyline; Piperidines; Propylamines; Rats | 2014 |
Generating genius: how an Alzheimer's drug became considered a 'cognitive enhancer' for healthy individuals.
Topics: Adult; Aerospace Medicine; Aged; Alzheimer Disease; Aviation; Cholinesterase Inhibitors; Computer Simulation; Donepezil; Female; Humans; Indans; Male; Middle Aged; Nootropic Agents; Patient Safety; Piperidines; Psychomotor Performance; Reaction Time; Research Design; User-Computer Interface | 2014 |
Quantifying ligand-receptor interactions for gorge-spanning acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; GPI-Linked Proteins; Indans; Ligands; Molecular Conformation; Molecular Docking Simulation; Molecular Structure; Piperidines; Protein Binding; Protein Structure, Tertiary; Quantitative Structure-Activity Relationship; Reproducibility of Results; Thermodynamics | 2015 |
Donepezil reverses nicotine withdrawal-induced deficits in contextual fear conditioning in C57BL/6J mice.
Topics: Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Donepezil; Electroshock; Fear; Freezing Reaction, Cataleptic; Indans; Locomotion; Male; Mice, Inbred C57BL; Nicotine; Nicotinic Agonists; Nootropic Agents; Piperidines; Substance Withdrawal Syndrome | 2014 |
Synthesis and evaluation of anti-acetylcholinesterase activity of some benzothiazole based new piperazine-dithiocarbamate derivatives.
Topics: Benzothiazoles; Cholinesterase Inhibitors; Donepezil; Indans; Piperazines; Piperidines; Structure-Activity Relationship; Thiocarbamates | 2015 |
7-MEOTA-donepezil like compounds as cholinesterase inhibitors: Synthesis, pharmacological evaluation, molecular modeling and QSAR studies.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Quantitative Structure-Activity Relationship; Recombinant Proteins; Tacrine | 2014 |
Frontoparietal cognitive control of verbal memory recall in Alzheimer's disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Executive Function; Female; Frontal Lobe; Functional Neuroimaging; Humans; Indans; Magnetic Resonance Imaging; Male; Mental Recall; Middle Aged; Parietal Lobe; Piperidines; Speech Perception; Young Adult | 2014 |
The involvement of sigma1 receptors in donepezil-induced rescue of hippocampal LTP impaired by beta-amyloid peptide.
Topics: Amyloid beta-Peptides; Animals; CA1 Region, Hippocampal; Cholinesterase Inhibitors; Donepezil; Haloperidol; Indans; Long-Term Potentiation; Male; Morpholines; Peptide Fragments; Piperidines; Rats; Rats, Wistar; Receptors, sigma | 2014 |
Reversal by aqueous extracts of Cistanche tubulosa from behavioral deficits in Alzheimer's disease-like rat model: relevance for amyloid deposition and central neurotransmitter function.
Topics: Alzheimer Disease; Amyloid; Animals; Brain; Brain Chemistry; Cistanche; Disease Models, Animal; Donepezil; Exploratory Behavior; Indans; Male; Maze Learning; Neurotransmitter Agents; Piperidines; Plant Extracts; Rats; Rats, Sprague-Dawley | 2014 |
Motor cortex excitability changes in mild Alzheimer's disease are reversed by donepezil.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Motor Cortex; Piperidines; Severity of Illness Index; Transcranial Magnetic Stimulation; Treatment Outcome | 2014 |
Stereotypy after cerebellar infarction.
Topics: Aged; Brain Infarction; Cerebellar Diseases; Cholinesterase Inhibitors; Cilostazol; Donepezil; Female; Fluorodeoxyglucose F18; Humans; Indans; Magnetic Resonance Angiography; Neurologic Examination; Neuroprotective Agents; Piperidines; Stereotyped Behavior; Tetrazoles; Tomography, Emission-Computed, Single-Photon | 2014 |
Hippocampal P3-like auditory event-related potentials are disrupted in a rat model of cholinergic degeneration in Alzheimer's disease: reversal by donepezil treatment.
Topics: Alzheimer Disease; Animals; Antibodies, Monoclonal; Auditory Perception; CA1 Region, Hippocampal; Choline O-Acetyltransferase; Cholinergic Neurons; Disease Models, Animal; Donepezil; Electrodes, Implanted; Evoked Potentials, Auditory; Indans; Male; Nerve Degeneration; Neuroprotective Agents; Neuropsychological Tests; Piperidines; Psychomotor Performance; Rats, Sprague-Dawley; Ribosome Inactivating Proteins, Type 1; Saporins | 2014 |
Novel multipotent AChEI-CCB attenuates hyperhomocysteinemia-induced memory deficits and Neuropathologies in rats.
Topics: Animals; Brain Diseases; Calcium Channel Blockers; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Hippocampus; Homocysteine; Hyperhomocysteinemia; Indans; Male; Maze Learning; Memory Disorders; Nerve Tissue Proteins; Nifedipine; Piperidines; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Silver Staining; Tacrine | 2014 |
Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia.
Topics: Acetylcholinesterase; alpha7 Nicotinic Acetylcholine Receptor; Animals; Antipsychotic Agents; Aza Compounds; Cholinesterase Inhibitors; Cognition Disorders; Dioxins; Disease Models, Animal; Dizocilpine Maleate; Donepezil; Indans; Male; Mice, Inbred C57BL; Nicotinic Agonists; Nootropic Agents; Piperidines; Risperidone; Schizophrenia; Schizophrenic Psychology; Spatial Memory | 2014 |
Anti-dementia drugs in a psychiatric hospital for dementia patients.
Topics: Aged; Dementia; Donepezil; Galantamine; Hospitalization; Hospitals, Psychiatric; Humans; Indans; Nootropic Agents; Phenylcarbamates; Piperidines; Rivastigmine | 2014 |
Donepezil can improve ischemic muscle atrophy by activating angiomyogenic properties of satellite cells.
Topics: Animals; Cells, Cultured; Donepezil; Fibroblast Growth Factor 2; Hindlimb; Humans; Indans; Interleukin-1beta; Ischemia; Male; Mice; Muscle Development; Muscular Atrophy; Neovascularization, Physiologic; Nootropic Agents; Piperidines; Satellite Cells, Skeletal Muscle; Up-Regulation; Vascular Endothelial Growth Factor A | 2014 |
The IDO inhibitor coptisine ameliorates cognitive impairment in a mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Berberine; Brain; Cell Survival; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Enzyme Inhibitors; Humans; Indans; Indoleamine-Pyrrole 2,3,-Dioxygenase; Male; Mice, Transgenic; Nootropic Agents; PC12 Cells; Piperidines; Plaque, Amyloid; Presenilin-1; Rats | 2015 |
Nicotinic and muscarinic agonists and acetylcholinesterase inhibitors stimulate a common pathway to enhance GluN2B-NMDAR responses.
Topics: Animals; CA1 Region, Hippocampal; Cholinesterase Inhibitors; Donepezil; Excitatory Postsynaptic Potentials; Indans; Long-Term Potentiation; Muscarinic Agonists; Nicotine; Nicotinic Agonists; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M1; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Succinimides | 2014 |
Subchronic treatment of donepezil rescues impaired social, hyperactive, and stereotypic behavior in valproic acid-induced animal model of autism.
Topics: Acetylcholinesterase; Animals; Autistic Disorder; Behavior, Animal; Blotting, Western; Cells, Cultured; Chromatin Immunoprecipitation; Disease Models, Animal; Donepezil; Female; Histones; Immunohistochemistry; Indans; Mice, Inbred ICR; Piperidines; Pregnancy; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; Stereotyped Behavior; Valproic Acid | 2014 |
Effect of backing films on the transdermal delivery of donepezil from patches.
Topics: Administration, Cutaneous; Animals; Calorimetry, Differential Scanning; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Excipients; Indans; Kinetics; Permeability; Pilot Projects; Piperidines; Rabbits; Skin; Skin Absorption; Solubility; Spectroscopy, Fourier Transform Infrared; Technology, Pharmaceutical; Transdermal Patch; Water | 2014 |
Evaluation of potential antiamnesic activities of aqueous extract of Vitex trifolia leaves against scopolamine induced amnesia and in normal rats.
Topics: Administration, Oral; Amnesia; Animals; Cognition; Donepezil; Dose-Response Relationship, Drug; Indans; Maze Learning; Piperidines; Plant Extracts; Plant Leaves; Rats; Rats, Wistar; Scopolamine; Vitex | 2015 |
Effect of deprotenizing agent and quantification of donepezil hydrochloride in human plasma.
Topics: Blood Proteins; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Piperidines | 2014 |
Cortical EEG oscillations and network connectivity as efficacy indices for assessing drugs with cognition enhancing potential.
Topics: Animals; Cerebral Cortex; Cognition; Donepezil; Drug Evaluation, Preclinical; Electrodes, Implanted; Electroencephalography; Galantamine; Gamma Rhythm; Indans; Male; Memantine; Motor Activity; Muscarinic Antagonists; Neural Pathways; Nootropic Agents; Phenylcarbamates; Piperidines; Principal Component Analysis; Rats, Sprague-Dawley; Rivastigmine; Scopolamine; Signal Processing, Computer-Assisted; Tacrine; Theta Rhythm | 2014 |
Encephalopathy from unintentional donepezil and memantine ingestion.
Topics: Brain Diseases; Child, Preschool; Donepezil; Electroencephalography; Female; Hallucinations; Humans; Indans; Memantine; Piperidines | 2014 |
Adding the acetylcholinesterase inhibitor, donepezil, to losartan treatment markedly improves long-term survival in rats with chronic heart failure.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Cholinesterase Inhibitors; Chronic Disease; Disease Models, Animal; Disease Progression; Donepezil; Drug Synergism; Drug Therapy, Combination; Heart Failure; Indans; Losartan; Myocardial Infarction; Piperidines; Rats; Rats, Sprague-Dawley; Treatment Outcome; Vagus Nerve | 2014 |
Donepezil-induced myoclonus in a patient with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Myoclonus; Piperidines | 2014 |
Donepezil-associated mania in two patients who were using donepezil without a prescription.
Topics: Adult; Bipolar Disorder; Donepezil; Humans; Indans; Male; Middle Aged; Nootropic Agents; Piperidines | 2014 |
Cognitive enhancing effect of the fermented Gumiganghwal-tang on scopolamine-induced memory impairment in mice.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Behavior, Animal; Cholinergic Antagonists; Cholinesterase Inhibitors; Dietary Supplements; Disease Models, Animal; Donepezil; Fermentation; GPI-Linked Proteins; Hippocampus; Indans; Male; Maze Learning; Memory Disorders; Mice, Inbred ICR; Muscarinic Antagonists; Nerve Tissue Proteins; Neurons; Nootropic Agents; Piperidines; Plant Extracts; Republic of Korea; Scopolamine | 2016 |
Measures to prevent Alzheimer's patients from discontinuing the use of cholinesterase inhibitors.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Medication Adherence; Piperidines; Time Factors | 2014 |
Distribution of intravenously administered acetylcholinesterase inhibitor and acetylcholinesterase activity in the adrenal gland: 11C-donepezil PET study in the normal rat.
Topics: Acetylcholinesterase; Administration, Intravenous; Adrenal Glands; Animals; Carbon Radioisotopes; Cholinesterase Inhibitors; Donepezil; Indans; Male; Piperidines; Positron-Emission Tomography; Rats; Time Factors; Tissue Distribution | 2014 |
Effects of donepezil, an acetylcholinesterase inhibitor, on neurogenesis in a rat model of vascular dementia.
Topics: Animals; Cholinesterase Inhibitors; Cognition; Dementia, Vascular; Dentate Gyrus; Disease Models, Animal; Donepezil; Indans; Male; Maze Learning; Memory; Neurogenesis; Piperidines; Rats; Rats, Wistar | 2014 |
Morphology-based mammalian stem cell tests reveal potential developmental toxicity of donepezil.
Topics: Animals; Cell Line, Tumor; Cell Shape; Donepezil; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryoid Bodies; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genes, Regulator; Humans; In Vitro Techniques; Indans; Mice; Morphogenesis; Piperidines; Reverse Transcriptase Polymerase Chain Reaction; Somites | 2014 |
Biopolymer-based transdermal films of donepezil as an alternative delivery approach in Alzheimer's disease treatment.
Topics: Adhesiveness; Administration, Cutaneous; Alzheimer Disease; Animals; Biopolymers; Chemistry, Pharmaceutical; Cyclohexenes; Donepezil; Dosage Forms; Indans; Limonene; Lipids; Permeability; Piperidines; Plasticizers; Propylene Glycol; Skin; Skin Absorption; Swine; Terpenes | 2015 |
Brain toxicity and inflammation induced in vivo in mice by the amyloid-β forty-two inducer aftin-4, a roscovitine derivative.
Topics: Adenine; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Anti-Inflammatory Agents, Non-Steroidal; Butyrates; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Encephalitis; Enzyme Inhibitors; Hippocampus; Hydrocarbons, Halogenated; Ibuprofen; Indans; Learning Disabilities; Male; Memory Disorders; Mice; Neuroprotective Agents; Oxidative Stress; Peptide Fragments; Piperidines | 2015 |
Novel ionically crosslinked acrylamide-grafted poly(vinyl alcohol)/sodium alginate/sodium carboxymethyl cellulose pH-sensitive microspheres for delivery of Alzheimer's drug donepezil hydrochloride: Preparation and optimization of release conditions.
Topics: Acrylamide; Alginates; Alzheimer Disease; Carboxymethylcellulose Sodium; Chlorides; Donepezil; Drug Carriers; Drug Compounding; Drug Liberation; Ferric Compounds; Glucuronic Acid; Hexuronic Acids; Hydrogen-Ion Concentration; Indans; Kinetics; Microspheres; Piperidines; Polyvinyl Alcohol | 2016 |
In vivo imaging of human acetylcholinesterase density in peripheral organs using 11C-donepezil: dosimetry, biodistribution, and kinetic analyses.
Topics: Acetylcholinesterase; Aged; Animals; Autoradiography; Carbon Radioisotopes; Diagnostic Imaging; Donepezil; Female; Healthy Volunteers; Humans; Indans; Kinetics; Ligands; Male; Middle Aged; Parasympathetic Nervous System; Piperidines; Positron-Emission Tomography; Radiometry; Swine; Time Factors; Tissue Distribution; Whole Body Imaging | 2014 |
Donepezil-induced hepatotoxicity in an elderly adult taking fluoxetine.
Topics: Aged; Alanine Transaminase; Alzheimer Disease; Antidepressive Agents, Second-Generation; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Cholinesterase Inhibitors; Donepezil; Fluoxetine; Humans; Indans; Male; Piperidines | 2014 |
Formulation and evaluation of transdermal patches of donepezil.
Topics: Administration, Cutaneous; Animals; Chemistry, Pharmaceutical; Donepezil; Drug Evaluation, Preclinical; Indans; Piperidines; Rats; Skin Absorption; Transdermal Patch | 2015 |
FOXO1 locus and acetylcholinesterase inhibitors in elderly patients with Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Female; Forkhead Box Protein O1; Forkhead Transcription Factors; Galantamine; Gene Frequency; Genetic Loci; Genotype; Haplotypes; Humans; Indans; Male; Oxidative Stress; Phenylcarbamates; Piperidines; Prospective Studies; Rivastigmine | 2014 |
Effects of thyroxine and donepezil on hippocampal acetylcholine content, acetylcholinesterase activity, synaptotagmin-1 and SNAP-25 expression in hypothyroid adult rats.
Topics: Acetylcholine; Acetylcholinesterase; Animals; Antithyroid Agents; Cholinesterase Inhibitors; Donepezil; Hippocampus; Hypothyroidism; Immunohistochemistry; Indans; Luminescent Measurements; Male; Piperidines; Propylthiouracil; Rats; Rats, Sprague-Dawley; Synaptosomal-Associated Protein 25; Synaptotagmin I; Thyrotropin; Thyroxine; Triiodothyronine | 2015 |
Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Drug Design; Humans; Indans; Models, Molecular; Molecular Structure; Monoamine Oxidase Inhibitors; Piperidines; Pyridines; Quantitative Structure-Activity Relationship; Recombinant Proteins | 2014 |
Clinical compliance of donepezil in treating Alzheimer's disease in taiwan.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Medication Adherence; Piperidines; Taiwan | 2015 |
Therapeutic drug monitoring for patients with Alzheimer dementia to improve treatment with donepezil.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Monitoring; Female; Humans; Indans; Male; Piperidines; Retrospective Studies; Treatment Outcome | 2015 |
Ameliorative effect of rosmarinic acid on scopolamine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Cholinergic Antagonists; Cinnamates; Depsides; Donepezil; Indans; Male; Memory; Memory Disorders; Neuroprotective Agents; Piperidines; Rats, Wistar; Reaction Time; Rosmarinic Acid; Scopolamine | 2015 |
Protective effect of n-butanol extract from Alpinia oxyphylla on learning and memory impairments.
Topics: 1-Butanol; Alpinia; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Avoidance Learning; Cerebral Cortex; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Glutathione; Indans; Learning Disabilities; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred ICR; Neuroprotective Agents; Nootropic Agents; Peptide Fragments; Phytotherapy; Piperidines; Plant Extracts; Thiazolidinediones | 2015 |
Procognitive effect of AC-3933 in aged mice, and synergistic effect of combination with donepezil in scopolamine-treated mice.
Topics: Aging; Animals; Donepezil; Drug Synergism; Flumazenil; GABA-A Receptor Agonists; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Inbred C57BL; Naphthyridines; Nootropic Agents; Oxadiazoles; Piperidines; Rats; Scopolamine | 2014 |
The protective effects of Donepezil (DP) against cartilage matrix destruction induced by TNF-α.
Topics: Cartilage, Articular; Cholinesterase Inhibitors; Chondrocytes; Collagen Type II; Donepezil; Enzyme Induction; Humans; Indans; Interferon Regulatory Factor-1; Matrix Metalloproteinase 13; Osteoarthritis; Piperidines; Proteolysis; RNA, Messenger; STAT1 Transcription Factor; Tumor Necrosis Factor-alpha | 2014 |
Physiological and neurobehavioral effects of cholinesterase inhibition in healthy adults.
Topics: Acetylcholinesterase; Adolescent; Adult; Alkaloids; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterases; Donepezil; Female; Galantamine; Humans; Indans; Male; Memory; Piperidines; Reaction Time; Sesquiterpenes; Young Adult | 2015 |
Improved cognition without adverse effects: novel M1 muscarinic potentiator compares favorably to donepezil and xanomeline in rhesus monkey.
Topics: Aged; Alzheimer Disease; Animals; Appetitive Behavior; Attention; Cognition; Defecation; Donepezil; Female; Humans; Indans; Macaca mulatta; Male; Muscarinic Agonists; Neuropsychological Tests; Orientation; Piperidines; Problem Solving; Pyridines; Quinolizines; Receptor, Muscarinic M1; Salivation; Thiadiazoles | 2015 |
Effects of donepezil on hERG potassium channels.
Topics: Blotting, Western; Cell Membrane; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Fluoxetine; HEK293 Cells; Humans; Indans; Kinetics; Membrane Potentials; Patch-Clamp Techniques; Piperidines; Selective Serotonin Reuptake Inhibitors | 2015 |
Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.
Topics: Alzheimer Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; Donepezil; Drug Interactions; Humans; Indans; Microsomes, Liver; Models, Molecular; Molecular Structure; Nootropic Agents; Piperidines; Structure-Activity Relationship | 2015 |
R-(+) and S-(-) isomers of cotinine augment cholinergic responses in vitro and in vivo.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Behavior, Animal; Cholinergic Agents; Cotinine; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Evoked Potentials; Humans; Indans; Male; Memory; Oocytes; Pattern Recognition, Visual; Piperidines; Rats, Wistar; Receptors, Nicotinic; Stereoisomerism; Xenopus laevis | 2015 |
Cholinergic properties of new 7-methoxytacrine-donepezil derivatives.
Topics: Animals; Cells, Cultured; Cholinergic Antagonists; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Muscarinic Antagonists; Muscle Fibers, Skeletal; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Tacrine | 2015 |
Donepezil can improve daily activities and promote rehabilitation for severe Alzheimer's patients in long-term care health facilities.
Topics: Activities of Daily Living; Alzheimer Disease; Cholinesterase Inhibitors; Dementia; Disease Progression; Donepezil; Female; Humans; Indans; Long-Term Care; Male; Nursing Homes; Piperidines; Prospective Studies; Severity of Illness Index; Treatment Outcome | 2014 |
Bone Marrow-Derived Endothelial Progenitor Cells Protect Against Scopolamine-Induced Alzheimer-Like Pathological Aberrations.
Topics: Adipose Tissue; Alzheimer Disease; Animals; Cell Movement; Cells, Cultured; Cognition Disorders; Cytokines; Disease Models, Animal; Donepezil; Endothelial Progenitor Cells; Gene Expression Profiling; Hippocampus; Indans; Intercellular Signaling Peptides and Proteins; Learning Disabilities; Male; Maze Learning; Mesenchymal Stem Cell Transplantation; Nerve Tissue Proteins; Neurotransmitter Agents; Piperidines; Random Allocation; Rats; Rats, Wistar; Scopolamine | 2016 |
Sulfonamides as multifunctional agents for Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Binding Sites; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Free Radical Scavengers; Humans; Indans; Molecular Dynamics Simulation; Piperidines; Protein Binding; Sulfonamides | 2015 |
Imaging acetylcholinesterase density in peripheral organs in Parkinson's disease with 11C-donepezil PET.
Topics: Acetylcholinesterase; Adult; Aged; Antiparkinson Agents; Brain; Case-Control Studies; Cholinesterase Inhibitors; Constipation; Digestive System; Donepezil; Female; Heart Rate; Humans; Indans; Male; Middle Aged; Parkinson Disease; Piperidines; Positron-Emission Tomography; Surveys and Questionnaires; Time Factors | 2015 |
Divergent effects of the 'biased' 5-HT1 A receptor agonists F15599 and F13714 in a novel object pattern separation task.
Topics: Aminopyridines; Animals; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Indans; Male; Pattern Recognition, Visual; Piperazines; Piperidines; Pyridines; Pyrimidines; Rats; Serotonin 5-HT1 Receptor Agonists; Serotonin Antagonists | 2015 |
Donepezil-ferulic acid hybrids as anti-Alzheimer drugs.
Topics: Alzheimer Disease; Antioxidants; Butyrylcholinesterase; Cholinesterase Inhibitors; Coumaric Acids; Donepezil; Humans; Indans; Piperidines | 2015 |
Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer’s Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Apolipoproteins E; Apoptosis; Cholinesterase Inhibitors; Cytochrome P-450 CYP2D6; Donepezil; Fas Ligand Protein; Female; Humans; Indans; Longitudinal Studies; Male; Mental Status Schedule; Meta-Analysis as Topic; Pharmacogenetics; Piperidines; Polymorphism, Genetic; Predictive Value of Tests; Treatment Outcome; Tumor Necrosis Factor-alpha | 2015 |
Combination Therapy of Cholinesterase Inhibitor (Donepezil or Galantamine) plus Memantine in the Okayama Memantine Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Dopamine Agents; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female; Galantamine; Humans; Indans; Japan; Male; Memantine; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales | 2015 |
Combination benefit of cognitive rehabilitation plus donepezil for Alzheimer's disease patients.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Behavioral Therapy; Combined Modality Therapy; Donepezil; Humans; Indans; Piperidines; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2016 |
Donepezil improves learning and memory deficits in APP/PS1 mice by inhibition of microglial activation.
Topics: Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Antigens, CD; Antigens, Differentiation, Myelomonocytic; Brain; Cytokines; Donepezil; Indans; Learning Disabilities; Male; Maze Learning; Memory Disorders; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neurites; Nootropic Agents; Peptide Fragments; Piperidines; Plaque, Amyloid; Presenilin-1; Random Allocation; Recognition, Psychology | 2015 |
The effects of novel 7-MEOTA-donepezil like hybrids and N-alkylated tacrine analogues in the treatment of quinuclidinyl benzilate-induced behavioural deficits in rats performing the multiple T-maze test.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Male; Maze Learning; Muscarinic Antagonists; Nootropic Agents; Piperidines; Quinuclidinyl Benzilate; Rats, Wistar; Tacrine | 2015 |
The combination of aricept with a traditional Chinese medicine formula, smart soup, may be a novel way to treat Alzheimer's disease.
Topics: Aged; Alzheimer Disease; Amyloid beta-Peptides; Animals; Animals, Genetically Modified; Brain; Disease Models, Animal; Donepezil; Drosophila; Drug Therapy, Combination; Drugs, Chinese Herbal; Humans; Indans; Medicine, Chinese Traditional; Neurons; Nootropic Agents; Piperidines; Retrospective Studies; Treatment Outcome | 2015 |
[Severe bradycardia in general anaesthesia in a patient treated with cholinesterase inhibitors for dementia].
Topics: Aged; Anesthesia, General; Anesthetics, Intravenous; Bradycardia; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Interactions; Drug Therapy, Combination; Electrocardiography; Humans; Indans; Male; Piperidines; Propofol; Remifentanil | 2015 |
Donepezil rescues spatial learning and memory deficits following traumatic brain injury independent of its effects on neurogenesis.
Topics: Animals; Brain Injuries; Dentate Gyrus; Disease Models, Animal; Donepezil; Female; Ganciclovir; Indans; Male; Maze Learning; Memory Disorders; Mice; Mice, Transgenic; Neurogenesis; Piperidines; Spatial Learning; Valganciclovir | 2015 |
[Test scores as indicators of treatment efficacy in dementia caused by Alzheimer's disease in clinical practice].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines; Psychiatric Status Rating Scales; Treatment Outcome | 2014 |
Increased libido associated with donepezil treatment: a case report.
Topics: Alzheimer Disease; Antidepressive Agents, Tricyclic; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Libido; Piperidines; Sleep Initiation and Maintenance Disorders; Thiazepines; Treatment Outcome | 2016 |
Donepezil attenuates Aβ-associated mitochondrial dysfunction and reduces mitochondrial Aβ accumulation in vivo and in vitro.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Amyloid beta-Protein Precursor; Animals; Brain; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Male; Mice, Transgenic; Mitochondria; Neuroprotective Agents; Piperidines; Presenilin-1; Random Allocation; Rats, Sprague-Dawley | 2015 |
Donepezil treatment in ethnically diverse patients with Alzheimer disease.
Topics: Aged; Alzheimer Disease; Donepezil; Ethnicity; Female; Humans; Indans; Male; Nootropic Agents; Piperidines; Prospective Studies; Treatment Outcome | 2015 |
Challenges in the management of delirium: a case of augmentation with donepezil following inadequate response and adverse effects with risperidone.
Topics: Anticholinergic Syndrome; Antiparkinson Agents; Antipsychotic Agents; Biperiden; Burns; Cholinesterase Inhibitors; Delirium; Diagnosis, Differential; Donepezil; Drug Administration Routes; Drug Synergism; Humans; Indans; Male; Middle Aged; Muscle Rigidity; Physostigmine; Piperidines; Risperidone; Treatment Outcome | 2015 |
Donepezil-related intractable hiccups: a case report.
Topics: Aged; Donepezil; Fatal Outcome; Hiccup; Humans; Indans; Male; Nootropic Agents; Piperidines | 2015 |
Acetylcholinesterase Inhibition Attenuates the Development of Hypertension and Inflammation in Spontaneously Hypertensive Rats.
Topics: Animals; Blood Pressure; Cholinesterase Inhibitors; Cytokines; Donepezil; Drug Evaluation, Preclinical; Heart; Heart Rate; Hypertension; Indans; Inflammation; Male; Piperidines; Pyridostigmine Bromide; Rats, Inbred SHR; Rats, Inbred WKY; Ventricular Remodeling | 2015 |
Multigram synthesis and in vivo efficacy studies of a novel multitarget anti-Alzheimer's compound.
Topics: Alzheimer Disease; Aminoquinolines; Amyloid beta-Protein Precursor; Animals; Animals, Genetically Modified; Brain; Caenorhabditis elegans; Disease Models, Animal; Donepezil; Hep G2 Cells; Heterocyclic Compounds, 4 or More Rings; Humans; Indans; Mice; Molecular Structure; Piperidines | 2015 |
Galantamine improves sleep quality in patients with dementia.
Topics: Aged; Aged, 80 and over; Chi-Square Distribution; Cholinesterase Inhibitors; Dementia; Donepezil; Dose-Response Relationship, Drug; Female; Galantamine; Humans; Indans; Male; Piperidines; Rivastigmine; Severity of Illness Index; Sleep Wake Disorders; Treatment Outcome | 2015 |
Age-Related Decline in Brain and Hepatic Clearance of Amyloid-Beta is Rectified by the Cholinesterase Inhibitors Donepezil and Rivastigmine in Rats.
Topics: Aging; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Donepezil; Enzyme-Linked Immunosorbent Assay; Indans; Liver; Male; Piperidines; Rats; Rats, Sprague-Dawley; Rivastigmine | 2015 |
[ApoE gene polymorphism as a predictor of therapeutic response to treatment acetylcholinesterase inhibitor for elderly patients with Alzheimer's and vascular dementia types].
Topics: Aged; Alzheimer Disease; Apolipoproteins E; Cholinesterase Inhibitors; Dementia, Vascular; Donepezil; Female; Humans; Indans; Male; Piperidines; Polymorphism, Genetic; Treatment Outcome | 2014 |
The selective positive allosteric M1 muscarinic receptor modulator PQCA attenuates learning and memory deficits in the Tg2576 Alzheimer's disease mouse model.
Topics: Aging; Alzheimer Disease; Animals; Cholinergic Agents; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Drug Therapy, Combination; Female; Indans; Memory Disorders; Mice, Transgenic; Nootropic Agents; Piperidines; Quinolizines; Receptor, Muscarinic M1; Recognition, Psychology | 2015 |
Donepezil reverses intermittent stress-induced generalized chronic pain syndrome in mice.
Topics: Analgesics, Opioid; Animals; Chronic Pain; Donepezil; Fibromyalgia; Hyperalgesia; Indans; Injections, Intraventricular; Male; Mice; Mice, Inbred C57BL; Morphine; Muscarinic Agonists; Nootropic Agents; Pain Measurement; Pilocarpine; Piperidines; Stress, Psychological | 2015 |
Minocycline enhances hippocampal memory, neuroplasticity and synapse-associated proteins in aged C57 BL/6 mice.
Topics: Aging; Animals; Avoidance Learning; Brain-Derived Neurotrophic Factor; Cytoskeletal Proteins; Dendritic Spines; Donepezil; Early Growth Response Protein 1; Hippocampus; Indans; Long-Term Potentiation; Male; MAP Kinase Signaling System; Maze Learning; Memory; Mice; Mice, Inbred C57BL; Minocycline; Nerve Tissue Proteins; Neurons; Nootropic Agents; Piperidines; Synapses | 2015 |
Interaction between anti-Alzheimer and antipsychotic drugs in modulating extrapyramidal motor disorders in mice.
Topics: Alzheimer Disease; Animals; Antipsychotic Agents; Basal Ganglia Diseases; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Interactions; Galantamine; Haloperidol; Hypokinesia; Indans; Male; Mice, Inbred Strains; Nootropic Agents; Piperidines; Receptor, Serotonin, 5-HT1A; Receptors, Muscarinic; Serotonin Agents | 2015 |
Memory restorative ability of clioquinol in copper-cholesterol-induced experimental dementia in mice.
Topics: Acetylcholinesterase; Animals; Anticholesteremic Agents; Antioxidants; Behavior, Animal; Biomarkers; Brain; Cholesterol; Cholinesterase Inhibitors; Clioquinol; Copper; Dementia; Disease Models, Animal; Donepezil; Female; Glutathione; GPI-Linked Proteins; Indans; Male; Maze Learning; Memory; Mice; Nootropic Agents; Oxidative Stress; Piperidines; Superoxide Dismutase; Thiobarbituric Acid Reactive Substances; Time Factors | 2015 |
Synthesis of new N-benzylpiperidine derivatives as cholinesterase inhibitors with β-amyloid anti-aggregation properties and beneficial effects on memory in vivo.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Humans; Indans; Indoles; Male; Memory; Mice; Models, Molecular; Neuroprotective Agents; Phthalimides; Piperidines; Protein Aggregates; Scopolamine; Structure-Activity Relationship | 2015 |
Can donepezil facilitate weaning from mechanical ventilation in difficult to wean patients? An interventional pilot study.
Topics: Adult; Aged; Aged, 80 and over; Donepezil; Female; Humans; Indans; Male; Middle Aged; Pilot Projects; Piperidines; Respiratory Insufficiency; Treatment Outcome; Ventilator Weaning; Young Adult | 2015 |
Continuous treatment with antidementia drugs in Germany 2003-2013: a retrospective database analysis.
Topics: Age Factors; Aged; Aged, 80 and over; Databases, Factual; Dementia; Donepezil; Female; Germany; Humans; Indans; Kaplan-Meier Estimate; Male; Memantine; Middle Aged; Nootropic Agents; Piperidines; Practice Patterns, Physicians'; Retrospective Studies | 2015 |
Donepezil distribution in postmortem cases and potential for redistribution.
Topics: Aged, 80 and over; Blood Chemical Analysis; Cholinesterase Inhibitors; Chromatography, Liquid; Donepezil; Female; Forensic Toxicology; Humans; Hydrogen-Ion Concentration; Indans; Liver; Mass Spectrometry; Piperidines; Postmortem Changes; Tissue Distribution | 2015 |
Risk of pneumonia in new users of cholinesterase inhibitors for dementia.
Topics: Aged; Aged, 80 and over; Cholinesterase Inhibitors; Cohort Studies; Dementia; Donepezil; Female; Galantamine; Humans; Indans; Male; Phenylcarbamates; Piperidines; Pneumonia; Retrospective Studies; Risk Assessment; Rivastigmine | 2015 |
Additional donepezil treatment for patients with geriatric depression who exhibit cognitive deficit during treatment for depression.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Depression; Donepezil; Female; Geriatric Assessment; Humans; Indans; Male; Nootropic Agents; Piperidines; Retrospective Studies; Severity of Illness Index; Treatment Outcome | 2016 |
Increased iPLA2 activity and levels of phosphorylated GSK3B in platelets are associated with donepezil treatment in Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Analysis of Variance; Blood Platelets; Cholinesterase Inhibitors; Donepezil; Female; Glycogen Synthase Kinase 3; Group VI Phospholipases A2; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Phosphorylation; Piperidines; Time Factors | 2015 |
The influence of cholinesterase inhibitor therapy for dementia on risk of cardiac pacemaker insertion: a retrospective, population-based, health administrative databases study in Ontario, Canada.
Topics: Aged; Cholinesterase Inhibitors; Comorbidity; Databases, Factual; Dementia; Donepezil; Female; Galantamine; Health Services Research; Humans; Indans; Male; Ontario; Pacemaker, Artificial; Piperidines; Prosthesis Implantation; Retrospective Studies; Risk; Rivastigmine | 2015 |
[Design, synthesis and biological evaluation of novel [1,3] dioxolo [4,5-f]isoindolone derivatives].
Topics: Animals; Cholinesterase Inhibitors; Dioxoles; Donepezil; Drug Design; Indans; Inhibitory Concentration 50; Isoindoles; Memory Disorders; Mice; Piperidines; Scopolamine | 2015 |
Antidementia drug treatment in dementia networks in Germany: use rates and factors associated with treatment use.
Topics: Aged; Aged, 80 and over; Caregivers; Cholinesterase Inhibitors; Dementia; Donepezil; Dopamine Agents; Female; Galantamine; Germany; Humans; Indans; Interviews as Topic; Logistic Models; Male; Memantine; Neuroprotective Agents; Nootropic Agents; Piperidines; Rivastigmine | 2015 |
The Relationship Between Medial Temporal Lobe Atrophy and Cognitive Impairment in Patients With Dementia With Lewy Bodies.
Topics: Age of Onset; Aged; Aged, 80 and over; Alzheimer Disease; Amygdala; Atrophy; Cognition Disorders; Donepezil; Entorhinal Cortex; Female; Hippocampus; Humans; Indans; Language; Lewy Body Disease; Magnetic Resonance Imaging; Male; Mental Recall; Neuropsychological Tests; Nootropic Agents; Piperidines; Software; Temporal Lobe; Verbal Behavior | 2015 |
Nootropic, neuroprotective and neurotrophic effects of phloretin in scopolamine induced amnesia in mice.
Topics: Acetylcholinesterase; Alzheimer Disease; Amnesia; Animals; Antioxidants; Brain-Derived Neurotrophic Factor; Cognition Disorders; Donepezil; Glial Fibrillary Acidic Protein; Indans; Male; Maze Learning; Mice; Motor Activity; Muscarinic Agonists; Neuroprotective Agents; Nootropic Agents; Phloretin; Piperidines; Scopolamine | 2015 |
The Effects of Anti-Dementia and Nootropic Treatments on the Mortality of Patients with Dementia: A Population-Based Cohort Study in Taiwan.
Topics: Cohort Studies; Dementia; Dihydroergocristine; Dihydroergotamine; Donepezil; Galantamine; Humans; Indans; Memantine; Neuroprotective Agents; Nootropic Agents; Piperidines; Piracetam; Proportional Hazards Models; Retrospective Studies; Rivastigmine; Taiwan; Time Factors | 2015 |
Disease state changes and safety of long-term donepezil hydrochloride administration in patients with Alzheimer's disease: interim results from the long-term, large-scale J-GOLD study in Japan.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Humans; Indans; Japan; Long-Term Care; Male; Mental Status Schedule; Middle Aged; Piperidines; Prospective Studies; Treatment Outcome | 2016 |
Donepezil Regulates 1-Methyl-4-phenylpyridinium-Induced Microglial Polarization in Parkinson's Disease.
Topics: 1-Methyl-4-phenylpyridinium; Analysis of Variance; Animals; Arginase; beta-N-Acetylhexosaminidases; Cell Line, Transformed; Cell Polarity; Cell Survival; Cytokines; Donepezil; Dose-Response Relationship, Drug; Herbicides; Indans; Intercellular Signaling Peptides and Proteins; Lectins; Macrophages; Mice; Microglia; Nootropic Agents; Piperidines; RNA, Messenger; STAT6 Transcription Factor | 2015 |
Predicting the neural effect of switching from donepezil to galantamine based on single-photon emission computed tomography findings in patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apathy; Cholinesterase Inhibitors; Donepezil; Executive Function; Female; Galantamine; Humans; Indans; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Piperidines; Prospective Studies; Tomography, Emission-Computed, Single-Photon | 2016 |
Distinctive Effect of Donepezil Treatment on P300 and N200 Subcomponents of Auditory Event-Related Evoked Potentials in Alzheimer Disease Patients.
Topics: Aged; Alzheimer Disease; Case-Control Studies; Cholinesterase Inhibitors; Donepezil; Event-Related Potentials, P300; Evoked Potentials; Female; Humans; Indans; Male; Piperidines | 2015 |
Effects of donepezil and serotonin reuptake inhibitor on acute regression during adolescence in Down syndrome.
Topics: Adolescent; Brain; Disease Progression; Donepezil; Down Syndrome; Electroencephalography; Humans; Indans; Male; Nootropic Agents; Piperidines; Selective Serotonin Reuptake Inhibitors; Treatment Outcome | 2016 |
Protective effect of berberine, an isoquinoline alkaloid ameliorates ethanol-induced oxidative stress and memory dysfunction in rats.
Topics: Animals; Ascorbic Acid; Behavior, Animal; Berberine; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Ethanol; Glutathione; Hippocampus; Indans; Lipid Peroxidation; Male; Memory Disorders; Oxidative Stress; Piperidines; Rats | 2015 |
Normal Hearing Ability but Impaired Auditory Selective Attention Associated with Prediction of Response to Donepezil in Patients with Alzheimer's Disease.
Topics: Adult; Aged; Aged, 80 and over; Alzheimer Disease; Attention; Cholinesterase Inhibitors; Donepezil; Female; Hearing; Humans; Indans; Male; Middle Aged; Neuropsychological Tests; Piperidines | 2015 |
Donepezil increases contrast sensitivity for the detection of objects in scenes.
Topics: Adult; Cholinergic Antagonists; Cholinesterase Inhibitors; Contrast Sensitivity; Donepezil; Humans; Indans; Male; Pattern Recognition, Visual; Piperidines; Reaction Time; Scopolamine; Signal Detection, Psychological; Young Adult | 2015 |
Neuroprotection of donepezil against morphine-induced apoptosis is mediated through Toll-like receptors.
Topics: Analgesics, Opioid; Animals; Apoptosis; bcl-2-Associated X Protein; Donepezil; Drug Tolerance; Frontal Lobe; Gene Expression; Indans; Lumbar Vertebrae; Male; Morphine; Neuroprotective Agents; Pain; Piperidines; Proto-Oncogene Proteins c-bcl-2; Rats, Wistar; RNA, Messenger; Spinal Cord; Toll-Like Receptors | 2015 |
Increased dosage of donepezil for the management of behavioural and psychological symptoms of dementia in dementia with Lewy bodies.
Topics: Aged; Aged, 80 and over; Behavior; Behavioral Symptoms; Cholinesterase Inhibitors; Cognition; Dementia; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indans; Lewy Body Disease; Male; Middle Aged; Piperidines; Severity of Illness Index; Treatment Outcome | 2016 |
Donepezil attenuates high glucose-accelerated senescence in human umbilical vein endothelial cells through SIRT1 activation.
Topics: Cells, Cultured; Cellular Senescence; Cholinesterase Inhibitors; Donepezil; Glucose; Human Umbilical Vein Endothelial Cells; Humans; Indans; Niacinamide; Piperidines; Plasminogen Activator Inhibitor 1; Reactive Oxygen Species; Sirtuin 1 | 2015 |
An unusual cardiovascular adverse effect of donepezil.
Topics: Arrhythmias, Cardiac; Cholinesterase Inhibitors; Dementia; Donepezil; Electrocardiography; Female; Humans; Indans; Middle Aged; Piperidines | 2015 |
Molecular imaging of cholinergic processes in prostate cancer using ¹¹C-donepezil and ¹⁸F-FEOBV.
Topics: Aged; Carbon Radioisotopes; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Male; Middle Aged; Neoplasm Grading; Piperidines; Positron Emission Tomography Computed Tomography; Prostatic Neoplasms; Radiopharmaceuticals; Vesicular Acetylcholine Transport Proteins | 2016 |
Development of an LC-MS/MS method for simultaneous determination of memantine and donepezil in rat plasma and its application to pharmacokinetic study.
Topics: Animals; Chromatography, Liquid; Donepezil; Indans; Limit of Detection; Memantine; Nootropic Agents; Piperidines; Rats; Reproducibility of Results; Tandem Mass Spectrometry | 2015 |
Nicotinic acetylcholine receptors mediate donepezil-induced oligodendrocyte differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Central Nervous System; Donepezil; Female; Gene Expression; Indans; Mice; Multiple Sclerosis; Myelin Basic Protein; Neurogenesis; Oligodendroglia; Piperidines; Receptors, Nicotinic; Stem Cells | 2015 |
Adverse Drug Reactions Reported With Cholinesterase Inhibitors: An Analysis of 16 Years of Individual Case Safety Reports From VigiBase.
Topics: Adverse Drug Reaction Reporting Systems; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug-Related Side Effects and Adverse Reactions; Europe; Female; Galantamine; Humans; Indans; Male; Medication Errors; North America; Pharmacovigilance; Piperidines; Rivastigmine; World Health Organization | 2015 |
Beneficial Effect of Protein Tyrosine Phosphatase Inhibitor and Phytoestrogen in Dyslipidemia-Induced Vascular Dementia in Ovariectomized Rats.
Topics: Acetylcholinesterase; Animals; Avoidance Learning; Brain; Dementia, Vascular; Donepezil; Dyslipidemias; Enzyme Inhibitors; Female; Gene Expression Regulation; Genistein; Indans; Lipids; Mental Recall; Nitric Oxide Synthase Type III; Ovariectomy; Oxidative Stress; Phytoestrogens; Piperidines; Rats; Rats, Wistar; Reaction Time; Vanadates | 2015 |
Nicotinic α7 and α4β2 agonists enhance the formation and retrieval of recognition memory: Potential mechanisms for cognitive performance enhancement in neurological and psychiatric disorders.
Topics: Analysis of Variance; Animals; Antipsychotic Agents; Benzamides; Bridged Bicyclo Compounds; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Female; Indans; Locomotion; Mental Recall; Nicotine; Nicotinic Agonists; Piperidines; Rats; Recognition, Psychology; Retention, Psychology; Risperidone | 2016 |
Monitoring Plasma Levels of Donepezil, 5-O-Desmethyl-Donepezil, 6-O-Desmethyl-Donepezil, and Donepezil-N-Oxide by a Novel HPLC Method in Patients With Alzheimer Disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Chromatography, High Pressure Liquid; Cyclic N-Oxides; Donepezil; Drug Monitoring; Female; Humans; Indans; Liquid-Liquid Extraction; Male; Nootropic Agents; Piperidines | 2016 |
Protection by sigma-1 receptor agonists is synergic with donepezil, but not with memantine, in a mouse model of amyloid-induced memory impairments.
Topics: Amyloid beta-Peptides; Animals; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Synergism; Excitatory Amino Acid Antagonists; Furans; Indans; Male; Memantine; Memory Disorders; Mice; Morpholines; Neuroprotective Agents; Peptide Fragments; Piperidines; Receptors, N-Methyl-D-Aspartate; Receptors, sigma; Sigma-1 Receptor | 2016 |
Clinical Benefits of Rivastigmine in the Real World Dementia Clinics of the Okayama Rivastigmine Study (ORS).
Topics: Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Indans; Male; Mental Status Schedule; Nootropic Agents; Piperidines; Psychiatric Status Rating Scales; Retrospective Studies; Rivastigmine; Severity of Illness Index; Time Factors; Treatment Outcome | 2015 |
Clinical Benefits for Older Alzheimer's Disease Patients: Okayama Late Dementia Study (OLDS).
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Antipsychotic Agents; Donepezil; Female; Follow-Up Studies; Galantamine; Humans; Indans; Japan; Male; Memantine; Piperidines; Retrospective Studies; Rivastigmine; Treatment Outcome | 2015 |
Protective effects of NMDA receptor antagonist, memantine, against senescence of PC12 cells: A possible role of nNOS and combined effects with donepezil.
Topics: Aging; Alzheimer Disease; Animals; beta-Galactosidase; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Glutamic Acid; Hippocampus; Indans; Male; Maze Learning; Memantine; Memory; Mice; Neuronal Plasticity; Nitric Oxide Synthase Type I; PC12 Cells; Piperidines; Rats; Receptors, N-Methyl-D-Aspartate | 2015 |
The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function.
Topics: Animals; Attention; Cholinesterase Inhibitors; Conditioning, Operant; Discrimination Learning; Discrimination, Psychological; Donepezil; Drug Evaluation, Preclinical; Humans; Indans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nootropic Agents; Piperidines; Psychomotor Performance; Species Specificity; Visual Perception | 2015 |
Drug-induced lupus erythematosus associated with donepezil: a case report.
Topics: Aged, 80 and over; Alzheimer Disease; Donepezil; Female; Humans; Hydrolases; Indans; Lupus Erythematosus, Systemic; Nootropic Agents; Piperidines; Skin | 2015 |
A case of donepezil-related torsades de pointes.
Topics: Aged, 80 and over; Alzheimer Disease; Cardiopulmonary Resuscitation; Donepezil; Electrocardiography; Female; Humans; Indans; Long QT Syndrome; Nootropic Agents; Piperidines; Seizures; Syncope; Torsades de Pointes | 2015 |
The M1 Muscarinic Positive Allosteric Modulator PQCA Improves Performance on Translatable Tests of Memory and Attention in Rhesus Monkeys.
Topics: Animals; Association Learning; Attention; Cholinesterase Inhibitors; Cognition; Discrimination, Psychological; Donepezil; Dose-Response Relationship, Drug; Indans; Macaca mulatta; Male; Memory; Muscarinic Agonists; Muscarinic Antagonists; Piperidines; Psychomotor Performance; Quinolizines; Receptor, Muscarinic M1; Scopolamine | 2015 |
The dual-acting H3 receptor antagonist and AChE inhibitor UW-MD-71 dose-dependently enhances memory retrieval and reverses dizocilpine-induced memory impairment in rats.
Topics: Animals; Avoidance Learning; Benzothiazoles; Cholinesterase Inhibitors; Disease Models, Animal; Dizocilpine Maleate; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Histamine H3 Antagonists; Indans; Male; Memory; Memory Disorders; Nootropic Agents; Phenoxypropanolamines; Piperidines; Pyrilamine; Pyrroles; Quinazolines; Random Allocation; Rats, Wistar; Receptors, Histamine H3 | 2016 |
Local Drug-Drug Interaction of Donepezil with Cilostazol at Breast Cancer Resistance Protein (ABCG2) Increases Drug Accumulation in Heart.
Topics: Acridines; Administration, Intravenous; Administration, Oral; Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; ATP Binding Cassette Transporter, Subfamily G, Member 2; ATP-Binding Cassette Transporters; Biological Transport; Blood-Brain Barrier; Cardiotoxicity; Cholinesterase Inhibitors; Cilostazol; Dogs; Donepezil; Drug Interactions; Female; In Vitro Techniques; Indans; Madin Darby Canine Kidney Cells; Male; Models, Biological; Myocardium; Piperidines; Rats, Wistar; Tetrahydroisoquinolines; Tetrazoles; Tissue Distribution; Transfection | 2016 |
Donepezil-like multifunctional agents: Design, synthesis, molecular modeling and biological evaluation.
Topics: Acetylcholinesterase; Antioxidants; Chelating Agents; Chemistry Techniques, Synthetic; Donepezil; Drug Design; Humans; Indans; Molecular Docking Simulation; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Piperidines; Protein Conformation; Structure-Activity Relationship | 2016 |
Continuing donepezil when Alzheimer symptoms worsen might delay nursing home admission, study indicates.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Nootropic Agents; Nursing Homes; Patient Admission; Piperidines; Randomized Controlled Trials as Topic; Withholding Treatment | 2015 |
Synthesis of donepezil-based multifunctional agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Amides; Amyloid beta-Peptides; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Drug Design; Indans; Inhibitory Concentration 50; Models, Molecular; Piperidines; Structure-Activity Relationship | 2015 |
Antiaggregation Potential of Padina gymnospora against the Toxic Alzheimer's Beta-Amyloid Peptide 25-35 and Cholinesterase Inhibitory Property of Its Bioactive Compounds.
Topics: Acetone; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Microscopy, Confocal; Peptide Fragments; Piperidines; Plant Extracts; Protein Binding; Protein Structure, Secondary; Seaweed; Spectroscopy, Fourier Transform Infrared; Tandem Mass Spectrometry | 2015 |
Lifetime expectancy and quality-adjusted life-year in Alzheimer's disease with and without cerebrovascular disease: effects of nursing home replacement and donepezil administration--a retrospective analysis in the Tajiri Project.
Topics: Alzheimer Disease; Cerebrovascular Disorders; Cholinesterase Inhibitors; Comorbidity; Donepezil; Humans; Indans; Japan; Life Expectancy; Nursing Homes; Piperidines; Quality-Adjusted Life Years; Retrospective Studies | 2015 |
Donepezil May Reduce Insulin-Like Growth Factor-1 (IGF-1) Levels in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Biomarkers; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Insulin-Like Growth Factor I; Male; Piperidines | 2016 |
Efficacy of Donepezil for Cognitive Impairments in Familial Hypercholesterolemia: Preclinical Proof of Concept.
Topics: Animals; Cholinesterase Inhibitors; Cognition Disorders; Discrimination, Psychological; Disease Models, Animal; Donepezil; Drug Evaluation, Preclinical; Exploratory Behavior; Hyperlipoproteinemia Type II; Indans; Learning; Memory; Mice, Inbred C57BL; Mice, Knockout; Nootropic Agents; Piperidines; Psychological Tests; Receptors, LDL; Space Perception | 2015 |
Determination of affinity and efficacy of acetylcholinesterase inhibitors using isothermal titration calorimetry.
Topics: Acetylcholine; Acetylcholinesterase; Ambenonium Chloride; Animals; Calorimetry; Cholinesterase Inhibitors; Donepezil; Edrophonium; Electrophorus; Fish Proteins; Galantamine; Indans; Kinetics; Piperidines; Tacrine; Thermodynamics | 2016 |
Stereoselective metabolism of donepezil and steady-state plasma concentrations of S-donepezil based on CYP2D6 polymorphisms in the therapeutic responses of Han Chinese patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alleles; Alzheimer Disease; Asian People; Cholinesterase Inhibitors; Cytochrome P-450 CYP2D6; Donepezil; Female; Humans; Indans; Liver; Male; Microsomes, Liver; Nootropic Agents; Piperidines; Polymorphism, Genetic; Stereoisomerism; Treatment Outcome | 2015 |
Real-world evaluation of compliance and preference in Alzheimer's disease treatment.
Topics: Administration, Cutaneous; Administration, Oral; Aged; Aged, 80 and over; Alzheimer Disease; Asia; Attitude of Health Personnel; Caregivers; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Humans; Indans; Male; Medication Adherence; Memantine; Middle East; Patient Preference; Physicians; Piperidines; Prospective Studies; Rivastigmine | 2015 |
Effects of Ginkgo biloba Extract EGb 761, Donepezil and their Combination on Central Cholinergic Function in Aged Rats.
Topics: Acetylcholine; Aging; Animals; Brain; Choline; Choline O-Acetyltransferase; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Ginkgo biloba; Hippocampus; Indans; Male; Microdialysis; Neuroprotective Agents; Piperidines; Plant Extracts; Rats; Rats, Sprague-Dawley | 2015 |
Temporal trends for donepezil utilization among older people.
Topics: Adrenergic beta-Antagonists; Age Factors; Aged; Aged, 80 and over; Cross-Sectional Studies; Databases, Factual; Donepezil; Drug Therapy, Combination; Drug Utilization; Female; Humans; Indans; Male; New Zealand; Piperidines | 2016 |
Adverse Effects of Cholinesterase Inhibitors in Dementia, According to the Pharmacovigilance Databases of the United-States and Canada.
Topics: Adverse Drug Reaction Reporting Systems; Alzheimer Disease; Canada; Cholinesterase Inhibitors; Databases, Factual; Dementia; Donepezil; Galantamine; Humans; Indans; Pharmacovigilance; Piperidines; Rivastigmine; United States; United States Food and Drug Administration | 2015 |
Possible overlapping time frames of acquisition and consolidation phases in object memory processes: a pharmacological approach.
Topics: Animals; Cholinesterase Inhibitors; Discrimination, Psychological; Donepezil; Indans; Learning; Male; Memory; Phosphodiesterase 5 Inhibitors; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Rolipram; Scopolamine; Vardenafil Dihydrochloride | 2016 |
Cholinergic Neurotransmission in the Posterior Insular Cortex Is Altered in Preclinical Models of Neuropathic Pain: Key Role of Muscarinic M2 Receptors in Donepezil-Induced Antinociception.
Topics: Analgesics; Animals; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Gene Expression; Hyperalgesia; Indans; Interpersonal Relations; Male; Membrane Transport Proteins; Muscarinic Antagonists; Neuralgia; Organoplatinum Compounds; Oxaliplatin; Parasympathetic Nervous System; Piperidines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; RNA, Messenger; Synaptic Transmission | 2015 |
Effects of novel tacrine-related cholinesterase inhibitors in the reversal of 3-quinuclidinyl benzilate-induced cognitive deficit in rats--Is there a potential for Alzheimer's disease treatment?
Topics: Alzheimer Disease; Animals; Avoidance Learning; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Indans; Male; Maze Learning; Muscarinic Antagonists; Piperidines; Quinuclidinyl Benzilate; Rats, Wistar; Tacrine | 2016 |
Donepezil regulates energy metabolism and favors bone mass accrual.
Topics: Animals; Biomechanical Phenomena; Bone and Bones; Cell Count; Donepezil; Energy Metabolism; Female; Indans; Isoproterenol; Mice, Inbred C57BL; Organ Size; Osteoclasts; Piperidines | 2016 |
Cognitive effects of donepezil therapy in patients with brain tumors: a pilot study.
Topics: Adult; Aged; Aged, 80 and over; Brain Neoplasms; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Middle Aged; Neoplasm Staging; Neuropsychological Tests; Pilot Projects; Piperidines; Prognosis; Survival Rate; Survivors | 2016 |
Effect of Donepezil, Tacrine, Galantamine and Rivastigmine on Acetylcholinesterase Inhibition in Dugesia tigrina.
Topics: Animals; Cholinesterase Inhibitors; Convulsants; Donepezil; Galantamine; Indans; Locomotion; Models, Biological; Piperidines; Planarians; Rivastigmine; Seizures; Survival Rate; Tacrine | 2016 |
The roles of apolipoprotein E3 and CYP2D6 (rs1065852) gene polymorphisms in the predictability of responses to individualized therapy with donepezil in Han Chinese patients with Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Apolipoprotein E3; Asian People; Cytochrome P-450 CYP2D6; Donepezil; Female; Genotype; Humans; Indans; Male; Piperidines; Polymorphism, Genetic; Precision Medicine | 2016 |
Antidepressant, anxiolytic and procognitive effects of rivastigmine and donepezil in the chronic mild stress model in rats.
Topics: Anhedonia; Animals; Antidepressive Agents; Cholinesterase Inhibitors; Cognitive Dysfunction; Depressive Disorder; Disease Models, Animal; Donepezil; Indans; Male; Nootropic Agents; Piperidines; Rats; Rats, Wistar; Recognition, Psychology; Rivastigmine; Stress, Psychological | 2016 |
Repeated administration of an acetylcholinesterase inhibitor attenuates nicotine taking in rats and smoking behavior in human smokers.
Topics: Adolescent; Adult; Animals; Cholinesterase Inhibitors; Donepezil; Female; Galantamine; Humans; Indans; Male; Middle Aged; Nicotine; Piperidines; Rats; Smoking Prevention; Young Adult | 2016 |
The PDE4 inhibitor roflumilast improves memory in rodents at non-emetic doses.
Topics: Aminopyridines; Animals; Benzamides; Cyclopropanes; Donepezil; Indans; Male; Memory; Mice; Mice, Inbred C57BL; Nootropic Agents; Phosphodiesterase 4 Inhibitors; Piperidines; Rats, Wistar; Recognition, Psychology; Rolipram; Scopolamine; Spatial Memory; Vomiting | 2016 |
Preparation, characterization, and in vivo evaluation of intranasally administered liposomal formulation of donepezil.
Topics: Administration, Intranasal; Administration, Oral; Animals; Biological Availability; Brain; Chemistry, Pharmaceutical; Cholesterol; Delayed-Action Preparations; Donepezil; Drug Carriers; Drug Delivery Systems; Indans; Liposomes; Male; Nootropic Agents; Particle Size; Phosphatidylcholines; Piperidines; Polyethylene Glycols; Rats; Rats, Wistar; Tissue Distribution | 2016 |
Exploring the Phase Behavior of Monoolein/Oleic Acid/Water Systems for Enhanced Donezepil Administration for Alzheimer Disease Treatment.
Topics: Adhesiveness; Alzheimer Disease; Animals; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Delayed-Action Preparations; Donepezil; Drug Carriers; Drug Liberation; Glycerides; Humans; In Vitro Techniques; Indans; Intestinal Mucosa; Models, Theoretical; Nanostructures; Oleic Acid; Phase Transition; Piperidines; Solubility; Swine; Water | 2016 |
Donepezil: rhabdomyolysis and neuroleptic malignant syndrome.
Topics: Cholinesterase Inhibitors; Donepezil; Humans; Indans; Neuroleptic Malignant Syndrome; Piperidines; Rhabdomyolysis | 2015 |
Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Cell Line, Tumor; Cell Survival; Chelating Agents; Cholinesterase Inhibitors; Clioquinol; Copper; Donepezil; Drug Design; Human Umbilical Vein Endothelial Cells; Humans; Indans; Oxyquinoline; Piperidines; Structure-Activity Relationship; Zinc | 2016 |
Mild versus moderate stages of Alzheimer's disease: three-year outcomes in a routine clinical setting of cholinesterase inhibitor therapy.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Female; Galantamine; Humans; Indans; Male; Mental Status Schedule; Piperidines; Prospective Studies; Rivastigmine; Severity of Illness Index; Treatment Outcome | 2016 |
Donepezil loaded PLGA-b-PEG nanoparticles: their ability to induce destabilization of amyloid fibrils and to cross blood brain barrier in vitro.
Topics: Amyloid; Amyloid beta-Peptides; Astrocytes; Blood-Brain Barrier; Capillary Permeability; Cell Line; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Carriers; Endothelial Cells; Gene Expression; Humans; Indans; Nanoparticles; Neuroprotective Agents; Peptide Fragments; Piperidines; Polyethylene Glycols; Polyglactin 910; Protein Stability; Rifampin | 2017 |
Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Line, Tumor; Cholinesterase Inhibitors; Cholinesterases; Coumarins; Donepezil; Dose-Response Relationship, Drug; Drug Design; Eels; Humans; Indans; Models, Molecular; Molecular Structure; Molecular Targeted Therapy; Piperidines; Structure-Activity Relationship | 2016 |
Characteristics of Pediatric Exposures to Antidementia Drugs Reported to a Poison Control System.
Topics: Child; Child, Preschool; Dementia; Donepezil; Female; Galantamine; Humans; Indans; Infant; Male; Memantine; Nootropic Agents; Piperidines; Poison Control Centers; Retrospective Studies; Rivastigmine | 2016 |
Effect and mechanism of fuzhisan and donepezil on the sirtuin 1 pathway and amyloid precursor protein metabolism in PC12 cells.
Topics: ADAM10 Protein; Amyloid Precursor Protein Secretases; Animals; Blotting, Western; Donepezil; Drugs, Chinese Herbal; Enzyme-Linked Immunosorbent Assay; Forkhead Transcription Factors; Indans; PC12 Cells; Piperidines; Rats; Signal Transduction; Sirtuin 1 | 2016 |
Determination of donepezil in serum samples using molecularly imprinted polymer nanoparticles followed by high-performance liquid chromatography with ultraviolet detection.
Topics: Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Indans; Molecular Imprinting; Nanoparticles; Piperidines; Polymers | 2016 |
Cholinergic modulation of auditory steady-state response in the auditory cortex of the freely moving rat.
Topics: Acoustic Stimulation; Animals; Auditory Cortex; Cholinergic Antagonists; Cholinesterase Inhibitors; Donepezil; Electrodes, Implanted; Indans; Male; Microelectrodes; Piperidines; Rats, Wistar; Scopolamine | 2016 |
Effects of Acetylcholinesterase Inhibitors on Nutritional Status in Elderly Patients with Dementia: A 6-month Follow-up Study.
Topics: Acetylcholinesterase; Activities of Daily Living; Aged; Body Mass Index; Body Weight; Cholinesterase Inhibitors; Dementia; Disease Progression; Donepezil; Eating; Female; Follow-Up Studies; Galantamine; Geriatric Assessment; Humans; Indans; Male; Nutrition Assessment; Nutritional Status; Piperidines; Polypharmacy; Retrospective Studies; Rivastigmine | 2016 |
Cholinesterase Inhibitor Donepezil Increases Mitochondrial Biogenesis through AMP-Activated Protein Kinase in the Hippocampus.
Topics: Adenosine Triphosphate; AMP-Activated Protein Kinases; Animals; Cell Line, Tumor; Cholinesterase Inhibitors; Dendrites; Donepezil; Dose-Response Relationship, Drug; Female; Hippocampus; Humans; Indans; Male; Mice, Inbred ICR; Mitochondria; Nuclear Respiratory Factor 1; Organelle Biogenesis; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Piperidines; Rats, Sprague-Dawley; RNA, Messenger; Tissue Culture Techniques | 2016 |
Microneedle-mediated delivery of donepezil: Potential for improved treatment options in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Area Under Curve; Cholinesterase Inhibitors; Donepezil; Indans; Male; Microinjections; Needles; Piperidines; Rats; Rats, Sprague-Dawley | 2016 |
An HPLC-MS method for the quantification of new acetylcholinesterase inhibitor PC 48 (7-MEOTA-donepezil like compound) in rat plasma: Application to a pharmacokinetic study.
Topics: Alzheimer Disease; Animals; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity; Tacrine; Tandem Mass Spectrometry | 2016 |
Sunitinib, a Clinically Used Anticancer Drug, Is a Potent AChE Inhibitor and Attenuates Cognitive Impairments in Mice.
Topics: Acetylcholinesterase; Animals; Antineoplastic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Exploratory Behavior; Indans; Indoles; Male; Maze Learning; Mice; Mice, Inbred ICR; Molecular Docking Simulation; Piperidines; Pyrroles; Scopolamine; Sunitinib | 2016 |
Protective effect of transient receptor potential vanilloid subtype 1 (TRPV1) modulator, against behavioral, biochemical and structural damage in experimental models of Alzheimer's disease.
Topics: Aluminum Chloride; Aluminum Compounds; Alzheimer Disease; Animals; Benzaldehydes; Brain; Chlorides; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Galactose; Indans; Mice; Neuroprotective Agents; Nootropic Agents; Piperidines; Streptozocin; TRPV Cation Channels | 2016 |
Acquisition and reinstatement of ethanol-induced conditioned place preference in rats: Effects of the cholinesterase inhibitors donepezil and rivastigmine.
Topics: Animals; Cholinesterase Inhibitors; Conditioning, Psychological; Donepezil; Ethanol; Indans; Male; Mecamylamine; Muscarinic Antagonists; Nicotinic Antagonists; Piperidines; Rats; Rats, Wistar; Receptors, Nicotinic; Reinforcement, Psychology; Rivastigmine; Scopolamine | 2016 |
Polyurethane/hydroxypropyl cellulose electrospun nanofiber mats as potential transdermal drug delivery system: characterization studies and in vitro assays.
Topics: Animals; Cell Survival; Cellulose; Donepezil; Drug Carriers; Drug Compounding; Drug Liberation; Electrochemical Techniques; Indans; Kinetics; Membranes, Artificial; Mice; Molecular Mimicry; Nanofibers; NIH 3T3 Cells; Nootropic Agents; Permeability; Piperidines; Polyurethanes; Skin | 2017 |
Effects of donepezil on brain morphometric and metabolic changes in patients with Alzheimer's disease: A DARTEL-based VBM and (1)H-MRS.
Topics: Aged; Alzheimer Disease; Brain; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Organ Size; Piperidines; Proton Magnetic Resonance Spectroscopy; Severity of Illness Index | 2016 |
Postmortem redistribution mechanism of donepezil in the rat.
Topics: Alzheimer Disease; Animals; Autopsy; Blood Chemical Analysis; Cholinesterase Inhibitors; Donepezil; Hydrogen-Ion Concentration; Indans; Piperidines; Postmortem Changes; Rats; Time Factors; Tissue Distribution | 2016 |
Neuroprotective effects of Danggui-Jakyak-San on rat stroke model through antioxidant/antiapoptotic pathway.
Topics: Animals; Antioxidants; Apoptosis; Behavior, Animal; Biomarkers; Caspase 3; Cerebral Cortex; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drugs, Chinese Herbal; Indans; Infarction, Middle Cerebral Artery; Lipid Peroxidation; Male; Motor Activity; Nerve Degeneration; Neuroprotective Agents; Oxidative Stress; Piperidines; Poly(ADP-ribose) Polymerases; Proto-Oncogene Proteins c-pim-1; Rats, Sprague-Dawley; Signal Transduction; STAT3 Transcription Factor; Time Factors | 2016 |
Simultaneous Determination of Donepezil and Its Three Metabolites in Human Plasma Using LC-MS-MS.
Topics: Blood Chemical Analysis; Chromatography, Liquid; Donepezil; Humans; Indans; Piperidines; Reproducibility of Results; Tandem Mass Spectrometry | 2016 |
Cholinergic enhancement increases regional cerebral blood flow to the posterior cingulate cortex in mild Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Follow-Up Studies; Gyrus Cinguli; Humans; Indans; Male; Piperidines; Prospective Studies; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2017 |
Hepatotoxicity Associated with Donepezil in an Individual Taking Citalopram.
Topics: Aged, 80 and over; Alzheimer Disease; Antidepressive Agents, Second-Generation; Chemical and Drug Induced Liver Injury; Citalopram; Donepezil; Drug Therapy, Combination; Female; Humans; Indans; Nootropic Agents; Piperidines | 2016 |
Novel anionic polymer as a carrier for CNS delivery of anti-Alzheimer drug.
Topics: Alzheimer Disease; Animals; Anions; Cell Line, Tumor; Central Nervous System; Central Nervous System Agents; Donepezil; Drug Carriers; Drug Delivery Systems; Emulsions; Gels; Humans; Indans; Nanoparticles; Particle Size; Piperidines; Polymers; Rats; Rats, Wistar | 2016 |
Unexplained Homonymous Hemianopia.
Topics: Alzheimer Disease; Atrophy; Cholinesterase Inhibitors; Donepezil; Female; Hemianopsia; Humans; Indans; Magnetic Resonance Imaging; Middle Aged; Neuropsychological Tests; Occipital Lobe; Parietal Lobe; Piperidines; Visual Field Tests; Visual Fields | 2016 |
Epidemiological Characteristics of Dementia Treatment in Croatia.
Topics: Adult; Aged; Aged, 80 and over; Croatia; Databases, Factual; Dementia; Donepezil; Dopamine Agents; Female; Hospitalization; Humans; Indans; Male; Memantine; Middle Aged; Nootropic Agents; Pharmacoepidemiology; Piperidines; Young Adult | 2016 |
Tip-loaded dissolving microneedles for transdermal delivery of donepezil hydrochloride for treatment of Alzheimer's disease.
Topics: Administration, Cutaneous; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Needles; Piperidines; Solubility | 2016 |
Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse.
Topics: Animals; Benzofurans; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Drug Inverse Agonism; Histamine; Histamine H3 Antagonists; Histidine Decarboxylase; Indans; Male; Mice; Mice, Knockout; Nootropic Agents; Piperidines; Pyrrolidines; Receptors, Histamine H3 | 2016 |
DatSCAN In Differential Diagnostics of Lewy Body Disease.
Topics: Aged, 80 and over; Alzheimer Disease; Czech Republic; Diagnosis, Differential; Donepezil; Female; Humans; Indans; Lewy Body Disease; Piperidines; Synaptic Transmission; Tomography, X-Ray Computed | 2016 |
Donepezil modulates the endogenous immune response: implications for Alzheimer's disease.
Topics: Aged; Aged, 80 and over; alpha7 Nicotinic Acetylcholine Receptor; Alzheimer Disease; Cells, Cultured; Donepezil; Female; GATA3 Transcription Factor; Humans; Immunity, Cellular; Indans; Leukocytes, Mononuclear; Male; Middle Aged; Nootropic Agents; Piperidines | 2016 |
Cholinergic and perfusion brain networks in Parkinson disease dementia.
Topics: Aged; Antiparkinson Agents; Brain; Brain Mapping; Cerebrovascular Circulation; Donepezil; Female; Humans; Indans; Linear Models; Male; Mental Status Schedule; Multivariate Analysis; Neural Pathways; Nootropic Agents; Parkinson Disease; Piperidines; Radiopharmaceuticals; Receptor, Muscarinic M1; Receptor, Muscarinic M4; Receptors, Muscarinic; Tomography, Emission-Computed, Single-Photon | 2016 |
Discrimination performance in aging is vulnerable to interference and dissociable from spatial memory.
Topics: Acetylcholine; Aging; Animals; Cholinesterase Inhibitors; Discrimination, Psychological; Donepezil; Indans; Male; Maze Learning; Piperidines; Rats, Inbred F344; Spatial Memory | 2016 |
Ferulic acid ameliorates memory impairment in d-galactose-induced aging mouse model.
Topics: Acetylcholinesterase; Aging; Animals; Antioxidants; Brain; Caspase 3; Coumaric Acids; Disease Models, Animal; Donepezil; Galactose; Glutathione; Hippocampus; Indans; Interleukin-1beta; Male; Malondialdehyde; Memory Disorders; Mice; NF-kappa B; Nitric Oxide; Oxidative Stress; Piperidines; Superoxide Dismutase | 2016 |
Rosmarinic acid protects against chronic ethanol-induced learning and memory deficits in rats.
Topics: Alcohol-Induced Disorders, Nervous System; Animals; Antioxidants; Avoidance Learning; Behavior, Animal; Biomarkers; Cholinesterase Inhibitors; Cinnamates; Depsides; Dietary Supplements; Donepezil; Exploratory Behavior; Hippocampus; Indans; Learning Disabilities; Lipid Peroxidation; Male; Memory Disorders; Neurons; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Piperidines; Random Allocation; Rats, Wistar; Rosmarinic Acid | 2017 |
Donepezil, an acetylcholinesterase inhibitor, attenuates LPS-induced inflammatory response in murine macrophage cell line RAW 264.7 through inhibition of nuclear factor kappa B translocation.
Topics: Acetylcholinesterase; Active Transport, Cell Nucleus; Animals; Anti-Inflammatory Agents; Cell Nucleus; Cell Survival; Cholinesterase Inhibitors; Cytokines; Donepezil; Gene Expression Regulation; Indans; Inflammation; Lipopolysaccharides; Macrophages; Mice; NF-kappa B; Piperidines; RAW 264.7 Cells | 2016 |
Cholinesterase inhibitors, donepezil and rivastigmine, attenuate spatial memory and cognitive flexibility impairment induced by acute ethanol in the Barnes maze task in rats.
Topics: Animals; Behavior, Animal; Cholinesterase Inhibitors; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Ethanol; Indans; Male; Maze Learning; Memory Disorders; Motor Activity; Nootropic Agents; Piperidines; Rats, Wistar; Reaction Time; Rivastigmine; Rotarod Performance Test; Spatial Memory; Time Factors | 2016 |
Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Electrophorus; Horses; Humans; Indans; Kinetics; Models, Molecular; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; PC12 Cells; Piperidines; Rats; Structure-Activity Relationship | 2016 |
Improved learning of sequential behaviour during cane gait training or stair climbing after femoral neck fracture: an implication for donepezil for very mild Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Canes; Cholinesterase Inhibitors; Donepezil; Executive Function; Female; Femoral Neck Fractures; Gait; Humans; Indans; Learning; Piperidines; Stair Climbing; Treatment Outcome | 2017 |
Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Butyrylcholinesterase; Catalytic Domain; Cell Line, Tumor; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Electrophorus; Horses; Humans; Indans; Indoles; Iron; Kinetics; Melatonin; Molecular Docking Simulation; Peptide Fragments; Piperidines; Protein Multimerization; Rats; Zinc | 2016 |
Reducing falls in Parkinson's disease: interactions between donepezil and the 5-HT
Topics: Animals; Benzylamines; Cholinesterase Inhibitors; Cognition; Cognitive Dysfunction; Corpus Striatum; Donepezil; Dopamine; Female; Gait; Indans; Indoles; Male; Parkinson Disease; Piperidines; Postural Balance; Rats, Sprague-Dawley; Receptors, Serotonin | 2017 |
Effects of Selective M
Topics: Action Potentials; Animals; Benzamides; Biphenyl Compounds; CA1 Region, Hippocampal; CA3 Region, Hippocampal; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Electrodes, Implanted; Exploratory Behavior; Indans; Male; Motor Activity; Periodicity; Piperidines; Pyramidal Cells; Quinolines; Rats, Inbred F344; Receptor, Muscarinic M1; Space Perception; Spatial Memory; Theta Rhythm | 2016 |
Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Copper; Donepezil; Drug Design; Humans; Indans; Kinetics; Liver; Mice; Models, Molecular; Peptide Fragments; Piperidines; Protein Aggregates; Protein Conformation | 2016 |
Microglia-Based Phenotypic Screening Identifies a Novel Inhibitor of Neuroinflammation Effective in Alzheimer's Disease Models.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Discovery; Drug Evaluation, Preclinical; Female; Indans; Male; Memantine; Memory; Mice, Inbred C57BL; Mice, Transgenic; Microglia; Neuroimmunomodulation; Neuroprotective Agents; Peptide Fragments; Phenotype; Piperazines; Piperidines; Pyridazines; Random Allocation; Rats, Sprague-Dawley | 2016 |
Donepezil: It is time to replace physostigmine in Anesthesiology.
Topics: Aging; Anesthesia, General; Anesthesiology; Anesthetics; Brain; Cholinergic Neurons; Cholinesterase Inhibitors; Cognition Disorders; Donepezil; Humans; Indans; Infusions, Intravenous; Learning; Memory; Physostigmine; Piperidines; Postoperative Period; Quality of Life; Time Factors | 2016 |
Molecularly imprinted microparticles in lipid-based formulations for sustained release of donepezil.
Topics: Cholinesterase Inhibitors; Delayed-Action Preparations; Donepezil; Indans; Lipids; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Molecular Imprinting; Piperidines; Spectroscopy, Fourier Transform Infrared | 2016 |
PET Evidence of the Effect of Donepezil on Cognitive Performance in an Animal Model of Chemobrain.
Topics: Animals; Antineoplastic Agents; Brain; Cognition; Cognition Disorders; Disease Models, Animal; Donepezil; Female; Fluorodeoxyglucose F18; Indans; Maze Learning; Memory; Piperidines; Positron-Emission Tomography; Rats, Sprague-Dawley | 2016 |
Fuzhisan ameliorates Aβ production and tau phosphorylation in hippocampal of 11month old APP/PS1 transgenic mice: A Western blot study.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Blotting, Western; Disease Models, Animal; Donepezil; Drugs, Chinese Herbal; Glycogen Synthase Kinase 3; Hippocampus; Indans; Male; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphorylation; Piperidines; Signal Transduction; tau Proteins | 2016 |
The proof-of-concept of ASS234: Peripherally administered ASS234 enters the central nervous system and reduces pathology in a male mouse model of Alzheimer disease.
Topics: Alzheimer Disease; Animals; Cell Survival; Cerebral Cortex; Disease Models, Animal; Donepezil; Gliosis; Hep G2 Cells; Hippocampus; Humans; Indans; Indoles; Learning; Male; Mice, Inbred C57BL; Nootropic Agents; Piperidines; Plaque, Amyloid; Proof of Concept Study; Recognition, Psychology; Scopolamine; Tacrine | 2017 |
The 5-HT
Topics: Alzheimer Disease; Animals; Benzylamines; Brain Stem; Cholinesterase Inhibitors; Donepezil; Electric Stimulation; Electroencephalography; Frontal Lobe; Gamma Rhythm; Indans; Indoles; Male; Piperidines; Rats; Rats, Sprague-Dawley; Receptors, Serotonin; Serotonin Antagonists; Sleep Stages; Wakefulness | 2017 |
α7-nAChR agonist enhances neural plasticity in the hippocampus via a GABAergic circuit.
Topics: Action Potentials; alpha7 Nicotinic Acetylcholine Receptor; Animals; Cholinesterase Inhibitors; Donepezil; Evoked Potentials; Excitatory Amino Acid Antagonists; Female; GABA Agents; GABAergic Neurons; Hippocampus; Humans; Indans; Inhibitory Postsynaptic Potentials; Male; Nerve Net; Nicotinic Agonists; Oocytes; Piperidines; Quinuclidines; Rats; Rats, Sprague-Dawley; Thiophenes; Xenopus laevis | 2016 |
In Vitro Effects of Cognitives and Nootropics on Mitochondrial Respiration and Monoamine Oxidase Activity.
Topics: Alzheimer Disease; Animals; Brain; Cholinesterase Inhibitors; Cognition; Donepezil; Galantamine; Indans; Memantine; Mitochondria; Monoamine Oxidase; Nootropic Agents; Oxygen Consumption; Piperidines; Rivastigmine; Swine | 2017 |
Donepezil promotes differentiation of neural stem cells into mature oligodendrocytes at the expense of astrogenesis.
Topics: Animals; Astrocytes; Cells, Cultured; Donepezil; Glial Fibrillary Acidic Protein; Indans; Myelin Basic Protein; Neural Stem Cells; Neurogenesis; Neurons; Oligodendroglia; Piperidines | 2017 |
Clinical Response to Donepezil in Mild and Moderate Dementia: Relationship to Drug Plasma Concentration and CYP2D6 and APOE Genetic Polymorphisms.
Topics: Apolipoproteins E; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2D6; Dementia; Donepezil; Female; Follow-Up Studies; Humans; Indans; Male; Mental Status and Dementia Tests; Neuropsychological Tests; Piperidines; Polymorphism, Single Nucleotide; Time Factors | 2017 |
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholine; Alzheimer Disease; Cell Line; Donepezil; Drug Delivery Systems; Drug Design; Humans; Indans; Ligands; Microscopy, Electron, Transmission; Molecular Dynamics Simulation; Molecular Structure; Neuroprotective Agents; Piperidines; Protein Aggregation, Pathological; Protein Binding | 2017 |
Synthesis of new donepezil analogues and investigation of their effects on cholinesterase enzymes.
Topics: Acetylcholinesterase; Animals; Butyrylcholinesterase; Chemistry Techniques, Synthetic; Cholinesterase Inhibitors; Donepezil; Drug Design; Electrophorus; Indans; Kinetics; Mice; Molecular Docking Simulation; NIH 3T3 Cells; Piperidines; Protein Conformation; Structure-Activity Relationship | 2016 |
Cholinergic PET imaging in infections and inflammation using
Topics: Acetylcholinesterase; Adult; Aged; Animals; Carbon Radioisotopes; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Cholinesterase Inhibitors; Donepezil; Female; Fluorodeoxyglucose F18; Humans; Indans; Kidney Neoplasms; Lung Neoplasms; Magnetic Resonance Imaging; Male; Mice; Mice, Inbred C57BL; Middle Aged; Piperidines; Positron Emission Tomography Computed Tomography; Radiopharmaceuticals; Staphylococcal Infections; Swine; Vesicular Acetylcholine Transport Proteins | 2017 |
Use of antidementia drugs and risk of pneumonia in older persons with Alzheimer's disease.
Topics: Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Finland; Galantamine; Hospitalization; Humans; Indans; Male; Memantine; Middle Aged; Piperidines; Pneumonia; Risk; Rivastigmine | 2017 |
Rapid and sustained cognitive recovery in APP/PS1 transgenic mice by co-administration of EPPS and donepezil.
Topics: Administration, Oral; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Cognition; Donepezil; Humans; Indans; Mice; Mice, Transgenic; Piperazines; Piperidines; Recovery of Function | 2016 |
Targeting Alzheimer's disease by investigating previously unexplored chemical space surrounding the cholinesterase inhibitor donepezil.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line, Tumor; Cholinesterase Inhibitors; Donepezil; Esters; Humans; Indans; Inhibitory Concentration 50; Molecular Docking Simulation; Molecular Targeted Therapy; Piperidines; Protein Conformation; Structure-Activity Relationship | 2017 |
Protein Expression of BACE1 is Downregulated by Donepezil in Alzheimer's Disease Platelets.
Topics: ADAM10 Protein; Aged; Aged, 80 and over; Alzheimer Disease; Amyloid beta-Protein Precursor; Amyloid Precursor Protein Secretases; Aspartic Acid Endopeptidases; Blood Platelets; Cholinesterase Inhibitors; Donepezil; Down-Regulation; Female; Humans; Indans; Male; Middle Aged; Piperidines; Presenilin-1; Time Factors | 2017 |
Cholinergic activation affects the acute and chronic antinociceptive effects of morphine.
Topics: Acetylcholine; Analgesics, Opioid; Analysis of Variance; Animals; Area Under Curve; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Indans; Male; Mice; Morphine; Pain; Pain Measurement; Piperidines; Rivastigmine; Time Factors | 2017 |
Effects of fisetin on hyperhomocysteinemia-induced experimental endothelial dysfunction and vascular dementia.
Topics: Acetylcholinesterase; Animals; Aorta; Brain; Catalase; Cholesterol; Dementia, Vascular; Donepezil; Dose-Response Relationship, Drug; Endothelium, Vascular; Flavonoids; Flavonols; Glutathione; Homocysteine; Hyperhomocysteinemia; Indans; Lipid Peroxidation; Male; Maze Learning; Methionine; Necrosis; Nitric Oxide; Nitrites; Piperidines; Rats; Superoxide Dismutase | 2017 |
Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment.
Topics: Aged; Aged, 80 and over; Apolipoprotein E4; Butyrylcholinesterase; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Progression; Donepezil; Female; Gene Frequency; Genotype; Humans; Indans; Longitudinal Studies; Male; Mental Status Schedule; Middle Aged; Neuropsychological Tests; Outcome Assessment, Health Care; Pharmacognosy; Piperidines; Polymorphism, Single Nucleotide; Time Factors | 2017 |
Dose-dependent effect of donepezil administration on long-term enhancement of visually evoked potentials and cholinergic receptor overexpression in rat visual cortex.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Evoked Potentials, Visual; Gene Expression; Indans; Piperidines; Rats; Receptors, Cholinergic; Receptors, Nicotinic; Visual Cortex | 2016 |
The effects of fluorine substitution on the chemical properties and inhibitory capacity of Donepezil anti-Alzheimer drug; density functional theory and molecular docking calculations.
Topics: Alzheimer Disease; Donepezil; Electrons; Fluorine; Humans; Hydrogen Bonding; Indans; Models, Molecular; Molecular Docking Simulation; Piperidines; Quantum Theory; Spectroscopy, Fourier Transform Infrared; Spectrum Analysis, Raman; Static Electricity | 2017 |
Cholinesterase inhibitors are compatible with psychosocial intervention for Alzheimer disease patients suggested by neuroimaging findings.
Topics: Aged; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Middle Aged; Neuroimaging; Piperidines; Social Behavior; Tomography, Emission-Computed, Single-Photon | 2017 |
A case of successful treatment with donepezil of olfactory hallucination in parkinson disease.
Topics: Aged; Cerebrovascular Circulation; Donepezil; Female; Hallucinations; Humans; Indans; Iodine Radioisotopes; Iofetamine; Parkinson Disease; Piperidines; Radiopharmaceuticals; Temporal Lobe; Tomography, Emission-Computed, Single-Photon; Treatment Outcome | 2017 |
Using Drugs as Molecular Probes: A Computational Chemical Biology Approach in Neurodegenerative Diseases.
Topics: Alzheimer Disease; Amyotrophic Lateral Sclerosis; Computational Biology; Computer Simulation; Cyclosporine; Donepezil; Drug Repositioning; Humans; Indans; Molecular Probes; Neuroprotective Agents; Piperidines; Riluzole; Structure-Activity Relationship | 2017 |
Combined Memantine and Donepezil Treatment Improves Behavioral and Psychological Symptoms of Dementia-Like Behaviors in Olfactory Bulbectomized Mice.
Topics: Animals; Cholinesterase Inhibitors; Dementia; Donepezil; Drug Therapy, Combination; Excitatory Amino Acid Antagonists; Indans; Male; Maze Learning; Memantine; Mice; Olfactory Bulb; Piperidines; Random Allocation; Treatment Outcome | 2017 |
Advanced Structure-activity Relationships Applied to Mentha spicata L. Subsp. spicata Essential Oil Compounds as AChE and NMDA Ligands, in Comparison with Donepezil, Galantamine and Memantine - New Approach in Brain Disorders Pharmacology.
Topics: Cholinesterase Inhibitors; Cyclohexanols; Donepezil; Eucalyptol; Excitatory Amino Acid Antagonists; Galantamine; Hydrophobic and Hydrophilic Interactions; Indans; Memantine; Mentha spicata; Models, Molecular; Molecular Structure; Monoterpenes; Oils, Volatile; Piperidines; Structure-Activity Relationship | 2017 |
Does caffeine influence the anticholinesterase and antioxidant properties of donepezil? Evidence from in vitro and in vivo studies.
Topics: Acetylcholinesterase; Animals; Antioxidants; Brain Chemistry; Caffeine; Central Nervous System Stimulants; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Food-Drug Interactions; Free Radical Scavengers; In Vitro Techniques; Indans; Iron Chelating Agents; Lipid Peroxidation; Nootropic Agents; Piperidines; Rats | 2017 |
Decreased intestinal acetylcholinesterase in early Parkinson disease: An
Topics: Acetylcholinesterase; Aged; Area Under Curve; Carbon Radioisotopes; Cross-Sectional Studies; Donepezil; Female; Heart; Humans; Indans; Intestines; Kidney; Male; Middle Aged; Myocardium; Pancreas; Parkinson Disease; Piperidines; Positron-Emission Tomography; Radiopharmaceuticals; ROC Curve; Time Factors | 2017 |
Anti-amnestic Effect of Curcumin in Combination with Donepezil, an Anticholinesterase Drug: Involvement of Cholinergic System.
Topics: Adenosine Deaminase; Animals; Brain; Catalase; Cholinergic Neurons; Cholinesterase Inhibitors; Curcumin; Donepezil; Drug Synergism; Glutathione; Indans; Lipid Peroxidation; Male; Maze Learning; Memory Disorders; Nitric Oxide; Piperidines; Rats; Recognition, Psychology; Scopolamine; Superoxide Dismutase | 2017 |
Pisa syndrome due to donepezil: pharmacokinetic interactions to blame?
Topics: Aged, 80 and over; Cholinesterase Inhibitors; Donepezil; Drug Interactions; Dystonic Disorders; Humans; Indans; Male; Omeprazole; Piperidines; Polypharmacy; Postural Balance; Proton Pump Inhibitors; Risk Factors | 2017 |
The Anti-dementia Effects of Donepezil Involve miR-206-3p in the Hippocampus and Cortex.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain-Derived Neurotrophic Factor; Cerebral Cortex; Donepezil; Hippocampus; Humans; Indans; Maze Learning; Memory; Mice; Mice, Transgenic; MicroRNAs; Piperidines; Presenilin-1; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Tolerability of Cholinesterase Inhibitors: A Population-Based Study of Persistence, Adherence, and Switching.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drug Tolerance; Female; Galantamine; Humans; Indans; Male; Medication Adherence; Piperidines; Rivastigmine | 2017 |
Inhibitor of Phosphodiestearse-4 improves memory deficits, oxidative stress, neuroinflammation and neuropathological alterations in mouse models of dementia of Alzheimer's Type.
Topics: Acetylcholinesterase; Aging; Alzheimer Disease; Animals; Antioxidants; Brain; Cholinesterase Inhibitors; Donepezil; Female; Indans; Inflammation; Learning; Male; Maze Learning; Memory Disorders; Mice; Neutrophil Infiltration; Oxidative Stress; Phosphodiesterase 4 Inhibitors; Piperidines; Plaque, Amyloid; Rolipram; Streptozocin | 2017 |
Taste-Masking Effect of Chlorogenic Acid (CGA) on Bitter Drugs Evaluated by Taste Sensor and Surface Plasmon Resonance on the Basis of CGA-Drug Interactions.
Topics: Alanine; Amlodipine; Chlorogenic Acid; Diclofenac; Diphenhydramine; Donepezil; Drug Interactions; Etodolac; Indans; Piperidines; Quinolones; Surface Plasmon Resonance; Taste | 2017 |
Multifunctional Compound AD-35 Improves Cognitive Impairment and Attenuates the Production of TNF-α and IL-1β in an Aβ25-35-induced Rat Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Astrocytes; Brain; Cell Line, Tumor; Cholinesterase Inhibitors; Cognitive Dysfunction; Disease Models, Animal; Donepezil; Humans; Indans; Interleukin-1beta; Male; Memory Disorders; Nootropic Agents; Peptide Fragments; Piperidines; Protein Aggregation, Pathological; Random Allocation; Rats, Sprague-Dawley; Tumor Necrosis Factor-alpha | 2017 |
Inhibitory effects of cholinesterase inhibitor donepezil on the Kv1.5 potassium channel.
Topics: Cholinesterase Inhibitors; Donepezil; HEK293 Cells; Humans; Indans; Ion Channel Gating; Kinetics; Kv1.5 Potassium Channel; Piperidines; Potassium Channel Blockers; Time Factors | 2017 |
Effects of donepezil on sleep disturbances in patients with dementia with Lewy bodies: An open-label study with actigraphy.
Topics: Actigraphy; Aged; Aged, 80 and over; Delusions; Donepezil; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Humans; Indans; Lewy Body Disease; Male; Mental Status Schedule; Motor Activity; Piperidines; Sleep Deprivation; Treatment Outcome | 2017 |
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Topics: Alzheimer Disease; Animals; Brain Ischemia; Calcium Channel Blockers; Cholinesterase Inhibitors; Donepezil; Glutamates; Hippocampus; Humans; Indans; Neuroprotective Agents; Piperidines; Rats; Solid-Phase Synthesis Techniques | 2017 |
Standardized extract of Lactuca sativa Linn. and its fractions abrogates scopolamine-induced amnesia in mice: A possible cholinergic and antioxidant mechanism.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Behavior, Animal; Catalase; Cholinergic Agents; Donepezil; Dose-Response Relationship, Drug; Glutathione; Indans; Lactuca; Male; Malondialdehyde; Maze Learning; Memory; Mice; Nitrites; Piperidines; Plant Extracts; Plant Leaves; Scopolamine; Superoxide Dismutase | 2018 |
Tropisetron sensitizes α7 containing nicotinic receptors to low levels of acetylcholine in vitro and improves memory-related task performance in young and aged animals.
Topics: Acetylcholine; Aging; alpha7 Nicotinic Acetylcholine Receptor; Animals; Donepezil; Dose-Response Relationship, Drug; Female; Humans; Indans; Indoles; Macaca mulatta; Male; Memory; Nicotinic Agonists; Nootropic Agents; Oocytes; Piperidines; Rats, Inbred F344; Rats, Sprague-Dawley; Serotonin Antagonists; Tropisetron; Xenopus laevis | 2017 |
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Topics: Acrylates; Alzheimer Disease; Animals; Anti-Inflammatory Agents; Antioxidants; Cell Line; Cells, Cultured; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Male; Mice; Molecular Docking Simulation; Molecular Targeted Therapy; Neurons; Neuroprotective Agents; Piperidines; Structure-Activity Relationship | 2017 |
Donepezil, an Acetylcholinesterase Inhibitor, Can Attenuate Gabapentinoid-Induced Somnolence in Patients with Neuropathic Pain: A Retrospective Chart Review.
Topics: Adult; Aged; Aged, 80 and over; Amines; Cholinesterase Inhibitors; Cyclohexanecarboxylic Acids; Disorders of Excessive Somnolence; Donepezil; Female; Gabapentin; gamma-Aminobutyric Acid; Humans; Indans; Male; Middle Aged; Neuralgia; Pain Measurement; Piperidines; Pregabalin; Retrospective Studies | 2017 |
Gelidiella acerosa protects against Aβ 25-35-induced toxicity and memory impairment in Swiss Albino mice: an in vivo report.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Amyloid Precursor Protein Secretases; Animals; Apoptosis; bcl-2-Associated X Protein; Behavior, Animal; Brain; Butyrylcholinesterase; Caspase 3; Disease Models, Animal; Donepezil; Escape Reaction; GPI-Linked Proteins; Indans; Lipid Peroxidation; Male; Maze Learning; Memory; Memory Disorders; Mice; Monoamine Oxidase; Neuroprotective Agents; Nootropic Agents; Oxidative Stress; Peptide Fragments; Piperidines; Protein Carbonylation; Seaweed | 2017 |
Different pharmacological responses in late-life depression with subsequent dementia: a case supporting the reserve threshold theory.
Topics: Aged; Antidepressive Agents; Brain; Cholinesterase Inhibitors; Cognitive Reserve; Dementia, Vascular; Depression; Donepezil; Female; Humans; Indans; Magnetic Resonance Imaging; Piperidines; Treatment Outcome | 2017 |
Cholinergic, But Not Dopaminergic or Noradrenergic, Enhancement Sharpens Visual Spatial Perception in Humans.
Topics: Adrenergic alpha-2 Receptor Agonists; Adult; Bromocriptine; Cholinesterase Inhibitors; Contrast Sensitivity; Donepezil; Dopamine Agonists; Female; Guanfacine; Humans; Indans; Male; Piperidines; Random Allocation; Visual Cortex | 2017 |
Clinical meaningfulness of Alzheimer's Disease Assessment Scale-Cognitive subscale change in relation to goal attainment in patients on cholinesterase inhibitors.
Topics: Activities of Daily Living; Aged; Aged, 80 and over; Alzheimer Disease; Canada; Cholinesterase Inhibitors; Clinical Trials as Topic; Cognition Disorders; Donepezil; Double-Blind Method; Female; Galantamine; Goals; Humans; Indans; Male; Multicenter Studies as Topic; Outcome Assessment, Health Care; Piperidines; Severity of Illness Index | 2017 |
Surface modified nano-lipid drug conjugates of positive allosteric modulators of M1 muscarinic acetylcholine receptor for the treatment of Alzheimer's disease.
Topics: Acetylcholine; Allosteric Site; Alzheimer Disease; Animals; Blood-Brain Barrier; Brain; Cholinesterase Inhibitors; Donepezil; Drug Delivery Systems; Gene Expression Regulation; Humans; Indans; Ligands; Lipids; Mice; Models, Theoretical; Nanoconjugates; Nanomedicine; Particle Size; Phosphorylation; Piperidines; Plaque, Amyloid; Receptor, Muscarinic M1; Surface Properties | 2017 |
Simultaneous usage of dementia medications and anticholinergics among Asians and Pacific Islanders.
Topics: Aged; Aged, 80 and over; Asian People; Cholinergic Antagonists; Cholinesterase Inhibitors; Dementia; Donepezil; Female; Galantamine; Hawaii; Hospitals, Urban; Humans; Indans; Male; Memantine; Native Hawaiian or Other Pacific Islander; Pacific Islands; Piperidines; Retrospective Studies; Rivastigmine | 2017 |
Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Blood-Brain Barrier; Cell Survival; Cholinesterase Inhibitors; Donepezil; Drug Design; Electrophorus; Humans; Indans; Mice; Molecular Docking Simulation; Neuroprotective Agents; PC12 Cells; Peptide Fragments; Piperidines; Protein Aggregates; Pyridinium Compounds; Rats; Structure-Activity Relationship | 2017 |
Statistical properties of continuous composite scales and implications for drug development.
Topics: Activities of Daily Living; Alzheimer Disease; Antibodies, Monoclonal, Humanized; Clinical Trials, Phase III as Topic; Donepezil; Drug Discovery; Humans; Indans; Piperidines; Treatment Outcome | 2017 |
All-Solid-State, PVC Membrane, and Carbon Paste Ion-Selective Electrodes for Determination of Donepezil Hydrochloride in Pharmaceutical Formulation.
Topics: Carbon; Donepezil; Hydrogen-Ion Concentration; Indans; Ion-Selective Electrodes; Pharmaceutical Preparations; Piperidines; Polyvinyl Chloride; Potentiometry | 2017 |
The efficacy of donepezil administration on acetylcholinesterase activity and altered redox homeostasis in Alzheimer's disease.
Topics: Acetylcholinesterase; Aged; Alzheimer Disease; Antioxidants; Biomarkers; Case-Control Studies; Cholinesterase Inhibitors; Donepezil; Female; Homeostasis; Humans; Indans; Male; Oxidation-Reduction; Oxidative Stress; Piperidines; Serum Albumin, Human | 2017 |
Inhibitory effect of donepezil on bradykinin-induced increase in the intracellular calcium concentration in cultured cortical astrocytes.
Topics: Acetylcholinesterase; Animals; Astrocytes; Bradykinin; Calcium; Cells, Cultured; Cerebral Cortex; Cholinesterase Inhibitors; Donepezil; Indans; Inflammation; Mecamylamine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperidines; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Reactive Oxygen Species; Thapsigargin | 2017 |
Spatial recognition test: A novel cognition task for assessing topographical memory in mice.
Topics: Alzheimer Disease; Animals; Cognition; Disease Models, Animal; Donepezil; Indans; Levetiracetam; Male; Maze Learning; Memantine; Memory; Memory Disorders; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nootropic Agents; Piperidines; Piracetam; Recognition, Psychology | 2017 |
Coenzyme Q10 and niacin mitigate streptozotocin- induced diabetic encephalopathy in a rat model.
Topics: Animals; Antioxidants; Blood Glucose; Brain Diseases; Cholinesterase Inhibitors; Diabetes Mellitus, Experimental; Donepezil; Glyburide; Hypoglycemic Agents; Indans; Interleukin-6; Male; Neurotransmitter Agents; Niacin; Piperidines; Rats; Rats, Wistar; Ubiquinone; Vitamins | 2017 |
Protective effects of Donepezil against endothelial permeability.
Topics: Donepezil; Dose-Response Relationship, Drug; Endothelium; Human Umbilical Vein Endothelial Cells; Humans; Indans; Matrix Metalloproteinase 9; Permeability; Piperidines; Tissue Inhibitor of Metalloproteinase-1; Tumor Necrosis Factor-alpha | 2017 |
Design and Synthesis of γ- and δ-Lactam M
Topics: Allosteric Regulation; Amphetamine; Animals; Ataxia; Diarrhea; Dogs; Donepezil; Drug Design; Female; Humans; Indans; Isoindoles; Lactams; Male; Mice, Inbred C57BL; Microsomes, Liver; Oxazoles; Piperidines; Rats, Wistar; Receptor, Muscarinic M1; Scopolamine; Seizures; Structure-Activity Relationship; Sulfonamides; Thiadiazoles; Vomiting | 2017 |
Effect of chongmyungtang, a traditional Korean polyherbal formula, on the Pharmacokinetic profiles of donepezil in rats.
Topics: Administration, Oral; Animals; Area Under Curve; Cholinesterase Inhibitors; Donepezil; Half-Life; Herb-Drug Interactions; Indans; Male; Medicine, Korean Traditional; Metabolic Clearance Rate; Phytotherapy; Piperidines; Plant Extracts; Plants, Medicinal; Rats, Sprague-Dawley | 2017 |
Donepezil-Based Central Acetylcholinesterase Inhibitors by Means of a "Bio-Oxidizable" Prodrug Strategy: Design, Synthesis, and in Vitro Biological Evaluation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Animals; Cholinesterase Inhibitors; Donepezil; Drug Design; Female; Humans; Indans; Mice; Molecular Docking Simulation; Piperidines; Prodrugs | 2017 |
Anti-amnesic effects of Ganoderma species: A possible cholinergic and antioxidant mechanism.
Topics: Acetylcholinesterase; Amnesia; Animals; Antioxidants; Avoidance Learning; Behavior, Animal; Biphenyl Compounds; Brain; Cholinesterase Inhibitors; Cognition; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Ganoderma; GPI-Linked Proteins; Indans; Male; Memory; Mice; Nootropic Agents; Picrates; Piperidines; Reaction Time; Recognition, Psychology; Scopolamine; Time Factors | 2017 |
Clinical Pearls in Geriatrics.
Topics: Acetaminophen; Aged; Aged, 80 and over; Automobile Driving; Cognition Disorders; Cognitive Dysfunction; Colonic Neoplasms; Delirium; Dementia; Donepezil; Early Detection of Cancer; Estrogen Replacement Therapy; Female; Geriatrics; Humans; Indans; Male; Neuropsychological Tests; Nootropic Agents; Oxycodone; Piperidines; Urinary Incontinence; Watchful Waiting | 2017 |
Cholinergic symptoms and QTc prolongation following donepezil overdose.
Topics: Aged, 80 and over; Alzheimer Disease; Arrhythmias, Cardiac; Cholinesterase Inhibitors; Donepezil; Drug Overdose; Electrocardiography; Humans; Indans; Male; Piperidines | 2017 |
Sulfasalazine-Induced Crystalluria Causing Severe Acute Kidney Injury.
Topics: Acute Kidney Injury; Aged; Anti-Inflammatory Agents, Non-Steroidal; Antiparkinson Agents; Carbidopa; Cholinesterase Inhibitors; Crohn Disease; Donepezil; Drug Combinations; Fluid Therapy; Humans; Indans; Kidney Calculi; Levodopa; Male; Parkinson Disease; Piperidines; Severity of Illness Index; Sulfasalazine; Ultrasonography | 2017 |
Acetamide Derivatives of Chromen-2-ones as Potent Cholinesterase Inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Blood-Brain Barrier; Butyrylcholinesterase; Cholinesterase Inhibitors; Chromones; Donepezil; Electrophorus; Erythrocytes; Hemolysis; Humans; Indans; Inhibitory Concentration 50; Neuroblastoma; Piperidines | 2017 |
Assessing the binding of cholinesterase inhibitors by docking and molecular dynamics studies.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Hydrogen Bonding; Indans; Molecular Conformation; Molecular Dynamics Simulation; Piperidines; Rivastigmine; Torpedo | 2017 |
Concurrent administration of thyroxine and donepezil induces plastic changes in the prefrontal cortex of adult hypothyroid rats.
Topics: Aging; Animals; Donepezil; Hypothyroidism; Indans; Male; Neuronal Plasticity; Piperidines; Prefrontal Cortex; Rats, Sprague-Dawley; Synaptosomal-Associated Protein 25; Synaptotagmin I; Thyroid Hormones; Thyroxine | 2017 |
Silibinin ameliorates anxiety/depression-like behaviors in amyloid β-treated rats by upregulating BDNF/TrkB pathway and attenuating autophagy in hippocampus.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Anxiety; Autophagy; Brain-Derived Neurotrophic Factor; Depression; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Hippocampus; Indans; Male; Neurons; Neuroprotective Agents; Peptide Fragments; Piperidines; Psychotropic Drugs; Rats, Sprague-Dawley; Receptor, trkB; Signal Transduction; Silybin; Silymarin; Up-Regulation | 2017 |
Utilization of Western medicine and traditional Chinese medicine among patients with Alzheimer's disease in Taiwan: a nationwide population-based study.
Topics: Age Factors; Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Drugs, Chinese Herbal; Female; Humans; Indans; Male; Medicine, Chinese Traditional; Middle Aged; Piperidines; Rivastigmine; Sex Factors; Taiwan; Time-to-Treatment; Urbanization | 2017 |
An advanced technique using an electronic taste-sensing system to evaluate the bitterness of orally disintegrating films and the evaluation of model films.
Topics: Donepezil; Electronic Nose; Indans; Piperidines; Polymers; Quinine; Taste; Technology, Pharmaceutical | 2017 |
Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.
Topics: Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Blood-Brain Barrier; Cell Line; Central Nervous System Agents; Chelating Agents; Cholinesterase Inhibitors; Chromans; Copper; Donepezil; Drug Design; Drug Evaluation, Preclinical; Humans; Indans; Male; Mice, Inbred ICR; Microglia; Molecular Docking Simulation; Monoamine Oxidase Inhibitors; Neurotoxins; Oxidants; PC12 Cells; Peptide Fragments; Piperidines; Protein Aggregation, Pathological; Rats; Structure-Activity Relationship | 2017 |
Long Acting Ionically Paired Embonate Based Nanocrystals of Donepezil for the Treatment of Alzheimer's Disease: a Proof of Concept Study.
Topics: 3T3 Cells; Acetylcholinesterase; Alzheimer Disease; Animals; Cell Survival; Chemistry, Pharmaceutical; Donepezil; Drug Liberation; Female; Humans; Hydrophobic and Hydrophilic Interactions; Indans; Mice; Nanoparticles; Naphthols; Particle Size; Piperidines; Polyethylene Glycols; Proof of Concept Study; Rats, Sprague-Dawley; Solubility; Streptozocin; Surface Properties | 2017 |
Donepezil effects on cholesterol and oxysterol plasma levels of Alzheimer's disease patients.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholesterol; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Male; Oxysterols; Piperidines | 2018 |
Effects of donepezil on liver and kidney functions for the treatment of Alzheimer's disease.
Topics: Aged; Alanine Transaminase; Alzheimer Disease; Aspartate Aminotransferases; Biomarkers; Blood Urea Nitrogen; Cholinesterase Inhibitors; Creatinine; Donepezil; Female; Follow-Up Studies; Humans; Indans; Kidney; Liver; Male; Piperidines; Time Factors | 2017 |
Effects of acute administration of donepezil or memantine on sleep-deprivation-induced spatial memory deficit in young and aged non-human primate grey mouse lemurs (Microcebus murinus).
Topics: Aging; Alzheimer Disease; Animals; Cheirogaleidae; Disease Models, Animal; Donepezil; Indans; Male; Memantine; Memory Disorders; Piperidines; Sleep Deprivation; Spatial Memory | 2017 |
Cholinergic Potentiation of Restoration of Visual Function after Optic Nerve Damage in Rats.
Topics: Animals; Cholinesterase Inhibitors; Donepezil; Evoked Potentials, Visual; Indans; Nerve Crush; Neuronal Plasticity; Optic Nerve Injuries; Piperidines; Rats; Recovery of Function; Vision, Ocular; Visual Cortex | 2017 |
Synthesis, Molecular Modeling, and Evaluation of Novel Sulfonylhydrazones as Acetylcholinesterase Inhibitors for Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Binding Sites; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Hydrazones; Indans; Inhibitory Concentration 50; Models, Molecular; Piperidines; Structure-Activity Relationship | 2017 |
Modulatory effect of caffeic acid on cholinesterases inhibitory properties of donepezil.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Butyrylcholinesterase; Caffeic Acids; Cholinesterase Inhibitors; Donepezil; Drug Synergism; Drug Therapy, Combination; Humans; Indans; Male; Nootropic Agents; Piperidines; Rats; Rats, Wistar | 2017 |
Change in Odor Identification Impairment is Associated with Improvement with Cholinesterase Inhibitor Treatment in Mild Cognitive Impairment.
Topics: Aged; Atropine; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Female; Humans; Indans; Male; Memory; Muscarinic Antagonists; Neuropsychological Tests; Odorants; Olfaction Disorders; Olfactory Perception; Pattern Recognition, Physiological; Piperidines; Prognosis; Psychotropic Drugs; Treatment Outcome | 2017 |
Diverse Effects of an Acetylcholinesterase Inhibitor, Donepezil, on Hippocampal Neuronal Death after Pilocarpine-Induced Seizure.
Topics: Animals; Cell Death; Cholinesterase Inhibitors; Disease Models, Animal; Donepezil; Drug Administration Schedule; Epilepsy, Temporal Lobe; Hippocampus; Indans; Male; Neurons; Nootropic Agents; Oxidative Stress; Pilocarpine; Piperidines; Rats, Sprague-Dawley; Seizures | 2017 |
Simultaneous monitoring of electroencephalographic characteristics in animals subjected to behavioral tests: a preclinical investigation.
Topics: Amphetamine; Animals; Brain; Central Nervous System Agents; Donepezil; Electrocorticography; Electrodes, Implanted; Exploratory Behavior; Indans; Male; Motor Activity; Neuropsychological Tests; Piperidines; Rats, Wistar; Recognition, Psychology; Scopolamine; Telemetry | 2017 |
Involvement of glucose related energy crisis and endoplasmic reticulum stress: Insinuation of streptozotocin induced Alzheimer's like pathology.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid; Animals; Biomarkers; Caspase 12; Cerebral Cortex; Connexin 43; Disease Models, Animal; Donepezil; Endoplasmic Reticulum Stress; Gene Expression Regulation; Glucose; Glucose Transport Proteins, Facilitative; GPI-Linked Proteins; Heat-Shock Proteins; Hippocampus; Indans; Injections, Intraventricular; Male; Neurons; Nootropic Agents; Piperidines; Rats; Rats, Sprague-Dawley; Stereotaxic Techniques; Streptozocin; tau Proteins | 2018 |
A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Avoidance Learning; Behavior, Animal; Benzothiazoles; Cholinesterase Inhibitors; Cognition Disorders; Disease Models, Animal; Donepezil; Dose-Response Relationship, Drug; Indans; Locomotion; Maze Learning; Molecular Docking Simulation; Piperazines; Piperidines; Rats; Rats, Wistar; Streptozocin | 2017 |
A chiral enantioseparation generic strategy for anti-Alzheimer and antifungal drugs by short end injection capillary electrophoresis using an experimental design approach.
Topics: Alzheimer Disease; Antifungal Agents; Cyclodextrins; Donepezil; Electrophoresis, Capillary; Indans; Injections; Piperidines; Rivastigmine; Stereoisomerism | 2018 |
Neither Cholinergic Nor Dopaminergic Enhancement Improve Spatial Working Memory Precision in Humans.
Topics: Acetylcholine; Adolescent; Adult; Carbidopa; Donepezil; Dopamine; Double-Blind Method; Drug Combinations; Female; Humans; Indans; Levodopa; Male; Memory, Short-Term; Neuropsychological Tests; Nootropic Agents; Piperidines; Psychometrics; Spatial Memory; Treatment Failure; Visual Perception; Young Adult | 2017 |
Nicotinic alpha 7 receptor agonists EVP-6124 and BMS-933043, attenuate scopolamine-induced deficits in visuo-spatial paired associates learning.
Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Donepezil; Indans; Macaca fascicularis; Male; Paired-Associate Learning; Piperidines; Quinuclidines; Reaction Time; Scopolamine; Space Perception; Spiro Compounds; Task Performance and Analysis; Thiophenes; Treatment Outcome; Visual Perception | 2017 |
Similar treatment outcomes with Ginkgo biloba extract EGb 761 and donepezil in Alzheimer's dementia in very old age: A retrospective observational study.
Topics: Aged, 80 and over; Alzheimer Disease; Cognition; Donepezil; Female; Ginkgo biloba; Humans; Indans; Male; Mental Status and Dementia Tests; Nootropic Agents; Piperidines; Plant Extracts; Retrospective Studies; Treatment Outcome | 2018 |
Amalaki Rasayana improved memory and neuronal metabolic activity in AbPP-PS1 mouse model of Alzheimer's disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Carbon Isotopes; Cognition; Donepezil; gamma-Aminobutyric Acid; Gene Expression; Glucose; Glutamic Acid; Glutamine; Humans; Indans; Male; Maze Learning; Medicine, Ayurvedic; Memory; Mice; Mice, Transgenic; Neurons; Neuroprotective Agents; Piperidines; Plant Extracts; Presenilin-1 | 2017 |
Acetyl Cholinesterase Inhibitors and Cell-Derived Peripheral Inflammatory Cytokines in Early Stages of Alzheimer's Disease.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cytokines; Donepezil; Female; Follow-Up Studies; Humans; Indans; Inflammation; Male; Middle Aged; Piperidines | 2018 |
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Topics: Acetylcholinesterase; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Drug Discovery; Hep G2 Cells; Humans; Hydrazones; Indans; Models, Molecular; Molecular Structure; Neuroprotective Agents; Piperidines; Structure-Activity Relationship | 2018 |
Simple determination of some antidementia drugs in wastewater and human plasma samples by tandem dispersive liquid-liquid microextraction followed by high-performance liquid chromatography.
Topics: Algorithms; Calibration; Cholinesterase Inhibitors; Chromatography, High Pressure Liquid; Donepezil; Humans; Hydrogen-Ion Concentration; Indans; Limit of Detection; Linear Models; Liquid Phase Microextraction; Neuroprotective Agents; Piperidines; Plasma; Reproducibility of Results; Rivastigmine; Salts; Solvents; Wastewater | 2018 |
Systemic administration of donepezil attenuates the efficacy of environmental enrichment on neurobehavioral outcome after experimental traumatic brain injury.
Topics: Analysis of Variance; Animals; Brain Injuries, Traumatic; Cerebral Cortex; Cognition Disorders; Disease Models, Animal; Donepezil; Environment; Indans; Male; Maze Learning; Mental Disorders; Motor Activity; Neurologic Examination; Nootropic Agents; Piperidines; Psychomotor Performance; Rats; Rats, Sprague-Dawley; Rotarod Performance Test; Time Factors | 2018 |
Characteristic deterioration of ADAS-Jcog subscale scores and correlations with regional cerebral blood flow reductions in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Brain; Cerebrovascular Circulation; Cognition; Cysteine; Disease Progression; Donepezil; Female; Humans; Indans; Language; Male; Memory; Mental Status and Dementia Tests; Middle Aged; Nootropic Agents; Organotechnetium Compounds; Piperidines; Radiopharmaceuticals; Tomography, Emission-Computed, Single-Photon | 2018 |
Synthesis and biological evaluation of potential acetylcholinesterase inhibitors based on a benzoxazine core.
Topics: Acetylcholinesterase; Alzheimer Disease; Benzoxazines; Cholinesterase Inhibitors; Donepezil; Drug Design; Humans; Indans; Molecular Docking Simulation; Piperazines; Piperidines; Protein Binding; Structure-Activity Relationship | 2018 |
New therapeutic approaches and novel alternatives for organophosphate toxicity.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Cholinesterase Inhibitors; Cholinesterase Reactivators; Donepezil; High-Throughput Screening Assays; Humans; Hydrolysis; Imidazoles; Indans; Kinetics; Organophosphate Poisoning; Oximes; Piperazines; Piperidines; Pyridines; Structure-Activity Relationship | 2018 |
Chemometrics-assisted spectrophotometric green method for correcting interferences in biowaiver studies: Application to assay and dissolution profiling study of donepezil hydrochloride tablets.
Topics: Biological Assay; Chemistry, Pharmaceutical; Cholinesterase Inhibitors; Donepezil; Dosage Forms; Drug Liberation; Humans; Indans; Piperidines; Solubility; Spectrophotometry, Ultraviolet; Tablets | 2018 |
Combination of human acetylcholinesterase and serum albumin sensing surfaces as highly informative analytical tool for inhibitor screening.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Edrophonium; Enzymes, Immobilized; Galantamine; Humans; Indans; Kinetics; Ligands; Piperidines; Recombinant Fusion Proteins; Serum Albumin; Surface Plasmon Resonance; Tacrine | 2018 |
Kinetic and structural studies on the interactions of Torpedo californica acetylcholinesterase with two donepezil-like rigid analogues.
Topics: Acetylcholinesterase; Animals; Cholinesterase Inhibitors; Crystallography, X-Ray; Donepezil; Dose-Response Relationship, Drug; Indans; Kinetics; Molecular Docking Simulation; Molecular Structure; Piperidines; Structure-Activity Relationship; Torpedo | 2018 |
Protective effect of betulinic acid against intracerebroventricular streptozotocin induced cognitive impairment and neuronal damage in rats: Possible neurotransmitters and neuroinflammatory mechanism.
Topics: Acetylcholinesterase; Animals; Betulinic Acid; Cognitive Dysfunction; Disease Models, Animal; Donepezil; Glutathione; Hippocampus; Indans; Inflammation; Injections, Intraventricular; Male; Maze Learning; Memory; Memory Disorders; Neuroprotective Agents; Neurotransmitter Agents; Oxidative Stress; Pentacyclic Triterpenes; Piperidines; Rats; Rats, Wistar; Streptozocin; Triterpenes | 2018 |
Safety and Efficacy of Anti-dementia Agents in the Extremely Elderly Patients with Dementia.
Topics: Activities of Daily Living; Aged, 80 and over; Alzheimer Disease; Donepezil; Exanthema; Female; Humans; Indans; Male; Medication Adherence; Nausea; Neuropsychological Tests; Nootropic Agents; Piperidines; Retrospective Studies; Rivastigmine; Treatment Outcome | 2018 |
Protective Effects of Donepezil Against Alcohol-Induced Toxicity in Cell Culture: Role of Caspase-3.
Topics: Caspase 3; Cell Line, Tumor; Central Nervous System Depressants; Donepezil; Dose-Response Relationship, Drug; Drug Synergism; Ethanol; Humans; Indans; Neuroblastoma; Neuroprotective Agents; Piperidines | 2018 |
Stepwise occlusion of the carotid arteries of the rat: MRI assessment of the effect of donepezil and hypoperfusion-induced brain atrophy and white matter microstructural changes.
Topics: Animals; Brain Ischemia; Carotid Artery, Common; Carotid Stenosis; Cerebrovascular Circulation; Diffusion Tensor Imaging; Donepezil; Indans; Male; Oxygen; Piperidines; Rats; Rats, Wistar; White Matter | 2018 |
1-Benzyl-4-methylpiperidinyl moiety in donepezil: The priority ticket across the blood-brain-barrier in rats.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Chromatography, High Pressure Liquid; Donepezil; Indans; Linear Models; Male; Piperidines; Rats; Rats, Wistar; Reproducibility of Results; Sensitivity and Specificity | 2018 |
Possible mechanism of Vitis vinifera L. flavones on neurotransmitters, synaptic transmission and related learning and memory in Alzheimer model rats.
Topics: Acetylcholine; Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Brain-Derived Neurotrophic Factor; Choline O-Acetyltransferase; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Disease Models, Animal; Donepezil; Flavones; Gene Expression Regulation; Hippocampus; Indans; Male; Maze Learning; Memory; Neurotransmitter Agents; Nootropic Agents; Peptide Fragments; Piperidines; Protein Aggregates; Rats; Rats, Sprague-Dawley; Synaptic Transmission; Synaptotagmin I; Vitis | 2018 |
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cell Line; Cholinesterase Inhibitors; Donepezil; Enzyme Inhibitors; Flavonoids; Humans; Indans; Lipoxygenase Inhibitors; Male; Mice, Inbred BALB C; Models, Molecular; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Neurogenesis; Neuroprotective Agents; Piperidines; Receptors, sigma; Sigma-1 Receptor | 2018 |
Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Animals; Antioxidants; Butylated Hydroxytoluene; Cell Line; Cholinergic Agents; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Indans; Mice; Molecular Structure; Neuroprotective Agents; PC12 Cells; Piperidines; Protein Aggregates; Rats; Structure-Activity Relationship | 2018 |
Quinoline containing chalcone derivatives as cholinesterase inhibitors and their in silico modeling studies.
Topics: Acetylcholinesterase; Butyrylcholinesterase; Chalcones; Cholinesterase Inhibitors; Donepezil; Enzyme Assays; Humans; Indans; Kinetics; Ligands; Molecular Docking Simulation; Neostigmine; Piperidines; Protein Binding; Quinolines; Structure-Activity Relationship | 2018 |
Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer's drug candidates.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Caco-2 Cells; Cell Line, Tumor; Cell Survival; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Humans; Indans; Models, Molecular; Molecular Structure; Piperidines; Protein Aggregates; Structure-Activity Relationship | 2018 |
The histamine H3R antagonist DL77 attenuates autistic behaviors in a prenatal valproic acid-induced mouse model of autism.
Topics: Animals; Anxiety; Autistic Disorder; Behavior, Animal; Brain; Choice Behavior; Cytokines; Disease Models, Animal; Donepezil; Exploratory Behavior; Female; Histamine H3 Antagonists; Inflammation Mediators; Malondialdehyde; Maze Learning; Mice; Motor Activity; Oxidative Stress; Phenyl Ethers; Piperidines; Receptors, Histamine H3; Social Behavior; Stereotyped Behavior; Valproic Acid | 2018 |
Aging-related Repositioned Drugs, Donepezil and Sildenafil Citrate, Increase Apoptosis of Anti-mitotic Drug-resistant KBV20C Cells Through Different Molecular Mechanisms.
Topics: Antimitotic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Squamous Cell; Cell Line, Tumor; Cell Survival; Donepezil; Down-Regulation; Drug Repositioning; Drug Resistance, Neoplasm; Drug Synergism; Furans; Gene Expression Regulation, Neoplastic; Humans; Indans; Ketones; Mouth Neoplasms; Piperidines; Sildenafil Citrate; Vincristine | 2018 |
Metformin and its sulphonamide derivative simultaneously potentiateanti-cholinesterase activity of donepezil and inhibit beta-amyloid aggregation.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Butyrylcholinesterase; Cholinesterase Inhibitors; Donepezil; Dose-Response Relationship, Drug; Healthy Volunteers; Humans; Indans; Inhibitory Concentration 50; Kinetics; Metformin; Molecular Structure; Piperidines; Protein Binding; Structure-Activity Relationship; Sulfonamides | 2018 |
In silico, NMR and pharmacological evaluation of an hydroxyoxindole cholinesterase inhibitor.
Topics: Acetylcholinesterase; Animals; Artemia; Brain; Butyrylcholinesterase; Catalytic Domain; Cholinesterase Inhibitors; Donepezil; Electrophorus; Humans; Indoles; Liver; Magnetic Resonance Spectroscopy; Male; Mice; Molecular Docking Simulation; Piperidines; Protein Binding; Stereoisomerism | 2019 |
Trends of antidementia drugs use in outpatients with Alzheimer's disease in six major cities of China: 2012-2017.
Topics: Aged; Alzheimer Disease; China; Cholinesterase Inhibitors; Donepezil; Female; Humans; Male; Memantine; Nootropic Agents; Piperidines | 2019 |
Simultaneous determination of donepezil, 6-O-desmethyl donepezil and spinosin in beagle dog plasma using liquid chromatography‒tandem mass spectrometry and its application to a drug-drug interaction study.
Topics: Animals; Chromatography, High Pressure Liquid; Dogs; Donepezil; Drug Interactions; Flavonoids; Indans; Male; Piperidines; Plasma; Reproducibility of Results; Republic of Korea; Seeds; Tandem Mass Spectrometry; Ziziphus | 2020 |
Design, Synthesis, and In Vitro Evaluation of Hydroxybenzimidazole-Donepezil Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Antioxidants; Chelating Agents; Cholinesterase Inhibitors; Donepezil; Humans; Indazoles; Ligands; Molecular Docking Simulation; Molecular Structure; Piperazine; Piperidines; Structure-Activity Relationship | 2020 |
Are cytochrome P4502D6 and apolipoprotein E genotypes associated with long-term cognitive and functional changes in patients treated with donepezil?
Topics: Activities of Daily Living; Alzheimer Disease; Apolipoprotein E4; Apolipoproteins E; Cognition; Cytochrome P-450 CYP2D6; Donepezil; Genotype; Humans; Indans; Nootropic Agents; Piperidines | 2020 |
Multiple target-based combination therapy of galantamine, memantine and lycopene for the possible treatment of Alzheimer's disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Lycopene; Memantine; Piperidines | 2020 |
[Practical aspects of using donepezil in the treatment of dementia].
Topics: Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Russia | 2020 |
Donepezil induces ventricular arrhythmias by delayed repolarisation.
Topics: Alzheimer Disease; Animals; Arrhythmias, Cardiac; Atrioventricular Block; Cholinesterase Inhibitors; Dogs; Donepezil; Halothane; Indans; Piperidines | 2021 |
The functional effects of piperine and piperine plus donepezil on hippocampal synaptic plasticity impairment in rat model of Alzheimer's disease.
Topics: Alkaloids; Alzheimer Disease; Animals; Avoidance Learning; Benzodioxoles; Cytochrome P-450 Enzyme Inhibitors; Disease Models, Animal; Donepezil; Drug Therapy, Combination; Hippocampus; Male; Neuronal Plasticity; Nootropic Agents; Piperidines; Polyunsaturated Alkamides; Rats; Rats, Wistar; Streptozocin; Treatment Outcome | 2021 |
Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Potential Treatment of Alzheimer's Disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Amyloid beta-Peptides; Cell Line, Tumor; Cholinesterase Inhibitors; Donepezil; Humans; Ligands; Piperazines; Piperidines; Structure-Activity Relationship; Sulfonamides | 2021 |
The Impact of Dextran Sodium Sulfate-Induced Gastrointestinal Injury on the Pharmacokinetic Parameters of Donepezil and Its Active Metabolite 6-
Topics: Animals; Capsule Endoscopy; Dextran Sulfate; Donepezil; Female; Gastrointestinal Tract; Indans; Metabolome; Myoelectric Complex, Migrating; Piperidines; Stomach; Swine | 2021 |
Donepezil overdose secondary to use of a smart home device for medication reminders.
Topics: Cholinesterase Inhibitors; Donepezil; Drug Overdose; Humans; Medication Adherence; Piperidines | 2022 |
Analysis of treatment pattern of anti-dementia medications in newly diagnosed Alzheimer's dementia using OMOP CDM.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Galantamine; Humans; Indans; Memantine; Phenylcarbamates; Piperidines; Rivastigmine | 2022 |
Risk of Serious Adverse Events Associated With Individual Cholinesterase Inhibitors Use in Older Adults With Dementia: A Population-Based Cohort Study.
Topics: Aged; Alzheimer Disease; Cholinesterase Inhibitors; Cohort Studies; Donepezil; Female; Galantamine; Humans; Indans; Male; Medicare; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine; United States | 2022 |
Combination of NSAIDs with donepezil as multi-target directed ligands for the treatment of Alzheimer's disease.
Topics: Acetylcholinesterase; Alzheimer Disease; Anti-Inflammatory Agents, Non-Steroidal; Cholinesterase Inhibitors; Cyclooxygenase 2; Donepezil; Humans; Ligands; Lipopolysaccharides; Molecular Docking Simulation; Piperidines; Structure-Activity Relationship; Tumor Necrosis Factor-alpha | 2022 |
Pharmaco-fUS in cognitive impairment: Lessons from a preclinical model.
Topics: Acetylcholinesterase; Alzheimer Disease; Animals; Cognitive Dysfunction; Donepezil; Humans; Indans; Mice; Piperidines; RNA-Binding Protein FUS; Scopolamine | 2022 |
Anti-Dementia Drug Persistence Following Donepezil Initiation Among Alzheimer's Disease Patients in Japan: LIFE Study.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Japan; Piperidines | 2022 |
Combination of Donepezil and Memantine Attenuated Cognitive Impairment Induced by Mixed Endocrine-Disrupting Chemicals: an In Silico Study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognitive Dysfunction; Donepezil; Humans; Indans; Memantine; MicroRNAs; Piperidines | 2022 |
Real-world effects of anti-dementia treatment on mortality in patients with Alzheimer´s dementia.
Topics: Alzheimer Disease; Donepezil; Female; Galantamine; Humans; Indans; Male; Phenylcarbamates; Piperidines; Retrospective Studies; Rivastigmine | 2022 |
[Abnormal posture of the trunk related to donepezil hydrochloride: report of 2 cases].
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Female; Humans; Indans; Levodopa; Male; Movement Disorders; Piperidines; Posture | 2023 |
Adverse Drug Event Profile Associated with Anti-dementia Drugs: Analysis of a Spontaneous Reporting Database.
Topics: Acetylcholinesterase; Cholinesterase Inhibitors; Donepezil; Drug-Related Side Effects and Adverse Reactions; Galantamine; Humans; Indans; Memantine; Piperidines; Rivastigmine | 2023 |
Design, Synthesis, Molecular Docking, and Molecular Dynamics Simulation Studies of Novel 3-Hydroxypyridine-4-one Derivatives as Potential Acetylcholinesterase Inhibitors.
Topics: Acetylcholinesterase; Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Molecular Docking Simulation; Molecular Dynamics Simulation; Piperidines; Pyridines; Structure-Activity Relationship | 2023 |
Efficacy of donepezil plus hydrogen-oxygen mixture inhalation for treatment of patients with Alzheimer disease: A retrospective study.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Cognition; Donepezil; Humans; Indans; Piperidines; Retrospective Studies; Treatment Outcome | 2023 |
Prevalence of treated patients with Alzheimer's disease: current trends and COVID-19 impact.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; COVID-19; Donepezil; Female; Galantamine; Humans; Indans; Male; Memantine; Pandemics; Phenylcarbamates; Piperidines; Prevalence; Retrospective Studies; Rivastigmine | 2023 |
Long-Term Safety, Tolerability, and Efficacy of a Transdermal Donepezil Patch in Patients with Severe Alzheimer's Disease.
Topics: Alzheimer Disease; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Piperidines; Tablets; Treatment Outcome | 2023 |
Follow-up of Clinical Symptoms and Blood Concentration in Donepezil Overdose.
Topics: Cholinesterase Inhibitors; Donepezil; Drug Overdose; Follow-Up Studies; Humans; Piperidines | 2023 |
Patterns of use of symptomatic treatments for Alzheimer's disease dementia (AD).
Topics: Alzheimer Disease; Donepezil; Humans; Indans; Piperidines; Quality of Life | 2023 |
Consumption of drugs for Alzheimer's disease on the Brazilian private market.
Topics: Alzheimer Disease; Brazil; Cholinesterase Inhibitors; Donepezil; Humans; Indans; Memantine; Phenylcarbamates; Piperidines | 2023 |